Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2034468196', 'doi': 'https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<492::aid-cncr30>3.0.co;2-i', 'title': 'Functional insulin receptors are overexpressed in thyroid tumors', 'display_name': 'Functional insulin receptors are overexpressed in thyroid tumors', 'publication_year': 1999, 'publication_date': '1999-01-15', 'ids': {'openalex': 'https://openalex.org/W2034468196', 'doi': 'https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<492::aid-cncr30>3.0.co;2-i', 'mag': '2034468196', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10023720'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<492::aid-cncr30>3.0.co;2-i', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078176024', 'display_name': 'Lucia Frittitta', 'orcid': 'https://orcid.org/0000-0002-7941-5828'}, 'institutions': [{'id': 'https://openalex.org/I4210105999', 'display_name': 'Ospedale Garibaldi', 'ror': 'https://ror.org/01q6hrg49', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105999']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Lucia Frittitta', 'raw_affiliation_strings': ['Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy', 'institution_ids': ['https://openalex.org/I4210105999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044077925', 'display_name': 'Laura Sciacca', 'orcid': 'https://orcid.org/0000-0002-3258-7200'}, 'institutions': [{'id': 'https://openalex.org/I4210105999', 'display_name': 'Ospedale Garibaldi', 'ror': 'https://ror.org/01q6hrg49', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105999']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Laura Sciacca', 'raw_affiliation_strings': ['Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy', 'institution_ids': ['https://openalex.org/I4210105999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030784023', 'display_name': 'Rosaria Catalfamo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105999', 'display_name': 'Ospedale Garibaldi', 'ror': 'https://ror.org/01q6hrg49', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105999']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Rosaria Catalfamo', 'raw_affiliation_strings': ['Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy', 'institution_ids': ['https://openalex.org/I4210105999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057664702', 'display_name': 'A Ippolito', 'orcid': 'https://orcid.org/0000-0003-2135-5209'}, 'institutions': [{'id': 'https://openalex.org/I4210105999', 'display_name': 'Ospedale Garibaldi', 'ror': 'https://ror.org/01q6hrg49', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105999']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Antonio Ippolito', 'raw_affiliation_strings': ['Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy', 'institution_ids': ['https://openalex.org/I4210105999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083453181', 'display_name': 'Pietro Gangemi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210160210', 'display_name': 'Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele', 'ror': 'https://ror.org/051tt6c85', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160210']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Pietro Gangemi', 'raw_affiliation_strings': ['Servizio di Anatomia Patologica, Ospedale Vittorio Emanuele II, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Servizio di Anatomia Patologica, Ospedale Vittorio Emanuele II, Catania, Italy', 'institution_ids': ['https://openalex.org/I4210160210']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044464899', 'display_name': 'V. Pezzino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105999', 'display_name': 'Ospedale Garibaldi', 'ror': 'https://ror.org/01q6hrg49', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105999']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Vincenzo Pezzino', 'raw_affiliation_strings': ['Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy', 'institution_ids': ['https://openalex.org/I4210105999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027823950', 'display_name': 'Sébastiano Filetti', 'orcid': 'https://orcid.org/0000-0001-8570-6448'}, 'institutions': [{'id': 'https://openalex.org/I4210133461', 'display_name': 'Azienda Ospedaliero Universitario Mater Domini', 'ror': 'https://ror.org/03q658t19', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133461']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Sebastiano Filetti', 'raw_affiliation_strings': ['Dipartimento di Medicina Sperimentale e Clinica, Cattedra di Endocrinologia, Università degli Studi di Reggio Calabria, Policlinico Mater Domini, Catanzaro, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Medicina Sperimentale e Clinica, Cattedra di Endocrinologia, Università degli Studi di Reggio Calabria, Policlinico Mater