Title: Development of malignant hyperthermia post-cardiopulmonary bypass during surgery for mitral valve replacement
Abstract: INITIALLY DESCRIBED BY Denborough et al 1 Denborough M.A. Lovell R.R.H. Anesthetic Deaths in a family. Lancet. 1960; 2: 45 Abstract Scopus (329) Google Scholar in 1962, malignant hyperthermia (MH) represents a hypermetabolic reaction to inhalation anesthetics and succinylcholine. Its incidence is estimated to be 1/15,000 in pediatric patients and 1/50,000 in adult patients. 2 Jurkatt-Rott K. McCarthy T. Lehmann-Horn F. Genetics and pathogenetics of malignant hyperthermia. Muscle Nerve. 2000; 23: 4-17 Crossref PubMed Scopus (283) Google Scholar , 3 Starzis K.P. Fox A.W. Malignant hyperthermia A review of published cases. Anesth Analg. 1993; 77: 297-304 Crossref PubMed Scopus (135) Google Scholar Clinical features of malignant hyperthermia include tachycardia, increases in oxygen (O2) consumption and carbon dioxide (CO2) production, unstable blood pressure, arrhythmias, and an elevated body temperature. 2 Jurkatt-Rott K. McCarthy T. Lehmann-Horn F. Genetics and pathogenetics of malignant hyperthermia. Muscle Nerve. 2000; 23: 4-17 Crossref PubMed Scopus (283) Google Scholar , 3 Starzis K.P. Fox A.W. Malignant hyperthermia A review of published cases. Anesth Analg. 1993; 77: 297-304 Crossref PubMed Scopus (135) Google Scholar , 4 Cone A.M. Schneider M. Massive rhabdomyolysis following cardiopulmonary bypass. Anesth Intens Care. 1995; 23: 721-724 PubMed Google Scholar MH-susceptible patients may not experience the syndrome during their first anesthetic. 3 Starzis K.P. Fox A.W. Malignant hyperthermia A review of published cases. Anesth Analg. 1993; 77: 297-304 Crossref PubMed Scopus (135) Google Scholar At least 4 cases of MH have occurred during surgery with cardiopulmonary bypass (CPB). 4 Cone A.M. Schneider M. Massive rhabdomyolysis following cardiopulmonary bypass. Anesth Intens Care. 1995; 23: 721-724 PubMed Google Scholar , 5 MacGillivray R.G. Jann H. Vanker E. et al. Development of malignant hyperthermia obscured by cardiopulmonary bypass. Can Anesth Soc J. 1986; 33: 509-514 Crossref PubMed Scopus (26) Google Scholar , 6 Quinn R.D. Pae W.E. McGary S.A. et al. Development of malignant hyperthermia during mitral valve replacement. Ann Thorac Surg. 1992; 53: 1114-1116 Abstract Full Text PDF PubMed Scopus (22) Google Scholar , 7 Lindholm P. Andersen S. Andersen C. et al. Development of malignant hyperthermia during cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2000; 14: 576-578 Abstract Full Text Full Text PDF PubMed Scopus (12) Google Scholar In 1 case, there was a report of massive rhabdomyolysis after CPB, suggesting possible MH involvement, but the possibility of an undiagnosed myopathy as the underlying etiology could not be ruled out. 4 Cone A.M. Schneider M. Massive rhabdomyolysis following cardiopulmonary bypass. Anesth Intens Care. 1995; 23: 721-724 PubMed Google Scholar
Publication Year: 2003
Publication Date: 2003-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 13
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot