Title: Effect of Exogenous or Endogenous Gastric Inhibitory Polypeptide (GIP) on Plasma Triglyceride Responses in Rats
Abstract: We examined the effects of exogenous and endogenous GIP on plasma triglyceride levels in rats, pretreated with a fat-enriched diet, during intraduodenal infusion of a lipid test meal (Lipomul, 8 ml/h). Following the fat load the plasma triglyceride levels increased nearly linearly from a fasting value of 0.621 ± 0.031 mmol/l to 3.32 ± 0.403 mmol/l at 150 min. Simultaneously, the plasma GIP levels rose from 47.1 ± 5.1 at fasting to a peak value of 268.4 ± 32.2 pmol/l at 120 min. When porcine GIP was infused intravenously during the fat load, the plasma triglyceride increments were significantly smaller (control 1.64 ± 0.264 mmol/l versus 0.949 ± 0.114 mmol/l during GIP infusion at 60 min; p < 0.002). GIP infusion in the absence of the fat load did not change fasting triglyceride levels.
Publication Year: 1991
Publication Date: 1991-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 78
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