Title: Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: The Chingford Study
Abstract: Arthritis & RheumatismVolume 42, Issue 1 p. 17-24 Research ArticleFree to Read Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: The Chingford Study Deborah J. Hart, Corresponding Author Deborah J. Hart St. Thomas' Hospital, London, UKTwin Research and Osteoporosis Unit, St. Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UKSearch for more papers by this authorDavid V. Doyle, David V. Doyle Whipps Cross Hospital, London, UKSearch for more papers by this authorTim D. Spector, Tim D. Spector St. Thomas' Hospital, London, UKSearch for more papers by this author Deborah J. Hart, Corresponding Author Deborah J. Hart St. Thomas' Hospital, London, UKTwin Research and Osteoporosis Unit, St. Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UKSearch for more papers by this authorDavid V. Doyle, David V. Doyle Whipps Cross Hospital, London, UKSearch for more papers by this authorTim D. Spector, Tim D. Spector St. Thomas' Hospital, London, UKSearch for more papers by this author First published: 22 May 2001 https://doi.org/10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-ECitations: 250AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objective To examine the natural history, role of risk factors, and incidence of knee osteoarthritis (OA) in a prospective study of women from a population cohort. Methods Women from the Chingford Study who had been recruited in 1989 were followed up with knee radiographs 4 years later. A total of 715 paired radiographs (71% of the original sample) were graded for osteophytes and 644 for joint space narrowing (JSN). Women whose radiographs had been graded as 0 in 1989 and as ≥14 years later were classified as having incident disease. Incident cases were compared with controls for associations with a number of risk factors. Results Eighty-one women (12.6%) developed JSN of the knee, equating to an incidence of 3.1% per year. No clear risk factors for JSN were identified. Reproducibility of measures of joint space is poor, however, leading to inaccuracy of definition. Incident knee osteophytes developed in 95 women (13.3%), equating to an incidence of 3.3% per year. Compared with controls, women with incident knee osteophytes were older, heavier, and had more hand OA and knee symptoms. Women in the top tertile of obesity (body mass index >26.4) had a significantly increased risk of incident knee osteophytes (odds ratio [OR] 2.38, 95% confidence interval [95% CI] 1.29–4.39). Incident knee osteophytes increased by 20% per 5-year age increase. A nonsignificant protective effect for incident knee osteophytes was seen with current estrogen replacement therapy (ERT) (OR 0.41, 95% CI 0.12–1.42). No effect was associated with smoking, physical activity, hysterectomy, or previous knee injury. Conclusion Obesity and aging are associated with a high risk of new knee OA developing in women. Evidence of a protective effect of ERT was seen. No clear association was found for incident JSN, suggesting that different etiologic mechanisms are operating or that standard radiographs are an inaccurate measure of incident narrowing. Citing Literature Volume42, Issue1January 1999Pages 17-24 RelatedInformation
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 389
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot