Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2035008865', 'doi': 'https://doi.org/10.1155/2011/195239', 'title': 'Protein Tyrosine Phosphatase SHP-2 (<i>PTPN11</i>) in Hematopoiesis and Leukemogenesis', 'display_name': 'Protein Tyrosine Phosphatase SHP-2 (<i>PTPN11</i>) in Hematopoiesis and Leukemogenesis', 'publication_year': 2011, 'publication_date': '2011-06-07', 'ids': {'openalex': 'https://openalex.org/W2035008865', 'doi': 'https://doi.org/10.1155/2011/195239', 'mag': '2035008865', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21799948', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3135119'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2011/195239', 'pdf_url': 'https://downloads.hindawi.com/archive/2011/195239.pdf', 'source': {'id': 'https://openalex.org/S113543207', 'display_name': 'Journal of Signal Transduction', 'issn_l': '2090-1747', 'issn': ['2090-1747', '2090-1739'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://downloads.hindawi.com/archive/2011/195239.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049779153', 'display_name': 'Xia Liu', 'orcid': 'https://orcid.org/0000-0002-3110-9602'}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xia Liu', 'raw_affiliation_strings': ['Division of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.', 'institution_ids': ['https://openalex.org/I58956616']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085618254', 'display_name': 'Cheng‐Kui Qu', 'orcid': 'https://orcid.org/0000-0002-4256-8652'}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cheng-Kui Qu', 'raw_affiliation_strings': ['Division of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.', 'institution_ids': ['https://openalex.org/I58956616']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.814, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.903491, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '2011', 'issue': None, 'first_page': '1', 'last_page': '8'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12104', 'display_name': 'Protein Tyrosine Phosphatases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12104', 'display_name': 'Protein Tyrosine Phosphatases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12387', 'display_name': 'Galectins and Cancer Biology', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9782, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ptpn11', 'display_name': 'PTPN11', 'score': 0.9834402}, {'id': 'https://openalex.org/keywords/noonan-syndrome', 'display_name': 'Noonan Syndrome', 'score': 0.88456476}, {'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.45706382}], 'concepts': [{'id': 'https://openalex.org/C31734879', 'wikidata': 'https://www.wikidata.org/wiki/Q14905494', 'display_name': 'PTPN11', 'level': 5, 'score': 0.9834402}, {'id': 'https://openalex.org/C2776149932', 'wikidata': 'https://www.wikidata.org/wiki/Q1543446', 'display_name': 'Noonan syndrome', 'level': 2, 'score': 0.88456476}, {'id': 'https://openalex.org/C85528070', 'wikidata': 'https://www.wikidata.org/wiki/Q643602', 'display_name': 'Protein tyrosine phosphatase', 'level': 3, 'score': 0.86238575}, {'id': 'https://openalex.org/C178666793', 'wikidata': 'https://www.wikidata.org/wiki/Q422476', 'display_name': 'Phosphatase', 'level': 3, 'score': 0.61245525}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5970521}, {'id': 'https://openalex.org/C109159458', 'wikidata': 'https://www.wikidata.org/wiki/Q919283', 'display_name': 'Haematopoiesis', 'level': 3, 'score': 0.58257985}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.48830247}, {'id': 'https://openalex.org/C109825262', 'wikidata': 'https://www.wikidata.org/wiki/Q1139164', 'display_name': 'Germline', 'level': 3, 'score': 0.48610497}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.4789108}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.45706382}, {'id': 'https://openalex.org/C13514818', 'wikidata': 'https://www.wikidata.org/wiki/Q5552256', 'display_name': 'Germline mutation', 'level': 4, 'score': 0.44832507}, {'id': 'https://openalex.org/C134305767', 'wikidata': 'https://www.wikidata.org/wiki/Q725508', 'display_name': 'Somatic cell', 'level': 3, 'score': 0.43759042}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.38969624}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3335632}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32347798}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.319241}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31235445}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.25572175}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19404888}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.16754308}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.15667409}, {'id': 'https://openalex.org/C2781187634', 'wikidata': 'https://www.wikidata.org/wiki/Q20969980', 'display_name': 'KRAS', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2011/195239', 'pdf_url': 'https://downloads.hindawi.com/archive/2011/195239.pdf', 'source': {'id': 'https://openalex.org/S113543207', 'display_name': 'Journal of Signal Transduction', 'issn_l': '2090-1747', 'issn': ['2090-1747', '2090-1739'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3135119', 'pdf_url': 'https://europepmc.org/articles/pmc3135119?