Molecular Determinants of Major Histocompatibility Complex Class I Complex Stability

Name: Work Video:
Duration: 3 min 30 s
Daniele Narzi; Kathrin Winkler; Jürgen Saidowsky; Rolf Misselwitz; Andreas Ziegler; Rainer A. Böckmann; Ulrike Alexiev
{'id': 'https://openalex.org/W2035426331', 'doi': 'https://doi.org/10.1074/jbc.m710234200', 'title': 'Molecular Determinants of Major Histocompatibility Complex Class I Complex Stability', 'display_name': 'Molecular Determinants of Major Histocompatibility Complex Class I Complex Stability', 'publication_year': 2008, 'publication_date': '2008-05-28', 'ids': {'openalex': 'https://openalex.org/W2035426331', 'doi': 'https://doi.org/10.1074/jbc.m710234200', 'mag': '2035426331', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18505734'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m710234200', 'pdf_url': 'http://www.jbc.org/article/S0021925819493654/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819493654/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000267232', 'display_name': 'Daniele Narzi', 'orcid': 'https://orcid.org/0000-0003-2731-6286'}, 'institutions': [{'id': 'https://openalex.org/I91712215', 'display_name': 'Saarland University', 'ror': 'https://ror.org/01jdpyv68', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I91712215']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Daniele Narzi', 'raw_affiliation_strings': ['Theoretical and Computational Membrane Biology, Center for Bioinformatics, Universität des Saarlandes, P. O. Box 15 11 50, D-66041 Saarbrücken, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Theoretical and Computational Membrane Biology, Center for Bioinformatics, Universität des Saarlandes, P. O. Box 15 11 50, D-66041 Saarbrücken, Berlin, Germany', 'institution_ids': ['https://openalex.org/I91712215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085262588', 'display_name': 'Kathrin Winkler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I75951250', 'display_name': 'Freie Universität Berlin', 'ror': 'https://ror.org/046ak2485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I75951250']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Kathrin Winkler', 'raw_affiliation_strings': ['the Physics Department, Freie Universität Berlin, Arnimallee 14, D-14195 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'the Physics Department, Freie Universität Berlin, Arnimallee 14, D-14195 Berlin, Germany', 'institution_ids': ['https://openalex.org/I75951250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041584392', 'display_name': 'Jürgen Saidowsky', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I75951250', 'display_name': 'Freie Universität Berlin', 'ror': 'https://ror.org/046ak2485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I75951250']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jürgen Saidowsky', 'raw_affiliation_strings': ['the Physics Department, Freie Universität Berlin, Arnimallee 14, D-14195 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'the Physics Department, Freie Universität Berlin, Arnimallee 14, D-14195 Berlin, Germany', 'institution_ids': ['https://openalex.org/I75951250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015567802', 'display_name': 'Rolf Misselwitz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Rolf Misselwitz', 'raw_affiliation_strings': ['the Institut für Immungenetik, Charité Universitätsmedizin Berlin, Freie Universität zu Berlin, Thielallee 73, D-14195 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'the Institut für Immungenetik, Charité Universitätsmedizin Berlin, Freie Universität zu Berlin, Thielallee 73, D-14195 Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039626163', 'display_name': 'Andreas Ziegler', 'orcid': 'https://orcid.org/0000-0002-8386-5397'}, 'institutions': [{'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Andreas Ziegler', 'raw_affiliation_strings': ['the Institut für Immungenetik, Charité Universitätsmedizin Berlin, Freie Universität zu Berlin, Thielallee 73, D-14195 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'the Institut für Immungenetik, Charité Universitätsmedizin Berlin, Freie Universität zu Berlin, Thielallee 73, D-14195 Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050790406', 'display_name': 'Rainer A. Böckmann', 'orcid': 'https://orcid.org/0000-0002-9325-5162'}, 'institutions': [{'id': 'https://openalex.org/I91712215', 'display_name': 'Saarland University', 'ror': 'https://ror.org/01jdpyv68', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I91712215']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Rainer A. Böckmann', 'raw_affiliation_strings': ['Theoretical and Computational Membrane Biology, Center for Bioinformatics, Universität des Saarlandes, P. O. Box 15 11 50, D-66041 Saarbrücken, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Theoretical and Computational Membrane Biology, Center for Bioinformatics, Universität des Saarlandes, P. O. Box 15 11 50, D-66041 Saarbrücken, Berlin, Germany', 'institution_ids': ['https://openalex.org/I91712215']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077160350', 'display_name': 'Ulrike Alexiev', 'orcid': 'https://orcid.org/0000-0002-2448-0825'}, 'institutions': [{'id': 'https://openalex.org/I75951250', 'display_name': 'Freie Universität Berlin', 'ror': 'https://ror.org/046ak2485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I75951250']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ulrike Alexiev', 'raw_affiliation_strings': ['the Physics Department, Freie Universität Berlin, Arnimallee 14, D-14195 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'the Physics Department, Freie Universität Berlin, Arnimallee 14, D-14195 Berlin, Germany', 'institution_ids': ['https://openalex.org/I75951250']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 4.266, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.895301, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '283', 'issue': '34', 'first_page': '23093', 'last_page': '23103'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10340', 'display_name': 'Hepatitis B Virus Studies', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C207936829', 'wikidata': 'https://www.wikidata.org/wiki/Q423163', 'display_name': 'Major histocompatibility complex', 'level': 3, 'score': 0.68811506}, {'id': 'https://openalex.org/C2777212361', 'wikidata': 'https://www.wikidata.org/wiki/Q5127848', 'display_name': 'Class (philosophy)', 'level': 2, 'score': 0.51585215}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.46520954}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4431551}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.4385391}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19745865}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.18048692}, {'id': 'https://openalex.org/C154945302', 'wikidata': 'https://www.wikidata.org/wiki/Q11660', 'display_name': 'Artificial intelligence', 'level': 1, 'score': 0.09278488}], 'mesh': [{'descriptor_ui': 'D005805', 'descriptor_name': 'Genes, MHC Class I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015796', 'descriptor_name': 'HLA-B27 Antigen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000495', 'descriptor_name': 'Allosteric Site', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001120', 'descriptor_name': 'Arginine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001120', 'descriptor_name': 'Arginine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001224', 'descriptor_name': 'Aspartic Acid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001224', 'descriptor_name': 'Aspartic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015796', 'descriptor_name': 'HLA-B27 Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006863', 'descriptor_name': 'Hydrogen-Ion Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013050', 'descriptor_name': 'Spectrometry, Fluorescence', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D013050', 'descriptor_name': 'Spectrometry, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055672', 'descriptor_name': 'Static Electricity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m710234200', 'pdf_url': 'http://www.jbc.org/article/S0021925819493654/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18505734', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m710234200', 'pdf_url': 'http://www.jbc.org/article/S0021925819493654/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1596708165', 'https://openalex.org/W1899226846', 'https://openalex.org/W1922646908', 'https://openalex.org/W1963813930', 'https://openalex.org/W1968545404', 'https://openalex.org/W1970077833', 'https://openalex.org/W1979391589', 'https://openalex.org/W1981021420', 'https://openalex.org/W1983199450', 'https://openalex.org/W1986152436', 'https://openalex.org/W1990123254', 'https://openalex.org/W1994262866', 'https://openalex.org/W1995138538', 'https://openalex.org/W2003378090', 'https://openalex.org/W2007176915', 'https://openalex.org/W2008271960', 'https://openalex.org/W2021867336', 'https://openalex.org/W2028191700', 'https://openalex.org/W2029501967', 'https://openalex.org/W2034921189', 'https://openalex.org/W2037350993', 'https://openalex.org/W2039172015', 'https://openalex.org/W2046108120', 'https://openalex.org/W2049704184', 'https://openalex.org/W2054881399', 'https://openalex.org/W2057664120', 'https://openalex.org/W2058722206', 'https://openalex.org/W2060952378', 'https://openalex.org/W2062435551', 'https://openalex.org/W2064593553', 'https://openalex.org/W2066224786', 'https://openalex.org/W2070662767', 'https://openalex.org/W2070910664', 'https://openalex.org/W2075369230', 'https://openalex.org/W2076055222', 'https://openalex.org/W2077780092', 'https://openalex.org/W2078933151', 'https://openalex.org/W2087088848', 'https://openalex.org/W2088355124', 'https://openalex.org/W2090443272', 'https://openalex.org/W2094109363', 'https://openalex.org/W2098964986', 'https://openalex.org/W2106319835', 'https://openalex.org/W2109097940', 'https://openalex.org/W2112415662', 'https://openalex.org/W2114788392', 'https://openalex.org/W2123768693', 'https://openalex.org/W2125531202', 'https://openalex.org/W2132717858', 'https://openalex.org/W2143886049', 'https://openalex.org/W2143904486', 'https://openalex.org/W2155450765', 'https://openalex.org/W2162622550', 'https://openalex.org/W2171268876', 'https://openalex.org/W4230821365', 'https://openalex.org/W4285719527', 'https://openalex.org/W4313333783'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W2788277189', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2082860237', 'https://openalex.org/W2046158694', 'https://openalex.org/W2013243191', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418', 'https://openalex.org/W1971568933'], 'abstract_inverted_index': {'A': [0, 247, 978, 3799], 'single': [1, 248, 3095, 3457], 'amino': [2, 249, 942, 1963, 2367, 3485], 'acid': [3, 250, 943], 'exchange': [4, 251, 1767, 2178, 4009], 'between': [5, 66, 252, 313, 927, 1431, 2270, 2294, 2312, 2362, 3349, 3504, 3520], 'the': [6, 18, 42, 81, 96, 100, 147, 165, 172, 193, 243, 253, 265, 289, 328, 343, 347, 394, 412, 419, 440, 490, 568, 631, 647, 883, 891, 1317, 1322, 1365, 1375, 1382, 1388, 1399, 1426, 1522, 1527, 1543, 1618, 1622, 1643, 1652, 1709, 1713, 1722, 1726, 1730, 1733, 1736, 1797, 1805, 1864, 1868, 1872, 1875, 1893, 1961, 1987, 2000, 2166, 2170, 2174, 2177, 2191, 2197, 2201, 2271, 2274, 2295, 2309, 2313, 2317, 2321, 2325, 2352, 2374, 2392, 2395, 2399, 2620, 2626, 2635, 2845, 2850, 2956, 2959, 2966, 2991, 3017, 3020, 3028, 3031, 3086, 3118, 3135, 3154, 3160, 3179, 3200, 3204, 3212, 3218, 3222, 3225, 3232, 3238, 3243, 3248, 3252, 3258, 3261, 3270, 3273, 3307, 3316, 3319, 3327, 3335, 3339, 3345, 3356, 3361, 3374, 3377, 3383, 3391, 3395, 3404, 3434, 3461, 3468, 3487, 3490, 3498, 3501, 3513, 3518, 3521, 3538, 3541, 3583, 3587, 3696, 3739, 3744, 3785, 3790, 3882, 3887, 3892, 3910, 3921, 3925, 3930, 3933, 3965, 3985, 4008, 4025, 4034, 4044, 4048, 4060, 4075, 4132, 4140, 4153, 4158, 4208, 4237, 4252, 4261], 'major': [7, 254, 499, 716, 807], 'histocompatibility': [8, 255, 500, 507, 808], 'complex': [9, 237, 256, 484, 501, 591, 809, 2265, 2285, 2402, 3011, 3264, 3308, 3347, 3544, 3922], 'molecules': [10, 69, 257, 316, 566, 1550, 2212, 2301, 3353, 3471], 'HLA-B*2705': [11, 258, 886], 'and': [12, 34, 51, 74, 95, 130, 134, 152, 169, 184, 225, 230, 239, 259, 281, 298, 321, 342, 377, 381, 399, 416, 431, 472, 477, 486, 571, 611, 894, 930, 988, 1327, 1390, 1433, 1532, 1789, 1801, 1886, 1966, 2088, 2267, 2273, 2276, 2316, 2365, 2623, 2634, 2640, 2855, 2928, 3085, 3129, 3156, 3210, 3230, 3242, 3318, 3351, 3386, 3388, 3413, 3480, 3508, 3525, 3531, 3590, 3635, 3695, 3783, 3800, 3848, 3945, 4150, 4234, 4255, 4277, 4293], 'HLA-B*2709': [13, 260, 931], '(Asp-116/His)': [14, 261, 944], 'is': [15, 206, 262, 453, 602, 628, 639, 708, 890, 920, 1639, 1853, 2403, 3373, 3390, 3545], 'responsible': [16, 263], 'for': [17, 264, 583, 1425, 1542, 1729, 1972, 1984, 2204, 2334, 2477, 3122, 3169, 3247, 3312, 3382, 3433, 3489, 3738, 3784, 4232, 4236, 4251, 4260, 4320], 'emergence': [19, 266], 'of': [20, 30, 85, 116, 164, 190, 196, 223, 233, 242, 267, 277, 332, 363, 411, 437, 443, 470, 480, 489, 496, 540, 593, 