Publication Information

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1250, 1261, 1274, 1499, 2179, 2188, 2199, 2231, 2246, 2252, 2310, 2323, 2344, 2378, 2537, 2657, 2732, 2817, 2987, 3146, 3165, 3268, 3493, 3524, 3653, 3697, 3788, 3814, 3904, 3944, 4004, 4019, 4148, 4182, 4964, 4976, 4988, 5009, 5032, 5079, 5112, 5294, 5640, 5674, 5728, 5734, 5772, 5801, 5834], 'are': [29, 41, 192, 204, 517, 724, 1291, 2258, 2368, 2624, 2631, 2805, 2919, 3148, 3207, 3393, 3499, 3602, 3785, 4328, 4425, 4578, 4584, 4606, 5153, 5186, 5194, 5216, 5269, 5364, 5556, 5599, 5645], 'two': [30, 193, 1020], 'proteins': [33, 196, 723, 1052, 2998, 3085, 3095, 3313, 3399, 3704, 3766, 3775, 4279, 4545, 4618, 4652, 4746, 5255, 5268, 5417, 5607], 'associated': [34, 197, 2667, 3384, 3786, 5766], 'with': [35, 98, 124, 198, 261, 287, 562, 921, 1646, 1661, 1738, 1746, 1772, 1832, 1838, 1852, 1859, 1870, 1894, 1902, 1918, 1921, 1977, 1996, 2006, 2025, 2030, 2035, 2051, 2058, 2070, 2094, 2108, 2132, 2140, 2176, 2314, 2360, 2374, 2456, 2541, 2638, 2668, 2677, 2819, 2880, 2884, 2893, 2909, 2932, 2942, 2960, 3167, 3252, 3259, 3283, 3385, 3477, 3652, 3702, 3779, 3787, 3882, 3903, 4143, 4181, 4218, 4315, 4386, 4399, 4586, 4621, 5137, 5168, 5222, 5443, 5726, 5730, 5767], 'inherited': [36, 199, 727, 5752], 'forms': [37, 200, 728, 2621, 4289, 5757], 'PD': [39, 202, 439, 577, 730, 924, 1344, 3608, 3842, 4668, 4726, 5279, 5703, 5753, 5764], 'found': [42, 205, 2536, 2964, 3603, 3647, 3837, 4009, 4119, 5093], 'Whereas': [46, 209, 4198], 'numerous': [47, 210], 'reports': [48, 211, 2376, 3660], 'indicate': [49, 212, 3518], 'tendency': [51, 145, 214, 308, 1233, 4991], 'α-synuclein': [53, 216, 866, 1235, 1483, 3849, 4002, 4027, 4083, 4199, 4255, 4371, 5213, 5335, 5444, 5536, 5567], 'to': [54, 85, 108, 139, 149, 217, 248, 271, 302, 312, 510, 726, 1012, 1046, 1236, 1251, 1270, 1293, 1324, 1348, 1427, 1518, 1527, 1538, 1572, 1626, 2164, 2237, 2260, 2264, 2285, 2291, 2430, 2538, 2701, 2730, 2734, 2786, 2991, 3097, 3152, 3453, 3729, 3732, 3822, 3895, 3997, 4295, 4414, 4654, 4970, 4992, 5013, 5110, 5142, 5272, 5285, 5297, 5332, 5339, 5342, 5367, 5478, 5526, 5633, 5647, 5785, 5804, 5822, 5826, 5840], 'aggregate': [55, 150, 218, 313, 1237, 2659, 4993, 5805], 'bothin': [56, 219], 'vitro': [57, 220], 'vivo,': [60, 223], 'no': [61, 224, 1242, 2965, 3284], 'information': [62, 225, 1243], 'available': [64, 227, 1245], 'about': [65, 228, 506, 1246, 2685, 4598], 'similar': [66, 229, 1292, 1347, 2768, 3149, 3821, 4294, 4413, 5338, 5525], 'physical': [67, 230, 3212], 'properties': [68, 231, 2157], 'for': [69, 157, 232, 320, 1633, 1678, 1691, 1803, 1817, 1828, 1844, 1864, 1882, 1890, 1910, 1981, 2001, 2044, 2061, 2083, 2102, 2125, 2682, 2895, 3175, 3302, 3366, 3724, 3768, 4026, 4189, 5068, 5118], 'Parkin.': [70, 233, 2981, 4390], 'Here': [71, 234, 5650], 'we': [72, 235, 1256, 1332, 2626, 3634, 3646, 4380, 4985, 5651], 'show': [73, 236, 1257, 5652], 'that': [74, 129, 140, 237, 292, 303, 1258, 1334, 2303, 2334, 2364, 2643, 2656, 2663, 2699, 2724, 2778, 2802, 2902, 2916, 2969, 3204, 3296, 3519, 3691, 3773, 4195, 4222, 4403, 4422, 4588, 4605, 4689, 4987, 5005, 5050, 5063, 5088, 5250, 5287, 5346, 5638, 5653, 5672, 5717, 5733, 5741, 5800], 'overexpression': [75, 238, 864, 1259, 2979], 'proteasome': [82, 116, 245, 279, 522, 1267, 1322, 1355, 1470, 1812, 2316, 2679, 3089, 3253, 3479, 3533, 3554, 3600, 3642, 3693, 3898, 4590, 5138, 5204, 5423], 'inhibitors': [83, 246, 1655, 1717, 2741, 5139], 'leads': [84, 247, 1269, 3096], 'formation': [87, 135, 250, 298, 873, 1305, 1336, 1350, 2239, 2294, 2420, 2612, 2766, 2780, 2971, 3135, 3304, 5070, 5127, 5261, 5289, 5299, 5664, 5720], 'aggresome-like': [89, 142, 252, 305, 1352, 5301], 'perinuclear': [90, 253], 'inclusions.': [91, 254, 2871, 5211, 5265, 5354, 5669, 5723], 'These': [92, 255, 1289, 1510, 2653, 3293, 3800, 3993, 4592, 4999, 5266, 5281], 'eosinophilic': [93, 256, 1279, 4426], 'share': [95, 258, 5412], 'many': [96, 259, 4374, 5393], 'characteristics': [97, 260, 3528], 'bodies,': [100, 263, 4416], 'including': [101, 264, 3389, 4753, 5418], 'a': [102, 265, 334, 949, 1048, 1266, 1284, 1287, 1642, 1651, 1665, 1703, 1713, 1931, 1936, 2062, 2150, 2181, 2241, 2691, 2885, 3110, 3173, 3210, 3270, 3458, 3478, 3486, 3811, 3912, 4219, 4292, 4377, 4433, 4547, 4664, 4694, 4978, 4990, 5658, 5715], 'core': [103, 266, 1285, 4230, 5431, 5452], 'halo': [105, 268, 3460, 3907, 5433], 'organization,': [106, 269], 'immunoreactivity': [107, 270, 2818, 2911, 2924, 3490, 3815, 4007, 4176], 'ubiquitin,': [109, 272, 4756, 5003, 5422], 'α-synuclein,': [110, 273, 629, 1057, 1693, 4754, 5420], 'synphilin-1,': [111, 274, 4758, 5421], 'Parkin,': [112, 275, 630, 913, 1531, 2159, 2425, 4755, 5419], 'molecular': [113, 276, 364, 411, 500, 2156, 2183, 3103, 5038], 'chaperones,': [114, 277, 1320, 5202], 'subunit': [117, 280], 'well': [119, 282, 2196], 'staining': [121, 284, 2018, 2107, 2947, 3169, 3824, 3884, 4025, 4187, 4420], 'some': [123, 286, 2603, 3386, 3939, 4325, 5472, 5553], 'thioflavin': [125, 288, 1989, 1998, 4320, 4329, 4387, 4400, 5557], 'S.': [126, 289, 581, 583, 610, 652, 754, 788, 806, 814, 843, 928, 936, 959, 963, 965, 999, 1101, 1176, 2397, 2477, 2485, 2487, 2505, 2511, 2513, 2548, 3000, 3051, 3057, 3076, 3360, 3564, 3750, 3933, 4061, 4087, 4126, 4130, 4237, 4241, 4454, 4505, 4511, 4530, 4821, 4886, 4890, 5456, 5460], 'We': [127, 290, 2340, 2534, 2860, 2953, 3866, 4173], 'propose': [128, 291], 'process': [131, 294, 2665, 2726, 5007], 'body': [134, 297, 5360], 'may': [136, 154, 299, 317, 5064, 5560], 'be': [137, 300, 2346, 2539, 3730, 3777, 5045, 5052, 5273, 5479, 5634, 5648, 5781, 5827], 'akin': [138, 301], 'structures.': [143, 306], 'The': [144, 307, 326, 1359, 1562, 1681, 1696, 2607, 