Publication Information

{'id': 'https://openalex.org/W2034787150', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-2740', 'title': 'Abstract 2740: The role of JNK in the development of pancreatic cancer.', 'display_name': 'Abstract 2740: The role of JNK in the development of pancreatic cancer.', 'publication_year': 2013, 'publication_date': '2013-04-01', 'ids': {'openalex': 'https://openalex.org/W2034787150', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-2740', 'mag': '2034787150'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-2740', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100724725', 'display_name': 'Ryota Takahashi', 'orcid': 'https://orcid.org/0000-0001-7886-8481'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryota Takahashi', 'raw_affiliation_strings': ['1The University of Tokyo, Tokyo, Japan.'], 'affiliations': [{'raw_affiliation_string': '1The University of Tokyo, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060570462', 'display_name': 'Yoshihiro Hirata', 'orcid': 'https://orcid.org/0000-0002-8324-366X'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshihiro Hirata', 'raw_affiliation_strings': ['1The University of Tokyo, Tokyo, Japan.'], 'affiliations': [{'raw_affiliation_string': '1The University of Tokyo, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086554763', 'display_name': 'Kosuke Sakitani', 'orcid': 'https://orcid.org/0000-0002-4537-6023'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kosuke Sakitani', 'raw_affiliation_strings': ['1The University of Tokyo, Tokyo, Japan.'], 'affiliations': [{'raw_affiliation_string': '1The University of Tokyo, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039278083', 'display_name': 'Wachiko Nakata', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Wachiko Nakata', 'raw_affiliation_strings': ['1The University of Tokyo, Tokyo, Japan.'], 'affiliations': [{'raw_affiliation_string': '1The University of Tokyo, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011031407', 'display_name': 'Hiroto Kinoshita', 'orcid': 'https://orcid.org/0000-0002-8179-6017'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroto Kinoshita', 'raw_affiliation_strings': ['1The University of Tokyo, Tokyo, Japan.'], 'affiliations': [{'raw_affiliation_string': '1The University of Tokyo, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072881222', 'display_name': 'Yoku Hayakawa', 'orcid': 'https://orcid.org/0000-0002-3988-2499'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoku Hayakawa', 'raw_affiliation_strings': ['1The University of Tokyo, Tokyo, Japan.'], 'affiliations': [{'raw_affiliation_string': '1The University of Tokyo, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073692464', 'display_name': 'Hayato Nakagawa', 'orcid': 'https://orcid.org/0000-0002-6973-5094'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hayato Nakagawa', 'raw_affiliation_strings': ['1The University of Tokyo, Tokyo, Japan.'], 'affiliations': [{'raw_affiliation_string': '1The University of Tokyo, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026907725', 'display_name': 'Hideaki Ijichi', 'orcid': 'https://orcid.org/0000-0002-2379-7986'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideaki Ijichi', 'raw_affiliation_strings': ['1The University of Tokyo, Tokyo, Japan.'], 'affiliations': [{'raw_affiliation_string': '1The University of Tokyo, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017568301', 'display_name': 'Shin Maeda', 'orcid': 'https://orcid.org/0000-0002-0246-1594'}, 'institutions': [{'id': 'https://openalex.org/I89630735', 'display_name': 'Yokohama City University', 'ror': 'https://ror.org/0135d1r83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I89630735']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shin Maeda', 'raw_affiliation_strings': ['2Yokohama City University, Yokohama, Japan.'], 'affiliations': [{'raw_affiliation_string': '2Yokohama City University, Yokohama, Japan.', 