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3084, 3123, 3143, 3195, 3270, 3302, 3312, 3342, 3355, 3373, 3396, 3416, 3481, 3515, 3523, 3553, 3569, 3574, 3633, 3727, 3742, 3792, 3829, 3843, 4019, 4084, 4109, 4164, 4236, 4294, 4322, 4389, 4554, 4578, 4605, 4650, 4711, 4812, 4823, 4951, 4976, 5089, 5125, 5165, 5207, 5316, 5326, 5376], 'the': [7, 188, 206, 214, 250, 255, 264, 275, 382, 451, 492, 502, 554, 613, 680, 723, 748, 781, 785, 799, 826, 837, 849, 908, 932, 941, 961, 965, 976, 1005, 1104, 1114, 1121, 1144, 1152, 1179, 1192, 1277, 1293, 1296, 1305, 1343, 1359, 1466, 1504, 1509, 1511, 1517, 1558, 1585, 1616, 1662, 1733, 1740, 1752, 1773, 1784, 1833, 1899, 1912, 1921, 2048, 2051, 2063, 2147, 2154, 2162, 2177, 2324, 2357, 2464, 2525, 2546, 2614, 2664, 2696, 2793, 2818, 2891, 2900, 2913, 2920, 3019, 3042, 3047, 3055, 3161, 3221, 3225, 3232, 3245, 3263, 3271, 3317, 3331, 3343, 3347, 3382, 3410, 3469, 3512, 3516, 3518, 3531, 3539, 3543, 3570, 3604, 3614, 3658, 3661, 3769, 3782, 3787, 3793, 3800, 3808, 3817, 3822, 3834, 3888, 3900, 3916, 3964, 3974, 3993, 4016, 4079, 4184, 4240, 4367, 4423, 4476, 4682, 4715, 4852, 4878, 4921, 5055, 5090, 5093, 5252, 5327], 'Cardiovascular': [8, 256, 850, 5241], 'Health': [9, 257, 267, 851, 1147, 4083, 4479, 4748, 4765, 5259], 'Study': [10, 258, 268, 852, 1148, 4081], 'Neomi': [11, 36, 43], 'Shah,': [12, 37, 44], 'M.D.,': [13, 17, 23, 30, 38, 45, 119, 140], 'M.P.H.,': [14, 20, 31, 46], 'Tom': [15, 94], 'Rice,': [16, 95], 'Daniel': [18, 106], 'Tracy,': [19, 107], 'Thomas': [21, 117, 5272], 'Rohan,': [22, 118], 'Ph.D.,': [24, 27], 'Petra': [25, 129], 'Bůžková,': [26, 130], 'Anne': [28, 138], 'Newman,': [29, 139], 'Robert': [32, 151], 'C.': [33, 152], 'Kaplan,': [34, 153], 'Ph.D.': [35, 120, 131, 154], 'M.P.H.': [39, 108, 141], 'Address': [40], 'correspondence': [41], 'to:': [42], 'Albert': [47, 81, 109, 121, 155, 3975], 'Einstein': [48, 82, 110, 122, 156, 3976], 'College': [49, 83, 111, 123, 157, 3977], 'of': [50, 55, 84, 98, 101, 112, 124, 133, 143, 146, 158, 247, 254, 283, 299, 450, 589, 619, 625, 632, 784, 801, 829, 861, 885, 889, 934, 955, 964, 978, 1007, 1010, 1032, 1037, 1066, 1085, 1106, 1136, 1182, 1226, 1230, 1240, 1255, 1276, 1286, 1309, 1321, 1347, 1358, 1373, 1440, 1468, 1520, 1524, 1550, 1608, 1636, 1681, 1742, 1777, 1832, 1859, 1871, 1888, 1892, 1898, 1930, 1952, 2050, 2068, 2076, 2085, 2104, 2146, 2153, 2237, 2385, 2399, 2413, 2426, 2439, 2452, 2498, 2532, 2580, 2695, 2792, 2812, 2831, 2845, 2864, 2878, 2907, 2925, 2957, 2982, 3015, 3098, 3109, 3153, 3208, 3224, 3248, 3294, 3456, 3477, 3578, 3597, 3617, 3637, 3642, 3652, 3669, 3698, 3746, 3759, 3803, 3819, 3836, 3839, 3845, 3867, 3903, 3925, 3949, 3978, 3997, 4015, 4048, 4068, 4082, 4102, 4143, 4162, 4210, 4230, 4239, 4269, 4318, 4369, 4383, 4447, 4524, 4550, 4628, 4668, 4681, 4695, 4714, 4781, 4791, 4834, 4854, 4877, 4974, 5028, 5061, 5083, 5092, 5096, 5103, 5196, 5213, 5251, 5275, 5290, 5301, 5318, 5393], 'Medicine/Montefiore': [51], 'Medical': [52, 89], 'Center,': [53, 90], 'Department': [54], 'Medicine': [56, 3967, 5071, 5242], '-': [57], 'Pulmonary': [58, 65], 'Division,': [59], '111': [60], 'East': [61], '210th': [62], 'Street,': [63], 'Klau-3': [64], 'Sleep': [66, 265, 548, 560, 1145, 1499, 2247, 3966, 4477, 4746, 4763, 4980, 4984, 5053, 5070, 5155, 5209, 5255, 5258, 5277, 5302, 5394], 'Lab,': [67], 'Bronx,': [68, 86, 91, 114, 126, 160, 3980], 'NY': [69, 87, 92, 115, 127, 161], '10467(718)': [70], '920-2105(718)': [71], '652-8590': [72], 'E-mail': [73, 77], 'Address:': [74, 78], '[email': [75, 79], 'protected]': [76, 80], 'Medicine,': [85, 102, 113, 125, 147, 159, 3979, 5278, 5303], 'Montefiore': [88], ',': [93, 105, 116, 128, 137, 150, 5020, 5076, 5349], 'M.D.': [96], 'University': [97, 132, 142], 'Pittsburgh': [99, 144, 3952], 'School': [100, 145], 'Pittsburgh,': [103, 148], 'PA': [104, 149], 'Washington,': [134], 'Seattle,': [135], 'WA': [136], 'Published': [162], 'Online:December': [163], '15,': [164, 5362, 5387], '2013https://doi.org/10.5664/jcsm.3260Cited': [165], 'by:10SectionsAbstractPDF': [166], 'ShareShare': [167], 'onFacebookTwitterLinkedInRedditEmail': [168], 'ToolsAdd': [169], 'to': [170, 186, 212, 338, 367, 380, 499, 516, 676, 684, 746, 780, 797, 926, 952, 960, 974, 1035, 1178, 1250, 1377, 1417, 1541, 1547, 1563, 1640, 1647, 1672, 1703, 1716, 1853, 2024, 2070, 2524, 3018, 3168, 3261, 3304, 3314, 3592, 3620, 3675, 3704, 3798, 3815, 3831, 4169], 'favoritesDownload': [171], 'CitationsTrack': [172], 'Citations': [173], 'AboutABSTRACTStudy': [174], 'Objectives:Sleep': [175], 'sleep': [177, 181, 217, 331, 342, 347, 386, 420, 661, 666, 716, 718, 751, 755, 802, 805, 830, 833, 901, 903, 935, 979, 982, 1045, 1049, 1067, 1107, 1110, 1124, 1156, 1186, 1310, 1337, 1354, 1401, 1418, 1421, 1429, 1476, 1532, 1553, 1796, 1855, 2002, 2137, 2166, 2238, 2264, 2282, 2331, 2386, 2400, 2414, 2427, 