Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2034363326', 'doi': 'https://doi.org/10.1161/01.str.31.6.1299', 'title': 'Age-Dependent Association of Apolipoprotein E Genotypes With Stroke Subtypes in a Japanese Rural Population', 'display_name': 'Age-Dependent Association of Apolipoprotein E Genotypes With Stroke Subtypes in a Japanese Rural Population', 'publication_year': 2000, 'publication_date': '2000-06-01', 'ids': {'openalex': 'https://openalex.org/W2034363326', 'doi': 'https://doi.org/10.1161/01.str.31.6.1299', 'mag': '2034363326', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10835448'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.str.31.6.1299', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62532593', 'display_name': 'Stroke', 'issn_l': '0039-2499', 'issn': ['0039-2499', '1524-4628'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1161/01.str.31.6.1299', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018175714', 'display_name': 'Yoshihiro Kokubo', 'orcid': 'https://orcid.org/0000-0002-0705-9449'}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}, {'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshihiro Kokubo', 'raw_affiliation_strings': ['From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).', 'institution_ids': ['https://openalex.org/I125602781', 'https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012021985', 'display_name': 'Anisul Haque Chowdhury', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}, {'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Anisul Haque Chowdhury', 'raw_affiliation_strings': ['From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).', 'institution_ids': ['https://openalex.org/I125602781', 'https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040593689', 'display_name': 'Chigusa Date', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}, {'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Chigusa Date', 'raw_affiliation_strings': ['From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).', 'institution_ids': ['https://openalex.org/I317356780', 'https://openalex.org/I125602781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101465032', 'display_name': 'Tetsuji Yokoyama', 'orcid': 'https://orcid.org/0000-0002-7699-6882'}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}, {'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuji Yokoyama', 'raw_affiliation_strings': ['From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).', 'institution_ids': ['https://openalex.org/I125602781', 'https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074556427', 'display_name': 'Hatiki Sobue', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}, {'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hatiki Sobue', 'raw_affiliation_strings': ['From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).', 'institution_ids': ['https://openalex.org/I125602781', 'https://openalex.org/I317356780']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017097328', 'display_name': 'Heizo Tanaka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}, {'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Heizo Tanaka', 'raw_affiliation_strings': ['From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Physiology, School of Medicine (Y.K.), and Department of Epidemiology, Medical Research Institute (Y.K., A.H.C., T.Y., H.T.), Tokyo Medical and Dental University, Tokyo, Japan; Department of Public Health, Osaka City University Medical School, Osaka, Japan (C.D.); and Hokuetsu Hospital, Shibata City, Niigata, Japan (H.S.).', 'institution_ids': ['https://openalex.org/I125602781', 'https://openalex.org/I317356780']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.332, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 103, 'citation_normalized_percentile': {'value': 0.943034, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '31', 'issue': '6', 'first_page': '1299', 'last_page': '1306'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10394', 'display_name': 'Cholesterol-lowering Treatment', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10394', 'display_name': 'Cholesterol-lowering Treatment', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10027', 'display_name': 'Metabolic Syndrome and Cardiovascular Disease', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10816', 'display_name': 'Diagnosis and Treatment of Carotid Artery Disease', 'score': 0.9887, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/apolipoprotein-e', 'display_name': 'Apolipoprotein E', 'score': 0.80631834}, {'id': 'https://openalex.org/keywords/stroke', 'display_name': 'Stroke (engine)', 'score': 0.5924725}, {'id': 'https://openalex.org/keywords/stroke-prevention', 'display_name': 'Stroke Prevention', 'score': 0.450938}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.92269707}, {'id': 'https://openalex.org/C57089818', 'wikidata': 'https://www.wikidata.org/wiki/Q424728', 'display_name': 'Apolipoprotein E', 'level': 3, 'score': 0.80631834}, {'id': 'https://openalex.org/C2777736543', 'wikidata': 'https://www.wikidata.org/wiki/Q693442', 'display_name': 'Subarachnoid hemorrhage', 'level': 2, 'score': 0.685011}, {'id': 'https://openalex.org/C2777094939', 'wikidata': 'https://www.wikidata.org/wiki/Q1368943', 'display_name': 'Intracerebral hemorrhage', 'level': 3, 'score': 0.66836596}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6612154}, {'id': 'https://openalex.org/C2779450755', 'wikidata': 'https://www.wikidata.org/wiki/Q1209150', 'display_name': 'Cerebral infarction', 'level': 3, 'score': 0.631016}, {'id': 'https://openalex.org/C2780645631', 'wikidata': 'https://www.wikidata.org/wiki/Q671554', 'display_name': 'Stroke (engine)', 'level': 2, 'score': 0.5924725}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.5133373}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.48374343}, {'id': 'https://openalex.org/C2777798775', 'wikidata': 'https://www.wikidata.org/wiki/Q207550', 'display_name': 'Infarction', 'level': 3, 'score': 0.42613384}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.37690148}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.35568267}, {'id': 'https://openalex.org/C500558357', 'wikidata': 'https://www.wikidata.org/wiki/Q12152', 'display_name': 'Myocardial infarction', 'level': 2, 'score': 0.21596682}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.17159888}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0740031}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0404945}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000483', 'descriptor_name': 'Alleles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000367', 'descriptor_name': 'Age Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053329', 'descriptor_name': 'Apolipoprotein E2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053327', 'descriptor_name': 'Apolipoprotein E4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002543', 'descriptor_name': 'Cerebral Hemorrhage', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002543', 'descriptor_name': 'Cerebral Hemorrhage', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D002543', 'descriptor_name': 'Cerebral Hemorrhage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D005787', 'descriptor_name': 'Gene Frequency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020766', 'descriptor_name': 'Intracranial Embolism', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020766', 'descriptor_name': 'Intracranial Embolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020766', 'descriptor_name': 'Intracranial Embolism', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D007564', 'descriptor_name': 'Japan', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D007564', 'descriptor_name': 'Japan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012150', 'descriptor_name': 'Polymorphism, Restriction Fragment Length', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012424', 'descriptor_name': 'Rural Population', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D013345', 'descriptor_name': 'Subarachnoid Hemorrhage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013345', 'descriptor_name': 'Subarachnoid Hemorrhage', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013345', 'descriptor_name': 'Subarachnoid Hemorrhage', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.str.31.6.1299', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62532593', 'display_name': 'Stroke', 'issn_l': '0039-2499', 'issn': ['0039-2499', '1524-4628'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10835448', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.str.31.6.1299', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62532593', 'display_name': 'Stroke', 'issn_l': '0039-2499', 'issn': ['0039-2499', '1524-4628'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.64, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1577502861', 'https://openalex.org/W171150731', 'https://openalex.org/W1925357517', 'https://openalex.org/W1965364459', 'https://openalex.org/W1966630835', 'https://openalex.org/W1968954730', 'https://openalex.org/W1971304009', 'https://openalex.org/W1975726028', 'https://openalex.org/W1990170200', 'https://openalex.org/W1992169210', 'https://openalex.org/W1993691738', 'https://openalex.org/W1995628201', 'https://openalex.org/W2008661724', 'https://openalex.org/W2010165219', 'https://openalex.org/W2010923817', 'https://openalex.org/W2029877157', 'https://openalex.org/W2035252462', 'https://openalex.org/W2037338720', 'https://openalex.org/W2037780931', 'https://openalex.org/W2039158755', 'https://openalex.org/W2041396523', 'https://openalex.org/W2043993231', 'https://openalex.org/W2048840335', 'https://openalex.org/W2049861972', 'https://openalex.org/W2065215886', 'https://openalex.org/W2066644955', 'https://openalex.org/W2069863984', 'https://openalex.org/W2074014682', 'https://openalex.org/W2077244492', 'https://openalex.org/W2078776879', 