Publication Information

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3244, 3247, 3288, 3308, 3338, 3359, 3381, 3457, 3506, 3560, 3593, 3602, 3625, 3632, 3643, 3647, 3657, 3665, 3715, 3811, 3820, 3824, 3836, 3850, 3882, 3887, 3918, 3945, 3990, 3993, 3997, 4052, 4094, 4132, 4189, 4208, 4215, 4227, 4235, 4239, 4247, 4309, 4415, 4427, 4439, 4457, 4462, 4471], 'National': [5, 154, 333, 1125, 2993, 4125], 'Cancer': [6, 155, 329, 334, 500, 554, 828, 877, 1126, 1219, 1485, 2230, 2280, 2779, 2994, 3080, 3857, 4126], 'Institute': [7, 156, 1127, 2995, 4127], '(NCI)': [8, 157], 'sponsored': [9, 158], 'a': [10, 60, 77, 123, 159, 209, 226, 272, 461, 733, 765, 801, 978, 982, 1055, 1173, 1188, 1192, 1228, 1265, 1366, 1389, 1573, 1588, 1632, 1655, 1662, 1701, 1714, 1764, 1810, 1834, 1929, 1943, 1950, 1956, 1964, 2004, 2029, 2044, 2126, 2133, 2139, 2260, 2314, 2346, 2366, 2384, 2405, 2448, 2522, 2630, 2698, 2827, 2833, 2888, 2919, 2940, 2950, 3145, 3236, 3270, 3315, 3460, 3464, 3499, 3529, 3620, 3660, 3755, 3781, 3828, 3908, 4065, 4170, 4180, 4315, 4333, 4336, 4388, 4431], '2-day': [11, 160], 'workshop': [12, 70, 161, 219], 'with': [13, 162, 453, 586, 758, 764, 872, 1011, 1365, 1410, 1575, 1867, 1895, 1931, 1939, 2170, 2304, 2476, 2847, 2926, 2979, 3031, 3066, 3076, 3135, 3402, 3535, 3578, 3678, 3701, 3739, 3746, 3765, 3771, 3832, 3870, 3884, 4131, 4165, 4252, 4430], 'NCI': [15, 141, 164, 290, 4296], 'Thoracic': [16, 165], 'Malignancies': [17, 166], 'Steering': [18, 167], 'Committee': [19, 168], 'and': [20, 23, 33, 39, 62, 65, 98, 125, 169, 172, 182, 188, 211, 214, 247, 274, 405, 515, 568, 593, 617, 654, 700, 718, 741, 850, 911, 988, 1086, 1112, 1191, 1233, 1351, 1384, 1455, 1530, 1601, 1610, 1653, 1661, 1696, 1787, 1820, 1887, 1890, 1902, 1921, 1979, 1987, 1990, 2016, 2034, 2043, 2065, 2078, 2085, 2087, 2111, 2150, 2162, 2172, 2188, 2220, 2256, 2276, 2306, 2313, 2398, 2410, 2425, 2472, 2495, 2534, 2538, 2566, 2590, 2594, 2648, 2653, 2664, 2666, 2673, 2694, 2712, 2732, 2790, 2797, 2799, 3078, 3192, 3279, 3297, 3346, 3414, 3495, 3538, 3590, 3628, 3641, 3663, 3692, 3754, 3835, 3861, 3878, 3913, 3966, 4012, 4068, 4121, 4129, 4140, 4146, 4175, 4177, 4217, 4234, 4262, 4287, 4343, 4391, 4408, 4411, 4617], 'Food': [22, 171, 616, 1786, 2789], 'Drug': [24, 173, 618, 1788, 2791], 'Administration': [25, 174, 619, 1789, 2792], 'to': [26, 36, 72, 84, 99, 105, 120, 130, 175, 185, 221, 233, 248, 254, 269, 279, 607, 660, 715, 745, 784, 942, 1469, 1578, 1580, 1586, 1595, 1606, 1638, 1651, 1700, 1772, 1785, 1910, 1941, 1948, 2022, 2047, 2120, 2191, 2259, 2363, 2377, 2420, 2440, 2469, 2561, 2564, 2585, 2602, 2620, 2681, 2703, 2718, 2727, 2736, 2750, 2897, 2904, 3178, 3186, 3193, 3200, 3210, 3234, 3272, 3283, 3317, 3327, 3352, 3379, 3386, 3421, 3434, 3453, 3485, 3497, 3511, 3553, 3562, 3571, 3580, 3591, 3613, 3655, 3675, 3743, 3768, 3788, 3795, 3822, 3826, 3838, 3975, 3988, 4001, 4023, 4029, 4084, 4092, 4113, 4134, 4172, 4178, 4182, 4212, 4220, 4241, 4260, 4265, 4290, 4352, 4360, 4387, 4396, 4447, 4454, 4456, 4483, 4501, 4508, 4517], 'bring': [27, 176], 'together': [28, 177], 'leading': [29, 104, 178, 253, 1784, 4289], 'academicians,': [30, 179], 'clinicians,': [31, 180], 'industry': [32, 181, 2089, 2501, 2796, 4237], 'government': [34, 183], 'representatives': [35, 184, 2502], 'identify': [37, 186, 925, 2378, 2893], 'challenges': [38, 187, 2000], 'potential': [40, 189, 566, 599, 663, 1577], 'solutions': [41, 190], 'in': [42, 92, 191, 241, 301, 316, 449, 469, 494, 511, 591, 622, 672, 732, 967, 1008, 1013, 1028, 1064, 1082, 1117, 1135, 1167, 1221, 1269, 1371, 1399, 1443, 1503, 1547, 1614, 1713, 1794, 1898, 1963, 2013, 2095, 2250, 2272, 2309, 2327, 2374, 2521, 2528, 2606, 2684, 2832, 2878, 2915, 2929, 2976, 3003, 3029, 3069, 3100, 3204, 3262, 3281, 3298, 3377, 3423, 3440, 3459, 3474, 3528, 3550, 3576, 3737, 3763, 3803, 3842, 3922, 3931, 3992, 4005, 4014, 4031, 4064, 4163, 4515], 'clinical': [44, 81, 193, 230, 418, 492, 535, 548, 579, 734, 822, 870, 893, 1615, 1658, 1865, 1916, 2189, 2206, 2224, 2577, 2627, 2676, 2687, 2707, 3205, 3291, 3391, 3424, 3476, 3568, 3605, 3639, 4123, 4148], 'development': [45, 127, 194, 276, 536, 642, 1989, 2018, 2183, 2199, 2371, 2570, 2593, 2935, 2945, 3263, 3979, 4103, 4190], 'of': [46, 54, 68, 89, 102, 107, 117, 128, 146, 195, 203, 217, 238, 251, 256, 266, 277, 295, 360, 433, 522, 537, 577, 601, 621, 650, 657, 670, 694, 704, 751, 798, 1115, 1128, 1158, 1203, 1231, 1237, 1346, 1387, 1394, 1402, 1413, 1446, 1452, 1463, 1550, 1565, 1599, 1670, 1685, 1694, 1718, 1747, 1760, 1763, 1782, 1792, 1817, 1824, 1827, 1841, 1904, 1918, 1924, 1953, 1981, 1992, 2006, 2009, 2019, 2040, 2053, 2142, 2184, 2226, 2252, 2269, 2274, 2292, 2297, 2302, 2337, 2372, 2383, 2443, 2514, 2541, 2552, 2596, 2609, 2637, 2655, 2724, 2760, 2821, 2887, 2900, 2918, 2936, 2943, 2949, 2964, 2968, 2996, 3059, 3175, 3183, 3190, 3207, 3225, 3246, 3249, 3264, 3307, 3310, 3355, 3383, 3426, 3463, 3480, 3501, 3508, 3574, 3587, 3595, 3604, 3637, 3646, 3659, 3750, 3775, 3784, 3797, 3808, 3810, 3846, 3853, 3881, 3947, 3980, 3996, 4008, 4054, 4098, 4104, 4157, 4191, 4197, 4305, 4327, 4335, 4349, 4414, 4443, 4461, 4470, 4497, 4505, 4512], 'novel': [47, 196, 2020, 3627, 4316], 'targeted': [48, 90, 197, 239, 552, 826, 962, 979, 1344, 1499, 3493, 3503, 3509, 4353, 4362], 'therapies': [49, 198, 1793, 4514], 'for': [50, 199, 319, 351, 533, 551, 674, 679, 697, 777, 793, 825, 844, 896, 994, 1106, 1197, 1382, 1501, 1518, 1592, 1665, 1863, 1984, 2051, 2093, 2197, 2223, 2532, 2573, 2650, 2662, 2669, 2706, 2729, 2795, 2817, 2849, 3133, 3276, 3405, 3416, 3436, 3687, 3699, 3904, 3939, 3973, 4046, 4048, 4194, 4285, 4293, 4302, 4325, 4373], 'lung': [51, 95, 200, 244, 306, 353, 362, 386, 457, 1031, 1139, 1271, 1408, 1519, 1795, 1934, 1985, 2014, 2851, 2982, 3007, 3034, 3072, 3140, 3250, 3387, 3690, 4198, 4274, 4307], 