Title: INFLUENCE OF INSULIN AND CORTISONE ON HEPATIC AND ADIPOSE TISSUE METABOLISM OF RATS<sup>1</sup>
Abstract: Rats received 2.5 mg. and 5 mg. of cortisone acetate and⁄or various amounts of protamine zinc insulin for 4 and 14 days, respectively. Insulin produced markedty accelerated oxidation of, and lipogenesis from, radio glucose by surviving liver and adipose tissue. The effect of liver was temporary; adipose tissue metabolism remained elevated throughout the experiment. Pre-trcatment with cortisone diminished oxidation and lipogenesis in both tissues. After simultaneous administration of both hormones, the insulin effect was the prevailing one. Insulin stimulated adipose tissue metabolism in vitro to the same degree as after administration in vivo. It is theorized that the adiposity seen in hyperadrenocorticism may be caused by the prevailing effect of insulin on adipose tissue growth and adipose tissue lipogenesis. IN AN earlier communication it was shown that insulin administration accelerates fat deposition in, and growth of, adipose tissue. This effect is only moderately and inconsistently diminished by simultaneous cortisone injections
Publication Year: 1958
Publication Date: 1958-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 92
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