Physiologically Based Pharmacokinetic Modelling to Predict Single- and Multiple-Dose Human Pharmacokinetics of Bitopertin

Name: Work Video:
Duration: 3 min 30 s
Neil Parrott; Dominik Hainzl; Daniela Alberati; Carsten Hofmann; Richard A. Robson; Bruno Boutouyrie; Meret Martin‐Facklam
{'id': 'https://openalex.org/W2034505552', 'doi': 'https://doi.org/10.1007/s40262-013-0061-x', 'title': 'Physiologically Based Pharmacokinetic Modelling to Predict Single- and Multiple-Dose Human Pharmacokinetics of Bitopertin', 'display_name': 'Physiologically Based Pharmacokinetic Modelling to Predict Single- and Multiple-Dose Human Pharmacokinetics of Bitopertin', 'publication_year': 2013, 'publication_date': '2013-04-16', 'ids': {'openalex': 'https://openalex.org/W2034505552', 'doi': 'https://doi.org/10.1007/s40262-013-0061-x', 'mag': '2034505552', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23591780'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s40262-013-0061-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S69290020', 'display_name': 'Clinical Pharmacokinetics', 'issn_l': '0312-5963', 'issn': ['0312-5963', '1179-1926'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055401474', 'display_name': 'Neil Parrott', 'orcid': 'https://orcid.org/0000-0001-6821-7714'}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Neil Parrott', 'raw_affiliation_strings': ['Non-Clinical Safety, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Non-Clinical Safety, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland', 'institution_ids': ['https://openalex.org/I118019719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000148505', 'display_name': 'Dominik Hainzl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Dominik Hainzl', 'raw_affiliation_strings': ['Non-Clinical Safety, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Non-Clinical Safety, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland', 'institution_ids': ['https://openalex.org/I118019719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113595116', 'display_name': 'Daniela Alberati', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Daniela Alberati', 'raw_affiliation_strings': ['Discovery Neuroscience, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Discovery Neuroscience, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland', 'institution_ids': ['https://openalex.org/I118019719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060199728', 'display_name': 'Carsten Hofmann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Carsten Hofmann', 'raw_affiliation_strings': ['Clinical Pharmacology, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Clinical Pharmacology, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland', 'institution_ids': ['https://openalex.org/I118019719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108417421', 'display_name': 'Richard A. Robson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126461', 'display_name': 'Christchurch Clinical Studies Trust', 'ror': 'https://ror.org/02wccra50', 'country_code': 'NZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210126461']}], 'countries': ['NZ'], 'is_corresponding': False, 'raw_author_name': 'Richard Robson', 'raw_affiliation_strings': ['Christchurch Clinical Studies Trust, Christchurch, New Zealand'], 'affiliations': [{'raw_affiliation_string': 'Christchurch Clinical Studies Trust, Christchurch, New Zealand', 'institution_ids': ['https://openalex.org/I4210126461']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051320846', 'display_name': 'Bruno Boutouyrie', 'orcid': None}, 'institutions': [], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Bruno Boutouyrie', 'raw_affiliation_strings': ['Clinical Pharmacology, Eysins, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Clinical Pharmacology, Eysins, Switzerland', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013394867', 'display_name': 'Meret Martin‐Facklam', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Meret Martin-Facklam', 'raw_affiliation_strings': ['Clinical Pharmacology, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Clinical Pharmacology, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland', 'institution_ids': ['https://openalex.org/I118019719']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.112, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.922754, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '52', 'issue': '8', 'first_page': '673', 'last_page': '683'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10256', 'display_name': 'Drug Solubulity and Delivery Systems', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C185867374', 'wikidata': 