2982, 3221, 3532, 4252, 4430, 4645, 4686, 4961, 5147, 5355, 5636, 5796], 'wild-type': [147, 310, 4648, 5727], 'form': [152, 315, 2265, 4537], 'have': [155, 318, 1230, 3556, 4406, 4555, 5400, 5475, 5529, 5847], 'implications': [156, 319], 'pathogenesis': [159, 322, 4600, 5748], 'sporadic': [161, 324, 5756], 'PD.': [162, 325, 5851], 'accumulation': [327, 463, 1272, 3099, 3266, 4540, 4646, 5787], 'insoluble': [329, 1684, 4283], 'intracellular': [330, 875, 2419, 3381, 4436, 4613, 4651], 'protein': [331, 568, 876, 1008, 2168, 4085, 4574, 4691, 4765, 5349, 5656, 5743], 'aggregates': [332, 877, 1275, 2630, 2949, 3108, 3147, 3166, 4020, 4290, 5000, 5023, 5336], 'hallmark': [335], '1The': [340, 387], 'abbreviations': [341, 388], 'used': [342, 389, 1363, 1687, 2163], 'are:': [343, 390], 'PD,': [344, 391], 'disease;': [346, 393], 'TRITC,': [347, 394], 'tetramethylrhodamine': [348, 395], 'isothiocyanate;': [349, 396], 'HA,': [350, 397], 'hemagglutinin;': [351, 398], 'PBS,': [352, 399, 1919], 'phosphate-buffered': [353, 400], 'saline;': [354, 401], 'BSA,': [355, 402], 'bovine': [356, 403, 1595, 1613], 'serum': [357, 404, 1609], 'albumin;': [358, 405], 'DAPI,': [359, 406], '4′,6-diamidino-': [360, 407], '2-phenylindole;': [361, 408], 'HMW,': [362, 409], 'high': [363, 410, 2182, 3102, 5037], 'weight': [365, 412, 2184], 'complex;': [366, 413], 'DTT,': [367, 414], 'dithiothreitol;': [368, 415], 'GFP,': [369, 416], 'green': [370, 417], 'fluorescent': [371, 418], 'protein;': [372, 382, 419, 429], 'MTOC,': [373, 420], 'microtubule': [374, 421], 'organizing': [375, 422, 3139], 'center;': [376, 423], 'MT,': [377, 424], 'microtubules;': [378, 425], 'E2,': [379, 426], 'ubiquitin': [380, 427, 520, 632, 1013, 1031, 1401, 2350, 2649, 2864, 2889, 2943, 2961], 'carrier': [381, 428], 'E3,': [383, 430], 'ubiquitin-protein': [384, 431, 950], 'isopeptide': [385, 432, 951], 'ligase': [386, 433, 952, 1032], 'several': [435, 1197, 1313, 2593, 5163], 'other': [436, 2997, 4720, 5695], 'neurodegenerative': [437, 3387, 4603], 'disorders.': [438], 'progressive': [444], 'degeneration': [445], 'midbrain': [447], '(1Jenner': [450], 'P.': [451, 659, 3662, 3969, 4678, 4828, 5101, 5708], 'Olanow': [452, 4671], 'C.W.': [453, 4672], 'Ann.': [454, 2494, 4135, 4246, 4895, 5465], 'Neurol.': [455, 480, 556, 2495, 3620, 4136, 4247, 4340, 4737, 4801, 4896, 5466], '1998;': [456, 654, 799, 822, 859, 944, 2585, 3029, 3199, 3328, 3470, 3935, 4074, 4361, 4483, 4823, 5388], '44:': [457], 'S72-S84Google': [458], 'Scholar)': [459, 560, 1229, 2525, 2567, 2588, 3365, 3690, 4117, 5107, 5249, 5331, 5508, 5688], 'bodies': [470, 516, 627, 1339, 3383, 3606, 3840, 3917, 4034, 4122, 4233, 4327, 4710, 4752, 4967, 4996, 5277, 5292, 5399, 5437, 5474, 5528, 5555, 5570, 5595, 5604, 5739, 5810], '(2Pollanen': [471, 4331, 4728], 'M.S.': [472, 4332, 4729], 'Dickson': [473, 4333, 4730], 'D.W.': [474, 4334, 4731], 'Bergeron': [475, 4335, 4732], 'C.': [476, 734, 849, 1204, 3187, 4336, 4733, 5320], 'J.': [477, 539, 553, 617, 699, 708, 748, 985, 1087, 1135, 1162, 1188, 1209, 1224, 2383, 2409, 2520, 2582, 2758, 2837, 3026, 3041, 3049, 3196, 3325, 3340, 3467, 3592, 3617, 3684, 3714, 3755, 3979, 4160, 4337, 4480, 4495, 4503, 4630, 4734, 4784, 4798, 4868, 4877, 4955, 5237, 5325, 5385, 5682], 'Neuropathol.': [478, 554, 3618, 4073, 4338, 4735, 4799], 'Exp.': [479, 555, 3619, 4339, 4736, 4800], '1993;': [481, 2840, 3430, 4341, 4738], '52:': [482, 4342, 4739], '183-191Google': [483, 4343, 4740], 'Scholar).': [484, 622, 713, 862, 912, 1004, 1194, 2415, 2843, 3081, 3126, 3433, 3473, 3598, 3624, 3722, 3761, 3865, 3992, 4077, 4172, 4251, 4364, 4535, 4644, 4685, 4741, 4960, 5391, 5470, 5521, 5551, 5591], 'Although': [485], 'cause': [487, 5348], 'effect': [489, 2793], 'relationship': [490, 3213], 'between': [491, 1036, 3214, 5357, 5395], 'these': [492, 722, 1325, 2629, 2782, 2803, 2848, 2868, 2926, 3094, 3260, 3497, 3516, 4404, 4576, 5041, 5253, 5629], 'cell': [495, 1583, 1754, 2170, 2532, 5823], 'death': [496], 'remains': [497, 5632, 5825], 'unclear,': [498], 'constituents': [501, 5274], 'reveal': [504], 'clues': [505, 4597], 'events': [508], 'leading': [509, 5784], 'their': [511, 3235, 3560, 3707, 5197], 'formation.': [512, 3236], 'For': [513, 1947, 1970, 1988, 2014], 'example,': [514, 3725], 'rich': [518], 'subunits': [523, 1323, 3555, 3601], '(3Iwatsubo': [524, 4769], 'T.': [525, 587, 616, 758, 782, 804, 845, 851, 926, 971, 975, 2481, 2503, 4323, 4770, 4937], 'Yamaguchi': [526, 4771], 'H.': [527, 531, 548, 614, 676, 701, 746, 790, 810, 932, 955, 989, 1062, 1091, 1112, 1133, 1166, 2387, 2473, 2483, 2507, 2558, 3010, 3574, 3612, 3946, 3973, 4036, 4071, 4134, 4158, 4245, 4464, 4772, 4776, 4793, 4845, 4870, 4894, 4914, 4939, 5235, 5464, 5577], 'Fujikura': [528, 4773], 'M.': [529, 644, 646, 703, 786, 816, 888, 890, 938, 1110, 1185, 2406, 2479, 3681, 3925, 3927, 3975, 4065, 4069, 4128, 4239, 4346, 4356, 4636, 4774, 4813, 4815, 4872, 4888, 4931, 5458, 5679], 'Yokosawa': [530, 4775], 'Ihara': [532, 4777], 'Y.': [533, 579, 688, 812, 818, 894, 934, 940, 961, 983, 1074, 1085, 1108, 1116, 1127, 1131, 1160, 1183, 2381, 2404, 2489, 2493, 2509, 2517, 3189, 3679, 3958, 4048, 4067, 4152, 4156, 4352, 4778, 4857, 4947, 5229, 5233, 5677], 'Trojanowski': [534, 3855, 4779, 4915, 5541, 5584], 'J.Q.': [535, 3417, 3856, 4780, 4916, 5542, 5585], 'Lee': [536, 666, 1205, 1207, 3426, 3669, 3745, 3857, 3984, 4781, 4835, 4917, 5321, 5323, 5543, 5578], 'V.M.': [537, 3427, 3858, 4782, 4918, 5544, 5579], 'Am.': [538, 4783, 4954], 'Pathol.': [540, 709, 3429, 4785, 4878, 4956], '1996;': [541, 4786], '148:': [542, 4787], '1517-1529Google': [543, 4788], 'Scholar,': [544, 604, 657, 674, 697, 776, 802, 825, 903, 981, 1083, 1106, 1123, 1181, 1215, 2402, 2499, 3019, 3032, 3047, 3062, 