Vascular Endothelial Growth Factor Up-regulates ICAM-1 Expression via the Phosphatidylinositol 3 OH-kinase/AKT/Nitric Oxide Pathway and Modulates Migration of Brain Microvascular Endothelial Cells

Name: Work Video:
Duration: 3 min 30 s
Zivotije Radisavljevic; Hava Avraham; Shalom Avraham
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2479, 2492, 2514, 2541, 2552, 2590, 2625, 2636, 2648, 2671, 2686, 2693, 2701, 2720, 2745, 2757, 2766, 2784, 2794, 2852, 2888, 2892, 2897, 2903, 2911, 2947, 2957, 2972, 3014, 3067, 3139, 3147, 3152, 3163, 3190, 3214, 3217, 3427, 3462, 3482, 3533, 3567, 3591, 3597, 3626, 3792, 3842, 3915, 4156, 4185, 4195, 4263, 4403, 4409, 4413, 4424, 4499, 4509, 4622, 4627, 4637, 4643, 4649, 4687], 'cerebral': [3, 275, 1872], 'blood': [4, 276, 948, 977, 1899], 'microvessels,': [5, 277, 3069], 'which': [6, 137, 161, 233, 278, 409, 433, 505, 1036, 1339, 1594, 2545, 2920, 3468, 3585, 4228], 'constitutes': [7, 279], 'major': [9, 281, 1608], 'component': [10, 282, 1609, 2996], 'blood-brain': [13, 262, 285, 534, 544], 'barrier,': [14, 263, 286, 535], 'controls': [15, 287], 'leukocyte': [16, 288], 'and': [17, 22, 73, 99, 101, 127, 155, 170, 208, 221, 252, 289, 294, 345, 371, 373, 399, 427, 442, 480, 493, 524, 607, 671, 704, 783, 871, 956, 1001, 1008, 1078, 1121, 1137, 1189, 1259, 1263, 1284, 1495, 1527, 1575, 1631, 1639, 1737, 1798, 1805, 1820, 1861, 1881, 1894, 1916, 1941, 2025, 2033, 2156, 2236, 2265, 2313, 2321, 2381, 2415, 2433, 2466, 2483, 2527, 2534, 2556, 2570, 2573, 2600, 2652, 2732, 2747, 2773, 2790, 2851, 2915, 2971, 2990, 3026, 3075, 3108, 3141, 3146, 3185, 3187, 3207, 3247, 3314, 3464, 3538, 3557, 3561, 3590, 3643, 3748, 3781, 3882, 3896, 3944, 4051, 4099, 4191, 4222, 4261, 4320, 4422, 4482, 4488, 4516, 4617, 4647, 4658, 4690], 'metastatic': [18, 290], 'cancer': [19, 291, 705, 1289, 3312], 'cell': [20, 239, 292, 511, 613, 625, 781, 999, 1290, 2044, 2929, 3245, 3647], 'adhesion': [21, 59, 293, 331, 557, 1531], 'trafficking': [23, 295], 'into': [24, 296, 1366, 1448, 1590, 1741, 1818, 3540, 3596, 4636], 'brain': [26, 34, 236, 270, 298, 306, 508, 542, 552, 679, 709, 1305, 1344, 1368, 3068, 3598], 'parenchyma.': [27, 299], 'In': [28, 123, 300, 395, 1025, 2478, 2925, 3000, 3419, 3525, 4011], 'this': [29, 301, 674, 2577, 2595, 2776, 3001, 3526, 3563, 4640, 4670, 4695], 'study,': [30, 302, 3002, 3527, 4013, 4671], 'using': [31, 303, 1707, 1732, 1794, 1989, 2052, 2429, 2793], 'rat': [32, 304, 1871, 3127], 'primary': [33, 305, 2295, 2682, 2752, 3128], 'microvascular': [35, 307, 553, 614], 'endothelial': [36, 44, 238, 308, 316, 510, 547, 554, 578, 601, 612, 780, 963, 998, 1398, 1939, 2043, 2928, 3064, 3227, 3233, 3244, 3633, 3641, 3801, 3848, 3899, 4063, 4220, 4520], 'cells': [37, 309, 555, 964, 1029, 1730, 1900, 2011, 2088, 2398, 3065, 3642, 3802, 3849, 3895, 4064, 4221, 4515, 4521], '(BMEC),': [38, 310], 'we': [39, 311, 2550, 2634, 2680, 2782, 3003, 3130, 3528, 3545, 4014], 'demonstrate': [40, 212, 312, 484, 2531, 2984, 3546, 4018, 4089], 'that': [41, 66, 213, 313, 338, 485, 745, 1522, 2532, 2563, 2574, 2612, 2644, 2825, 2834, 2985, 2991, 3006, 3132, 3531, 3547, 3562, 4019, 4090, 4178, 4192, 4278, 4505], 'vascular': [43, 315, 546, 1191, 3892], 'growth': [45, 317, 548, 870], 'factor': [46, 216, 318, 488, 549, 744, 909], '(VEGF),': [47, 319], 'a': [48, 63, 90, 202, 246, 320, 335, 362, 474, 518, 741, 907, 1298, 1328, 1401, 1607, 1618, 1795, 1803, 1906, 2101, 2108, 2150, 2691, 3095, 3100, 3238, 3435, 3622, 3877, 4022, 4201, 4284, 4612], 'potent': [49, 321, 742, 3239, 3623, 3878, 4023], 'promoter': [50, 322], 'angiogenesis,': [52, 324, 3305], 'up-regulates': [53, 218, 325, 490, 2547, 4485], 'expression': [55, 134, 169, 220, 327, 406, 441, 492, 1440, 2032, 2468, 2488, 2508, 2518, 2591, 2616, 3008, 3145, 3556, 3636, 4487], 'intracellular': [58, 330, 556, 1132, 1140, 1173, 3941, 4317], 'molecule-1': [60, 332, 558], '(ICAM-1)': [61, 333], 'through': [62, 229, 334, 501, 1393, 1397, 3151, 3481, 4283, 4324, 4621], 'novel': [64, 336], 'pathway': [65, 337, 1403, 1569, 2543, 3154, 3199, 3437, 3569, 4158, 4405, 4624, 4641], 'includes': [67, 339], 'phosphatidylinositol': [68, 340, 560], '3': [69, 341, 561, 2460], 'OH-kinase': [70, 342, 562], '(PI3K),': [71, 343], 'AKT,': [72, 344, 3536], 'nitric': [74, 346, 563], 'oxide': [75, 347, 564], '(NO),': [76, 348], 'resulting': [77, 349, 3188, 4625], 'in': [78, 89, 121, 350, 361, 393, 585, 673, 868, 1112, 1131, 1172, 1186, 1331, 1441, 1459, 1496, 1537, 1544, 1565, 1703, 1905, 1922, 2096, 2100, 2152, 2176, 2195, 2216, 2222, 2260, 2283, 2378, 2386, 2402, 2513, 2629, 2675, 2678, 2751, 2761, 2828, 2860, 2870, 2887, 3138, 3155, 3189, 3200, 3225, 3432, 3461, 3476, 3559, 3574, 3582, 3791, 3850, 3914, 3940, 4028, 4039, 4044, 4047, 4056, 4059, 4096, 4100, 4155, 4189, 4204, 4219, 4316, 4458, 4496, 4513, 4619, 4626, 4642, 4648, 4666, 4676], 'migration': [80, 352, 784, 1002, 1392, 1445, 1546, 1582, 2045, 2772, 2777, 2785, 2795, 2878, 2930, 2989, 3020, 3150, 3208, 3248, 3301, 3463, 3480, 3558, 3593, 3843, 4102, 4618], 'BMEC.': [82, 122, 354, 394, 1538, 1584, 2753, 3156], 'Upon': [83, 355, 1097, 3169], 'VEGF': [84, 126, 154, 217, 356, 398, 426, 489, 739, 904, 1012, 1034, 1071, 1101, 1185, 1249, 1526, 1543, 1567, 1595, 2116, 2385, 2448, 2456, 2462, 2482, 2533, 2546, 2555, 2599, 2618, 2630, 2651, 2769, 2789, 2835, 2855, 2875, 2933, 2986, 3133, 3236, 3421, 3456, 3548, 3805, 3875, 3919, 4020, 4040, 4097, 4461, 4615], 'treatment,': [85, 357], 'AKT': [86, 93, 103, 358, 365, 375, 1637, 1641, 1720, 1780, 1800, 1986, 2031, 2034, 2517, 2559, 2564, 2580, 2584, 2655, 2665, 2674, 2698, 2748, 2760, 3164, 3175, 4038, 4154, 4180, 4226, 4255, 4410, 4453, 4506], 'is': [87, 266, 359, 538, 583, 665, 740, 918, 1108, 1369, 2619, 2778, 2993, 3009, 3092, 3176, 3202, 3237, 3302, 3629, 3649, 3838, 3876, 3907, 4021, 4035, 4223, 4273], 'phosphorylated': [88, 360, 1640, 2567, 3177, 4179], 'PI3K-dependent': [91, 363, 4285], 'manner.': [92, 364], 'activation': [94, 366, 1114, 1266, 3573, 4216, 4425], 'leads': [95, 234, 367, 506, 3586, 4229], 'to': [96, 223, 235, 245, 368, 495, 507, 517, 628, 678, 707, 1102, 1129, 1179, 1292, 1295, 1303, 1342, 1559, 1576, 1859, 2268, 2328, 2459, 2632, 2830, 3018, 3181, 3425, 3553, 3579, 3587, 3775, 3787, 3795, 3852, 3909, 4017, 4150, 4230, 4266, 4275, 4460], 'NO': [97, 105, 119, 130, 156, 196, 369, 377, 391, 402, 428, 468, 747, 1262, 1574, 1701, 2040, 2342, 2535, 2557, 2575, 2601, 2653, 2676, 2715, 2728, 2762, 2840, 2857, 3183, 3550, 3881, 3886, 3942, 4026, 4034, 4091, 4188, 4205, 4232, 4267, 4280, 4331, 4483, 4512], 'production': [98, 106, 370, 378, 1572, 1702, 2713, 2729, 3184, 4027, 4186, 4206, 4233, 4510], 'release': [100, 120, 372, 392, 1260, 3551, 4281, 4332], 'activation-deficient': [102, 374], 'attenuates': [104, 376, 4419], 'stimulated': [107, 379, 2201, 2383, 2454], 'by': [108, 140, 148, 164, 184, 186, 191, 201, 380, 412, 420, 436, 456, 458, 463, 473, 1011, 1372, 1525, 1593, 1731, 1793, 1835, 1864, 1875, 1883, 1913, 1997, 2027, 2048, 2168, 2182, 2384, 2473, 2491, 2544, 2617, 2742, 2910, 2932, 2944, 2968, 3011, 3071, 3094, 3167, 3223, 3804], 'VEGF.': [109, 381, 2831, 3168], 'Transfection': [110, 382], 'constitutive': [113, 385], 'myr-AKT': [114, 386, 577, 2723], 'construct': [115, 387, 2710, 4199], 'significantly': [116, 157, 388, 429, 2711, 2842, 2880, 2937], 'increased': [117, 158, 389, 430, 2712, 2843, 2927, 3182, 4231], 'basal': [118, 390, 608, 3076], 'these': [124, 396, 623, 3583], 'cells,': [125, 397, 602, 3234, 3584, 3900], 'endothelium-derived': [129, 401], 'synergistically': [131, 403], 'up-regulated': [132, 404, 3010], 'ICAM-1,': [136, 408, 2633, 2781, 3621], 'was': [138, 146, 162, 171, 182, 410, 418, 434, 443, 454, 1558, 1617, 1628, 1633, 1722, 1738, 1787, 1816, 1833, 1862, 2046, 2325, 2344, 2422, 2436, 2471, 2489, 2522, 2565, 2737, 2879, 2936, 4148], 'mediated': [139, 163, 411, 435, 1370, 1524, 2620, 2779], 'PI3K': [142, 414, 2120, 2628, 2893, 3158, 3179, 3836], 'pathway.': [143, 179, 415, 451, 3543], 'This': [144, 180, 416, 452, 1110, 3195, 3904], 'activity': [145, 417, 1195, 1499, 3837], 'blocked': [147, 419, 2943, 3162], 'PI3K-specific': [150, 422, 2637], 'inhibitor,': [151, 423, 2638, 3159], 'wortmannin.': [152, 424], 'Furthermore,': [153, 425, 1539], 'BMEC': [159, 250, 431, 522, 1326, 1394, 1442, 1545, 1600, 1704, 1867, 1910, 1919, 1946, 1977, 2186, 2237, 2452, 2683, 2771, 2787, 2826, 2849, 2877, 2988, 2998, 3019, 3172, 3201, 3205, 3472, 3560, 3575, 4029, 4048, 4101, 4190, 4457, 4491, 4646, 4677], 'migration,': [160, 432, 2850], 'up-regulation': [166, 438, 2613, 3142, 3191, 4628], 'ICAM-1': [168, 189, 206, 219, 224, 440, 461, 478, 491, 496, 1373, 1399, 1439, 1455, 1502, 1564, 1650, 1660, 1667, 2132, 2450, 2464, 2470, 2487, 2507, 2537, 2548, 2593, 2615, 2899, 2917, 2923, 2949, 2974, 2992, 3007, 3144, 3193, 3485, 3539, 3555, 3572, 3638, 4486], 'dependent': [172, 444, 4224], 'on': [173, 445, 1530, 1580, 1599, 2449, 2506, 2558, 2654, 2664, 2770, 2876, 3631, 3639, 3644, 4184, 4225, 4258, 4330, 4412, 4450], 'integrity': [175, 265, 447, 537, 3215], 'PI3K/AKT/NO': [178, 231, 450, 503, 3015, 3153, 3568, 4623], 'effect': [181, 453, 1579, 2446, 2505, 2663, 2767, 2873, 3469, 3917, 4183, 4329], 'abolished': [183, 455, 2647], 'wortmannin,': [185, 205, 457, 477, 3160], 'specific': [188, 193, 460, 465, 2904, 2958], 'antibody,': [190, 207, 462, 479], 'inhibitor': [194, 466, 2121, 2894, 2906, 2960], 'synthase,N': [197, 469], 'G-l-monomethyl-arginine': [198, 470, 566, 1626], '(l-NMMA)': [199, 471, 1627], 'or': [200, 472, 634, 867, 970, 2212, 2700, 2909, 2967, 4406], 'combination': [203, 475, 2853, 2912], 'l-NMMA.': [209, 481], 'These': [210, 241, 482, 513, 1585, 2529, 2609, 2754, 2982, 4493, 4631], 'findings': [211, 483, 3220, 3530, 4500], 'angiogenic': [215, 487, 743, 1498], 'signals': [222, 494, 3581], 'as': [225, 255, 257, 497, 527, 529, 777, 779, 906, 1075, 1601, 1603, 1606, 1656, 1658, 1809, 2014, 2036, 2038, 2061, 2125, 2127, 2346, 2690, 2740, 2797, 2837, 2839, 3209, 3211, 3230, 3937, 3939, 4042, 4053, 4055], 'an': [226, 498, 1783, 1799, 2015, 2861, 2994, 3135, 3458, 3911, 4093, 4182], 'effector': [227, 499], 'molecule': [228, 500], 'pathway,': [232, 504, 3016], 'microvessel': [237, 509], 'migration.': [240, 512, 2871, 2999, 4492], 'observations': [242, 514], 'may': [243, 515, 676], 'contribute': [244, 516], 'better': [247, 519], 'understanding': [248, 520], 'angiogenesis': [251, 523, 969, 1007, 1040, 1188, 1465], 'physiological': [254, 526], 'well': [256, 528, 778, 1602, 1657, 1810, 2037, 2126, 2838, 3210, 3938, 4054], 'pathophysiological': [258, 530], 'function': [259, 531, 639, 1605, 3206, 4644], 'whose': [264, 536], 'crucial': [267, 539, 3303, 3789], 'for': [268, 540, 631, 667, 910, 921, 1006, 1070, 1653, 1662, 2030, 2039, 2137, 2159, 2189, 2297, 2309, 2372, 2392, 2408, 2457, 3024, 3204, 3212, 3304, 3841, 4614, 4662, 4669, 4674, 4682, 4686, 4693], 'normal': [269, 541, 669], 'function.': [271, 543, 2924], 'barrier': [545, 618], 'nitric-oxide': [550, 579, 1176], 'synthase': [551, 580, 1177], 'hemagglutinin': [559], 'N': [565], 'fetal': [567, 1928], 'bovine': [568, 1885, 1929, 2093, 3231, 3242, 3897], 'serum': [569, 1886, 1904, 1930, 2094], 'phosphate-buffered': [570], 'saline': [571], 'full-length': [572, 1719, 2694], 'AKT-cDNA': [573, 2695], 