2440, 2453, 2467, 2499, 2515, 2549, 2581, 2595, 2618, 2647, 2667, 2722, 2795, 2865, 2879, 2894, 2958, 2979, 3087, 3102, 3128, 3145, 3155, 3180, 3241, 3266, 3320, 3334, 3360, 3385, 3402, 3427, 3453, 3461, 3544, 3598, 3625, 3645, 3804, 3825, 4114, 4171, 4384, 4448, 4472, 4499, 4525, 4636, 4651, 4665, 4789, 4950, 5029, 5062, 5084, 5114, 5163], 'disordered': [178, 719, 806, 834, 904, 936, 983, 1050, 1111, 1187, 1311, 1422, 2239, 2500, 2582, 2723, 2796, 2897, 2959, 3181, 3335, 3361, 3386, 3403, 3805], 'breathing': [179, 720, 807, 835, 905, 937, 984, 1051, 1112, 1188, 2240, 2501, 2583, 2724, 2797, 2960, 3182, 3336, 3362, 3387, 3404, 3806, 4415, 4634], '(obstructive': [180], 'apnea': [182, 1157, 1469, 2980, 3428, 4115, 4172, 4500, 4526], '[OSA])': [183], 'are': [184, 196, 514, 696, 730, 913, 1031, 1798, 1812, 1827, 3393, 3508, 3526, 3813, 4945], 'known': [185, 675, 714, 899, 1869, 1893], 'affect': [187, 722, 883, 907, 3409], 'growth': [189, 191, 225, 229, 236, 551, 563, 565, 593, 639, 724, 726, 760, 763, 769, 786, 789, 811, 815, 838, 840, 865, 871, 877, 3989, 3999, 4040, 4071, 4103, 4132, 4185, 4188, 4215, 4260, 4291, 4313, 4341, 4551, 4669, 4684, 4687, 4898, 5122, 5396], 'hormone/insulin-like': [190, 564, 725, 839], 'factor': [192, 230, 237, 566, 727, 764, 770, 790, 841, 866, 872, 878, 910, 1058, 4041, 4072, 4133, 4261, 4292, 4314, 4342, 4365, 4504, 4688], '(GH/IGF)': [193], 'axis.': [194, 3163, 3323, 4190, 4720], 'There': [195, 3106], 'few': [197, 731, 914], 'relevant': [198, 732, 915], 'population': [199, 531, 733, 916, 1135, 1944, 2906], 'studies': [200, 734, 847, 917, 922, 1533, 1554, 3656, 3812], 'this': [202, 210, 590, 736, 744, 919, 949, 999, 1076, 1099, 2753, 2758, 2808, 2843, 3170, 3435, 3524, 3938], 'area,': [203], 'particularly': [204], 'elderly.': [207, 493, 3272], 'We': [208, 410, 432, 742, 1150, 1526, 1849, 2188, 3061, 3297, 3672, 3748], 'conducted': [209, 743, 1263, 3299, 3497], 'study': [211, 512, 745, 823, 1211, 1303, 1314, 1340, 1376, 1587, 1943, 2056, 2148, 2155, 2889, 2927, 3014, 3037, 3226, 3250, 3257, 3274, 3379, 3420, 3458, 3495, 3525, 3608, 3616, 3688, 3719, 3778], 'investigate': [213, 747], 'relationship': [215, 383, 482, 749, 930, 950, 1000, 1122, 1153, 1913, 2819, 2892, 2995, 3043, 3264, 3318, 3755, 3783, 3823], 'between': [216, 384, 417, 438, 483, 750, 931, 1123, 1154, 1914, 2164, 2235, 2466, 2496, 2510, 2548, 2578, 2592, 2616, 2645, 2666, 2719, 2820, 2853, 2893, 2935, 2955, 2977, 2996, 3026, 3044, 3067, 3141, 3179, 3206, 3265, 3319, 3333, 3384, 3425, 3493, 3624, 3733, 3756, 3784, 3824, 4203, 4897, 4920, 5113], '(architecture': [218, 752, 2895], 'OSA)': [220], 'circulating': [222, 389, 633, 758, 809, 859, 986, 1168, 1365, 1872, 2938, 2962, 3070, 3630, 3736, 3762, 3837, 3995, 4339, 4596, 4813], 'IGF-I': [223, 300, 626, 634, 694, 862, 987, 1011, 1069, 1366, 1612, 1643, 1963, 2255, 2289, 2350, 2597, 2823, 2856, 3010, 3071, 3092, 3104, 3133, 3216, 3506, 3520, 3840, 4597, 5158], '(insulin-like': [224, 228, 235], 'factor-1),': [226], 'IGFBP-1': [227, 314, 2304, 2352, 2390, 2404, 2418, 2431, 2444, 2457, 2651, 2869, 2883], 'binding': [231, 238, 765, 771, 867, 873, 879, 1018, 4139], 'protein-1),': [232], 'IGFBP-3': [234, 316, 393, 429, 447, 477, 1130, 1172, 1368, 1650, 1863, 1876, 1981, 2172, 2200, 2245, 2275, 2306, 2321, 2336, 2367, 2392, 2406, 2420, 2433, 2446, 2459, 2473, 2506, 2517, 2555, 2588, 2620, 2673, 2689, 2729, 2738, 2805, 2825, 2871, 2885, 2942, 2964, 2966, 2985, 3032, 3073, 3147, 3187, 3338, 3367, 3392, 3430, 3740, 3766, 5322], 'protein-3)': [239], 'levels': [240, 317, 430, 478, 695, 703, 773, 818, 860, 990, 1009, 1131, 1173, 1369, 1964, 1982, 2290, 2322, 2337, 2474, 2518, 2556, 2598, 2674, 2690, 2739, 2806, 2826, 2857, 2943, 3074, 3490, 3507, 3521, 3577, 3632, 3741, 3767, 3838, 3996, 4209, 4944], 'an': [242, 775, 844, 928, 1133, 1227, 1237, 1374, 1435, 1600, 1623, 1684, 2904, 2972, 3095, 3189, 3397, 3422, 3622, 3723, 3856], 'elderly': [243, 272, 522, 533, 740, 776, 820, 845, 992, 1134, 1175, 2905, 3016, 3056, 3398, 3571, 3638, 3744, 3770], 'population.Design': [244], 'Setting:Cross-sectional': [245], 'analysis': [246, 1923, 2811], 'participants': [248, 273, 1138, 1289, 1317, 1329, 1379, 1405, 1934, 3234], 'from': [249, 274, 1220, 1323, 1531, 3887, 3899, 3915, 3963, 4078, 4422, 4475], 'year': [251, 1278, 3476], '9': [252, 1279], 'visit': [253, 1281], '(CHS)': [259, 853], 'who': [260, 1139, 1351, 1407, 2026, 2909, 2916], 'were': [261, 318, 1140, 1248, 1262, 1290, 1388, 1555, 1582, 1591, 1613, 1659, 1670, 1701, 1721, 1818, 1837, 1866, 1965, 1983, 2231, 2493, 2575, 2715, 2799, 2910, 3465, 3648, 3673], 'enrolled': [262, 1213, 1291, 2911], 'Heart': [266, 1146, 4478, 4747, 4764], '(SHHS).Patients': [269], 'or': [270, 663, 1437, 1683, 1688, 1725, 1802, 1807, 1842, 2199, 2212, 2274, 2305, 2320, 2351, 2366, 2379, 2505, 2587, 2721, 2728, 2804, 2941, 2965, 3031, 3186, 3346, 3451, 