Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2034225154', 'doi': 'https://doi.org/10.1016/j.ejphar.2007.03.022', 'title': 'Impaired arginine–vasopressin-induced aldosterone release from adrenal gland cells in mice lacking the vasopressin V1A receptor', 'display_name': 'Impaired arginine–vasopressin-induced aldosterone release from adrenal gland cells in mice lacking the vasopressin V1A receptor', 'publication_year': 2007, 'publication_date': '2007-07-01', 'ids': {'openalex': 'https://openalex.org/W2034225154', 'doi': 'https://doi.org/10.1016/j.ejphar.2007.03.022', 'mag': '2034225154', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17449028'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejphar.2007.03.022', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013963265', 'display_name': 'Jun‐ichi Birumachi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210132193', 'display_name': 'National Center For Child Health and Development', 'ror': 'https://ror.org/03fvwxc59', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210132193']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Jun-ichi Birumachi', 'raw_affiliation_strings': ['Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.', 'institution_ids': ['https://openalex.org/I4210132193']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001561113', 'display_name': 'Masami Hiroyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210132193', 'display_name': 'National Center For Child Health and Development', 'ror': 'https://ror.org/03fvwxc59', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210132193']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masami Hiroyama', 'raw_affiliation_strings': ['Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.', 'institution_ids': ['https://openalex.org/I4210132193']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011811795', 'display_name': 'Yoko Fujiwara', 'orcid': 'https://orcid.org/0000-0002-7557-2383'}, 'institutions': [{'id': 'https://openalex.org/I4210132193', 'display_name': 'National Center For Child Health and Development', 'ror': 'https://ror.org/03fvwxc59', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210132193']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoko Fujiwara', 'raw_affiliation_strings': ['Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.', 'institution_ids': ['https://openalex.org/I4210132193']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085135478', 'display_name': 'Toshinori Aoyagi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210132193', 'display_name': 'National Center For Child Health and Development', 'ror': 'https://ror.org/03fvwxc59', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210132193']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshinori Aoyagi', 'raw_affiliation_strings': ['Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.', 'institution_ids': ['https://openalex.org/I4210132193']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065491742', 'display_name': 'Atsushi Sanbe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210132193', 'display_name': 'National Center For Child Health and Development', 'ror': 'https://ror.org/03fvwxc59', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210132193']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Atsushi Sanbe', 'raw_affiliation_strings': ['Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.', 'institution_ids': ['https://openalex.org/I4210132193']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062372400', 'display_name': 'Akito Tanoue', 'orcid': 'https://orcid.org/0000-0001-5721-0664'}, 'institutions': [{'id': 'https://openalex.org/I4210132193', 'display_name': 'National Center For Child Health and Development', 'ror': 'https://ror.org/03fvwxc59', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210132193']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akito Tanoue', 'raw_affiliation_strings': ['Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, National Research Institute for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535, Japan.', 'institution_ids': ['https://openalex.org/I4210132193']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2790, 'currency': 'USD', 'value_usd': 2790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.457, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.832416, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '566', 'issue': '1-3', 'first_page': '226', 'last_page': '230'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11541', 'display_name': 'Oxytocin and Social Behavior Regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/3207', 'display_name': 'Social Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11541', 'display_name': 'Oxytocin and Social Behavior Regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/3207', 'display_name': 'Social Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}, {'id': 'https://openalex.org/T10342', 'display_name': 'Mammalian Circadian Rhythms and Physiology', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10529', 'display_name': 'Effects of Stress on Brain Function and Health', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/2802', 'display_name': 'Behavioral Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vasopressin', 'display_name': 'Vasopressin', 'score': 0.488201}, {'id': 'https://openalex.org/keywords/acth-receptor', 'display_name': 'ACTH receptor', 'score': 0.47790346}, {'id': 'https://openalex.org/keywords/mineralocorticoid', 'display_name': 'Mineralocorticoid', 'score': 0.42783672}], 'concepts': [{'id': 'https://openalex.org/C2776370428', 'wikidata': 'https://www.wikidata.org/wiki/Q21124841', 'display_name': 'Vasopressin', 'level': 2, 'score': 0.9128165}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.8883879}, {'id': 'https://openalex.org/C2778525890', 'wikidata': 'https://www.wikidata.org/wiki/Q184564', 'display_name': 'Aldosterone', 'level': 2, 'score': 0.8847286}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.88419795}, {'id': 'https://openalex.org/C2780694816', 'wikidata': 'https://www.wikidata.org/wiki/Q712294', 'display_name': 'Adrenal gland', 'level': 2, 'score': 0.6498321}, {'id': 'https://openalex.org/C2780546910', 'wikidata': 'https://www.wikidata.org/wiki/Q185690', 'display_name': 'Adrenocorticotropic hormone', 'level': 3, 'score': 0.63749397}, {'id': 'https://openalex.org/C2777468819', 'wikidata': 'https://www.wikidata.org/wiki/Q173670', 'display_name': 'Arginine', 'level': 3, 'score': 0.611473}, {'id': 'https://openalex.org/C20352681', 'wikidata': 'https://www.wikidata.org/wiki/Q14890035', 'display_name': 'Arginine vasopressin receptor 2', 'level': 4, 'score': 0.5945145}, {'id': 'https://openalex.org/C90277851', 'wikidata': 'https://www.wikidata.org/wiki/Q14890030', 'display_name': 'Arginine vasopressin receptor 1B', 'level': 5, 'score': 0.5935221}, {'id': 'https://openalex.org/C90474776', 'wikidata': 'https://www.wikidata.org/wiki/Q24784390', 'display_name': 'Vasopressin receptor', 'level': 4, 'score': 0.5780323}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4955598}, {'id': 'https://openalex.org/C177865409', 'wikidata': 'https://www.wikidata.org/wiki/Q410784', 'display_name': 'ACTH receptor', 'level': 4, 'score': 0.47790346}, {'id': 'https://openalex.org/C2776069600', 'wikidata': 'https://www.wikidata.org/wiki/Q422519', 'display_name': 'Mineralocorticoid', 'level': 3, 'score': 0.42783672}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38398618}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.35644054}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.35132563}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2653981}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.07771927}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.036860406}], 'mesh': [{'descriptor_ui': 'D000311', 'descriptor_name': 'Adrenal Glands', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000450', 'descriptor_name': 'Aldosterone', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D001127', 'descriptor_name': 'Arginine Vasopressin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017483', 'descriptor_name': 'Receptors, Vasopressin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000311', 'descriptor_name': 'Adrenal Glands', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D000311', 'descriptor_name': 'Adrenal Glands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000324', 'descriptor_name': 'Adrenocorticotropic Hormone', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000324', 'descriptor_name': 'Adrenocorticotropic Hormone', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D000324', 'descriptor_name': 'Adrenocorticotropic Hormone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000324', 'descriptor_name': 'Adrenocorticotropic Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000450', 'descriptor_name': 'Aldosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001127', 'descriptor_name': 'Arginine Vasopressin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017483', 'descriptor_name': 'Receptors, Vasopressin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017483', 'descriptor_name': 'Receptors, Vasopressin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejphar.2007.03.022', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17449028', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1591607668', 'https://openalex.org/W1964228140', 'https://openalex.org/W1965484467', 'https://openalex.org/W1967719516', 'https://openalex.org/W1995228102', 'https://openalex.org/W2003367060', 'https://openalex.org/W2028344445', 'https://openalex.org/W2090912797', 'https://openalex.org/W2093275822', 'https://openalex.org/W2102519244', 'https://openalex.org/W2112225287', 'https://openalex.org/W2123170730', 'https://openalex.org/W2126409454', 'https://openalex.org/W2128253171', 'https://openalex.org/W2129927354', 'https://openalex.org/W2158529933', 'https://openalex.org/W2160659224', 'https://openalex.org/W4233412749', 'https://openalex.org/W4241283205', 'https://openalex.org/W4244984390', 'https://openalex.org/W4252014364', 'https://openalex.org/W4252249244', 'https://openalex.org/W657844461'], 'related_works': ['https://openalex.org/W2914284636', 'https://openalex.org/W2334670702', 'https://openalex.org/W2077939764', 'https://openalex.org/W2062690991', 'https://openalex.org/W2034225154', 'https://openalex.org/W2033116575', 'https://openalex.org/W2032593795', 'https://openalex.org/W2007102871', 'https://openalex.org/W1996846474', 'https://openalex.org/W1965336325'], 'abstract_inverted_index': {'We': [0], 'examined': [1], 'aldosterone': [2, 21, 44, 64, 90, 99], 'release': [3, 22, 45, 65, 100], 'in': [4, 20, 48, 66, 75, 112], 'response': [5], 'to': [6, 38], 'stimulation': [7], 'with': [8], 'arginine-vasopressin': [9], '(AVP)': [10], 'using': [11], 'adrenal': [12, 26, 49, 102], 'gland': [13, 27, 50, 103], 'cells.': [14], 'AVP': [15], 'caused': [16], 'a': [17, 80], 'significant': [18], 'increase': [19], 'from': [23, 35, 52, 73, 101], 'the': [24, 55, 108], 'dispersed': [25], 'cells': [28, 51, 104], 'of': [29], 'wild-type': [30], 'mice': [31, 53, 68], '(V1AR+/+)': [32], 'at': [33], 'concentrations': [34], '0.1': [36], 'microM': [37], '1': [39], 'microM.': [40], 'In': [41, 78], 'contrast,': [42], 'AVP-induced': [43, 89, 98], 'was': [46, 69], 'impaired': [47], 'lacking': [54], 'vasopressin': [56, 81, 109], 'V1A': [57, 82, 110], 'receptor': [58, 111], '(V1AR-/-),': [59], 'while': [60], 'adrenocorticotropic': [61], 'hormone': [62], '(ACTH)-induced': [63], 'V1AR-/-': [67], 'not': [70], 'significantly': [71], 'different': [72], 'that': [74, 97], 'V1AR+/+': [76], 'mice.': [77, 113], 'addition,': [79], 'receptor-selective': [83], 'antagonist': [84], '1-[1-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydro-2(1H)-quinolinone': [85], '(OPC-21268)': [86], 'potently': [87], 'inhibited': [88], 'release.': [91], 'Thus,': [92], 'our': [93], 'study': [94], 'clearly': [95], 'demonstrates': [96], 'is': [105], 'mediated': [106], 'via': [107]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2034225154', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-31T18:32:21.529282', 'created_date': '2016-06-24'}