630, 649, 652, 850, 924, 980, 1316, 1321, 1368, 1385, 1402, 1428, 1521, 1526, 1545, 1621, 1625, 1654, 1701, 1712, 1716, 1721, 1735, 1768, 1796, 1799, 1874, 1895, 1986, 2003, 2169, 2179, 2196, 2223, 2263, 2398, 2452, 2468, 2571, 2619, 2844, 2849, 2958, 2968, 2994, 3002, 3016, 3023, 3071, 3159, 3203, 3211, 3221, 3224, 3231, 3260, 3306, 3338, 3344, 3376, 3394, 3436, 3440, 3464, 3492, 3500, 3586, 3886, 3891, 3914, 3918, 3929, 3957, 3984, 4010, 4024, 4029, 4037, 4047, 4059, 4139, 4152, 4230, 4247, 4256, 4274, 4282, 4316], 'distinct': [21, 268], 'HLA-B27-restricted': [22, 269], 'T': [23, 270, 578, 732, 2207], 'cell': [24, 271, 569, 579, 2208], 'repertoires': [25, 272], 'in': [26, 126, 137, 141, 156, 171, 181, 273, 373, 384, 388, 403, 418, 428, 940, 1647, 1732, 1783, 1814, 1892, 1999, 2073, 2261, 2284, 2290, 2308, 2372, 2383, 2613, 2925, 2955, 2973, 3019, 3030, 3272, 3363, 3473, 3630, 3794, 3881, 3904, 3920, 4012, 4039, 4050, 4144, 4211], 'individuals': [27, 274], 'harboring': [28, 275], 'either': [29, 276], 'these': [31, 67, 278, 314, 981, 1616], 'two': [32, 105, 279, 352, 1881, 2074, 2296, 3469, 3588, 3795], 'subtypes': [33, 280, 985, 2198, 2621, 3592, 3942], 'could': [35, 282, 3923], 'correlate': [36, 283], 'with': [37, 41, 71, 118, 135, 158, 203, 217, 284, 288, 318, 365, 382, 405, 450, 464, 605, 646, 899, 1627, 1642, 1704, 1765, 1880, 1979, 2336, 2625, 2919, 3132, 3189, 3315, 3329, 3355, 3594, 3743, 3789, 3946, 3961, 4014, 4135, 4207], 'their': [38, 285, 572, 2264, 2915, 3528], 'differential': [39, 286], 'association': [40, 287, 645, 898, 948, 1377, 1635], 'autoimmune': [43, 290, 653], 'disease': [44, 291, 1376], 'ankylosing': [45, 292, 656, 810], 'spondylitis.': [46, 293], 'By': [47, 294], 'using': [48, 295, 986, 2990, 3964, 4062], 'fluorescence': [49, 296, 3201, 3275], 'depolarization': [50, 297], 'pKa': [52, 299, 2478, 3575, 3578, 3733, 3934, 4070], 'calculations,': [53, 300], 'we': [54, 301, 2251, 2341, 3359, 3511], 'investigated': [55, 302, 633, 2382, 3472], 'to': [56, 62, 80, 88, 109, 303, 309, 327, 335, 356, 642, 710, 730, 949, 1364, 1373, 1398, 1636, 1776, 1817, 1976, 2067, 2105, 2165, 2254, 2324, 2985, 3027, 3036, 3134, 3146, 3178, 3411, 3537, 3897, 4032, 4131], 'what': [57, 304], 'extent': [58, 305], 'electrostatic': [59, 221, 306, 468, 2188, 2268], 'interactions': [60, 216, 222, 307, 463, 469, 2269, 2361], 'contribute': [61, 108, 308, 355, 1816], 'shape': [63, 310, 2200], 'antigenic': [64, 240, 311, 487, 712, 2202], 'differences': [65, 312, 2283, 3439], 'HLA': [68, 226, 315, 473, 2300, 3313], 'complexed': [70, 317, 1703, 3354, 3593, 3742, 3788], 'viral,': [72, 319], 'self,': [73, 320], 'non-natural': [75, 322, 843, 846], 'peptide': [76, 101, 111, 121, 178, 224, 323, 348, 358, 368, 425, 471, 520, 821, 825, 831, 1392, 1706, 1723, 1731, 1737, 1787, 1811, 1819, 1851, 1876, 1898, 2001, 2193, 2272, 2291, 2314, 2326, 2344, 2363, 2445, 2637, 3005, 3170, 3321, 3378, 3396, 3698, 3746, 3792, 3916, 3944, 4026], 'ligands.': [77, 324], 'In': [78, 187, 325, 434, 705, 1866, 2061, 2095, 2173], 'addition': [79, 326], 'established': [82, 329], 'main': [83, 330, 1727], 'anchor': [84, 331, 1728], 'peptides': [86, 333, 497, 713, 1656, 1764, 1974, 2075, 2258, 2335, 2381, 2627, 2911, 3029, 3523, 3597, 3838, 3901], 'binding': [87, 179, 334, 426, 1393, 1738, 1803, 1820, 1877, 1975, 2071, 2098, 2194, 2292, 2318, 2327, 2345, 2375, 3463], 'HLA-B27,': [89, 336, 2224], 'arginine': [90, 119, 337, 366, 1717, 2079], 'at': [91, 99, 103, 120, 338, 346, 350, 367, 567, 1718, 1871, 2080, 3080, 3257], 'position': [92, 122, 339, 369, 1719, 1812, 2081, 2926], '2': [93, 340, 1720, 3177], '(pArg-2),': [94, 341], 'secondary': [97, 344, 1859], 'anchors': [98, 345, 1971, 2315], 'termini,': [102, 349], 'least': [104, 351, 3185], 'further': [106, 353], 'determinants': [107, 354], 'stable': [110, 357, 1818, 2167], 'accommodation.': [112, 359], '1)': [113, 360, 2260, 3149], 'The': [114, 161, 219, 361, 408, 466, 494, 586, 621, 1697, 1847, 2279, 2386, 2909, 3140, 3732, 3837, 3884, 3900, 4069, 4181], 'interaction': [115, 194, 362, 441, 1894, 2310, 4263], 'Asp-116': [117, 364, 1870, 2063, 2106, 2180], '5,': [123, 370], 'as': [124, 139, 201, 371, 386, 448, 720, 1198, 1200, 1395, 1658, 1725, 1770, 1855, 2214, 2287, 2289, 2644, 2912, 2914, 3153, 3163, 3165, 3533, 3556, 3954], 'found': [125, 140, 372, 387], 'pLMP2': [127, 374, 3526, 4013, 4040], '(RRRWRRLTV;': [128, 375], 'viral)': [129, 376], 'pVIPR': [131, 378, 3524, 3629, 3958, 4051], '(RRKWRRWHL;': [132, 379], 'self),': [133, 380], 'lysine': [136, 383], 'pΩ,': [138, 385], 'gag': [142, 389], '(KRWIILGLNK;': [143, 390], 'viral),': [144, 391], 'additionally': [145, 392, 3937], 'stabilizes': [146, 393], 'B*2705': [148, 395, 938, 1638, 1702, 1867, 1989, 2275, 2622, 3350, 3385, 3589, 3786], 'complexes': [149, 396, 2947, 2972, 3314, 3384, 3893], 'by': [150, 198, 208, 214, 397, 445, 455, 461, 498, 574, 1436, 1779, 2181, 2206, 2306, 2351, 2358, 3014, 3116, 3174, 3269, 3368, 3402, 3452, 3483, 3547, 4043, 4054, 4078, 4291], '∼5': [151, 398], '∼27': [153, 400], 'kJ/mol,': [154, 401], 'respectively,': [155, 402, 2930, 3510], 'comparison': [157, 404, 979, 3343, 3499], 'B*2709.': [159, 406], '2)': [160, 407, 3188], 'protonation': [162, 189, 232, 409, 436, 479, 3927, 4146], 'state': [163, 410, 3088, 3181, 3206, 3928], 'key': [166, 234, 413, 481, 1397, 1890], 'residues': [167, 414, 515, 818, 1899, 2364, 2411, 4030], 'Glu-45': [168, 415], 'Glu-63': [170, 417], 'B-pocket,': [173, 420], 'which': [174, 421, 638, 935, 1861, 2162, 4126], 'accommodates': [175, 422], 'pArg-2,': [176, 423, 1769], 'affects': [177, 424], 'strength': [180, 427, 4273], 'a': [182, 209, 429, 456, 594, 606, 612, 650, 896, 1396, 1794, 1856, 1889, 2069, 2085, 2091, 2102, 2614, 3008, 3093, 3184, 3431, 3456, 3465, 3534, 3548, 3557, 3915, 3962, 4015, 4017, 4055, 4063, 4136, 4227, 4240, 4244, 4265, 4278, 4311], 'peptide-': [183, 229, 430, 476], 'subtype-dependent': [185, 231, 432, 478], 'manner.': [186, 433], 'B*2705/pLMP2,': [188, 435], 'Glu-45/Glu-63': [191, 211, 438, 458], 'reduces': [192, 439], 'energy': [195, 442, 2311, 2329, 3365, 3438, 4057, 4254], 'pArg-2': [197, 444, 1800], '∼24': [199, 446], 'kJ/mol': [200, 447], 'compared': [202, 449], 'B*2705/pVIPR.': [204, 451], 'B*2705/pVIPR': [205, 452], 'stabilized': [207, 454], 'deprotonated': [210, 457], 'pair,': [212, 459], 'evoked': [213, 460], 'allosteric': [215, 462], 'pHis-8.': [218, 465], 'mutual': [220, 467], 'molecule,': [227, 474], 'including': [228, 475, 655], 'residues,': [235, 482, 1884], 'modulate': [236, 483], 'stability': [238, 485, 1788, 2266, 2286, 3348, 3503], 'features': [241, 488, 2203], 'respective': [244, 