Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2033103357', 'doi': 'https://doi.org/10.1110/ps.062505607', 'title': 'Probing the folding intermediate of Rd‐apocyt <i>b<sub>562</sub></i> by protein engineering and infrared <i>T</i>‐jump', 'display_name': 'Probing the folding intermediate of Rd‐apocyt <i>b<sub>562</sub></i> by protein engineering and infrared <i>T</i>‐jump', 'publication_year': 2007, 'publication_date': '2007-05-02', 'ids': {'openalex': 'https://openalex.org/W2033103357', 'doi': 'https://doi.org/10.1110/ps.062505607', 'mag': '2033103357', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17473017', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2206668'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1110/ps.062505607', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S156919612', 'display_name': 'Protein Science', 'issn_l': '0961-8368', 'issn': ['0961-8368', '1469-896X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2206668?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100428001', 'display_name': 'Ting Wang', 'orcid': 'https://orcid.org/0000-0003-2257-0699'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ting Wang', 'raw_affiliation_strings': ['Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA', 'These authors contributed equally.'], 'affiliations': [{'raw_affiliation_string': 'These authors contributed equally.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053210714', 'display_name': 'Zheng Zhou', 'orcid': 'https://orcid.org/0000-0002-1423-7231'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zheng Zhou', 'raw_affiliation_strings': ['Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA', 'These authors contributed equally.'], 'affiliations': [{'raw_affiliation_string': 'These authors contributed equally.', 'institution_ids': []}, {'raw_affiliation_string': 'Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053653239', 'display_name': 'Michelle R. Bunagan', 'orcid': 'https://orcid.org/0000-0003-3782-9915'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michelle R. Bunagan', 'raw_affiliation_strings': ['Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA', 'These authors contributed equally.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}, {'raw_affiliation_string': 'These authors contributed equally.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068256721', 'display_name': 'Deguo Du', 'orcid': 'https://orcid.org/0000-0002-8701-8208'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Deguo Du', 'raw_affiliation_strings': ['Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069137667', 'display_name': 'Yawen Bai', 'orcid': 'https://orcid.org/0000-0003-3239-1109'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yawen Bai', 'raw_affiliation_strings': ['Feng Gai, Department of Chemistry, University of Pennsylvania, 231 S. 34th St., Philadelphia, PA 19104, USA', 'Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA', 'Yawen Bai, Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Building 37, Room 6114E, Bethesda, MD 20892, USA', 'fax: (215) 573-2112', 'fax: (301) 402-3095.'], 'affiliations': [{'raw_affiliation_string': 'Feng Gai, Department of Chemistry, University of Pennsylvania, 231 S. 34th St., Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}, {'raw_affiliation_string': 'Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238']}, {'raw_affiliation_string': 'Yawen Bai, Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Building 37, Room 6114E, Bethesda, MD 20892, USA', 'institution_ids': ['https://openalex.org/I4210140884']}, {'raw_affiliation_string': 'fax: (301) 402-3095.', 'institution_ids': []}, {'raw_affiliation_string': 'fax: (215) 573-2112', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5015329154', 'display_name': 'Feng Gai', 'orcid': 'https://orcid.org/0000-0003-1621-7119'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Feng Gai', 'raw_affiliation_strings': ['Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA', 'Feng Gai, Department of Chemistry, University of Pennsylvania, 231 S. 34th St., Philadelphia, PA 19104, USA', 'Yawen Bai, Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Building 37, Room 6114E, Bethesda, MD 20892, USA', 'fax: (215) 573-2112', 'fax: (301) 402-3095.'], 'affiliations': [{'raw_affiliation_string': 'Feng Gai, Department of Chemistry, University of Pennsylvania, 231 S. 34th St., Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}, {'raw_affiliation_string': 'Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}, {'raw_affiliation_string': 'Yawen Bai, Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Building 37, Room 6114E, Bethesda, MD 20892, USA', 'institution_ids': ['https://openalex.org/I4210140884']}, {'raw_affiliation_string': 'fax: (301) 402-3095.', 'institution_ids': []}, {'raw_affiliation_string': 'fax: (215) 573-2112', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5069137667', 'https://openalex.org/A5015329154'], 'corresponding_institution_ids': ['https://openalex.org/I79576946', 'https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I79576946', 'https://openalex.org/I4210140884'], 'apc_list': {'value': 