Publication Information

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'https://openalex.org/W4241582355', 'https://openalex.org/W3015815503', 'https://openalex.org/W2471275172', 'https://openalex.org/W2386455785', 'https://openalex.org/W2046329404', 'https://openalex.org/W1991507260', 'https://openalex.org/W1936396226', 'https://openalex.org/W1156698136'], 'abstract_inverted_index': {'In': [0, 195, 2591, 2995, 3590, 3855], 'our': [1, 196, 4178], 'study,': [2, 197], 'we': [3, 198, 1134, 2931, 3383, 3483, 3527, 3971, 4038, 4241], 'characterized': [4, 199], 'the': [5, 68, 84, 88, 97, 116, 126, 138, 144, 167, 200, 263, 279, 283, 292, 311, 321, 333, 339, 362, 516, 534, 538, 547, 612, 616, 832, 983, 993, 997, 1020, 1110, 1116, 1166, 1301, 1312, 1321, 1326, 1333, 1348, 1353, 1366, 1377, 1396, 1440, 1444, 1473, 1500, 1504, 1512, 1543, 1547, 1552, 1645, 1649, 1656, 1736, 1767, 1797, 1813, 1823, 1848, 1915, 1943, 1950, 1956, 1994, 2019, 2044, 2048, 2071, 2118, 2133, 2153, 2169, 2347, 2383, 2394, 2399, 2422, 2470, 2473, 2480, 2531, 2575, 2594, 2676, 2681, 2690, 2762, 2771, 2810, 2819, 2927, 2980, 3025, 3032, 3106, 3153, 3183, 3188, 3192, 3202, 3224, 3230, 3234, 3245, 3473, 3489, 3499, 3502, 3506, 3514, 3523, 3529, 3533, 3543, 3547, 3554, 3558, 3561, 3582, 3586, 3601, 3608, 3623, 3653, 3710, 3774, 3806, 3828, 3833, 3841, 3921, 3935, 3955, 3982, 3997, 4003, 4025, 4030, 4034, 4042, 4102, 4128, 4136, 4147, 4162, 4174, 4190, 4198, 4204, 4209, 4217, 4226, 4243, 4246, 4253, 4262, 4274, 4293, 4319, 4324, 4348, 4357, 4373, 4377, 4398, 4407, 4421, 4428, 4442, 4451, 4461, 4477, 4485, 4540, 4562, 4570], 'substrate': [6, 39, 177, 201, 234, 372, 985, 1138, 1958, 2023, 2072, 2237, 2465, 2607, 2928, 3001, 3015, 3116, 3163, 3476, 3807, 3817, 3872, 4155, 4298, 4304, 4538, 4551], 'recognition': [7, 178, 202, 373, 986, 1185, 1367, 3347, 3381, 4156], 'properties': [8, 203], 'of': [9, 30, 54, 67, 78, 130, 153, 192, 204, 225, 249, 262, 273, 325, 348, 387, 411, 419, 615, 627, 647, 829, 885, 982, 988, 996, 1017, 1112, 1127, 1129, 1150, 1155, 1165, 1291, 1300, 1307, 1325, 1336, 1350, 1356, 1368, 1371, 1379, 1383, 1395, 1443, 1472, 1542, 1551, 1655, 1659, 1718, 1770, 1799, 1805, 1811, 1826, 1850, 1898, 1910, 1928, 1932, 1953, 1955, 1962, 1988, 2022, 2047, 2070, 2080, 2155, 2158, 2236, 2240, 2251, 2303, 2335, 2396, 2398, 2433, 2458, 2464, 2472, 2479, 2507, 2574, 2606, 2683, 2692, 2747, 2802, 2890, 2898, 2908, 2979, 2999, 3010, 3012, 3079, 3090, 3137, 3175, 3187, 3209, 3214, 3223, 3368, 3459, 3501, 3516, 3535, 3560, 3585, 3607, 3644, 3647, 3679, 3709, 3773, 3816, 3822, 3830, 3832, 3848, 3884, 3892, 3916, 3937, 3954, 3967, 3975, 4024, 4027, 4092, 4141, 4149, 4161, 4168, 4206, 4219, 4225, 4256, 4276, 4283, 4290, 4328, 4360, 4376, 4388, 4427, 4476, 4480, 4487], 'membrane': [10, 205, 392, 539, 549], 'type-1': [11, 206, 393, 603], 'matrix': [12, 207, 390, 604, 648, 716], 'metalloproteinase': [13, 208, 391, 605], '(MT1-MMP;': [14, 209, 606], 'also': [15, 210, 476, 607, 1008, 1273, 1492, 3640], 'known': [16, 211, 608, 720, 4489, 4544], 'as': [17, 212, 522, 609, 632, 634, 890, 1178, 1668, 1985, 2177, 2461, 3043, 3113, 3121, 3160, 3168, 3692, 3756, 4393, 4433, 4456], 'MMP-14),': [18, 213], 'a': [19, 76, 120, 154, 170, 214, 271, 315, 349, 365, 409, 417, 552, 556, 625, 645, 1179, 1289, 1308, 1317, 1361, 1392, 1625, 1723, 1802, 1843, 1986, 2247, 2252, 2442, 2462, 2581, 2599, 2612, 2905, 2996, 3127, 3343, 3592, 3618, 3743, 3813, 4123, 4185, 4220, 4281, 4297, 4303, 4337, 4547], 'key': [20, 215, 4186, 4457], 'enzyme': [21, 216, 1900, 1944, 2032, 2035], 'in': [22, 183, 217, 378, 416, 1498, 1609, 1644, 1752, 1785, 1847, 1864, 1893, 2056, 2082, 2168, 2265, 2282, 2350, 2410, 2511, 2894, 3126, 3196, 3233, 3353, 3375, 3416, 3431, 3449, 3475, 3505, 3672, 3715, 3727, 3742, 3779, 3791, 3836, 4014, 4019, 4047, 4069, 4105, 4127, 4189, 4322, 4413, 4463], 'tumor': [23, 218, 482], 'cell': [24, 219, 886, 899], 'invasion': [25, 220], 'and': [26, 107, 175, 221, 302, 370, 429, 485, 537, 618, 629, 653, 831, 894, 1019, 1106, 1115, 1175, 1181, 1281, 1285, 1315, 1328, 1375, 1451, 1453, 1460, 1482, 1503, 1511, 1517, 1531, 1611, 1618, 1622, 1629, 1648, 1661, 1666, 1739, 1746, 1762, 1764, 1783, 1817, 1819, 1873, 1925, 1991, 2041, 2096, 2136, 2229, 2315, 2382, 2421, 2643, 2701, 2753, 2804, 2988, 3019, 3058, 3066, 3068, 3077, 3119, 3166, 3191, 3363, 3426, 3452, 3481, 3629, 3688, 3729, 3752, 3793, 3868, 3874, 3934, 3989, 4002, 4009, 4060, 4200, 4430, 4453, 4528, 4537], 'metastasis.': [27, 222], 'A': [28, 223, 1434, 1507, 2105, 4313, 4473], 'panel': [29, 224], 'optimal': [31, 226, 1143], 'peptide': [32, 227, 1144, 2491, 2509, 2532, 2649, 3014, 3178, 3681, 3683, 3698, 3747, 3762, 3834, 3911, 4072, 4093, 4130, 4143, 4244, 4278, 4362], 'substrates': [33, 43, 82, 118, 134, 146, 228, 238, 277, 313, 329, 341, 711, 1145, 1151, 1162, 1172, 1275, 1294, 1304, 1330, 1372, 2243, 2492, 2650, 2806, 2903, 3035, 3095, 3142, 3213, 3241, 3352, 3369, 3415, 3441, 3508, 3588, 3835, 3957, 4202, 4229, 4412], 'for': [34, 56, 62, 104, 108, 110, 173, 229, 251, 257, 299, 303, 305, 368, 1119, 1146, 1295, 1365, 1376, 1522, 1639, 1884, 1945, 2099, 2139, 2233, 2276, 2317, 2325, 2367, 2429, 2488, 2523, 2918, 2992, 3072, 3446, 3492, 3620, 3862, 3909, 4044, 4064, 4249, 4300, 4344, 4367], 'MT1-MMP': [35, 63, 193, 230, 258, 388, 643, 709, 718, 897, 989, 1099, 1280, 1296, 1337, 1374, 1719, 1827, 1833, 1889, 1911, 1934, 2081, 2341, 2489, 2499, 2803, 2820, 2891, 2925, 2987, 3057, 3065, 3073, 3362, 3425, 3447, 3555, 3587, 3680, 3823, 4250, 4267, 4301, 4345, 4368, 4410, 4481], 'was': [36, 231, 1297, 1437, 1528, 1555, 1604, 1720, 1758, 1777, 1794, 1834, 1857, 1890, 1901, 1912, 1939, 1965, 1983, 2075, 2108, 2130, 2244, 2310, 2344, 2380, 2416, 2439, 2467, 2493, 2502, 2578, 2687, 2768, 2892, 3179, 3684, 3690, 3725, 3748, 3754, 3789, 3851, 3860, 3879, 3888, 4073, 4258, 4268, 4285, 4316, 4330, 4354, 4384, 4482, 4521], 'identified': [37, 232, 1274, 3384], 'using': [38, 233, 1391, 1557, 1735, 1970, 2173, 2246, 2495, 2580, 2611, 2744, 2809, 2818, 2926, 3912, 4531], 'phage': [40, 235, 1139, 1387, 2073, 2134, 2242, 2308, 2326, 2329, 2402, 2906, 2929, 3002, 3013, 3034, 3080, 3084, 3117, 3131, 3164, 3177, 3507, 3549, 3703, 3767, 3808], 'display.': [41, 236], 'The': [42, 181, 237, 376, 473, 525, 541, 980, 1464, 1489, 1525, 1600, 1615, 1715, 1741, 1754, 1773, 1854, 1887, 1896, 1930, 1980, 2112, 2123, 2147, 2164, 2272, 2377, 2456, 2485, 2572, 2603, 2705, 2800, 2887, 3094, 3141, 3171, 3211, 3351, 3414, 3440, 3573, 3642, 3697, 3761, 4067, 4117, 4437, 4518], 'can': [44, 147, 239, 342, 528, 3670, 4017], 'be': [45, 148, 240, 343, 529, 2758, 2922, 3037, 3103, 3150, 3373, 3438, 3511, 3598, 3964, 4231], 'segregated': [46, 241, 530, 3038], 'into': [47, 242, 531, 1456, 1631, 1766, 1779, 3039, 4318, 4356], 'four': [48, 243, 2387, 3040], 'groups': [49, 244, 1149, 3042, 3479], 'based': [50, 245, 3612], 'on': [51, 246, 1842, 2401, 3024, 3485, 3613, 4171], 'their': [52, 247, 1120, 2919, 3100, 3147, 3493, 3614, 3702, 3766, 4235], 'degree': [53, 248, 1349], 'selectivity': [55, 61, 109, 250, 256, 304, 1156, 3477, 3936, 4005, 4248, 4399], 'MT1-MMP.': [57, 111, 180, 252, 306, 375, 1130, 1147, 3093, 3140, 3497, 4050, 4158], 'Substrates': [58, 253], 'with': [59, 254, 624, 826, 992, 1152, 1606, 1613, 1760, 1788, 1914, 1993, 2077, 2142, 2258, 2332, 2389, 2412, 2441, 2504, 2647, 3496, 3566, 3686, 3750, 3864, 3881, 3947, 4245, 4260, 4347, 4524], 'poor': [60, 255], 'are': [64, 135, 186, 259, 330, 381, 408, 475, 544, 1173, 1277, 1345, 1750, 3096, 3143, 3194, 3357, 3420, 3448, 3713, 3719, 3777, 3783, 