3739], 'Participants:1,233': [271], 'CHS': [276, 1137, 1206, 1280, 1288, 1586, 1663, 1753, 2914, 3659, 3927, 3947], 'SHHS.Measurements': [278], 'Results:The': [280], 'mean': [281, 297, 1801, 1950, 1980, 2034, 3222, 3246], 'age': [282, 1322, 1951, 3223, 3247], 'males': [284, 303, 323, 339, 365, 2025, 2043, 2091, 2603, 2625, 2777, 3699], '(n': [285, 290, 1945, 2080, 2834], '=': [286, 291, 1946, 2081, 2292, 2295, 2299, 2339, 2345, 2536, 2542, 2605, 2611, 2627, 2630, 2634, 2653, 2656, 2741, 2744, 2748, 2765, 2768, 2772, 2779, 2782, 2786, 2835, 3502], '526)': [287], 'females': [289, 309, 321, 336, 368, 2011, 2015, 2037, 2096, 2116, 2522, 2763, 3116, 3701], '697)': [292], 'was': [293, 304, 332, 361, 378, 1432, 1446, 1463, 1501, 1514, 1638, 1714, 1730, 1749, 1765, 1924, 2007, 2038, 2092, 2097, 2110, 2249, 2267, 2285, 2312, 2332, 2519, 2599, 2621, 2734, 2933, 2953, 2975, 3107, 3228, 3339, 3351, 3363, 3370, 3446, 3854, 3871, 3911, 3940, 3971], '77': [294], 'years.': [295, 3254], 'The': [296, 481, 1260, 1313, 1461, 1763, 2033, 2083, 2102, 2508, 2590, 2922, 3640, 3860, 4972, 5239], 'value': [298, 2075], '(ng/mL)': [301, 2691], '112.4': [305], 'vs.': [306, 344, 370, 1973, 1989, 2040, 2130], '97.1': [307, 1974], '(p': [310, 324, 2030, 2044, 2099, 2117], '<': [311, 325, 350, 373, 471, 1977, 1993, 2031, 2045, 2100, 2118, 2133, 2660], '0.01).': [312, 326, 351, 374, 2032, 2046, 2101, 2119], 'Mean': [313, 1962], 'higher': [319, 1966, 1984], 'than': [322, 704, 1497, 1969, 2004, 2012, 2127], 'As': [327, 1274], 'expected,': [328, 354], 'slow': [329, 418, 659, 2210, 2377], 'wave': [330, 419, 660, 4664, 5398], 'better': [333, 1910, 2001, 2008, 3259, 3315, 3832], 'preserved': [334, 2009], 'compared': [337, 366, 2023, 2523], '(22%': [340], 'total': [341, 346, 1285, 1475, 1518], 'time': [343, 1477, 2511, 3083, 3142, 4449, 4856], '9%': [345], 'time,': [348], 'p': [349, 372, 1976, 1992, 2132, 2298, 2344, 2541, 2610, 2633, 2659, 2747, 2771, 2785], 'Furthermore,': [352, 494], 'as': [353, 505, 1055, 1356, 1362, 1364, 1371, 1396, 1434, 1448, 1465, 1516, 1535, 1656, 1732, 1800, 1809, 1847, 1857, 1937, 2191, 3052, 3057, 3442, 3542, 3650, 4362, 4501], 'OSA': [355, 439, 466, 495, 1915, 2086, 2106, 2733, 2821, 2854, 3209, 3628, 3760], '(apneahypopnea': [356], 'index': [357, 943, 1506, 1513, 1529, 2126], '[AHI]': [358], '≥': [359, 441, 468, 1318, 1442, 1454, 1695, 1940, 2088, 2108, 2839], '5/h)': [360, 442], 'more': [362, 697], 'prevalent': [363], '(60%': [369], '46%,': [371], 'Multivariable': [375, 2383, 2397, 2411, 2424, 2437, 2450, 2862, 2876], 'linear': [376, 436, 1851], 'regression': [377, 1852, 1922, 3555], 'used': [379, 1850, 3522], 'determine': [381], 'objective': [385, 1353, 1400], 'parameters': [387, 2167], 'IGF-I,': [390, 426, 444, 620, 946, 1127, 1169, 1860, 1873, 1917, 2169, 2197, 2242, 2272, 2318, 2364, 2389, 2403, 2417, 2430, 2443, 2456, 2470, 2503, 2552, 2585, 2670, 2686, 2726, 2802, 2868, 2882, 2939, 2963, 3029, 3184, 3389, 3737, 3763, 5321], 'IGFBP-1,': [391, 427, 445, 1128, 1170, 1609, 1824, 1861, 1874, 1918, 2170, 2198, 2243, 2273, 2319, 2365, 2471, 2504, 2553, 2586, 2671, 2687, 2727, 2803, 2940, 3030, 3185, 3390, 3738, 3764], 'levels,': [394, 3093, 3148], 'with': [395, 476, 621, 654, 700, 705, 1024, 1493, 2014, 2066, 2073, 2254, 2271, 2288, 2303, 2317, 2335, 2349, 2388, 2402, 2416, 2429, 2442, 2455, 2529, 2737, 2801, 2837, 2867, 2881, 3008, 3090, 3112, 3131, 3240, 3366, 3440, 3449, 3530, 3695, 3896, 4045, 4074, 4112, 4450, 4601, 4816, 4820, 4947, 4978, 5320], 'adjustment': [396, 2216, 2479, 2561, 2700, 2987], 'for': [397, 994, 1059, 1253, 1342, 1543, 1642, 1649, 1868, 2078, 2201, 2217, 2368, 2393, 2407, 2421, 2434, 2447, 2460, 2480, 2562, 2692, 2701, 2872, 2886, 2946, 2988, 3157, 3283, 3549, 3644, 3677, 4366, 4505, 4735, 4742, 4788, 4851, 5372, 5382], 'age,': [398, 793, 970, 2218, 2481, 2563, 2702, 3288, 4629, 4696], 'sex,': [399, 1879, 4630], 'race,': [400, 1880, 2220, 2482, 2564, 2704], 'BMI,': [401, 1881, 2221, 2483, 2565, 2705, 3289], 'diabetes,': [402, 2222, 2484, 2566, 2706], 'estrogen': [403, 2223, 2485, 2567, 2707], 'use,': [404, 406, 2224, 2226, 2486, 2488, 2568, 2570, 2708, 2710], 'progestin': [405, 2225, 2487, 2569, 2709], 'physical': [408, 1789, 1884, 2228, 2490, 2572, 2712, 3290, 3682, 4857, 5324], 'activity.': [409], 'did': [411, 454, 3165, 3173, 3720, 3750], 'not': [412, 455, 489, 497, 1722, 2059, 2251, 2268, 2302, 2314, 2348, 2600, 2622, 2775, 2789, 2859, 3051, 3118, 3166, 3174, 3340, 3371, 3394, 3407, 3447, 3466, 3586, 3721, 3751, 3855, 3987], 'detect': [413, 3175, 3593, 3722], 'a': [414, 571, 644, 651, 1056, 1082, 1201, 1208, 1284, 1299, 1331, 1409, 1755, 1788, 1927, 1938, 1949, 2074, 2123, 2641, 2828, 2993, 3138, 3150, 3176, 3203, 3352, 3443, 3634, 3667, 3753, 4052, 4363, 4420, 4502, 4531, 4743, 5296], 'significant': [415, 435, 490, 2233, 2601, 2623, 2642, 2717, 2851, 2931, 2951, 3024, 3065, 