491, 2171, 2960, 3340], 'HLA-B27': [245, 492, 627, 707, 884, 1403, 1437, 1626, 1780, 1790, 3263, 3470, 3941], 'subtype.': [246, 493], 'presentation': [495, 1653], '(MHC)': [502], '4The': [503], 'abbreviations': [504], 'used': [505, 2476, 3512, 3888, 4210], 'are:MHCmajor': [506], 'complexASankylosing': [508], 'spondylitispLMP2Epstein-Barr': [509], 'virus': [510, 552, 728, 813, 865, 880, 2460, 2471, 2481], 'latent': [511, 814, 2461], 'membrane': [512, 815, 2462], 'protein': [513, 816, 2463, 4238], '2,': [514, 817, 2464], '236–244': [516, 819], '(RRRWRRLTV)pLMP2-T8Hpeptide': [517], 'RRRWRRLHVpVIPRvasoactive': [518], 'intestinal': [519, 824, 2444], 'type': [521, 826, 2446], '1': [522, 827, 2447], 'receptor,': [523, 828, 2448, 2456], '400–408': [524, 829], '(RRKWRRWHL)pVIPR-H8Tpeptide': [525], 'RRKWRRWTLpGRglucagon': [526], 'receptor': [527, 834, 872], '412–420': [528, 835], '(RRRWHRWRL)TISepidermal': [529], 'growth': [530, 838, 2407], 'factor-response': [531, 839], 'factor,': [532, 840, 2410], '479–487': [533, 841], '(RRLPIFSRL)m9non-natural': [534], 'ligand': [535, 537, 844, 847, 2568], '(GRFAAAIAK)S10Rnon-natural': [536], '(artificial': [538, 848, 2569], 'mutant': [539, 849, 2451, 2467, 2475, 2570], 'B*2707': [541, 851, 2572], 'HC': [542, 852, 2366, 2573], '110–119)': [543, 853], '(RRLLRGHNQY)gagviral': [544], 'HIV-p24': [545, 856, 2508], 'gag,': [546, 857, 2509, 2632], '263–272': [547, 858], '(KRWIILGLNK)fluinfluenza': [548], 'nucleoprotein,': [549, 861, 2482], '383–391': [550, 862, 3850], '(SRYWAIRTR)pEBNA-3CEpstein-Barr': [551], 'EBNA3C,': [553, 866, 2472], '258–266': [554, 867], '(RRIYDLIEL)KIR3DL1natural': [555], 'killer': [556, 870, 2219], 'Ig-like': [557, 871], 'receptorLYIALucifer': [558], 'Yellow': [559, 874, 2921, 2996, 3077, 3331], 'iodoacetamideHCheavy': [560], 'chainHIVhuman': [561], 'immunodeficiency': [562, 727, 879], 'virusβ2mβ2-microglobulin.': [563], 'class': [564, 589, 624, 635], 'I': [565, 590, 625, 636], 'surface': [570, 4279], 'recognition': [573, 2205], 'cellular': [575], 'ligands': [576], 'like': [577, 3455], 'receptors': [580, 2209, 2216], 'are': [581, 1792, 1968, 1993, 2347, 2370, 3476, 3495, 3902], 'fundamental': [582], 'immune': [584, 1784], 'responses.': [585], 'trimeric': [587], 'MHC': [588, 623, 634], 'consists': [592], 'highly': [595, 2969], 'polymorphic': [596], 'transmembrane': [597], 'heavy': [598, 876, 1569], 'chain': [599, 877, 1570, 4036, 4046], '(HC)': [600], 'that': [601, 1960, 2076, 2282, 2343, 2369, 3326, 3449], 'noncovalently': [603], 'associated': [604], 'light': [607], 'chain,': [608], 'β2-microglobulin': [609], '(β2m)': [610], 'peptidic': [613], 'fragment': [614], 'derived': [615, 714], 'from': [616, 715, 937, 1633, 1661, 2084, 2090, 2933, 2951, 3007, 3034, 3399, 3841, 3845, 3852, 3895, 4157], 'self': [617], 'or': [618, 725, 1547, 1593, 1981, 1996, 2210, 2378, 2941, 3214, 3234, 3460, 3527, 3912, 3947], 'non-self': [619], 'proteins.': [620], 'human': [622, 726, 878], 'antigen': [626], 'one': [629, 941, 3484], 'best': [632], 'molecules,': [637], 'partly': [640], 'due': [641], 'its': [643, 1391, 1634, 1802], 'strong': [644, 1623, 1969, 2187], 'development': [648], 'variety': [651], 'diseases,': [654], 'spondylitis': [657, 811], '(AS)': [658], '(1Allen': [659], 'R.': [660, 679, 737, 781, 906, 964, 966, 996, 1000, 1015, 1051, 1070, 1078, 1112, 1141, 1171, 1179, 1205, 1213, 1247, 1272, 1302, 1409, 1445, 1475, 1483, 1507, 1552, 1666, 1668, 1903, 2114, 2139, 2420, 2539, 2576, 2584, 2650, 2686, 2711, 2740, 2770, 2778, 2800, 2830, 3042, 3280, 3606, 3647, 3673, 3703, 3748, 3756, 3810, 3818, 3993, 4165], 'Bowness': [661, 1574, 1751, 1943, 2238, 2495, 2522, 3865], 'P.': [662, 756, 758, 962, 1575, 1664, 1676, 1752, 1944, 2239, 2496, 2523, 3866], 'McMichael': [663, 763, 794, 1683, 1747, 1939, 2234, 2491, 2518, 3861], 'A.': [664, 743, 764, 795, 904, 958, 960, 1017, 1025, 1055, 1084, 1088, 1122, 1145, 1177, 1219, 1223, 1257, 1278, 1310, 1312, 1338, 1407, 1449, 1481, 1515, 1517, 1599, 1682, 1684, 1748, 1830, 1905, 1913, 1940, 2014, 2034, 2038, 2118, 2143, 2235, 2430, 2492, 2519, 2541, 2549, 2590, 2594, 2652, 2660, 2690, 2721, 2744, 2776, 2806, 2838, 2840, 2866, 2900, 3048, 3286, 3610, 3651, 3683, 3705, 3713, 3762, 3766, 3816, 3862], 'Immunogenetics.': [665], '1999;': [666], '50:': [667], '220-227Crossref': [668], 'PubMed': [669, 686, 700, 750, 771, 802, 914, 973, 1007, 1039, 1064, 1100, 1129, 1159, 1193, 1235, 1264, 1292, 1355, 1417, 1463, 1497, 1564, 1588, 1610, 1692, 1759, 1842, 1927, 1951, 2026, 2056, 2127, 2157, 2246, 2437, 2503, 2530, 2563, 2606, 2674, 2699, 2728, 2758, 2792, 2820, 2883, 2904, 3062, 3111, 3300, 3423, 3570, 3624, 3660, 3690, 3727, 3778, 3832, 3873, 3976, 4002, 4093, 4107, 4121, 4222, 4306], 'Scopus': [670, 687, 701, 751, 772, 803, 915, 974, 1008, 1040, 1065, 1101, 1130, 1160, 1194, 1236, 1265, 1293, 1356, 1418, 1464, 1498, 1565, 1589, 1611, 1693, 1760, 1843, 1928, 1952, 2027, 2057, 2128, 2158, 2247, 2438, 2504, 2531, 2564, 2607, 2675, 2700, 2729, 2759, 2793, 2821, 2884, 2905, 3063, 3112, 3301, 3424, 3571, 3625, 3661, 3691, 3728, 3779, 3833, 3874, 3977, 4003, 4094, 4108, 4122, 4177, 4203, 4223, 4307], '(69)': [671], 'Google': [672, 689, 703, 753, 774, 805, 917, 976, 1010, 1042, 1067, 1103, 1132, 1162, 1196, 1238, 1267, 1295, 1358, 1420, 1466, 1500, 1567, 1591, 1613, 1695, 1762, 1845, 1930, 1954, 2029, 2059, 2130, 2160, 2249, 2440, 2506, 2533, 2566, 2609, 2677, 2702, 2731, 2761, 2795, 2823, 2886, 2907, 3065, 3114, 3303, 3426, 3573, 3627, 3663, 3693, 3730, 3781, 3835, 3876, 3979, 4005, 4096, 4110, 4124, 4179, 4205, 4225, 4309], 'Scholar,': [673, 690, 754, 775, 1011, 1043, 1068, 1104, 1133, 1163, 1239, 1268, 1296, 1334, 1467, 1501, 1931, 2030, 2131, 2678, 2703, 2732, 2762, 2796, 2824, 2862, 2887, 4097, 4111], '2Kim': [674], 'T.-H.': [675], 'Uhm': [676], 'W.