'cancer.': [52, 201, 3251, 4167], 'Measures': [53, 202], 'success': [55, 204, 2094], 'are': [56, 205, 413, 529, 712, 806, 992, 1068, 1325, 1448, 1497, 1622, 1674, 1849, 1973, 2091, 2168, 2358, 2428, 2743, 3064, 3170, 3177, 3332, 3349, 3408, 3419, 3491, 3642, 3664, 3929, 4258], 'rapidly': [57, 85, 206, 234, 2097, 4267, 4284], 'evolving': [58, 207, 2777], 'from': [59, 208, 460, 930, 2202, 3287, 3358, 3371, 4051], 'scientific': [61, 210, 3448], 'regulatory': [63, 212, 1999, 2055, 2083], 'perspective': [64, 213, 2772], 'objectives': [67, 216], 'this': [69, 147, 218, 296, 308, 1074, 1171, 2096, 2462, 2617, 3847, 4319, 4498], 'were': [71, 142, 220, 291, 1225, 2248, 3729], 'achieve': [73, 222, 1942], 'initial': [74, 223], 'consensus': [75, 224, 4171], 'on': [76, 115, 225, 264, 340, 900, 916, 1200, 1243, 1257, 1293, 1314, 1450, 1460, 1642, 1914, 2108, 2332, 2616, 2773, 2826, 3373, 3398, 4368], 'high': [78, 227, 702], 'priority': [79, 228], 'biomarker-driven': [80, 229, 595, 4105, 4375], 'trial': [82, 124, 231, 273, 419, 549, 735, 808, 823, 842, 909, 940, 1093, 1176, 1213, 1268, 1349, 1393, 1546, 1689, 1766, 2241, 2348, 2356, 2368, 2578, 3318, 3462, 3569, 3648, 3698, 3757, 3805, 3866, 4301, 4499], 'designed': [83, 232, 2069], 'assess': [86, 235, 661, 3592], 'activity': [88, 237, 585, 4425], 'agents': [91, 240, 2021, 2867, 2928, 3504, 3510], 'molecularly': [93, 242], 'defined': [94, 243, 2524], 'cancer': [96, 245, 354, 363, 387, 1409, 1545, 1796, 1920, 1935, 1986, 2015, 2450, 2983, 3073, 3141, 3388, 4199, 4275], 'subsets': [97, 246, 1451, 1462], 'facilitate': [100, 249], 'generation': [101, 250, 576], 'data': [103, 252, 344, 1454, 1465, 2063, 2196, 2311, 2357, 2670], 'approval': [106, 255, 1791, 2104, 4286, 4511], 'these': [108, 257, 748, 1993, 2024, 2761, 3374, 3406, 3934, 4060, 4099, 4381], 'new': [109, 258, 399, 409, 538, 2453, 3167, 3311, 3428, 4222, 4280, 4361, 4513], 'therapies.': [110, 259], 'Additionally,': [111, 260], 'meeting': [113, 262, 2505], 'focused': [114, 263], 'identification': [116, 265, 2948], 'barriers': [119, 268], 'conduct': [121, 270, 2654, 3211], 'such': [122, 271, 1369, 2157, 2164, 3257, 3330, 3475, 3514, 4158, 4243, 4314], 'strategies': [129, 278], 'overcome': [131, 280, 3194], 'those': [132, 281, 4037], 'barriers.': [133, 282], 'The': [134, 283, 431, 691, 907, 1283, 1480, 1814, 2057, 2290, 2880, 2911, 2934, 3252, 3362, 3520, 3609, 3709, 3844, 3864, 4295, 4418, 4435, 4495], '"Lung': [135, 284], 'Master': [136, 285], 'Protocols"': [137, 286, 4193], 'recently': [138, 287], 'launched': [139, 288], 'by': [140, 289, 645, 795, 1215, 1405, 2031, 2582, 2746, 2763, 2814, 2947, 3337, 3707, 3733, 3759, 3819, 4277, 4332, 4464], 'direct': [144, 293], 'outcome': [145, 294, 318, 1862, 3845], 'workshop.': [148, 297], 'Despite': [298], 'rapid': [299, 534, 592, 641], 'progress': [300, 3549], 'identifying': [302], 'molecular': [303, 372, 527, 677, 2011, 2525, 3546, 4329], 'abnormalities': [304, 4330, 4350, 4383], 'driving': [305], 'cancer,': [307, 4308], 'has': [309, 1797, 2027, 2145, 2152, 2558, 2883, 4473, 4480], 'not': [310, 713, 965, 1161, 1305, 1326, 1623, 1970, 2137, 2464, 2555, 2874, 2932, 3334, 4484], 'yet': [311], 'been': [312, 1798, 2028, 2559, 2884, 4481], 'translated': [313], 'into': [314, 1163, 3566], 'improvement': [315, 1897], 'long-term': [317], 'patients.1Howlader': [320], 'N,': [321], 'Noone': [322], 'AM,': [323], 'Krapcho': [324], 'M,': [325], 'et': [326, 443, 1024, 1133, 1253, 1380, 1512, 1539, 2843, 2961, 3001, 3054, 3096, 3126], 'al.': [327, 2962], 'SEER': [328, 343], 'Statistics': [330], 'Review,': [331], '1975-2011,': [332], 'Institute.': [335], 'Bethesda,': [336], 'MD,': [337], 'http://seer.cancer.gov/csr/1975_2011/,': [338], 'based': [339, 1242, 1256, 2107, 2825, 3397, 3534, 3544, 4367], 'November': [341], '2013': [342], 'submission.': [345], 'Accessed': [346], 'April.': [347], '2014Google': [348], 'Scholar': [349, 397, 430, 509, 563, 640, 690, 906, 955, 1043, 1151, 1282, 1433, 1494, 1529, 1562, 1758, 1880, 2239, 2289, 2810, 2863, 3165], 'Treatment': [350], 'non–small-cell': [352], '(NSCLC)': [355], 'that': [356, 519, 708, 719, 810, 920, 960, 1194, 1324, 1618, 1621, 1636, 1675, 2103, 2165, 2244, 2632, 2754, 2868, 2891, 2914, 3214, 3256, 3365, 3523, 3539, 3780, 4021, 4090, 4109, 4257, 4479], 'comprises': [357], 'about': [358, 676, 1049, 3472, 3793], '80%': [359], 'cases': [364], 'is': [365, 643, 743, 756, 958, 1046, 1172, 1195, 1211, 1303, 1335, 1584, 1604, 1631, 1649, 1806, 1843, 1907, 1959, 1969, 1995, 2125, 2418, 2549, 2580, 2600, 2629, 2644, 2931, 3228, 3269, 3445, 3452, 3552, 3849, 4019, 4111, 4238, 4312, 4446, 4451, 4500], 'shifting': [366], 'toward': [367, 2036, 3394], 'regimens': [368], 'targeting': [369], 'relatively': [370], 'uncommon': [371], 'alterations': [373, 3916, 3928, 4061], 'rather': [374], 'than': [375, 1337, 1342, 1706, 1955], 'traditional': [376, 1174], 'histologic': [377], 'subtypes.2Pao': [378], 'W': [379, 1477], 'Hutchinson': [380], 'KE': [381], 'Chipping': [382], 'away': [383], 'at': [384, 2503, 3239, 3601, 4089], 'genome.Nat': [388], 'Med.': [389, 1035, 1143, 2855, 3011, 3105], '2012;': [390, 502], '18:': [391], '349-351Crossref': [392], 'PubMed': [393, 426, 480, 505, 559, 636, 686, 833, 858, 882, 951, 1039, 1147, 1278, 1429, 1490, 1525, 1558, 1736, 1876, 2235, 2285, 2784, 2859, 3015, 3085, 3109, 3161], 'Scopus': [394, 427, 481, 506, 560, 637, 687, 834, 859, 883, 952, 1040, 1148, 1279, 1430, 1491, 1526, 1559, 1737, 1755, 1877, 2236, 2286, 2785, 2860, 3016, 3086, 3110, 3162], '(166)': [395], 'Google': [396, 429, 483, 508, 562, 639, 689, 836, 861, 885, 954, 1042, 1150, 1281, 1432, 1493, 1528, 1561, 1739, 1757, 1879, 2238, 2288, 2787, 2862, 3018, 3040, 3088, 3112, 3164], 'This': [398, 3313, 3411, 3467, 4270], 'complexity': [400], 'raises': [401], 'patient': [402, 513, 609, 1088, 1199, 1899, 1930, 1957, 1976, 3319, 3395, 3470, 3983], 'selection,': [403], 'accrual': [404, 3320], 'funding': [406], 'challenges,': [407, 3329], 'so': [408, 497, 1617], 'more': [410, 786, 1336, 1341, 1355, 1640, 2079, 4253, 4266, 4283], 'efficient': [411], 'approaches': [412], 'essential.3Collier': [414], 'R': [415, 1479, 2840, 2956, 2959], 'Rapidly': [416], 'rising': [417], 'costs': [420, 703, 2540], 'worry': [421], 'researchers.CMAJ.': [422], '2009;': [423, 855, 1555, 2282, 3106], '180:': [424], '277-278Crossref': [425], '(61)': [428], 'predominance': [432], 'negative': [434, 3404], 'Phase': [435, 2834, 4299, 4440, 4458, 4467], 'III': [436, 491, 547, 821, 1267, 1392, 2835, 4459, 4468], 'trials4Thatcher': [437], 'N': [438, 3049], 'Chang': [439], 'A': [440, 540, 729, 753, 768, 814, 1178, 2114, 2626, 2675, 2838, 3478, 3815], 'Parikh': [441], 'P': [442], 'al.Gefitinib': [444, 3097], 'plus': [445], 'best': [446, 776, 3994], 'supportive': [447], 'care': [448], 'previously': [450, 1136, 3004], 'treated': [451, 1137, 3005, 3075], 'patients': [452, 761, 794, 926, 990, 1010, 1067, 1105, 1186, 1224, 1292, 1313, 1403, 1641, 1686, 1719, 1911, 2255, 2303, 2390, 2412, 2738, 2894, 2978, 3030, 3074, 3134, 3384, 3401, 3417, 3455, 3540, 3700, 3738, 3764, 3785, 3799, 3869, 3935, 4004, 4025, 4130, 4164, 4261, 4321, 4355], 'refractory': [454], 'advanced': [455, 1029, 1406, 2822, 3136, 3689, 3703], 'non-small-cell': [456, 1138, 1270, 1407, 2850, 3006, 3139], 'cancer:': [458], 'results': [459, 1680, 1882], 'randomised,': [462], 'placebo-controlled,': [463], 'multicentre': [464], 'study': [465, 1385, 1574, 2116, 2129, 2254, 2389, 2836, 3254, 3339, 3633, 3744, 3769, 3840, 4067, 4472], '(Iressa': [466], 'Survival': [467], 'Evaluation': [468], 'Lung': [470, 1218, 1419, 3856], 'Cancer).Lancet.': [471], '2005;': [472, 628, 1144, 3012, 3037], '366:': [473], '1527-1537Abstract': [474], 'Full': [475, 477, 631, 633, 1424, 1426, 3156, 3158], 'Text': [476, 478, 632, 634, 1425, 1427, 3157, 3159], 'PDF': [479, 635, 1428, 3160], '(2001)': [482], 'Scholar,5Laleh': [484], 'A-K': [485], 'Tito': [486], 'F': [487, 1377], 'Why': [488], 'do': [489, 763], 'phase': [490, 546, 820, 1266, 1391, 3149], 'trials': [493, 580, 871, 1567, 1616, 1783, 1866, 2058, 2190, 2925, 3206, 3292, 3392, 3425, 3686, 3726, 4149, 4245, 4256], 'oncology': [495, 3323, 4232], 'fail': [496], 'often?.J': [498], 'Natl': [499, 876, 2229, 2279], 'Inst.': [501, 878, 2231, 2281], '104:': [503], '568-569Crossref': [504], '(40)': [507], 'conducted': [510, 1214], 'unselected': [512], 'populations': [514], 'recent': [517], 'findings': [518, 2167], 'majority': [521], 'NSCLC': [523, 1009, 1223, 2824, 2930, 3551, 3704], "patients'": [524, 3899], 'tumors': [525, 3900, 4058, 4070, 4379], 'harbor': [526], '"drivers"': [528], 'changing': [530], 'paradigm': [532, 3530], 'therapies.6Hoering': [539], 'LeBlanc': [541, 815], 'M': [542, 816, 1248, 2953], 'Crowley': [543, 817], 'J': [544, 818, 1034, 1122, 1142, 2854, 2990, 3010, 3104, 3121], 'Randomized,': [545, 819], 'designs': [550, 809, 824, 843, 1350, 1673, 1767, 1819, 3537], 'agents.Clin': [553, 827], 'Res.': [555, 829, 1486, 2780, 3036, 3081], '2008;': [556, 830], '14:': [557, 831], '4358-4367Crossref': [558, 832], '(85)': [561, 835], 'By': [564], 'incorporating': [565], 'biomarkers': [567, 782, 873, 1437, 2902, 3227, 3565], 'assessing': [569], 'pharmacokinetic': [570], '(PK)/pharmacodynamic': [571], '(PD)': [572], 'effects,': [573], 'next': [575], 'early': [578, 1932, 2370, 3585], 'can': [581, 736, 790, 811, 923, 997, 1070, 1079, 1153, 1287, 1353, 1360, 1466, 1568, 1625, 2200, 2401, 2492], 'quickly': [582], 'establish': [583], 'agent': [584, 1581, 3718, 4399, 4506], 'smaller': [587], 'sample': [588, 1704, 2434], 'sizes': [589], 'resulting': [590, 1712], 'cost-effective': [594], 'development.': [596, 2544], 'While': [597], 'utility': [600, 3594], '"companion"': [602], 'diagnostics': [603, 2589], 'opens': [604], 'door': [606], 'optimal': [608, 2177], 'selection,7Mansfield': [610], 'E': [611], "O'Leary": [612], 'TJ': [613], 'Gutman': [614], 'SI': [615], 'regulation': [620], 'vitro': [623, 2375, 2804], 'diagnostic': [624, 698, 2088, 2376, 2543, 2598, 2806], 'devices.J': [625], 'Mol': [626], 'Diagn.': [627], '7:': [629], '2-7Abstract': [630], '(39)': [638], 'hindered': [644], 'intratumoral': [646], 'heterogeneity,': [647], 'low': [648], 'frequency': [649], 'responsible': [651], 'driver': [652], 'mutations,': [653], 'variety': [656], 'tests': [658, 706, 711], 'available': [659, 696], 'each': [662, 1198, 1593, 3804, 4347, 4374, 4444], 'target': [664, 2023, 2869, 4428], '(analyte).8Ransohoff': [665], 'DF': [666, 2267], 'Gourlay': [667], 'ML': [668], 'Sources': [669], 'bias': [671], 'specimens': [673, 2247, 2271, 3296, 3357, 3813], 'research': [675], 'markers': [678, 1447, 2731, 2742, 3407], 'cancer.J': [680, 1272], 'Clin': [681, 853, 946, 1273, 1731, 1750, 1871], 'Oncol.': [682, 854, 947, 1274, 1732, 1751, 1872, 3152], '2010;': [683, 879, 1487], '28:': [684], '698-704Crossref': [685], '(156)': [688], 'limited': [692], 'amount': [693], 'tissue': [695, 1109, 2433, 2482, 2725], 'use': [699, 2608, 3658], 'individual': [705, 710, 779], 'mean': [707], 'sequential': [709], 'likely': [714, 2351], 'be': [716, 727, 737, 785, 812, 998, 1071, 1080, 1288, 1467, 1569, 1626, 1884, 1893, 1946, 2067, 2106, 2118, 2352, 2402, 2414, 2436, 2465, 2480, 2493, 2562, 2679, 2692, 2704, 2710, 3198, 3232, 3432, 3532, 3542, 3676, 3789, 3801, 3902, 3937, 4027, 4044, 4082, 4250, 4323, 4357, 4385, 4393, 4486], 'feasible': [717], 'multiplexed': [720], 'assays': [721, 2491, 2753, 2762, 3667], 'or': [722, 739, 981, 1205, 1240, 1340, 2073, 2132, 2204, 2342, 2381, 2846, 3098, 3341, 3606, 3721, 3953, 3985, 4364], 'next-generation': [723, 4338], 'DNA': [724, 4088, 4339], 'sequencing': [725, 4340], 'may': [726, 1297, 1677, 1698, 1945, 2066, 2117, 2451, 2463, 2496], 'required.': [728], 'biomarker': [730, 755, 770, 846, 922, 943, 996, 1166, 1182, 1207, 1284, 1339, 1666, 2185, 2198, 2246, 2328, 2394, 2399, 2424, 2498, 2890, 3212, 3458, 3662], 'used': [731, 2403], 'prognostic': [738, 754, 1683, 2275], 'predictive,': [740], 'it': [742, 1302, 1583, 1648, 1729, 2124, 2144, 2151, 2417, 4018, 4110], 'important': [744, 3199, 3375, 3433], 'distinguish': [746], 'between': [747, 1187, 1227, 2082, 4116, 4226], 'two': [749, 2109, 3502, 4006], 'types': [750], 'biomarkers.': [752], 'associated': [757, 1894, 2475, 3065, 4429], 'how': [759, 2641, 3484, 3496], 'well': [760], 'will': [762, 774, 928, 964, 1319, 1912, 2349, 2391, 2614, 2766, 3197, 3215, 3431, 3468, 3867, 3901, 3936, 3969, 4026, 4043, 4062, 4071, 4081, 4322, 4356, 4384, 4392, 4405, 4409], 'given': [766], 'treatment.': [767, 799, 1332, 2591], 'predictive': [769, 803, 845, 1052, 1457, 2227, 2277, 2386, 2889, 2909, 2951, 3399, 3661, 4433], 'predicts': [771], 'what': [772], 'therapy': [773, 963, 1345, 1517, 1828, 1938, 1962, 2820, 3513, 3972, 3991, 4041, 4363, 4366], 'work': [775, 966], 'an': [778, 972, 1061, 1234, 1362, 1542, 1896, 2319, 2373, 2776, 2966, 3258, 3446, 3584, 3747, 3772, 3894, 4155, 4397], 'patient.': [780, 3998], 'Predictive': [781], 'tend': [783], 'useful': [787, 1468, 2705], 'because': [788, 1290, 2447], 'they': [789, 1676, 1697, 4076], 'improve': [791, 3179], 'outcomes': [792, 1901, 1978, 4292], 'optimizing': [796], 'choice': [797], 'For': [800, 1000, 1090, 1357, 1572, 1927, 4346], 'single': [802, 2115], 'biomarker,': [804, 1765, 2921], 'there': [805, 1334, 1496, 1848, 2548, 3444, 3490, 3652, 4450], 'various': [807, 2148, 3240], 'considered.6Hoering': [813], 'Scholar,9Mandrekar': [837], 'SJ': [838], 'Sargent': [839], 'DJ': [840], 'Clinical': [841, 897, 1130, 2195, 2998], 'validation:': [847], 'theoretical': [848], 'considerations': [849, 2222], 'practical': [851, 2221], 'challenges.J': [852], '27:': [856], '4027-4034Crossref': [857], '(327)': [860], 'Scholar,': [862, 886, 2985, 3019, 3041, 3089, 3113], '10Freidlin': [863], 'B': [864, 933, 1252, 1475, 1725, 1743, 1855, 2210], 'McShane': [865, 2217], 'LM': [866, 2218], 'Korn': [867, 934, 2211], 'EL': [868, 935, 1723, 1741, 1853, 2212], 'Randomized': [869], 'design': [874, 910, 941, 974, 980, 1057, 1286, 1364, 1368, 1386, 1634, 2579, 3852], 'issues.J': [875], '102:': [880], '152-160Crossref': [881], '(276)': [884], '11George': [887], 'SL': [888], 'Wang': [889, 3124], 'XHarrington': [890], 'D': [891, 1250], 'Targeted': [892], 'trials.': [894, 3389, 3477, 3695, 4269], 'Designs': [895], 'Trials:': [898], 'Perspectives': [899], 'Current': [901], 'Issues.': [902], 'Springer,': [903], '2012:': [904], '157-177Google': [905], 'appropriate': [908, 3447, 3716], 'analysis': [912, 1611, 2242, 2294], 'strategy': [913, 1183, 1285, 1635], 'should': [914, 1883, 1892, 2105, 2413, 2435, 2691, 2696, 2709, 2714, 3231, 3526, 3541, 4077], 'depend': [915, 1913], 'preexisting': [918], 'evidence': [919, 2530, 2551, 3654, 4453, 4504], 'successfully': [924], 'who': [927, 991, 1958, 2895, 3418, 4038], 'benefit': [929, 2830, 2877, 3370, 3640, 4519], 'treatment.12Freidlin': [932], 'Biomarker': [936, 2689], 'enrichment': [937, 973, 1363], 'strategies:': [938], 'matching': [939], 'credentials.Nat': [944], 'Rev': [945], '2014;': [948, 2781], '11:': [949], '81-90Crossref': [950], '(125)': [953], 'If': [956, 1044, 3926, 4075], 'one': [957, 1045, 1338, 1343, 1359, 2131, 3731], 'confident': [959, 1048], 'biomarker-negative': [969, 1087, 2307, 2411, 3441], 'population,': [970], 'then': [971, 1054], '(also': [975, 1058], 'known': [976, 1059, 2393], 'as': [977, 1060, 1329, 1370, 1809, 1833, 1860, 2003, 2158, 2354, 2404, 2438, 2445, 3130, 3305, 3515, 3583, 3681, 3886, 4154, 4207, 4475], 'marker-positive': [983], 'design),': [984], 'which': [985, 1065, 1222, 1444, 2659], 'only': [986, 3792, 4485], 'enrolls': [987], 'randomizes': [989, 1185], 'positive': [993], 'used.': [999, 1072], 'example,': [1001, 1091, 1358, 1502, 1928], 'crizotinib': [1002, 3745, 3956, 4015], 'was': [1003, 1110, 2812, 3556, 3611, 3705, 3778, 3817, 4152, 4169, 4205], 'tested': [1004, 1459, 2903], 'versus': [1005, 1026, 1397, 3128, 3505, 3963, 4010, 4016, 4400], 'standard': [1006, 3274, 3961, 3964, 4365, 4401], 'chemotherapy': [1007, 1027, 3129, 3517], 'alteration': [1012], 'anaplastic': [1014], 'lymphoma': [1015], 'kinase': [1016], '(ALK)': [1017], 'gene.13Shaw': [1018], 'AT': [1019], 'Kim': [1020], 'DW': [1021], 'Nakagawa': [1022], 'K': [1023], 'al.Crizotinib': [1025], 'ALK-positive': [1030, 3722], 'cancer.N': [1032, 1140, 2852, 3008], 'Engl': [1033, 1141, 2853, 3009, 3103], '2013;': [1036, 2232], '368:': [1037], '2385-2394Crossref': [1038], '(2838)': [1041], 'less': [1047], "biomarker's": [1051], 'ability,': [1053], 'biomarker-stratified': [1056, 1367], 'all-comers': [1062, 1169], 'design)': [1063], 'all': [1066, 1308, 2487], 'randomized': [1069, 1175, 1226, 1390, 1864], 'With': [1073, 1434], 'design,': [1075, 1180, 1184], 'treatment': [1077, 1159, 1190, 1193, 1295, 1317, 1383, 1401, 1619, 1645, 2444, 2624, 2636, 3132, 3248, 3266, 3487, 3588, 3962, 3965, 4276, 4304], 'effect': [1078, 1157], 'assessed': [1081], 'both': [1083, 1294, 2588, 2634, 4144], 'biomarker-positive': [1085, 2305, 2409], 'populations.': [1089], 'BR.21': [1094], 'examined': [1095], 'epidermal': [1096, 1414, 2970, 3060], 'growth': [1097, 1415, 2971, 3025, 3061], 'factor': [1098, 1416, 2972, 3026, 3062], 'receptor': [1099, 1417, 2973, 3027, 3063], '(EGFR)': [1100], 'expression': [1101], 'status': [1102, 2395, 2400], '(in': [1103], 'whom': [1107], 'tumor': [1108, 3202, 3237, 3295, 3303, 4087], 'available)': [1111], 'effectiveness': [1114], 'erlotinib': [1116, 1396, 3770, 3948, 4009], 'NSCLC.14Shepherd': [1118], 'FA': [1119, 2987], 'Rodrigues': [1120, 2988], 'Pereira': [1121, 2989], 'Ciuleanu': [1123, 2991], 'T': [1124, 2992], 