Publication Information

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853, 867, 1005, 1015, 1034, 1064, 1069, 1175, 1191, 1199, 1233, 1245, 1319, 1369, 1447, 1451, 1525, 1533, 1591, 1599, 1606, 1616, 1622, 1636, 1643, 1668, 1715, 1720, 1741, 1746, 1853, 1887, 1898, 1903, 1906, 1947, 1955, 1964, 1973, 1982, 2092, 2147, 2371, 2391, 2483, 2508, 2525, 2538, 2546, 2558, 2770, 2773, 2842, 2864, 2893, 2900, 2907, 2913, 2939, 2953, 3146, 3181, 3193, 3198, 3247, 3277, 3320, 3343, 3380, 3386, 3456, 3482, 3485, 3513, 3532, 3548, 3558, 3569, 3617, 3620, 3634, 3647, 3667, 3675, 3684, 3691, 3699, 3706, 3711, 3717, 3729, 3737, 3759, 3785, 3809, 3818, 3843, 3849, 3855, 3861, 3868, 3874, 3881, 3896, 3910, 3944, 3956, 3982, 3993, 4028, 4033, 4050, 4061, 4077, 4089, 4123, 4165, 4187, 4214, 4230, 4290, 4293, 4338, 4371, 4383, 4389, 4411, 4418], 'smooth': [7, 13, 219, 225, 428, 438, 442, 625, 1088], 'muscle': [8, 14, 220, 226, 429, 439, 499, 626, 1089], '(SM)': [9, 221], 'genes': [10, 222, 614, 1638], 'in': [11, 35, 55, 194, 223, 247, 267, 406, 485, 565, 582, 718, 749, 798, 820, 1001, 1030, 1177, 1187, 1312, 1315, 1603, 1610, 1664, 1788, 1812, 1837, 1932, 1997, 2008, 2036, 2222, 2257, 2283, 2357, 2438, 2450, 2572, 2635, 2670, 2697, 2716, 2904, 2973, 3039, 3042, 3059, 3084, 3089, 3136, 3178, 3252, 3257, 3264, 3301, 3392, 3539, 3603, 3658, 3680, 3703, 3770, 3826, 3834, 3878, 3898, 4153, 4160, 4204, 4223, 4248, 4257, 4273, 4282, 4342, 4426], 'vascular': [12, 224, 427, 437], 'cells': [15, 174, 227, 386, 430, 803, 1807, 1991, 2164, 2213, 2251, 2280, 2753, 2762, 3021, 3023, 3051, 3092, 3123, 3162, 3321, 3436, 3648, 3761, 4108, 4127, 4283, 4308], 'and': [16, 50, 127, 151, 228, 262, 339, 363, 484, 493, 497, 505, 638, 676, 713, 759, 808, 873, 1012, 1081, 1092, 1150, 1195, 1266, 1276, 1357, 1372, 1444, 1624, 1627, 1671, 1685, 1687, 1758, 1763, 1776, 1783, 1828, 2005, 2034, 2049, 2055, 2106, 2144, 2165, 2173, 2205, 2237, 2268, 2315, 2355, 2368, 2395, 2418, 2520, 2541, 2567, 2581, 2624, 2652, 2686, 2689, 2718, 2728, 2839, 2897, 2931, 2994, 3029, 3054, 3064, 3127, 3160, 3176, 3230, 3268, 3309, 3439, 3466, 3489, 3534, 3544, 3560, 3625, 3688, 3753, 3787, 3823, 3952, 4021, 4069, 4093, 4136, 4167, 4190, 4247, 4275, 4305, 4373, 4403], 'blocks': [17, 229], 'induction': [18, 163, 230, 375, 3973, 4032, 4220, 4410], 'by': [19, 31, 93, 210, 231, 243, 305, 422, 870, 1374, 1659, 1921, 2177, 2219, 2232, 2255, 2448, 2480, 2522, 2587, 2743, 2848, 2877, 3190, 3219, 3273, 3281, 3334, 3353, 3477, 3551, 3555, 3580, 3649, 3701, 3757, 3775, 3839, 3974, 4025, 4058, 4112, 4142, 4172, 4414], 'arginine': [20, 232, 445], 'vasopressin': [21, 233], '(AVP).': [22, 234], 'We': [23, 235, 1612, 1649, 3978], 'have': [24, 158, 236, 370, 804, 1271, 1517], 'previously': [25, 237, 1786, 2059, 2181, 2796], 'demonstrated': [26, 238], 'that': [27, 200, 239, 412, 566, 583, 609, 716, 745, 1171, 1258, 1633, 3341, 3453, 3586, 3694, 4400], 'suppression': [28, 205, 240, 417, 1190, 1244, 1635, 3848, 4388], 'SM-α-actin': [30, 126, 242, 338, 661, 704, 856, 1176, 1192, 1246, 1623, 1703, 1856, 1949, 3740, 3750, 3780, 3815, 3960, 4044, 4166, 4189, 4252, 4274, 4320, 4412], 'PDGF-BB': [32, 244, 2274], 'is': [33, 245, 480, 563, 670, 741, 1183, 1639, 3345, 3458, 3475, 3904], 'mediated': [34, 246, 1184, 1250, 1640, 3346, 3460], 'part': [36, 248, 1188], 'through': [37, 249, 1067, 1189, 1251, 1530, 1641, 3347, 3462], 'a': [38, 62, 72, 79, 102, 112, 250, 274, 284, 291, 314, 324, 514, 517, 707, 719, 742, 1062, 1252, 1522, 1644, 1652, 1713, 1738, 1838, 1860, 1893, 1924, 1965, 2325, 2336, 2451, 2636, 2768, 2857, 2961, 3166, 3196, 3204, 3253, 3294, 3298, 3306, 3327, 3348, 3483, 3486, 3490, 3618, 3621, 3626, 3655, 3778, 3805, 3846, 3871, 3890, 3990, 4038, 4161, 4423], 'Ras-dependent': [39, 251], 'pathway.': [40, 252, 1242, 1648], 'This': [41, 185, 253, 397, 1181], 'study': [42, 254, 1593], 'examined': [43, 255, 791, 3726, 3979], 'the': [44, 120, 135, 195, 256, 332, 347, 407, 486, 507, 592, 604, 611, 619, 664, 671, 677, 792, 815, 854, 916, 920, 1006, 1016, 1031, 1075, 1200, 1240, 1316, 1324, 1363, 1367, 1448, 1597, 1600, 1614, 1620, 1630, 1665, 1854, 1888, 1948, 1956, 2050, 2098, 2103, 2107, 2111, 2142, 2148, 2166, 2178, 2276, 2340, 2352, 2481, 2523, 2559, 2736, 2771, 2836, 2843, 2862, 2951, 3091, 3118, 3122, 3161, 3378, 3463, 3528, 3540, 3561, 3637, 3682, 3689, 3697, 3715, 3718, 3727, 3730, 3735, 3760, 3814, 3835, 3853, 3866, 3879, 3900, 3907, 3911, 3945, 3949, 3959, 3972, 3980, 3994, 4043, 4086, 4237, 4262, 4270, 4334, 4380], 'role': [45, 257, 1598, 3379, 3716, 3867, 4425], 'phosphatidylinositol': [47, 259, 452, 1079, 1280, 1321, 1344, 2470, 2531, 3535, 3549, 3577], '3-kinase': [48, 260, 1281], '(PI3K)y': [49, 261], 'its': [51, 263, 755, 1035], 'downstream': [52, 264, 1237, 3872, 4381], 'effector,': [53, 265], 'Akt,': [54, 67, 266, 279, 1682, 3387], 'regulating': [56, 268], 'SM': [57, 207, 269, 419, 1023, 3862, 3986, 4053, 4296], 'gene': [58, 208, 270, 420, 796, 1608, 3723, 3883, 4065, 4391], 'expression.': [59, 129, 271, 341, 4253, 4392], 'PDGF': [60, 76, 95, 124, 272, 288, 307, 336, 1172, 1264, 2350, 2757, 3014, 3172, 3184, 3214, 3296, 3440, 3464, 3607, 3651, 3687, 3702, 3738, 3748, 3782, 3844, 4143, 4157, 4193, 4254], 'caused': [61, 70, 78, 101, 273, 282, 290, 313, 3654, 3845], 'rapid': [63, 275], 'sustained': [64, 80, 276, 292, 3233, 3299, 3565], 'activation': [65, 104, 146, 201, 277, 316, 358, 413, 1014, 1068, 1198, 1642, 3342, 3391, 3512, 3692, 3698, 4417], 'whereas': [68, 98, 280, 310, 3305, 4192, 4416], 'AVP': [69, 281, 2272, 2348, 3008, 3182, 3250, 3315, 3443, 3573, 3609, 3653, 3975, 4015, 4031, 4178, 4184, 4219, 4241], 'only': [71, 283, 3662], 'small': [73, 285], 'transient': [74, 286, 1844, 3263, 3308, 4266], 'increase.': [75, 287, 4163], 'selectively': [77, 143, 289, 355], 'stimulation': [81, 293, 3223, 3231, 3316, 3455, 3559, 3570, 3610, 3668, 4144, 4158], 'p85/p110α': [83, 295, 3685, 3695, 3707, 3832], 'PI3K.': [84, 109, 296, 321], 'In': [85, 297, 836, 1055, 3244, 3422, 4181, 4207, 4232], 'contrast,': [86, 298, 3245], 'p85/110β': [87, 299], 'PI3K': [88, 114, 300, 326, 1526, 1757, 2343, 2392, 2465, 3175, 3328, 3533, 3597, 3615, 3676, 3708, 3731, 3833, 3876], 'activity': [89, 301, 869, 1194, 2321, 3285, 3303, 3537, 3828, 3877, 4019, 4036, 4278], 'was': [90, 186, 302, 398, 1594, 1704, 1712, 1727, 1737, 2139, 2157, 2196, 2322, 2376, 2532, 2562, 2846, 2875, 2882, 2942, 3105, 3188, 3225, 3232, 3261, 3279, 3312, 3444, 3553, 3563, 3661, 3755, 4023, 4138, 4217, 4221, 4279], 'not': [91, 303, 1260, 3430, 3442, 3468, 3575, 4116, 4139, 4421], 'altered': [92, 304], 'either': [94, 306, 2754, 3006, 3606, 3650, 4177], 'or': [96, 115, 171, 308, 327, 383, 629, 969, 1884, 1952, 1987, 2017, 2273, 2349, 2761, 3012, 3017, 3022, 3183, 3519, 3608, 3652, 4179, 4307, 4323], 'AVP,': [97, 309, 444, 4415], 'both': [99, 311, 1010, 3821, 4188, 4208, 4215, 4258, 4401], 'agents': [100, 312], 'delayed': [103, 315, 3656], 'Class': [106, 318, 1278, 3471, 3613], 'IB': [107, 319, 3614], 'p101/110γ': [108, 320], 'Expression': [110, 140, 322, 352, 1731, 1753, 3817, 4027], 'gain-of-function': [113, 325, 2765, 3026], 'myristoylated': [116, 328, 1734, 2215, 3807], 'Akt': [117, 329, 1441, 1646, 1655, 1735, 2096, 2216, 2240, 2284, 2319, 2358, 2766, 3027, 3177, 3187, 3194, 3206, 3217, 3278, 3302, 3332, 3344, 3390, 3457, 3700, 3858, 3869, 3897, 3983, 4051, 4366, 4384], '(myr-Akt)': [118, 330, 1736, 3914], 'mimicked': [119, 331], 'inhibitory': [121, 136, 333, 348], 'effect': [122, 137, 334, 349, 1182], 'on': [125, 337, 603, 2477, 2564, 2960, 2999, 3721, 3739, 3965, 3984, 4052, 4295], 'SM22α': [128, 340, 1019, 1625, 1711, 1889, 1957, 2844, 3995, 4017, 4034, 4168, 4245, 4276, 4324], 'Pretreatment': [130, 342], 'with': [131, 188, 343, 400, 757, 1923, 1961, 2000, 2011, 2016, 2031, 2198, 2207, 2234, 2271, 2324, 2347, 2386, 2415, 2420, 2469, 2535, 2543, 2548, 2592, 2692, 2723, 2756, 2867, 2890, 3007, 3013, 3032, 3056, 3068, 3073, 3095, 3129, 3152, 3238, 3288, 3314, 3322, 3434, 3524, 3590, 3599, 3641, 3744, 3777, 3804, 3813, 3889, 3948, 3958, 4042, 4126, 4130, 4261, 4265, 4268, 4311, 4319], 'LY': [132, 344, 3323, 3765, 3790], '294002': [133, 345, 3324, 3766, 3791], 'reversed': [134, 346, 3794], 'PDGF.': [139, 211, 351, 423, 3840, 4026, 4180], 'myr-Akt': [142, 172, 354, 384, 3957, 4029, 4062, 4286, 4294, 4302], 'inhibited': [144, 356, 3971, 4030, 4251, 4255], 'AVP-induced': [145, 357], 'c-Jun': [148, 360, 455], 'N-terminal': [149, 361, 456], 'kinase': [150, 362, 1077, 1360, 2285, 2320, 2359, 2484, 3284, 3536, 3947], 'p38': [152, 364, 4374, 4404], 'mitogen-activated': [153, 365, 463], 'protein': [154, 366, 744, 1205, 1359, 2372, 3771, 3946, 4054, 4169], 'kinases,': [155, 367, 3480], 'which': [156, 368, 862, 1311, 2834, 3208, 3260, 3474, 3660, 3899, 4226, 4235, 4386], 'we': [157, 369, 3388, 3725], 'shown': [159, 371, 1273, 1519, 3352, 4399], 'are': [160, 372, 502, 640, 809, 863, 915, 1259, 4407], 'critical': [161, 373, 481, 816, 864], 'for': [162, 374, 618, 643, 865, 919, 1629, 1755, 1971, 1994, 2020, 2053, 2209, 2265, 2275, 2351, 2365, 2380, 2403, 2454, 2474, 2514, 2569, 2640, 2664, 2706, 2758, 2853, 2861, 2884, 2987, 3009, 3015, 3044, 3061, 3078, 3100, 3141, 3144, 3686, 4075, 4103, 4409], 'these': [165, 377, 1380], 'genes.': [166, 378], 'Nuclear': [167, 379], 'extracts': [168, 380, 2749, 3516, 3638], 'from': [169, 381, 513, 1122, 1678, 1694, 1706, 1728, 1767, 2327, 2373, 2752, 3517, 4395], 'PDGF-stimulated': [170, 382], 'expressing': [173, 385, 2214, 2764, 3025, 3395, 4210, 4285, 4301], 'showed': [175, 387, 1628, 3595, 4119, 4150], 'reduced': [176, 388, 3820], 'serum': [177, 191, 389, 403, 459, 929, 1833, 2004, 2015, 2264, 2695, 3087, 3098, 3139], 'response': [178, 192, 390, 404, 460, 930, 3562, 3604], 'binding': [180, 392, 917, 1371, 2895], 'to': [181, 393, 509, 516, 587, 681, 811, 1087, 1248, 1274, 1362, 1378, 1520, 1595, 1619, 1662, 1681, 1688, 2378, 2654, 2735, 2832, 2950, 3071, 3112, 3185, 3235, 3249, 3270, 3447, 3605, 3733, 3762, 3789, 3906, 3941, 4037, 4176, 4199, 4243, 4328, 4378], 'SM-specific': [182, 394, 795, 1607, 1637, 3722, 3882, 4390], 'CArG': [183, 395, 860, 913, 1003, 1028, 2838], 'elements.': [184, 396], 'associated': [187, 399], 'appearance': [189, 401], 'cytoplasm.': [196, 408], 'These': [197, 409, 802, 1084, 3450], 'data': [198, 410, 3451], 'indicate': [199, 411, 3452], 'p85/p110α/Akt': [203, 415], 'mediates': [204, 416, 1061, 3696], 'Phenotypic': [424], 'modulation': [425, 597], '(VSMC)': [431], '1The': [432], 'abbreviations': [433], 'used': [434, 2852], 'are:': [435], 'VSMC,': [436, 1056, 3681], 'cell(s);': [440], 'SM,': [441], 'muscle;': [443], 'vasopressin;': [446], 'PDGF,': [447, 1660], 'platelet-derived': [448, 1057], 'factor;': [450, 461], 'PI3K,': [451, 3473], '3-kinase;': [453], 'JNK,': [454, 1683], 'kinase;': [457, 472], 'SRF,': [458], 'MAP,': [462], 'protein;': [464], 'MEM,': [465], 'minimal': [466, 1673, 3963], 'essential': [467, 1674], 'medium;': [468], 'ERK,': [469], 'extracellular': [470], 'signal-regulated': [471], 'myr,': [473], 'myristoylated;': [474], 'PBS,': [475, 3090], 'phosphate-buffered': [476], 'saline;': [477], 'DAPI,': [478], '4′-6-diamino-2-phenylindole.': [479], 'during': [482, 683], 'development': [483, 685], 'onset': [487], 'diseases': [489], 'such': [490, 570, 1352], 'as': [491, 571, 1353, 1785, 2058, 2335, 2338, 2444, 2794, 3195, 3293, 3351, 3382, 3870, 4041], 'atherosclerosis': [492], 'hypertension.': [494], 'Unlike': [495], 'myocardial': [496], 'skeletal': [498], 'cells,': [500, 3035], 'VSMC': [501, 599, 645, 674, 