'pLNCX-HA-myr-AKT': [574, 2702], 'mutant': [575, 1831, 2697, 2721, 4270], 'dominant-negative': [576, 2722], 'The': [581, 596, 660, 1066, 1170, 1182, 1519, 1613, 1698, 1718, 1813, 1828, 1854, 2341, 2411, 2705, 2872, 3056, 3090, 3157, 3635, 3778, 4210], 'BBB1': [582], 'involved': [584, 3475], 'maintenance': [587, 635, 923, 4650], 'microenvironment': [590], 'central': [593], 'nervous': [594], 'system.': [595], 'BBB': [597, 642, 664, 1255, 3057, 3091, 3470, 3483, 4652], 'system': [598], 'consists': [599, 3058], 'pericytes,': [603, 3073], 'perivascular': [604], 'microglia,': [605, 3074], 'astrocytes,': [606, 3072], 'lamina.': [609], 'Whereas': [610], 'monolayer': [615], 'forms': [616], 'proper,': [619], 'interaction': [621], 'between': [622], 'various': [624, 3645], 'types': [626, 3648], 'seems': [627], 'be': [629, 3776, 3788, 4151], 'necessary': [630, 3840], 'induction': [633], 'specialized': [638], '(1.Risau': [643, 3920], 'W.': [644, 1216, 3669, 3734, 3921], 'Wolburg': [645, 3922], 'H.': [646, 750, 1143, 1758, 3029, 3923, 4576], 'Trends': [647, 3924], 'Neurosci.': [648, 3925], '1990;': [649, 1687, 3926], '13:': [650, 3927, 4168], '174-178Abstract': [651, 3928], 'Full': [652, 767, 769, 797, 799, 1160, 1162, 1472, 1690, 1765, 1767, 1971, 3046, 3048, 3290, 3292, 3519, 3615, 3740, 3826, 3828, 3929, 4115, 4117, 4137, 4139, 4472, 4474, 4597, 4599], 'Text': [653, 768, 770, 798, 800, 1161, 1163, 1473, 1691, 1766, 1768, 1972, 3047, 3049, 3291, 3293, 3520, 3616, 3741, 3827, 3829, 3930, 4116, 4118, 4138, 4140, 4473, 4475, 4598, 4600], 'PDF': [654, 771, 801, 1164, 1474, 1692, 1769, 1973, 3050, 3294, 3521, 3617, 3742, 3830, 3931, 4119, 4141, 4476, 4601], 'PubMed': [655, 699, 734, 772, 802, 835, 862, 887, 899, 941, 992, 1020, 1061, 1092, 1165, 1204, 1225, 1244, 1279, 1321, 1475, 1488, 1693, 1770, 1849, 1974, 2082, 2818, 3051, 3085, 3121, 3273, 3295, 3341, 3368, 3387, 3399, 3414, 3450, 3522, 3618, 3679, 3743, 3831, 3870, 3932, 3981, 4006, 4081, 4120, 4142, 4170, 4250, 4309, 4343, 4358, 4376, 4396, 4444, 4477, 4538, 4564, 4602], 'Scopus': [656, 700, 735, 773, 803, 836, 863, 888, 900, 942, 993, 1021, 1062, 1093, 1166, 1245, 1322, 1476, 1489, 1694, 1771, 1850, 2083, 2365, 2819, 3052, 3086, 3122, 3274, 3296, 3342, 3369, 3388, 3400, 3415, 3451, 3680, 3744, 3832, 3871, 3933, 3962, 3982, 4007, 4082, 4121, 4143, 4171, 4251, 4310, 4344, 4377, 4397, 4445, 4478, 4539, 4565, 4603], '(416)': [657, 3934], 'Google': [658, 702, 737, 775, 805, 838, 865, 890, 902, 944, 995, 1023, 1064, 1095, 1168, 1205, 1226, 1247, 1280, 1324, 1362, 1389, 1419, 1437, 1478, 1491, 1517, 1696, 1773, 1852, 1975, 2085, 2367, 2821, 3054, 3088, 3124, 3276, 3298, 3344, 3371, 3390, 3402, 3417, 3453, 3501, 3523, 3619, 3682, 3711, 3729, 3746, 3767, 3834, 3873, 3935, 3964, 3984, 4009, 4084, 4123, 4145, 4173, 4253, 4312, 4346, 4359, 4379, 4399, 4447, 4480, 4541, 4567, 4605], 'Scholar).': [659, 738, 806, 903, 945, 996, 1024, 1065, 1096, 1169, 1248, 1281, 1325, 1363, 1390, 1438, 1518, 1697, 1774, 1853, 1976, 2086, 2368, 2822, 3055, 3089, 3125, 3299, 3418, 3454, 3524, 3620, 3835, 3874, 4010, 4085, 4146, 4174, 4254, 4313, 4400, 4448, 4606], 'permeability': [661, 675, 1192, 1252, 3111, 3428, 3465], 'important': [666, 2995, 3136, 3203, 3459, 3912, 4094], 'its': [668, 1103, 1105, 1578, 1597, 1604, 3770], 'functioning,': [670], 'changes': [672, 3589], 'lead': [677], 'infection': [680], '(2.Komatsu': [681, 2064, 2800], 'T.': [682, 813, 819, 983, 1048, 1083, 1467, 2065, 2801, 3319, 3325, 3405, 3441], 'Ireland': [683, 2066, 2802], 'D.D.': [684, 849, 2067, 2803, 3355], 'Chung': [685, 2068, 2804], 'N.': [686, 1750, 1958, 2069, 2805, 3506, 3602, 3663, 3819], 'Dore': [687, 2070, 2806], 'A.': [688, 823, 883, 937, 1752, 2071, 2807, 3329, 3383, 3689, 3697, 3809, 4002, 4162, 4302, 4557], 'Yoder': [689, 2072, 2808], 'M.': [690, 725, 851, 1210, 1212, 1307, 1356, 2073, 2352, 2809, 3264, 3357, 3657, 3691, 3813, 3949, 3969, 3971, 4364, 4366], 'Shoshkes': [691, 2074, 2810], 'Reiss': [692, 2075, 2811], 'C.': [693, 2076, 2812, 3659, 4072, 4241, 4386, 4435, 4529], 'Nitric': [694, 2077, 2813], 'Oxide.': [695, 2078, 2814], '1999;': [696, 764, 794, 832, 989, 1089, 1157, 1201, 1222, 1276, 1386, 1416, 1514, 1762, 2079, 2815, 3043, 3287, 3338, 3411, 3447, 3498, 3708, 3726, 3867, 4078, 4112, 4134, 4167, 4247, 4306, 4441, 4469, 4535, 4561, 4594], '3:': [697, 2080, 2816], '327-339Crossref': [698, 2081, 2817], '(19)': [701, 2084, 2820], 'Scholar)': [703, 866], 'metastasis': [706, 872, 1336], '(3.Nicolson': [710, 3249], 'G.L.': [711, 3250, 4572], 'Menter': [712, 3251], 'D.G.': [713, 3252, 4584], 'Herrmann': [714, 3253], 'J.': [715, 721, 761, 791, 893, 1014, 1154, 1199, 1220, 1274, 1309, 1383, 1384, 1413, 1414, 1425, 1432, 1754, 1759, 1965, 2357, 3040, 3114, 3254, 3260, 3284, 3393, 3495, 3496, 3513, 3609, 3706, 3723, 3724, 3755, 3762, 3811, 3820, 3954, 3976, 4109, 4131, 4294, 4337, 4353, 4388, 4466, 4549, 4591], 'Cavanaugh': [716, 3255], 'P.': [717, 1375, 1405, 1423, 3256, 3487, 3715, 3753], 'Jia': [718, 3257], 'L.': [719, 3258, 3863], 'Hamada': [720, 3259], 'Yun': [722, 3261], 'Z.': [723, 2350, 3262, 3947, 3975], 'Nakajima': [724, 3263], 'Marchetti': [726, 3265], 'D.': [727, 1214, 1233, 1748, 3266, 3685, 4288, 4543, 4582], 'Crit.': [728, 3267], 'Rev.': [729, 1483, 1844, 3268], 'Oncog.': [730, 3269], '1994;': [731, 1968, 3270, 3516, 3612, 4355], '5:': [732, 3271], '451-471Crossref': [733, 3272], '(39)': [736, 3275], 'induces': [746, 3549, 4489], 'formation': [748, 974, 3887], '(4.He': [749, 1142], 'Venema': [751, 755, 1144, 1148, 3030, 3034], 'V.J.': [752, 1145, 3031], 'Gu': [753, 1146, 3032], 'X.': [754, 1147, 3033], 'R.C.': [756, 1149, 3035], 'Marrero': [757, 