Title: Correlation of serum binding of penicillins with partition coefficients
Abstract: The extent of binding of penicillins to human serum is shown to be dependent on the hydrophobic character of their side-chains, as expressed by a partition coefficient function Σπ, calculated using the substituent constant π developed by Hansch et al. Regression analysis gives a good correlation with Σπ for the binding of seventy nine penicillins. The binding of seven of these penicillins is also correlated with their measured partition coefficients and this correlation indicates some anomalies in the Σπ values. These anomalies are discussed in terms of interaction between functional groups in the side-chains and either the amide group or the (β-lactam ring. The relevance of the correlations to the mechanism of binding of penicillins to serum albumin is discussed.
Publication Year: 1967
Publication Date: 1967-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 118
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