'Canada': [1129, 2997], 'Trials': [1131, 2999], 'Group': [1132, 1220, 3000], 'al.Erlotinib': [1134, 3002, 3127], '353:': [1145, 3013], '123-132Crossref': [1146, 3014], '(3677)': [1149], 'One': [1152], 'also': [1154, 3350, 4490], 'examine': [1155], 'overall': [1160, 1799], 'taking': [1162], 'account': [1164], 'design;': [1170], 'design.': [1177], 'third': [1179], 'control': [1189, 1229, 1590], 'chosen': [1196], 'basis': [1202], 'his': [1204], 'her': [1206], 'status.': [1208], 'An': [1209, 2176, 3696], 'example': [1210, 4156], 'Spanish': [1217], 'arm': [1230, 1236, 1318, 1591, 4390], 'docetaxel/cisplatin': [1232, 1239], 'experimental': [1235, 1316], 'either': [1238], 'docetaxel/gemcitabine': [1241], 'their': [1244, 1456, 1919, 2507, 3932, 4069, 4086], 'ERCC1': [1245], 'mRNA': [1246, 1263], 'levels.15Cobo': [1247], 'Isla': [1249], 'Massuti': [1251], 'al.Customizing': [1254], 'cisplatin': [1255], 'quantitative': [1258], 'excision': [1259], 'repair': [1260], 'cross-complementing': [1261], '1': [1262], 'expression:': [1264], '2007;': [1275], '25:': [1276], '2747-2754Crossref': [1277], '(436)': [1280], 'inefficient': [1289], 'many': [1291, 1321, 2075], 'arms': [1296, 1620, 3841, 4007], 'receive': [1298, 1320, 3970], 'same': [1300, 1328], 'treatment;': [1301], 'generally': [1304], 'recommended': [1306], 'unless': [1307, 3978], '(or': [1309, 1438], 'almost': [1310], 'all)': [1311], 'different': [1322, 1633, 2741, 4195], 'treatments': [1323], 'control-arm': [1331], 'When': [1333, 1495], 'interest,': [1347], 'analyses': [1352, 1564], 'become': [1354], 'complicated.': [1356], 'combine': [1361, 3823], 'TAILOR': [1373], 'trial.16Farina': [1374], 'G': [1375, 3119], 'Longo': [1376], 'Martelli': [1378], 'O': [1379], 'al.Rationale': [1381], 'tailor:': [1388], 'second-line': [1395, 4303], 'docetaxel': [1398], 'affected': [1404], 'absence': [1412, 2382, 2917], 'mutations.Clin': [1418], 'Cancer.': [1420], '2011;': [1421, 1522, 1733, 1752, 1873, 3153], '12:': [1422, 3083, 3154], '138-141Abstract': [1423], '(10)': [1431], 'multiple': [1435, 1498, 1825, 2153, 2730, 2756], 'possible': [1436, 2446, 2467], 'high-dimensional': [1439], 'genomic': [1440, 4096], 'data),': [1441], 'cross-validation': [1442], 'combinations': [1445, 4372], 'developed': [1449], 'ability': [1458], 'other': [1461, 2866, 4416], 'guard': [1470], 'against': [1471, 4426], 'overfitting': [1472], 'data.17Freidlin': [1474], 'Jiang': [1476], 'Simon': [1478], 'cross-validated': [1481], 'adaptive': [1482, 1543, 3697], 'signature': [1483], 'design.Clin': [1484], '16:': [1488], '691-698Crossref': [1489], '(155)': [1492], 'treatments,': [1500], 'BATTLE-1': [1505], 'trial18Kim': [1506], 'ES': [1507], 'Herbst': [1508, 2958], 'RS': [1509], 'Wistuba': [1510], 'II': [1511, 3877, 4441], 'al.The': [1513], 'BATTLE': [1514, 3253], 'trial:': [1515], 'personalizing': [1516], 'cancer.Cancer': [1520, 3035], 'Discov.': [1521], '1:': [1523], '44-53Crossref': [1524], '(684)': [1527], 'I-SPY2': [1532], 'trial,19Barker': [1533], 'AD': [1534], 'Sigman': [1535], 'CC': [1536], 'Kelloff': [1537], 'GJ': [1538], 'al.I-SPY': [1540], '2:': [1541], 'breast': [1544, 4166], 'setting': [1549, 1966], 'neoadjuvant': [1551], 'chemotherapy.Clin': [1552], 'Pharm': [1553], 'Therap.': [1554], '86:': [1556], '97-100Crossref': [1557], '(531)': [1560], 'considered': [1570], 'exploratory.': [1571], 'lead': [1579, 1699, 4264], 'registration,': [1582], 'critical': [1585, 1845, 2623, 4112], 'have': [1587, 1607, 1829, 2001, 2392, 2697, 2873, 2906, 4422], 'matched': [1589], 'substudy': [1594, 4404, 4445, 4463], 'permit': [1596], 'comparative': [1597], 'assessment': [1598, 1840, 3573], 'efficacy': [1600, 1779, 3182, 4507], 'toxicity.': [1602], 'It': [1603, 3196, 3430, 3777], 'desirable': [1605], 'interim': [1608, 1708], 'monitoring': [1609, 1709, 2661], 'plans': [1612], 'incorporated': [1613], 'promising': [1624, 2553, 2920, 3438], 'dropped': [1627], 'early.': [1628], 'Outcome-adaptive': [1629, 1726], 'randomization': [1630, 1672, 2397], 'aims': [1637], 'put': [1639], 'better': [1643], 'performing': [1644], 'arms.': [1646], 'However,': [1647, 2461, 2864], 'complex': [1650, 4244], 'implement': [1652], 'requires': [1654, 2181, 2243, 2369], 'meaningful': [1656, 1909, 4492], 'short-term': [1657], 'end': [1659, 1769, 1780, 1812, 1837, 2154, 3634, 3682, 3748, 3773, 3889, 4477], 'point': [1660, 1781, 3749, 3774, 3890, 4478], 'fast': [1663], 'turnaround': [1664, 2701], 'assays.': [1667, 4345], 'Potential': [1668], 'disadvantages': [1669], 'outcome-adaptive': [1671, 1748], 'produce': [1678], 'biased': [1679], 'if': [1681, 2123, 2416, 3548], 'characteristics': [1684, 3547], 'entering': [1687], 'change': [1690, 2048], 'over': [1691, 2317, 2459], 'period': [1693], 'accrual,': [1695], 'larger': [1702], 'total': [1703], 'size': [1705], 'simpler': [1707], 'methods,': [1710], 'potentially': [1711], 'greater': [1715], 'absolute': [1716], 'number': [1717, 2141, 3479, 3783], 'having': [1720], 'bad': [1721], 'outcomes.20Korn': [1722], 'Freidlin': [1724, 1742, 1854, 2209], 'randomization:': [1727], 'Is': [1728, 3624, 3651], 'useful?.J': [1730], '29:': [1734, 1753, 1874], '771-776Crossref': [1735], '(146)': [1738], 'Scholar,21Korn': [1740], 'usefulness': [1746], 'randomization.J': [1749], 'e393Crossref': [1754], '(13)': [1756], 'Regardless': [1759], 'incorporation': [1762], 'need': [1768, 2520, 2584, 3176, 3271, 3787], 'points': [1770, 2155, 3242, 3635], 'relevant': [1771, 4255], 'questions': [1774, 3617], 'being': [1775, 2744], 'asked.': [1776], 'Traditionally,': [1777], '(FDA)': [1790], 'survival': [1800, 1804, 1859, 2829, 3068, 3752, 4047], '(OS),': [1801], 'but': [1802, 3791, 4246, 4489], 'progression-free': [1803], '(PFS)': [1805], 'gaining': [1807], 'importance': [1808, 3224], 'primary': [1811, 3888, 4436, 4476], 'point.': [1813, 1838], 'growing': [1815], 'popularity': [1816], 'crossover': [1818, 