Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2033982645', 'doi': 'https://doi.org/10.2174/092986711796011292', 'title': 'Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain', 'display_name': 'Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain', 'publication_year': 2011, 'publication_date': '2011-06-01', 'ids': {'openalex': 'https://openalex.org/W2033982645', 'doi': 'https://doi.org/10.2174/092986711796011292', 'mag': '2033982645', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21649580', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4091980'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/092986711796011292', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33159018', 'display_name': 'Current Medicinal Chemistry', 'issn_l': '0929-8673', 'issn': ['0929-8673', '1875-533X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc4091980?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018260058', 'display_name': 'Emmanuelle J. Meuillet', 'orcid': 'https://orcid.org/0000-0002-2242-0810'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'E. J. Meuillet', 'raw_affiliation_strings': ['Department of Nutritional Sciences, The University of Arizona, Tucson, Arizona, USA. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Department of Nutritional Sciences, The University of Arizona, Tucson, Arizona, USA. [email protected]', 'institution_ids': ['https://openalex.org/I138006243']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5018260058'], 'corresponding_institution_ids': ['https://openalex.org/I138006243'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.372, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.999692, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '18', 'issue': '18', 'first_page': '2727', 'last_page': '2742'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Nucleotide Metabolism and Enzyme Regulation', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9837, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pleckstrin-homology-domain', 'display_name': 'Pleckstrin homology domain', 'score': 0.9812091}, {'id': 'https://openalex.org/keywords/protein-kinase-domain', 'display_name': 'Protein kinase domain', 'score': 0.6815277}, {'id': 'https://openalex.org/keywords/pi3k/akt-pathway', 'display_name': 'PI3K/AKT pathway', 'score': 0.630428}, {'id': 'https://openalex.org/keywords/akt2', 'display_name': 'AKT2', 'score': 0.57308865}, {'id': 'https://openalex.org/keywords/proto-oncogene-proteins-c-akt', 'display_name': 'Proto-Oncogene Proteins c-akt', 'score': 0.53192014}], 'concepts': [{'id': 'https://openalex.org/C49658373', 'wikidata': 'https://www.wikidata.org/wiki/Q24776397', 'display_name': 'Pleckstrin homology domain', 'level': 3, 'score': 0.9812091}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.87449324}, {'id': 'https://openalex.org/C154137905', 'wikidata': 'https://www.wikidata.org/wiki/Q17816452', 'display_name': 'AKT1', 'level': 4, 'score': 0.7566128}, {'id': 'https://openalex.org/C32619005', 'wikidata': 'https://www.wikidata.org/wiki/Q24768234', 'display_name': 'Protein kinase domain', 'level': 4, 'score': 0.6815277}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.60718197}, {'id': 'https://openalex.org/C88216763', 'wikidata': 'https://www.wikidata.org/wiki/Q4652205', 'display_name': 'AKT2', 'level': 5, 'score': 0.57308865}, {'id': 'https://openalex.org/C166342909', 'wikidata': 'https://www.wikidata.org/wiki/Q845326', 'display_name': 'Allosteric regulation', 'level': 3, 'score': 0.56948584}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.56479716}, {'id': 'https://openalex.org/C2909831755', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Proto-Oncogene Proteins c-akt', 'level': 4, 'score': 0.53192014}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.52358425}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.4692754}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42637944}, {'id': 'https://openalex.org/C2780610907', 'wikidata': 'https://www.wikidata.org/wiki/Q2273248', 'display_name': 'Phosphatidylinositol', 'level': 3, 'score': 0.4252376}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42231408}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3992916}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.32768494}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.12769574}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001798', 'descriptor_name': 'Blood Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001798', 'descriptor_name': 'Blood Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001798', 'descriptor_name': 'Blood Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001798', 'descriptor_name': 'Blood Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004341', 'descriptor_name': 'Drug Evaluation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023421', 'descriptor_name': 'Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/092986711796011292', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33159018', 'display_name': 'Current Medicinal Chemistry', 'issn_l': '0929-8673', 'issn': ['0929-8673', '1875-533X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4091980', 'pdf_url': 'https://europepmc.org/articles/pmc4091980?