Publication Information

{'id': 'https://openalex.org/W2032498911', 'doi': 'https://doi.org/10.1128/jvi.79.15.9970-9981.2005', 'title': 'Herpes Simplex Virus Type 1 Strain HSV1716 Grown in Baby Hamster Kidney Cells Has Altered Tropism for Nonpermissive Chinese Hamster Ovary Cells Compared to HSV1716 Grown in Vero Cells', 'display_name': 'Herpes Simplex Virus Type 1 Strain HSV1716 Grown in Baby Hamster Kidney Cells Has Altered Tropism for Nonpermissive Chinese Hamster Ovary Cells Compared to HSV1716 Grown in Vero Cells', 'publication_year': 2005, 'publication_date': '2005-07-13', 'ids': {'openalex': 'https://openalex.org/W2032498911', 'doi': 'https://doi.org/10.1128/jvi.79.15.9970-9981.2005', 'mag': '2032498911', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16014957', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1181565'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/jvi.79.15.9970-9981.2005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1181565?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040323103', 'display_name': 'Joe Conner', 'orcid': 'https://orcid.org/0000-0001-9153-1576'}, 'institutions': [{'id': 'https://openalex.org/I2802050120', 'display_name': 'Southern General Hospital', 'ror': 'https://ror.org/04wvkky61', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800201399', 'https://openalex.org/I2802050120']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Joe Conner', 'raw_affiliation_strings': ['Crusade Laboratories Ltd., Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Rd., Glasgow G51 4TF, Scotland, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Crusade Laboratories Ltd., Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Rd., Glasgow G51 4TF, Scotland, United Kingdom', 'institution_ids': ['https://openalex.org/I2802050120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001010613', 'display_name': 'Frazer J. Rixon', 'orcid': None}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Frazer J. Rixon', 'raw_affiliation_strings': ['MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, Scotland, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, Scotland, United Kingdom', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5087430495', 'display_name': 'Stuart M. Brown', 'orcid': 'https://orcid.org/0000-0002-0906-9907'}, 'institutions': [{'id': 'https://openalex.org/I2802050120', 'display_name': 'Southern General Hospital', 'ror': 'https://ror.org/04wvkky61', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800201399', 'https://openalex.org/I2802050120']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S. Moira Brown', 'raw_affiliation_strings': ['Crusade Laboratories Ltd., Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Rd., Glasgow G51 4TF, Scotland, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Crusade Laboratories Ltd., Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Rd., Glasgow G51 4TF, Scotland, United Kingdom', 'institution_ids': ['https://openalex.org/I2802050120']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.625, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.744191, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '79', 'issue': '15', 'first_page': '9970', 'last_page': '9981'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10625', 'display_name': 'Herpesvirus Infections and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10625', 'display_name': 'Herpesvirus Infections and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vero-cell', 'display_name': 'Vero cell', 'score': 0.8307666}, {'id': 'https://openalex.org/keywords/tissue-tropism', 'display_name': 'Tissue tropism', 'score': 0.59978163}], 'concepts': [{'id': 'https://openalex.org/C175656101', 'wikidata': 'https://www.wikidata.org/wiki/Q56646', 'display_name': 'Chinese hamster ovary cell', 'level': 3, 'score': 0.95253026}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8729634}, {'id': 'https://openalex.org/C33263850', 'wikidata': 'https://www.wikidata.org/wiki/Q4838438', 'display_name': 'Baby hamster kidney cell', 'level': 3, 'score': 0.86431}, {'id': 'https://openalex.org/C89138240', 'wikidata': 'https://www.wikidata.org/wiki/Q3066564', 'display_name': 'Vero cell', 'level': 3, 'score': 0.8307666}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.70856166}, {'id': 'https://openalex.org/C2781196997', 'wikidata': 'https://www.wikidata.org/wiki/Q655331', 'display_name': 'Herpes simplex virus', 'level': 3, 'score': 0.6702686}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.66593754}, {'id': 'https://openalex.org/C33602714', 'wikidata': 'https://www.wikidata.org/wiki/Q7809666', 'display_name': 'Tissue tropism', 'level': 4, 'score': 0.59978163}, {'id': 'https://openalex.org/C35693153', 'wikidata': 'https://www.wikidata.org/wiki/Q239762', 'display_name': 'Tropism', 'level': 3, 'score': 0.57008547}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.5658981}, {'id': 'https://openalex.org/C2778575167', 'wikidata': 'https://www.wikidata.org/wiki/Q6573', 'display_name': 'Hamster', 'level': 2, 'score': 0.5573409}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.39922982}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09048501}], 'mesh': [{'descriptor_ui': 'D018259', 'descriptor_name': 'Herpesvirus 1, Human', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002522', 'descriptor_name': 'Chlorocebus aethiops', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018259', 'descriptor_name': 'Herpesvirus 1, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013045', 'descriptor_name': 'Species Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014709', 'descriptor_name': 'Vero Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/jvi.79.15.9970-9981.2005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1181565', 'pdf_url': 'https://europepmc.org/articles/pmc1181565?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1181565', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16014957', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1181565', 'pdf_url': 'https://europepmc.org/articles/pmc1181565?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1542045638', 'https://openalex.org/W1919588248', 'https://openalex.org/W1979211181', 'https://openalex.org/W1992512657', 'https://openalex.org/W1995459626', 'https://openalex.org/W1997221411', 'https://openalex.org/W2001371234', 'https://openalex.org/W2008486572', 'https://openalex.org/W2009821572', 'https://openalex.org/W2021707562', 'https://openalex.org/W2031791450', 'https://openalex.org/W2046711643', 'https://openalex.org/W2053501505', 'https://openalex.org/W2081050915', 'https://openalex.org/W2092235329', 'https://openalex.org/W2099806165', 'https://openalex.org/W2106604059', 'https://openalex.org/W2119827521', 'https://openalex.org/W2126625208', 'https://openalex.org/W2130363568', 'https://openalex.org/W2154726646', 'https://openalex.org/W2156857727', 'https://openalex.org/W2166673821', 'https://openalex.org/W2171398804', 'https://openalex.org/W4229510242'], 'related_works': ['https://openalex.org/W4387743624', 'https://openalex.org/W2884776651', 'https://openalex.org/W2384093552', 'https://openalex.org/W2174387488', 'https://openalex.org/W2001397790', 'https://openalex.org/W1986002187', 'https://openalex.org/W1971663397', 'https://openalex.org/W1940240577', 'https://openalex.org/W1502770178', 'https://openalex.org/W138586086'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Chinese': [1], 'hamster': [2, 71], 'ovary': [3], '(CHO)': [4], 'cells': [5, 11, 30, 61, 78, 110, 141, 189], 'are': [6, 96], 'traditionally': [7], 'regarded': [8], 'as': [9, 20, 175], 'nonpermissive': [10, 156], 'for': [12, 113], 'herpes': [13], 'simplex': [14], 'virus': [15, 66, 137, 171], 'type': [16], '1': [17], '(HSV-1)': [18], 'infection': [19], 'they': [21], 'lack': [22], 'the': [23, 35, 49, 65, 132, 170], 'specific': [24], 'entry': [25], 'receptors,': [26], 'and': [27, 88, 92, 161], 'modified': [28], 'CHO': [29, 60, 77, 101, 128, 140, 188, 196], 'have': [31], 'been': [32], 'instrumental': [33], 'in': [34, 40, 69, 83, 154], 'identification': [36], 'of': [37, 76, 85, 107, 109, 120, 127, 149, 169], 'HSV-1': [38, 50], 'receptors': [39], 'numerous': [41], 'studies.': [42], 'In': [43, 98], 'this': [44, 124], 'report': [45], 'we': [46], 'demonstrate': [47], 'that': [48, 131], 'strain': [51], '17+': [52], 'variant': [53], 'HSV1716': [54, 81, 115, 150], 'is': [55, 67, 162], 'able': [56], 'to': [57, 104, 125, 138, 193], 'infect': [58, 139, 194], 'unmodified': [59], 'but': [62], 'only': [63], 'if': [64], 'propagated': [68, 177], 'baby': [70], 'kidney': [72], '(BHK)': [73], 'cells.': [74, 200], 'Infection': [75], 'by': [79, 135], 'BHK-propagated': [80, 114, 136], 'results': [82], 'expression': [84], 'immediate-early,': [86], 'early,': [87], 'late': [89], 'viral': [90], 'genes,': [91], 'infectious': [93], 'progeny': [94], 'virions': [95], 'produced.': [97], 'normally': [99], 'cultured': [100], 'cells,': [102, 129, 174], 'up': [103], 'a': [105], 'maximum': [106], '50%': [108], 'were': [111, 190], 'permissive': [112], 'infection,': [116], 'with': [117], '24': [118], 'h': [119], 'serum': [121], 'starvation': [122], 'increasing': [123], '100%': [126], 'suggesting': [130], 'mechanism': [133], 'used': [134], 'was': [142, 151], 'cell': [143, 159, 184], 'cycle': [144], 'dependent.': [145], 'The': [146], 'altered': [147], 'tropism': [148], 'also': [152], 'evident': [153], 'another': [155], 'mouse': [157, 198], 'melanoma': [158, 183, 199], 'line': [160], 'an': [163], 'exclusive': [164], 'property': [165], 'resulting': [166], 'from': [167], 'propagation': [168], 'using': [172], 'BHK': [173], 'viruses': [176], 'on': [178], 'Vero,': [179], 'C8161': [180], '(a': [181], 'human': [182], 'line),': [185], 'or': [186, 197], 'indeed,': [187], 'completely': [191], 'unable': [192], 'either': [195]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2032498911', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-18T11:03:28.535474', 'created_date': '2016-06-24'}