Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2035375871', 'doi': 'https://doi.org/10.1097/01.shk.0000174936.51903.7d', 'title': 'ENDOTHELIAL DYSFUNCTION IN TRAUMA PATIENTS: A PRELIMINARY COMMUNICATION', 'display_name': 'ENDOTHELIAL DYSFUNCTION IN TRAUMA PATIENTS: A PRELIMINARY COMMUNICATION', 'publication_year': 2005, 'publication_date': '2005-08-31', 'ids': {'openalex': 'https://openalex.org/W2035375871', 'doi': 'https://doi.org/10.1097/01.shk.0000174936.51903.7d', 'mag': '2035375871', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16135958'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.shk.0000174936.51903.7d', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S174819509', 'display_name': 'Shock', 'issn_l': '1073-2322', 'issn': ['1073-2322', '1540-0514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1097/01.shk.0000174936.51903.7d', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113681935', 'display_name': 'M. Mathru', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}, {'id': 'https://openalex.org/I55302922', 'display_name': 'The University of Texas Medical Branch at Galveston', 'ror': 'https://ror.org/016tfm930', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55302922']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Mali Mathru', 'raw_affiliation_strings': ['Department of Anesthesiology, University of Alabama, Birmingham, Alabama', 'Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, University of Alabama, Birmingham, Alabama', 'institution_ids': ['https://openalex.org/I32389192']}, {'raw_affiliation_string': 'Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas', 'institution_ids': ['https://openalex.org/I55302922']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024566519', 'display_name': 'John D. Lang', 'orcid': 'https://orcid.org/0000-0001-9220-565X'}, 'institutions': [{'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John D Lang', 'raw_affiliation_strings': ['Department of Anesthesiology, University of Alabama, Birmingham, Alabama'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, University of Alabama, Birmingham, Alabama', 'institution_ids': ['https://openalex.org/I32389192']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5113681935'], 'corresponding_institution_ids': ['https://openalex.org/I32389192', 'https://openalex.org/I55302922'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.641, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.742689, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '24', 'issue': '3', 'first_page': '210', 'last_page': '213'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10706', 'display_name': 'Traumatic Brain Injury and Neurovascular Disturbances', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10706', 'display_name': 'Traumatic Brain Injury and Neurovascular Disturbances', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10745', 'display_name': 'Heart Rate Variability and Autonomic Control', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10645', 'display_name': 'Cardiac Arrest and Resuscitation', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2711', 'display_name': 'Emergency Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/brachial-artery', 'display_name': 'Brachial artery', 'score': 0.8642285}, {'id': 'https://openalex.org/keywords/reactive-hyperemia', 'display_name': 'Reactive hyperemia', 'score': 0.83703935}, {'id': 'https://openalex.org/keywords/endothelial-dysfunction', 'display_name': 'Endothelial Dysfunction', 'score': 0.5754205}], 'concepts': [{'id': 'https://openalex.org/C2777604165', 'wikidata': 'https://www.wikidata.org/wiki/Q503643', 'display_name': 'Brachial artery', 'level': 3, 'score': 0.8642285}, {'id': 'https://openalex.org/C3019128504', 'wikidata': 'https://www.wikidata.org/wiki/Q948806', 'display_name': 'Reactive hyperemia', 'level': 3, 'score': 0.83703935}, {'id': 'https://openalex.org/C2778165595', 'wikidata': 'https://www.wikidata.org/wiki/Q5491454', 'display_name': 'Resuscitation', 'level': 2, 'score': 0.8180102}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.816196}, {'id': 'https://openalex.org/C2776992346', 'wikidata': 'https://www.wikidata.org/wiki/Q111140', 'display_name': 'Endothelium', 'level': 2, 'score': 0.6671284}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.60593474}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.59577876}, {'id': 'https://openalex.org/C2780972559', 'wikidata': 'https://www.wikidata.org/wiki/Q550061', 'display_name': 'Endothelial dysfunction', 'level': 2, 'score': 0.5754205}, {'id': 'https://openalex.org/C120770815', 'wikidata': 'https://www.wikidata.org/wiki/Q14859627', 'display_name': 'Vasodilation', 'level': 2, 'score': 0.45659387}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.39932293}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3883686}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.24500173}], 'mesh': [{'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015992', 'descriptor_name': 'Body Mass Index', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006439', 'descriptor_name': 'Hemodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009573', 'descriptor_name': 'Nitrites', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009573', 'descriptor_name': 'Nitrites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005996', 'descriptor_name': 'Nitroglycerin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005996', 'descriptor_name': 'Nitroglycerin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030421', 'descriptor_name': 'Peroxynitrous Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030421', 'descriptor_name': 'Peroxynitrous Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015427', 'descriptor_name': 'Reperfusion Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012151', 'descriptor_name': 'Resuscitation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013481', 'descriptor_name': 'Superoxides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013481', 'descriptor_name': 'Superoxides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.shk.0000174936.51903.7d', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S174819509', 'display_name': 'Shock', 'issn_l': '1073-2322', 'issn': ['1073-2322', '1540-0514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://journals.lww.com/shockjournal/Fulltext/2005/09000/ENDOTHELIAL_DYSFUNCTION_IN_TRAUMA_PATIENTS__A.3.aspx', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16135958', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.shk.0000174936.51903.7d', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S174819509', 'display_name': 'Shock', 'issn_l': '1073-2322', 'issn': ['1073-2322', '1540-0514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1965148671', 'https://openalex.org/W1965754431', 'https://openalex.org/W1973337108', 'https://openalex.org/W1980445357', 'https://openalex.org/W1980895604', 'https://openalex.org/W2003722412', 'https://openalex.org/W2014423374', 'https://openalex.org/W2025014480', 'https://openalex.org/W2030279976', 'https://openalex.org/W2050922265', 'https://openalex.org/W2058610272', 'https://openalex.org/W2059279349', 'https://openalex.org/W2063506869', 'https://openalex.org/W2069374431', 'https://openalex.org/W2072284181', 'https://openalex.org/W2073898414', 'https://openalex.org/W2087823687', 'https://openalex.org/W2093518775', 'https://openalex.org/W2099031861', 'https://openalex.org/W2109773828', 'https://openalex.org/W2113446450', 'https://openalex.org/W2131868847', 'https://openalex.org/W2149837656', 'https://openalex.org/W2156971098', 'https://openalex.org/W2156979928', 'https://openalex.org/W2161635709', 'https://openalex.org/W2169182236', 'https://openalex.org/W2177092899', 'https://openalex.org/W2275007566', 'https://openalex.org/W2289992901', 'https://openalex.org/W2407276115', 'https://openalex.org/W2412065523', 'https://openalex.org/W308319896', 'https://openalex.org/W4231582364', 'https://openalex.org/W4239562166', 'https://openalex.org/W63530261'], 'related_works': ['https://openalex.org/W3021111137', 'https://openalex.org/W2580489738', 'https://openalex.org/W2393293160', 'https://openalex.org/W2379516645', 'https://openalex.org/W23664147', 'https://openalex.org/W2364805604', 'https://openalex.org/W2357630318', 'https://openalex.org/W2354807174', 'https://openalex.org/W2127450054', 'https://openalex.org/W2045771033'], 'abstract_inverted_index': {'Global': [0], 'ischemia,': [1], 'followed': [2, 74], 'by': [3, 11, 75, 150, 157, 221], 'reperfusion': [4], 'during': [5], 'resuscitation,': [6], 'leads': [7], 'to': [8], 'cellular': [9], 'damage': [10], 'generating': [12], 'toxic': [13], 'reactive': [14, 151], 'metabolites': [15], 'that': [16, 36, 86], 'includes,': [17], 'but': [18], 'is': [19, 67, 89], 'not': [20, 178, 224], 'exclusive': [21], 'to,': [22], 'superoxide': [23], 'radical.': [24], 'Superoxide': [25], 'decreases': [26], 'the': [27, 123], 'bioavailability': [28, 43], 'of': [29, 41, 44, 56, 122, 159], 'nitric': [30], 'oxide': [31], '(NO)': [32], 'via': [33], 'its': [34], 'reaction': [35], 'yields': [37], 'peroxynitrite.': [38], 'The': [39], 'observation': [40], 'decreased': [42], 'NO,': [45], 'and': [46, 58, 109, 135, 153, 173, 230], 'attenuated': [47], 'endothelium-dependent': [48, 87, 118, 147], 'relaxation': [49, 88], 'have': [50], 'been': [51], 'observed': [52], 'in': [53, 69, 91, 114, 128, 137, 170, 174, 194, 201], 'animal': [54], 'models': [55], 'trauma': [57, 92, 130, 171, 195, 228], 'resuscitation.': [59, 77], 'However,': [60, 217], 'it': [61], 'remains': [62], 'unknown': [63], 'whether': [64], 'endothelium-mediated': [65], 'vasodilation': [66], 'impaired': [68, 90, 193], 'humans': [70], 'after': [71], 'traumatic': [72], 'hemorrhage': [73], 'crystalloid': [76, 99], 'Based': [78], 'on': [79], 'these': [80], 'previously': [81], 'established': [82], 'precepts,': [83], 'we': [84], 'hypothesized': [85], 'patients': [93, 172, 196, 229], 'despite': [94, 197], 'adequate': [95], 'fluid': [96, 198], 'resuscitation': [97, 199], 'with': [98], 'solutions.': [100], 'Baseline': [101, 143], 'characteristics': [102], 'such': [103], 'as': [104], 'age,': [105], 'body': [106], 'mass': [107], 'index,': [108], 'blood': [110], 'pressure': [111], 'being': [112], 'similar': [113], 'both': [115], 'groups,': [116], 'NO-mediated,': [117], 'flow-mediated': [119], 'dilation': [120, 155, 219], '(FMD)': [121], 'brachial': [124, 144, 182], 'artery': [125, 145, 165, 183], 'was': [126, 191, 223], 'examined': [127], 'resuscitated': [129], 'victims': [131], '(n': [132, 140], '=': [133, 141], '13)': [134], 'compared': [136], 'normal': [138], 'controls': [139], '12).': [142], 'diameter,': [146], 'FMD': [148], 'induced': [149, 156, 220], 'hyperemia': [152], 'endothelium-independent': [154, 218], 'administration': [158], 'sublingual': [160], 'nitroglycerin': [161, 222], 'were': [162, 177], 'measured.': [163], 'Brachial': [164], 'diameter': [166], 'measured': [167], 'at': [168], 'baseline': [169], 'control': [175], 'subjects': [176], 'dissimilar.': [179], 'In': [180], 'conclusion,': [181], 'FMD,': [184], 'a': [185], 'surrogate': [186], 'for': [187], 'NO-mediated': [188], 'endothelial': [189], 'function,': [190], 'significantly': [192, 225], 'resulting': [200], 'stable': [202], 'hemodynamics': [203], '(0.8': [204], '±': [205, 210], '1.7': [206], 'mm': [207], 'vs.': [208], '5.7': [209], '0.8': [211], 'mm,': [212], 'respectively;': [213], 'P': [214], '<': [215], '0.05)': [216], 'different': [226], 'between': [227], 'controls.': [231]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2035375871', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2025-01-04T14:38:50.166581', 'created_date': '2016-06-24'}