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135119', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21799948', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2011/195239', 'pdf_url': 'https://downloads.hindawi.com/archive/2011/195239.pdf', 'source': {'id': 'https://openalex.org/S113543207', 'display_name': 'Journal of Signal Transduction', 'issn_l': '2090-1747', 'issn': ['2090-1747', '2090-1739'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.73}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'HL068212'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'HL095657'}], 'datasets': [], 'versions': [], 'referenced_works_count': 85, 'referenced_works': ['https://openalex.org/W1488372279', 'https://openalex.org/W1852704228', 'https://openalex.org/W1963604934', 'https://openalex.org/W1968472053', 'https://openalex.org/W1969821131', 'https://openalex.org/W1969918683', 'https://openalex.org/W1973053031', 'https://openalex.org/W1977803566', 'https://openalex.org/W1978571157', 'https://openalex.org/W1986755373', 'https://openalex.org/W1990092210', 'https://openalex.org/W1992865738', 'https://openalex.org/W1993948601', 'https://openalex.org/W1996274092', 'https://openalex.org/W1997508007', 'https://openalex.org/W1997662291', 'https://openalex.org/W2000417172', 'https://openalex.org/W2000813775', 'https://openalex.org/W2001591379', 'https://openalex.org/W2006147172', 'https://openalex.org/W2007832042', 'https://openalex.org/W2011126155', 'https://openalex.org/W2011653532', 'https://openalex.org/W2023763994', 'https://openalex.org/W2024837443', 'https://openalex.org/W2025803931', 'https://openalex.org/W2028135614', 'https://openalex.org/W2028517758', 'https://openalex.org/W2029723738', 'https://openalex.org/W2030886916', 'https://openalex.org/W2032861488', 'https://openalex.org/W2034549217', 'https://openalex.org/W2035273847', 'https://openalex.org/W2037777433', 'https://openalex.org/W2038106655', 'https://openalex.org/W2045979867', 'https://openalex.org/W2047132622', 'https://openalex.org/W2053899257', 'https://openalex.org/W2054769839', 'https://openalex.org/W2056461696', 'https://openalex.org/W2058597692', 'https://openalex.org/W2063582171', 'https://openalex.org/W2065632930', 'https://openalex.org/W2071486708', 'https://openalex.org/W2072037914', 'https://openalex.org/W2077210972', 'https://openalex.org/W2082289040', 'https://openalex.org/W2082448876', 'https://openalex.org/W2083800765', 'https://openalex.org/W2084440639', 'https://openalex.org/W2088044493', 'https://openalex.org/W2090695896', 'https://openalex.org/W2093762625', 'https://openalex.org/W2094548766', 'https://openalex.org/W2098997742', 'https://openalex.org/W2104140518', 'https://openalex.org/W2105125890', 'https://openalex.org/W2108447730', 'https://openalex.org/W2110763175', 'https://openalex.org/W2110950542', 'https://openalex.org/W2112410112', 'https://openalex.org/W2114990619', 'https://openalex.org/W2118719488', 'https://openalex.org/W2121750050', 'https://openalex.org/W2121948177', 'https://openalex.org/W2124171936', 'https://openalex.org/W2125042440', 'https://openalex.org/W2127227377', 'https://openalex.org/W2129595021', 'https://openalex.org/W2129792506', 'https://openalex.org/W2130526419', 'https://openalex.org/W2130708019', 'https://openalex.org/W2132298090', 'https://openalex.org/W2144844081', 'https://openalex.org/W2145937691', 'https://openalex.org/W2148006813', 'https://openalex.org/W2152611311', 'https://openalex.org/W2169523531', 'https://openalex.org/W2171383975', 'https://openalex.org/W2315720511', 'https://openalex.org/W2320357607', 'https://openalex.org/W2418256209', 'https://openalex.org/W2602552022', 'https://openalex.org/W4232722838', 'https://openalex.org/W4255080146'], 'related_works': ['https://openalex.org/W4313043664', 'https://openalex.org/W4308336316', 'https://openalex.org/W3115145551', 'https://openalex.org/W2972954138', 'https://openalex.org/W2339295258', 'https://openalex.org/W2109552346', 'https://openalex.org/W2102695235', 'https://openalex.org/W2091545134', 'https://openalex.org/W2011083078', 'https://openalex.org/W2000813775'], 'abstract_inverted_index': {'SHP-2': [0, 52, 66, 73], '(': [1], 'PTPN11': [2, 89], '),': [3], 'a': [4], 'ubiquitously': [5], 'expressed': [6], 'protein': [7], 'tyrosine': [8], 'phosphatase,': [9], 'is': [10], 'critical': [11], 'for': [12, 101], 'hematopoietic': [13], 'cell': [14], 'development': [15], 'and': [16, 30, 43, 76], 'function': [17], 'owing': [18], 'to': [19, 98], 'its': [20, 79], 'essential': [21], 'role': [22], 'in': [23, 33, 94], 'growth': [24], 'factor/cytokine': [25], 'signaling.': [26], 'More': [27], 'importantly,': [28], 'germline': [29], 'somatic': [31], 'mutations': [32, 53], 'this': [34], 'phosphatase': [35], 'are': [36, 57], 'associated': [37], 'with': [38], 'Noonan': [39], 'syndrome,': [40, 42], 'Leopard': [41], 'childhood': [44], 'hematologic': [45, 91], 'malignancies.': [46], 'The': [47], 'molecular': [48], 'mechanisms': [49], 'by': [50], 'which': [51], 'induce': [54], 'these': [55, 102], 'diseases': [56], 'not': [58], 'fully': [59], 'understood,': [60], 'as': [61], 'the': [62, 86], 'biochemical': [63], 'bases': [64], 'of': [65, 78, 88], 'functions': [67], 'still': [68], 'remain': [69], 'elusive.': [70], 'Further': [71], 'understanding': [72], 'signaling': [74], 'activities': [75], 'identification': [77], 'interacting': [80], 'proteins/substrates': [81], 'will': [82], 'shed': [83], 'light': [84], 'on': [85], 'pathogenesis': [87], '-associated': [90], 'malignancies,': [92], 'which,': [93], 'turn,': [95], 'may': [96], 'lead': [97], 'novel': [99], 'therapeutics': [100], 'diseases.': [103]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2035008865', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2025-01-08T20:47:28.507556', 'created_date': '2016-06-24'}