4070, 'currency': 'USD', 'value_usd': 4070, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.516, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.576471, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '16', 'issue': '6', 'first_page': '1176', 'last_page': '1183'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11162', 'display_name': 'Macromolecular Crystallography Techniques', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11162', 'display_name': 'Macromolecular Crystallography Techniques', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure Prediction and Analysis', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin Function and Regulation in Vertebrates', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/intermediate-state', 'display_name': 'Intermediate state', 'score': 0.68504375}, {'id': 'https://openalex.org/keywords/temperature-jump', 'display_name': 'Temperature jump', 'score': 0.5768223}, {'id': 'https://openalex.org/keywords/folding', 'display_name': 'Folding (DSP implementation)', 'score': 0.5390071}, {'id': 'https://openalex.org/keywords/contact-order', 'display_name': 'Contact order', 'score': 0.5075358}, {'id': 'https://openalex.org/keywords/equilibrium-unfolding', 'display_name': 'Equilibrium unfolding', 'score': 0.5034031}, {'id': 'https://openalex.org/keywords/proteins', 'display_name': 'Proteins', 'score': 0.449506}], 'concepts': [{'id': 'https://openalex.org/C162203774', 'wikidata': 'https://www.wikidata.org/wiki/Q7181581', 'display_name': 'Phi value analysis', 'level': 3, 'score': 0.71330404}, {'id': 'https://openalex.org/C2780702060', 'wikidata': 'https://www.wikidata.org/wiki/Q86901', 'display_name': 'Intermediate state', 'level': 2, 'score': 0.68504375}, {'id': 'https://openalex.org/C204328495', 'wikidata': 'https://www.wikidata.org/wiki/Q847556', 'display_name': 'Protein folding', 'level': 2, 'score': 0.6626658}, {'id': 'https://openalex.org/C19472624', 'wikidata': 'https://www.wikidata.org/wiki/Q583851', 'display_name': 'Native state', 'level': 2, 'score': 0.6229285}, {'id': 'https://openalex.org/C8010536', 'wikidata': 'https://www.wikidata.org/wiki/Q160398', 'display_name': 'Crystallography', 'level': 1, 'score': 0.60435104}, {'id': 'https://openalex.org/C65550862', 'wikidata': 'https://www.wikidata.org/wiki/Q2142563', 'display_name': 'Temperature jump', 'level': 2, 'score': 0.5768223}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5548325}, {'id': 'https://openalex.org/C2776545253', 'wikidata': 'https://www.wikidata.org/wiki/Q5464292', 'display_name': 'Folding (DSP implementation)', 'level': 2, 'score': 0.5390071}, {'id': 'https://openalex.org/C206276672', 'wikidata': 'https://www.wikidata.org/wiki/Q5164839', 'display_name': 'Contact order', 'level': 3, 'score': 0.5075358}, {'id': 'https://openalex.org/C175188612', 'wikidata': 'https://www.wikidata.org/wiki/Q5384491', 'display_name': 'Equilibrium unfolding', 'level': 3, 'score': 0.5034031}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.4802994}, {'id': 'https://openalex.org/C46449900', 'wikidata': 'https://www.wikidata.org/wiki/Q5303170', 'display_name': 'Downhill folding', 'level': 4, 'score': 0.4607137}, {'id': 'https://openalex.org/C133571119', 'wikidata': 'https://www.wikidata.org/wiki/Q899102', 'display_name': 'Circular dichroism', 'level': 2, 'score': 0.37819266}, {'id': 'https://openalex.org/C159467904', 'wikidata': 'https://www.wikidata.org/wiki/Q2001702', 'display_name': 'Chemical physics', 'level': 1, 'score': 0.35066628}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.2132453}, {'id': 'https://openalex.org/C147789679', 'wikidata': 'https://www.wikidata.org/wiki/Q11372', 'display_name': 'Physical chemistry', 'level': 1, 'score': 0.16725346}, {'id': 'https://openalex.org/C184779094', 'wikidata': 'https://www.wikidata.org/wiki/Q26383', 'display_name': 'Atomic physics', 'level': 1, 'score': 0.10516593}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10202438}, {'id': 'https://openalex.org/C149923435', 'wikidata': 'https://www.wikidata.org/wiki/Q37732', 'display_name': 'Demography', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C144024400', 'wikidata': 'https://www.wikidata.org/wiki/Q21201', 'display_name': 'Sociology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C119599485', 'wikidata': 'https://www.wikidata.org/wiki/Q43035', 'display_name': 'Electrical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003573', 'descriptor_name': 'Cytochrome b Group', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D015202', 'descriptor_name': 'Protein Engineering', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D002942', 'descriptor_name': 'Circular Dichroism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003573', 'descriptor_name': 'Cytochrome b Group', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003573', 'descriptor_name': 'Cytochrome b Group', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015202', 'descriptor_name': 'Protein Engineering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013696', 'descriptor_name': 'Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1110/ps.062505607', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S156919612', 'display_name': 'Protein Science', 'issn_l': '0961-8368', 'issn': ['0961-8368', '1469-896X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2206668', 'pdf_url': 'https://europepmc.org/articles/pmc2206668?