2557], 'increasing': [1822], 'availability': [1823, 2296, 2723], 'lines': [1826], 'largely': [1830], 'undermined': [1831], 'OS': [1832, 1842, 2163, 3885], 'sole': [1835], 'definitive': [1836], 'Nonetheless,': [1839], 'still': [1844, 2350], 'even': [1846], 'when': [1847, 2547, 3489, 3618], 'effective': [1850, 1868], 'subsequent': [1851, 1869, 2017], 'therapies.22Korn': [1852], 'Abrams': [1856, 2215], 'JS': [1857, 2216], 'Overall': [1858], 'therapies.J': [1870], '2439-2442Crossref': [1875], '(97)': [1878], 'PFS': [1881, 4474], 'statistically': [1885, 2173, 4487], 'significant': [1886, 4488], 'clinically': [1888, 1908, 2171, 4491], 'meaningful,': [1889], 'ideally': [1891, 2713], 'reported': [1900, 1977], 'Quality': [1903, 1980], 'Life.': [1905], 'What': [1906], 'stage': [1917, 1933, 4202], 'toxicity': [1923, 1954, 3575], 'drug.': [1926], 'receiving': [1936, 1960], 'adjuvant': [1937, 3694, 3725, 3941], 'intention': [1940, 4133], 'cure': [1944, 1968], 'willing': [1947], 'accept': [1949], 'higher': [1951], 'level': [1952], 'metastatic': [1965], 'where': [1967, 2130], 'possible.': [1971], 'There': [1972, 2026, 3268, 3555, 4168], 'no': [1974], 'FDA-approved': [1975, 3919], 'Life': [1982], 'tools': [1983, 1994], 'validation': [1991], 'urgently': [1996], 'needed.': [1997], 'Many': [1998], 'arisen': [2002], 'result': [2005, 3527], 'increased': [2007], 'knowledge': [2008, 3218], 'aberrations': [2012], 'abnormalities.': [2025], 'tendency': [2030], 'drug': [2032, 2193, 2569, 2800, 2944], 'developers': [2033], 'investigators': [2035, 2565], 'overly': [2037], 'strict': [2038], 'interpretation': [2039], 'regulations': [2042, 2101], 'general': [2045, 3557], 'reluctance': [2046], 'current': [2049, 2748, 3851], 'practice': [2050], 'fear': [2052], 'adverse': [2054], 'consequences.': [2056], 'submitted': [2059], 'sometimes': [2060], 'require': [2061, 2497, 2767, 3293], 'excessive': [2062], 'collection': [2064], 'poorly': [2068], '(e.g.,': [2070], 'too': [2071, 2074], 'complicated': [2072, 2581], 'objectives).': [2076], 'Earlier': [2077], 'continuous': [2080], 'engagement': [2081], 'authorities': [2084], 'pharmaceutical': [2086, 4117, 4236], 'partners': [2090], 'crucial': [2092], 'developing': [2098, 2515, 3226, 4242], 'field.': [2099], 'FDA': [2100, 2122, 2765, 2771, 2816, 4510], 'state': [2102], 'adequate': [2110, 2245, 2298, 3638, 3653], 'well-controlled': [2112], 'studies.': [2113], 'acceptable': [2119], 'large': [2127, 2924, 3782], 'multicenter': [2128], 'few': [2134], 'institutions': [2135], 'did': [2136], 'contribute': [2138], 'disproportionate': [2140], 'patients,': [2143, 3442, 4035], 'consistency': [2146], 'among': [2147, 4185], 'subsets,': [2149], 'evaluated': [2156], 'response': [2159, 3679], 'rate,': [2160], 'PFS,': [2161], 'robust': [2169], 'persuasive': [2174], 'outcomes.': [2175], 'drug/device': [2178], 'co-development': [2179], 'plan': [2180], 'simultaneous': [2182], 'assay': [2186, 2333, 2427, 2628, 2657, 2677, 3912], 'methodology': [2187], 'determine': [2192, 2421, 4093], 'efficacy.': [2194], 'come': [2201], 'retrospective': [2203, 2293, 2355, 2364], 'prospective': [2205, 2321, 2367], 'trials.23Polley': [2207], 'MY': [2208], 'Conley': [2213], 'BA': [2214], 'Statistical': [2219], 'evaluation': [2225, 2273, 2595, 3309], 'biomarkers.J': [2228, 2278], '105:': [2233], '1677-1683Crossref': [2234], '(103)': [2237], 'Retrospective': [2240], 'collected': [2249], 'most': [2251, 4209], 'analyzed': [2257], 'according': [2258], 'prespecified': [2261, 4482], 'plan.24Simon': [2262], 'RM': [2263], 'Paik': [2264], 'S': [2265, 3095], 'Hayes': [2266], 'Use': [2268], 'archived': [2270, 3294], '101:': [2283], '1446-1452Crossref': [2284], '(807)': [2287], 'advantages': [2291], 'include': [2295, 2324, 2510, 3454, 3572], 'follow-up,': [2299], 'inclusion': [2301], 'cancers': [2308, 3403], 'set,': [2312], 'cost': [2315, 2474], 'savings': [2316], 'conducting': [2318, 2922], 'additional': [2320], 'trial.': [2322], 'Disadvantages': [2323], 'multiplicity': [2325], 'issues': [2326, 3376], 'selection': [2329, 3396], 'and,': [2330], 'depending': [2331], 'requirements,': [2334], 'possibility': [2336, 3451], 'inadequate': [2338], 'specimen': [2339, 2639, 2643, 3277, 3344], 'collection,': [2340], 'handling,': [2341], 'storage.': [2343], 'In': [2344, 2361, 2545, 2803, 3325, 3893, 3999, 4187, 4318], 'addition,': [2345, 2546], 'confirmatory': [2347], 'needed': [2353, 2726, 4028, 4219], 'often': [2359, 2483, 3333, 3409], 'incomplete.': [2360], 'contrast': [2362], 'analyses,': [2365], 'presence': [2380], 'specific': [2385, 4328, 4382], 'biomarker.': [2387], 'All': [2388, 4034], 'before': [2396, 2486], 'stratification': [2406], 'variable.': [2407], 'Both': [2408], 'enrolled': [2415, 3385, 3802], 'desired': [2419], 'whether': [2422, 4449], 'its': [2426, 2604], 'truly': [2429], 'predictive.': [2430], 'Ideally,': [2431], 'obtained': [2437], 'close': [2439, 4412], 'time': [2442, 2702, 2734, 3241, 3603, 4091, 4216], "patient's": [2449], 'develop': [2452, 2751], 'competitive': [2454], 'advantage': [2455], 'and/or': [2456, 3518], 'resistance': [2457, 3220], 'mutations': [2458, 3028, 3058, 3767, 3906], 'time.': [2460], 'always': [2466], 'due': [2468], 'morbidities': [2471], 'biopsies.': [2477], 'As': [2478, 3166, 3222, 3390], 'might': [2479], 'expected,': [2481], 'runs': [2484], 'out': [2485], 'planned': [2489], 'later': [2490], 'performed': [2494], 'prioritization.': [2499], 'Pharmaceutical': [2500], 'discussed': [2506, 3706], 'challenges.': [2508], 'These': [2509], 'global': [2512], 'burden': [2513], 'drugs,': [2516], 'establishing': [2517], 'unmet': [2518], 'medical': [2519], 'newly': [2523], 'group,': [2526], 'differences': [2527], 'required': [2531], 'US': [2533], 'EU': [2535], 'accelerated/conditional': [2536], 'approval,': [2537], 'companion': [2542, 2774, 2805], 'preliminary': [2550], 'efficacy,': [2554], 