Publication Information

{'id': 'https://openalex.org/W2034838167', 'doi': 'https://doi.org/10.7326/0003-4819-132-5-200003070-00017', 'title': 'Hydroxyurea-Induced Leg Ulcers Treated with Apligraf', 'display_name': 'Hydroxyurea-Induced Leg Ulcers Treated with Apligraf', 'publication_year': 2000, 'publication_date': '2000-03-07', 'ids': {'openalex': 'https://openalex.org/W2034838167', 'doi': 'https://doi.org/10.7326/0003-4819-132-5-200003070-00017', 'mag': '2034838167', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10691597'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-132-5-200003070-00017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100627688', 'display_name': 'Francisco Flores', 'orcid': 'https://orcid.org/0000-0002-8974-9717'}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Francisco Flores', 'raw_affiliation_strings': ['Miami, FL 33136 (Eaglstein)', 'Miami, FL 33136 (Flores)', 'University of Miami', 'University of Miami; Miami, FL 33136 (Flores)University of Miami; Miami, FL 33136 (Eaglstein)University of Miami; Miami, FL 33136 (Kirsner)'], 'affiliations': [{'raw_affiliation_string': 'University of Miami; Miami, FL 33136 (Flores)University of Miami; Miami, FL 33136 (Eaglstein)University of Miami; Miami, FL 33136 (Kirsner)', 'institution_ids': ['https://openalex.org/I145608581']}, {'raw_affiliation_string': 'Miami, FL 33136 (Eaglstein)', 'institution_ids': []}, {'raw_affiliation_string': 'University of Miami', 'institution_ids': ['https://openalex.org/I145608581']}, {'raw_affiliation_string': 'Miami, FL 33136 (Flores)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110064601', 'display_name': 'William A. Eaglstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William A. Eaglstein', 'raw_affiliation_strings': ['Miami, FL 33136 (Eaglstein)', 'Miami, FL 33136 (Flores)', 'University of Miami', 'University of Miami; Miami, FL 33136 (Flores)University of Miami; Miami, FL 33136 (Eaglstein)University of Miami; Miami, FL 33136 (Kirsner)'], 'affiliations': [{'raw_affiliation_string': 'Miami, FL 33136 (Eaglstein)', 'institution_ids': []}, {'raw_affiliation_string': 'University of Miami', 'institution_ids': ['https://openalex.org/I145608581']}, {'raw_affiliation_string': 'Miami, FL 33136 (Flores)', 'institution_ids': []}, {'raw_affiliation_string': 'University of Miami; Miami, FL 33136 (Flores)University of Miami; Miami, FL 33136 (Eaglstein)University of Miami; Miami, FL 33136 (Kirsner)', 'institution_ids': ['https://openalex.org/I145608581']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045611437', 'display_name': 'Robert S. Kirsner', 'orcid': 'https://orcid.org/0000-0002-6824-9844'}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert S. Kirsner', 'raw_affiliation_strings': ['Miami, FL 33136 (Eaglstein)', 'Miami, FL 33136 (Flores)', 'University of Miami', 'University of Miami; Miami, FL 33136 (Flores)University of Miami; Miami, FL 33136 (Eaglstein)University of Miami; Miami, FL 33136 (Kirsner)'], 'affiliations': [{'raw_affiliation_string': 'Miami, FL 33136 (Eaglstein)', 'institution_ids': []}, {'raw_affiliation_string': 'University of Miami', 'institution_ids': ['https://openalex.org/I145608581']}, {'raw_affiliation_string': 'Miami, FL 33136 (Flores)', 'institution_ids': []}, {'raw_affiliation_string': 'University of Miami; Miami, FL 33136 (Flores)University of Miami; Miami, FL 33136 (Eaglstein)University of Miami; Miami, FL 