'https://www.wikidata.org/wiki/Q2562769', 'display_name': 'Physiologically based pharmacokinetic modelling', 'level': 3, 'score': 0.9635151}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.94359756}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.65147805}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5020752}, {'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.49328703}, {'id': 'https://openalex.org/C125287762', 'wikidata': 'https://www.wikidata.org/wiki/Q1758948', 'display_name': 'Absorption (acoustics)', 'level': 2, 'score': 0.4257006}, {'id': 'https://openalex.org/C181389837', 'wikidata': 'https://www.wikidata.org/wiki/Q461809', 'display_name': 'Bioavailability', 'level': 2, 'score': 0.42040277}, {'id': 'https://openalex.org/C76318530', 'wikidata': 'https://www.wikidata.org/wiki/Q16833590', 'display_name': 'Area under the curve', 'level': 2, 'score': 0.41940737}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.28778365}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.14484486}, {'id': 'https://openalex.org/C159985019', 'wikidata': 'https://www.wikidata.org/wiki/Q181790', 'display_name': 'Composite material', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D014150', 'descriptor_name': 'Antipsychotic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D014150', 'descriptor_name': 'Antipsychotic Agents', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D013450', 'descriptor_name': 'Sulfones', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D013450', 'descriptor_name': 'Sulfones', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014150', 'descriptor_name': 'Antipsychotic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050487', 'descriptor_name': 'Glycine Plasma Membrane Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050487', 'descriptor_name': 'Glycine Plasma Membrane Transport Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008252', 'descriptor_name': 'Macaca fascicularis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013450', 'descriptor_name': 'Sulfones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s40262-013-0061-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S69290020', 'display_name': 'Clinical Pharmacokinetics', 'issn_l': '0312-5963', 'issn': ['0312-5963', '1179-1926'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23591780', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.62}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1499768710', 'https://openalex.org/W1507804974', 'https://openalex.org/W1522767714', 'https://openalex.org/W152943885', 'https://openalex.org/W1600201035', 'https://openalex.org/W164384631', 'https://openalex.org/W1964411950', 'https://openalex.org/W1968101595', 'https://openalex.org/W1968191029', 'https://openalex.org/W1971513938', 'https://openalex.org/W1983118095', 'https://openalex.org/W2006644482', 'https://openalex.org/W2006974408', 'https://openalex.org/W2007967180', 'https://openalex.org/W2008286529', 'https://openalex.org/W2009858196', 'https://openalex.org/W2011958490', 'https://openalex.org/W2018986030', 'https://openalex.org/W2019306159', 'https://openalex.org/W2021872392', 'https://openalex.org/W2022463947', 'https://openalex.org/W2031426306', 'https://openalex.org/W2036748250', 'https://openalex.org/W2037829106', 'https://openalex.org/W2039250788', 'https://openalex.org/W2039539582', 'https://openalex.org/W2052925164', 'https://openalex.org/W2054829418', 'https://openalex.org/W2057800506', 'https://openalex.org/W2062891364', 'https://openalex.org/W2069480381', 'https://openalex.org/W2074689515', 'https://openalex.org/W2079436617', 'https://openalex.org/W2082804431', 'https://openalex.org/W2087345361', 'https://openalex.org/W2090851494', 'https://openalex.org/W2109530280', 'https://openalex.org/W2113830209', 'https://openalex.org/W2114464891', 'https://openalex.org/W2136472480', 'https://openalex.org/W2138874471', 'https://openalex.org/W2146393360', 'https://openalex.org/W2149429360', 'https://openalex.org/W2156445661', 'https://openalex.org/W2158240950', 'https://openalex.org/W2162105640', 'https://openalex.org/W2447587', 'https://openalex.org/W68169567'], 'related_works': ['https://openalex.org/W4386335993', 'https://openalex.org/W4310943906', 'https://openalex.org/W4308352595', 'https://openalex.org/W325264682', 'https://openalex.org/W3212117736', 'https://openalex.org/W2909814037', 'https://openalex.org/W2620300421', 'https://openalex.org/W2068005011', 'https://openalex.org/W2034505552', 'https://openalex.org/W2000200648'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2034505552', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-12-14T01:29:26.076998', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
