Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2033990363', 'doi': 'https://doi.org/10.1073/pnas.91.5.1868', 'title': 'Direct demonstration of three different states of thepancreatic cholecystokinin receptor.', 'display_name': 'Direct demonstration of three different states of thepancreatic cholecystokinin receptor.', 'publication_year': 1994, 'publication_date': '1994-03-01', 'ids': {'openalex': 'https://openalex.org/W2033990363', 'doi': 'https://doi.org/10.1073/pnas.91.5.1868', 'mag': '2033990363', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8127897', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/43265'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.91.5.1868', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43265', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111716774', 'display_name': 'Venugopal D. Talkad', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}, {'id': 'https://openalex.org/I2802849423', 'display_name': 'University Medical Center', 'ror': 'https://ror.org/036pt7h44', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802849423']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'V D Talkad', 'raw_affiliation_strings': ['Department of Internal Medicine, Saint Louis University Medical Center, MO 63104.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Saint Louis University Medical Center, MO 63104.', 'institution_ids': ['https://openalex.org/I47838141', 'https://openalex.org/I2802849423']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087812067', 'display_name': 'K P Fortune', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K P Fortune', 'raw_affiliation_strings': ['Department of Internal Medicine, Saint Louis University#N#Medical Center, MO 63104.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Saint Louis University#N#Medical Center, MO 63104.', 'institution_ids': ['https://openalex.org/I47838141']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069868133', 'display_name': 'Dale A. Pollo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D A Pollo', 'raw_affiliation_strings': ['Department of Internal Medicine, Saint Louis University#N#Medical Center, MO 63104.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Saint Louis University#N#Medical Center, MO 63104.', 'institution_ids': ['https://openalex.org/I47838141']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110091594', 'display_name': 'G.N. Shah', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G N Shah', 'raw_affiliation_strings': ['Department of Internal Medicine, Saint Louis University#N#Medical Center, MO 63104.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Saint Louis University#N#Medical Center, MO 63104.', 'institution_ids': ['https://openalex.org/I47838141']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020411590', 'display_name': 'Stephen A. Wank', 'orcid': 'https://orcid.org/0000-0002-9608-547X'}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S A Wank', 'raw_affiliation_strings': ['Department of Internal Medicine, Saint Louis University#N#Medical Center, MO 63104.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Saint Louis University#N#Medical Center, MO 63104.', 'institution_ids': ['https://openalex.org/I47838141']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010478795', 'display_name': 'Jerry D. Gardner', 'orcid': 'https://orcid.org/0000-0001-9642-864X'}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J D Gardner', 'raw_affiliation_strings': ['Department of Internal Medicine, Saint Louis University#N#Medical Center, MO 63104.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Saint Louis University#N#Medical Center, MO 63104.', 'institution_ids': ['https://openalex.org/I47838141']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.546, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 54, 'citation_normalized_percentile': {'value': 0.717015, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '91', 'issue': '5', 'first_page': '1868', 'last_page': '1872'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2777593968', 'wikidata': 'https://www.wikidata.org/wiki/Q60315441', 'display_name': 'Cholecystokinin', 'level': 3, 'score': 0.916786}, {'id': 'https://openalex.org/C32110497', 'wikidata': 'https://www.wikidata.org/wiki/Q24788694', 'display_name': 'Cholecystokinin receptor', 'level': 4, 'score': 0.90197253}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.8529051}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.473545}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.44565535}, {'id': 'https://openalex.org/C2778122271', 'wikidata': 'https://www.wikidata.org/wiki/Q410943', 'display_name': 'Receptor antagonist', 'level': 4, 'score': 0.4292574}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.40029827}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.39552653}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3715975}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.34596318}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.34026572}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.29095823}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.07115364}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.052259}], 'mesh': [{'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011949', 'descriptor_name': 'Receptors, Cholecystokinin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001570', 'descriptor_name': 'Benzodiazepinones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001570', 'descriptor_name': 'Benzodiazepinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020109', 'descriptor_name': 'Devazepide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011949', 'descriptor_name': 'Receptors, Cholecystokinin', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D011949', 'descriptor_name': 'Receptors, Cholecystokinin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011949', 'descriptor_name': 'Receptors, Cholecystokinin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012844', 'descriptor_name': 'Sincalide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012844', 'descriptor_name': 'Sincalide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.91.5.1868', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43265', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8127897', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43265', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1578564782', 'https://openalex.org/W1600119213', 'https://openalex.org/W1938887263', 'https://openalex.org/W1965260950', 'https://openalex.org/W1975039464', 'https://openalex.org/W1977779461', 'https://openalex.org/W1979100850', 'https://openalex.org/W1980941762', 'https://openalex.org/W1988646125', 'https://openalex.org/W1994746321', 'https://openalex.org/W1998664134', 'https://openalex.org/W1998750651', 'https://openalex.org/W2010119268', 'https://openalex.org/W2017641419', 'https://openalex.org/W2043813981', 'https://openalex.org/W2050759499', 'https://openalex.org/W2051666919', 'https://openalex.org/W2064604982', 'https://openalex.org/W2084193227', 'https://openalex.org/W2113905013', 'https://openalex.org/W2123652062', 'https://openalex.org/W2143045119', 'https://openalex.org/W2164872793', 'https://openalex.org/W2209036429', 'https://openalex.org/W2302068493', 'https://openalex.org/W2410337980', 'https://openalex.org/W2412677816', 'https://openalex.org/W2416861790', 'https://openalex.org/W2430197908', 'https://openalex.org/W70140158', 'https://openalex.org/W8840807'], 'related_works': ['https://openalex.org/W4238501047', 'https://openalex.org/W2413658046', 'https://openalex.org/W2063662253', 'https://openalex.org/W2043830906', 'https://openalex.org/W2042209138', 'https://openalex.org/W2034906614', 'https://openalex.org/W2031272904', 'https://openalex.org/W2022374429', 'https://openalex.org/W1982594208', 'https://openalex.org/W1977702912'], 'abstract_inverted_index': {'We': [0], 'used': [1], 'rat': [2], 'pancreatic': [3, 14, 42], 'acini': [4, 43], 'as': [5, 7], 'well': [6], 'COS-7': [8], 'cells': [9, 133], 'transfected': [10, 131], 'with': [11, 143], 'the': [12, 20, 51, 59, 70, 75, 99, 111, 120, 125, 140, 144, 148, 152, 155, 169], 'cloned': [13], 'cholecystokinin': [15], '(CCK)': [16], 'receptor': [17, 30, 157, 171], 'and': [18, 26, 39, 69, 90], 'measured': [19], 'abilities': [21], 'of': [22, 35, 50, 58, 66, 74, 82, 98, 106, 119, 124, 139, 154, 168], 'CCK': [23, 29, 52, 126, 141, 156, 170], 'octapeptide': [24], '(CCK-8)': [25], 'L-364,718': [27, 109], '(a': [28], 'antagonist)': [31], 'to': [32, 46, 87, 91, 158], 'inhibit': [33], 'binding': [34], '125I-labeled': [36], 'CCK-8': [37, 65, 81, 105], '(125I-CCK-8)': [38], '[3H]L-364,718.': [40], 'With': [41], '125I-CCK-8': [44], 'bound': [45, 86], 'two': [47], 'different': [48, 122, 137, 162], 'states': [49, 123, 138, 163], 'receptor.': [53, 127], 'The': [54], 'high-affinity': [55], 'state': [56, 72, 96, 146], '(1%': [57], 'receptors)': [60, 76, 100], 'had': [61, 77, 110], 'a': [62, 78, 92, 102], 'Kd': [63, 79, 103], 'for': [64, 80, 104, 117], '985': [67], 'pM': [68], 'low-affinity': [71, 88], '(19%': [73], '30': [83], 'nM.': [84], '[3H]L-364,718': [85], 'receptors': [89], 'previously': [93], 'unrecognized': [94], 'very-low-affinity': [95, 145], '(80%': [97], 'having': [101], '13': [107], 'microM.': [108], 'same': [112], 'affinity': [113], '(Kd': [114], '3': [115], 'nM)': [116], 'each': [118], 'three': [121, 136, 161], 'Similar': [128], 'measurements': [129], 'using': [130], 'COS': [132], 'also': [134], 'identified': [135], 'receptor,': [142], 'being': [147], 'most': [149], 'abundant.': [150], 'Thus,': [151], 'ability': [153], 'exist': [159], 'in': [160], 'is': [164], 'an': [165], 'intrinsic': [166], 'property': [167], 'molecule': [172], 'itself.': [173]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2033990363', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-08T17:48:13.750828', 'created_date': '2016-06-24'}