Title: Hyaluronate turnover during chondrogenesis in the developing chick limb and axial skeleton
Abstract: Hyaluronidase activity is first detected in leg and wing buds and the axial trunk region of chick embryos at the onset of cartilage differentiation and continues during subsequent chondrogenesis. Incorporation of isotopic precursors into hyaluronate is demonstrated in early stages of development of both limb bud and axial skeleton. The ratios of incorporation of acetate-3H into hyaluronate and chondroitin sulfate in both regions is higher prior to the appearance of cartilage than subsequently and is greater at all the stages of axial chondrogenesis studied than at corresponding stages in the limb bud. A hypothesis is further discussed in which hyaluronate production accompanies mesenchymal cell movements and its removal is necessary for differentiation of these cells.
Publication Year: 1972
Publication Date: 1972-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 240
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