Domini, Catanzaro, Italy', 'institution_ids': ['https://openalex.org/I4210133461']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019197295', 'display_name': 'Riccardo Vigneri', 'orcid': 'https://orcid.org/0000-0002-4401-3140'}, 'institutions': [{'id': 'https://openalex.org/I4210105999', 'display_name': 'Ospedale Garibaldi', 'ror': 'https://ror.org/01q6hrg49', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105999']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Riccardo Vigneri', 'raw_affiliation_strings': ['Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Università di Catania, Ospedale Garibaldi, Catania, Italy', 'institution_ids': ['https://openalex.org/I4210105999']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4740, 'currency': 'USD', 'value_usd': 4740, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.203, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.893285, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '85', 'issue': '2', 'first_page': '492', 'last_page': '498'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10329', 'display_name': 'Management and Diagnosis of Thyroid Cancer', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10329', 'display_name': 'Management and Diagnosis of Thyroid Cancer', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10293', 'display_name': 'Thyroid Disease and Hormone Regulation', 'score': 0.9595, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/immunostaining', 'display_name': 'Immunostaining', 'score': 0.7159698}, {'id': 'https://openalex.org/keywords/thyroid-hormone', 'display_name': 'Thyroid Hormone', 'score': 0.547434}, {'id': 'https://openalex.org/keywords/thyroid-nodules', 'display_name': 'Thyroid Nodules', 'score': 0.543202}, {'id': 'https://openalex.org/keywords/thyroid-carcinoma', 'display_name': 'Thyroid Carcinoma', 'score': 0.537266}, {'id': 'https://openalex.org/keywords/thyroid-antibodies', 'display_name': 'Thyroid Antibodies', 'score': 0.517645}, {'id': 'https://openalex.org/keywords/follicular-cell', 'display_name': 'Follicular cell', 'score': 0.50575376}, {'id': 'https://openalex.org/keywords/hyperthyroidism', 'display_name': 'Hyperthyroidism', 'score': 0.502029}], 'concepts': [{'id': 'https://openalex.org/C526584372', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Thyroid', 'level': 2, 'score': 0.7826998}, {'id': 'https://openalex.org/C4224716', 'wikidata': 'https://www.wikidata.org/wiki/Q10859258', 'display_name': 'Immunostaining', 'level': 3, 'score': 0.7159698}, {'id': 'https://openalex.org/C2993294228', 'wikidata': 'https://www.wikidata.org/wiki/Q13632630', 'display_name': 'Thyroid carcinoma', 'level': 3, 'score': 0.64923275}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6476343}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.64665765}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.61730623}, {'id': 'https://openalex.org/C2777428134', 'wikidata': 'https://www.wikidata.org/wiki/Q272741', 'display_name': 'Adenoma', 'level': 2, 'score': 0.6027242}, {'id': 'https://openalex.org/C187785154', 'wikidata': 'https://www.wikidata.org/wiki/Q5464664', 'display_name': 'Follicular phase', 'level': 2, 'score': 0.5632318}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.513368}, {'id': 'https://openalex.org/C2778057883', 'wikidata': 'https://www.wikidata.org/wiki/Q92793969', 'display_name': 'Follicular cell', 'level': 3, 'score': 0.50575376}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.42415178}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.3966135}], 'mesh': [{'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011863', 'descriptor_name': 'Radioimmunoassay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013961', 'descriptor_name': 'Thyroid Gland', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013961', 'descriptor_name': 'Thyroid Gland', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<492::aid-cncr30>3.0.co;2-i', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10023720', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.61, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1543679567', 'https://openalex.org/W1552044089', 'https://openalex.org/W1597344889', 'https://openalex.org/W1819609506', 'https://openalex.org/W1829756367', 'https://openalex.org/W1969068462', 'https://openalex.org/W1974513412', 'https://openalex.org/W1977779461', 'https://openalex.org/W1984532045', 'https://openalex.org/W1989537052', 'https://openalex.org/W1990141535', 'https://openalex.org/W1991710558', 'https://openalex.org/W2007312325', 'https://openalex.org/W2013332593', 'https://openalex.org/W2023966672', 'https://openalex.org/W2042306382', 'https://openalex.org/W2069909944', 'https://openalex.org/W2080240500', 'https://openalex.org/W2082122684', 'https://openalex.org/W2086437720', 'https://openalex.org/W2087823365', 