-S.': [677], 'Inman': [678], 'Curr.': [680], 'Opin.': [681], 'Rheumatol.': [682], '2005;': [683, 1126, 1151, 1261, 1455, 1756, 1948, 2149, 2243, 2434, 2500, 2527, 2725, 2750, 3616, 3687, 3870], '17:': [684], '400-405Crossref': [685], '(82)': [688], '3Lopez': [691], 'de': [692, 1822, 2006, 2042], 'Castro': [693, 1823, 2007, 2043], 'J.A.': [694, 1314, 1519, 2842], 'Immunol.': [695, 767, 969, 1578, 1601, 1755, 1947, 2242, 2499, 2526, 3869], 'Lett.': [696], '2007;': [697, 911, 1347, 1414, 2875], '108:': [698], '27-33Crossref': [699], '(63)': [702], 'Scholar).': [704, 806, 918, 977, 1421, 1614, 1696, 1846, 1955, 2060, 2908, 3066, 3304, 3574, 4180], 'addition,': [706, 2062], 'known': [709], 'present': [711], 'infectious': [717], 'agents,': [718], 'such': [719, 1657, 2213, 3152], 'Epstein-Barr': [721, 812, 864, 2459, 2470, 3846], 'virus,': [722, 724, 3847], 'influenza': [723, 860, 2480, 3853], '(HIV)': [729], 'cytotoxic': [731], 'lymphocytes': [733], '(4Brooks': [734], 'J.': [735, 744, 762, 766, 777, 787, 793, 968, 1001, 1028, 1058, 1089, 1123, 1148, 1173, 1182, 1224, 1258, 1281, 1346, 1452, 1477, 1486, 1573, 1577, 1754, 1824, 1916, 1946, 2008, 2040, 2044, 2045, 2121, 2146, 2241, 2431, 2498, 2525, 2552, 2595, 2663, 2693, 2722, 2747, 2772, 2781, 2809, 2874, 3051, 3105, 3289, 3418, 3565, 3613, 3654, 3684, 3716, 3767, 3812, 3821, 3868, 3970, 4099, 4101, 4113, 4115, 4167, 4170, 4196, 4214, 4216], 'Murray': [736], 'Thomas': [738], 'W.': [739, 789, 1021, 1023, 1053, 1074, 1118, 1143, 1175, 1209, 1253, 1308, 1447, 1479, 1513, 1909, 1911, 2116, 2141, 2426, 2545, 2547, 2580, 2656, 2658, 2688, 2717, 2742, 2774, 2836, 3416, 3563, 3608, 3649, 3679, 3709, 3711, 3752, 3814, 4169, 4191], 'Kurilla': [740], 'M.': [741, 952, 954, 992, 994, 998, 1013, 1019, 1045, 1047, 1072, 1106, 1135, 1139, 1167, 1207, 1241, 1304, 1439, 1443, 1471, 1509, 1674, 1828, 1832, 1836, 1901, 1907, 2012, 2016, 2020, 2032, 2036, 2108, 2110, 2133, 2137, 2414, 2537, 2543, 2578, 2648, 2654, 2680, 2682, 2705, 2734, 2738, 2766, 2832, 3600, 3604, 3641, 3643, 3667, 3701, 3707, 3750, 3806], 'Rickinson': [742], 'Exp.': [745, 1059, 2122, 2694, 3655], 'Med.': [746, 1060, 1554, 1688, 2123, 2695, 3656], '1993;': [747, 768], '178:': [748], '879-887Crossref': [749], '(94)': [752], '5Bowness': [755], 'Moss': [757], 'Rowland-Jones': [759, 796, 1685], 'S.': [760, 785, 797, 1670, 1686, 1746, 1938, 2233, 2490, 2517, 2899, 3860], 'Bell': [761], 'Eur.': [765, 967, 1753, 1945, 2240, 2497, 2524, 3867], '23:': [769, 4000], '1417-1421Crossref': [770], '(99)': [773], '6Wilson': [776], 'Ogg': [778, 1671], 'G.': [779, 1672, 1678, 1741, 1933, 2228, 2485, 2512, 3855, 3969, 3989, 3991, 3997, 4085, 4163, 4298], 'Allen': [780], 'Davis': [782], 'C.': [783, 791, 956, 1082, 1137, 1165, 1217, 1340, 1441, 1469, 2135, 2588, 2736, 2764, 2868, 3602, 3760, 3804, 3995], 'Shaunak': [784], 'Downie': [786], 'Dyer': [788], 'Workman': [790], 'Sullivan': [792], 'AIDS.': [798], '2000;': [799, 1004, 1556, 1580], '14:': [800], '225-233Crossref': [801], '(136)': [804, 4123], '(RRRWRRLTV)': [820], 'RRRWRRLHV': [822], 'vasoactive': [823, 2443], '(RRKWRRWHL)': [830], 'RRKWRRWTL': [832], 'glucagon': [833, 2455], '(RRRWHRWRL)': [836], 'epidermal': [837, 2406], '(RRLPIFSRL)': [842], '(GRFAAAIAK)': [845], '(RRLLRGHNQY)': [854], 'viral': [855, 2092], '(KRWIILGLNK)': [859, 1660], '(SRYWAIRTR)': [863], '(RRIYDLIEL)': [868], 'natural': [869, 1988, 2218, 3317], 'Lucifer': [873, 2920, 2995, 3076, 3330], 'iodoacetamide': [875], 'β2-microglobulin.': [881], 'Among': [882], 'subtypes,': [885], '(in': [887, 932, 2221], 'short,': [888, 933], 'B*2705)': [889], 'most': [892, 1384], 'common': [893], 'exhibits': [895], 'clear-cut': [897], 'AS': [900, 950], '(7Khan': [901, 1404], 'M.A.': [902, 1405], 'Mathieu': [903, 957, 1406], 'Sorrentino': [905, 965, 999, 1050, 1140, 1178, 1408, 1444, 1482, 2113, 2138, 2685, 2739, 2777, 3605, 3646, 3817], 'Akkoc': [907, 1410], 'N.': [908, 1411], 'Autoimmun.': [909, 1412], 'Rev.': [910, 1413], '6:': [912, 1415, 1557], '183-189Crossref': [913, 1416], '(115)': [916, 1419], 'There': [919], 'an': [921, 1766, 2078, 4271], 'increasing': [922], 'number': [923], 'comparative': [925], 'studies': [926, 990, 1958], 'this': [928, 1705, 2096, 2186, 2384, 3474], 'subtype': [929, 3741, 3787], 'B*2709),': [934], 'differs': [936], 'only': [939, 2350, 3444, 3451, 3482], 'but': [945, 1540, 2356], 'shows': [946], 'no': [947], "(8D'Amato": [951], 'Fiorillo': [953, 1046, 1166, 1470, 2109, 2681, 2765, 3642, 3805], 'Carcassi': [955], 'Zuccarelli': [959], 'Bitti': [961], 'Tosi': [963], '1995;': [970, 3999], '25:': [971], '3199-3201Crossref': [972], '(185)': [975, 4095, 4308], 'very': [982, 2297, 3477], 'closely': [983, 2298, 3478], 'related': [984, 2299, 3479], 'functional': [987], 'structural': [989], '(9Fiorillo': [991], 'Maragno': [993], 'Butler': [995], 'Dupuis': [997], 'Clin.': [1002], 'Investig.': [1003], '106:': [1005], '47-53Crossref': [1006], '(159)': [1009], '10Hülsmeyer': [1012], 'Hillig': [1014, 1301, 1506, 1902, 2538, 2649, 2829, 3702], 'Volz': [1016, 1083, 1218, 1309, 1514, 1904, 2540, 2589, 2651, 2837, 3704, 3761], 'Rühl': [1018, 1906, 2542, 2653, 3706], 'Schröder': [1020, 1908, 2544, 2655, 3708], 'Saenger': [1022, 1052, 1073, 1117, 1142, 1174, 1208, 1252, 1307, 1446, 1478, 1512, 1910, 2115, 2140, 2425, 2546, 2579, 2657, 2687, 2716, 2741, 2773, 2835, 3607, 3648, 3678, 3710, 3751, 3813], 'Ziegler': [1024, 1054, 1087, 1121, 1144, 1176, 1222, 1256, 1277, 1311, 1448, 1480, 1516, 1598, 1912, 2117, 2142, 2429, 2548, 2593, 2659, 2689, 2720, 2743, 2775, 2805, 2839, 3047, 3285, 3609, 3650, 3682, 3712, 3765, 3815], 'Uchanska-Ziegler': [1026, 1056, 1085, 1119, 1146, 1180, 1220, 1254, 1275, 1341, 1450, 1484, 1914, 2119, 2144, 2427, 2550, 2591, 2661, 2691, 2718, 2745, 2779, 2803, 2869, 3045, 3283, 3611, 3652, 3680, 3714, 3763, 3819], 'B.': [1027, 1057, 1086, 1120, 1147, 1169, 1181, 1221, 1255, 1276, 1298, 1342, 1451, 1473, 1485, 1503, 1597, 1680, 1915, 2120, 2145, 2428, 2551, 2592, 2662, 2692, 2719, 2746, 2768, 2780, 2804, 2826, 2870, 3046, 3284, 3612, 3653, 3681, 3715, 3764, 3808, 3820, 4173, 4195, 4199], 'Biol.': [1029, 1090, 1125, 1149, 1183, 1225, 1260, 1282, 1453, 1487, 1917, 2046, 2147, 2433, 2553, 2596, 2664, 2724, 2748, 2782, 2810, 3052, 3107, 3290, 3614, 3686, 3717, 3768, 3822], 'Chem.': [1030, 1091, 1150, 1184, 1226, 1283, 1454, 1488, 1918, 2047, 2148, 2554, 2597, 2665, 2749, 2783, 2811, 3053, 3291, 3615, 3718, 3769, 3823, 4172, 4198], '2002;': [1031, 1919, 2048, 2555, 2666, 3719], '277:': [1032, 1920, 2049, 2556, 2667, 3720], '47844-47853Abstract': [1033, 1921, 2557, 2668, 3721], 'Full': [1034, 1036, 1095, 1097, 1154, 1156, 1188, 1190, 1230, 1232, 1287, 1289, 1350, 1352, 1458, 1460, 1492, 1494, 1559, 1561, 1583, 1585, 1605, 1607, 1922, 1924, 2051, 2053, 2152, 2154, 2558, 2560, 2601, 2603, 2669, 2671, 2753, 2755, 2787, 2789, 2815, 2817, 2878, 2880, 3057, 3059, 3295, 3297, 3619, 3621, 3722, 3724, 3773, 3775, 3827, 3829], 'Text': [1035, 1037, 1096, 1098, 1155, 1157, 1189, 1191, 1231, 1233, 1288, 1290, 1351, 1353, 1459, 1461, 1493, 1495, 1560, 1562, 1584, 1586, 1606, 1608, 1923, 1925, 2052, 2054, 2153, 2155, 2559, 2561, 2602, 2604, 2670, 2672, 2754, 2756, 2788, 2790, 2816, 2818, 2879, 2881, 3058, 3060, 3296, 3298, 3620, 3622, 3723, 3725, 3774, 3776, 3828, 3830], 'PDF': [1038, 1099, 1158, 1192, 1234, 1291, 1354, 1462, 1496, 1563, 1587, 1609, 1926, 2055, 2156, 2562, 2605, 2673, 2757, 2791, 2819, 2882, 3061, 3299, 3623, 3726, 3777, 3831], '(80)': [1041, 1929, 