Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2034914545', 'doi': 'https://doi.org/10.1358/mf.2000.22.2.796070', 'title': 'Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats', 'display_name': 'Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats', 'publication_year': 2000, 'publication_date': '2000-01-01', 'ids': {'openalex': 'https://openalex.org/W2034914545', 'doi': 'https://doi.org/10.1358/mf.2000.22.2.796070', 'mag': '2034914545', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10849891'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1358/mf.2000.22.2.796070', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S17778739', 'display_name': 'Methods and Findings in Experimental and Clinical Pharmacology', 'issn_l': '0379-0355', 'issn': ['0379-0355', '2013-0155'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313017', 'host_organization_name': 'Thomson Reuters', 'host_organization_lineage': ['https://openalex.org/P4310313017'], 'host_organization_lineage_names': ['Thomson Reuters'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111573763', 'display_name': 'H. Ogura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I55881946', 'display_name': 'Eisai (Japan)', 'ror': 'https://ror.org/04vvh7p27', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I55881946']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'None Ogura, H.', 'raw_affiliation_strings': ['Tsukuba Research Laboratories, Eisai Co., Ltd, Ibaraki, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Tsukuba Research Laboratories, Eisai Co., Ltd, Ibaraki, Japan;', 'institution_ids': ['https://openalex.org/I55881946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051525612', 'display_name': 'Takashi Kosasa', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'None Kosasa, T.', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041094009', 'display_name': 'Yuka Kuriya', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'None Kuriya, Y.', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111711613', 'display_name': 'Yukinori Yamanishi', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'None Yamanishi, Y.', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.727, 'has_fulltext': False, 'cited_by_count': 81, 'citation_normalized_percentile': {'value': 0.922026, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '22', 'issue': '2', 'first_page': '89', 'last_page': '89'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase and Neurodegenerative Diseases', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase and Neurodegenerative Diseases', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9764, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9672, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tacrine', 'display_name': 'Tacrine', 'score': 0.9658195}, {'id': 'https://openalex.org/keywords/cholinesterase', 'display_name': 'Cholinesterase', 'score': 0.7862801}, {'id': 'https://openalex.org/keywords/acetylcholinesterase-inhibitor', 'display_name': 'Acetylcholinesterase inhibitor', 'score': 0.7178347}, {'id': 'https://openalex.org/keywords/nucleus-basalis', 'display_name': 'Nucleus basalis', 'score': 0.5320901}], 'concepts': [{'id': 'https://openalex.org/C2780904820', 'wikidata': 'https://www.wikidata.org/wiki/Q415081', 'display_name': 'Donepezil', 'level': 4, 'score': 0.98351556}, {'id': 'https://openalex.org/C2779046751', 'wikidata': 'https://www.wikidata.org/wiki/Q421076', 'display_name': 'Tacrine', 'level': 4, 'score': 0.9658195}, {'id': 'https://openalex.org/C2778816929', 'wikidata': 'https://www.wikidata.org/wiki/Q22676679', 'display_name': 'Acetylcholinesterase', 'level': 3, 'score': 0.8624457}, {'id': 'https://openalex.org/C31896038', 'wikidata': 'https://www.wikidata.org/wiki/Q415635', 'display_name': 'Cholinesterase', 'level': 2, 'score': 0.7862801}, {'id': 'https://openalex.org/C2777544248', 'wikidata': 'https://www.wikidata.org/wiki/Q2592323', 'display_name': 'Acetylcholinesterase inhibitor', 'level': 4, 'score': 0.7178347}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.61293316}, {'id': 'https://openalex.org/C22885893', 'wikidata': 'https://www.wikidata.org/wiki/Q4862743', 'display_name': 'Cholinergic', 'level': 2, 'score': 0.60620683}, {'id': 'https://openalex.org/C44752575', 'wikidata': 'https://www.wikidata.org/wiki/Q1417562', 'display_name': 'Morris water navigation task', 'level': 3, 'score': 0.5618366}, {'id': 'https://openalex.org/C2778205193', 'wikidata': 'https://www.wikidata.org/wiki/Q1813830', 'display_name': 'Nucleus basalis', 'level': 4, 'score': 0.5320901}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.48314565}, {'id': 'https://openalex.org/C2779059548', 'wikidata': 'https://www.wikidata.org/wiki/Q383701', 'display_name': 'Aché', 'level': 4, 'score': 0.41755372}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.4149535}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.35540426}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.32815695}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.31355935}, {'id': 'https://openalex.org/C2779483572', 'wikidata': 'https://www.wikidata.org/wiki/Q83030', 'display_name': 'Dementia', 'level': 3, 'score': 0.2537281}, {'id': 'https://openalex.org/C104966671', 'wikidata': 'https://www.wikidata.org/wiki/Q12167532', 'display_name': 'Cholinergic neuron', 'level': 3, 'score': 0.23646992}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.23148713}, {'id': 'https://openalex.org/C169900460', 'wikidata': 'https://www.wikidata.org/wiki/Q2200417', 'display_name': 'Cognition', 'level': 2, 'score': 0.10454604}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0841676}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.06311792}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.060279876}], 'mesh': [{'descriptor_ui': 'D020532', 'descriptor_name': 'Basal Nucleus of Meynert', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D002800', 'descriptor_name': 'Cholinesterase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007189', 'descriptor_name': 'Indans', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007859', 'descriptor_name': 'Learning Disabilities', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001362', 'descriptor_name': 'Avoidance Learning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001362', 'descriptor_name': 'Avoidance Learning', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020532', 'descriptor_name': 'Basal Nucleus of Meynert', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D020532', 'descriptor_name': 'Basal Nucleus of Meynert', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002800', 'descriptor_name': 'Cholinesterase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077265', 'descriptor_name': 'Donepezil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007189', 'descriptor_name': 'Indans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007859', 'descriptor_name': 'Learning Disabilities', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018782', 'descriptor_name': 'Maze Learning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018782', 'descriptor_name': 'Maze Learning', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012601', 'descriptor_name': 'Scopolamine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012601', 'descriptor_name': 'Scopolamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013619', 'descriptor_name': 'Tacrine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013619', 'descriptor_name': 'Tacrine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1358/mf.2000.22.2.796070', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S17778739', 'display_name': 'Methods and Findings in Experimental and Clinical Pharmacology', 'issn_l': '0379-0355', 'issn': ['0379-0355', '2013-0155'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313017', 'host_organization_name': 'Thomson Reuters', 'host_organization_lineage': ['https://openalex.org/P4310313017'], 'host_organization_lineage_names': ['Thomson Reuters'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10849891', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4300703342', 'https://openalex.org/W2791827353', 'https://openalex.org/W242793321', 'https://openalex.org/W2383390938', 'https://openalex.org/W2170076671', 'https://openalex.org/W2138695511', 'https://openalex.org/W2081638043', 'https://openalex.org/W2051723148', 'https://openalex.org/W2034914545', 'https://openalex.org/W1977804769'], 'abstract_inverted_index': {'Donepezil': [0, 65, 106], 'is': [1], 'a': [2, 5, 49, 60], 'member': [3], 'of': [4, 8, 22, 51, 81, 99, 151], 'new': [6], 'class': [7], 'centrally': [9], 'acting': [10], 'cholinesterase': [11], 'inhibitors': [12], 'which': [13], 'preferentially': [14], 'inhibit': [15], 'acetylcholinesterase': [16], 'rather': [17], 'than': [18], 'butyrylcholinesterase.': [19], 'The': [20], 'effects': [21, 89], 'donepezil': [23, 41, 129, 152], 'on': [24, 90], 'learning': [25, 133], 'impairments': [26, 72, 91, 134], 'were': [27], 'investigated': [28], 'in': [29, 33, 44, 73, 92, 101, 111, 143, 153], 'some': [30], 'hypocholinergic': [31], 'models': [32], 'rats.': [34, 144], 'In': [35], 'nucleus': [36], 'basalis': [37], 'magnocellularis': [38], '(NBM)-lesioned': [39], 'rats,': [40], 'alleviated': [42], 'deficits': [43], 'passive': [45], 'avoidance': [46], 'response': [47], 'at': [48, 66, 115, 122], 'dose': [50], '0.125': [52], 'mg/kg': [53, 68], 'and': [54], 'higher,': [55], 'while': [56], 'tacrine': [57, 85, 119], 'had': [58, 86], 'only': [59], 'tendency': [61], 'toward': [62], 'improved': [63], 'performance.': [64], '0.5': [67, 116], 'effectively': [69], 'counteracted': [70], 'acquisition': [71], 'the': [74, 82, 102, 112, 148], 'water': [75], 'maze': [76, 114], 'task': [77], 'induced': [78, 135], 'by': [79, 136], 'lesions': [80], 'medial': [83], 'septum;': [84], 'no': [87], 'significant': [88], 'this': [93], 'task.': [94], 'Scopolamine': [95], 'caused': [96], 'an': [97], 'increase': [98], 'errors': [100, 110, 121], '8-arm': [103], 'radial': [104, 113], 'maze.': [105], 'significantly': [107], 'decreased': [108, 120], 'scopolamine-induced': [109], 'mg/kg,': [117], 'whereas': [118], '2': [123], 'mg/kg.': [124], 'These': [125, 145], 'results': [126], 'suggest': [127], 'that': [128, 138], 'can': [130], 'clearly': [131], 'minimize': [132], 'treatments': [137], 'cause': [139], 'central': [140], 'cholinergic': [141], 'deficiencies': [142], 'findings': [146], 'support': [147], 'clinical': [149], 'efficacy': [150], "Alzheimer's": [154], 'disease.': [155]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2034914545', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-14T01:27:36.115514', 'created_date': '2016-06-24'}