'https://openalex.org/W2089602144', 'https://openalex.org/W2094280872', 'https://openalex.org/W2095429990', 'https://openalex.org/W2101791531', 'https://openalex.org/W2108837101', 'https://openalex.org/W2143427348', 'https://openalex.org/W2145876884', 'https://openalex.org/W2148932752', 'https://openalex.org/W2315953331', 'https://openalex.org/W2336219024', 'https://openalex.org/W2398613706', 'https://openalex.org/W2408477745', 'https://openalex.org/W2417219239', 'https://openalex.org/W2475271780'], 'related_works': ['https://openalex.org/W4321252293', 'https://openalex.org/W4310464638', 'https://openalex.org/W3033866914', 'https://openalex.org/W2419670328', 'https://openalex.org/W2413230092', 'https://openalex.org/W2368039240', 'https://openalex.org/W2334682124', 'https://openalex.org/W2277594173', 'https://openalex.org/W1986867960', 'https://openalex.org/W1971441377'], 'abstract_inverted_index': {'BACKGROUND': [0], 'Insulin': [1], 'receptor': [2, 8], '(IR),': [3], 'a': [4, 41, 81, 200, 306], 'member': [5], 'of': [6, 199], 'the': [7, 55, 101, 111, 119, 136, 176, 279, 288], 'tyrosine': [9], 'kinase': [10], 'family,': [11], 'is': [12, 229, 243, 275, 284], 'expressed': [13], 'in': [14, 31, 58, 68, 80, 89, 93, 110, 147, 175, 204, 209, 231, 246, 255, 287], 'normal': [15, 61, 114, 149, 178], 'thyroid': [16, 20, 35, 62, 69, 84, 115, 179, 210, 237, 280, 297, 312], 'cells': [17, 92], 'and': [18, 23, 33, 47, 88, 162, 188, 208, 217, 234, 239], 'affects': [19], 'cell': [21, 85], 'proliferation': [22], 'differentiation.': [24], 'METHODS': [25], 'The': [26, 49, 197, 221], 'authors': [27], 'measured': [28], 'IR': [29, 56, 66, 103, 138, 166, 202, 227, 241, 273], 'content': [30, 57, 104, 139, 167, 203, 228, 242], 'benign': [32, 131, 205, 248], 'malignant': [34, 281], 'tumors': [36], 'by': [37, 214], 'three': [38], 'independent': [39], 'methods:': [40], 'specific': [42], 'radioimmunoassay,': [43], '125I-insulin': [44], 'binding': [45, 216], 'studies,': [46], 'immunohistochemistry.': [48], 'results': [50], 'obtained': [51], 'were': [52], 'compared': [53], 'with': [54], 'paired,': [59], 'adjacent,': [60], 'tissue.': [63], 'To': [64], 'assess': [65], 'function': [67], 'carcinoma': [70, 91], 'cells,': [71], 'glucose': [72], 'uptake': [73], 'responsiveness': [74], 'to': [75, 107, 278, 296, 310], 'insulin': [76], 'was': [77, 105, 140, 168, 212], 'also': [78, 244], 'studied': [79], 'human': [82], 'transformed': [83, 311], 'line': [86], '(B-CPAP)': [87], 'follicular': [90, 164, 233, 249, 259], 'primary': [94], 'culture.': [95], 'RESULTS': [96], 'In': [97, 129, 159], '9': [98, 112], 'toxic': [99], 'adenomas,': [100, 135], 'average': [102, 137], 'similar': [106], 'that': [108, 225, 271, 304], 'observed': [109], 'paired': [113, 148], 'tissue': [116, 150, 180], 'specimens': [117, 151], 'from': [118], 'same': [120], 'patients': [121], '(2.2': [122], '±': [123, 127, 153, 157, 182, 186, 190, 194], '0.3': [124], 'vs.': [125, 155, 184, 192], '2.1': [126], '0.3).': [128], '13': [130], 'nonfunctioning,': [132], 'or': [133], '"cold,"': [134], 'significantly': [141, 169], 'higher': [142, 170, 201], '(P': [143, 171], '<': [144, 172], '0.001)': [145, 173], 'than': [146, 174], '(4.3': [152], '0.5': [154], '1.8': [156, 193], '0.1).': [158], '12': [160], 'papillary': [161, 235], '10': [163], 'carcinomas,': [165], 'adjacent': [177], '(4.0': [181], '0.4': [183], '1.6': [185], '0.2': [187], '5.6': [189], '1.0': [191], '0.2,': [195], 'respectively).': [196], 'finding': [198], '"cold"': [206, 290], 'adenomas': [207, 250, 260], 'carcinomas': [211], 'confirmed': [213], 'both': [215], 'immunostaining': [218], 'studies.': [219], 'CONCLUSIONS': [220], 'current': [222], 'studies': [223], 'indicate': [224], '1)': [226], 'elevated': [230, 245], 'most': [232, 247], 'differentiated': [236], 'carinomas,': [238], '2)': [240], '("cold"': [251], 'nodules)': [252], 'but': [253, 283], 'not': [254, 276], 'highly': [256], 'differentiated,': [257], 'hyperfunctioning': [258], '("hot"': [261], 'nodules),': [262], 'which': [263], 'very': [264], 'rarely': [265], 'become': [266], 'malignant.': [267], 'This': [268], 'observation': [269], 'suggests': [270], 'increased': [272], 'expression': [274], 'restricted': [277], 'phenotype': [282], 'already': [285], 'present': [286], 'premalignant': [289], 'adenomas.': [291], 'It': [292], 'may': [293], 'contribute,': [294], 'therefore,': [295], 'tumorigenesis': [298], 'and/or': [299], 'represent': [300], 'an': [301], 'early': [302], 'event': [303], 'gives': [305], 'selective': [307], 'growth': [308], 'advantage': [309], 'cells.': [313], 'Cancer': [314, 319], '1999;85:492–8.': [315], '©': [316], '1999': [317], 'American': [318], 'Society.': [320]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2034468196', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-24T04:12:42.791780', 'created_date': '2016-06-24'}