Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2034225514', 'doi': 'https://doi.org/10.1001/jama.1989.03430130102042', 'title': 'The Family of Protein Kinase C for Signal Transduction', 'display_name': 'The Family of Protein Kinase C for Signal Transduction', 'publication_year': 1989, 'publication_date': '1989-10-06', 'ids': {'openalex': 'https://openalex.org/W2034225514', 'doi': 'https://doi.org/10.1001/jama.1989.03430130102042', 'mag': '2034225514', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2674488'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1001/jama.1989.03430130102042', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S172573765', 'display_name': 'JAMA', 'issn_l': '0098-7484', 'issn': ['0098-7484', '1538-3598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5006534769', 'display_name': 'Yasutomi Nishizuka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yasutomi Nishizuka', 'raw_affiliation_strings': ['Dept. of Biochemistry, Kobe University School of Medicine, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Biochemistry, Kobe University School of Medicine, Japan.', 'institution_ids': ['https://openalex.org/I65837984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5006534769'], 'corresponding_institution_ids': ['https://openalex.org/I65837984'], 'apc_list': None, 'apc_paid': None, 'fwci': 17.295, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 383, 'citation_normalized_percentile': {'value': 0.89842, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '262', 'issue': '13', 'first_page': '1826', 'last_page': '1826'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9835, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9835, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11353', 'display_name': 'Venomous Animal Envenomation and Studies', 'score': 0.9076, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 0.9056, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/prkcq', 'display_name': 'PRKCQ', 'score': 0.5339761}, {'id': 'https://openalex.org/keywords/cell-surface-receptor', 'display_name': 'Cell surface receptor', 'score': 0.4232096}], 'concepts': [{'id': 'https://openalex.org/C36020004', 'wikidata': 'https://www.wikidata.org/wiki/Q106951674', 'display_name': 'Diacylglycerol kinase', 'level': 4, 'score': 0.72799957}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.71585226}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.6645418}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.53593034}, {'id': 'https://openalex.org/C186518008', 'wikidata': 'https://www.wikidata.org/wiki/Q18030780', 'display_name': 'PRKCQ', 'level': 5, 'score': 0.5339761}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.46325147}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.45439273}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.430167}, {'id': 'https://openalex.org/C197462201', 'wikidata': 'https://www.wikidata.org/wiki/Q2476074', 'display_name': 'Cell surface receptor', 'level': 3, 'score': 0.4232096}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40847585}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.38346338}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.2598359}, {'id': 'https://openalex.org/C90934575', 'wikidata': 'https://www.wikidata.org/wiki/Q6593810', 'display_name': 'Mitogen-activated protein kinase kinase', 'level': 4, 'score': 0.25277743}], 'mesh': [{'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001363', 'descriptor_name': 'Awards and Prizes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001669', 'descriptor_name': 'Biochemical Phenomena', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001671', 'descriptor_name': 'Biochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1001/jama.1989.03430130102042', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S172573765', 'display_name': 'JAMA', 'issn_l': '0098-7484', 'issn': ['0098-7484', '1538-3598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2674488', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1480686961', 'https://openalex.org/W1481123143', 'https://openalex.org/W1488599557', 'https://openalex.org/W1491958169', 'https://openalex.org/W1509419867', 'https://openalex.org/W1538989554', 'https://openalex.org/W1551828147', 'https://openalex.org/W1594758412', 'https://openalex.org/W1615050047', 'https://openalex.org/W1650137855', 'https://openalex.org/W1895861480', 