752, 819, 1780, 1912, 2026, 2208, 3248, 3393, 3521, 3800, 3885, 4299], 'highly': [503], 'plastic': [504], 'retain': [506], 'ability': [508, 3180, 3728], 'modulate': [510, 3734], 'their': [511, 1689, 3033], 'phenotype': [512], 'contractile': [515, 628], 'more': [518, 3262, 3307, 4096], 'proliferative': [519], 'synthetic': [520], 'state': [521], '(1Chamley-Campbell': [522], 'J.H.': [523], 'Campbell': [524], 'G.R.': [525], 'Atherosclerosis.': [526], '1981;': [527], '40:': [528], '347-357Abstract': [529], 'Full': [530, 696, 991, 993, 1303, 1432, 1434, 1470, 1472, 1504, 1506, 1555, 1557, 1579, 1581, 2080, 2082, 2816, 2818], 'Text': [531, 697, 992, 994, 1304, 1433, 1435, 1471, 1473, 1505, 1507, 1556, 1558, 1580, 1582, 2081, 2083, 2817, 2819], 'PDF': [532, 698, 995, 1305, 1436, 1474, 1508, 1559, 1583, 2084, 2820], 'PubMed': [533, 654, 699, 732, 783, 845, 890, 908, 943, 964, 996, 1050, 1115, 1145, 1165, 1227, 1306, 1337, 1404, 1437, 1475, 1509, 1560, 1584, 1801, 1879, 2085, 2134, 2191, 2789, 2821, 3371, 3417, 3504, 3935, 4010], 'Scopus': [534, 655, 733, 784, 846, 891, 909, 944, 965, 997, 1051, 1116, 1146, 1166, 1228, 1307, 1338, 1405, 1476, 1510, 1561, 1585, 1802, 1880, 2086, 2135, 2790, 2822, 3372, 3418, 3505, 3936, 4011], '(259)': [535], 'Google': [536, 557, 657, 700, 735, 786, 848, 893, 911, 946, 967, 999, 1053, 1118, 1148, 1168, 1230, 1309, 1340, 1407, 1438, 1478, 1512, 1563, 1587, 1804, 1882, 2088, 2137, 2192, 2792, 2824, 3374, 3420, 3507, 3938, 4013], 'Scholar,': [537, 894, 1408, 1479, 1564], '2Kocher': [538], 'O.': [539], 'Gabbiani': [540, 542], 'F.': [541, 1131, 1213, 1397, 3357, 3403], 'G.': [543, 1455], 'Reidy': [544], 'M.A.': [545], 'Cokay': [546], 'M.S.': [547], 'Peters': [548], 'H.': [549], 'Huttner': [550], 'I.': [551], 'Lab.': [552], 'Invest.': [553], '1991;': [554, 1162], '65:': [555], '459-470PubMed': [556], 'Scholar).': [558, 658, 701, 736, 787, 849, 912, 947, 1054, 1119, 1231, 1341, 1439, 1513, 1588, 1805, 2089, 2193, 2825, 3375, 3421, 3508, 4014], 'Retention': [559], 'this': [561, 1592, 1617, 3514, 3635, 3754, 3795, 4022, 4137, 4427], 'plasticity': [562], 'important': [564], 'it': [567, 577, 584, 669], 'permits': [568], 'processes': [569], 'vessel': [572, 684], 'repair': [573], 'after': [574, 3286, 3566, 3664], 'injury,': [575], 'but': [576, 3441, 3969, 4156], 'may': [578, 746, 3677], 'also': [579, 1025, 1650, 1978, 4149, 4280], 'be': [580, 601, 747, 1249, 3678], 'detrimental': [581], 'increases': [585, 3825, 4152], 'susceptibility': [586], 'atherogenic': [588], 'risk': [589], 'factors.': [590], 'Understanding': [591], 'molecular': [593, 1202], 'control': [594, 610, 3034, 3435, 3518, 4312], 'phenotypic': [596], 'will': [600], 'dependent': [602], 'identification': [605], 'signaling': [607, 1350, 1647, 1656, 2704], 'mechanisms': [608], 'transcription': [612, 927, 1452], 'encoding': [615, 1733, 1850, 1967, 2095, 3892], 'proteins': [616, 1536, 2628, 2896, 4216], 'necessary': [617, 4408], 'differentiated': [620], 'function': [621, 3197], 'VSMC.': [623, 801, 1180, 1611, 3704], 'Several': [624], '(SM)-specific': [627], 'contractile-associated': [630], 'proteins,': [631], 'including': [632, 1074, 1239], 'SM-α-actin,': [633, 3786], 'myosin': [634], 'heavy': [635], 'chain,': [636], 'h-caldesmon,': [637], 'SM-22α,': [639], 'useful': [641], 'markers': [642], 'studying': [644], 'differentiation': [646], '(3Owens': [647], 'G.K.': [648, 726, 902, 1159], 'Physiol.': [649, 779], 'Rev.': [650], '1995;': [651, 940, 1047, 1112, 1300], '75:': [652, 888, 962, 1877], '487-517Crossref': [653], '(1419)': [656], 'Of': [659, 4079], 'these,': [660], 'has': [662, 790, 4201, 4398], 'been': [663, 805, 1272, 1518, 4202], 'most': [665, 672, 813], 'extensively': [666, 3126], 'studied,': [667], 'because': [668, 753], 'abundant': [673], 'protein,': [675], 'first': [678, 1631], 'known': [679], 'marker': [680], 'appear': [682], '(4Fatigati': [686], 'V.': [687, 878, 952, 976, 1129, 1211, 1867, 2065, 2801, 3401], 'Murphy': [688], 'R.A.': [689, 884, 958, 984, 1139, 1221, 1873, 2073, 2809, 3411], 'J.': [690, 776, 777, 882, 938, 956, 985, 1046, 1141, 1223, 1414, 1464, 1497, 1549, 1573, 1797, 1871, 2074, 2186, 2810, 3359, 3413], 'Biol.': [691, 840, 986, 1428, 1465, 1550, 1574, 2075, 2811], 'Chem.': [692, 987, 1466, 1551, 1575, 2076, 2812], '1984;': [693], '259:': [694], '14383-14388Abstract': [695], 'Regulation': [702], 'involves': [706, 1196], 'complex': [708], 'interaction': [709], 'multiple': [711, 1027, 1236, 3673], 'positive': [712], 'negative': [714], 'cis-elements': [715], 'act': [717], 'cell': [720, 1090], 'type-specific': [721], 'fashion': [722], '(5Mack': [723], 'C.P.': [724, 896], 'Owens': [725, 901, 1158], 'Circ.': [727, 885, 903, 959, 1160, 1874, 4005], 'Res.': [728, 886, 904, 960, 1161, 1333, 1875, 2785, 3367, 3500, 4006], '1999;': [729, 1334, 1467, 1501, 1576, 3501], '84:': [730], '852-861Crossref': [731], '(205)': [734], 'SM22α,': [737, 3988, 4191], 'another': [738, 3985, 4094], 'early': [739], 'marker,': [740, 3987], 'calponin-related': [743], 'involved': [748], 'contraction': [750], 'interactions': [756], 'tropomyosin': [758], 'F-actin': [760], '(6Fu': [761], 'Y.': [762, 1109], 'Liu': [763], 'H.W.': [764], 'Forsythe': [765], 'S.M.': [766, 831], 'Kogut': [767], 'P.': [768, 934, 1463, 1489, 1793, 4002], 'McConville': [769], 'J.F.': [770], 'Halayko': [771], 'A.J.': [772], 'Camoretti-Mercado': [773], 'B.': [774, 1328, 1548, 3495], 'Solway': [775], 'Appl.': [778], '2000;': [780, 905, 988, 2077, 2813, 3368], '89:': [781], '1985-1990Crossref': [782], '(108)': [785], 'Our': [788], 'laboratory': [789, 1124, 4397], 'regulation': [793, 866, 1621, 3633, 3880, 4428], 'cultured': [799, 1784, 2998], 'adult': [800], 'widely': [806], 'studied': [807], 'likely': [810, 3459], 'reflect': [812], 'features': [817], 'vivo': [821], '(7Firulli': [822], 'A.B.': [823, 1395], 'Han': [824, 981, 2070, 2806], 'D.': [825, 1383, 1538], 'Kelly-Roloff': [826], 'L.': [827, 3998], 'Koteliansky': [828], 'V.E.': [829], 'Schwartz': [830], 'Olson': [832, 4003], 'E.N.': [833, 4004], 'Miano': [834, 3999], 'J.M.': [835, 4000], 'Vitro': [837], 'Cell': [838, 1332, 1695, 1774, 2045, 2328, 3499], 'Dev.': [839], 'Anim.': [841], '1998;': [842, 1429, 1552], '34:': [843], '217-226Crossref': [844], '(76)': [847], 'The': [850, 1018, 1589, 1806, 1976, 1990, 2023, 2044, 2153, 2212, 2250, 2279, 2409, 2583, 2643, 2660, 2712, 2739, 2990, 3050, 3148, 3841, 4048, 4331], 'proximal': [851, 1032], 'region': [852, 1033, 3992], 'rat': [855, 1178, 1855], 'promoter': [857, 868, 1008, 1036, 1193, 1847, 1857, 1890, 1958, 2845, 3741, 3751, 3827, 3850, 3961, 3967, 3996, 4018, 4035, 4045, 4277, 4297, 4321, 4325], 'contains': [858, 1026], 'two': [859, 3423], 'elements,': [861], 'vasoconstrictor': [871], 'hormones': [872], 'factors': [875, 1453], '(8Van': [876, 950, 1865], 'Putten': [877, 951, 975, 1128, 1210, 1866, 2064, 2800, 3400], 'Li': [879, 953, 1868], 'X.': [880, 954, 1126, 1208, 1869, 3398], 'Maselli': [881, 955, 1870], 'Nemenoff': [883, 957, 983, 1138, 1220, 1872, 2072, 2808, 3410], '1994;': [887, 961, 1876], '1126-1130Crossref': [889, 963, 1878], '(30)': [892, 966, 1881], '9Mack': [895], 'Thompson': [897, 1154], 'M.M.': [898, 1155, 1410], 'Lawrenz-Smith': [899], 'S.': [900, 1135, 1217, 1457, 1566, 1572, 2129, 3365, 3407, 3930], '86:': [906], '221-232Crossref': [907], '(97)': [910], 'elements': [914, 1004], 'sites': [918, 2146], 'MADS': [921], '(MCM1': [922], 'agamous': [923], 'deficiens': [924], 'SRF)': [925], 'box': [926], 'factor,': [928], '(SRF)': [932], '(10Shore': [933], 'Sharrocks': [935], 'A.D.': [936], 'Eur.': [937], 'Biochem.': [939, 1045, 1140, 1222, 1796, 3412], '229:': [941], '1-13Crossref': [942], '(745)': [945], 'Truncation': [948], 'mutations': [949, 971], 'Scholar)': [968, 1000, 1149, 1169, 1883, 2138, 2793], 'point': [970], '(11Garat': [972, 2061, 2797, 4429], 'C.': [973, 980, 1791, 2062, 2069, 2798, 2805, 3361, 4430], 'Van': [974, 1127, 1209, 2063, 2799, 3399, 4431], 'Refaat': [977, 2066, 2802], 'Z.A.': [978, 2067, 2803], 'Dessev': [979, 2068, 2804], 'S.Y.': [982, 2071, 2807], '275:': [989, 2078, 2814], '22537-22543Abstract': [990, 2079, 2815], '(49)': [998, 2087, 2823], 'individual': [1002], 'SMA': [1007], 'abolish': [1009], 'basal': [1011, 3271, 3426, 3822, 3966, 4154, 4212], 'AVP-stimulated': [1013, 3824], 'promoter.': [1017, 3816], 'gene,': [1020], 'like': [1021], 'many': [1022], 'genes,': [1024], 'boxes': [1029, 2841], '(12Kemp': [1037], 'P.R.': [1038, 1389], 'Osbourn': [1039], 'J.K.': [1040], 'Grainger': [1041], 'D.J.': [1042], 'Metcalfe': [1043], 'J.C.': [1044], '310:': [1048], '1037-1043Crossref': [1049], '(41)': [1052], 'variety': [1063], 'biological': [1065], 'effects': [1066, 1085, 3736, 3964, 3981, 4049], 'intracellular': [1070], 'signal': [1071, 3903], 'transduction': [1072], 'pathways': [1073, 1257], 'MAP': [1076, 4375, 4405], 'cascade,': [1078], 'turnover,': [1080], 'calcium': [1082], 'mobilization.': [1083], 'contribute': [1086], 'proliferation': [1091], 'directed': [1093], 'migration': [1094], '(13Bornfeldt': [1095], 'K.E.': [1096], 'Raines': [1097], 'E.W.': [1098], 'Graves': [1099], 'L.M.': [1100], 'Skinner': [1101], 'M.P.': [1102], 'Krebs': [1103], 'E.G.': [1104], 'Ross': [1105], 'R.': [1106, 1546], 'Ann.': [1107], 'N.': [1108, 1570], 'Acad.': [1110, 2126, 3927], 'Sci.': [1111, 2127, 3928], '766:': [1113], '416-430Crossref': [1114], '(186)': [1117], 'Earlier': [1120], 'work': [1121, 4394], 'our': [1123, 3745, 4396], '(14Li': [1125, 1207, 3397], 'Zarinetchi': [1130, 1212, 3402], 'Nicks': [1132, 1214, 3404], 'M.E.': [1133, 1215, 1499, 3405], 'Thaler': [1134, 1216, 3406], 'Heasley': [1136, 1218, 1744, 3408], 'L.E.': [1137, 1219, 3409], '1997;': [1142, 1224, 1401, 2131, 3414, 3932], '327:': [1143, 1225, 3415], '709-716Crossref': [1144, 1226, 3416], '(44)': [1147, 1229, 3419], 'others': [1151], '(15Turla': [1152], 'M.B.': [1153], 'Corjay': [1156], 'M.H.': [1157, 1418], '68:': [1163], '288-299Crossref': [1164], '(85)': [1167], 'reported': [1170], 'suppressed': [1173, 3749, 4024, 4194], 'aortic': [1179, 1779], 'at': [1185, 1323, 1834, 2102, 2110, 2245, 2383, 2406, 2457, 2517, 2631, 2667, 2709, 2887, 2944, 2970, 3047, 3081, 3211, 3227, 3582], 'least': [1186], 'PDGF-induced': [1197, 1604, 3331, 3454, 3546, 3875], 'low': [1201], 'weight': [1203], 'G': [1204, 1514, 1535], 'Ras': [1206, 1234, 3381], 'Activation': [1232, 3276, 3705, 4367], 'engages': [1235], 'effectors,': [1238], 'Raf/MEK/ERK': [1241], 'However,': [1243], 'appeared': [1247], 'Ras-dependent/Raf-independent': [1253], 'pathway': [1254, 1602, 1618, 1657, 3350, 3720, 3837], 'involving': [1255], 'effector': [1256, 3873], 'well': [1261], 'characterized.': [1262], 'Activated': [1263, 1440], 'receptors': [1265, 1516], 'other': [1267, 1983, 3354], 'receptor': [1268, 3465, 3478], 'tyrosine': [1269, 3479], 'kinases': [1270, 4406], 'bind': [1275], 'activate': [1277, 1379, 1521, 3448], 'IA': [1279, 3472], '(PI3K)': [1282], '(16Franke': [1283], 'T.F.': [1284], 'Yang': [1285], 'S.I.': [1286], 'Chan': [1287, 2120, 3921], 'T.O.': [1288, 2121, 3922], 'Datta': [1289], 'K.': [1290], 'Kazlauskas': [1291], 'A.': [1292, 1426, 1481, 1483, 2119, 2130, 3920, 3931], 'Morrison': [1293], 'D.K.': [1294], 'Kaplan': [1295], 'D.R.': [1296, 2185], 'Tsichlis': [1297, 2122, 3923], 'P.N.': [1298, 2123, 3924], 'Cell.': [1299, 1500], '81:': [1301], '727-736Abstract': [1302], '(1838)': [1308], 'Scholar),': [1310, 3939], 'turn': [1313], 'results': [1314, 2584, 4263, 4332], 'local': [1317], 'accumulation': [1318], 'polyphosphoinositide': [1320], '3,4,5-trisphosphate': [1322, 1345, 3550, 3578], 'plasma': [1325, 1364, 3950], 'membrane': [1326, 3951], '(17Vanhaesebroeck': [1327, 3494], 'Waterfield': [1329, 3496], 'M.D.': [1330, 3497], 'Exp.': [1331, 3498], '253:': [1335, 3502], '239-254Crossref': [1336, 3503], '(771)': [1339, 3506], 'Newly': [1342], 'synthesized': [1343], 'recruits': [1346], 'pleckstrin': [1347], 'homology': [1348], 'domain-containing': [1349], 'molecules': [1351, 2705], 'phosphoinositide-dependent': [1354, 1375], 'kinase-1,': [1355], 'Akt/PKB,': [1356], 'possibly': [1358], 'Cζ,': [1361], 'membrane,': [1365], 'where': [1366], 'combination': [1368], 'lipid': [1370], 'phosphorylation': [1373, 3192, 3210, 3218, 3333], 'kinase-1': [1376], 'serves': [1377], 'enzymes': [1381], '(18Stokoe': [1382], 'Stephens': [1384], 'L.R.': [1385], 'Copeland': [1386], 'T.': [1387, 1540, 1542], 'Gaffney': [1388], 'Reese': [1390], 'C.B.': [1391], 'Painter': [1392], 'G.F.': [1393], 'Holmes': [1394], 'McCormick': [1396], 'Hawkins': [1398, 1567], 'P.T.': [1399, 1568], 'Science.': [1400], '277:': [1402], '567-570Crossref': [1403], '(1063)': [1406], '19Chou': [1409], 'Hou': [1411], 'W.': [1412], 'Johnson': [1413], 'Graham': [1415], 'L.K.': [1416], 'Lee': [1417], 'Chen': [1419], 'C.S.': [1420], 'Newton': [1421], 'A.C.': [1422], 'Schaffhausen': [1423], 'B.S.': [1424], 'Toker': [1425], 'Curr.': [1427], '8:': [1430], '1069-1077Abstract': [1431], 'can': [1442], 'phosphorylate': [1443], 'inhibit': [1445], 'members': [1446], 'forkhead': [1449], 'family': [1450], '(20Rena': [1454], 'Guo': [1456], 'Cichy': [1458], 'S.C.': [1459], 'Unterman': [1460], 'T.G.': [1461], 'Cohen': [1462], '274:': [1468, 1577], '17179-17183Abstract': [1469], '(618)': [1477], '21Brunet': [1480], 'Bonni': [1482], 'Zigmond': [1484], 'M.J.': [1485, 1493], 'Lin': [1486], 'M.Z.': [1487], 'Juo': [1488], 'Hu': [1490], 'L.S.': [1491], 'Anderson': [1492], 'Arden': [1494], 'K.C.': [1495], 'Blenis': [1496], 'Greenberg': [1498], '96:': [1502], '857-868Abstract': [1503], '(5509)': [1511], 'protein-coupled': [1515], 'distinct': [1523], 'class': [1524], '(Class': [1527], 'IB,': [1528], 'p101/p110γ)': [1529], 'β/γ': [1531], 'subunits': [1532], 'heterotrimeric': [1534], '(22Leopoldt': [1537], 'Hanck': [1539], 'Exner': [1541], 'Maier': [1543], 'U.': [1544, 2128, 3929], 'Wetzker': [1545], 'Nurnberg': [1547], '273:': [1553], '7024-7029Abstract': [1554], '(183)': [1562], '23Krugmann': [1565], 'Pryer': [1569], 'Braselmann': [1571], '17152-17158Abstract': [1578], '(75)': [1586], 'goal': [1590], 'examine': [1596, 3510], 'PI3K/Akt': [1601, 3719], 'down-regulation': [1605], 'investigated': [1613], 'contribution': [1615], 'time': [1632, 3199, 3584], 'PDGF-BB-induced': [1634], 'PI3K-dependent': [1645, 1654, 3349], 'report': [1651], 'novel': [1653], 'activated': [1658, 3894], 'leading': [1661, 3940], 'changes': [1663, 2740, 3602], 'subcellular': [1666], 'localization': [1667], 'SRF.': [1669], 'Materials—Trypsin/EDTA': [1670], "Eagle's": [1672, 1813, 1998, 2009, 2258], 'medium': [1675, 2223, 3154], '(MEM)': [1676], 'were': [1677, 1692, 1765, 1781, 1810, 1910, 1918, 1992, 2027, 2047, 2217, 2230, 2243, 2252, 2281, 2345, 2363, 2401, 2411, 2436, 2467, 2512, 2579, 2585, 2590, 2629, 2645, 2662, 2714, 2721, 2741, 2750, 2958, 2992, 2997, 3036, 3052, 3093, 3124, 3150, 3163, 3429, 3522, 3587, 3639, 3773, 3801, 3886, 4056, 4073, 4101, 4170, 4316], 'Invitrogen.': [1679], 'Antibodies': [1680], 'p38,': [1684], 'ERK1/2': [1686], 'phosphorylated': [1690], 'forms': [1691, 3674], 'purchased': [1693, 1766], 'Signaling': [1696, 2329], 'Technologies': [1697, 2330], '(Beverly,': [1698, 2331], 'MA).': [1699, 2659], 'Monoclonal': [1700, 1708], 'antibody': [1701, 1709, 2941, 3075, 3110, 3120, 3526, 3592, 3643], 'against': [1702, 1710, 1760, 2388, 2703, 3527, 3593, 3644], 'obtained': [1705, 4264], 'Sigma.': [1707], 'gift': [1714, 1740], 'Dr.': [1716, 1742, 1899], 'Angela': [1717], 'Chiavegato': [1718], '(University': [1719, 1745], 'Padua,': [1721, 1722], 'Italy).': [1723], 'Horseradish': [1724], 'peroxidase-labeled': [1725], 'IgG': [1726], 'Amersham': [1729], 'Biosciences.': [1730], 'plasmid': [1732, 1754, 1966, 3891], 'generous': [1739], 'Lynn': [1743], 'Colorado': [1747], 'Health': [1748], 'Sciences': [1749], 'Center,': [1750], 'Denver,': [1751], 'CO).': [1752], 'myr-p110α': [1756, 3819], 'antibodies': [1759, 2387, 2702, 2720, 2727], 'p110α,': [1761], 'p110β,': [1762, 2394], 'p101': [1764], 'Upstate': [1768], 'Biotechnology,': [1769], 'Inc.': [1770], '(Lake': [1771], 'Placid,': [1772], 'NY).': [1773], 'Culture': [1775], 'Transient': [1777], 'Transfection—Rat': [1778], 'isolated': [1782], 'described': [1787, 2060, 2180, 2795], 'detail': [1789], '(24Caramelo': [1790], 'Tsai': [1792], 'Schrier': [1794], 'R.W.': [1795], '1988;': [1798], '254:': [1799], '625-629Crossref': [1800], '(29)': [1803], '(passages': [1808], '4–12)': [1809], 'grown': [1811], 'MEM': [1814, 1999, 2010, 2259], 'containing': [1815, 2097, 2224, 2260, 2463, 2681, 2700, 2910, 3155], '1': [1816, 2296, 2299, 2309, 2312, 2426, 2665, 2898, 3079, 3567], 'mm': [1817, 2289, 2294, 2297, 2300, 2306, 2310, 2313, 2427, 2430, 2440, 2490, 2495, 2498, 2501, 2550, 2553, 2599, 2604, 2615, 2619, 2674, 2679, 2916, 2921, 2924, 2927, 2977, 2980, 2983], 'l-glutamine,': [1818], '2': [1819, 1953, 2552, 2570, 2618, 2891, 2937, 4148, 4304], 'g/liter': [1820], 'NaHCO3,': [1821], '100': [1822, 1825, 2526, 2549], 'IU/ml': [1823], 'penicillin,': [1824], 'μg/ml': [1826], 'streptomycin,': [1827], '10%': [1829, 2001, 2648], '(v/v)': [1830], 'fetal': [1831, 2002, 2013, 2262], 'calf': [1832, 2003, 2014], '37': [1835], '°C': [1836, 2385, 2519, 2889, 2946], 'humidified': [1839], 'air/CO2': [1840], '(19:1)': [1841], 'atmosphere.': [1842], 'For': [1843, 2934], 'transfections': [1845, 1977], 'measuring': [1846, 3191, 