'allowing': [2556], 'found': [2560], 'unacceptable': [2563], 'patients.': [2567, 2719, 4294, 4520], 'Biomarker-targeted': [2568], 'presents': [2571], 'opportunities': [2572], '"personalized': [2574], 'medicine,"': [2575], 'although': [2576], 'address': [2586], 'simultaneously': [2587], 'Well-planned': [2592], 'device': [2599], 'essential': [2601], 'understanding': [2603], 'value': [2605], 'guiding': [2607], 'therapeutic': [2611, 2876, 4370], 'product.': [2612], 'Clinicians': [2613], 'rely': [2615], 'test': [2618, 2728, 3712, 4221], 'information': [2619], 'help': [2621], 'make': [2622], 'decisions.': [2625], 'system': [2631], 'includes': [2633, 2660], 'preanalytical': [2635], '(i.e.,': [2640], 'obtained,': [2645], 'stored,': [2646], 'shipped,': [2647], 'preprocessed': [2649], 'assay)': [2652], 'itself,': [2658], 'quality': [2663], 'reproducibility': [2665], 'methods': [2668], 'capture,': [2671], 'assessment,': [2672], 'reporting.': [2674], 'must': [2678, 4421], 'demonstrated': [2680, 2875, 2908, 4423], 'perform': [2682], 'reproducibly': [2683], 'intended': [2686], 'environment.': [2688], 'testing': [2690, 2740, 3437, 3834], 'standardized': [2693], 'reproducible,': [2695], 'quick': [2699], 'enough': [2700], 'decision-making,': [2708], 'cost-effective,': [2711], 'involve': [2715], 'little': [2716], 'risk': [2717], 'Concerns': [2720], 'regarding': [2721, 3219, 3559], 'lost': [2735], 'treat': [2737], 'while': [2739], 'addressed': [2745], 'effort': [2749, 4160, 4218, 4248], 'multiplex': [2752], 'interrogate': [2755], 'signaling': [2757], 'pathways.': [2758, 3221], 'Approval': [2759], 'proper': [2768], 'validation.25Mansfield': [2769], 'EA': [2770], 'diagnostics:': [2775], 'paradigm.Clin': [2778], '20:': [2782], '1453-1457Crossref': [2783], '(47)': [2786], 'Scholar,26U.S.': [2788], 'Draft': [2793], 'guidance': [2794, 3372], 'food': [2798], 'administration': [2801], 'staff.': [2802], 'devices.Available': [2807], 'at:': [2808], 'http://www.fda.gov/downloads/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/UCM262327.pdfGoogle': [2809], 'Bevacizumab': [2811], 'approved': [2813], 'first-line': [2819, 3131], 'nonsquamous': [2823], 'modest': [2828], 'noted': [2831, 3779], 'E4599.27Sandler': [2837], 'Gray': [2839], 'Perry': [2841], 'MC': [2842], 'al.Paclitaxel-carboplatin': [2844], 'alone': [2845], 'bevacizumab': [2848], '2006;': [2856, 3082], '355:': [2857], '2542-2550Crossref': [2858], '(5232)': [2861], 'several': [2865], 'angiogenic': [2871], 'pathway': [2872], 'NSCLC.': [2879], 'main': [2881, 3173], 'problem': [2882], 'lack': [2886, 4059, 4380], 'could': [2892, 3260, 4249, 4272], 'stand': [2896], 'benefit.': [2898], 'None': [2899], 'date': [2905, 4053], 'consistently': [2907], 'potential.': [2910], 'panel': [2912, 3363, 3521, 3610, 4342], 'concluded': [2913], 'further': [2923], 'anti-angiogenic': [2927], 'warranted.': [2933], 'EGFR': [2937, 3137, 3168, 3208, 3766, 3905, 3951], 'inhibitors': [2938, 3169, 3209], 'represents': [2939, 3314], 'remarkable': [2941], 'tale': [2942], 'followed': [2946, 4045], 'biomarker.28Kris': [2952], 'G,': [2954], 'Natale': [2955], 'B,': [2957], 'S,': [2960], 'Efficacy': [2963], 'gefitinib,': [2965], 'inhibitor': [2967], 'tyrosine': [2974], 'kinase,': [2975], 'symptomatic': [2977], 'non-small': [2980, 3032, 3070], 'cell': [2981, 3033, 3071], 'JAMA.;290:2149–2158Google': [2984], '29Shepherd': [2986], '(5088)': [3017], '30Johnson': [3020], 'BE': [3021], 'Jänne': [3022], 'PA': [3023], 'Epidermal': [3024], '65:': [3038], '7525-7529PubMed': [3039], '31Jackman': [3042], 'DM': [3043], 'Yeap': [3044], 'BY': [3045], 'Sequist': [3046], 'LV': [3047], 'Lindeman': [3048], 'Holmes': [3050], 'AJ': [3051], 'Joshi': [3052], 'VA': [3053], 'al.Exon': [3055], '19': [3056], 'deletion': [3057], 'prolonged': [3067], 'gefitinib': [3077], 'erlotinib.Clin': [3079], '3908-3914Crossref': [3084], '(519)': [3087], '32Mok': [3090], 'TS': [3091], 'Wu': [3092, 3116], 'YL': [3093, 3117], 'Thongprasert': [3094], 'carboplatin-paclitaxel': [3099], 'pulmonary': [3101], 'adenocarcinoma.N': [3102], '361:': [3107], '947-957Crossref': [3108], '(7034)': [3111], '33Zhou': [3114], 'C': [3115, 3125], 'Chen': [3118], 'Feng': [3120], 'Liu': [3122], 'XQ': [3123], 'mutation-positive': [3138], '(OPTIMAL,': [3142], 'CTONG-': [3143], '0802):': [3144], 'multicenter,': [3146], 'open-label,': [3147], 'randomized,': [3148], '3': [3150], 'study.Lancet': [3151], '735-742Abstract': [3155], '(3403)': [3163], 'developed,': [3171], 'areas': [3174], 'upon': [3180, 3545], 'existing': [3184], 'agents,': [3185, 3494], 'delay': [3187], 'emergence': [3189], 'resistance,': [3191], 'resistance.': [3195], 'obtain': [3201, 3284], 'tissues': [3203], 'studies': [3213, 3942], 'enhance': [3216, 3469, 4114, 4141], 'our': [3217], 'clear,': [3229], 'physicians': [3230], 'open': [3233, 4410], 'obtaining': [3235], 'biopsy': [3238], 'during': [3243], 'course': [3245], 'showed': [3255], 'approach': [3259, 4271], 'aid': [3261], 'individualized': [3265], 'approaches.': [3267], 'adopt': [3273], 'practices': [3275, 3348], 'preparation': [3278], 'storage': [3280, 3347], 'order': [3282, 3378, 4000, 4516], 'maximal': [3285], 'yield': [3286], 'biopsy.': [3289], 'Increasingly,': [3290], 'some': [3299], 'instances,': [3300], 'fresh': [3301], 'frozen': [3302], 'tissue,': [3304], 'part': [3306], 'agents.': [3312, 3429, 4223], 'challenge': [3316], 'through': [3321], 'community': [3322, 3360, 3366, 4231], 'practices.': [3324], 'addition': [3326, 3507, 3946], 'logistical': [3328], 'procedures': [3331], 'compensated': [3335], 'adequately': [3336], 'sponsor': [3340], 'payers.': [3342], 'Standardized': [3343], 'acquisition': [3345], 'necessary': [3351], 'ensure': [3353], 'submission': [3354], 'high-quality': [3356], 'setting.': [3361], 'agreed': [3364, 3522, 4108], 'sites': [3367], 'would': [3368, 3711, 3786, 3800], 'greatly': [3369], 