'institution_ids': ['https://openalex.org/I89630735']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046522736', 'display_name': 'Kazuhiko Koike', 'orcid': 'https://orcid.org/0000-0002-9787-1907'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuhiko Koike', 'raw_affiliation_strings': ['1The University of Tokyo, Tokyo, Japan.'], 'affiliations': [{'raw_affiliation_string': '1The University of Tokyo, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.474709, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 65, 'max': 72}, 'biblio': {'volume': '73', 'issue': '8_Supplement', 'first_page': '2740', 'last_page': '2740'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.9748, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.9748, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic and Hepatic Oncology Research', 'score': 0.9081, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780210213', 'wikidata': 'https://www.wikidata.org/wiki/Q212961', 'display_name': 'Pancreatic cancer', 'level': 3, 'score': 0.7780771}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.6401905}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6389237}, {'id': 'https://openalex.org/C199835354', 'wikidata': 'https://www.wikidata.org/wiki/Q15311861', 'display_name': 'Cyclin D1', 'level': 4, 'score': 0.5551863}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.47240585}, {'id': 'https://openalex.org/C2778764654', 'wikidata': 'https://www.wikidata.org/wiki/Q9618', 'display_name': 'Pancreas', 'level': 2, 'score': 0.44297627}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.42710057}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.39974713}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36368728}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.27426106}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25865597}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.22995779}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.1753026}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-2740', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.78, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2948897165', 'https://openalex.org/W2426219085', 'https://openalex.org/W2415462806', 'https://openalex.org/W2162154120', 'https://openalex.org/W2086659676', 'https://openalex.org/W2081095462', 'https://openalex.org/W2039143308', 'https://openalex.org/W2012081960', 'https://openalex.org/W1986004753', 'https://openalex.org/W1982584242'], 'abstract_inverted_index': {'Abstract': [0], 'C-Jun': [1], 'NH2-terminal': [2], 'kinase': [3, 11], '(JNK)': [4], 'is': [5, 16, 38, 54, 356], 'a': [6, 20, 199, 377], 'member': [7], 'of': [8, 22, 43, 49, 65, 70, 78, 97, 113, 120, 138, 149, 166, 202, 215, 220, 226, 242, 251, 271, 282, 291, 298, 323, 341, 361, 367, 407, 412, 418, 423], 'mitogen-activated': [9], 'protein': [10], '(MAPK)': [12], 'family,': [13], 'and': [14, 29, 73, 132, 145, 159, 182, 188, 205, 245, 257, 311, 370], 'it': [15, 32], 'known': [17], 'to': [18, 173, 239, 265], 'regulate': [19], 'variety': [21], 'cellular': [23], 'activities': [24], 'including': [25], 'apoptosis,': [26], 'survival,': [27], 'differentiation,': [28], 'proliferation.': [30], 'Recently,': [31], 'has': [33], 'been': [34], 'suggested': [35], 'that': [36, 350], 'JNK': [37, 50, 66, 79, 87, 107, 130, 157, 177, 216, 233, 309, 342, 354, 355, 374, 408], 'involved': [39, 357], 'in': [40, 51, 67, 91, 123, 140, 209, 259, 287, 319, 358, 409], 'the': [41, 47, 63, 68, 75, 260, 320, 339, 359, 365, 410, 419, 424], 'development': [42, 69, 360, 411], 'several': [44], 'cancers,': [45], 'but': [46], 'role': [48, 64, 406], 'pancreatic': [52, 71, 82, 93, 98, 124, 153, 203, 206, 243, 261, 288, 302, 324, 362, 381, 413], 'cancer': [53, 72, 94, 99, 125, 154, 207, 262, 289, 303, 325, 363], 'not': [55], 'fully': [56], 'elucidated.': [57], 'In': [58, 84], 'this': [59], 'study,': [60], 'we': [61], 'examined': [62], 'evaluated': [74], 'therapeutic': [76], 'effect': [77, 340], 'inhibition': [80, 343], 'on': [81, 344], 'cancer.': [83, 382, 414], 'immunohistochemical': [85, 246], 'staining,': [86], 'activation': [88, 178, 214], 'was': [89, 102, 127, 171, 196, 274, 285, 306, 315], 'observed': [90, 286], 'human': [92], 'specimens.': [95], 'Growth': [96], 'cell': [100, 133, 304, 368], 'lines': [101, 305], 'inhibited': [103, 316], 'by': [104, 111, 129, 143, 162, 179, 277, 295, 308, 313, 317, 328], 'treatment': [105], 'with': [106, 232, 332], 'inhibitor': [108, 234], 'SP600125': [109, 278, 329], 'or': [110, 117, 223, 330, 336], 'transfection': [112], 'siRNAs': [114, 333], 'against': [115, 334], 'JNK1': [116, 144, 335], 'JNK2.': [118], 'Expression': [119], 'cyclin': [121, 255], 'D1': [122, 169, 256], 'cells': [126, 139, 155, 326], 'decreased': [128, 164, 307], 'inhibition,': [131, 310], 'cycle': [134, 369], 'analysis': [135], 'showed': [136, 212, 248], 'accumulation': [137], 'G0/G1': [141], 'phase': [142], 'JNK2': [146], 'inhibition.': [147], 'Induction': [148], 'oncogenic': [150, 351], 'Ras': [151], 'into': [152], 'promoted': [156], 'activation,': [158], 'KRAS': [160], 'knockdown': [161], 'siRNA': [163], 'phosphorylation': [165], 'JNK.': [167], 'Cyclin': [168], 'expression': [170, 187, 250], 'shown': [172], 'be': [174, 376], 'regulated': [175], 'through': [176, 364], 'luciferase': [180], 'assay': [181], 'real-time': [183], 'RT-PCR.': [184], 'Pancreas-specific': [185], 'KrasG12D': [186, 221], 'type': [189], 'II': [190], 'TGFβreceptor': [191], 'knockout': [192], 'mice': [193, 211, 222, 231, 273, 293], '(KrasG12D+Tgfbr2KO': [194], 'mice)': [195], 'used': [197], 'as': [198], 'mouse': [200], 'model': [201], 'cancer,': [204, 244], 'developed': [208], 'KrasG12D+Tgfbr2KO': [210, 230, 272, 292], 'higher': [213], 'than': [217], 'PanIN': [218], 'tissue': [219, 290], 'normal': [224], 'pancreas': [225], 'wild-type': [227], 'mice.': [228], 'Treating': [229], 'for': [235, 380, 427], '4': [236], 'weeks': [237], 'led': [238], 'less': [240], 'progression': [241], 'staining': [247], 'reduced': [249], 'phosphorylated': [252], 'JNK,': [253], 'c-jun,': [254], 'PCNA': [258], 'tissues': [263], 'compared': [264], 'control': [266], 'vehicle.': [267], 'The': [268, 405], 'survival': [269], 'time': [270], 'significantly': [275], 'prolonged': [276], 'treatment.': [279], 'Decreased': [280], 'number': [281], 'blood': [283], 'vessels': [284], 'treated': [294, 327], 'SP600125.': [296], 'Secretion': [297], 'angiogenic': [299], 'cytokines': [300], 'from': [301], 'angiogenesis': [312], 'HUVEC': [314], 'incubating': [318], 'conditioned': [321], 'medium': [322], 'transfected': [331], 'JNK2,': [337], 'indicating': [338], 'tumor': [345, 371], 'angiogenesis.': [346, 372], 'These': [347], 'data': [348], 'indicate': [349], 'K-ras': [352], 'activates': [353], 'regulation': [366], 'Inhibiting': [373], 'may': [375], 'potential': [378], 'therapy': [379], 'Citation': [383], 'Format:': [384], 'Ryota': [385], 'Takahashi,': [386], 'Yoshihiro': [387], 'Hirata,': [388], 'Kosuke': [389], 'Sakitani,': [390], 'Wachiko': [391], 'Nakata,': [392], 'Hiroto': [393], 'Kinoshita,': [394], 'Yoku': [395], 'Hayakawa,': [396], 'Hayato': [397], 'Nakagawa,': [398], 'Hideaki': [399], 'Ijichi,': [400], 'Shin': [401], 'Maeda,': [402], 'Kazuhiko': [403], 'Koike.': [404], '[abstract].': [415], 'In:': [416], 'Proceedings': [417], '104th': [420], 'Annual': [421], 'Meeting': [422], 'American': [425], 'Association': [426], 'Cancer': [428, 438], 'Research;': [429], '2013': [430], 'Apr': [431], '6-10;': [432], 'Washington,': [433], 'DC.': [434], 'Philadelphia': [435], '(PA):': [436], 'AACR;': [437], 'Res': [439], '2013;73(8': [440], 'Suppl):Abstract': [441], 'nr': [442], '2740.': [443], 'doi:10.1158/1538-7445.AM2013-2740': [444]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2034787150', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-08T15:20:30.362441', 'created_date': '2016-06-24'}