2565, 2676, 3729], '11Hülsmeyer': [1044, 2679], 'Bettosini': [1048, 2111, 2683, 3644], 'F.': [1049, 2112, 2684, 3645], '2004;': [1061, 1092, 1227, 1284, 1839, 2023, 2124, 2598, 2696, 2812, 3054, 3292, 3657, 3770], '199:': [1062, 2125, 2697, 3658], '271-281Crossref': [1063, 2126, 2698, 3659], '(135)': [1066, 2129, 2701, 3662], '12Hillig': [1069], 'Hülsmeyer': [1071, 1138, 1206, 1303, 1442, 1508, 2136, 2577, 2737, 2831, 3603, 3749], 'Welfle': [1075, 1079, 1107, 1115, 1210, 1214, 1242, 1250, 2415, 2423, 2581, 2585, 2706, 2714, 3668, 3676, 3753, 3757], 'K.': [1076, 1108, 1211, 1243, 1336, 1744, 1936, 2231, 2416, 2488, 2515, 2582, 2707, 2864, 3669, 3754, 3858], 'Misselwitz': [1077, 1111, 1212, 1246, 2419, 2583, 2710, 3672, 3755], 'H.': [1080, 1116, 1215, 1251, 1274, 2424, 2586, 2715, 2802, 3044, 3282, 3677, 3758], 'Kozerski': [1081, 1216, 2587, 3759], '279:': [1093, 1228, 1285, 2599, 2813, 3055, 3293, 3771], '652-663Abstract': [1094, 1229, 2600, 3772], '(58)': [1102, 1237, 2608, 3780], '13Hülsmeyer': [1105, 1240, 2704], 'Pöhlmann': [1109, 1244, 1305, 1510, 2417, 2708, 2833, 3103, 3670], 'T.': [1110, 1245, 1270, 1306, 1511, 2418, 2709, 2798, 2834, 3040, 3104, 3278, 3671], 'Alexiev': [1113, 1248, 1279, 1299, 1343, 1504, 2421, 2712, 2807, 2827, 2871, 3049, 3287, 3674], 'U.': [1114, 1249, 1280, 1300, 1344, 1505, 2422, 2713, 2808, 2828, 2872, 2898, 3050, 3100, 3288, 3675], 'Mol.': [1124, 1259, 1553, 2432, 2723, 3106, 3685, 3971], '346:': [1127, 1262, 2435, 2726, 3688], '1367-1379Crossref': [1128, 1263, 2436, 2727, 3689], '(46)': [1131, 1266, 2439, 2730, 3692], '14Fiorillo': [1134, 2132, 2733], 'Rückert': [1136, 1339, 1440, 2134, 2735, 2867, 3601], '280:': [1152, 1456, 2150, 2751, 3617], '2962-2971Abstract': [1153, 1457, 2151, 2752, 3618], '(76)': [1161, 1465, 2159, 2760, 3113, 3626], '15Rückert': [1164, 1468, 2763], 'Loll': [1168, 1472, 2767, 3807], 'Moretti': [1170, 1474, 2769, 3809], 'Biesiadka': [1172, 1476, 2771, 3811], '2006;': [1185, 1489, 2784, 3824], '281:': [1186, 1490, 2785, 3825], '2306-2316Abstract': [1187, 1491, 2786, 3826], '(44)': [1195, 1499, 2794, 3834], 'Scholar)': [1197, 1359, 2610, 3115, 3782, 3877, 3980], 'well': [1199, 2288, 2913, 3164], 'various': [1201], 'biophysical': [1202], 'methods': [1203], '(12Hillig': [1204, 2575, 3747], '16Pöhlmann': [1269, 2797], 'Böckmann': [1271, 2799, 3041, 3279], 'Grubmüller': [1273, 2801, 3043, 3281], '28197-28201Abstract': [1286, 2814, 3056, 3294], '(75)': [1294, 2822, 3064, 3302], '17Uchanska-Ziegler': [1297, 1502, 2825], 'Hansen': [1313, 1518, 2841], 'Immunobiology': [1315, 1520, 2843], 'Human': [1318, 1523, 2846], 'MHC:': [1319, 1524, 2847], 'Proceedings': [1320, 1525, 2848], '13th': [1323, 1528, 2851], 'International': [1324, 1529, 2852], 'Histocompatibility': [1325, 1530, 2853], 'Workshop': [1326, 1531, 2854], 'Congress.': [1328, 1533, 2856], '1.': [1329, 1534, 2857, 3906], 'IHWG': [1330, 1535, 2858], 'Press,': [1331, 1536, 2859], 'Seattle2006:': [1332, 1537, 2860], '138-147Google': [1333, 1538, 2861], '18Winkler': [1335, 2863], 'Winter': [1337, 2865], 'Biophys.': [1345, 2873], '93:': [1348, 2876], '2743-2755Abstract': [1349, 2877], '(30)': [1357, 2885], 'may': [1360, 1813], 'eventually': [1361], 'provide': [1362], 'clues': [1363], 'pathogenic': [1366, 1400], 'role': [1367, 1401, 1711, 1891], 'HLA-B27.': [1369], 'Several': [1370], 'theories': [1371], 'seeking': [1372], 'explain': [1374], 'have': [1378, 4285], 'been': [1379, 2065, 4286], 'published': [1380], 'over': [1381], 'years,': [1383], 'them': [1386], 'regarding': [1387], 'molecule': [1389], 'properties': [1394, 2195, 3337], 'This': [1422, 3193], 'holds': [1423], 'true': [1424], 'hypotheses': [1427], 'molecular': [1429, 1619], 'mimicry': [1430], 'foreign': [1432], 'self-peptides': [1434], 'presented': [1435, 1778, 3793], '(14Fiorillo': [1438, 3599], 'Scholar),': [1539, 1568, 1592, 2161, 2250, 3427, 3628, 3664, 3694, 4125, 4206, 4310], 'also': [1541, 1640, 2199, 2357, 3267, 3736, 3879], 'involvement': [1544], 'misfolded': [1546], 'partially': [1548, 4321], 'unfolded': [1549, 3213, 3233], '(19Colbert': [1551], 'Today.': [1555, 1579], '224-230Abstract': [1558], '(105)': [1566, 4109, 4224], 'homodimers': [1571], '(20Edwards': [1572], 'Archer': [1576], '21:': [1581], '256-260Abstract': [1582], '(57)': [1590], 'liberated': [1594], 'β2m': [1595, 3919], '(21Uchanska-Ziegler': [1596], 'Trends': [1600], '2003;': [1602, 3108, 4104, 4118, 4219], '24:': [1603], '73-76Abstract': [1604], '(42)': [1612], 'Despite': [1615], 'efforts,': [1617], 'basis': [1620], 'linkage': [1624], 'spondyloarthropathies': [1628], 'still': [1629], 'remains': [1630], 'elusive.': [1631], 'Apart': [1632], 'spondyloarthropathies,': [1637], 'connected': [1641], 'long': [1644, 2359], 'term': [1645], 'nonprogression': [1646], 'chronic': [1648], 'HIV': [1649, 1662, 1773], 'infection': [1650], 'through': [1651], 'B*2705-restricted': [1655], 'gag-(263–272)': [1659, 3839], '(22Goulder': [1663], 'Phillips': [1665], 'Colbert': [1667], 'McAdam': [1669], 'Nowak': [1673], 'Giangrande': [1675], 'Luzzi': [1677], 'Morgana': [1679], 'Edwards': [1681], 'Nat.': [1687], '1997;': [1689], '3:': [1690], '212-217Crossref': [1691], '(1018)': [1694], 'recent': [1698], 'crystal': [1699, 2396, 3584, 3889], 'structure': [1700, 2397, 4061], 'demonstrates': [1707], 'again': [1708], 'pivotal': [1710], 'guanidinium': [1714], 'group': [1715], '(pArg-2)': [1724], 'B-pocket': [1734, 1806], 'groove': [1739], '(23Stewart-Jones': [1740, 2227, 2484, 2511, 3854], 'di': [1742, 1934, 2229, 2486, 2513, 3856], 'Gleria': [1743, 1935, 2230, 2487, 2514, 3857], 'Kollnberger': [1745, 1937, 2232, 2489, 2516, 3859], 'Jones': [1749, 1941, 2236, 2493, 2520, 3863], 'E.': [1750, 1942, 2237, 2494, 2521, 3864, 4193], '35:': [1757, 1949, 2244, 2501, 2528, 3871], '341-351Crossref': [1758, 1950, 2245, 2502, 2529, 3872], '(90)': [1761, 1953, 2248, 2505, 2532, 3875], 'Scholar);': [1763], 'observed': [1771], 'during': [1772], 'infections,': [1774], 'fail': [1775], 'be': [1777, 2304], 'antigens': [1781], 'resulting': [1782], 'escape.': [1785], 'Although': [1786], 'selectivity': [1791], 'mainly': [1793, 2303], 'consequence': [1795], 'presence': [1798, 2957, 3911], 'within': [1804, 1863, 3092], '(Fig.': [1807], '1),': [1808], 'every': [1809], 'other': [1810, 1882, 2211], 'principle': [1815], '(24López': [1821, 2005], 'Alvarez': [1825, 2009], 'I.': [1826, 2010, 3102], 'Marcilla': [1827, 2011], 'Paradela': [1829, 2013, 2033], 'Ramos': [1831, 2015], 'Sesma': [1833, 2017], 'L.': [1834, 2018], 'Vázquez': [1835, 2019, 2035, 2039], 'Tissue': [1837, 2021], 'Antigens.': [1838, 2022], '63:': [1840, 2024], '424-445Crossref': [1841, 2025], '(85)': [1844, 2028], 'C': [1848], 'terminal': [1849], '(pΩ)': [1850], 'residue': [1852, 3577], 'regarded': [1854], 'particularly': [1857], 'important': [1858], 'anchor,': [1860], 'binds': [1862], 'F-pocket.': [1865], 'acidic': [1869], 'floor': [1873], 'groove,': [1878, 2319], 'along': [1879], 'F-pocket': [1883], 'Asp-74': [1885], 'Asp-77,': [1887], 'plays': [1888], 'basic': [1896, 1962], 'pΩ': [1897, 1970], '(10Hülsmeyer': [1900, 2536, 2647, 3700], '23Stewart-Jones': [1932], 'Peptide': [1956, 3003, 3950], 'elution': [1957], 'showed': [1959], 'acids': [1964, 2368], 'Lys': [1965], 'Arg': [1967], 'nonameric': [1973], 'B*2705.': [1977], 'Peptides': [1978], 'pΩArg': [1980], 'pΩLys': [1982], 'account': [1983], '27%': [1985], 'ligands,': [1990], 'whereas': [1991], 'they': [1992], 'absent': [1994], '(pΩLys)': [1995], 'rare': [1997], '(pΩArg)': [1998], 'repertoire': [2002], 'B*2709': [2004, 2175, 2277, 2379, 2624, 3352, 3387, 3400, 3591, 3740], '25Ramos': [2031], 'Marina': [2037], 'López': [2041], '28749-28756Abstract': [2050], '(79)': [2058], 'has': [2064], 'reported': [2066], 'promote': [2068], 'noncanonical': [2070, 2097, 3636], 'mode': [2072], 'contain': [2077], '5': [2082, 3035], '(RRKWRRWHL': [2083], 'self-protein,': [2086], 'pVIPR;': [2087], 'RRRWRRLTV': [2089], 'protein,': [2093], 'pLMP2).': [2094], 'mode,': [2099], 'pArg-5': [2100], 'forms': [2101], 'salt': [2103], 'bridge': [2104], '(11Hülsmeyer': [2107, 3640], 'presumably': [2163], 'adds': [2164], 'accommodation': [2168], 'peptide.': [2172, 2961], 'subtype,': [2176], 'His': [2182], 'does': [2183, 3332], 'not': [2184, 2349, 3323, 3333], 'permit': [2185], 'interaction.': [2189], 'As': [2190, 3540, 4288], 'different': [2192, 2257, 3596, 3796, 4018], 'inhibitory': [2215], 'on': [2217, 3582, 3939, 4074], 'cells': [2220], 'case': [2222], 'e.g.': [2225], 'KIR3DL1)': [2226], 'set': [2252], 'out': [2253], 'compare': [2255], 'several': [2256, 3595], '(Table': [2259], 'terms': [2262], 'subtypes.': [2278], 'results': [2280], 'reveal': [2281], 'affinity': [2293], 'can': [2302, 2330], 'explained': [2305], 'changes': [2307, 3158], 'although': [2320], 'individual': [2322], 'contributions': [2323], 'free': [2328, 3364, 3437], 'differ': [2331, 3450, 3481], 'considerably,': [2332], 'even': [2333], 'high': [2337], 'sequence': [2338], 'similarity.': [2339], 'Furthermore,': [2340], 'find': [2342], 'affinities': [2346], 'influenced': [2348], 'expected': [2353], 'short': [2354, 4056], 'range': [2355, 2360, 3033], 'crucial': [2371], 'shaping': [2373], 'groove.TABLE': [2376], '1B*2705': [2377], 'bound': [2380, 3026], 'study': [2385, 3475], 'citation': [2387], 'after': [2388, 4022], 'each': [2389], 'abbreviation': [2390], 'represents': [2391, 3430], 'reference': [2393], 'where': [2394], 'given': [2400, 3009, 3367], 'HLA-B27/peptide': [2401, 2946], 'published.SequenceOrigin/peptideAbbreviationRRLPIFSRLHuman': [2404], 'self-peptide:': [2405, 2442, 2454], 'factor': [2408], 'response': [2409], '479–487TIS': [2412], '(13Hülsmeyer': [2413, 3666], 'Scholar)RRKWRRWHLHuman': [2441], '400–408pVIPR': [2449], '(11)RRKWRRWTLArtificial': [2450], 'pVIPRpVIPR-H8TRRRWHRWRLHuman': [2453], '412–420pGR': [2457], '(15)RRRWRRLTVViral:': [2458], '236–244pLMP2': [2465], '(14)RRRWRRLHVArtificial': [2466], 'pLMP2pLMP2-T8HRRIYDLIELViral:': [2469], '258–266pEBNA-3C': [2473], '(23)RRIYDLITLArtificial': [2474], 'calculationspEBNA-3C-E8TSRYWAIRTRViral:': [2479], '383–391flu': [2483], 'Scholar)KRWIILGLNKViral:': [2507], '263–272gag': [2510], 'Scholar)GRFAAAIAKNon-natural': [2534], 'ligandm9': [2535], 'Scholar)RRLLRGHNQYNon-natural': [2567], '110–119)S10R': [2574], 'Open': [2611], 'table': [2612], 'new': [2615], 'tab': [2616], 'Protein': [2617, 4102, 4116, 4217], 'Preparation—Complexes': [2618], 'm9,': [2628], 'pVIPR,': [2629], 'TIS,': [2630], 'pLMP2,': [2631], 'pGR,': [2633], 'artificial': [2636], 'mutants': [2638, 3529, 3951], 'pVIPR-H8T': [2639, 3532], 'pLMP2-T8H': [2641, 3530], 'were': [2642, 2931, 2949, 2983, 3143, 3172, 3580, 3735, 3878, 3936, 3952, 4072, 4155], 'prepared': [2643], 'described': [2645], 'previously': [2646, 4290], '26Garboczi': [2888], 'D.': [2889, 2891, 2893], 'Hung': [2890], 'Wiley': [2892], 'Proc.': [2894], 'Natl.': [2895], 'Acad.': [2896], 'Sci.': [2897, 4103, 4117, 4218], '1992;': [2901], '89:': [2902], '3429-3433Crossref': [2903], '(563)': [2906], 'synthetic': [2910], 'fluorescent': [2916], 'derivatives': [2917], 'labeled': [2918], '(LY,': [2922], 'Molecular': [2923], 'Probes)': [2924], 'C-6': [2927], 'C-8,': [2929], 'purchased': [2932], 'Alta': [2934], 'Bioscience': [2935], '(Birmingham,': [2936], 'UK),': [2937], 'Biosynthan': [2938], '(Berlin,': [2939], 'Germany),': [2940], 'synthesized': [2942], 'in-house.': [2943], 'Briefly,': [2944], 'heterotrimeric': [2945], '(HC/β2m/peptide)': [2948], 'reconstituted': [2950], '6': [2952], 'm': [2953], 'urea': [2954], 'After': [2962], 'size': [2963], 'exclusion': [2964, 4269], 'chromatography,': [2965], 'concentrations': [2967], 'pure': [2970], 'MHC/peptide': [2971, 3010], '10': [2974], 'mm': [2975, 2981], 'phosphate': [2976], 'buffer,': [2977], 'pH': [2978], '7.5,': [2979], '150': [2980], 'NaCl': [2982], 'adjusted': [2984], 'A426': [2986], '=': [2987, 3082], '0.0012': [2988], 'OD': [2989], 'absorption': [2992], 'band': [2993], '(λmax': [2997], '≈': [2998], '430': [2999], 'nm).': [3000], 'Thermodynamics': [3001], 'Dissociation—Temperature-induced': [3004], 'dissociation': [3006, 3250, 3379, 3397], 'was': [3012, 3074, 3078, 3090, 3266, 3959, 4020, 4041, 4185, 4318], 'measured': [3013], 'detection': [3015], 'change': [3018, 3271, 3334], 'stationary': [3021], 'anisotropy': [3022, 3089, 3141, 3182, 3202, 3223], 'LY': [3024], 'covalently': [3025], 'temperature': [3032, 3219], '85': [3037], '°C': [3038], '(16Pöhlmann': [3039, 3277], 'An': [3067], 'average': [3068], 'heating': [3069], 'rate': [3070], '0.6': [3072], '°C/min': [3073], 'applied.': [3075], 'excited': [3079], 'λex': [3081], '428': [3083], 'nm,': [3084], 'steady': [3087, 3180], 'determined': [3091, 3256, 3381, 3401], 'time-correlated': [3094], 'photon': [3096], 'counting': [3097], 'setup': [3098], '(27Alexiev': [3099], 'Rimke': [3101], '328:': [3109], '705-719Crossref': [3110], 'collecting': [3117], 'integral': [3119], 'emission': [3120], 'intensity': [3121, 3276], 'λ': [3123], '≥': [3124], '515': [3125], 'nm': [3126], 'parallel': [3127], 'I∥': [3128], 'perpendicular': [3130], 'I⊥': [3131], 'respect': [3133], 'linearly': [3136], 'polarized': [3137], 'excitation': [3138], 'light.': [3139], 'values': [3142, 3734], 'calculated': [3144, 3360, 3737], 'according': [3145], 'Equation': [3147, 3176, 3190, 3369, 