1150, 3036], 'M.B.': [758, 1151, 3037], 'Caldwell': [759, 1152, 3038], 'R.B.': [760, 1153, 3039], 'Biol.': [762, 792, 831, 988, 1155, 1760, 1966, 3041, 3285, 3337, 3410, 3514, 3610, 3821, 4110, 4132, 4467, 4592], 'Chem.': [763, 793, 1156, 1761, 1967, 3042, 3286, 3515, 3611, 3822, 4111, 4133, 4468, 4593], '274:': [765, 795, 1158, 1763, 3044, 3288, 4113, 4135, 4470, 4595], '25130-25135Abstract': [766, 1159, 3045], '(411)': [774, 1167, 3053], 'Scholar),': [776, 1492, 3712, 3747, 3768, 3936, 4481], 'proliferation': [782, 1000, 3246], '(5.Bernatchez': [785, 4103], 'P.N.': [786, 3279, 4104], 'Soker': [787, 3280, 4105], 'S.': [788, 882, 936, 1208, 1231, 1311, 1377, 1407, 1421, 1429, 1746, 1960, 3281, 3382, 3489, 3508, 3604, 3717, 3751, 3759, 4001, 4066, 4106, 4235, 4382, 4429, 4523], 'Sirois': [789, 3282, 4107], 'M.G.': [790, 3283, 4108], '31047-31054Abstract': [796, 3289, 4114], '(242)': [804, 3297, 4122], 'Angiogenesis': [807], 'occurs': [808, 950, 3565], 'after': [809], 'tissue': [810, 2224], 'ischemia': [811], '(6.Murohara': [812, 3318], 'Witzenbichler': [814, 3320], 'B.': [815, 821, 3321, 3327, 4070, 4239, 4384, 4433, 4527, 4570], 'Spyridopoulos': [816, 3322], 'I.': [817, 3323, 4068, 4237, 4368, 4431, 4525], 'Asahara': [818, 3324], 'Ding': [820, 3326, 4657], 'Sullivan': [822, 3328], 'Losordo': [824, 3330], 'D.W.': [825, 841, 3331, 3347], 'Isner': [826, 856, 3332, 3362], 'J.M.': [827, 857, 3333, 3363, 3989, 3991], 'Arterioscler.': [828, 3334], 'Thromb.': [829, 3335], 'Vasc.': [830, 3336], '19:': [833, 2363, 3339, 3960], '1156-1161Crossref': [834, 3340], '(271)': [837, 3343], 'Scholar,': [839, 891, 1206, 1227, 1479, 3277, 3345, 3372, 3391, 3403, 3502, 3683, 3730, 3965, 3985, 4124, 4347, 4360, 4380, 4568], '7.Losordo': [840, 3346], 'Vale': [842, 3348], 'P.R.': [843, 3349], 'Symes': [844, 3350], 'J.F.': [845, 3351], 'Dunnington': [846, 3352], 'C.H.': [847, 3353], 'Esakof': [848, 3354], 'Maysky': [850, 3356], 'Ashare': [852, 3358], 'A.B.': [853, 3359], 'Lathi': [854, 3360], 'K.': [855, 985, 1085, 1313, 3361, 3407, 3443, 3693, 3855, 4298, 4362, 4465, 4553], 'Circulation.': [858, 3364], '1998;': [859, 1241, 1434, 3365, 3764, 3823, 4393], '98:': [860, 3366, 4341], '2800-2804Crossref': [861, 3367], '(923)': [864, 3370], 'tumor': [869, 1285, 3310], '(8.Benjamin': [873, 927], 'L.E.': [874, 928, 3374], 'Keshet': [875, 929, 3375], 'E.': [876, 930, 1350, 3376, 3861], 'Proc.': [877, 931, 3377, 3996], 'Natl.': [878, 932, 3378, 3997], 'Acad.': [879, 933, 3379, 3998], 'Sci.': [880, 934, 3380, 3999], 'U.': [881, 935, 1235, 3381, 3703, 4000], '1997;': [884, 938, 3384], '94:': [885, 939, 3385], '8761-8766Crossref': [886, 940, 3386], '(444)': [889, 943, 3389], '9.Folkman': [892, 3392], 'Nat.': [894, 1015, 3394], 'Med.': [895, 1016, 3395], '1995;': [896, 1017, 3396, 3676, 3978], '1:': [897, 1018, 3397], '27-31Crossref': [898, 1019, 3398], '(7235)': [901, 1022, 3401], 'functions': [905], 'survival': [908, 3796, 4157], 'newly': [911, 3196], 'formed': [912], 'vessels': [913, 926, 949, 978, 981], 'during': [914, 2594, 3652], 'developmental': [915], 'neovascularization': [916, 971], 'but': [917], 'not': [919, 1534, 1548, 2726], 'required': [920], 'mature': [925], 'Formation': [946], 'via': [951, 1256, 1400, 2621, 2780, 3013, 3178, 3434, 3484, 3566, 4030], 'two': [952], 'distinct': [953], 'processes,': [954], 'vasculogenesis': [955], 'angiogenesis.': [957], 'Vasculogenesis': [958], 'involves': [959, 972, 1395], 'differentiation': [961], 'from': [965, 979, 1620, 1629, 1635, 1644, 1671, 1724, 1789, 1870, 1897], 'mesodermal': [966], 'precursors,': [967], 'whereas': [968, 2719, 4269], 'new': [976, 1588], 'pre-existing': [980], '(10.Veikkola': [982], 'Alitalo': [984, 1084, 3406, 3442], 'Semin.': [986, 3408], 'Cancer': [987, 1357, 1512, 3409], '9:': [990, 3412], '211-220Crossref': [991, 3413], '(451)': [994, 3416], 'Vascular': [997], 'are': [1003, 1009, 1523, 3221, 3473, 4495], 'critical': [1004], 'events': [1005], 'regulated': [1010], '(9.Folkman': [1013], 'brain,': [1027], 'glial': [1028], 'express': [1030], 'elevated': [1031], 'levels': [1032, 1133, 1452], 'protein,': [1035], 'correlate': [1037], 'with': [1038, 1464, 1901, 1926, 1952, 1980, 2056, 2091, 2115, 2128, 2143, 2149, 2162, 2192, 2202, 2233, 2240, 2256, 2279, 2287, 2294, 2315, 2318, 2375, 2389, 2405, 2424, 2438, 2455, 2598, 2606, 2684, 2856, 3173, 4498], 'hypoxia-derived': [1039], '(11.Ogunshola': [1041], 'O.O.': [1042], 'Stewart': [1043], 'W.B.': [1044], 'Mihalcik': [1045], 'V.': [1046, 1381, 1411, 3493, 3721, 3817], 'Solli': [1047], 'Madri': [1049], 'J.A.': [1050, 4351], 'Ment': [1051], 'L.R.': [1052], 'Brain': [1053, 1056, 1236, 1238, 2042, 3674], 'Res.': [1054, 1057, 1088, 1237, 1239, 1358, 1513, 3446, 3675, 3866, 4372, 4392], 'Dev.': [1055, 4166], '2000;': [1058], '119:': [1059], '139-153Crossref': [1060], '(226)': [1063], 'tyrosine-kinase': [1067], 'signaling': [1068, 1106, 1396, 1520, 1568, 2542, 2631, 3140, 3198, 3564, 4098, 4616], 'receptors': [1069], 'have': [1072, 1340, 1456, 1503, 1533, 3004, 3910, 4176, 4327], 'been': [1073, 1457, 1504, 1535, 1549, 3423, 3577], 'identified': [1074, 3197], 'Flt-1,': [1076], 'Flk-1/KDR,': [1077], 'Flt-4': [1079], '(12.Petrova': [1080, 3438], 'T.V.': [1081, 3439], 'Makinen': [1082, 3440], 'Exp.': [1086, 3080, 3444, 3864], 'Cell': [1087, 1316, 3300, 3445, 3865], '253:': [1090, 3448, 3868], '117-130Crossref': [1091, 3449], '(241)': [1094, 3452], 'binding': [1099], 'receptors,': [1104], 'cascade': [1107, 1120, 3906], 'activated.': [1109], 'results': [1111, 2530, 2610, 4494], 'mitogen-activated': [1117], 'protein': [1118, 4212, 4415], 'kinase': [1119, 1829, 4213], 'tyrosine': [1123], 