'https://openalex.org/W1915389640', 'https://openalex.org/W1929472049', 'https://openalex.org/W1935820490', 'https://openalex.org/W1964839077', 'https://openalex.org/W1970441944', 'https://openalex.org/W1970991463', 'https://openalex.org/W1973261169', 'https://openalex.org/W1977525265', 'https://openalex.org/W1982152509', 'https://openalex.org/W1987050549', 'https://openalex.org/W1993282564', 'https://openalex.org/W2001668713', 'https://openalex.org/W2001692359', 'https://openalex.org/W2002468039', 'https://openalex.org/W2002522066', 'https://openalex.org/W2004047501', 'https://openalex.org/W2007096194', 'https://openalex.org/W2009856702', 'https://openalex.org/W2010146168', 'https://openalex.org/W2012861970', 'https://openalex.org/W2014969594', 'https://openalex.org/W2021253208', 'https://openalex.org/W2022342758', 'https://openalex.org/W2027879757', 'https://openalex.org/W2035985010', 'https://openalex.org/W2036979250', 'https://openalex.org/W2051884276', 'https://openalex.org/W2058387837', 'https://openalex.org/W2059421144', 'https://openalex.org/W2063731517', 'https://openalex.org/W2068877244', 'https://openalex.org/W2072099683', 'https://openalex.org/W2072436875', 'https://openalex.org/W2072545895', 'https://openalex.org/W2073478078', 'https://openalex.org/W2074416628', 'https://openalex.org/W2075563497', 'https://openalex.org/W2077088537', 'https://openalex.org/W2077298935', 'https://openalex.org/W2078157295', 'https://openalex.org/W2080268027', 'https://openalex.org/W2087236026', 'https://openalex.org/W2088072731', 'https://openalex.org/W2112717683', 'https://openalex.org/W2151335002', 'https://openalex.org/W2196524012', 'https://openalex.org/W2410473994', 'https://openalex.org/W3102875255', 'https://openalex.org/W579517773'], 'related_works': ['https://openalex.org/W36220733', 'https://openalex.org/W3204563845', 'https://openalex.org/W2423035669', 'https://openalex.org/W2417491548', 'https://openalex.org/W2410295749', 'https://openalex.org/W2401833520', 'https://openalex.org/W2091930564', 'https://openalex.org/W2077166985', 'https://openalex.org/W2055870423', 'https://openalex.org/W2018397114'], 'abstract_inverted_index': {'Protein': [0], 'kinase': [1, 74, 100], 'C,': [2], 'an': [3], 'enzyme': [4, 37], 'that': [5, 72, 86, 97], 'is': [6, 76], 'activated': [7], 'by': [8], 'diacylglycerol': [9], 'resulting': [10], 'from': [11, 57], 'the': [12, 27, 61, 83, 98, 120, 126, 140, 146], 'receptor-mediated': [13], 'hydrolysis': [14], 'of': [15, 20, 23, 49, 63, 80, 119, 128, 142, 148], 'inositol': [16], 'phospholipids,': [17], 'relays': [18], 'information': [19], 'a': [21, 41, 47, 77], 'variety': [22], 'extracellular': [24], 'signals': [25], 'across': [26], 'cell': [28, 109], 'membrane': [29, 143], 'to': [30, 134], 'regulate': [31], 'many': [32], 'intracellular': [33, 114], 'processes.': [34], 'Since': [35], 'this': [36], 'also': [38], 'serves': [39], 'as': [40, 138], 'major': [42], 'receptor': [43], 'for': [44], 'phorbol': [45], 'esters,': [46], 'class': [48], 'tumor': [50], 'promoters,': [51], 'it': [52], 'has': [53, 70], 'attracted': [54], 'great': [55], 'attention': [56], 'biologists': [58], 'interested': [59], 'in': [60, 107, 125, 139], 'mechanism': [62], 'signal': [64], 'transduction': [65], 'and': [66, 93, 111, 131, 145], 'carcinogenesis.': [67], 'Recent': [68], 'analysis': [69], 'revealed': [71], 'protein': [73, 99], 'C': [75, 101], 'large': [78], 'family': [79, 121], 'proteins,': [81], 'with': [82, 112], 'multiple': [84], 'subspecies': [85, 102], 'possess': [87], 'subtle': [88], 'individual': [89], 'enzymological': [90], 'characteristics.': [91], 'Biochemical': [92], 'immunohistochemical': [94], 'studies': [95], 'indicate': [96], 'may': [103], 'be': [104], 'differently': [105], 'distributed': [106], 'particular': [108], 'types': [110], 'limited': [113], 'locations.': [115], 'Presumably,': [116], 'each': [117], 'member': [118], 'plays': [122], 'discrete': [123], 'roles': [124], 'processing': [127], 'various': [129], 'physiological': [130], 'pathological': [132], 'responses': [133], 'external': [135], 'signals,': [136], 'such': [137], 'modulation': [141], 'functions': [144], 'activation': [147], 'gene': [149], 'transcription.': [150]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2034225514', 'counts_by_year': [{'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-11T11:47:37.973149', 'created_date': '2016-06-24'}