3979, 4543], 'comprised': [65, 260, 1163, 3366], 'predominately': [66, 261], 'Pro-X-X-↓-X': [69, 264, 1167], 'Hy': [70, 265], 'motif': [71, 266, 1186, 3247, 3341, 3348, 3382], 'that': [72, 115, 123, 267, 310, 318, 414, 708, 712, 883, 1276, 2616, 3248, 3370, 3442, 3464, 3520, 3577, 3634, 3652, 3669, 3973, 4053, 4135, 4153, 4180, 4305, 4409], 'is': [73, 102, 268, 297, 611, 719, 990, 1100, 1305, 1479, 1484, 2018, 2026, 2034, 2038, 2043, 3249, 3462, 3466, 3656, 4184, 4203, 4306], 'recognized': [74, 269, 1278, 3047, 3054, 3062, 4307], 'by': [75, 151, 179, 270, 346, 374, 550, 896, 1279, 1347, 1373, 1447, 1469, 1733, 1796, 1830, 1839, 1859, 1878, 1903, 2121, 2152, 2403, 2451, 2469, 2680, 2689, 2695, 2770, 2924, 2986, 3016, 3048, 3056, 3064, 3082, 3092, 3105, 3115, 3139, 3152, 3162, 3181, 3252, 3361, 3424, 3513, 3531, 3546, 3721, 3785, 3839, 3890, 3949, 4049, 4157, 4266, 4270, 4279, 4310, 4370, 4386, 4420, 4441], 'number': [77, 272, 418, 646, 3432], 'MMPs.': [79, 274, 4312], 'Highly': [80, 275], 'selective': [81, 117, 145, 174, 276, 312, 340, 369, 1293, 1327, 3071, 3445, 3968, 4199, 4236, 4299, 4443], 'lack': [83, 278, 3958, 3992], 'characteristic': [85, 280], 'Pro': [86, 141, 281, 336, 1309, 3219, 3225, 3465, 4207, 4221, 4291, 4353, 4389], 'at': [87, 96, 137, 157, 282, 291, 332, 352, 1311, 1320, 1352, 1439, 1458, 1519, 1624, 1881, 1967, 2102, 2144, 2262, 2269, 2279, 2320, 2370, 2426, 2453, 2476, 2526, 2651, 2697, 3229, 3600, 3622, 3637, 3960, 3994, 4029, 4164, 4182, 4208, 4222, 4292, 4326, 4382, 4390, 4539], 'P3': [89, 140, 284, 335, 1313, 1354, 4210, 4254, 4294, 4358, 4429], 'position;': [90, 285], 'instead': [91, 286], 'they': [92, 287], 'contain': [93, 288, 3218, 3663, 4054], 'an': [94, 289, 1124, 1136, 1494, 1879, 1971, 2306, 3379, 3605, 4169], 'Arg': [95, 290, 1319, 3621, 3636, 3668, 3959, 3993, 4028, 4076, 4118, 4163, 4181, 4325, 4378], 'P4': [98, 293, 1322, 3624, 3638, 3654, 4013, 4031, 4056, 4165, 4183, 4327, 4383, 4452], 'position.': [99, 294, 1323, 3603, 3625, 4211], 'This': [100, 295, 3340, 4087, 4334], 'P4Arg': [101, 296], 'essential': [103, 298], 'efficient': [105, 300], 'hydrolysis': [106, 301, 1954, 2397, 2608, 2686, 3011, 3534, 3689, 3753, 3831, 3887, 3948, 4048, 4275], 'Molecular': [112, 307], 'modeling': [113, 308, 4469, 4563], 'indicates': [114, 309, 1338, 4146], 'adopt': [119, 314], 'linear': [121, 316], 'conformation': [122, 317], 'extends': [124, 319], 'along': [125, 320], 'entire': [127, 322], 'catalytic': [128, 323, 1334, 1657, 1716, 1824, 2888, 3021, 3556, 4478, 4519], 'pocket': [129, 324, 1335], 'MT1-MMP,': [131, 326, 2641, 3017, 3840, 3865], 'whereas': [132, 327], 'non-selective': [133, 150, 176, 328, 345, 371, 1161, 1329, 3212, 4201], 'kinked': [136, 331], 'conserved': [139, 334], 'residue.': [142, 337], 'Importantly,': [143, 338], 'made': [149, 344, 4317], 'insertion': [152, 347], 'proline': [155, 350], 'kink': [156, 351], 'P3,': [158, 353], 'without': [159, 354, 2110], 'significantly': [160, 355], 'reducing': [161, 356], 'overallk': [162, 357, 3923], 'cat/K': [163, 358, 2765, 2774, 3845, 3924, 3999, 4080, 4090, 4109, 4139, 4264, 4341, 4364], 'm': [164, 359, 1852, 2718, 2752, 2766, 2775, 3846, 3905, 3925, 4000, 4081, 4091, 4110, 4140, 4265, 4342, 4365], 'values.': [165, 360], 'Altogether': [166, 361], 'study': [168, 363], 'provides': [169, 364], 'structural': [171, 366, 1117, 1363, 3203, 3490], 'basis': [172, 367, 1118, 1364, 3491], 'findings': [182, 377, 4405], 'this': [184, 379, 1132, 1384, 1946, 3030, 4045, 4055, 4142, 4223, 4239, 4277, 4361, 4395, 4555], 'report': [185, 380], 'likely': [187, 382, 1101], 'to': [188, 383, 478, 546, 639, 721, 724, 1022, 1024, 1102, 1141, 1332, 1533, 1536, 1539, 1546, 1641, 1801, 1861, 1941, 2132, 2312, 2323, 2346, 2418, 2436, 2537, 2598, 2656, 2709, 2715, 2900, 2921, 3006, 3099, 3102, 3110, 3146, 3149, 3157, 3206, 3244, 3359, 3372, 3378, 3422, 3454, 3487, 3541, 3553, 3597, 3701, 3738, 3765, 3802, 3931, 3943, 3981, 4040, 4077, 4098, 4114, 4119, 4214, 4233, 4302, 4332, 4379, 4401, 4448, 4545, 4550, 4560], 'explain': [189, 384], 'several': [190, 385, 1010, 4150], 'aspects': [191, 386], 'biology.': [194, 389], 'MMP': [394, 526, 1184, 3346, 4536], 'bovine': [395], 'serum': [396], 'albumin': [397], 'enzyme-linked': [398], 'immunosorbent': [399], 'assay': [400, 2615], 'matrix-assisted': [401], 'laser': [402], 'desorption': [403], 'ionization': [404], 'time-of-flight': [405], 'Matrix': [406], 'metalloproteinases': [407], 'family': [410, 527], 'zinc-dependent': [412], 'proteases': [413], 'function': [415, 1987], 'physiologic': [420, 1105], 'remodeling': [421], 'events': [422], 'including': [423, 650, 1013], 'wound': [424], 'healing,': [425], 'mammary': [426], 'gland': [427], 'involution,': [428], 'bone': [430], 'resorption': [431], '(1Shapiro': [432], 'S.D.': [433, 3730, 3794], 'Curr.': [434, 450], 'Opin.': [435, 451], 'Cell': [436, 452, 505, 849, 944], 'Biol.': [437, 453, 506, 660, 690, 763, 914, 945, 965, 1200, 1236, 1257, 1684, 2214, 2629, 2729, 2947, 3268, 3304, 3325, 3399], '1998;': [438, 467, 507, 2846, 4510], '10:': [439], '602-608Crossref': [440], 'PubMed': [441, 457, 470, 493, 510, 577, 597, 670, 700, 745, 773, 816, 854, 875, 924, 949, 975, 1060, 1093, 1210, 1267, 1405, 1416, 1429, 1595, 1694, 1710, 2202, 2224, 2552, 2637, 2737, 2795, 2849, 2866, 2882, 2957, 2973, 3278, 3335, 3409, 4513], 'Scopus': [442, 458, 494, 511, 578, 598, 671, 701, 746, 774, 817, 855, 876, 925, 950, 976, 1061, 1094, 1211, 1246, 1268, 1406, 1417, 1430, 1596, 1695, 1711, 2203, 2225, 2553, 2568, 2796, 2850, 2867, 2883, 2958, 2974, 3279, 3314, 3336, 3410, 4514], '(617)': [443], 'Google': [444, 460, 471, 496, 513, 580, 600, 673, 703, 748, 776, 799, 819, 857, 878, 927, 952, 978, 1063, 1096, 1213, 1248, 1270, 1408, 1419, 1432, 1598, 1697, 1713, 2205, 2227, 2555, 2570, 2638, 2738, 2798, 2852, 2869, 2885, 2960, 2976, 3281, 3316, 3338, 3412, 4516], 'Scholar,': [445, 461, 497, 581, 674, 676, 749, 777, 800, 858, 928, 953, 1064, 1214, 1249, 1409, 1420, 1698, 2206, 2556, 2853, 2870, 2961, 3282, 3317], '2Basbaum': [446], 'C.B.': [447], 'Werb': [448], 'Z.': [449, 463, 1066], '1996;': [454, 662, 796, 813, 2863], '8:': [455, 2880], '731-738Crossref': [456], '(292)': [459], '3Werb': [462], 'Yan': [464], 'Y.': [465, 564, 585, 589, 682, 688, 732, 787, 793, 932, 1080], 'Science.': [466, 1401, 1425], '282:': [468], '1279-1280Crossref': [469], 'Scholar).': [472, 514, 601, 704, 879, 979, 1097, 1271, 1433, 1599, 1714, 2063, 2571, 2639, 2739, 2799, 2886, 2977, 3339, 3350, 3413, 4517], 'MMPs1': [474], 'linked': [477], 'pathophysiologic': [479, 636, 1107], 'conditions': [480], 'like': [481, 3667], 'progression,': [483], 'inflammation,': [484], 'arthritis': [486], '(4Seiki': [487], 'M.': [488, 499, 572, 591, 686, 740, 791, 810, 930, 942, 1036, 1040, 1255, 2187, 2562, 2785, 3323], 'APMIS.': [489], '1999;': [490, 1052, 1592], '107:': [491], '137-143Crossref': [492], '(274)': [495], '5Polette': [498], 'Birembaut': [500], 'P.': [501, 1030, 1575, 2560], 'Int.': [502, 869], 'J.': [503, 566, 659, 689, 734, 762, 870, 913, 943, 964, 1032, 1078, 1199, 1228, 1235, 1256, 1683, 2213, 2628, 2728, 2845, 2860, 2946, 3267, 3296, 3303, 3324, 3398, 4509], 'Biochem.': [504, 1706, 2548, 2969], '30:': [508], '1195-1202Crossref': [509], '(126)': [512], 'Consequently,': [515, 3434, 4159, 4372], 'MMPs': [517, 543, 3254], 'have': [518, 1103, 1176], 'been': [519, 622, 2618], 'explored': [520], 'aggressively': [521], 'drug': [523], 'targets.': [524], 'two': [532, 1339, 3649, 4414, 4465], 'groups,': [533], 'soluble': [535], 'type': [536], 'type.': [540], 'membrane-type': [542], 