3283], 'activity,': [1848, 3598, 3659, 3752, 3851], 'vectors': [1849], '765': [1851], 'bp': [1852, 1886], 'ligated': [1858, 1891, 2140], 'into': [1859, 1892, 2159], 'promoterless': [1861, 1894], 'luciferase': [1862, 2037, 2054, 4329], 'vector': [1863, 1896, 1969, 2151, 4132, 4313], '(PA3-Luc)': [1864], '505': [1885], 'PA3-Luc': [1895], '(gift': [1897], 'Joseph': [1900], 'Miano,': [1901], 'University': [1902], 'Rochester': [1904], 'School': [1905], 'Medicine,': [1907], 'Rochester,': [1908], 'NY)': [1909], 'used.': [1911], '(2': [1913], '×': [1914, 2633], '106': [1915], 'cells/100': [1916], 'μl)': [1917], 'transiently': [1919, 2024, 3802, 3887, 4317], 'transfected': [1920, 2025, 3888, 4107, 4129, 4310, 4318], 'electroporation': [1922], 'GeneZAPPER': [1925], '(International': [1926], 'Biotechnologies,': [1927], 'Inc.,': [1928, 1940], 'New': [1929], 'Haven,': [1930], 'CT)': [1931], 'Gene': [1933, 3863], 'Pulser': [1934], '0.4-cm': [1935], 'electrode': [1936], 'gap': [1937], 'cuvettes': [1938], '(Genetronics,': [1939], 'San': [1941], 'Diego,': [1942], 'CA)': [1943], 'using': [1944, 2162, 2333, 2647, 2767, 2869, 3107, 3165, 3203, 3291, 3989, 4063], '10': [1945, 2366, 2439, 2475, 2641, 3045, 3763], 'μg': [1946, 1954, 1963, 1981, 2892, 2938], 'promoter-luciferase': [1950], 'construct': [1951, 1959], 'together': [1960], '5': [1962, 1980, 2497, 2506, 3062, 3220, 3556], 'cytomegalovirus-β-galactosidase': [1968], '(Clontech)': [1970], 'normalization': [1972], 'transfection': [1974], 'efficiency.': [1975], 'included': [1979, 2835, 2856], 'plasmids': [1984, 2169], '(myr-Akt,': [1985], 'myr-P110α,': [1986], 'empty': [1988, 4131], 'vector).': [1989], 'incubated': [1993, 2206, 2468, 2691, 3128], '18': [1995], 'h': [1996, 2267, 2382, 2405, 2571, 2666, 2708, 2760, 3011, 3080, 3237, 3568], 'then': [2006, 2028, 2269, 2690, 3037], 'placed': [2007], '0.2%': [2012, 2261], 'without': [2018], 'agonists': [2019], '72': [2021, 3010, 3016], 'h.': [2022, 2211, 2989, 3019], 'washed': [2029, 2715], 'twice': [2030], 'ice-cold': [2032, 2593], 'PBS': [2033, 3043, 3060], 'harvested': [2035, 2282, 2356], 'reporter': [2038], 'lysis': [2039, 2286, 2360, 2416], 'buffer': [2040, 2287, 2417, 2422], '(Promega,': [2041], 'Madison,': [2042], 'WI).': [2043], 'lysates': [2046], 'centrifuged,': [2048], 'supernatants': [2051, 2644], 'assayed': [2052, 2323], 'β-galactosidase': [2056], 'activities': [2057, 3968], 'Stable': [2090], 'Transfection': [2091], 'VSMC—A': [2093], 'cDNA': [2094], 'Src': [2099], 'myristoylation': [2100, 3902], 'sequence': [2101, 3913], 'N': [2104, 3908], 'terminus': [2105, 2113, 3909], 'hemagglutinin': [2108], 'tag': [2109], 'C': [2112], '(25Ahmed': [2114, 3915], 'N.N.': [2115, 3916], 'Grimes': [2116, 3917], 'H.L.': [2117, 3918], 'Bellacosa': [2118, 3919], 'Proc.': [2124, 3925], 'Natl.': [2125, 3926], '94:': [2132, 3933], '3627-3632Crossref': [2133, 3934], '(490)': [2136, 3937], 'between': [2141], 'HindIII': [2143], 'HpaI': [2145], 'retroviral': [2149], 'pLNCX.': [2152], 'resulting': [2154], 'vector,': [2155], 'LNCX-myr-Akt,': [2156], 'packaged': [2158], 'replication-defective': [2160], 'retrovirus': [2161, 2195], '293T': [2163], 'retrovirus-component': [2167], 'SV-ψ–-A-murine': [2170], 'leukemia': [2171, 2175], 'virus': [2172, 2176], 'SV-ψ–-env–-murine': [2174], 'procedure': [2179, 2772], '(26Landau': [2182], 'N.R.': [2183], 'Littman': [2184], 'Virol.': [2187], '1992;': [2188], '66:': [2189], '5110-5113Crossref': [2190], 'Secreted': [2194], 'supplemented': [2197], 'polybrene': [2199], '(8': [2200], 'μg/ml),': [2201], 'filtered': [2202], '(0.45': [2203], 'μm),': [2204, 3326], '48': [2210], 'selected': [2218, 4102], 'culturing': [2220], 'them': [2221], 'G418': [2225], '(500': [2226], 'μg/ml).': [2227], 'Individual': [2228], 'clones': [2229, 4072, 4081, 4209], 'screened': [2231, 4074], 'immunoblotting': [2233, 3776, 4173], 'anti-hemagglutinin,': [2235], 'anti-Akt,': [2236], 'anti-phospho-Akt': [2238], 'antibodies.': [2239], 'Kinase': [2241, 2510], 'Assay—VSMC': [2242, 2344], 'plated': [2244], '1.5': [2246], 'million': [2247], 'cells/60-mm': [2248], 'dish.': [2249], 'made': [2253, 2847], 'quiescent': [2254], 'incubation': [2256], 'bovine': [2263, 2694, 3086, 3097, 3138], '24': [2266, 2962], 'stimulated': [2270, 2755, 3005, 3520], 'indicated': [2277, 2353], 'times.': [2278], '(25': [2288, 2976], 'Tris-HCl,': [2290, 2431, 2491, 2600, 2675], 'pH': [2291, 2432, 2442, 2492, 2596, 2601, 2676, 2918, 2985], '7.5,': [2292, 2493], '150': [2293, 2603, 2920], 'NaCl,': [2295, 2425, 2496, 2605], 'EDTA,': [2298, 2428, 2620, 2925, 2981], 'EGTA,': [2301, 2502], '1%': [2302, 2606, 2609, 3085, 3137], 'Triton': [2303, 3058], 'X-100,': [2304], '2.5': [2305], 'sodium': [2307, 2610, 2616], 'pyrophosphate,': [2308], 'β-glycerolphosphate,': [2311], 'Na3VO4,': [2314, 2623], 'protease': [2316, 2625, 2932], 'inhibitor': [2317, 3732], 'mixture).': [2318], 'kit': [2326], 'MA),': [2332], 'GSK3': [2334, 3292], 'substrate': [2337], 'per': [2339], "manufacturer's": [2341, 2737], 'instructions.': [2342], 'treated': [2346], 'times': [2354, 2414, 3067], 'buffer.': [2361], 'Extracts': [2362], 'microcentrifuged': [2364], 'min,': [2367, 3229], '0.5': [2369, 2500], 'mg': [2370, 2912], 'each': [2374], 'extract': [2375], 'subjected': [2377], 'immunoprecipitation': [2379, 3287], '16–18': [2381], '4': [2384, 2407, 2458, 2710, 2888, 2945, 3236], 'specific': [2389, 3511, 3779], 'isoforms': [2390, 2466], '(p110α,': [2393], 'p101).': [2396], 'Protein': [2397], 'A-Sepharose': [2398], '(Sigma)': [2399], 'beads': [2400, 2410, 2462], 'added': [2402, 2943], '1–2': [2404], '°C.': [2408, 2459, 2711], 'rinsed': [2412, 3053, 3065, 3125], 'three': [2413, 3066, 4339], 'once': [2419, 2534, 2542], 'wash': [2421], '(0.1': [2423], 'm': [2424], '20': [2429, 2445, 2489, 