3331, 3346, 3415, 3583, 3677, 3967, 4057, 4344, 4452, 4473, 4486, 4501, 4516, 4789, 4805, 4826, 4843, 4866, 4882, 4900, 4923], '4Ii': [545, 4790], 'K.': [546, 550, 969, 973, 3610, 3614, 4059, 4124, 4235, 4791, 4795, 4884, 5454, 5490], 'Ito': [547, 3611, 4792], 'Tanaka': [549, 972, 1130, 3613, 4155, 4794, 5232], 'Hirano': [551, 3615, 4796], 'A.': [552, 591, 608, 653, 684, 740, 742, 756, 847, 892, 896, 1000, 1070, 1102, 1177, 2398, 2550, 2826, 3002, 3058, 3077, 3185, 3361, 3566, 3616, 3934, 3954, 4044, 4063, 4350, 4354, 4456, 4512, 4531, 4797, 4822, 4853], '1997;': [557, 773, 3621, 4802], '56:': [558, 3622, 4803], '125-131Google': [559, 3623, 4804], 'consistent': [561, 2373, 4217, 5221], 'critical': [564, 4695], 'role': [565], 'this': [567, 1254, 2087, 2167, 2221, 2335, 2664, 2725, 2873, 3239, 4698, 5655, 5742], 'degradation': [569, 1158, 3539, 3710, 4661], 'pathway': [570], 'neuronal': [572, 3846, 5630, 5794], 'homeostasis': [573], 'apoptosis': [575], '(5Tanaka': [578], 'Engelender': [580, 4125, 4236, 4885, 5455], 'Igarashi': [582], 'Rao': [584, 3424], 'R.K.': [585, 4095], 'Wanner': [586], 'Tanzi': [588], 'R.E.': [589], 'Sawa': [590], 'Dawson': [592, 594, 990, 992, 1092, 1094, 1138, 1140, 1167, 1169, 2388, 2390, 4106, 4108, 4163, 4165, 5240, 5242], 'V.L.': [593, 991, 1093, 1139, 1168, 2389, 4107, 4164, 5241], 'T.M.': [595, 993, 1095, 1141, 1170, 2391, 4109, 4166, 5243], 'Ross': [596, 1136, 4110, 4131, 4161, 4242, 4891, 5238, 5461], 'C.A.': [597, 1137, 3183, 4111, 4132, 4162, 4243, 4892, 5239, 5462], 'Hum.': [598], 'Mol.': [599, 2561, 3013, 3577, 4467], 'Genet.': [600, 798, 977, 4113], '2001;': [601, 694, 1080, 1120, 1144, 1226, 2522, 2564, 2760, 3016, 3059, 3580, 3964, 3989, 4054, 4169, 4470, 4513, 4682, 4863, 5104, 5246, 5711], '10:': [602, 1301, 3124, 4450, 5519], '919-926Google': [603], '6Qiu': [605], 'J.H.': [606], 'Asai': [607], 'Chi': [609], 'Saito': [611], 'N.': [612, 661, 680, 808, 820, 930, 942, 957, 967, 1066, 1114, 2475, 2491, 2515, 2519, 3664, 3950, 3971, 4040, 4830, 4849, 4933, 4943], 'Hamada': [613], 'Kirino': [615], 'Neurosci.': [618, 4681, 5102, 5709], '2000;': [619, 671, 900, 909, 978, 1001, 1103, 1178, 1191, 1300, 2399, 2412, 3078, 3123, 3362, 3674, 3687, 4137, 4248, 4309, 4449, 4532, 4840, 4897, 4920, 5467, 5518, 5685], '20:': [620], '259-265Google': [621], 'Other': [623, 2740, 3127], 'components': [624, 3379, 4759, 5207], 'include': [628, 3133], 'C-terminal': [633], 'hydrolase': [634], 'L1': [635], '(UCH-L1)': [636], '(7Spillantini': [637, 3918], 'M.G.': [638, 678, 1064, 2836, 3746, 3919, 3948, 4038, 4807, 4847, 4925], 'Crowther': [639, 3920, 4808], 'R.A.': [640, 3921, 4809], 'Jakes': [641, 3922, 4810], 'R.': [642, 686, 750, 778, 829, 1072, 1118, 1187, 2408, 2552, 3004, 3034, 3333, 3568, 3585, 3683, 3923, 3956, 4046, 4458, 4488, 4811, 4855, 4941, 5681], 'Hasegawa': [643, 3924, 4812], 'Goedert': [645, 3926, 4814], 'Proc.': [647, 994, 1096, 1171, 2392, 3052, 3071, 3355, 3928, 4506, 4525, 4816], 'Natl.': [648, 995, 1097, 1172, 2393, 3053, 3072, 3356, 3929, 4507, 4526, 4817], 'Acad.': [649, 996, 1098, 1173, 2394, 3054, 3073, 3357, 3930, 4508, 4527, 4818], 'Sci.': [650, 997, 1099, 1174, 2395, 3055, 3074, 3358, 3931, 4509, 4528, 4819], 'U.': [651, 998, 1100, 1175, 2396, 3056, 3075, 3359, 3932, 4510, 4529, 4820], '95:': [655, 3936, 4824], '6469-6473Google': [656, 3937, 4825], '8Choi': [658, 4827], 'Ostrerova-Golts': [660, 3663, 4829], 'Sparkman': [662, 3665, 3980, 4831], 'D.': [663, 784, 1221, 2755, 3425, 3666, 3981, 4832], 'Cochran': [664, 3667, 3982, 4833], 'E.': [665, 736, 827, 837, 882, 884, 2554, 3006, 3570, 3668, 3983, 4358, 4460, 4834], 'J.M.': [667, 3670, 3985, 4836, 4910], 'Wolozin': [668, 3671, 3986, 4837], 'B.': [669, 744, 833, 3672, 3987, 4674, 4838], 'Neuroreport.': [670, 3673, 3988, 4839], '11:': [672, 3675, 4841], '2635-2638Google': [673, 3676, 4842], '9Shimura': [675, 4844], 'Schlossmacher': [677, 1063, 3947, 4037, 4846], 'Hattori': [679, 807, 929, 956, 1065, 1113, 2474, 2518, 3949, 4039, 4848, 4942], 'Frosch': [681, 1067, 3951, 4041, 4850, 4926], 'M.P.': [682, 1068, 3952, 4042, 4851, 4927], 'Trockenbacher': [683, 1069, 3953, 4043, 4852], 'Schneider': [685, 1071, 3955, 4045, 4854], 'Mizuno': [687, 817, 939, 960, 1073, 1115, 2492, 2516, 3957, 4047, 4856, 4946], 'Kosik': [689, 1075, 3959, 4049, 4858, 4952], 'K.S.': [690, 1076, 3960, 4050, 4670, 4859, 4953, 5099, 5706], 'Selkoe': [691, 1077, 3961, 4051, 4860, 4950], 'D.J.': [692, 1078, 3962, 4052, 4861, 4951], 'Science.': [693, 772, 899, 1079, 3411, 3861, 3963, 4053, 4862, 4919, 5547, 5616], '293:': [695, 1081, 3965, 4055, 4864], '263-269Google': [696, 1082, 3966, 4056, 4865], '10Lowe': [698, 4867], 'McDermott': [700, 4869], 'Landon': [702, 4635, 4871], 'Mayer': [704, 4873], 'R.J.': [705, 4628, 4874], 'Wilkinson': [706, 854, 4875], 'K.D.': [707, 855, 4876], '1990;': [710, 4879], '161:': [711, 4880], '153-160Google': [712, 4881], 'Mutations': [714], 'cognate': [717], 'gene': [718], 'each': [720, 1893], 'linked': [725], '(11Polymeropoulos': [731], 'M.H.': [732, 857], 'Lavedan': [733, 848], 'Leroy': [735], 'Ide': [737], 'S.E.': [738], 'Dehejia': [739, 846], 'Dutra': [741], 'Pike': [743], 'Root': [745], 'Rubenstein': [747], 'Boyer': [749, 828], 'Stenroos': [751], 'E.S.': [752, 3040, 3339, 3591, 4494], 'Chandrasekharappa': [753], 'Athanassiadou': [755], 'Papapetropoulos': [757], 'Johnson': [759], 'W.G.': [760], 'Lazzarini': [761], 'A.M.': [762], 'Duvoisin': [763], 'R.C.': [764], 'Di': [765], 'Iorio': [766], 'G.': [767, 831, 835, 839, 2556, 3008, 3572, 4462, 4632], 'Golbe': [768], 'L.I.': [769], 'Nussbaum': [770], 'R.L.': [771, 4099], '276:': [774], '2045-2047Google': [775], '12Kruger': [777], 'Kuhn': [779], 'W.': [780, 3181, 3191], 'Muller': [781], 'Woitalla': [783], 