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091980', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21649580', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4091980', 'pdf_url': 'https://europepmc.org/articles/pmc4091980?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.8}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 156, 'referenced_works': ['https://openalex.org/W11768824', 'https://openalex.org/W154735814', 'https://openalex.org/W1560667802', 'https://openalex.org/W1561013854', 'https://openalex.org/W1562372296', 'https://openalex.org/W1568605582', 'https://openalex.org/W1602490654', 'https://openalex.org/W1617532721', 'https://openalex.org/W1668086213', 'https://openalex.org/W170338738', 'https://openalex.org/W1779463793', 'https://openalex.org/W1791888878', 'https://openalex.org/W1858533191', 'https://openalex.org/W1964385983', 'https://openalex.org/W1968068431', 'https://openalex.org/W1968378356', 'https://openalex.org/W1968837506', 'https://openalex.org/W1969134590', 'https://openalex.org/W1969442037', 'https://openalex.org/W1970548320', 'https://openalex.org/W1971113488', 'https://openalex.org/W1975024278', 'https://openalex.org/W1975584143', 'https://openalex.org/W1979380712', 'https://openalex.org/W1981085897', 'https://openalex.org/W1983128464', 'https://openalex.org/W1984418041', 'https://openalex.org/W1984562250', 'https://openalex.org/W1985898684', 'https://openalex.org/W1988224683', 'https://openalex.org/W1990332775', 'https://openalex.org/W1990841830', 'https://openalex.org/W1991394829', 'https://openalex.org/W1991545574', 'https://openalex.org/W1997611649', 'https://openalex.org/W1998470098', 'https://openalex.org/W1999954329', 'https://openalex.org/W2000246028', 'https://openalex.org/W2001557131', 'https://openalex.org/W2002054992', 'https://openalex.org/W2002243207', 'https://openalex.org/W2004247994', 'https://openalex.org/W2004496585', 'https://openalex.org/W2004767003', 'https://openalex.org/W2006579698', 'https://openalex.org/W2006728906', 'https://openalex.org/W2008543595', 'https://openalex.org/W2009007155', 'https://openalex.org/W2011073796', 'https://openalex.org/W2011360946', 'https://openalex.org/W2011860226', 'https://openalex.org/W2012271054', 'https://openalex.org/W2015417856', 'https://openalex.org/W2016391867', 'https://openalex.org/W2016538937', 'https://openalex.org/W2017739738', 'https://openalex.org/W2018075481', 'https://openalex.org/W2018786910', 'https://openalex.org/W2019046763', 'https://openalex.org/W2019558984', 'https://openalex.org/W2020094759', 'https://openalex.org/W2020486227', 'https://openalex.org/W2023823393', 'https://openalex.org/W2024306318', 'https://openalex.org/W2028125482', 'https://openalex.org/W2028525522', 'https://openalex.org/W2029065481', 'https://openalex.org/W2029818484', 'https://openalex.org/W2038009022', 'https://openalex.org/W2038641650', 'https://openalex.org/W2041414354', 'https://openalex.org/W2041896692', 'https://openalex.org/W2042512129', 'https://openalex.org/W2050133752', 'https://openalex.org/W2051341959', 'https://openalex.org/W2053073281', 'https://openalex.org/W2054538338', 'https://openalex.org/W2054946481', 'https://openalex.org/W2058078993', 'https://openalex.org/W2058628193', 'https://openalex.org/W2059411043', 'https://openalex.org/W2062517296', 'https://openalex.org/W2063592572', 'https://openalex.org/W2068427129', 'https://openalex.org/W2068715852', 'https://openalex.org/W2070732456', 'https://openalex.org/W2073067473', 'https://openalex.org/W2074433596', 'https://openalex.org/W2074483197', 'https://openalex.org/W2075395967', 'https://openalex.org/W2078230526', 'https://openalex.org/W2083592023', 'https://openalex.org/W2088281838', 'https://openalex.org/W2090551359', 'https://openalex.org/W2091545748', 'https://openalex.org/W2092214723', 'https://openalex.org/W2094079572', 'https://openalex.org/W2096286606', 'https://openalex.org/W2096806896', 'https://openalex.org/W2097767970', 'https://openalex.org/W2098851635', 'https://openalex.org/W2099110265', 'https://openalex.org/W2101859467', 'https://openalex.org/W2102436071', 'https://openalex.org/W2103002807', 'https://openalex.org/W2105092450', 'https://openalex.org/W2105196235', 'https://openalex.org/W2107867112', 'https://openalex.org/W2111752734', 'https://openalex.org/W2112842133', 'https://openalex.org/W2112911113', 'https://openalex.org/W2113280225', 'https://openalex.org/W2113925725', 'https://openalex.org/W2115476193', 'https://openalex.org/W2118783753', 'https://openalex.org/W2123543080', 'https://openalex.org/W2123619341', 'https://openalex.org/W2124432707', 'https://openalex.org/W2126404692', 'https://openalex.org/W2127339720', 'https://openalex.org/W2128404479', 