2503, 2515, 2684, 2905, 3142], '7.5).': [2433], 'Phosphatidylinositol': [2434], 'micelles': [2435, 2471], 'prepared': [2437, 2751], 'HEPES,': [2441], '7.4,': [2443, 2677], 'mg/ml': [2446], 'stock': [2447], 'sonication': [2449], 'bath': [2452], 'sonicator': [2453], '15': [2455, 3274], 'min': [2456, 2476, 2516, 2886, 2948, 3046, 3063, 3143, 3557, 3666], 'Washed': [2460], 'Sepharose': [2461], 'immunoprecipitated': [2464, 3523, 3640], '(20': [2472], 'μg/reaction)': [2473], 'ice,': [2478], 'followed': [2479], 'addition': [2482, 2524, 2952, 3842], 'reaction': [2485], 'mix': [2486], '(final': [2487], 'concentration,': [2488], '50': [2494, 2614], 'MgCl2,': [2499], 'μm': [2504, 2622, 3764], 'ATP,': [2505], 'μCi': [2507], '[γ-32P]ATP).': [2509], 'reactions': [2511], 'run': [2513], '25': [2518, 2971], 'stopped': [2521], 'μlof1': [2527], 'n': [2528], 'HCl.': [2529], 'Phosphorylated': [2530], 'extracted': [2533], '160': [2536], 'μl': [2537, 2545, 2557, 2906], 'chloroform:methanol': [2539], '(1:1)': [2540], '80': [2544], 'MeOH': [2547], 'HCl,': [2551], 'EDTA': [2554], '(1:1).': [2555], 'Ten': [2556], 'organic': [2560], 'phase': [2561, 4113], 'spotted': [2563], 'TLC': [2565, 2577], 'plates': [2566, 2578], 'separated': [2568, 2646], 'chloroform:methanol:ammonium': [2573], 'hydroxide': [2574], '(29.5%):water': [2575], '(42:38:4.7:7.3).': [2576], 'dried': [2580, 2993], 'autoradiographed.': [2582, 2995], 'quantitated': [2586, 2742], 'densitometry.': [2588, 2744], 'Immunoblotting—VSMC': [2589], 'lysed': [2591], 'RIPA': [2594], 'buffer,': [2595], '7.4': [2597], '(50': [2598], '7.0,': [2602], 'Nonidet': [2607], 'P-40,': [2608], 'deoxycholate,': [2611], '0.1%': [2612, 2682, 3057], 'SDS,': [2613], 'fluoride,': [2617], '200': [2621], 'inhibitors).': [2626], 'Solubilized': [2627], 'centrifuged': [2630], '14,000': [2632], 'g': [2634], 'microcentrifuge': [2637], '(4': [2638], '°C)': [2639], 'min.': [2642, 3102, 3221, 3275], 'SDS-polyacrylamide': [2649], 'gel': [2650, 2879, 2966], 'electrophoresis': [2651], 'transferred': [2653], 'Immobilon': [2655], 'P': [2656], '(Millipore,': [2657], 'Bedford,': [2658], 'membranes': [2661, 2713], 'blocked': [2663, 3094, 3330, 3756, 4281], 'room': [2668, 3048, 3082], 'temperature': [2669, 3083], 'Tris-buffered': [2671], 'saline': [2672], '(10': [2673, 3325], '140': [2678], 'NaCl)': [2680], 'Tween': [2683], '(TTBS)': [2685], '5%': [2687, 2693, 2964, 3096], 'milk,': [2688], 'albumin': [2696, 3088, 3099, 3140], 'TTBS': [2698], 'solution': [2699], 'primary': [2701], '12–16': [2707], 'TTBS,': [2717], 'bound': [2719], 'visualized': [2722, 3164], 'horseradish': [2724], 'peroxidase-coupled': [2725], 'secondary': [2726, 3119], 'enhanced': [2729, 3942], 'chemiluminescence': [2730], '(PerkinElmer': [2731], 'Life': [2732], 'Sciences)': [2733], 'according': [2734], 'directions.': [2738], 'Electrophoretic': [2745], 'Mobility': [2746], 'Shift': [2747], 'Assay—Nuclear': [2748], '96': [2759, 3018], 'stably': [2763, 3024, 3394, 4128, 4284, 4300, 4309], 'variation': [2769], 'Dignam': [2774], 'et': [2775], 'al.': [2776], '(27Dignam': [2777], 'J.D.': [2778], 'Lebovitz': [2779], 'R.M.': [2780], 'Roeder': [2781], 'R.G.': [2782], 'Nucleic': [2783], 'Acids': [2784], '1983;': [2786], '11:': [2787], '1475-1489Crossref': [2788], '(9174)': [2791], 'A': [2826], 'double-stranded': [2827], '94-bp': [2828], 'DNA': [2829, 2871, 2902], 'piece': [2830], '(–184': [2831], '–92),': [2833], 'near': [2837], 'GC': [2840], 'PCR': [2849, 2854], 'amplification.': [2850], 'Primers': [2851], 'amplifications': [2855], '3′': [2858], 'MluI': [2859], 'site': [2860], 'purpose': [2863], 'fill-in': [2865], 'labeling': [2866, 3072, 3104], '[32P]dCTP': [2868, 2874], 'Klenow': [2870], 'polymerase.': [2872], 'Unincorporated': [2873], 'removed': [2876], 'polyacrylamide': [2878], 'electrophoresis.': [2880], 'Binding': [2881], 'performed': [2883, 4341], '30': [2885, 2947, 3101, 3665], 'nuclear': [2894], 'ng': [2899], 'labeled': [2901], 'probe': [2903], 'total': [2908], 'volume': [2909], '0.125': [2911], 'poly(dI-dC),': [2914], '12': [2915], 'HEPES-KOH,': [2917], '7.9,': [2919], 'KCl,': [2922], '1.0': [2923, 2979], '0.3': [2926], 'dithiothreitol,': [2928], '12%': [2929], 'glycerol,': [2930], 'inhibitors.': [2933], 'supershift': [2935], 'experiments,': [2936], 'SRF': [2940, 3074, 3103], 'prior': [2949], 'radiolabeled': [2954], 'probe.': [2955], 'Protein-DNA': [2956], 'complexes': [2957], 'resolved': [2959], 'cm,': [2963], 'acrylamide': [2965], '(29:1': [2967], 'acrylamide:bisacrylamide;': [2968], 'Fisher)': [2969], 'mAmp/gel': [2972], '1×': [2974], 'TGE': [2975], 'Tris,': [2978], '190': [2982], 'glycine,': [2984], '8.0)': [2986], '3': [2988], 'gels': [2991], 'Immunofluorescence—VSMC': [2996], '18-mm': [3000], 'glass': [3001], 'coverslips,': [3002], 'before': [3003], 'being': [3004], 'Stimulated': [3020], '(myr-Akt2': [3028], 'myr-Akt9),': [3030], 'along': [3031, 3812], 'fixed': [3038], '3.7%': [3040], 'formaldehyde': [3041], 'temperature.': [3049], 'permeabilized': [3055], 'PBS.': [3069], 'Prior': [3070], '(Santa': [3076], 'Cruz)': [3077], 'detected': [3106, 3226], 'an': [3108, 3383, 3525, 3591, 3642, 3893], 'anti-rabbit': [3109], 'coupled': [3111, 4327], 'Texas': [3113], 'Red': [3114], '(Molecular': [3115, 3134], 'Probes).': [3116], 'After': [3117], 'labeling,': [3121], 'ALEXA': [3130], 'Fluor': [3131], '488': [3132], 'Phalloidine': [3133], 'Probes)': [3135], 'detection': [3145], 'F-actin.': [3147], 'coverslips': [3149], 'mounted': [3151], 'VectaShield': [3153], '4′-6-diamino-2-phenylindole': [3156], '(DAPI)': [3157], '(Vector': [3158], 'laboratories),': [3159], 'Zeiss': [3167], 'Axiovert': [3168], 'inverted': [3169], 'fluorescence': [3170], 'microscope.': [3171], 'Selectively': [3173], 'Activates': [3174], 'VSMC—The': [3179], 