3139, 3177, 3341, 3353, 3395, 3730, 3754], 'association': [416, 437, 2163, 2465, 2509, 2547, 2591, 2615, 2644, 2665, 2759, 2852, 2932, 2952, 2974, 3140, 3178, 3190, 3332, 3354, 3424, 3445, 3623, 3732], '(SWS)': [421, 662], '(per': [422], '5': [423, 469, 2662, 2682, 2861, 2875], 'min)': [424, 2206, 2373], '(ng/mL).': [431], 'found': [433, 2849, 2934, 3022, 3062, 3080, 3328, 3485, 3933], 'no': [434, 2232, 2494, 2576, 2716, 2850, 3023, 3864], '(AHI': [440, 467, 2087, 2107, 2981], 'levels.': [448, 1864, 2173, 2246, 2258, 2276, 2307, 2353, 2507, 2589, 2730, 2967, 3033, 3105, 3134, 3368, 3602], 'Gender-stratification': [449], 'entire': [452, 2178, 2526, 3344], 'cohort': [453, 1210, 1229, 1239, 1302, 1999, 2755, 3345, 3399, 3745], 'alter': [456], 'these': [457, 1029, 1905], 'findings.': [458, 3689], 'Sensitivity': [459], 'analyses': [460, 1199, 1345, 1906, 2360, 3301, 3483, 3710], 'excluding': [461, 3307], 'diabetics': [462], 'revealed': [463], 'that': [464, 575, 647, 693, 715, 900, 948, 1212, 1334, 3041, 3081, 3122, 3191, 3219, 3329, 3381, 3401, 3460, 3533, 3572, 3583, 3663, 3781], 'moderate': [465, 2105, 2732, 2978, 3359, 3426], '15)': [472, 2109], 'is': [473, 488, 576, 596, 612, 635, 674, 713, 795, 898, 972, 1100, 1117, 1207, 1298, 2058, 2640, 2683, 3050, 3088, 3129, 3252, 3258, 3275, 3459, 3562, 3581, 3613, 3790, 4043, 4599], 'inversely': [474, 2286, 2735, 3364], 'associated': [475, 699, 1161, 2253, 2270, 2287, 2316, 2334, 2736, 2800, 3007, 3089, 3130, 3365, 4044, 4600, 4946], 'women.Conclusions': [480], 'SWS': [484, 2006, 2022, 2311, 2720, 2936, 2997, 3003, 3027, 3045, 3734, 3785], 'GH/IGF': [486, 503, 909, 1193, 3162, 3268, 3322, 3788, 3809, 3827], 'system': [487, 569, 574, 2902, 3789, 3828, 4787], 'does': [496, 3406], 'appear': [498, 3167], 'adversely': [500, 3408], 'influence': [501, 1084, 1105, 3097, 3152, 3802], 'axis,': [504, 728], 'reported': [506, 1679, 1799, 3202], 'younger': [508, 3059, 3417, 3728, 3774], 'individuals.': [509, 741, 2677, 2814, 3060], 'Whether': [510, 1098], 'our': [511, 1197, 1998, 2055, 2926, 3013, 3036, 3249, 3256, 3280, 3378, 3457, 3554, 3607, 3687, 3691, 3718, 3743, 3777], 'findings': [513, 2924, 3779, 4474, 4604], 'due': [515], 'diminished': [517, 1086], 'GH/IGF-I': [518, 1087, 1115, 2901, 3048], 'axis': [519, 791, 842, 968, 1088, 1116, 3049, 3269, 3413, 4018, 4315, 4577, 4923], 'activity': [520, 1748, 3683, 4713, 5325], 'needs': [523], 'further': [524, 3276, 3685], 'investigation': [525], 'by': [526, 638, 940, 1103, 1474, 1557, 1739, 1767, 1814, 1907, 2756, 3278, 3559, 3873, 3913, 3942, 4971], 'replication': [527], 'other': [529, 855, 1579, 2794, 3605, 4818], 'large': [530, 3654], 'based': [532], 'cohorts.Citation:Shah': [534], 'N;': [535], 'Rice': [536], 'T;': [537, 541], 'Tracy': [538], 'D;': [539], 'Rohan': [540], 'Bůžková': [542], 'P;': [543], 'Newman': [544, 4444, 4625], 'A;': [545], 'Kaplan': [546], 'RC.': [547], 'insulin-like': [550, 592, 608, 759, 762, 768, 788, 810, 814, 864, 870, 876, 3998, 4039, 4070, 4214, 4290, 4340], 'factors': [552], 'cardiovascular': [555, 891, 1307, 3847], 'health': [556], 'study.': [557, 3859, 4055, 4533, 4745], 'J': [558, 4001, 4088, 4117, 4146, 4243, 4347, 4510, 4535, 4722, 4859, 4885, 4955, 5011, 5014, 5270], 'Clin': [559, 4002, 4118, 4147, 4348, 4434], 'Med': [561, 4830, 4960], '2013;9(12):1245-1251.INTRODUCTIONThe': [562], '(GH/': [567], 'IGF)': [568], 'comprises': [570], 'complex': [572], 'endocrine': [573], 'involved': [577, 1142], 'embryonic': [579], 'development,': [580], 'growth,': [581], 'normal': [583, 4390], 'adult': [584], 'physiology.': [585], 'A': [586, 3922, 4827, 4957], 'key': [587, 1580, 4548], 'mediator': [588], 'system,': [591, 1901], 'factor-1': [594, 812, 5123], '(IGF-I),': [595], 'important': [597, 686, 796, 973, 3284, 3678, 3707], 'modulating': [599], 'cell': [600], 'proliferation,': [601], 'differentiation,': [602], 'survival/apoptosis,': [604], 'also': [606, 1021, 1141, 1903, 2121, 2250, 2313, 2917, 3005, 3172, 3298, 3749], 'has': [607, 643, 3004, 3192, 3201, 3609, 3958], 'metabolic': [609, 1062], 'effects.': [610], 'GH': [611, 628, 642, 656, 673, 689, 702, 3000, 4922], 'main': [614], 'signal': [615], 'controlling': [616], 'liver': [617], 'production': [618], 'reciprocal': [622], 'inhibitory': [623], 'effects': [624, 1065, 3596, 4627], 'on': [627, 792, 808, 836, 969, 985, 1068, 1089, 1113, 1184, 1191, 1271, 1403, 1723, 2019, 3035, 3103, 3160, 3468, 3538, 3600, 3807, 3821, 3919, 4386, 4410, 4428, 4635], 'secretion.': [629, 3001], 'Physiologic': [630], 'regulation': [631, 1897, 4680], 'controlled': [636], 'mainly': [637], 'hormone': [640, 3990, 4104, 4685, 4899], '(GH).': [641], 'pulsatile': [645, 678, 681, 706], 'secretion': [646, 682, 3991, 4105], 'varies': [648], 'markedly': [649], 'diurnal': [652], 'fashion,': [653], 'most': [655], 'produced': [657], 'during': [658, 1234, 1245, 1584, 5162], 'stage': [664, 