33136 (Kirsner)', 'institution_ids': ['https://openalex.org/I145608581']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.907407, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '132', 'issue': '5', 'first_page': '417', 'last_page': '417'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11628', 'display_name': 'Myeloproliferative Neoplasms: Diagnosis and Treatment', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11628', 'display_name': 'Myeloproliferative Neoplasms: Diagnosis and Treatment', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10554', 'display_name': 'Hemoglobinopathies and Related Disorders', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/miami', 'display_name': 'Miami', 'score': 0.9728403}], 'concepts': [{'id': 'https://openalex.org/C2606647', 'wikidata': 'https://www.wikidata.org/wiki/Q6827257', 'display_name': 'Miami', 'level': 2, 'score': 0.9728403}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7188213}, {'id': 'https://openalex.org/C159390177', 'wikidata': 'https://www.wikidata.org/wiki/Q9161265', 'display_name': 'Soil science', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C39432304', 'wikidata': 'https://www.wikidata.org/wiki/Q188847', 'display_name': 'Environmental science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D006918', 'descriptor_name': 'Hydroxyurea', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D007871', 'descriptor_name': 'Leg Ulcer', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D007871', 'descriptor_name': 'Leg Ulcer', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D017768', 'descriptor_name': 'Skin, Artificial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006918', 'descriptor_name': 'Hydroxyurea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007871', 'descriptor_name': 'Leg Ulcer', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015464', 'descriptor_name': 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015464', 'descriptor_name': 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-132-5-200003070-00017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10691597', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.49}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 3, 'referenced_works': ['https://openalex.org/W1983702524', 'https://openalex.org/W2055030955', 'https://openalex.org/W2081947192'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W4238016385', 'https://openalex.org/W3118362297', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2586801360', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455'], 'abstract_inverted_index': {'Letters7': [0], 'March': [1, 526, 547], '2000Hydroxyurea-Induced': [2], 'Leg': [3, 226, 320, 387], 'Ulcers': [4, 321], 'Treated': [5], 'with': [6, 115, 125, 229, 355, 370, 392, 443, 450], 'ApligrafFrancisco': [7], 'Flores,': [8, 19, 266], 'MD,': [9, 13], 'William': [10, 39, 268], 'A.': [11, 40, 269], 'Eaglstein,': [12, 41, 270], 'and': [14, 61, 85, 146, 174, 246, 262, 302, 307, 330, 401, 418, 432, 460, 483, 535], 'Robert': [15, 62, 272], 'S.': [16, 63, 273], 'Kirsner,': [17, 64, 274], 'MDFrancisco': [18], 'MDUniversity': [20, 42, 65], 'of': [21, 27, 33, 43, 49, 55, 66, 72, 78, 118, 166, 171, 182, 249, 277, 283, 289, 319, 346, 380, 383, 396, 404, 414, 454, 467, 477, 490, 501, 509, 517, 557], 'Miami;': [22, 28, 34, 44, 50, 56, 67, 73, 79, 278, 284, 290], 'Miami,': [23, 29, 35, 45, 51, 57, 68, 74, 