3428, 3493], '1,r(t)=I∥(t)-I⊥(t)I∥(t)+2I⊥(t)(Eq.': [3148], 'Thermodynamic': [3150], 'parameters,': [3151, 3198], 'enthalpy': [3155, 3239], 'entropy': [3157, 3244, 3393], 'unfolding': [3161, 3265, 3309], 'process': [3162], 'transition': [3166, 3310, 3406], 'temperatures': [3167, 3311, 3380], '(Tm)': [3168], 'dissociation,': [3171], 'obtained': [3173, 3953], 'fitting': [3175, 3197], 'applying': [3183, 3403, 4187], 'square': [3186], 'procedure,r(T)=r0b+sbT+(r0d+sdT)exp-ΔHp0+TΔSp0RT1+exp-ΔHp0+TΔSp0RT(Eq.': [3187], '3Tm=ΔHp0ΔSp0(Eq.': [3191], '3)': [3192], 'equation': [3194, 4134, 4184], 'involves': [3195], 'six': [3196], 'respectively;': [3199], 'folded': [3205, 3542], '(native': [3207], 'protein),': [3208], 'r0b,': [3209], 'dissociated': [3215, 3235], 'state,': [3216, 3228, 3236], 'r0d,': [3217], 'dependence': [3220], 'peptide-bound': [3226], '(folded)': [3227], 'Sb,': [3229], 'Sd,': [3237], 'change,': [3240, 3245], 'ΔH0p,': [3241], 'ΔS0p,': [3246], 'two-state': [3249, 3405], 'reaction,': [3251], 'thermodynamic': [3253, 3336], 'quantities': [3254], 'being': [3255], 'midpoint': [3259], 'transition.': [3262], 'followed': [3268, 4053], 'tryptophan': [3274], 'Comparison': [3305], 'LY-labeled': [3320], '(data': [3322], 'shown)': [3324], 'indicated': [3325], 'modification': [3328, 3536], 'complex.': [3341], 'For': [3342, 3497, 4007], 'relative': [3346, 3502], 'same': [3357, 3514], 'peptide,': [3358], 'difference': [3362, 3375, 3519, 4129], 'ΔΔGB*2709-B*2705,': [3366], '4,ΔΔGB*2709-B*2705=ΔTB*2709-B*2705·ΔS¯B*27090(Eq.': [3370], '4)': [3371], 'ΔTB*2709-B*2705': [3372], 'ΔS0B*2709': [3389], 'apparent': [3392], 'reaction': [3398], 'model': [3407, 3697], '(Equation': [3408], '2).': [3409], 'According': [3410], 'Becktel': [3412], 'Shellman': [3414], '(28Becktel': [3415, 3562], 'Schellman': [3417, 3564], 'Biopolymers.': [3419, 3566], '1987;': [3420, 3567], '26:': [3421, 3568], '1859-1877Crossref': [3422, 3569], '(948)': [3425, 3572], '4': [3429, 3494, 4257], 'method': [3432], 'calculation': [3435], 'biomolecular': [3441], 'systems': [3442, 3448], 'showing': [3443], 'small': [3445, 3453, 3535], 'perturbations,': [3446], 'i.e.': [3447], 'modifications,': [3454], 'point': [3458], 'mutation': [3459], 'selective': [3462], 'ligand.': [3466], 'Because': [3467], 'acid,': [3486], 'conditions': [3488], 'use': [3491], 'fulfilled.': [3496], 'HLA-B27/pVIPR,': [3505], 'HLA-B27/pLMP2,': [3506], 'HLA-B27/pVIPR-H8T,': [3507], 'HLA-B27/pLMP2-T8H,': [3509], 'method,': [3515], 'now': [3516], 'considering': [3517], 'sequence-related': [3522], 'system.': [3539], 'protein/peptide': [3543], 'characterized': [3546], 'positive': [3549], 'ΔG': [3550], 'value,': [3551], 'destabilization': [3552], '(stabilization)': [3553], 'thus': [3554], 'appears': [3555], 'negative': [3558], '(positive)': [3559], 'ΔΔG': [3560], 'value': [3561], 'Analysis—Protein': [3576], 'calculations': [3579, 3935, 4071], 'performed': [3581, 3938], 'structures': [3585, 3890], '(pLMP2': [3598], 'both': [3631, 3940], 'canonical': [3632], '(conformation': [3633, 3637], 'A)': [3634], 'B)': [3638], 'conformations': [3639, 3797], 'TIS': [3665], 'm9': [3699], 'Scholar)).': [3731, 3836, 4006], 'S10R': [3745], 'pGR': [3791, 3801], '(pGR': [3798], 'B': [3802], '(15Rückert': [3803], '(gag)': [3840], 'HIV,': [3842], 'EBNA3C-(258–266)': [3843], '(pEBNA-3C)': [3844], 'nucleoprotein': [3849], '(flu)': [3851], 'included': [3880], 'study.': [3883], 'resolution': [3885, 4246], 'varies': [3894], '1.09': [3896], '2.30': [3898], 'Å.': [3899], 'listed': [3903], 'Table': [3905], 'To': [3907], 'understand': [3908], 'how': [3909], 'absence': [3913], 'and/or': [3917], 'influence': [3924], 'effective': [3926], 'titratable': [3931], 'groups,': [3932], 'without': [3943, 3948], 'β2m.': [3949], 'follows:': [3955], 'pHis-8': [3956, 4049], 'mutated': [3960], 'threonine': [3963], 'WHAT': [3966], 'IF': [3967], '(29Vriend': [3968], 'Graphics.': [3972], '1990;': [3973], '8:': [3974], '52-56Crossref': [3975], '(3371)': [3978], 'package': [3981], '(experimental': [3982], 'version': [3983], 'function': [3986], 'mutate': [3987], '(30Chinea': [3988], 'Padron': [3990], 'Hooft': [3992], 'Sander': [3994], 'Vriend': [3996, 4084, 4294, 4297], 'Proteins.': [3998], '415-421Crossref': [4001], '(120)': [4004], 'pThr-8': [4011, 4038], 'histidine,': [4016], 'strategy': [4019], 'adopted;': [4021], 'fit': [4023], 'backbone': [4027], 'atoms': [4028, 4154], '7': [4031], '9,': [4033], 'side': [4035, 4045], 'replaced': [4042], 'B,': [4052], 'minimization': [4058], 'steepest': [4064], 'descent': [4065], 'algorithm': [4066], '(100': [4067], 'steps).': [4068], 'based': [4073], 'scheme': [4076], 'proposed': [4077], 'Nielsen': [4079, 4292], 'et': [4080], 'al.': [4081], '(31Nielsen': [4082, 4295], 'J.E.': [4083, 4296], 'Proteins': [4086, 4299], 'Struct.': [4087, 4300], 'Funct.': [4088, 4301], 'Genet.': [4089, 4302], '2001;': [4090, 4174, 4200, 4303], '43:': [4091, 4304], '403-412Crossref': [4092, 4305], '32Nielsen': [4098, 4213], 'McCammon': [4100, 4114, 4215], '12:': [4105, 4119, 4220], '313-326Crossref': [4106, 4221], '33Nielsen': [4112], '1894-1901Crossref': [4120], 'combines': [4127], 'finite': [4128], 'solutions': [4130], 'Poisson-Boltzmann': [4133, 4183], 'global': [4137], 'optimization': [4138], 'hydrogen': [4141], 'bond': [4142], 'network': [4143], 'all': [4145], 'states.': [4147], 'All': [4148], 'radii': [4149], 'charges': [4151], 'taken': [4156], 'OPLS': [4159], 'force': [4160], 'field': [4161], '(34Kaminski': [4162], 'Friesner': [4164], 'Tirado-Rives': [4166], 'Jorgensen': [4168], 'Phys.': [4171, 4197], '105:': [4175, 4201], '6474-6487Crossref': [4176], '(3194)': [4178], 'linearized': [4182], 'solved': [4186], 'DELPHI': [4188], 'II': [4189], '(35Rocchia': [4190], 'Alexov': [4192], 'Honig': [4194], '6507-6514Crossref': [4202], '(704)': [4204], 'parameters': [4209], 'Ref.': [4212], 'Scholar;': [4226], 'dielectric': [4228, 4314], 'constant': [4229, 4315], '80': [4231], 'water': [4233], '8': [4235], 'interior,': [4239], '65': [4241], 'cubed': [4242], 'grid,': [4243], 'grid': [4245, 4249, 4258], '3': [4248], 'points/Å': [4250, 4259], 'desolvation': [4253], 'background': [4262], 'energy,': [4264], '2.0': [4266], 'Å': [4267, 4284], 'ion': [4268], 'layer,': [4270], 'ionic': [4272], '0.144': [4275], 'm,': [4276], 'probe': [4280], 'radius': [4281], '1.4': [4283], 'used.': [4287], 'suggested': [4289], 'locally': [4312], 'increased': [4313], '16': [4317], 'applied': [4319]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2035426331', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T02:11:13.179797', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