'https://openalex.org/W2129171769', 'https://openalex.org/W2129172946', 'https://openalex.org/W2132670577', 'https://openalex.org/W2133492954', 'https://openalex.org/W2143291276', 'https://openalex.org/W2143637724', 'https://openalex.org/W2146157811', 'https://openalex.org/W2157533301', 'https://openalex.org/W2160115491', 'https://openalex.org/W2161221839', 'https://openalex.org/W2161437969', 'https://openalex.org/W2162756412', 'https://openalex.org/W2163762157', 'https://openalex.org/W2166249949', 'https://openalex.org/W2167368929', 'https://openalex.org/W2167997534', 'https://openalex.org/W2171830717', 'https://openalex.org/W2177206102', 'https://openalex.org/W2179910484', 'https://openalex.org/W2261566286', 'https://openalex.org/W22834613', 'https://openalex.org/W232361230', 'https://openalex.org/W2428502146', 'https://openalex.org/W2735212872', 'https://openalex.org/W2912148361', 'https://openalex.org/W3080988173', 'https://openalex.org/W4231876369', 'https://openalex.org/W4233109732', 'https://openalex.org/W4233304506', 'https://openalex.org/W4238607864', 'https://openalex.org/W4240881130', 'https://openalex.org/W4243147447', 'https://openalex.org/W4246988894', 'https://openalex.org/W4250251221', 'https://openalex.org/W4299914010'], 'related_works': ['https://openalex.org/W4361262569', 'https://openalex.org/W4361244094', 'https://openalex.org/W2118252141', 'https://openalex.org/W2072525392', 'https://openalex.org/W2060818930', 'https://openalex.org/W2046867705', 'https://openalex.org/W2033982645', 'https://openalex.org/W2000285806', 'https://openalex.org/W1988602328', 'https://openalex.org/W1858533191'], 'abstract_inverted_index': {'Protein': [0], 'kinase': [1, 11, 34, 151, 156], 'B/AKT': [2], 'plays': [3], 'a': [4, 25, 41], 'central': [5], 'role': [6], 'in': [7, 17, 196, 203, 218, 249], 'cancer.': [8], 'The': [9], 'serine/threonine': [10], 'is': [12], 'over-expressed': [13], 'or': [14, 116, 193], 'constitutively': [15], 'active': [16], 'many': [18], 'cancers': [19], 'and': [20, 64, 100, 123, 143, 198, 221, 230, 237, 244], 'has': [21, 36], 'been': [22, 128, 169, 191], 'validated': [23], 'as': [24, 121], 'therapeutic': [26], 'target': [27], 'for': [28], 'cancer': [29], 'treatment.': [30], 'However,': [31], 'targeting': [32, 71], 'the': [33, 47, 62, 72, 81, 94, 97, 103, 132, 135, 150, 155, 164, 182, 242, 250], 'activity': [35, 63, 157, 217], 'revealed': [37], 'itself': [38], 'to': [39, 44, 60, 96, 102, 138, 199, 241], 'be': [40], 'challenge': [42], 'due': [43], 'non-selectivity': [45], 'of': [46, 66, 70, 77, 83, 112, 134, 158, 185, 207, 223, 246], 'compounds': [48], 'towards': [49], 'other': [50, 55], 'kinases.': [51], 'This': [52], 'review': [53], 'summarizes': [54], 'approaches': [56, 189, 248], 'scientists': [57], 'have': [58, 127, 167, 190, 235], 'developed': [59], 'inhibit': [61, 131], 'function': [65], 'AKT.': [67, 78, 186], 'They': [68], 'consist': [69], 'pleckstrin': [73], 'homology': [74], '(PH)': [75], 'domain': [76, 137, 152, 184, 212], 'Indeed,': [79], 'upon': [80], 'generation': [82], '3-phosphorylated': [84], 'phosphatidylinositol': [85], 'phosphates': [86, 125], '(PI3Ps)': [87], 'by': [88, 161], 'PI3-kinase': [89], '(PI3K),': [90], 'AKT': [91, 210], 'translocates': [92], 'from': [93], 'cytosol': [95], 'plasma': [98], 'membrane': [99], 'binds': [101], 'PI3Ps': [104, 113], 'via': [105], 'its': [106], 'PH': [107, 136, 165, 183, 211], 'domain.': [108], 'Thus,': [109], 'several': [110, 172], 'analogs': [111], '(PI': [114], 'Analogs': [115], 'PIAs),': [117], 'alkylphospholipids': [118], '(APLs),': [119], 'such': [120, 247], 'edelfosine,': [122], 'inositol': [124], '(IPs)': [126], 'described': [129], 'that': [130, 146, 180], 'binding': [133], 'PI3Ps.': [139], 'Recently': [140], 'allosteric': [141], 'inhibitors': [142, 213], 'small': [144], 'molecules': [145], 'do': [147], 'not': [148], 'bind': [149, 181], 'but': [153], 'affect': [154], 'AKT,': [159], 'presumably': [160], 'interacting': [162], 'with': [163, 227], 'domain,': [166], 'also': [168], 'identified.': [170], 'Finally,': [171], 'drug': [173], 'screening': [174], 'studies': [175], 'spawned': [176], 'novel': [177], 'chemical': [178], 'scaffolds': [179], 'Together,': [187], 'these': [188, 208], 'more': [192], 'less': [194], 'successful': [195], 'vitro': [197], 'some': [200, 222], 'extent': [201], 'translated': [202], 'preclinical': [204], 'studies.': [205], 'Several': [206], 'new': [209], 'exhibit': [214], 'promising': [215], 'anti-tumor': [216], 'mouse': [219], 'models': [220], 'them': [224], 'show': [225], 'synergy': [226], 'ionizing': [228], 'radiation': [229], 'chemotherapy.': [231], 'Early': [232], 'clinical': [233], 'trials': [234], 'started': [236], 'results': [238], 'will': [239], 'attest': [240], 'validity': [243], 'efficacy': [245], 'near': [251], 'future.': [252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2033982645', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-09-13T09:44:15.811208', 'created_date': '2016-06-24'}