2208, 2262, 2280, 2375, 2593, 3085, 3100, 3126], 'N3': [665], '(formerly': [667], 'stages': [668, 4790], '3': [669, 2182, 2410, 2423, 2462], '4).': [671], 'While': [672, 711], 'be': [677, 685, 927, 953, 3438, 3932, 4167], 'seems': [683], 'some': [688, 1013], 'effects,': [690], 'it': [691, 712, 794, 897, 971, 3580], 'appears': [692, 951, 3797], 'strongly': [698, 3528], 'basal': [701], 'GH.1BRIEF': [707], 'SUMMARYCurrent': [708], 'Knowledge/Study': [709], 'Rationale:': [710], 'may': [721, 906, 1001, 1073, 3585, 4166], 'there': [729, 912, 925, 2230, 2492, 2574, 2639, 2714, 3350], 'area': [737], 'specifically': [738], 'involving': [739], 'obstructive': [754, 1155, 4113, 4170], 'apnea)': [756], 'factor-1,': [761], 'protein-1,': [766], 'protein-3': [772, 880, 4140, 4263], 'population.Study': [777], 'Impact:': [778], 'Due': [779, 959, 1177], 'substantial': [782, 962], 'dependence': [783, 963], 'hormone/': [787], 'understand': [798, 825, 975, 3833], 'impact': [800, 828, 977, 1181, 4694], 'architecture': [803, 831, 980, 1108, 1125, 1419, 2248, 3626], 'factor-binding': [816], 'protein': [817], 'among': [819, 991, 1174, 1967, 1985, 2139, 2475, 2521, 2557, 3058, 3115, 3231, 3238, 3431, 3488, 3711, 3768, 3773], 'patients.': [821, 4297], 'This': [822, 3120, 3369, 3869], 'helps': [824], 'independent': [827, 954], 'population.Prior': [846], 'cohorts': [856], 'have': [857, 923, 1020, 1052, 1673, 1704, 3535, 3587, 3862], 'implicated': [858, 1054], 'proteins': [868, 1019], '(e.g.,': [869], 'protein-1': [874], '[IGFBP-1],': [875], '[IGFBP-3],': [881], 'which': [882, 1413, 3684], 'bioactivity': [884, 4598], 'IGF-I),': [886], 'risk': [888, 1036, 1057, 3844, 4047, 4142, 4317, 4364, 4503], 'cancer,': [890, 3846], 'diseases,': [892, 3848], 'functional': [893, 3849, 4821], 'status,': [894, 3850], 'mortality.2–4While': [896], 'axis,5–7': [911], 'area.': [920], 'Prior': [921], 'shown': [924], 'inverse': [929, 2643, 2973, 3423], 'severity': [933], '(as': [938, 3414, 3725, 3771], 'measured': [939, 1370, 1660, 1734, 1743, 1750, 3519], 'apnea-hypopnea': [942], '[AHI])': [944], 'BMI': [956, 1729, 1939, 2838], 'age.5–7': [958], 'GH/': [966, 3411], 'IGF': [967, 1017, 1821, 1900, 3412, 3463, 3601, 3631, 4017, 4138, 4300, 4904, 4928], 'IGFBP': [989, 2257], 'patients': [993, 2833, 2908, 4111], 'several': [995, 3706], 'reasons.': [996], 'First,': [997], 'understanding': [998], 'help': [1002], 'determining': [1004], 'cause': [1006], 'altered': [1008], 'older': [1014, 1042, 1349, 4824, 4953, 5128], 'adults.8': [1015], 'Second,': [1016], 'been': [1022, 1053, 3006, 3193, 3536], 'linked': [1023], 'circadian': [1025, 4204], 'regulatory': [1026], 'mechanisms9,10': [1027], 'IGF-BPs': [1030], 'proven': [1033], 'relevance': [1034], 'diabetes': [1038, 1060, 1095, 1674, 1882, 3713, 4321, 4451], 'death': [1040], 'adults.11–13,14': [1043], 'Third,': [1044], 'quality,': [1046], 'duration,': [1047], 'disorder,': [1063], 'related': [1071, 1096, 1546, 4168], 'mediators': [1072], 'possibly': [1074], 'explain': [1075], 'association.15–21': [1077], 'Fourth,': [1078], 'emerging': [1079], 'evidence': [1080, 3108], 'suggests': [1081, 3121, 3421], 'positive': [1083, 3151, 3731, 5293], 'longevity': [1090], '(via': [1091], 'improved': [1092], 'cancer': [1093], 'outcomes).22–24': [1097], 'partially': [1101], 'mediated': [1102], 'unknown.We': [1118], 'therefore': [1119], 'investigated': [1120, 2817], '(SHHS).': [1149], 'examined': [1151, 1925], '(OSA)': [1158], 'its': [1160, 3618], 'characteristics,': [1162], 'namely': [1163], 'hypoxemia': [1164], 'arousal,': [1166], 'participants.': [1176, 1273, 2477, 2559, 3376, 3639, 3747], 'major': [1180, 2923], 'gender': [1183, 1202, 1894, 2809, 3110], 'SWS,25': [1185], 'prevalence,26': [1189], 'axis,27–29': [1194], 'we': [1195, 1902, 2061, 2751, 2816, 2848, 3021, 3039, 3079, 3136, 3327, 3484, 3547, 3584], 'present': [1196, 1344], 'primary': [1198, 4295], 'stratified': [1203, 1813, 1904, 2752, 2810], 'manner.METHODSStudy': [1204], 'PopulationThe': [1205], 'longitudinal': [1209], '5,888': [1214], 'adults,': [1215], '65': [1216], 'years': [1217, 1320, 1954, 3230, 3237], 'older,': [1219], '4': [1221, 2160, 2184, 2436, 2449, 2544], 'US': [1222], 'communities.': [1223], 'It': [1224, 3612], 'consists': [1225], 'original': [1228], '5,201': [1231], 'individuals': [1232, 1243, 3311, 3492], 'recruited': [1233, 1244], '1989-1990': [1235], 'additional': [1238, 3482, 3897], 'African': [1241], 'American': [1242, 3965, 5391], '1992-1993.': [1246], 'Participants': [1247, 1700], 'invited': [1249], 'repeated': [1251], 'examinations': [1252, 1261], 'collection': [1254], 'data': [1256, 1402, 1530, 3709, 4741], 'blood': [1258, 1594], 'specimens.': [1259], 'annually': [1264], 'through': [1265], '1999,': [1266], 'again': [1268], '2005-2006': [1270], 'surviving': [1272], 'part': [1275, 1357, 1372, 3651], 'cycle': [1282], '(1998),': [1283], '1,350': [1287], 