'tethered': [545], 'plasma': [548], 'either': [551, 1485], 'transmembrane': [553], 'domain': [554, 1717, 1825, 2889, 4479, 4520], 'or': [555, 1487, 3658, 3733, 3797], 'glycosylphosphatidylinositol': [557], 'linkage': [558], '(6Sato': [559, 727], 'H.': [560, 684, 728, 785, 789, 802, 936, 940, 1050, 1569, 2627, 2727, 2787, 2841, 4505], 'Takino': [561, 729, 805], 'T.': [562, 730, 783, 804, 806, 934, 1488, 1581, 1585], 'Okada': [563, 687, 731, 792, 937], 'Cao': [565, 733, 1071, 1079], 'Shinagawa': [567, 735], 'A.': [568, 736, 938, 1089, 1571, 2198, 2839, 2857, 3395, 4503], 'Yamamoto': [569, 737], 'E.': [570, 678, 738, 781, 839, 1190, 1565, 1587, 1674, 1702, 1781, 2175, 2937, 2965, 3258], 'Seiki': [571, 590, 685, 739, 790, 809, 941], 'Nature.': [573, 741], '1994;': [574, 742, 2565], '370:': [575, 743], '61-65Crossref': [576, 744], '(2367)': [579, 747], '7Kojima': [582], 'S.': [583, 587, 1034, 1088, 1196, 1680, 2197, 2779, 2943, 3264], 'Itoh': [584, 931], 'Matsumoto': [586], 'Masuho': [588], 'FEBS': [592, 811], 'Lett.': [593, 812], '2000;': [594, 872, 1090, 1238, 2549, 3306], '480:': [595], '142-146Crossref': [596], '(116)': [599], 'Membrane': [602], 'MMP-14)': [610], 'prototypic': [613], 'member': [614], 'MT-MMPs,': [617], 'its': [619, 823, 4488], 'expression': [620, 1793], 'has': [621, 710, 2617, 4166], 'associated': [623], 'variety': [626], 'cellular': [628], 'developmental': [630], 'processes,': [631], 'well': [633, 2314, 4309], 'multiple': [635, 1104], 'conditions.': [637], 'Similar': [638, 2740], 'most': [640], 'other': [641, 3965, 3977, 4438], 'MMPs,': [642], 'cleaves': [644], 'proteins': [649], 'collagen,': [651], 'fibronectin,': [652], 'vitronectin': [654], '(8Pei': [655], 'D.': [656, 2835, 4499], 'Weiss': [657], 'S.J.': [658, 1188, 1216, 1672, 1700, 2935, 2963, 3256, 3284, 3389], 'Chem.': [661, 691, 764, 915, 966, 1201, 1237, 1258, 1685, 2215, 2564, 2630, 2730, 2948, 3269, 3305, 3326, 3400], '271:': [663], '9135-9140Abstract': [664], 'Full': [665, 667, 695, 697, 768, 770, 919, 921, 970, 972, 1055, 1057, 1205, 1207, 1241, 1243, 1262, 1264, 1689, 1691, 2219, 2221, 2634, 2734, 2952, 2954, 3273, 3275, 3309, 3311, 3330, 3332, 3404, 3406], 'Text': [666, 668, 696, 698, 769, 771, 920, 922, 971, 973, 1056, 1058, 1206, 1208, 1242, 1244, 1263, 1265, 1690, 1692, 2220, 2222, 2635, 2735, 2953, 2955, 3274, 3276, 3310, 3312, 3331, 3333, 3405, 3407], 'PDF': [669, 699, 772, 923, 974, 1059, 1209, 1245, 1266, 1693, 2223, 2636, 2736, 2956, 3277, 3313, 3334, 3408], '(364)': [672], '9-Google': [675], '10Ohuchi': [677], 'Imai': [679], 'K.': [680, 779, 808, 864, 1028, 1082, 2843, 2859, 4507], 'Fujii': [681, 786], 'Sato': [683, 788], '1997;': [692], '272:': [693], '2446-2451Abstract': [694], '(829)': [702], 'Other': [705], 'work': [706, 881], 'shows': [707, 882], 'extend': [713], 'beyond': [714], 'extracellular': [715], 'proteins.': [717], 'convert': [722], 'pro-MMP-2': [723], 'active': [725, 1899, 1904, 1933], 'protease': [726, 2378], '11Strongin': [750], 'A.Y.': [751, 847, 868, 912, 963], 'Collier': [752], 'I.': [753, 1046, 3198], 'Bannikov': [754], 'G.': [755, 1230, 3298], 'Marmer': [756], 'B.L.': [757], 'Grant': [758], 'G.A.': [759], 'Goldberg': [760], 'G.I.': [761], '1995;': [765, 1259, 2199, 2216, 2879, 3327], '270:': [766, 1260, 2217, 3328], '5331-5338Abstract': [767], '(1435)': [775], '12Imai': [778], 'Ohuchi': [780], 'Aoki': [782], 'Nomura': [784], 'Cancer': [794], 'Res.': [795, 850], '56:': [797], '2707-2710PubMed': [798], '13Sato': [801], 'Kinoshita': [803], 'Nakayama': [807], '393:': [814], '101-104Crossref': [815], '(300)': [818], 'Scholar),': [820], 'apparently': [821], 'through': [822], 'trimolecular': [824], 'complex': [825, 994, 2050], 'tissue': [827, 1926], 'inhibitor': [828, 1917, 1927, 1989, 2039], 'metalloproteinase-2': [830], 'αvβ3integrin': [833], '(14Deryugina': [834], 'E.I.': [835, 860, 910, 955, 3387], 'Ratnikov': [836, 907, 956], 'B.': [837], 'Monosov': [838], 'Postnova': [840, 958], 'T.I.': [841, 959], 'DiScipio': [842], 'R.': [843, 1070, 1072, 1589, 2833, 4497], 'Smith': [844, 865, 1197, 1423, 1681, 1703, 2545, 2944, 2966, 3265, 3396], 'J.W.': [845, 866, 1198, 1682, 1704, 2546, 2945, 2967, 3266, 3397], 'Strongin': [846, 867, 911, 962], 'Exp.': [848], '2001;': [851, 916, 946, 967, 1202, 1686, 1707, 2949, 2970, 3270], '263:': [852], '209-223Crossref': [853], '(331)': [856], '15Deryugina': [859], 'Bourdon': [861], 'M.A.': [862], 'Jungwirth': [863], 'Cancer.': [871], '86:': [873], '15-23Crossref': [874], '(153)': [877], 'Recent': [880], 'cleavage': [884, 2486, 2576, 2601, 3360, 3423, 3562, 3645, 3875], 'surface': [887], 'molecules': [888], 'such': [889], 'CD44,': [891], 'pro-αv': [892], 'integrin,': [893], 'transglutaminase': [895], 'modulates': [898], 'migration': [900], '(16Belkin': [901], 'A.M.': [902], 'Akimov': [903], 'S.S.': [904, 1068], 'Zaritskaya': [905], 'L.S.': [906], 'B.I.': [908, 957], 'Deryugina': [909], '276:': [917, 1203, 1687, 2950, 3271], '18415-18422Abstract': [918], '(218)': [926], '17Kajita': [929], 'Chiba': [933], 'Mori': [935], 'Kinoh': [939], '153:': [947], '893-904Crossref': [948], '(613)': [951], '18Deryugina': [954], 'Rozanov': [960], 'D.V.': [961], '277:': [968, 3402], '9749-9756Abstract': [969], '(181)': [977], 'importance': [981], 'broad': [984], 'specificity': [987, 2763, 3842, 3873], 'consistent': [991], 'phenotype': [995], 'MT1-MMP-deficient': [998], 'mice.': [999], 'These': [1000, 1171, 1343, 1358, 3199, 4404], 'mice': [1001], 'exhibit': [1002], 'overt': [1003], 'dwarfism,': [1004], 'but': [1005, 2761], 'close': [1006], 'inspection': [1007], 'showed': [1009, 3996], 'additional': [1011, 1125, 2993, 4151], 'defects': [1012], 'arthritis,': [1014], 'delayed': [1015], 'ossification': [1016], 'bone,': [1018], 'inability': [1021], 'respond': [1023], 'angiogenic': [1025], 'stimuli': [1026], '(19Holmbeck': [1027], 'Bianco': [1029], 'Caterina': [1031], 'Yamada': [1033], 'Kromer': [1035], 'Kuznetsov': [1037], 'S.A.': [1038], 'Mankani': [1039], 'Robey': [1041], 'P.G.': [1042], 'Poole': [1043], 'A.R.': [1044], 'Pidoux': [1045], 'Ward': [1047], 'J.M.': [1048, 2876], 'Birkedal-Hansen': [1049, 2626, 2726, 2786], 'Cell.': [1051], '99:': [1053], '81-92Abstract': [1054], '(1102)': [1062], '20Zhou': [1065], 'Apte': [1067], 'Soininen': [1069], 'Baaklini': [1073], 'G.Y.': [1074], 'Rauser': [1075], 'R.W.': [1076], 'Wang': [1077], 'Tryggvason': [1081], 'Proc.': [1083, 2192], 'Natl.': [1084, 2193], 'Acad.': [1085, 2194], 'Sci.': [1086, 2195], 'U.': [1087, 2196], '97:': [1091], '4052-4057Crossref': [1092], '(683)': [1095], 'Clearly,': [1098], 'substrates.': [1108, 3210, 3824, 4193], 'Knowing': [1109], 'identity': [1111], 'these': [1113, 3240, 3469, 3648, 3856, 3900, 3938, 3976, 4015, 4464], 'substrates,': [1114, 3627, 4037], 'recognition,': [1121], 'would': [1122, 4230], 'provide': [1123, 1360], 'level': [1126], 'understanding': [1128], 'To': [1131, 2338, 2392, 3825, 4459], 'end,': [1133], 'used': [1135, 1891, 1940, 2232, 2893, 3005, 3861], 'unbiased': [1137], 'selection': [1140, 2107, 2899, 3091, 3138], 'identify': [1142], 'Four': [1148], 'varying': [1153], 'degrees': [1154], 'were': [1157, 1169, 1389, 1467, 1515, 1620, 1637, 1663, 1815, 1828, 1935, 2115, 2150, 2171, 2230, 2256, 2274, 2330, 2385, 2424, 2534, 2609, 2645, 2678, 2707, 2742, 2807, 2916, 2983, 2989, 3004, 3085, 3132, 3227, 3365, 3428, 3443, 3539, 3564, 3639, 3731, 3795, 3907, 4062, 4083, 4471, 4557, 4567], 'identified.': [1158, 1170, 1298], 'As': [1159], 'anticipated,': [1160], 'primarily': [1164, 3367, 4450], 'Hysequence': [1168], 'collagen-like': [1174, 3345], 