Title: Enhanced Efficacy of Superparamagnetic Iron Oxide Nanoparticles Against Antibiotic‐Resistant Biofilms in the Presence of Metabolites
Abstract: Advanced MaterialsVolume 25, Issue 40 p. 5706-5713 Communication Enhanced Efficacy of Superparamagnetic Iron Oxide Nanoparticles Against Antibiotic-Resistant Biofilms in the Presence of Metabolites Naside G. Durmus, Naside G. Durmus Center for Biomedical Engineering, School of Engineering, Brown University, RI, USA, 02912Search for more papers by this authorErik N. Taylor, Erik N. Taylor Department of Chemical Engineering, Northeastern University, Boston, MA, USA, 02215Search for more papers by this authorKim M. Kummer, Kim M. Kummer Center for Biomedical Engineering, School of Engineering, Brown University, RI, USA, 02912Search for more papers by this authorThomas J. Webster, Corresponding Author Thomas J. Webster Department of Chemical Engineering, Northeastern University, Boston, MA, USA, 02215E-mail: [email protected]Search for more papers by this author Naside G. Durmus, Naside G. Durmus Center for Biomedical Engineering, School of Engineering, Brown University, RI, USA, 02912Search for more papers by this authorErik N. Taylor, Erik N. Taylor Department of Chemical Engineering, Northeastern University, Boston, MA, USA, 02215Search for more papers by this authorKim M. Kummer, Kim M. Kummer Center for Biomedical Engineering, School of Engineering, Brown University, RI, USA, 02912Search for more papers by this authorThomas J. Webster, Corresponding Author Thomas J. Webster Department of Chemical Engineering, Northeastern University, Boston, MA, USA, 02215E-mail: [email protected]Search for more papers by this author First published: 20 August 2013 https://doi.org/10.1002/adma.201302627Citations: 120Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Antibiotic resistance and the lack of new antibacterial agents cause major challenges for the treatment of infections. Here, we describe a simple, broad-spectrum, and low-cost dual-sided approach which uses superparamagnetic iron oxide particles (SPION) in combination with fructose metabolites as an alternative to existing antibacterial strategies. This strategy offers further improved efficacy of SPION against persistent gram-positive and gram-negative bacteria infections by manipulating the biofilm metabolic microenvironment and outperforms vancomycin (the antibiotic of last resort), creating a new nanotechnology-driven approach. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. 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Citing Literature Volume25, Issue40October 25, 2013Pages 5706-5713 ReferencesRelatedInformation
Publication Year: 2013
Publication Date: 2013-08-20
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 143
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