'increase': [3380], 'proportion': [3382], 'move': [3393], 'biomarkers,': [3400], 'excluded.': [3410], 'causes': [3412], 'anxiety': [3413], 'disappointment': [3415], 'unable': [3420], 'participate': [3422], 'exciting': [3427], 'allow': [3435], 'drugs': [3439, 4281, 4420], 'provided': [3443], 'rationale.': [3449], 'Another': [3450], 'without': [3456], 'concurrent': [3461], 'non-targeted': [3465], 'agent.': [3466], 'enthusiasm': [3471], 'participation': [3473, 4174], 'controversies': [3481], 'remain': [3482], 'including': [3483, 4036], 'prioritize': [3486], 'arms,': [3488], 'multiple,': [3492], 'select': [3498], 'combination': [3500, 3684, 4334], 'conventional': [3512], 'cytotoxic': [3516], 'radiotherapy.': [3519], 'future': [3524, 3567], 'proposals': [3525], 'shift,': [3531], 'biologically': [3533], 'innovative': [3536], 'selected': [3543, 3666], 'occur.': [3554], 'agreement': [3558], 'desire': [3561], 'integrate': [3563], 'validated': [3564], 'designs,': [3570], 'conjunction': [3577], 'pharmacogenomics,': [3579], 'validate': [3581], 'imaging': [3582], 'indicator': [3586], 'effectiveness,': [3589], 'serial': [3596], 'biopsies': [3597], 'whenever': [3598], 'possible,': [3599], 'particularly': [3600], 'radiographic': [3607], 'progression.': [3608], 'asked': [3612], 'consider': [3614], 'three': [3615], 'overriding': [3616], 'evaluating': [3619], 'proposal': [3621, 3626, 3710], 'presented:': [3622], '(1)': [3623], 'feasible?': [3629], '(2)': [3630], 'Are': [3631], 'indicative': [3636], 'statistical': [3644], 'underpinnings': [3645], 'robust?': [3649], '(3)': [3650], 'support': [3656, 4509], 'appropriately': [3668], 'validated?': [3669], 'Concepts': [3670], 'presented': [3671], 'included': [3672], 'first-in-man': [3673], 'targets': [3674], 'studied': [3677], 'rate': [3680], 'point,': [3683], 'chemo/radiation': [3685], 'locally': [3688], 'cancers,': [3691], 'target-based': [3693], 'regionally': [3702], 'RTOG.': [3708], 'chemoradiation': [3713], 'following': [3714], 'molecular-targeted': [3717], '(EGFR': [3719], 'mutated': [3720], 'patients).': [3723], 'Two': [3724], '(stages': [3727], 'I–III)': [3728], 'discussed,': [3730], 'proposed': [3732, 3758, 4432], 'ECOG': [3734], '(Now': [3735], 'ECOG-ACRIN)': [3736], 'ALK': [3740, 3914, 3958], 'gene': [3741], 'rearrangements': [3742], 'disease-free': [3751], '(DFS)': [3753], 'similar': [3756], 'CALGB': [3760], '(now': [3761], 'Alliance)': [3762], 'OS.': [3776], 'screened,': [3790], '5%': [3794], '15%': [3796], 'screened': [3798, 3812, 3903, 4324], 'making': [3806], 'upwards': [3807], '85%': [3809], 'irrelevant.': [3814], 'call': [3816], 'made': [3818, 4083], 'attendees': [3821, 4107], 'efforts': [3825], 'employ': [3827], 'common': [3829], 'screening': [3830, 3896, 4032], 'step': [3831], 'central': [3833], 'provision': [3837], 'add': [3839], 'future.': [3843], 'discussion': [3848], 'ALCHEMIST': [3854, 3865], '(Adjuvant': [3855], 'Enrichment': [3858], 'Marker': [3859], 'Identification': [3860], 'Sequencing': [3862], 'Trial).': [3863], 'enroll': [3868, 4002, 4030, 4063], 'resectable': [3871], '(stage': [3872], 'IB': [3873], '≥': [3874], '4': [3875], 'cm,': [3876], 'IIIA)': [3879], 'adenocarcinoma': [3880], 'lung,': [3883], '(Figure': [3891, 4493], '1).': [3892], 'umbrella': [3895], 'protocol': [3897, 3971, 4040], 'A151216,': [3898], 'using': [3907, 3917], 'polymerase': [3909], 'chain': [3910], 'reaction-based': [3911], 'fusion': [3915], 'break-apart': [3920], 'fluorescence': [3921], 'situ': [3923], 'hybridization': [3924], 'assay.': [3925], 'genetic': [3927], 'detected': [3930], 'tumors,': [3933], 'eligible': [3938], 'separate': [3940], 'A081105': [3943], 'comparing': [3944, 4465], '(for': [3949, 3957], 'activating': [3950], 'mutations)': [3952], 'E4512': [3954], 'adding': [3955], 'fusions)': [3959], 'after': [3960], 'placebo.': [3967], 'Patients': [3968, 4056, 4377], 'up': [3974], '2': [3976], 'years': [3977, 4050], 'unresolved': [3981], 'toxicities,': [3982], 'withdrawal': [3984], 'physician': [3986], 'decides': [3987], 'stop': [3989], 'interest': [3995], '410': [4003], 'placebo': [4011], '300': [4013], 'Placebo,': [4017], 'estimated': [4020], 'about6000': [4022], '8000': [4024], 'protocol.': [4033], 'discontinue': [4039], 'early,': [4042], '10': [4049], 'registration.': [4055], 'whose': [4057, 4378], 'registry': [4066], 'undergo': [4072], 'whole-exome': [4073], 'sequencing.': [4074], 'relapse,': [4078], 'every': [4079], 'attempt': [4080], 're-sequence': [4085], 'natural': [4095], 'history': [4097], 'cancers.': [4100], 'To': [4101], 'accelerate': [4102], 'trials,': [4106], 'coordination': [4115], 'developers,': [4118], 'FDA,': [4119, 4228], 'academic': [4120, 4147], 'community-based': [4122], 'investigators,': [4124], '(NCI),': [4128], 'decrease': [4135], 'red': [4136], 'tape,': [4137], 'reduce': [4138], 'competition,': [4139], 'cooperation': [4142], 'across': [4143], 'commercial': [4145], 'organizations.': [4150], 'I-SPY': [4151], 'cited': [4153], 'collaborative': [4159], 'currently': [4161], 'ongoing': [4162], 'reward': [4173], 'teamwork': [4176], 'create': [4179], 'mechanism': [4181], 'eliminate': [4183], 'competition': [4184], 'investigators.': [4186], 'conclusion,': [4188], '"Master': [4192, 4297], 'stages': [4196], '(adjuvant,': [4200], 'neoadjuvant,': [4201], 'III,': [4203], 'advanced/metastatic)': [4204], 'identified': [4206, 4331], 'expeditious': [4210], 'way': [4211], 'cut': [4213], 'down': [4214], 'Extensive': [4224], 'collaboration': [4225], 'NCI,': [4229], 'academia,': [4230], 'programs,': [4233], 'key': [4240], 'rewarded': [4251], 'scientifically': [4254], 'attractive': [4259], 'thus': [4263], 'completed': [4268], 'revolutionize': [4273], 'bringing': [4278], 'forward': [4279], 'much': [4282], 'eventually': [4288], 'improved': [4291], 'Protocol"': [4298], 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