'into': [1292], 'SHHS.': [1294, 2921], 'Briefly,': [1295], 'SHHS': [1297, 1328, 1360, 1395, 1559, 3662, 3943], 'multicenter': [1300, 4744], 'prospective': [1301], 'evaluating': [1304], 'natural': [1306], 'consequences': [1308], 'breathing.30,31': [1312], 'includes': [1315], '6,441': [1316, 1404], '40': [1319], 'multiple': [1324, 3567], 'population-based': [1325, 3635, 4053, 4080, 4532], 'cohorts.': [1326], 'All': [1327, 1552], 'underwent': [1330, 1408], 'baseline': [1332, 1676], 'examination': [1333], 'included': [1335, 1482, 1956], 'portable': [1336], 'monitoring.': [1338], 'Our': [1339, 3273, 3419], 'sample': [1341, 1929, 2057, 2830, 2844, 3227, 3251, 3636, 3693], 'consisted': [1346], '1,233': [1348], 'adults': [1350], 'had': [1352, 1691, 1948, 2000, 2122, 3588], 'measurement': [1355, 3643], 'evaluation,': [1361], 'well': [1363], 'ancillary': [1375], 'CHS.All': [1378], 'provided': [1380, 1414, 3912], 'informed': [1381], 'consent,': [1382], 'institutional': [1384], 'review': [1385], 'board': [1386], 'approvals': [1387], 'obtained': [1389, 3537], 'at': [1390, 1605, 1615, 1661, 1675, 3934, 3973], 'all': [1391, 2394, 2408], 'participating': [1392], 'institutions.Sleep': [1393], 'MeasurementsThe': [1394], 'described': [1397, 3194], 'above': [1398, 1834, 2358], 'collected': [1399, 1583, 1595, 3467], '(1995-1998)': [1406], 'full-montage': [1410], 'unattended': [1411, 4739], 'polysomnogram,': [1412], 'measurements': [1415, 1590, 1654, 3532], 'pertaining': [1416], 'breathing.': [1423], 'Additionally,': [1424], 'they': [1425, 1678, 1690, 1720], 'completed': [1426], 'questionnaires': [1427], 'about': [1428, 1772], 'habits.': [1430], 'Apnea': [1431, 4981, 5210], 'defined': [1433, 1447, 1515, 1936], 'absence': [1436, 1439], 'near': [1438], 'airflow': [1441, 1452], '10': [1443, 1459], 'seconds.': [1444, 1460], 'Hypopnea': [1445], '70%': [1449], 'decrease': [1450], 'plus': [1453], '4%': [1455, 1639], 'desaturation': [1456], 'lasting': [1457], '>': [1458], 'AHI': [1462, 2035, 2052, 2065, 2079], 'calculated': [1464, 1731], 'number': [1467, 1519], 'hypopnea': [1471], 'events': [1472], 'divided': [1473, 1738], 'hours.': [1479], 'Hypoxemia': [1480], 'variables': [1481, 1817, 1836, 1856, 2798, 2948, 3286, 3552, 3561, 3599, 3680], 'average': [1483, 2020, 3213], 'oxygen': [1484, 1487, 1494], 'saturation,': [1485, 1488], 'lowest': [1486], 'T90': [1490], '(time': [1491], 'spent': [1492, 2027, 2260, 2278, 2309, 2328, 2512], 'saturation': [1495], 'less': [1496, 2136], '90%).': [1498], 'fragmentation': [1500, 2138, 4385], 'assessed': [1502], 'using': [1503, 1593, 1596, 1626, 1666, 1754, 1839], 'arousal': [1505, 1512, 1528, 2125], 'variable.': [1507, 2698], 'In': [1508, 2842, 3012, 3218, 3243, 3324, 3564, 3936], 'SHHS,': [1510, 3950], 'arousals': [1521], 'per': [1522], 'hour': [1523], 'sleep.': [1525, 2214, 4701, 4901, 4925], 'excluded': [1527], 'coded': [1534], '"sleep': [1536], 'wake': [1537], 'only"': [1538], 'order': [1540, 3313, 3830], 'account': [1542], 'technical': [1544], 'issues': [1545], 'EEG': [1548], 'scoring': [1549, 4786], 'arousals.': [1551], 'scored': [1556], 'reading': [1560], 'center': [1561], 'according': [1562], 'Rechtschaffen': [1564, 4776], 'Kales': [1566, 4778], 'criteria.32IGF': [1567], 'Other': [1569, 1652], 'MeasurementsPhysical': [1570], 'cognitive': [1572], 'function': [1573], 'tests,': [1574], 'questionnaires,': [1575], 'laboratory': [1576, 1653], 'panels,': [1577], 'covariates': [1581], 'examinations.': [1588], 'Laboratory': [1589, 1665], 'performed': [1592, 1614, 3972], 'standard': [1597, 1667, 1805], 'procedures': [1598], 'after': [1599, 1622, 2944, 2986], 'overnight': [1601], 'fast': [1602], 'stored': [1604], '-70°C.': [1606], 'Measurements': [1607], 'IGFBP-3,': [1610, 1920], 'Jewish': [1617], 'General': [1618], 'Hospital': [1619], '(Montreal,': [1620], 'Canada)': [1621], 'extraction': [1624], 'step': [1625], 'ELISA': [1627], 'methods': [1628, 3641], '(Diagnostics': [1629], 'Systems': [1630], 'Laboratory,': [1631], 'Webster,': [1632], 'TX).': [1633], 'Assay': [1634], 'coefficient': [1635], 'variation': [1637], '6%': [1641], 'concentration,': [1644], '3%': [1646], '5%': [1648], 'concentration.33': [1651], 'such': [1655], 'fasting': [1657, 1692, 1706, 1710], 'glucose': [1658, 1694, 1707, 1712, 4387, 4455], 'Central': [1664], 'methods.Clinical': [1668], 'VariablesParticipants': [1669], 'considered': [1671, 1702], 'if': [1677, 1689, 1708], 'use': [1680, 1887, 3293], 'insulin': [1682, 1724, 5116, 5120], 'oral': [1685, 1726], 'hypoglycemic': [1686, 1727], 'agent': [1687], 'serum': [1693, 1711, 4038, 4069, 4208, 4289], '7.0': [1696], 'mmol/L': [1697], '(126': [1698], 'mg/dL).': [1699], 'impaired': [1705, 4454], 'their': [1709, 3670], 'level': [1713, 2531, 4161], '110': [1715], '125': [1717], 'mg/dL': [1718], 'agents.': [1728], 'weight': [1735], 'kilograms': [1737], 'square': [1741], 'height': [1744], 'meters.': [1746], 'Physical': [1747, 4882], 'validated': [1756], 'questionnaire-the': [1757], 'Modified': [1758], 'Minnesota': [1759, 4879], 'Leisure-Time': [1760], 'Activities': [1761], 'Questionnaire.34,35': [1762], 'questionnaire': [1764, 4850], 'administered': [1766], 'trained': [1768], 'interviewers,': [1769], 'inquired': [1771], 'frequency': [1774], 'duration': [1776, 4361], 'participation': [1778], '15': [1780], 'leisure-time': [1781], 'activities': [1782], '2': [1785, 2175, 2281, 2382, 2396, 2594, 3086, 3101, 3127, 4320, 4371, 4418, 4507], 'weeks': [1786], 'preceding': [1787], 'examination.AnalysisDescriptive': [1790], 'statistics': [1791], 'including': [1792, 1878, 3287, 3681], 'demographic,': [1793], 'clinical,': [1794], 'characteristics': [1797, 2145, 2152], 'median': [1803], '(±': [1804], 'deviation': [1806], 'range,': [1808], 'appropriate)': [1810], 'gender.': [1815], 'Skewed': [1816], 'log': [1819], 'transformed.': [1820], 'concentrations': [1822, 5159], '(IGF-I,': [1823], 'IGFBP-3)': [1826], 'similarly': [1828], 'described.': [1829], 'Gender-based': [1830], 'comparisons': [1831], 'noted': [1835], 'made': [1838], 'χ2,': [1840], 't-test,': [1841], 'Wilcoxon': [1843], 'rank': [1844], 'sum': [1845], 'analyses,': [1846, 3306], 'appropriate.': [1848], 'model': [1854], 'predictive': [1858], 'Models': [1865], 'adjusted': [1867, 3548], 'determinants': [1870], 'concentrations,': [1877], 'mellitus,': [1883], 'activity,': [1885, 2229, 2491, 2573, 2713, 3291], 'sex': [1889, 3295, 4211], 'hormones.': [1890, 3296], 'Because': [1891], 'dimorphism': [1895], 'sex.': 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'evaluated': [2890], 'breathing)': [2898], 'participated': [2918], 'are:': [2928], '(a)': [2929], 'No': [2930, 2950], 'adjusting': [2945, 3279], 'confounding': [2947, 2989, 3285, 3551, 3558, 3679], '(b)': [2949], 'detected': [2954, 2976], '(c)': [2968], 'Among': [2969], '15-30/h)': [2983], 'variables.Numerous': [2990], 'studies27,36,37': [2991], 'support': [2992, 3910], 'strong': [2994, 3486], 'increased': [2999, 3009, 3082, 3099, 3125, 4046, 4948], 'Increased': [3002], 'levels.38': [3011], 'individuals,': [3017], 'contrary,': [3020], 'correlation': [3025, 3205, 3487], 'Based': [3034], 'findings,': [3038], 'conclude': [3040], 'robust': [3053, 3692], 'weak': [3063], 'yet': [3064], 'non-SWS': [3068], '(Tables': [3075], '2–5).': [3076], 'For': [3077], 'instance,': [3078], 'reduced': [3091, 3132], 'adverse': [3096, 3801], 'differences,': [3111], 'males.': [3119], 'saw': [3137], '(surrogate': [3156], 'consolidated': [3158], 'sleep)': [3159], 'Gender': [3164], 'modify': [3169], 'relationship.We': [3171], 'levels;': [3188], 'prior': [3196], 'studies.5–7': [3197], 'Ursavas': [3198, 4154], 'et': [3199], 'al.': [3200], 'negative': [3204], '(arousal': [3210], 'index,': [3211], 'AHI,': [3212], 'desaturation)': [3214], 'levels.7': [3217], 'study,': [3220], '48.8': [3229], 'control': [3233], '52': [3236], 'apnea.': [3242], 'comparison,': [3244], 'Therefore,': [3255, 3377], 'designed': [3260], 'strengthened': [3277], 'multivariable': [3281], 'models': [3282], 'sensitivity': [3305, 4108], 'diabetic': [3310, 5127], 'doing': [3325], 'so,': [3326], 'although': [3330], 'cohort;': [3349], 'non-diabetics,': [3357], 'where': [3358], 'seen': [3372, 3415, 3448, 3726], 'demonstrates': [3380], 'likely': [3405, 3527], 'individuals).': [3418, 3775], 'non-diabetics.': [3433], 'finding': [3436], 'should': [3437], 'interpreted': [3439], 'caution,': [3441], 'mild': [3450], 'severe': [3452], 'apnea.A': [3454], 'limitation': [3455], 'same': [3470, 3540], 'day': [3471, 3541], 'rather': 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'roughly': [3666], 'third': [3668], 'sample.': [3671], 'able': [3674], 'adjust': [3676], 'strengthens': [3686], 'size': [3694], 'numbers': [3697], 'allowed': [3702], 'us': [3703], 'conduct': [3705], 'secondary': [3708], 'obesity-restricted': [3715], 'samples.In': [3716], 'summary,': [3717], 'expected': [3724, 3772], 'individuals)': [3729], 'observe': [3752], 'indices': [3758], 'Collectively,': [3776], 'suggest': [3780], 'weaker': [3791], 'aging': [3796, 3820, 4555], 'dilute': [3799], 'system.': [3810], 'Future': [3811], 'needed': [3814], 'clarify': [3816], 'role': [3818, 4549], 'implications': [3835], 'IGFBPs': [3842], 'mortality.DISCLOSURE': [3852], 'STATEMENTThis': [3853], 'industry': [3857], 'supported': [3858, 3872, 3941], 'authors': [3861], 'indicated': [3863], 'financial': [3865], 'conflicts': [3866], 'interest.': [3868], 'research': [3870, 3960], 'contracts': [3874], 'HHSN268201200036C,': [3875], 'HHSN268200800007C,': [3876], 'N01HC55222,': [3877], 'N01HC85079,': [3878], 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'pulsatile,': [3988], 'determines': [3992], 'ambient': [3994], 'factor-I.': [4000, 4216], 'Endocrinol': [4003, 4119, 4148, 4349], 