Publication Information

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'https://openalex.org/W2790556458', 'https://openalex.org/W2596972615', 'https://openalex.org/W2516702800', 'https://openalex.org/W2483753814', 'https://openalex.org/W2386696410', 'https://openalex.org/W2374825565', 'https://openalex.org/W2359344108', 'https://openalex.org/W2357001764', 'https://openalex.org/W2349938184', 'https://openalex.org/W2138063897', 'https://openalex.org/W2088962492', 'https://openalex.org/W2011570852', 'https://openalex.org/W137520803'], 'abstract_inverted_index': {'Intervertebral': [0], 'disc': [1, 64, 72, 116, 123, 147], 'degenerative': [2], '(IVDD)': [3], 'is': [4, 41], 'a': [5, 11, 22, 45], 'common': [6], 'orthopaedic': [7], 'condition': [8, 143], 'characterized': [9], 'by': [10, 79, 145], 'series': [12], 'of': [13, 31, 70, 93, 122, 132], 'cellular,': [14], 'biochemical,': [15], 'structural': [16], 'and': [17, 38, 100], 'functional': [18], 'changes': [19], 'that': [20], 'imparts': [21], 'large': [23], 'socioeconomic': [24], 'impact': [25], 'on': [26], 'healthcare': [27], 'system.': [28], 'Progressive': [29], 'loss': [30], 'normal': [32, 56], 'extracellular': [33], 'matrix': [34, 57], 'constituents,': [35], 'namely': [36], 'proteoglycans': [37], 'water': [39], 'content,': [40], 'thought': [42], 'to': [43, 48, 52, 110], 'be': [44], 'key': [46], 'contributor': [47], 'IVDD.': [49], 'The': [50], 'ability': [51], 'sustain': [53], 'or': [54, 62, 113, 136, 149], 'augment': [55], 'composition': [58], 'may': [59], 'slow': [60, 112], 'down': [61], 'reverse': [63, 115], 'degeneration.': [65, 117], 'Traditional': [66], 'concepts': [67], 'for': [68, 129, 140], 'treatment': [69, 88], 'lumbar': [71, 84], 'degeneration': [73, 124], 'have': [74, 103], 'aimed': [75], 'at': [76], 'symptomatic': [77], 'relief': [78], 'limiting': [80], 'motion': [81], 'in': [82, 108], 'the': [83, 119, 127, 130, 151], 'spine,': [85], 'but': [86], 'novel': [87], 'strategies': [89], 'involving': [90], 'direct': [91], 'injection': [92], 'active': [94], 'substance,': [95], 'stem': [96], 'cells,': [97], 'growth': [98], 'factors': [99], 'gene': [101], 'therapy': [102], 'been': [104], 'attracting': [105], 'more': [106], 'attention': [107], 'respect': [109], 'prevent,': [111], 'even': [114], 'Understanding': [118], 'pathophysiological': [120], 'basis': [121], 'will': [125], 'lay': [126], 'foundation': [128], 'emergence': [131], 'exciting': [133], 'new': [134], 'regenerative': [135], 'reparative': [137], 'biological': [138], 'treatments': [139], 'this': [141], 'debilitating': [142], 'either': [144], 'inducing': [146], 'regeneration': [148], 'replacing': [150], 'degenerated': [152], 'disc.': [153]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031720324', 'counts_by_year': [], 'updated_date': '2024-12-08T21:50:27.534954', 'created_date': '2016-06-24'}