'Graeber': [785], 'Kosel': [787], 'Przuntek': [789], 'Epplen': [791], 'J.T.': [792], 'Schols': [793], 'L.': [794, 898, 1223, 2757, 2828, 3977, 4935], 'Riess': [795], 'O.': [796, 2834, 4676], 'Nat.': [797, 976, 1142, 4112, 4167, 4679, 5244], '18:': [800], '106-108Google': [801], '13Kitada': [803], 'Asakawa': [805, 927, 962, 2484, 2510], 'Matsumine': [809, 931, 2482], 'Yamamura': [811, 933, 2488], 'Minoshima': [813, 935, 964, 2486, 2512], 'Yokochi': [815, 937], 'Shimizu': [819, 941, 966, 2490, 2514], 'Nature.': [821, 858, 908, 943], '392:': [823, 945], '605-608Google': [824, 946], '14Leroy': [826], 'Auburger': [830], 'Leube': [832], 'Ulm': [834], 'Mezey': [836], 'Harta': [838], 'Brownstein': [840], 'M.J.': [841, 3066, 3350, 4520], 'Jonnalagada': [842], 'Chernova': [844], 'Gasser': [850], 'Steinbach': [852], 'P.J.': [853, 3754], 'Polymeropoulos': [856], '395:': [860], '451-452Google': [861], 'Additionally,': [863, 2592, 3496, 3599, 4324, 5308], 'transgenic': [868, 3850], 'models': [869], 'results': [870, 1308, 5258, 5661], 'locomotor': [879], 'dysfunction': [880, 2788, 5310], '(15Masliah': [881], 'Rockenstein': [883], 'Veinbergs': [885], 'I.': [886], 'Mallory': [887], 'Hashimoto': [889], 'Takeda': [891, 4353], 'Sagara': [893], 'Sisk': [895, 4349], 'Mucke': [897], '287:': [901], '1265-1269Google': [902], '16Feany': [904], 'M.B.': [905], 'Bender': [906], 'W.W.': [907], '404:': [910], '394-398Google': [911], 'originally': [914, 4079], 'identified': [915, 4080, 4749], 'positional': [917], 'cloning': [918], 'families': [920], 'autosomal': [922], 'recessive': [923], '(13Kitada': [925], 'Scholar),': [947, 1147, 1303, 2763, 3202, 3938, 4140, 4312, 5620, 5714], '(E3)': [953], '(17Shimura': [954], 'Kubo': [958, 2476], 'Iwai': [968], 'Chiba': [970], 'Suzuki': [974], '25:': [979], '302-305Google': [980], '18Zhang': [982, 1084], 'Gao': [984, 1086, 1134, 1161, 2382, 4159, 5236], 'Chung': [986, 1088, 1163, 2384], 'K.K.': [987, 1089, 1125, 1164, 2385, 4150, 5227], 'Huang': [988, 1090, 1132, 1165, 2386, 4157, 5234], '97:': [1002, 1104, 1179, 2400, 3079, 3363, 4533], '13354-13359Google': [1003, 1105, 1180, 2401], 'This': [1005], '465-amino': [1006], 'acid': [1007], 'has': [1009, 3525, 3726, 4028, 4440, 4747, 4989, 5311], 'mild': [1010], 'homology': [1011], 'at': [1014, 1024, 1671, 1675, 1879, 1907, 2041, 2807, 3136, 3225], 'its': [1015, 1025, 1030, 1037, 1156, 2669, 3134, 3795, 3883, 5014, 5119, 5691, 5777, 5789, 5842], 'N': [1016], 'terminus': [1017], 'contains': [1019, 2253, 2337], 'RING': [1021, 1038], 'finger': [1022, 1039], 'domains': [1023], 'C': [1026, 4270], 'terminus.': [1027], 'exerts': [1029], 'function': [1033, 3740, 5171], 'through': [1034, 3308], 'interactions': [1035], 'domain': [1040], 'E2-conjugating': [1042], 'enzymes.': [1043], 'In': [1044, 1253, 3546, 4981, 5121, 5763], 'addition': [1045], 'ubiquitinating': [1047], 'number': [1049], 'substrate': [1051], 'such': [1053, 1316, 2745, 2973, 3243, 3400, 3448, 3774, 4318], 'CDCrel-1,': [1055], 'glycosylated': [1056], 'Pael-R,': [1058], 'synphilin-1': [1060, 1478, 4175, 4190, 4206, 4223, 4257, 5215], '(9Shimura': [1061, 3945, 4035], '19Imai': [1107], 'Soda': [1109, 1184, 2405, 3680, 5678], 'Inoue': [1111], 'Takahashi': [1117, 1186, 2407, 3682, 4070, 4133, 4244, 4893, 5463, 5680], 'Cell.': [1119, 2563, 3015, 3579, 4469], '105:': [1121], '891-902Google': [1122], '20Chung': [1124], 'Zhang': [1126, 4151, 5228], 'Lim': [1128, 4153, 5230], 'K.L.': [1129, 4154, 5231], 'Med.': [1143, 4168, 5245], '7:': [1145, 4170, 5247], '1144-1150Google': [1146, 4171, 5248], 'ubiquitinates': [1149], 'itself': [1150], 'an': [1152, 2639, 2795, 3297, 3506, 3530, 3873, 4082], 'early': [1153], 'step': [1154], 'proteasome-mediated': [1157], '(18Zhang': [1159, 2380], '21Imai': [1182, 2403, 3678], 'Biol.': [1189, 1210, 1299, 2410, 2562, 2584, 2839, 3014, 3028, 3043, 3122, 3198, 3327, 3342, 3469, 3578, 3594, 3685, 3718, 3757, 4448, 4468, 4482, 4497, 4639, 5326, 5517, 5683], 'Chem.': [1190, 1211, 2411, 3686, 5327, 5386, 5684], '275:': [1192, 2413, 3688, 5686], '35661-35664Google': [1193, 2414, 3689, 5687], 'To': [1195, 2153, 2416, 2872, 3142, 3237, 3625, 3781], 'date,': [1196], 'studies': [1198, 2800, 3156], '(22Lee': [1199, 5315], 'H.J.': [1200, 1217, 2751, 5316], 'Shin': [1201, 3420, 5317], 'S.Y.': [1202, 5318], 'Choi': [1203, 5319], 'Y.H.': [1206, 5322], 'S.J.': [1208, 3195, 5324], '2002;': [1212, 3862, 4957, 5328, 5548], '277:': [1213, 5329], '5411-5417Google': [1214, 5330], '23Rideout': [1216], 'Larsen': [1218, 2752], 'K.E.': [1219, 2753], 'Sulzer': [1220, 2754], 'Stefanis': [1222, 2756], 'Neurochem.': [1225, 2521, 2759], '78:': [1227, 2523, 2761], '899-908Google': [1228, 2762], 'addressed': [1231], 'inclusions,': [1240, 1950, 2967, 5220, 5774], 'but': [1241, 5754], 'ability': [1248], 'aggregate.': [1252], 'report,': [1255, 4984], 'inhibitor': [1268, 1813, 2317, 2680, 3480], 'single,': [1277, 5352], 'large,': [1278, 2693], 'peri-nuclear': [1280, 2447, 2695, 2966, 2984, 3145, 3273, 3521, 4178, 5176, 5808], 'consisting': [1282], 'halo.': [1288], 'structures': [1290, 1353, 5177, 5302, 5631], 'aggresomes': [1294, 3307, 3441, 3562, 3629, 3655, 3763, 3896, 4017, 4179, 4260, 4396, 4424, 5396, 5598], '(24Kopito': [1295, 3118, 4444, 5513], 'R.R.': [1296, 2581, 3025, 3070, 3119, 3324, 3354, 3466, 4445, 4479, 4524, 5514], 'Trends': [1297, 3120, 4446, 5515], 'Cell': [1298, 2583, 2838, 3027, 3042, 3121, 3197, 3326, 3341, 3468, 3593, 3756, 4447, 4481, 4496, 5516], '524-530Google': [1302, 3125, 4451, 5520], 'which': [1307, 2257, 3941, 4313, 5559], 'redistribution': [1311], 'cellular': [1314, 4979, 5344, 5659], 'factors,': [1315], 'intermediate': [1318, 3397, 3446, 4625], 'filaments,': [1319], 'inclusion': [1326, 2611, 2696, 3382, 3522, 4995, 5126, 