'phosphorylation': [1124, 2035, 2578, 2656, 2666, 3165, 4421], 'phospholipase': [1126], 'Cγ1,': [1127], 'leading': [1128, 1294, 3017, 3180, 3552, 3794, 4265], 'increases': [1130, 1250, 4315], 'inositol': [1135], '1,4,5-trisphosphate': [1136], 'elevation': [1138], 'calcium': [1141, 1174], 'increase': [1171, 2864, 3426, 4203], 'activates': [1175, 3888, 4262], '(NOS)': [1178], 'produce': [1180], 'NO.': [1181], 'effects': [1183, 1529, 1598, 2553, 2649], 'stimulating': [1187], 'increasing': [1190], 'require': [1193], 'NOS': [1194, 2905, 2959, 4147], '(13.Mayhan': [1196, 1271], 'W.G.': [1197, 1272], 'Am.': [1198, 1219, 1273, 4352], 'Physiol.': [1200, 1221, 1275, 3081, 4354], '276:': [1202, 1223, 1277], 'C1148-C1153Crossref': [1203, 1278], '14.Fischer': [1207], 'Clauss': [1209], 'Wiesnet': [1211], 'Renz': [1213], 'Schaper': [1215], 'Karliczek': [1217], 'G.F.': [1218], 'C812-C820Crossref': [1224], '15.Weih': [1228], 'M.K.': [1229], 'Weikert': [1230], 'Freyer': [1232], 'Dirnagl': [1234, 3702], 'Protoc.': [1240], '2:': [1242], '175-182Crossref': [1243], '(8)': [1246], 'synthesis': [1258], 'subsequent': [1265], 'soluble': [1268, 1454, 1501], 'guanylate': [1269, 3889], 'cyclase': [1270, 3890], 'Cytokines': [1282], 'interleukin-1': [1283], 'necrosis': [1286], 'factor-α': [1287], 'regulate': [1288, 2536], 'adherence': [1291], 'BMEC,': [1293, 2679, 3129, 3467, 4620], 'metastases': [1296], 'number': [1299], 'human': [1301, 1461, 1615, 3798, 3845, 4060, 4517], 'cancers': [1302, 3749], '(16.Bereta': [1306], 'Bereta': [1308], 'Cohen': [1310, 1314], 'Zaifert': [1312], 'M.C.': [1315], 'Immunol.': [1317, 1385, 1415, 1433, 3497, 3707, 3725, 3735, 3763], '1991;': [1318], '136:': [1319], '263-277Crossref': [1320], '(34)': [1323], 'play': [1327], 'significant': [1329, 4202, 4490], 'role': [1330, 1541, 2672, 3137, 3460, 3913, 4095, 4613, 4638], 'determining': [1332], 'pattern': [1334], 'tumors': [1338], 'spread': [1341], '(17.Auerbach': [1345], 'R.': [1346, 3687, 4074, 4243, 4370, 4437, 4531, 4588], 'Lu': [1347], 'W.C.': [1348, 4304, 4559], 'Pardon': [1349], 'Gumkowski': [1351], 'F.': [1352, 4578], 'Kaminska': [1353], 'G.': [1354, 1511, 3701, 4334], 'Kaminski': [1355], '1987;': [1359, 1469, 1485, 1846], '47:': [1360], '1492-1496PubMed': [1361], 'Lymphocyte': [1364, 1391], 'extravasation': [1365], 'largely': [1371], '(18.Adamson': [1374, 1404, 3486, 3714], 'Etienne': [1376, 1406, 3488, 3716], 'Couraud': [1378, 1408, 1430, 1963, 3490, 3511, 3607, 3718, 3760], 'P.O.': [1379, 1409, 1431, 1964, 3491, 3512, 3608, 3719, 3761], 'Calder': [1380, 1410, 3492, 3720], 'Greenwood': [1382, 1412, 1424, 3494, 3722, 3754], '162:': [1387, 1417, 3499, 3727], '2964-2973PubMed': [1388, 1418, 3500, 3728], 'Rho-dependent': [1402], 'Scholar,19.Etienne': [1420], 'Adamson': [1422, 3752], 'Strosberg': [1426, 1961, 3509, 3605, 3756], 'A.D.': [1427, 1962, 3510, 3606, 3757], 'Cazaubon': [1428, 1959, 3507, 3603, 3758], '161:': [1435, 3765], '5755-5761PubMed': [1436, 3766], 'facilitates': [1443], 'leukocytes': [1447], 'brain.': [1450], 'Elevated': [1451], 'found': [1458, 2562, 2643, 2824], 'several': [1460], 'malignancies': [1462], 'associated': [1463], '(20.Hunter': [1466], 'Cell.': [1468, 1686], '50:': [1470], '823-829Abstract': [1471], '(774)': [1477], '21.Edelman': [1480], 'A.M.': [1481, 1842, 3673, 4076, 4245, 4390, 4439, 4533], 'Annu.': [1482, 1843], 'Biochem.': [1484, 1845], '56:': [1486, 1847], '567-613Crossref': [1487, 1848], '(1020)': [1490, 1851], 'andin': [1493], 'vitro': [1494], 'vivo': [1497], 'observed': [1505, 2490, 2523, 3131], '(22.Gho': [1506], 'Y.S.': [1507], 'Kleinman': [1508], 'H.K.': [1509], 'Sosne': [1510], '59:': [1515], '5128-5132PubMed': [1516], 'pathways': [1521], 'their': [1528, 4663], 'molecules': [1532], 'defined': [1536], 'has': [1547, 3422, 3576, 3773, 4092, 4181], 'elucidated.': [1550], 'Therefore,': [1551], 'goal': [1553], 'present': [1556, 3529, 3630], 'study': [1557, 4610], 'determine': [1560, 2774], 'involvement': [1562, 2626, 2758], 'underlying': [1570], 'VEGF-induced': [1571], 'examine': [1577], 'studies': [1586, 1665, 3224, 4046, 4058, 4632], 'provide': [1587, 4633], 'insights': [1589], 'mechanisms': [1592, 4326], 'mediates': [1596, 4215, 4454], 'BBB.': [1612, 3218], 'recombinant': [1614], 'VEGF165': [1616, 2203], 'gift': [1619], 'Genentech,': [1621], 'Inc.': [1622], 'l-Arginine': [1623, 2659], 'hydrochloride': [1624], 'crystalline,N': [1625], 'Sigma,': [1630], 'wortmannin': [1632, 2122, 2213, 2639, 2645, 2895, 2914, 2945, 2970], 'purchased': [1634, 1670], 'Calbiochem.': [1636], 'antibodies': [1638, 1642, 1652, 2296, 2303, 2950, 2975], 'were': [1643, 1669, 1705, 1868, 1911, 1920, 1947, 1978, 2012, 2023, 2089, 2135, 2147, 2180, 2187, 2199, 2230, 2238, 2292, 2307, 2370, 2399, 2413, 2453, 3785, 4015], 'New': [1645], 'England': [1646], 'Biolabs': [1647], '(Boston,': [1648], 'MA).': [1649], 'polyclonal': [1651], 'Western': [1654, 2028], 'blotting,': [1655], 'monoclonal': [1659, 2130, 2898, 2916, 2948, 2973], 'antibody': [1661, 2131, 2901, 2918], 'neutralization': [1664], 'function,': [1668], 'Santa': [1672], 'Cruz': [1673, 2305], 'Biotechnology': [1674], '(Santa': [1675, 2304], 'Cruz,': [1676], 'CA)': [1677], '(23.Staunton': [1678], 'D.E.': [1679], 'Dustin': [1680], 'M.L.': [1681], 'Erickson': [1682], 'H.P.': [1683, 3807], 'Springer': [1684], 'T.A.': [1685], '61:': [1688], '243-254Abstract': [1689], '(569)': [1695], 'measurements': [1699], 'performed': [1706, 2293, 2326, 2345, 2423, 2437], 'Nitrate/Nitrite': [1709], 'Colorimetric': [1710, 2426], 'Assay': [1711, 2427], 'kit': [1712, 2428], '(Cayman': [1713], 'Chemical,': [1714], 'Ann': [1715], 'Arbor,': [1716], 'MI).': [1717], 'cDNA': [1721, 1781, 1987, 2709, 2749], 'amplified': [1723, 1814], 'total': [1726], 'RNA': [1727], 'HeLa': [1729], 'reverse': [1733], 'transcriptase-polymerase': [1734], 'chain': [1735, 1837], 'reaction': [1736], 'then': [1739, 1895, 2157, 2200, 2266, 2322, 2382], 'subcloned': [1740], 'Bluescript': [1743, 1791], 'plasmid': [1744, 1792], '(24.Altiok': [1745], 'Batt': [1747], 'Altiok': [1749], 'Papautsky': [1751], 'Downward': [1753], 'Roberts': [1755], 'T.M.': [1756], 'Avraham': [1757], '32274-32278Abstract': [1764], '(104)': [1772], 'To': [1775, 2443, 2539, 2623, 2669, 2764], 'create': [1776], 'pLNCX-HA-AKT': [1778], 'construct,': [1779], 'lacking': [1782], 'ATG': [1784], 'start': [1785], 'codon': [1786], 'reamplified': [1788], 'T3': [1796], 'primer': [1797, 1801], 'containing': [1802], 'Kozak': [1804], 'HA': [1807], 'sequence': [1808], 'asBglII': [1811], 'site.': [1812], 'fragment': [1815], 'inserted': [1817], 'theClaI': [1819], 'BglII': [1821], 'sites': [1822], 'modified': [1825, 2049], 'pLNCX': [1826, 2687], 'plasmid.': [1827], 'active': [1830, 2707, 4197], 'HA-AKT-K179M': [1832], 'generated': [1834], 'polymerase': [1836], 'reaction-mediated': [1838], 'site-directed': [1839], 'mutagenesis': [1840, 1855], '(21.Edelman': [1841], 'converted': [1856], 'lysine': [1857], '179': [1858], 'methionine': [1860], 'confirmed': [1863, 2741], 'DNA': [1865], 'sequencing.': [1866], 'isolated': [1869], 'cortex': [1873], 'capillaries': [1874], 'enzymatic': [1876], 'digestion': [1877], 'at': [1878, 1888, 1949, 2107, 2140, 2568], '37': [1879, 1950, 2141], '°C': [1880, 1951, 2142], 'separated': [1882, 1896], '25%': [1884], 'albumin': [1887, 2095], '1000': [1889], '×': [1890, 2154], 'gfor': [1891], '15': [1892, 2569, 2586], 'min': [1893, 2161, 2498, 2572, 2587], 'red': [1898], '5%': [1902, 1932, 1953, 2144, 2280], 'horse': [1903, 1943], '50%': [1907], 'percoll': [1908], 'gradient.': [1909], 'purified': [1912], 'αThy': [1914], '1.1': [1915], 'rabbit': [1917], 'complement.': [1918], 'maintained': [1921], 'F-10': [1923, 2097, 2196, 2379], 'medium': [1924, 2380], 'supplemented': [1925], '4%': [1927, 2247], '(FBS),': [1931], 'penicillin/streptomycin,': [1933], '1%': [1934, 1936], 'glutamine,': [1935], 'heparin,': [1937], '0.7%': [1938], 'mitogen,': [1940], '15%': [1942], 'serum.': [1944], 'Primary': [1945, 2185], 'grown': [1948], 'CO2': [1954], '(25.Durieu-Trautmann': [1955, 3599], 'O.': [1956, 3504, 3600], 'Chaverot': [1957, 3505, 3601], '269:': [1969, 3517, 3613], '12536-12540Abstract': [1970, 3518, 3614], 'co-transfected': [1979], 'green': [1981, 2008], 'fluorescent': [1982, 2009], 'protein-pcDNA3': [1983], 'vector': [1984, 2688], 'plus': [1985, 2934], 'constructs': [1988, 2750], 'LipofectAMINE': [1991], 'method': [1992], 'following': [1993], 'protocol': [1995], 'provided': [1996], 'supplier': [1999], '(Life': [2000], 'Technologies,': [2001], 'Inc).': [2002], 'After': [2003, 2273, 2395], '24': [2004], 'h,': [2005], 'positive': [2007], 'protein-stained': [2010], 'corrected': [2013], 'indication': [2016], 'transfection': [2019, 2736, 4193], 'efficiency': [2020], '(∼55–60%).': [2021], 'Cells': [2022, 2134, 2179, 2198, 2229, 2369], 'harvested': [2024], 'analyzed': [2026, 2259, 2783], 'blotting': [2029], 'production.': [2041, 3885, 3903], 'evaluated': [2047], 'invasion': [2050], 'assay': [2051, 2343, 2796], 'transwells': [2053], '(Fisher)': [2054], 'coated': [2055], '2.5': [2057], 'μg/well': [2058], 'Matrigel,': [2060], 'described': [2062, 2347, 2798], 'previously': [2063, 2348, 2799], 'Endothelial': [2087], 'washed': [2090, 2232, 2314], '0.2%': [2092], 'medium,': [2098], 'prepared': [2099], 'concentration': [2102, 2109], '106': [2104], 'cells/ml,': [2105], 'plated': [2106], '105': [2111], 'cells/well,': [2112], 'and/or': [2113], 'treated': [2114, 2158], '(100': [2117, 2123, 2204, 2207, 2210, 2214, 2640], 'ng/ml),': [2118, 2205], 'nm),': [2124], '(1:25).': [2133], 'incubated': [2136, 2308, 2401], '18': [2138], 'h': [2139, 2191, 2299, 2311, 2374, 2475], 'CO2.': [2145], 'Transwells': [2146], 'swabbed': [2148], 'Q-tip': [2151], '1': [2153, 2253, 2310, 2500, 2604, 4050], 'PBS': [2155, 2286, 2317, 2388, 2404], '10': [2160], '600': [2163, 2169], 'μl': [2164, 2170], 'methanol': [2166], 'followed': [2167], '0.02%': [2172], 'Crystal': [2173], 'Violet': [2174], 'stain': [2175], '2%': [2177], 'ethanol.': [2178], 'counted': [2181], 'light': [2183], 'microscopy.': [2184], 'starved': [2188, 2371], '6': [2190, 2373, 3023], '0.1%': [2193, 2220, 2284, 2288, 2319, 2376, 2390, 2406], 'FBS': [2194, 2221, 2377, 2391, 2407], 'medium.': [2197], 'l-arginine': [2206, 2484, 2791, 2935], 'μm),': [2208, 2211], 'l-NMMA': [2209, 2907, 2961], 'nm)': [2215], 'presence': [2218, 2480, 2889], '60-mm': [2223], 'culture': [2225], 'dishes': [2226], '(Corning,': [2227], 'NY).': [2228], 'next': [2231], '1×': [2234, 2316, 2387, 2403], 'PBS,': [2235], 'lysed': [2239], 'SDS-sample': [2241], 'buffer': [2242], '(10': [2243], 'mmTris-HCl,': [2244], 'pH': [2245], '6.8,': [2246], 'SDS,': [2248], '20%': [2249], 'glycerol,': [2250], '0.4%': [2251], 'dithiothreitol,': [2252], 'mm': [2254], 'orthovanadate': [2255], 'bromphenol': [2257], 'blue),': [2258], '8%': [2261], 'SDS-polyacrylamide': [2262], 'gel': [2263], 'electrophoresis,': [2264], 'transferred': [2267], 'polyvinylidene': [2269, 2276], 'difluoride': [2270, 2277], 'membrane': [2271, 2278], '(Bio-Rad).': [2272], 'blocking': [2274, 2900], 'nonfat': [2281], 'milk': [2282], '1x': [2285], 'Tween-20': [2289], 'overnight,': [2290], 'immunoblottings': [2291], '2': [2298, 2474], '(1:1000).': [2300], 'Secondary': [2301], 'anti-rabbit': [2302], 'Biotechnology)': [2306], '(1:20,000)': [2312], 'Tween-20,': [2320], 'enhanced': [2323, 2463, 2576, 3554], 'chemiluminescence': [2324], 'according': [2327], 'instructions': [2330], 'manufacturer': [2333], '(Enhanced': [2334], 'Luminal': [2335], 'Reagent,': [2336], 'NEN': [2337], 'Life': [2338], 'Science': [2339], 'Products).': [2340], '(26.Radisavljevic': [2349, 3946], 'George': [2351, 3948, 3968], 'Dries': [2353, 3950, 3972], 'D.J.': [2354, 3951, 3973], 'Gamelli': [2355, 3952], 'R.L.': [2356, 3655, 3953, 3967], 'Liq.': [2358, 3955], 'Chromatogr.': [2359, 3956], 'Relat.': [2360, 3957], 'Technol.': [2361, 3958], '1996;': [2362, 3959, 4340, 4373], '1061-1079Crossref': [2364, 3961], '(20)': [2366, 3963], '30': [2393, 2409, 2497, 2571], 'min.': [2394, 2410], 'starvation,': [2396], 'transfected': [2397, 2681], 'also': [2400, 3839, 4088], 'supernatants': [2412], 'collected,': [2414], 'detection': [2416], 'NO2': [2418], '+': [2419], 'NO3': [2420], 'anions': [2421], 'Griess': [2431], 'reaction,': [2432], 'spectrophotometric': [2434], 'analysis': [2435], 'Wsoftmax': [2440], 'computer': [2441], 'program.': [2442], 'elucidate': [2444, 2765], 'expression,': [2451, 2465, 2549], 'up': [2458], 'h.': [2461], 'maximal': [2467], 'reached': [2472], '(Fig.1': [2476, 2509], 'A).': [2477], '(NO': [2485], 'substrate),': [2486], 'earlier': [2493, 2588], 'time': [2494], 'point': [2495], '(Fig.': [2499, 2524, 2657, 2667, 2844, 2865, 2881, 2938, 2952, 2963, 2977, 3570, 4032, 4207], 'B).l-Arginine': [2501], 'alone': [2502, 2660, 2689], 'had': [2503, 2661], 'no': [2504, 2662, 4328], 'B).': [2510, 2528, 2733, 4209], 'No': [2511], 'change': [2512], 'level': [2515], '(the': [2519], 'internal': [2520], 'control)': [2521], '1,': [2525], 'A': [2526, 2731], 'expression.': [2538, 3194], 'delineate': [2540, 2670], 'determined': [2551], 'phosphorylation.': [2560, 4276], 'We': [2561, 2642, 2823, 2832, 4175, 4654], 'highly': [2566, 3109], '(Fig.2).': [2581], 'Phosphorylation': [2582], 'occurred': [2585], 'than': [2589], 'synergistic': [2596], 'stimulation': [2597], '(compare': [2602], 'Fig.': [2603, 2607, 3022], 'B': [2605], '2).': [2608], 'suggest': [2611], 'AKT.': [2622], 'test': [2624], 'used': [2635], 'nm).': [2641], 'completely': [2646, 3161], '3).': [2658, 2668, 4033], 'secretion': [2677, 3186], 'either': [2685, 2891], 'control,': [2692], '(wt-AKT),': [2696], '(mt-AKT),': [2699], '(myr-AKT)': [2703], 'construct.': [2704], 'constitutively': [2706, 4196], 'myr-AKT-HA': [2708, 4198], '(p': [2716], '<': [2717, 2847, 2868, 2884, 2941, 2955, 2965, 2980], '0.0005),': [2718, 2956], '(mt-AKT)': [2724], 'did': [2725], 'affect': [2727], '(Fig.4,': [2730], 'Efficiency': [2734], 'about': [2738], '55–60%,': [2739], 'co-transfection': [2743], 'pGFP': [2746], 'data': [2755, 2983, 4087], 'indicate': [2756], 'signaling.': [2763], 'whether': [2775], 'upon': [2788], 'treatment': [2792, 3170], 'migrated': [2827], 'response': [2829, 3317, 3851, 4459], 'demonstrated': [2833, 3005, 4177], '(V)': [2836], '(A)': [2841], '5,': [2845, 2866, 2882, 2939, 2953, 2978], 'p': [2846, 2867, 2883, 2940, 2954, 2979], '0.01)': [2848], '(V+A)': [2858], 'resulted': [2859], 'even': [2862], 'larger': [2863], '0.0001)': [2869, 2942], '0.001)': [2885], 'reduced': [2886], '(V+W),': [2896], '(V+I),': [2902], '(V+N),': [2908], '(V+WI),': [2919], 'specifically': [2921], 'neutralized': [2922], 'addition,': [2926, 3420], 'induced': [2931, 3166, 3651, 3803], '(VA+W),': [2946], '(VA+I)': [2951], '(VA+N)': [2962], '5,p': [2964], '0.001),': [2966], 'both': [2969], '(VA+WI)': [2976], '0.0001).': [2981], 'modulates': [2987], 'VEGF,': [3012, 3174, 3535], '(see': [3021], 'illustration': [3025], 'Ref.': [3027], '4.He': [3028], 'mainly': [3059], 'one': [3061, 3541], 'layer': [3062], 'lining': [3066], 'supported': [3070, 3222], 'lamina': [3077], '(27.Bradbury': [3078], 'M.W.': [3079], '1993;': [3082, 3118, 3737, 4003], '78:': [3083, 4374], '453-472Crossref': [3084], '(185)': [3087], 'characterized': [3093], 'complexly': [3096], 'arranged': [3097], 'tight': [3098], 'junction,': [3099], 'very': [3101], 'low': [3102], 'rate': [3103], 'transcytotic': [3105], 'vesicular': [3106], 'transport,': [3107], 'selective': [3110], '(28.Janzer': [3112], 'C.R.': [3113], 'Inherit.': [3115], 'Metab.': [3116], 'Dis.': [3117], '16:': [3119], '639-647Crossref': [3120], '(68)': [3123], 'Using': [3126], 'plays': [3134, 3457], 'modulation': [3148], 'maintaining': [3213], 'Our': [3219, 4086], 'other': [3226, 3646, 4057, 4502], 'systems': [3228], 'such': [3229], 'aortic': [3232, 3243, 3898], 'where': [3235], 'inducer': [3240], '5.Bernatchez': [3278], 'embryonic': [3306], 'development,': [3307], 'wound': [3308], 'repair,': [3309], 'formation,': [3311], 'metastasis,': [3313], 'inflammatory': [3315], 'immune': [3316], '8.Benjamin': [3373], '10.Veikkola': [3404], 'reported': [3424, 4149], 'pial': [3430], 'microcirculation': [3431], 'rats': [3433], 'NOS/cGMP-dependent': [3436], 'Thus,': [3455], 'integrity.': [3471, 4653], 'actively': [3474], 'facilitating': [3477], 'T': [3478], 'lymphocyte': [3479], '25.Durieu-Trautmann': [3503], 'link': [3532], 'components': [3534], 'NO,': [3537], 'integrated': [3542, 4634], 'Specifically,': [3544], '6).': [3571], 'shown': [3578, 3786, 4043], 'transduce': [3580], 'cytoskeleton': [3588], 'transendothelial': [3592], 'lymphocytes': [3595], 'member': [3624], 'immunoglobulin': [3627], 'superfamily,': [3628], 'resting': [3632], 'cells.': [3634], 'activated': [3640], 'markedly': [3650], 'inflammation': [3653], '(29.Zhang': [3654], 'Chopp': [3656], 'Zaloga': [3658], 'Zhang': [3660], 'Z.G.': [3661], 'Jiang': [3662], 'Gautam': [3664], 'S.C.': [3665], 'Tang': [3666], 