Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2032571621', 'doi': 'https://doi.org/10.1021/jm00378a010', 'title': '[[(Aminomethyl)aryl]oxy]acetic acid esters. A new class of high-ceiling diuretics. 1. Effects of nitrogen and aromatic nuclear substitution', 'display_name': '[[(Aminomethyl)aryl]oxy]acetic acid esters. A new class of high-ceiling diuretics. 1. Effects of nitrogen and aromatic nuclear substitution', 'publication_year': 1984, 'publication_date': '1984-12-01', 'ids': {'openalex': 'https://openalex.org/W2032571621', 'doi': 'https://doi.org/10.1021/jm00378a010', 'mag': '2032571621', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6502591'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm00378a010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049473796', 'display_name': 'Cheuk Man Lee', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Cheuk Man Lee', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111933018', 'display_name': 'Jacob J. Plattner', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jacob J. Plattner', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023886619', 'display_name': 'C. Wayne Ours', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C. Wayne Ours', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002800937', 'display_name': 'Bruce W. Horrom', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bruce W. Horrom', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075570014', 'display_name': 'Jill R. Smital', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jill R. Smital', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019204603', 'display_name': 'Yvonne C. Martin', 'orcid': 'https://orcid.org/0000-0002-2077-7816'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yvonne C. Martin', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037742294', 'display_name': 'André G. Pernet', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Andre G. Pernet', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069276628', 'display_name': 'Paul R. Bunnell', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Paul R. Bunnell', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015914815', 'display_name': 'Souheir E. El Masry', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Souheir E. El Masry', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080657823', 'display_name': 'Patrick W. Dodge', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Patrick W. Dodge', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.642, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 20, 'citation_normalized_percentile': {'value': 0.842021, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '27', 'issue': '12', 'first_page': '1579', 'last_page': '1587'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12191', 'display_name': 'Chemical Reaction Mechanisms', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12191', 'display_name': 'Chemical Reaction Mechanisms', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T13115', 'display_name': 'Axial and Atropisomeric Chirality Synthesis', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T13304', 'display_name': 'Synthesis and Reactivity of Sulfur-Containing Compounds', 'score': 0.9873, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/electrophilic-aromatic-substitution', 'display_name': 'Electrophilic aromatic substitution', 'score': 0.46591687}, {'id': 'https://openalex.org/keywords/substitution', 'display_name': 'Substitution (logic)', 'score': 0.4479779}, {'id': 'https://openalex.org/keywords/ceiling', 'display_name': 'Ceiling (cloud)', 'score': 0.43986365}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.9615166}, {'id': 'https://openalex.org/C2781076698', 'wikidata': 'https://www.wikidata.org/wiki/Q718074', 'display_name': 'Aryl', 'level': 3, 'score': 0.7234222}, {'id': 'https://openalex.org/C2776673659', 'wikidata': 'https://www.wikidata.org/wiki/Q47512', 'display_name': 'Acetic acid', 'level': 2, 'score': 0.58442986}, {'id': 'https://openalex.org/C537208039', 'wikidata': 'https://www.wikidata.org/wiki/Q627', 'display_name': 'Nitrogen', 'level': 2, 'score': 0.5369167}, {'id': 'https://openalex.org/C122085161', 'wikidata': 'https://www.wikidata.org/wiki/Q597833', 'display_name': 'Electrophilic aromatic substitution', 'level': 2, 'score': 0.46591687}, {'id': 'https://openalex.org/C155647269', 'wikidata': 'https://www.wikidata.org/wiki/Q243455', 'display_name': 'Medicinal chemistry', 'level': 1, 'score': 0.4491628}, {'id': 'https://openalex.org/C2778220771', 'wikidata': 'https://www.wikidata.org/wiki/Q1522579', 'display_name': 'Substitution (logic)', 'level': 2, 'score': 0.4479779}, {'id': 'https://openalex.org/C2777489069', 'wikidata': 'https://www.wikidata.org/wiki/Q1589822', 'display_name': 'Ceiling (cloud)', 'level': 2, 'score': 0.43986365}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.4185001}, {'id': 'https://openalex.org/C2780263894', 'wikidata': 'https://www.wikidata.org/wiki/Q335268', 'display_name': 'Alkyl', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C153294291', 'wikidata': 'https://www.wikidata.org/wiki/Q25261', 'display_name': 'Meteorology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004232', 'descriptor_name': 'Diuretics', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D006016', 'descriptor_name': 'Glycolates', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001681', 'descriptor_name': 'Biological Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004232', 'descriptor_name': 'Diuretics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005665', 'descriptor_name': 'Furosemide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005665', 'descriptor_name': 'Furosemide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005919', 'descriptor_name': 'Glomerular Filtration Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005919', 'descriptor_name': 'Glomerular Filtration Rate', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006016', 'descriptor_name': 'Glycolates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006016', 'descriptor_name': 'Glycolates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006016', 'descriptor_name': 'Glycolates', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D007202', 'descriptor_name': 'Indicators and Reagents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008252', 'descriptor_name': 'Macaca fascicularis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008744', 'descriptor_name': 'Methylamines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008744', 'descriptor_name': 'Methylamines', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D008744', 'descriptor_name': 'Methylamines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D008744', 'descriptor_name': 'Methylamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011918', 'descriptor_name': 'Rats, Inbred SHR', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': 'Q000652', 'qualifier_name': 'urine', 'is_major_topic': False}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm00378a010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6502591', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.45, 'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3158338669', 'https://openalex.org/W2767250287', 'https://openalex.org/W2581715027', 'https://openalex.org/W2575869988', 'https://openalex.org/W2393147081', 'https://openalex.org/W2379444625', 'https://openalex.org/W2354178882', 'https://openalex.org/W2153490381', 'https://openalex.org/W2081139303', 'https://openalex.org/W2077682573'], 'abstract_inverted_index': {'ADVERTISEMENT': [0], 'RETURN': [1], 'TO': [2], 'ISSUEPREVArticleNEXT[[(Aminomethyl)aryl]oxy]acetic': [3], 'acid': [4], 'esters.': [5], 'A': [6], 'new': [7], 'class': [8], 'of': [9, 14, 84, 119, 145], 'high-ceiling': [10], 'diuretics.': [11], '1.': [12], 'Effects': [13], 'nitrogen': [15], 'and': [16, 47, 94, 99, 128, 172, 189, 205, 207], 'aromatic': [17], 'nuclear': [18], 'substitutionCheuk': [19], 'Man': [20], 'Lee,': [21], 'Jacob': [22], 'J.': [23, 52], 'Plattner,': [24], 'C.': [25, 35], 'Wayne': [26], 'Ours,': [27], 'Bruce': [28], 'W.': [29, 49], 'Horrom,': [30], 'Jill': [31], 'R.': [32, 41], 'Smital,': [33], 'Yvonne': [34], 'Martin,': [36], 'Andre': [37], 'G.': [38], 'Pernet,': [39], 'Paul': [40], 'Bunnell,': [42], 'Souheir': [43], 'E.': [44], 'El': [45], 'Masry,': [46], 'Patrick': [48], 'DodgeCite': [50], 'this:': [51], 'Med.': [53], 'Chem.': [54], '1984,': [55], '27,': [56], '12,': [57], '1579–1587Publication': [58], 'Date': [59], '(Print):December': [60], '1,': [61], '1984Publication': [62], 'History': [63], 'Published': [64], 'online1': [65], 'May': [66], '2002Published': [67], 'inissue': [68], '1': [69], 'December': [70], '1984https://pubs.acs.org/doi/10.1021/jm00378a010https://doi.org/10.1021/jm00378a010research-articleACS': [71], 'PublicationsRequest': [72], 'reuse': [73], 'permissionsArticle': [74], 'Views349Altmetric-Citations10LEARN': [75], 'ABOUT': [76], 'THESE': [77], 'METRICSArticle': [78], 'Views': [79], 'are': [80, 103, 116], 'the': [81, 112, 117, 146, 157, 170, 173, 178, 185, 191], 'COUNTER-compliant': [82], 'sum': [83], 'full': [85], 'text': [86], 'article': [87, 151], 'downloads': [88], 'since': [89], 'November': [90], '2008': [91], '(both': [92], 'PDF': [93], 'HTML)': [95], 'across': [96], 'all': [97], 'institutions': [98], 'individuals.': [100], 'These': [101], 'metrics': [102], 'regularly': [104], 'updated': [105, 129], 'to': [106, 111], 'reflect': [107], 'usage': [108], 'leading': [109], 'up': [110], 'last': [113], 'few': [114], 'days.Citations': [115], 'number': [118], 'other': [120], 'articles': [121], 'citing': [122], 'this': [123], 'article,': [124], 'calculated': [125], 'by': [126], 'Crossref': [127, 135], 'daily.': [130], 'Find': [131, 181], 'more': [132, 182], 'information': [133, 183], 'about': [134, 169], 'citation': [136], 'counts.The': [137], 'Altmetric': [138, 186], 'Attention': [139, 187], 'Score': [140, 188], 'is': [141, 193], 'a': [142, 149, 162], 'quantitative': [143], 'measure': [144], 'attention': [147], 'that': [148], 'research': [150], 'has': [152], 'received': [153], 'online.': [154], 'Clicking': [155], 'on': [156, 184], 'donut': [158], 'icon': [159], 'will': [160], 'load': [161], 'page': [163], 'at': [164], 'altmetric.com': [165], 'with': [166, 201], 'additional': [167], 'details': [168], 'score': [171, 192], 'social': [174], 'media': [175], 'presence': [176], 'for': [177], 'given': [179], 'article.': [180], 'how': [190], 'calculated.': [194], 'Share': [195, 210], 'Add': [196], 'toView': [197], 'InAdd': [198], 'Full': [199], 'Text': [200], 'ReferenceAdd': [202], 'Description': [203], 'ExportRISCitationCitation': [204], 'abstractCitation': [206], 'referencesMore': [208], 'Options': [209], 'onFacebookTwitterWechatLinked': [211], 'InRedditEmail': [212], 'Other': [213], 'access': [214], 'optionsGet': [215], 'e-Alertsclose': [216], 'Get': [217], 'e-Alerts': [218]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2032571621', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-10T03:46:11.335931', 'created_date': '2016-06-24'}