80, 279, 285, 291], 'FL': [24, 30, 36, 46, 52, 58, 69, 75, 81, 280, 286, 292], '33136': [25, 31, 37, 47, 53, 59, 70, 76, 82, 281, 287, 293], '(Flores)University': [26, 48, 71, 282], '(Eaglstein)University': [32, 54, 77, 288], '(Kirsner),': [38, 60], '(Kirsner)Author,': [83], 'Article,': [84, 261], 'Disclosure': [86, 263], 'Informationhttps://doi.org/10.7326/0003-4819-132-5-200003070-00017': [87], 'SectionsAboutFull': [88], 'TextPDF': [89], 'ToolsAdd': [90], 'to': [91, 105, 189, 366], 'favoritesDownload': [92], 'CitationsTrack': [93], 'CitationsPermissions': [94], 'ShareFacebookTwitterLinkedInRedditEmail': [95], 'TO': [96], 'THE': [97], 'EDITOR:Hydroxyurea': [98], 'is': [99, 185, 341], 'an': [100, 305], 'antineoplastic': [101], 'agent': [102], 'commonly': [103], 'used': [104], 'treat': [106], 'myeloproliferative': [107], 'disorders.': [108], 'We': [109], 'report': [110], 'on': [111, 135, 422, 426], 'a': [112, 116, 132, 186, 251, 390, 405, 440], '74-year-old': [113], 'woman': [114], 'history': [117], 'chronic': [119, 368], 'myelocytic': [120, 532], 'leukemia': [121], 'who': [122], 'was': [123, 141], 'treated': [124], 'hydroxyurea.': [126], 'During': [127], 'therapy,': [128], 'the': [129, 149, 247, 342, 381, 412, 465, 488], 'patient': [130, 441], 'developed': [131], 'cutaneous': [133], 'ulcer': [134, 150, 184, 191, 332, 438], 'her': [136], 'right': [137], 'lateral': [138], 'malleolus': [139], 'that': [140], 'accompanied': [142], 'by': [143, 334, 554], 'severe': [144], 'pain': [145], 'burning': [147], 'at': [148], 'site.': [151], 'Malleoli': [152], 'ulcers': [153, 168, 227, 353, 417], 'have': [154], 'been': [155], 'uncommonly': [156], 'reported': [157], 'in': [158, 207, 310, 322, 336, 350, 389, 398, 411, 439, 448, 464, 487], 'patients': [159], 'receiving': [160], 'hydroxyurea': [161, 231, 356, 444], '(1,': [162], '2).': [163], 'Postulated': [164], 'mechanisms': [165], 'hydroxyurea-induced': [167, 183], 'include': [169], 'inhibition': [170], 'DNA': [172], 'synthesis': [173], 'subsequent': [175], 'keratinocyte': [176], 'cell': [177, 338, 372, 408], 'death.': [178], 'A': [179, 316], 'typical': [180], 'feature': [181], 'poor': [187], 'response': [188], 'standard': [190], 'therapeutic': [192, 343], 'agents,': [193], 'such': [194], '...References1.': [195], 'Best': [196, 327], 'PJ,': [197], 'Daoud': [198], 'MS,': [199], 'Pittelkow': [200], 'MR,': [201], 'Petitt': [202], 'RM.': [203], 'Hydroxyurea-induced': [204], 'leg': [205, 416], 'ulceration': [206], '14': [208], 'patients.': [209], 'Ann': [210], 'Intern': [211], 'Med.': [212], '1998;128:29-32.': [213], 'LinkGoogle': [214], 'Scholar2.': [215], 'Weinlich': [216], 'G,': [217, 219], 'Schuler': [218], 'Greil': [220], 'R,': [221], 'Kofler': [222], 'H,': [223], 'Fritsch': [224], 'P.': [225], 'associated': [228, 354, 442], 'long-term': [230], 'therapy.': [232], 'J': [233], 'Am': [234], 'Acad': [235], 'Dermatol.': [236], '1998;39:372-4.': [237], 'CrossrefMedlineGoogle': [238, 258], 'Scholar3.': [239], 'Eaglstein': [240], 'WH,': [241], 'Falanga': [242], 'V.': [243], 'Tissue': [244, 430], 'engineering': [245, 400], 'development': [248], 'Apligraf,': [250], 'human': [252], 'skin': [253], 'equivalent.': [254], 'Clin': [255], 'Therapeutics.': [256], '1997;19:894-905.': [257], 'Scholar': [259], 'Author,': [260], 'InformationAuthors:': [264], 'Francisco': [265], 'MD;': [267, 271], 'MDAffiliations:': [275], 'University': [276], '(Kirsner)': [294], 'PreviousarticleNextarticle': [295], 'Advertisement': [296], 'FiguresReferencesRelatedDetails': [297], 'Metrics': [298], 'Cited': [299], 'byAtorvastan,': [300], 'Apsirin': [301], 'Hydorxyurea': [303], 'for': [304], 'Effective': [306], 'Low-Cost': [308], 'Treatment': [309, 466, 489], 'High-Risk': [311], 'Polycythemia': [312], 'VeraCommon,': [313], 'But': [314], 'Neglected:': [315], 'Comprehensive': [317], 'Review': [318], 'Sickle': [323], 'Cell': [324, 348], 'DiseaseAtypical': [325], 'wounds.': [326], 'clinical': [328], 'practice': [329], 'challengesLeg': [331], 'induced': [333], 'hydroxycarbamide': [335], 'sickle': [337], 'disease:': [339], 'What': [340], 'impact?The': [344], 'Role': [345], 'Stem': [347], 'Therapeutics': [349], 'Wound': [351], 'HealingCutaneous': [352], 'therapyAtypical': [357], 'ulcersEmerging': [358], 'Adverse': [359], 'Cutaneous': [360], 'Drug': [361, 536], 'ReactionsA': [362], 'multidisciplinary': [363], 'team': [364], 'approach': [365], 'hydroxyurea-associated': [367], 'wound': [369], 'squamous': [371], 'carcinomaUlzerationen': [373], 'unter': [374], 'Therapie': [375], 'mit': [376], 'HydroxyharnstoffA': [377], 'Case': [378], 'Report': [379], 'Eradication': [382], 'Pseudomonas': [384], 'aeruginosa': [385], 'from': [386], 'Ulcer': [388], 'Patient': [391], 'Essential': [393], 'ThrombocythemiaThe': [394], 'role': [395], 'fibroblasts': [397], 'tissue': [399], 'regenerationA': [402], 'review': [403], 'bi-layered': [406], 'living': [407], 'treatment': [409, 413], '(Apligraf�)': [410], 'venous': [415], 'diabetic': [419], 'foot': [420], 'ulcersUpdate': [421], 'Tissue-Engineered': [423, 427, 455, 478, 506, 514, 522], 'Biological': [424, 428], 'DressingsUpdate': [425], 'DressingsCutaneous': [429], 'Engineering': [431], 'Lower': [433], 'Extremity': [434], 'Wounds': [435, 470, 493], '(Part': [436], '2)Leg': [437], 'therapyHydroxyurea-Induced': [445], 'Skin': [446, 456, 458, 479, 481], 'Ulcerations': [447], 'Patients': [449], 'Chronic': [451], 'Myeloproliferative': [452], 'DisordersEvaluation': [453], '(Human': [457, 480], 'Substitute)': [459, 482], 'Secondary': [461, 484], 'Intention': [462, 485], 'Healing': [463, 486], 'Full': [468, 491], 'Thickness': [469, 492], 'after': [471, 494], 'Mohs': [472, 495], 'Micrographic': [473, 496], 'or': [474, 497], 'Excisional': [475, 498], 'SurgeryEvaluation': [476], 'SurgeryEffective': [499], 'Management': [500, 508, 516], 'Difficult': [502, 510, 518], 'Surgical': [503, 511, 519], 'Defects': [504, 512, 520], 'Using': [505, 513, 521], 'SkinEffective': [507, 515], 'SkinCurrent': [523], 'AwarenessHydroxycarbamide': [524], '7': [525, 546], '2000Volume': [527], '132,': [528], 'Issue': [529, 544], '5Page:': [530], '417-418KeywordsAntibioticsChemotherapyChronic': [531], 'leukemiaDNA': [533], 'synthesisFood': [534], 'AdministrationKeratinocytesMyeloproliferative': [537], 'disordersPainPatient': [538], 'advocacyUlcers': [539], 'ePublished:': [540], '15': [541], 'August': [542], '2000': [543, 548, 553], 'Published:': [545], 'Copyright': [549], '&': [550], 'PermissionsCopyright': [551], '©': [552], 'American': [555], 'College': [556], 'Physicians.': [558], 'All': [559], 'Rights': [560], 'Reserved.PDF': [561], 'downloadLoading': [562], '...': [563]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2034838167', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-10T03:33:05.736237', 'created_date': '2016-06-24'}