'emerged': [1177], 'canonical,': [1180], 'generally': [1182, 3510], 'non-selective,': [1183], '(21Kridel': [1187, 1671, 2934, 3255], 'Chen': [1189, 1673, 1701, 2936, 2964, 3257], 'Kotra': [1191, 1675, 2938, 3259], 'L.P.': [1192, 1676, 2939, 3260], 'Howard': [1193, 1677, 2940, 3261, 3390], 'E.W.': [1194, 1678, 2941, 3262], 'Mobashery': [1195, 1679, 2942, 3263], '20572-20578Abstract': [1204, 1688, 2951, 3272], '(150)': [1212, 1696, 2959, 3280], '22Deng': [1215, 3283], 'Bickett': [1217, 3285], 'D.M.': [1218, 3286], 'Mitchell': [1219, 3287], 'J.L.': [1220, 3288], 'Lambert': [1221, 3289], 'M.H.': [1222, 3290], 'Blackburn': [1223, 3291], 'R.K.': [1224, 3292], 'Carter': [1225, 3293], 'H.L.': [1226, 3294], 'Neugebauer': [1227, 3295], 'Pahel': [1229, 3297], 'Weiner': [1231, 3299], 'M.P.': [1232, 3300], 'Moss': [1233, 3301], 'M.L.': [1234, 3302], '40:': [1239, 3307], '31422-31427Abstract': [1240, 3308], '(112)': [1247, 3315], '23Smith': [1250, 3318], 'M.M.': [1251, 3319], 'Shi': [1252, 3320], 'L.': [1253, 2181, 2185, 3321], 'Navre': [1254, 2186, 2784, 3322], '6440-6449Abstract': [1261, 3329], '(138)': [1269, 3337], 'We': [1272, 4133, 4212], 'both': [1282, 3662, 4311], 'gelatinases': [1283], '(MMP-2': [1284], 'MMP-9).': [1286], 'Most': [1287], 'significantly,': [1288], 'group': [1290, 3208, 3215, 3354, 3417, 3450, 3609, 3632, 3821, 3837, 4035, 4191, 4227, 4422, 4444], 'highly': [1292, 1302, 1380, 3444], 'Each': [1299, 3723, 3746, 3787, 3877], 'specific': [1303, 1381, 2027], 'devoid': [1306], 'residue': [1310, 4046, 4188], 'position': [1314, 1355, 3500, 3515, 3584, 3655, 4032, 4224, 4295, 4359], 'contains': [1316], 'critical': [1318], 'Modeling': [1324], 'bound': [1331], 'separate': [1340], 'binding': [1341, 4466], 'modes.': [1342, 4416], 'modes': [1344, 3966], 'distinguished': [1346], 'distortion': [1351], 'substrate.': [1357], 'observations': [1359], 'solid': [1362], 'distinct': [1369, 3041, 3494, 4415], 'classes': [1370], 'design': [1378], 'inhibitors': [1382], 'enzyme.': [1385], 'Substrate': [1386], 'libraries': [1388], 'generated': [1390, 1468, 4483], 'modified': [1393, 2248], 'version': [1394], 'fUSE5': [1397, 1457, 1619], 'phagemid': [1398], '(24Smith': [1399], 'G.P.': [1400, 1411, 1424], '1985;': [1402], '228:': [1403], '1315-1317Crossref': [1404], '(3063)': [1407], '25Smith': [1410], 'Gene.': [1412], '1993;': [1413, 2792], '128:': [1414], '1-2Crossref': [1415], '(64)': [1418], '26Scott': [1421], 'J.K.': [1422], '1990;': [1426], '249:': [1427], '386-390Crossref': [1428], '(1889)': [1431], 'FLAG': [1435, 1501, 2437], 'epitope': [1436, 1502, 2438], 'engineered': [1438], 'N': [1441, 1478, 3897], 'terminus': [1442], 'geneIII': [1445], 'protein': [1446], 'annealing': [1448, 1541], 'oligonucleotides': [1449], '5′-CCGGGTTTGTCGTCGTCGTCTTTGTAGTCGGTAC-3′': [1450], '5′-CGACTACAAAGACGACGACGACAAAC-3′': [1452], 'ligating': [1454], 'them': [1455], 'theKpnI': [1459], 'XbaI': [1461], 'restriction': [1462, 1744], 'sites.': [1463], 'random': [1465, 1505, 3235], 'hexamers': [1466], 'PCR': [1470, 1734, 1756], 'extension': [1471, 1544], 'template': [1474, 1490, 1513, 1548, 1553], 'oligonucleotide': [1475, 1491, 1509, 1514, 1545, 1554], '5′-GGGGAGGCCGACGTGGCCGTCATCAGGCGGCTCAGGC(NNK)6ACGGCCTCTGGGGCCGAAAC-3′,': [1476], 'where': [1477, 2016], 'any': [1480], 'nucleotide': [1481], 'K': [1483, 2004, 2717, 3904], 'G': [1486], 'encodes': [1493], 'SGGSG': [1495], 'linker': [1496], 'positioned': [1497], 'between': [1499, 3478, 4197, 4535], 'hexamer.': [1506], 'primer': [1508], '5′-AATTTCTAGTTTCGGCCCCAGAGGC-3′': [1510], 'mixed': [1516, 1621], 'heated': [1518], '65': [1520], '°C': [1521, 1538, 1883, 2322, 2428], '2': [1523, 2318, 2368, 2524], 'min.': [1524], 'heating': [1526], 'block': [1527], 'switched': [1529], 'off': [1530], 'allowed': [1532], 'cool': [1534], 