'stimulate': [3186, 3576], 'determined': [3189, 3389, 3774, 4171], 'following': [3200, 4174], 'agonist': [3201], 'stimulation,': [3202], 'phospho-specific': [3205], 'antibody,': [3207], 'detects': [3209], 'serine': [3212], '473.': [3213], 'rapidly': [3215], 'increased': [3216, 4016, 4141, 4185], 'Maximal': [3222], '(∼6-fold)': [3224], '5–30': [3228], 'up': [3234], 'no': [3239, 3600], 'significant': [3240, 3601], 'decrease': [3241], '(Fig.': [3242, 3266, 3317, 3338, 3437, 3571, 3611, 3669, 3767, 3797, 3829, 3976, 4046, 4145, 4196, 4287], '1A).': [3243], 'exposure': [3246, 3758, 3788, 4175], 'resulted': [3251, 4159], 'very': [3254], 'modest': [3255, 3310, 4097], 'increase': [3256, 3300, 3311, 3657, 4244, 4272], 'phospho-Akt': [3258, 3427, 4124], '(<2-fold),': [3259], 'nature': [3265], '1A),': [3267], 'returned': [3269], 'levels': [3272, 3428, 4122, 4229], 'confirmed': [3280, 4057], 'directly': [3282, 3461], 'anti-Akt': [3289], 'antibodies,': [3290], 'substrate.': [3295], 'gave': [3297], '∼10-fold,': [3304], 'seen': [3313], '1B).': [3318], 'Treatment': [3319], 'inhibitor,': [3329], 'greater': [3335], 'than': [3336], '80%': [3337], '1C),': [3339], 'indicating': [3340], 'workers': [3355], '(28Jung': [3356], 'Haendeler': [3358], 'Goebel': [3360], 'Zeiher': [3362], 'A.M.': [3363], 'Dimmeler': [3364], 'Cardiovasc.': [3366], '48:': [3369], '148-157Crossref': [3370], '(89)': [3373], 'To': [3376, 3509, 3631], 'test': [3377], 'upstream': [3384], 'activator': [3385], 'H-Ras': [3396], 'independent': [3424], 'clones,': [3425], 'significantly': [3431, 4140], 'elevated': [3432], 'compared': [3433, 4125], '1D),': [3438], 'still': [3445, 3564], 'able': [3446], 'Akt.': [3449, 4078], 'does': [3467, 4420], 'require': [3469], 'Ras.': [3470], 'regulated': [3476, 3838], 'consists': [3481, 3616], 'heterodimer': [3484], 'regulatory': [3487, 3623], '85-kDa': [3488], 'catalytic': [3491, 3530, 3628], '110-kDa': [3492], 'subunit': [3493, 3531, 3624, 3629], 'form,': [3515, 3636], 'p110α': [3529, 3552, 3581, 3810], 'measured': [3538], 'immunoprecipitates': [3541], '(see': [3542, 4067], '"Materials': [3543, 4068], 'Methods").': [3545, 4070], 'formation': [3547, 3579], 'apparent': [3554], '2A).': [3572], 'did': [3574], 'any': [3583], 'points': [3585], 'tested.': [3588], 'Immunoprecipitation': [3589], 'p110β': [3594], 'constitutive': [3596, 3953, 4151], '2B).': [3612], 'dimer': [3619], '101-kDa': [3622], 'p110γ': [3627], '(p101/p110γ).': [3630], 'assess': [3632, 3865], 'p101.': [3645], 'Stimulation': [3646, 4370], 'observed': [3663, 4203], '2C).': [3670], 'Thus,': [3671], 'although': [3672], 'active': [3679], 'selectivity': [3683], 'kinetics': [3690], 'suggest': [3693], 'Mediates': [3709, 3859], 'Suppression': [3710, 3860], 'SM-α-Actin': [3712], 'Expression—To': [3713, 3864], 'establish': [3714], 'expression,': [3724, 3884], 'activity.': [3742, 4298], 'Consistent': [3743, 4260], 'earlier': [3746], 'studies,': [3747], '3A).': [3768], 'Changes': [3769], 'antibody.': [3781], 'decreased': [3783], 'almost': [3792], 'completely': [3793], 'inhibition': [3796], '3B).': [3798], 'Conversely,': [3799], 'co-transfected': [3803], 'gain-of-function,': [3806], 'form': [3808, 3895], '(myr-p110α),': [3811], '3C),': [3830], 'implicating': [3831], 'suppressive': [3836], 'further': [3847, 4104, 4162], 'suggesting': [3852], 'involvement': [3854], 'additional': [3856], 'pathways.': [3857], 'c-Src': [3901], 'fused': [3905], 'c-Akt': [3912], 'association': [3943], 'activation.': [3954], 'Co-transfection': [3955], 'had': [3962, 4109, 4227, 4236], 'markedly': [3970], '4A).': [3977], '505-bp': [3991], '(29Li': [3997], 'Cserjesi': [4001], '1996;': [4007], '78:': [4008], '188-195Crossref': [4009], '(352)': [4012], '4–6-fold,': [4020], 'similar': [4039, 4198], 'extent': [4040], '4B).': [4047], 'stable': [4059, 4291], 'retroviral-mediated': [4064], 'transfer': [4066], 'G418-resistant': [4071], 'nine': [4080], 'screened,': [4082], 'one': [4083], 'clone': [4084], 'showing': [4085, 4095], 'highest': [4087, 4238], 'level': [4088], '(Clone': [4091, 4099, 4314], '9)': [4092, 4306], '2)': [4100], 'characterization.': [4105], 'All': [4106], 'normal': [4110], 'morphology': [4111], 'contrast': [4114], '(data': [4115], 'shown).': [4117], 'myr-Akt9': [4118], 'constitutively': [4120], 'high': [4121], '(Neo': [4133], 'Control': [4134], '10),': [4135], '5A).': [4146], 'Clone': [4147, 4224, 4233, 4356], 'phospho-Akt,': [4155], 'Levels': [4164], 'Neo': [4182], 'controls,': [4183], '5B),': [4197], 'what': [4200], 'wild-type': [4205], 'cells.': [4206], 'myr-Akt,': [4211, 4269], 'decreased.': [4218], 'blunted': [4222], '2,': [4225], 'moderate': [4228], 'overexpression.': [4231], '9,': [4234], 'levels,': [4240], 'failed': [4242], 'some': [4249], 'experiments': [4250, 4340], 'clones.': [4259], 'co-transfections': [4267], 'AVP-mediated': [4271, 4369], '6).Fig.': [4288], '6Effects': [4289], '(Clones': [4303], '10)': [4315], '(A)': [4322], '(B)': [4326], 'reporter.': [4330], 'represent': [4333], 'means': [4335], '±': [4336], 'S.E.': [4337], 'duplicate.': [4343], '*,': [4344], 'p': [4345, 4351], '<': [4346, 4352], '0.05': [4347, 4353], 'versus': [4348, 4354], 'basal;': [4349], '#,': [4350], 'LNCX': [4355], '10.View': [4357], 'Large': [4358], 'Image': [4359], 'Figure': [4360], 'ViewerDownload': [4361], 'Hi-res': [4362], 'image': [4363], 'Download': [4364], '(PPT)': [4365], 'Inhibits': [4368], 'JNK': [4372, 4402], 'Kinases—We': [4376], 'sought': [4377], 'identify': [4379], 'effectors': [4382], 'activation,': [4385], 'mediate': [4387], 'Previous': [4393], 'ERK': [4419], 'play': [4422], 'major': [4424]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031692128', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-31T00:34:35.131398', 'created_date': '2016-06-24'}