'Metab;': [4004, 4120, 4149, 4350], '2010;95:2486-91,': [4005], '20190159.': [4006], 'CrossrefGoogle': [4007, 4059, 4092, 4123, 4152, 4177, 4194, 4223, 4251, 4278, 4304, 4327, 4353, 4377, 4395, 4438, 4462, 4485, 4514, 4542, 4564, 4587, 4613, 4643, 4659, 4706, 4726, 4754, 4864, 4890, 4909, 4933, 4964], 'Scholar2': [4008], 'Biernacka': [4009], 'KM,': [4010], 'Perks': [4011], 'CM,': [4012], 'Holly': [4013], 'JMRole': [4014], 'prostate': [4020], 'cancer.': [4021, 4557], 'Minerva': [4022], 'Endocrinol;': [4023, 4089, 4584, 4723], '2012;37:173-85,': [4024], '22691890.': [4025], 'Google': [4026, 4674, 4774, 4802, 4836], 'Scholar3': [4027], 'Juul': [4028], 'A,': [4029, 4155, 4777, 4990, 5031, 5037, 5137, 5338], 'Scheike': [4030], 'T,': [4031, 5003, 5262], 'Davidsen': [4032], 'M,': [4033, 4157, 4180, 4309, 5001, 5005, 5009, 5064, 5134, 5169, 5225, 5332, 5334], 'Gyllenborg': [4034], 'J,': [4035, 4490, 4845, 5041, 5141, 5264], 'Jorgensen': [4036], 'TLow': [4037], 'I': [4042, 4073, 4293, 4343, 4690, 5098], 'ischemic': [4049, 4144], 'heart': [4050], 'disease:': [4051], 'case-control': [4054], 'Circulation;': [4056], '2002;106:939-44,': [4057], '12186797.': [4058], 'Scholar4': [4060], 'Empen': [4061], 'K,': [4062, 4496, 5219], 'Lorbeer': [4063], 'R,': [4064, 5330], 'Volzke': [4065], 'Het': [4066], 'al.Association': [4067, 4446], 'endothelial': [4075], 'function:': [4076], 'Results': [4077], 'Pomerania': [4085], '(SHIP).': [4086], 'Eur': [4087, 4721], '2010;163:617-23,': [4090], '20651065.': [4091], 'Scholar5': [4093], 'Gianotti': [4094], 'L,': [4095, 5035, 5266, 5268], 'Pivetti': [4096], 'S,': [4097, 4467, 4616, 4729, 5130], 'Lanfranco': [4098], 'Fet': [4099], 'al.Concomitant': [4100], 'impairment': [4101], 'peripheral': [4107], 'syndrome.': [4116, 4173], '2002;87:5052-7,': [4121], '12414871.': [4122], 'Scholar6': [4124], 'Johnsen': [4125], 'SP,': [4126], 'Hundborg': [4127], 'HH,': [4128], 'Sorensen': [4129], 'HTet': [4130], 'al.Insulin-like': [4131, 4259, 4312], '(IGF)': [4134], 'I,': [4135, 4995], '-II,': [4136], 'stroke.': [4145], '2005;90:5937-41,': [4150], '16131586.': [4151], 'Scholar7': [4153], 'Karadag': [4156], 'Ilcol': [4158], 'YOet': [4159], 'al.Low': [4160, 4595], 'obesity': [4165], 'Lung;': [4174], '2007;185:309-14,': [4175], '17721831.': [4176], 'Scholar8': [4178], 'Sherlock': [4179], 'Toogood': [4181], 'AAAging': [4182], 'hormone/insulin': [4186], 'like': [4187, 5121], 'factor-I': [4189], 'Pituitary;': [4191], '2007;10:189-203,': [4192], '17492509.': [4193], 'Scholar9': [4195], 'Chu': [4196], 'LW,': [4197], 'Zhu': [4198], 'Y,': [4199, 5033], 'Yu': [4200], 'Ket': [4201], 'al.Correlation': [4202], 'gene': [4205], 'variants': [4206], 'steroids': [4212], 'Cancer': [4217], 'Epidemiol': [4218], 'Biomarkers': [4219], 'Prev;': [4220], '2008;17:3268-73,': [4221], '18990770.': [4222], 'Scholar10': [4224], 'Amaral': [4225], 'IP,': [4226], 'Johnston': [4227], 'IACircadian': [4228], 'expression': [4229], 'clock': [4231], 'putative': [4233], 'clock-controlled': [4234], 'genes': [4235], 'skeletal': [4237], 'muscle': [4238], 'zebrafish.': [4241], 'Am': [4242, 4509, 4534], 'Physiol': [4244], 'Regul': [4245], 'Integr': [4246], 'Comp': [4247], 'Physiol;': [4248], '2012;302:R193-206,': [4249], '22031781.': [4250], 'Scholar11': [4252], 'Chen': [4253], 'W,': [4254], 'Salojin': [4255], 'KV,': [4256], 'Mi': [4257], 'QSet': [4258], '(IGF)-I/IGF-binding': [4262], 'complex:': [4264], 'therapeutic': [4265], 'efficacy': [4266], 'mechanism': [4268], 'protection': [4270], 'against': [4271], 'type': [4272, 4319, 4370, 4417, 4506, 4528, 4689], 'diabetes.': [4274, 4372, 4508], 'Endocrinology;': [4275], '2004;145:627-38,': [4276], '14617576.': [4277], 'Scholar12': [4279], 'Friedrich': [4280], 'N,': [4281, 4488, 5223], 'Schneider': [4282], 'H,': [4283, 5039], 'Dorr': [4284], 'Met': [4285], 'al.All-cause': [4286], 'mortality': [4287], 'care': [4296], 'Horm': [4299, 4903, 4927], 'Res;': [4301, 4905, 4929], '2011;21:102-6,': [4302], '21435927.': [4303], 'Scholar13': [4305], 'Rajpathak': [4306], 'SN,': [4307], 'He': [4308], 'Sun': [4310], 'Qet': [4311], 'women.': [4323], 'Diabetes;': [4324], '2012;61:2248-54,': [4325], '22554827.': [4326], 'Scholar14': [4328], 'Burgers': [4329], 'AM,': [4330], 'Biermasz': [4331], 'NR,': [4332], 'Schoones': [4333], 'JWet': [4334], 'al.Meta-analysis': [4335], 'dose-response': [4337], 'metaregression:': [4338], '(IGF-I)': [4344, 4691], 'mortality.': [4346], '2011;96:2912-20,': [4351], '21795450.': [4352], 'Scholar15': [4354], 'Yaggi': [4355, 4497], 'HK,': [4356], 'Araujo': [4357], 'AB,': [4358], 'McKinlay': [4359], 'JBSleep': [4360], 'development': [4368], 'Diabetes': [4373, 4407, 4425, 4432, 4481], 'Care;': [4374, 4482], '2006;29:657-61,': [4375], '16505522.': [4376], 'Scholar16': [4378], 'Stamatakis': [4379], 'KA,': [4380], 'Punjabi': [4381, 4399, 4442], 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