'https://openalex.org/W2098945650', 'https://openalex.org/W2101898786', 'https://openalex.org/W2102602118', 'https://openalex.org/W2109568753', 'https://openalex.org/W2111774300', 'https://openalex.org/W2113173732', 'https://openalex.org/W2114935838', 'https://openalex.org/W2124531214', 'https://openalex.org/W2130947021', 'https://openalex.org/W2135633069', 'https://openalex.org/W2138522001', 'https://openalex.org/W2147462207', 'https://openalex.org/W2149804650', 'https://openalex.org/W2150000105', 'https://openalex.org/W2160209091', 'https://openalex.org/W2165820090', 'https://openalex.org/W2165903604', 'https://openalex.org/W2166533761', 'https://openalex.org/W2170166116', 'https://openalex.org/W2332432907', 'https://openalex.org/W2338858604', 'https://openalex.org/W2338943201', 'https://openalex.org/W2405594372', 'https://openalex.org/W2431460825', 'https://openalex.org/W2610686450', 'https://openalex.org/W35562024', 'https://openalex.org/W4241837520'], 'related_works': ['https://openalex.org/W3143906754', 'https://openalex.org/W3029802872', 'https://openalex.org/W3025467163', 'https://openalex.org/W2378475399', 'https://openalex.org/W2375605452', 'https://openalex.org/W2359971972', 'https://openalex.org/W2358730843', 'https://openalex.org/W2245259410', 'https://openalex.org/W2145616679', 'https://openalex.org/W1967121322'], 'abstract_inverted_index': {'Background': [0], 'and': [1, 10, 25, 37, 64, 145, 154, 219, 233, 267, 280, 294], 'Purpose': [2], '—The': [3], 'association': [4, 33, 230], 'between': [5, 34, 231, 292], 'apolipoprotein': [6], 'E': [7], '(apoE)': [8], 'polymorphisms': [9], 'stroke': [11, 24, 38, 234, 286], 'has': [12], 'been': [13], 'controversial.': [14], 'These': [15], 'controversies': [16], 'may': [17, 287], 'be': [18, 288], 'due': [19], 'to': [20, 70, 121, 140, 152, 161, 184, 201, 217, 227, 250], 'inaccurate': [21], 'classification': [22], 'of': [23, 113, 132, 176, 193, 210, 285], 'differences': [26], 'in': [27, 49, 88, 237, 246], 'age': [28, 293], 'ranges.': [29], 'We': [30], 'investigated': [31], 'the': [32, 85, 89], 'apoE': [35, 104, 258, 295], 'genotypes': [36, 93], 'subtypes': [39], '(confirmed': [40], 'by': [41, 46, 96, 290], 'CT': [42], 'or': [43, 242], 'MRI': [44], 'findings)': [45], 'case-control': [47], 'study': [48, 255], 'a': [50, 110, 173, 261, 273], 'Japanese': [51], 'rural': [52], 'population.': [53], 'Methods': [54], '—First-ever-stroke': [55], 'patients': [56], '(n=322;': [57], 'cerebral': [58, 114, 124], 'infarction,': [59], 'n=201,': [60], 'intracerebral': [61, 194, 220, 268, 278], 'hemorrhage,': [62, 66, 269, 279], 'n=84,': [63], 'subarachnoid': [65, 177, 281], 'n=37)': [67], 'aged': [68, 239, 248], '40': [69, 249], '89': [71], 'years': [72, 241], 'were': [73, 82, 94], 'recruited': [74], 'from': [75, 84], 'Hokuetsu': [76], 'Hospital,': [77], 'Japan.': [78], 'Healthy': [79], 'controls': [80], '(n=1126)': [81], 'selected': [83], 'general': [86], 'population': [87], 'same': [90], 'area.': [91], 'ApoE': [92, 169, 186, 203], 'determined': [95], 'restriction': [97], 'fragment-length': [98], 'polymorphism': [99], 'analysis.': [100], 'Results': [101], '—Compared': [102], 'with': [103], 'ε3/ε3': [105], 'subjects,': [106], 'ε2': [107, 127, 232, 259], 'carriers': [108, 128, 171], 'had': [109, 129, 172, 189], '2-fold': [111], 'risk': [112, 175, 192, 209, 262, 274], 'infarction': [115, 125, 134, 166], '(OR': [116, 135, 147, 156, 179, 196, 212, 222], '1.9,': [117], '95%': [118, 137, 149, 158, 181, 198, 214, 224], 'CI': [119, 138, 150, 159, 182, 199, 215, 225], '1.1': [120, 183], '3.2).': [122], 'Among': [123], 'patients,': [126], 'increased': [130, 191, 208], 'risks': [131], 'cortical': [133], '2.4,': [136], '1.3': [139], '4.6)': [141], '(an': [142], 'anatomic': [143], 'subtype)': [144], 'atherothrombosis': [146, 211], '3.9,': [148], '1.7': [151], '9.0)': [153], 'cardioembolism': [155], '4.9,': [157], '1.6': [160], '14.4)': [162], 'but': [163, 244], 'not': [164, 245], 'lacunar': [165], '(clinical': [167], 'subtypes).': [168], 'ε4': [170, 271], '2.5-fold': [174], 'hemorrhage': [178, 195, 221], '2.5,': [180], '5.4).': [185], 'ε2/ε2': [187], 'subjects': [188, 205, 238], 'an': [190], '4.4,': [197], '1.0': [200, 216, 226], '19.7).': [202], 'ε3/ε4': [204], 'showed': [206], '≈2-fold': [207], '2.1,': [213], '4.1)': [218], '1.8,': [223], '3.3).': [228], 'The': [229, 283], 'was': [235], 'accentuated': [236], '70': [240], 'older': [243], 'those': [247], '69': [251], 'years.': [252], 'Conclusions': [253], '—Our': [254], 'suggests': [256], 'that': [257], 'is': [260, 272], 'factor': [263, 275], 'for': [264, 276], 'atherothrombosis,': [265, 277], 'cardioembolism,': [266], 'whereas': [270], 'hemorrhage.': [282], 'occurrence': [284], 'affected': [289], 'interaction': [291], 'gene': [296], 'polymorphisms.': [297]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2034363326', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-09-09T09:23:22.436681', 'created_date': '2016-06-24'}