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206668', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17473017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2206668', 'pdf_url': 'https://europepmc.org/articles/pmc2206668?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.59, 'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1588812136', 'https://openalex.org/W1964610252', 'https://openalex.org/W1968291593', 'https://openalex.org/W1977652400', 'https://openalex.org/W1993045239', 'https://openalex.org/W1998447012', 'https://openalex.org/W2002967710', 'https://openalex.org/W2007577495', 'https://openalex.org/W2011655736', 'https://openalex.org/W2020275234', 'https://openalex.org/W2024379184', 'https://openalex.org/W2025336895', 'https://openalex.org/W2028909116', 'https://openalex.org/W2037349497', 'https://openalex.org/W2040362675', 'https://openalex.org/W2048065572', 'https://openalex.org/W2060528711', 'https://openalex.org/W2062759724', 'https://openalex.org/W2063392510', 'https://openalex.org/W2073585058', 'https://openalex.org/W2073859576', 'https://openalex.org/W2079606633', 'https://openalex.org/W2082176608', 'https://openalex.org/W2084642783', 'https://openalex.org/W2089597488', 'https://openalex.org/W2092103509', 'https://openalex.org/W2092356013', 'https://openalex.org/W2094655254', 'https://openalex.org/W2096599403', 'https://openalex.org/W2112444949', 'https://openalex.org/W2115511579', 'https://openalex.org/W2123132657', 'https://openalex.org/W2135674818', 'https://openalex.org/W2171755502', 'https://openalex.org/W2479736984'], 'related_works': ['https://openalex.org/W819534777', 'https://openalex.org/W4256114139', 'https://openalex.org/W2585259690', 'https://openalex.org/W2089597488', 'https://openalex.org/W2085479332', 'https://openalex.org/W2074816766', 'https://openalex.org/W2040362675', 'https://openalex.org/W2037244907', 'https://openalex.org/W2021903435', 'https://openalex.org/W2018060167'], 'abstract_inverted_index': {'Abstract': [0], 'Small': [1], 'proteins': [2], 'often': [3], 'fold': [4], 'in': [5, 114, 158, 172], 'an': [6, 95], 'apparent': [7, 153], 'two‐state': [8, 154], 'manner': [9], 'with': [10, 174], 'the': [11, 26, 41, 102, 107, 115, 127, 140, 144, 159, 175, 184, 197, 202], 'absence': [12], 'of': [13, 118, 130, 187, 201], 'detectable': [14], 'early‐folding': [15], 'intermediates.': [16], 'Recently,': [17], 'using': [18], 'native‐state': [19], 'hydrogen': [20], 'exchange,': [21], 'intermediates': [22, 47], 'that': [23, 89, 177, 196], 'exist': [24], 'after': [25], 'rate‐limiting': [27], 'transition': [28], 'state': [29, 133, 204, 208], 'have': [30, 55, 72], 'been': [31, 87], 'identified': [32], 'for': [33], 'several': [34], 'proteins.': [35], 'However,': [36, 157], 'little': [37], 'is': [38, 181, 209], 'known': [39], 'about': [40], 'folding': [42, 155, 179, 185], 'kinetics': [43], 'from': [44, 205], 'these': [45, 169], 'post‐transition': [46], 'to': [48, 67, 75, 124], 'their': [49], 'corresponding': [50], 'native': [51, 141, 203], 'states.': [52], 'Herein,': [53], 'we': [54], 'used': [56], 'protein': [57], 'engineering': [58], 'and': [59, 71], 'a': [60, 80, 110, 178], 'laser‐induced': [61], 'temperature‐jump': [62], '(': [63], 'T': [64, 160], '‐jump)': [65], 'technique': [66], 'investigate': [68], 'this': [69, 131, 150, 206], 'issue': [70], 'applied': [73], 'it': [74, 85, 193], 'Rd‐apocyt': [76, 90, 119, 188], 'b': [77, 91, 120, 189], '562': [78, 92, 121, 190], ',': [79], 'four‐helix': [81], 'bundle': [82], 'protein.': [83], 'Previously,': [84], 'has': [86, 100], 'shown': [88], 'folds': [93], 'via': [94], 'on‐pathway': [96], 'hidden': [97], 'intermediate,': [98], 'which': [99], 'only': [101], 'N‐terminal': [103, 116], 'helix': [104, 117], 'unfolded.': [105], 'In': [106, 143], 'present': [108], 'study,': [109], 'double': [111], 'mutation': [112], '(V16G/I17A)': [113], 'was': [122, 194], 'made': [123], 'further': [125], 'increase': [126], 'relative': [128], 'population': [129], 'intermediate': [132, 180, 207], 'at': [134, 214], 'high': [135], 'temperature': [136], 'by': [137], 'selectively': [138], 'destabilizing': [139], 'state.': [142], 'circular': [145], 'dichroism': [146], 'thermal': [147], 'melting': [148], 'experiment,': [149, 162], 'mutant': [151], 'showed': [152], 'behavior.': [156], '‐jump': [161], 'two': [163], 'kinetic': [164], 'phases': [165], 'were': [166], 'observed.': [167], 'Therefore,': [168], 'results': [170], 'are': [171], 'agreement': [173], 'idea': [176], 'populated': [182], 'on': [183], 'pathway': [186], '.': [191], 'Moreover,': [192], 'found': [195], 'exponential': [198], 'growth': [199], 'rate': [200], 'roughly': [210], '(25': [211], 'μsec)': [212], '−1': [213], '65°C.': [215]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2033103357', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-24T21:29:41.220319', 'created_date': '2016-06-24'}