5809], 'Based': [1328], 'on': [1329, 2208, 2977, 3115], 'our': [1330, 5055, 5129, 5404], 'observations,': [1331, 4593], 'suggest': [1333, 2655, 3295, 5740], 'brains': [1342, 3843, 5704], 'patients': [1345], 'when': [1354, 2660, 4575, 4581, 4997, 5074, 5303, 5811], 'activity': [1356, 3090, 5092, 5305, 5698, 5813], 'impaired.': [1358, 5815], 'following': [1360], 'antibodies': [1361, 1897], 'were': [1362, 1385, 1430, 1493, 1585, 1599, 1616, 1631, 1639, 1669, 1686, 1700, 1736, 1756, 1784, 1821, 1857, 1868, 1886, 1898, 1914, 1954, 1975, 1994, 2028, 2048, 2081, 2091, 2129, 2144, 2162, 2597, 2709, 2877, 3157, 3249, 3802, 3835], 'immunofluorescence': [1365, 2899, 3277], 'studies.': [1366], 'Mouse': [1367, 1389], 'monoclonal': [1368, 1380, 1390], 'anti-FLAG': [1369, 1374, 1740], '(M2)-fluorescein': [1370], 'isothiocyanate': [1371], 'conjugate': [1372, 1376, 1392], '(1:200),': [1373, 1377, 1408, 1413, 1418, 1480, 1485], '(M2)-Cy3': [1375], 'mouse': [1379, 1762], 'γ-tubulin': [1381, 5625], '(GTU-88)': [1382], 'antibody': [1383, 1397, 1402, 1407, 1412, 1417, 1442, 1455, 1471, 1479, 1484, 1491, 1764, 1872, 1986, 2012, 2247, 2362, 2641, 2944], '(1:1000)': [1384], 'purchased': [1386, 1431], 'from': [1387, 1432, 1446, 1458, 1474, 1494, 1551, 3164, 4194, 5155, 5562], 'Sigma.': [1388], 'anti-HA-TRITC': [1391], '(1:100),': [1393, 1398, 1403], 'rabbit': [1394, 1399, 1409, 1481, 1487], 'polyclonal': [1395, 1400, 1405, 1410, 1415, 1440, 1453, 1465, 1477, 1482, 1488], 'vimentin': [1396, 3489, 3827, 5627], 'goat': [1404, 1414, 1424], 'BIP/GRP78': [1406, 2546, 3893], 'γ-adaptin': [1411, 2464], 'LAMP-1': [1416, 2575], 'secondary': [1420, 1985], 'donkey': [1421], 'anti-rabbit': [1422], 'or': [1423, 1752, 1781, 1942, 2733, 3086, 3543, 3709, 4580, 4649, 4656, 5059, 5844], 'IgG': [1425], 'conjugated': [1426], 'rhodamine': [1428], '(1:200)': [1429, 1443, 1456, 1492], 'Santa': [1433, 1769], 'Cruz': [1434, 1767], 'Biotechnology': [1435], '(Santa': [1436, 1766], 'Cruz,': [1437, 1770], 'CA).': [1438, 1497], 'Rabbit': [1439, 1452, 1464], 'Hsp70': [1441, 3793, 3832], 'was': [1444, 1457, 1473, 1501, 1547, 1565, 1724, 1815, 1963, 2077, 2275, 2428, 2443, 2613, 2928, 3278, 3798, 4008, 4261, 5132], 'obtained': [1445], 'Upstate': [1447], 'Biotechnology,': [1448, 1768], 'Inc.': [1449], '(Waltham,': [1450], 'MA).': [1451], 'Hsp40': [1454, 3834], 'Stressgen': [1459], '(Victoria,': [1460], 'British': [1461], 'Columbia,': [1462], 'Canada).': [1463], 'α-subunit': [1466, 3651], '20': [1468, 1662, 1829, 1865, 2271, 3640], 'S': [1469, 1990, 1999, 3641, 4321, 4388], '(1:250)': [1472], 'Calbiochem.': [1475], 'Goat': [1476], 'mannosidase': [1489, 2457, 2823], 'II': [1490, 2458, 2824], 'Chemicon': [1495], '(Temecula,': [1496], 'Full-length': [1498], 'cDNA': [1500, 1546, 1555, 2160, 2882], 'amplified': [1502, 1563], 'PCR': [1504, 1550], 'using': [1505, 1557, 1618, 1664, 1761, 1790], 'primers': [1506, 1511, 1558], '5′-GCCGAATTCACCATGATAGTGTTTGTCAGGTTC-3′': [1507], '5′-GGCGGATCCCTACACGTCGAACCAGTGG-3′.': [1509], 'contained': [1512], 'additional': [1513, 3154], 'restriction': [1514], 'enzyme': [1515], 'cleavage': [1516], 'sites': [1517], 'facilitate': [1519, 3706], 'insertion': [1520], 'product': [1523], 'pFLAG-CMV-2': [1525], '(Sigma)': [1526, 1742, 2000], 'express': [1528, 1539, 1573], 'FLAG-': [1529], 'tagged': [1530], 'pEGFP-C2': [1533], '(Clontech,': [1534], 'Palo': [1535], 'Alto,': [1536], 'CA)': [1537, 1771, 2040], 'GFP-Parkin,': [1540], 'pcDNA3.1': [1543], '(Invitrogen).': [1544], 'Ubiquitin': [1545], 'isolated': [1548], 'human': [1552, 1578, 2528], 'adult': [1553], 'brain': [1554, 2529, 4721, 5644], 'library': [1556], '5′-GGAAGCTTAATGCAGATCTTCGTGAAGACTCTG-3′': [1559], '5′-GGCGAATTCTACCCACCCTGAGACGGAGTAC-3′.': [1561], 'sequence': [1564], 'inserted': [1566], 'into': [1567, 4994, 5351, 5773, 5806], 'pHM6': [1568], '(Roche': [1569, 1622, 1656, 1718], 'Molecular': [1570, 1623, 1657, 1719, 3699], 'Biochemicals)': [1571, 1624], 'HA-tagged': [1574, 2888], 'ubiquitin.': [1575], 'COS-7': [1576, 1782, 2021, 2218, 2437, 2675, 2712, 2735, 2875, 2958], 'embryonic': [1579], 'kidney': [1580], 'HEK': [1581, 1779, 2172, 2327, 2718], '293T': [1582, 1780, 2173, 2328, 2719], 'lines': [1584], 'maintained': [1586], "Dulbecco's": [1588, 1602], 'modified': [1589, 1603, 2348], "Eagle's": [1590, 1604], 'medium': [1591, 1605], 'containing': [1592, 1606, 1644, 1712, 2986, 3523, 4615, 5293], '10%': [1593, 1607], 'fetal': [1594, 1612], 'serum.': [1596, 1614], 'PC12': [1597, 2233], 'cells': [1598, 1668, 1783, 1850, 1962, 1967, 1974, 1993, 2022, 2027, 2068, 2080, 2090, 2174, 2219, 2234, 2329, 2604, 2637, 2676, 2689, 2713, 2720, 2736, 2774, 2876, 2959, 3092, 3475, 3900, 4385, 4559, 4583, 5161, 5167, 5185, 5257, 5382], 'cultured': [1600, 1632, 1785], 'horse': [1608], '5%': [1611], 'Transfections': [1615], 'performed': [1617, 1737], 'FuGENE': [1619, 1791], '6': [1620, 1792], 'reagent': [1621, 1775], 'according': [1625], "supplier's": [1628], 'instructions.': [1629], 'Cells': [1630, 1638, 1820, 1867, 1885, 1913, 2047, 2128], '24': [1634], 'h': [1635], 'after': [1636, 1984, 3505], 'transfection.': [1637], 'lysed': [1640], 'buffer': [1643, 1704, 1732, 1748], 'PBS': [1645, 1827, 1833, 1843, 1853, 1863, 1875, 1901, 2031], '1%': [1647, 1707, 1710, 1860, 1877, 1903, 5027], 'Triton': [1648, 1697, 1708, 1840, 2192, 2203, 2279, 2619, 5035], 'X-100': [1649, 1841], 'mixture': [1652, 1714], 'protease': [1654, 1716], 'Biochemicals).': [1658, 1720], 'After': [1659, 1721, 1847, 2065, 2086, 2671], 'homogenizing': [1660], 'strokes': [1663], 'Dounce': [1666], 'homogenizer,': [1667], 'centrifuged': [1670], '100,000': [1672], '×': [1673], 'g': [1674, 2111], '4': [1676, 1880, 1908, 3256, 3291, 3512, 3829], '°C': [1677, 1881, 1909], '30': [1679], 'min.': [1680, 1846, 1866, 2046, 2085, 2127], 'soluble': [1682], 'fractions': [1685, 2207], 'Western': [1689, 1759, 2209, 2286, 2353, 4265], 'blots': [1690, 1760, 2210], 'FLAG,': [1692], 'synphilin-1.': [1695], 'X-100-insoluble': [1698, 2193, 2280, 2620, 5036], 'pellets': [1699], 'dissolved': [1701], '(PBS': [1705], 'plus': [1706], 'X-100,': [1709], 'SDS)': [1711], 'centrifugation,': [1722], 'supernatant': [1723], 'diluted': [1725, 1873, 1899], '10×': [1727], 'volume': [1728], 'same': [1731, 2636, 3483, 5414], 'lacking': [1733], 'SDS.': [1734], 'Immunoprecipitations': [1735], 'agarose-conjugated': [1739], '(M2)': [1741], 'followed': [1743, 2105, 2890], 'washing': [1745, 1848], 'lysis': [1747], 'four': [1749], 'times.': [1750], 'Immunoprecipitates': [1751], 'total': [1753], 'lysates': [1755], 'analyzed': [1757, 1934, 2148, 2955, 3635, 3868], 'anti-ubiquitin': [1763, 2361, 2640], '(P4D1)': [1765], 'ECL': [1773], 'detection': [1774], '(PerkinElmer': [1776], 'Life': [1777], 'Sciences).': [1778], '60-mm': [1787], 'plates,': [1788], 'transfected': [1789, 1966, 2024, 2175, 2616, 2688, 2773], 'transfection': [1793], 'kit,': [1794], 'plated': [1796], 'collagen-coated': [1798], 'Biocoat®': [1799], 'slides': [1800], '(BD': [1801], 'Biosciences)': [1802], '1': [1804, 1911, 2126, 2212, 2300, 2331, 2371], 'day.': [1805], 'Before': [1806], 'staining,': [1807, 1972, 1991], '5': [1808, 1845, 1891, 1982, 2002], 'μm': [1809], 'MG-132': [1814, 2318, 2681, 2894, 3510, 3890, 5151], 'added': [1816, 2276], '16': [1818], 'h.': [1819, 1884, 1912, 2897], 'fixed': [1822, 1973, 1992], '4%': [1824], 'formaldehyde': [1825], 'min,': [1830, 2104], 'washed': [1831, 1887, 1915, 2005, 2029, 2092, 2131], 'three': [1834, 1854, 2009, 2054, 2133, 5254, 5267], 'times,': [1835, 1855], 'permeabilized': [1837], '0.6%': [1839], 'again': [1851, 2069, 2093], 'they': [1856, 3503], 'blocked': [1858], 'BSA': [1861, 1878, 1904], 'incubated': [1869, 1906, 1976, 1995, 2034, 2082], 'primary': [1871], '2': [1883, 2569, 2590, 2651], 'five': [1888, 1916], 'times': [1889, 1917, 2010, 2055], 'min': [1892, 1983, 2003], 'PBS.': [1895], 'Secondary': [1896], 'mounted': [1920], 'ProLong®': [1922], 'antifade': [1923], 'mounting': [1924], 'material': [1925], '(Molecular': [1926], 'Probes,': [1927], 'Eugene,': [1928], 'OR)': [1929], 'under': [1930, 1935, 2149], 'coverglass,': [1932], 'Zeiss': [1937], '(LSM': [1938], '510)': [1939], 'confocal': [1940], 'microscope': [1941, 1944], 'epi-fluorescence': [1943], '(Zeiss,': [1945], 'Axiophot).': [1946], 'quantification': [1948], '10': [1951, 1978], 'microscopic': [1952], 'fields': [1953], 'randomly': [1955], 'selected,': [1956], 'percentage': [1959], 'inclusion-positive': [1961], 'counted': [1964], 'among': [1965], 'expressing': [1968, 2714, 2721, 3093, 4560], 'FLAG-Parkin.': [1969], 'nuclear': [1971, 2705], 'μm4′,6-diamidino-2-phenylindole': [1979], '(DAPI)': [1980], 'incubation.': [1987], '0.1%': [1997], '70%': [2007, 2100, 2123], 'ethanol': [2008, 2101, 2137], 'before': [2011], 'staining.': [2013], 'H': [2015, 4417], '&': [2016, 4418], 'E': [2017, 4419], 'MG-132-treated': [2020, 2957, 4286], 'transiently': [2023, 2165, 2878], 'FLAG-Parkin,': [2026, 2722], 'twice': [2032], 'hematoxylin': [2036], '(Vector': [2037], 'Laboratories,': [2038], 'Burlingame,': [2039], 'room': [2042], 'temperature': [2043], '3': [2045, 2084, 2103, 2913, 2951], 'then': [2049, 2130, 2341], 'rinsed': [2050], 'deionized': [2052, 2071, 2095], 'water': [2053, 2096], 'destained': [2057], 'acidic': [2059], 'alcohol': [2060], 'few': [2063], 'seconds.': [2064], 'rinsing': [2066], 'water,': [2072], 'bicarbonate': [2073], 'solution': [2074], '(1': [2075], 'g/liter)': [2076], 'added,': [2078], 'bluing': [2088], 'step,': [2089], 'placed': [2098], 'eosin': [2109], '(0.5': [2110], 'Eosin': [2113], 'Y,': [2114], '2.5': [2115], 'ml': [2116, 2121], 'acetic': [2118], 'acid,': [2119], '500': [2120], 'ethanol)': [2124], 'changes': [2134], '95%': [2136], 'dehydrated': [2139], 'absolute': [2141], 'ethanol.': [2142], 'Slides': [2143], 'dried,': [2145], 'mounted,': [2146], 'light': [2151], 'microscope.': [2152], 'investigate': [2154, 3626, 3782, 4971], 'constructs': [2161], 'overexpress': [2166], 'lines.': [2171, 2533], 'N-terminally': [2177], 'FLAG-tagged': [2178, 2731], 'expressed': [2180], 'complex': [2185, 2243, 2298, 2306, 2325, 2336, 2450, 2810, 2857, 3534, 5365], '(HMW)': [2186], 'detected': [2189, 2200, 2444, 2598, 3558, 3803, 4174, 4557, 5053, 5217], 'fraction': [2194, 2281, 4284], 'monomeric': [2198], 'both': [2202, 2527, 3205, 5408, 5593], 'X-100-soluble': [2204], '-insoluble': [2206], '(Fig.': [2211, 2299, 2330, 2370, 2568, 2589, 2650, 2912, 2950, 3255, 3290, 3511, 3816, 3828, 4268, 4409, 4427], 'A).': [2213, 3220, 4022, 4411], 'Expression': [2214], 'FLAG-Parkin': [2216, 2358, 2435, 2442, 2623, 2881, 2923, 3276], 'reproduced': [2220], 'finding': [2222], '(data': [2223, 2248, 2737], 'not': [2224, 2249, 2308, 2728, 2738, 5572, 5750, 5765], 'shown).': [2225, 2250, 2739], 'Similarly,': [2226, 3434], 'expression': [2228, 2433, 5675], 'non-tagged': [2230], 'also': [2235, 2535, 2647, 2861, 2954, 3630, 3867, 3942, 4029, 4141, 4262, 4369, 5001, 5270, 5530], 'led': [2236], 'HMW': [2242, 2297, 2305, 2324, 2366, 4274, 5042], 'recognized': [2244, 4435], 'Because': [2251, 2618, 3762, 4365, 5078], '35': [2254], 'cysteine': [2255], 'residues,': [2256], 'vulnerable': [2259], 'oxidation': [2261, 2311], 'tend': [2263], 'intra-': [2266], 'inter-molecular': [2268], 'disulfide': [2269], 'bridges,': [2270], 'mm': [2272], 'dithiothreitol': [2273], '(DTT)': [2274], 'onto': [2277], 'boiled': [2283], 'prior': [2284], 'blotting.': [2287], 'DTT': [2288], 'treatment': [2289, 2672, 2892, 5136, 5152], 'failed': [2290], 'inhibit': [2292, 4589], 