'W.X.': [3667], 'Tsang': [3668], 'Anderson': [3670], 'D.C.': [3671], 'Manning': [3672], '682:': [3677], '182-188Crossref': [3678], '(152)': [3681], '30.Freyer': [3684], 'Manz': [3686], 'Ziegenhorn': [3688], 'Weih': [3690], 'Angstwurm': [3692], 'Docke': [3694], 'W.D.': [3695], 'Meisel': [3696], 'Schumann': [3698], 'R.R.': [3699], 'Schonfelder': [3700], 'Weber': [3704], 'J.R.': [3705], '163:': [3709], '4308-4314PubMed': [3710], 'infections': [3713], '31.Gearing': [3731], 'A.J.': [3732], 'Newman': [3733], 'Today.': [3736], '14:': [3738], '506-512Abstract': [3739], '(1278)': [3745], '(19.Etienne': [3750], 'although': [3769], 'pathological': [3771], 'significance': [3772], 'yet': [3774], 'determined.': [3777], 'Flk-1/KDR': [3779], 'receptor': [3780], 'PI3K/AKT': [3782, 4031, 4404], 'signal': [3783], 'transduction': [3784], 'elements': [3790], 'process': [3793], 'umbilical': [3799, 3846, 4061, 4518], 'vein': [3800, 3847, 4062, 4519], '(32.Gerber': [3806], 'McMurtrey': [3808], 'Kowalski': [3810], 'Yan': [3812], 'Keyt': [3814], 'B.A.': [3815], 'Dixit': [3816], 'Ferrara': [3818], '273:': [3824], '30336-30343Abstract': [3825], '(1746)': [3833], 'angiopoietin-1': [3853], '(33.Fujikawa': [3854], 'Scherpenseel': [3856], 'I.A.': [3857], 'Jain': [3858], 'S.K.': [3859], 'Presman': [3860], 'Varticovski': [3862], '663-672Crossref': [3869], '(125)': [3872], 'stimulator': [3879, 4024], 'prostacyclin-prostaglandin': [3883], 'I2': [3884], 'within': [3891], 'smooth': [3893], 'muscle': [3894], 'causing': [3901], 'cGMP': [3902], 'NO-cGMP': [3905], 'thought': [3908], 'vasoactive': [3916], 'generation': [3943], 'oxidation': [3945], '34.Gamelli': [3966], 'Sharp-Pucci': [3970], 'Radisavljevic': [3974], 'Trauma.': [3977], '39:': [3979], '869-878Crossref': [3980], '(62)': [3983], '35.Ignarro': [3986], 'L.J.': [3987], 'Fukuto': [3988], 'Griscavage': [3990], 'Rogers': [3992], 'N.E.': [3993], 'Byrns': [3994], 'R.E.': [3995], '90:': [4004], '8103-8107Crossref': [4005], '(759)': [4008], 'our': [4012, 4045, 4451, 4609], 'able': [4016], 'downstream': [4036, 4152], 'signaling,': [4041], '(Figs.': [4049], '2),': [4052], '(36.Dimmeler': [4065, 4234, 4428, 4522], 'Fleming': [4067, 4236, 4367, 4430, 4524], 'Fisslthaler': [4069, 4238, 4432, 4526], 'Hermann': [4071, 4240, 4385, 4434, 4528], 'Busse': [4073, 4242, 4369, 4436, 4530], 'Zeiher': [4075, 4244, 4389, 4438, 4532], 'Nature.': [4077, 4246, 4305, 4440, 4534, 4560], '399:': [4079, 4248, 4307, 4442, 4536, 4562], '601-605Crossref': [4080, 4249, 4443, 4537], '(3056)': [4083, 4252, 4446, 4540], '37.Shen': [4125], 'B.Q.': [4126], 'Lee': [4127], 'D.Y.': [4128], 'Zioncheck': [4129], 'T.F.': [4130, 4300, 4555], '33057-33063Abstract': [4136], '(261)': [4144], '(38.Datta': [4159], 'S.R.': [4160, 4580], 'Brunet': [4161], 'Greenberg': [4163], 'M.E.': [4164], 'Genes': [4165], '2905-2927Crossref': [4169], '(3729)': [4172], 'caused': [4200], '4': [4208], 'serine/threonine': [4211], 'AKT/PKB': [4214], 'eNOS': [4218, 4257, 4271, 4414, 4427], 'phosphorylation,': [4227], 'phosphorylates': [4256], 'serine': [4259, 4417, 4420], '1177': [4260], 'enzyme': [4264], 'production,': [4268], '(S1179A)': [4272], 'resistant': [4274], 'Stimuli': [4277], 'promote': [4279], 'act': [4282], 'mechanism': [4286], '(39.Fulton': [4287], 'Gratton': [4289, 4544], 'J.P.': [4290, 4545], 'McCabe': [4291, 4546], 'T.J.': [4292, 4547], 'Fontana': [4293, 4548], 'Fujio': [4295, 4550], 'Y.': [4296, 4463, 4551], 'Walsh': [4297, 4464, 4552], 'Franke': [4299, 4554], 'Papapetropoulos': [4301, 4556], 'Sessa': [4303, 4558], '597-601Crossref': [4308, 4563], '(2239)': [4311, 4566], 'However,': [4314], 'calcium,': [4318], 'insulin,': [4319], 'shear': [4321], 'stress': [4322], 'acting': [4323], 'PI3K-independent': [4325], '(40.Zeng': [4333], 'Quon': [4335], 'M.J.': [4336, 4349], 'Clin.': [4338], 'Invest.': [4339], '894-898Crossref': [4342], '(667)': [4345], '41.Kuchan': [4348], 'Frangos': [4350], '266:': [4356], 'C628-C636Crossref': [4357], '42.Ayajiki': [4361], 'Kindermann': [4363], 'Hecker': [4365], 'Circ.': [4371, 4391], '750-758Crossref': [4375], '(267)': [4378], '43.Dimmeler': [4381], 'Assmus': [4383], 'Haendeler': [4387], '83:': [4394], '334-342Crossref': [4395], '(371)': [4398], 'Inhibition': [4401], 'mutation': [4407], 'site': [4411], '(at': [4416], '1177)': [4418], 'prevents': [4423], 'Based': [4449], 'results,': [4452], 'cytoprotection': [4455], '(44.Fujio': [4462], '16349-16354Abstract': [4471], '(491)': [4479], 'directly': [4484, 4507], 'agreement': [4497], 'reports': [4503], 'demonstrating': [4504], 'influences': [4508], 'COS-7': [4514], 'Scholar,39.Fulton': [4542], '45.Gallis': [4569], 'Corthals': [4571], 'Goodlett': [4573], 'D.R.': [4574], 'Ueba': [4575], 'Kim': [4577, 4681], 'Presnell': [4579], 'Figeys': [4581], 'Harrison': [4583], 'Berk': [4585], 'B.C.': [4586], 'Aebersold': [4587], 'Corson': [4589], 'M.A.': [4590], '30101-30108Abstract': [4596], '(286)': [4604], 'Taken': [4607], 'together,': [4608], 'demonstrates': [4611], 'ICAM-1.': [4630], 'insight': [4635], 'thank': [4655], 'Yiming': [4656], 'Dr.': [4659, 4679], 'Huchun': [4660], 'Li': [4661], 'valuable': [4664], 'help': [4665, 4675], 'performing': [4667], 'experiments': [4668], 'Philip': [4672], 'Chun': [4673], 'preparation,': [4678], 'Tae': [4680], 'advice,': [4683], 'Daniel': [4684], 'Kelley': [4685], 'graphic': [4688], 'work,': [4689], 'Janet': [4691], 'Delahanty': [4692], 'editing': [4694], 'manuscript.': [4696]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031511203', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-14T01:43:49.792051', 'created_date': '2016-06-24'}
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