'B),': [2301, 2468, 2776], 'suggesting': [2302, 2333, 4402, 5004], 'does': [2307], 'represent': [2309], 'products.': [2312], 'Incubation': [2313], 'increased': [2319, 5134], 'amount': [2321], 'A),': [2332, 3657], 'ubiquitin-conjugated': [2338], 'proteins.': [2339, 3545], 'examined': [2342], 'if': [2343, 5830], 'could': [2345, 3776, 5044, 5108, 5689, 5780], 'covalently': [2347], 'well.': [2352, 5762], 'blot': [2354, 4266], 'analysis': [2355], 'immunoprecipitate': [2359], 'showed': [2363], 'bands': [2367], 'ubiquitin-positive': [2369, 5263, 5668], 'C),': [2372, 3820, 3892], 'previous': [2375, 3659, 4220], 'showing': [2377, 3485], 'ubiquitination': [2379], 'study': [2417], 'distribution': [2422, 3637, 3791], 'aggregated': [2424, 3492], 'fluorescence': [2426, 3163], 'microscopy': [2427, 2900], 'employed': [2429, 3250], 'detect': [2431], 'cells.': [2438, 2617, 4287, 5146], 'Following': [2439], 'transient': [2440], 'transfection,': [2441], 'Golgi': [2449, 2809, 2821, 2856], 'regions': [2451, 4722], 'demonstrated': [2453, 2812, 3317], 'co-localization': [2455, 2815, 3155, 3648], 'trans-Golgi': [2461], 'network': [2462], 'marker': [2463, 2545, 2574, 2822, 3174], '(Fig.2,': [2465], 'A': [2466, 4023, 4742], 'reported': [2470, 5314, 5477], 'previously': [2471, 3318], '(25Shimura': [2472], 'Yoshikawa': [2478], 'Kitada': [2480], '1999;': [2496, 3044, 3343, 3595, 3758, 4114, 4498], '45:': [2497], '668-672Google': [2498], '26Kubo': [2500], 'S.I.': [2501], 'Kitami': [2502], 'Noda': [2504], 'Shimura': [2506, 4938], 'Uchiyama': [2508], '42-54Google': [2524], 'tissue': [2530], 'co-localized': [2540, 3902], 'endoplasmic': [2543, 3874], 'reticulum': [2544, 3875], '(27Waelter': [2547, 2999, 3563], 'Boeddrich': [2549, 3001, 3565, 4455], 'Lurz': [2551, 3003, 3567, 4457], 'Scherzinger': [2553, 3005, 3569, 4459], 'Lueder': [2555, 3007, 3571, 4461], 'Lehrach': [2557, 3009, 3573, 4463], 'Wanker': [2559, 3011, 3575, 4465], 'E.E.': [2560, 3012, 3576, 4466], '12:': [2565, 3017, 3581, 3990, 4471], '1393-1407Google': [2566, 3018, 3582, 4472], 'C)': [2570], 'lysosomal': [2573], '(28Johnston': [2576, 3319, 3461], 'J.A.': [2577, 3021, 3064, 3320, 3348, 3462, 4475, 4518], 'Ward': [2578, 3022, 3321, 3463, 4476], 'C.L.': [2579, 3023, 3322, 3464, 4477, 5492], 'Kopito': [2580, 3024, 3069, 3323, 3353, 3465, 4478, 4523], '143:': [2586, 3030, 3329, 3471, 4484], '1883-1898Google': [2587, 3031, 3330, 3472, 4485], 'D).': [2591, 3495, 3830, 3909], 'small': [2594, 5048, 5187], 'spherical': [2595], 'throughout': [2599, 3280, 5190], 'cytoplasm': [2601, 3282], '(Fig.2': [2605, 3891], 'E).': [2606, 2652, 2952, 3513], 'relative': [2608, 5018], 'frequency': [2609, 5019, 5124], '0.7%': [2614], 'ubiquitin-positive,': [2625], 'investigated': [2627, 2862], 'whether': [2628, 2863, 3144, 3627, 3783], 'ubiquitinated.': [2632, 2920], 'Staining': [2633], 'revealed': [2642, 2801, 2901, 2945, 3203, 4421], 'most': [2644], 'Parkin-positive': [2645, 2917, 5817], 'contain': [2648, 3764, 3943, 5002, 5573, 5605], 'observations': [2654, 3517, 5282, 5798], 'can': [2658, 4595, 5347], 'overexpressed': [2661, 4579], 'ubiquitination.': [2670, 5015], 'FLAG-Parkin-transfected': [2674, 3474], '15': [2683, 2896], 'h,': [2684], '20%': [2686, 5143], 'manifested': [2690], 'single': [2692, 3271, 4548, 5174], 'round,': [2694], '(Fig.3': [2697, 2775, 2858], 'A)': [2698], 'appeared': [2700], 'impinge': [2702], 'upon': [2703, 3736, 5135], 'envelope.': [2706], 'Similar': [2707], 'observed': [2710, 3279, 4031], 'GFP-Parkin': [2715], 'indicating': [2723, 2777, 2915, 3209], 'unique': [2729, 2792], 'proteasome,': [2744, 3633, 5084], 'lactacystin': [2747], 'PSI': [2749], '(23Rideout': [2750], 'induced': [2764], '∼15–20%': [2771], 'due': [2785, 4653, 5366], 'proteasomal': [2787, 3739, 5091, 5170, 5304, 5697, 5812], 'rather': [2789], 'than': [2790, 5026], 'individual': [2796], 'drug.': [2797], 'Double': [2798, 2898], 'immunocytochemical': [2799, 5057], 'localized': [2806, 4010, 5480], 'significant': [2814], '(29Velasco': [2825], 'Hendricks': [2827], 'Moremen': [2829], 'K.W.': [2830], 'Tulsiani': [2831], 'D.R.': [2832], 'Touster': [2833], 'Farquhar': [2835], '122:': [2841], '39-51Google': [2842], 'Notably,': [2844], 'disrupts': [2850], 'normal': [2852], 'morphology': [2853], 'C).': [2859, 3292], 'present': [2866, 4983, 5208, 5405, 5736], 'peri-nuclear,': [2869], 'Parkin-containing': [2870, 3306, 3628, 3879, 4259, 4367, 4423, 5210, 5219, 5597, 5722], 'end,': [2874], 'co-transfected': [2879], 'together': [2883, 3251], 'plasmid': [2886], 'encoding': [2887], 'majority': [2904], 'FLAG-positive': [2906], 'co-localize': [2908], 'HA': [2910], 'D),': [2914, 4272], 'Specificity': [2921], 'verified': [2929], 'pre-adsorption': [2931], 'FLAG': [2933], 'peptide': [2934], 'resulting': [2935], 'absence': [2937, 3888], 'signal,': [2939], 'whereas': [2940, 5180], 'immunocytochemistry': [2941], 'positive': [2946], 'non-Parkin-transfected,': [2956], 'immunostaining': [2962], 'implying': [2968], 'dependent': [2976], 'large': [2983, 3111, 3272, 4549, 5175, 5353, 5807], 'had': [2988], 'marked': [2989], 'similarities': [2990, 5394], 'structures,': [2992], 'termed': [2993], 'aggresomes,': [2994, 3153, 3789, 5179, 5340], 'formed': [2995, 5149], '28Johnston': [3020, 4474], '30Garcia-Mata': [3033, 3332, 3584, 4487], 'Bebok': [3035, 3334, 3586, 4489], 'Z.': [3036, 3335, 3587, 4089, 4490], 'Sorscher': [3037, 3336, 3588, 4491], 'E.J.': [3038, 3337, 3589, 4492], 'Sztul': [3039, 3338, 3590, 4493], '146:': [3045, 3344, 3596, 4499], '1239-1254Google': [3046, 3345, 3597, 4500], '31Ma': [3048, 4502], 'Lindquist': [3050, 4504], '98:': [3060, 4514], '14955-14960Google': [3061, 4515], '32Johnston': [3063, 3347, 4517], 'Dalton': [3065, 3349, 4519], 'Gurney': [3067, 3351, 4521], 'M.E.': [3068, 3352, 4522], '12571-12576Google': [3080, 3364, 4534], 'Overexpression': [3082], 'certain': [3084, 4602, 5836], 'inhibition': [3087, 3254, 3737], 'stable,': [3101], 'weight,': [3104], 'detergent-insoluble,': [3105], 'multiubiquitinated': [3107], 'structure': [3112, 3151, 4213, 4293, 4437, 4550, 5434], 'located': [3113, 4208], 'peri-nuclearly': [3114], 'one': [3116, 3435], 'side': [3117], 'characteristic': [3128, 3438], 'features': [3129, 3439, 4375, 4408], 'aggresome': [3132, 3216, 3224, 3809, 4212, 4368, 4439, 5363, 5442, 5512], 'centrosome/microtubule': [3138], 'center': [3140], '(MTOC).': [3141], 'assess': [3143], 'carried': [3158], 'out.': [3159], 'Comparison': [3160], 'pattern': [3170, 3825, 3885, 4188], 'γ-tubulin,': [3172, 5200], 'centrosome/MTOC': [3177, 3227, 3289], '(33Dictenberg': [3178], 'J.B.': [3179], 'Zimmerman': [3180], 'Sparks': [3182], 'Young': [3184], 'Vidair': [3186], 'Zheng': [3188], 'Carrington': [3190], 'Fay': [3192], 'F.S.': [3193], 'Doxsey': [3194], '141:': [3200], '163-174Google': [3201], 'signals': [3206], 'co-localized,': [3208], 'close': [3211], 'centrosome': [3218, 5376], '(Fig.4': [3219, 3494], 'suggests': [3228], 'direct': [3229], 'involvement': [3230], 'microtubules': [3232, 3315, 5373], '(MT)': [3233], 'address': [3238], 'link,': [3240], 'MT-disrupting': [3241], 'drugs,': [3242], 'nocodazole': [3245], 'vinblastine': [3247], 'sulfate,': [3248], 'B).': [3257, 4184, 4429], 'Treatment': [3258], 'drugs': [3261, 4587], 'markedly': [3262, 5133], 'abrogated': [3263], 'MG-132-induced': [3265], 'aggresome.': [3274, 3531], 'Rather,': [3275], 'obvious': [3285], 'concentration': [3286], 'near': [3287], 'data': [3294], 'intact': [3298], 'MT': [3299], 'required': [3301], 'retrograde': [3309], 'transport': [3310], 'misfolded': [3312, 3544, 3765, 4544], 'along': [3314], 'cystic': [3368, 4561], 'fibrosis': [3369, 4562], 'transmembrane': [3370, 4563], 'conductance': [3371, 4564], 'regulator,': [3372, 4565], 'GFP-250,': [3373, 3553, 4567], 'superoxide': [3375, 4570], 'dismutase.': [3376], 'Among': [3377], 'diseases,': [3388], 'Parkinson': [3390], 'Alzheimer,': [3392], 'deposits': [3394], 'abnormal': [3396], 'filament': [3398], 'neurofilaments': [3402], '(34Goldman': [3403, 5608], 'J.E.': [3404, 4904, 5609], 'Yen': [3405, 5610], 'S.H.': [3406, 5611], 'Chiu': [3407, 5612], 'F.C.': [3408, 5613], 'Peress': [3409, 5614], 'N.S.': [3410, 5615], '1983;': [3412, 5617], '221:': [3413, 5618], '1082-1084Google': [3414, 5619], '35Trojanowski': [3416], 'Schmidt': [3418], 'M.L.': [3419], 'R.W.': [3421], 'Bramblett': [3422], 'G.T.': [3423], 'Brain': [3428, 4359, 5586], '3:': [3431], '45-54Google': [3432], 'deposition': [3444, 4542], 'filaments': [3447, 4626], 'vimentin,': [3450, 5201], 'particularly': [3451], 'redistributed': [3452, 3894], 'aggresomal': [3455], 'region': [3456, 5484], 'forming': [3457, 3810], 'ring-like': [3459], 'treated': [3476, 4585], 'elicited': [3481], 'response,': [3484], 'ring': [3487, 3812], 'around': [3491, 3813, 4018], 'quite': [3500], 'stable': [3501], 'persist': [3504], '8-h': [3507], 'wash-out': [3508], 'Taken': [3514], 'together,': [3515], 'structural': [3527], 'involved': [3536, 3695, 5745], 'incompletely': [3541], 'folded': [3542], 'case': [3548], 'mutant': [3550, 4568, 4650], 'huntingtin': [3551], 'been': [3557, 3727, 4030, 4442, 4556, 4748, 5313, 5401, 5476, 5531], 'respective': [3561, 4278], '(4Ii': [3609], 'recruit': [3631], 'α-subunit.': [3643], 'As': [3644], 'expected,': [3645], 'within': [3654, 3878], '(Fig.5': [3656, 3908], 'supporting': [3658], '(8Choi': [3661], 'degradation.': [3698], 'chaperones': [3700, 3784, 3801], 'interact': [3701], 'aggregation-prone': [3703], 're-folding': [3708], '(36Hartl': [3711], 'F.U.': [3712], 'Martin': [3713], 'Curr.': [3715], 'Opin.': [3716], 'Struct.': [3717], '1995;': [3719], '5:': [3720], '92-102Google': [3721], 'Hsp70,': [3723, 5425], 'shown': [3728], 'recruited': [3731], 'centrosomal': [3734], 'locus': [3735], '(37Wigley': [3741], 'W.C.': [3742], 'Fabunmi': [3743], 'R.P.': [3744], 'Marino': [3747], 'C.R.': [3748], 'Muallem': [3749], 'DeMartino': [3751], 'G.N.': [3752], 'Thomas': [3753], '145:': [3759], '481-490Google': [3760], 'destined': [3767], 'degradation,': [3769], 'it': [3770, 5085], 'likely': [3772, 5646], 'complexed': [3778], 'chaperones.': [3780], 'co-chaperone,': [3796], 'Hsp40,': [3797], 'examined.': [3799], 'periphery': [3806, 4014, 5447], '5,': [3817], 'B': [3818], 'Interestingly,': [3831], 'recently': [3836, 4441, 5312], 'Drosophila(38Auluck': [3851], 'P.K.': [3852, 5538], 'Chan': [3853, 5539], 'H.Y.': [3854, 5540], 'Bonini': [3859, 5545], 'N.M.': [3860, 5546], '295:': [3863, 5549], '865-868Google': [3864, 5550], 'localization': [3870], 'BIP/GRP78,': [3872], 'resident': [3876], 'chaperone,': [3877], 'aggresomes.': [3880, 4005], 'Compared': [3881], 'inhibitor-treated': [3899], 'major': [3913, 4687, 5415], 'constituent': [3914, 5416], '39Choi': [3968], 'Golts': [3970], 'Snyder': [3972], 'Chong': [3974], 'Petrucelli': [3976], 'Hardy': [3978], '2839-2843Google': [3991], 'findings': [3994, 5725], 'prompted': [3995, 4968], 'us': [3996, 4969, 5284], 'examine': [3998], 'primarily': [4011, 4226], '(Fig.6': [4021, 4183], 'halo-like': [4024], '40Wakabayashi': [4058], 'Hayashi': [4060], 'Kakita': [4062], 'Yamada': [4064], 'Toyoshima': [4066], 'Yoshimoto': [4068, 4127, 4238, 4887, 5457], 'Acta': [4072], '96:': [4075], '445-452Google': [4076], 'Synphilin-1,': [4078], 'interacting': [4084], '(41Engelender': [4086], 'Kaminsky': [4088], 'Guo': [4090], 'X.': [4091], 'Sharp': [4092], 'A.H.': [4093], 'Amaravi': [4094], 'Kleiderlein': [4096], 'J.J.': [4097], 'Margolis': [4098], 'Troncoso': [4100], 'J.C.': [4101], 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