'passively': [1535], '40': [1537, 3033], 'allow': [1540, 2324], 'oligonucleotide.': [1549], 'Elongation': [1550], 'performed': [1556, 1913, 2109, 3726, 3790], 'Sequenase': [1558], '(United': [1559], 'States': [1560], 'Biochemical,': [1561], 'Cleveland,': [1562], 'OH)': [1563], '(27Koivunen': [1564], 'Arap': [1566], 'W.': [1567, 2831, 2855, 3393, 4495], 'Valtanen': [1568], 'Rainisalo': [1570], 'Medina': [1572], 'O.P.': [1573], 'Heikkila': [1574], 'Kantor': [1576], 'C.': [1577, 2829, 4493], 'Gahmberg': [1578], 'C.G.': [1579, 2052], 'Salo': [1580], 'Konttinen': [1582], 'Y.T.': [1583], 'Sorsa': [1584], 'Rouslahti': [1586], 'Pasqualini': [1588], 'Nat.': [1590], 'Biotechnol.': [1591], '17:': [1593, 2847, 4511], '768-774Crossref': [1594], '(513)': [1597], 'final': [1601, 1803], 'cDNA': [1602, 1727], 'product': [1603, 1757], 'precipitated': [1605, 2151], 'ethanol,': [1607], 'resuspended': [1608], 'water,': [1610], 'digested': [1612, 1759], 'SfiI.': [1614], 'DNA': [1616, 3185], 'insert': [1617, 1646], 'ligated': [1623], '5:1': [1626], 'molar': [1627], 'ratio': [1628, 2471, 4343, 4366, 4400], 'electroporated': [1630], 'Escherichia': [1632], 'coli': [1633, 1782, 2176], 'MC1061(F−).': [1634], 'Several': [1635], 'phages': [1636, 2114, 2120, 2166], 'selected': [1638, 2673, 3081, 3189, 3849, 4063], 'sequencing': [1640, 3182], 'confirm': [1642], 'randomness': [1643], 'sequences': [1647, 3200], 'correct': [1650], 'reading': [1651], 'frame.': [1652], 'Recombinant': [1653, 1832], 'versions': [1654], 'domains': [1658], 'MMP-2': [1660, 3380, 3869], 'MMP-9': [1662, 2644, 3020, 3859, 3867], 'expressed,': [1664], 'purified,': [1665], 'activated': [1667], 'described': [1669, 2178, 2539, 2619, 3693, 3757], 'previously': [1670, 2179, 2540, 2620, 2933], '28Kridel': [1699, 2962], 'Anal.': [1705, 2547, 2563, 2968], '294:': [1708, 2971], '176-184Crossref': [1709, 2972], '(9)': [1712, 2975], 'amplified': [1721, 1755, 2172], 'from': [1722, 1836, 2117, 2305, 2654, 2815, 2824, 2904, 3029, 3468, 3631, 3805, 3928, 3941, 4075, 4095, 4111, 4484], 'human': [1724], 'Universal': [1725], 'QUICK-Clone': [1726], 'library': [1728, 2074, 2907], '(CLONTECH,': [1729], 'Palo': [1730], 'Alto,': [1731], 'CA)': [1732], 'primers': [1737], '5′-catatgTACGCCATCCAGGGTCTCAAATGG-3′': [1738], '5′-gaattcttaCCCTGACTCACCCCCATAAAGTTGC-3′.': [1740], 'NdeI': [1742, 1761], 'andEcoRI': [1743], 'sites': [1745, 1769], 'TAA': [1747], 'stop': [1748], 'codon': [1749], 'shown': [1751], 'lowercase.': [1753], 'EcoRI': [1763], 'cloned': [1765], 'corresponding': [1768, 3184], 'pFLAG-ATS': [1771], '(Sigma).': [1772], 'resulting': [1774, 3028], 'plasmid': [1775], '(pGM-MT1)': [1776], 'transformed': [1778, 2708], 'BL21(DE3)': [1780], 'grown': [1784], '2YT': [1786], 'supplemented': [1787], 'ampicillin': [1789], '(50': [1790, 2284, 2353], 'μg/ml).': [1791], 'Protein': [1792, 2877], 'induced': [1795], 'addition': [1798, 2154, 2682, 2691], 'isopropyl-1-thio-β-d-galactopyranoside': [1800], 'concentration': [1804, 1897, 1990], '0.1': [1806], 'mm.': [1807], 'After': [1808, 1948, 2299], '3': [1809, 1922], 'h': [1810, 2101, 2141, 2278, 2319, 2369, 2525], 'induction,': [1812], 'bacteria': [1814], 'collected': [1816], 'lysed,': [1818], 'inclusion': [1820, 1837], 'bodies': [1821, 1838], 'containing': [1822, 2295], 'isolated': [1829], 'centrifugation.': [1831], 'purified': [1835, 1855], 'anion-exchange': [1840], 'chromatography': [1841], 'MonoQ': [1844], 'column': [1845], '(AmershamBiosciences)': [1846, 2261], 'presence': [1849, 4148, 4205, 4218], '8': [1851], 'urea.': [1853], 'material': [1856], 'refolded': [1858, 1888], 'dilution': [1860], '100': [1862, 2088, 2156, 2358, 2505, 2517, 2655, 2664], 'μg/ml': [1863, 2079, 2264, 2409], '50': [1865, 1874, 2083, 2512, 2659, 2670], 'mm': [1866, 1871, 2084, 2089, 2092, 2285, 2290, 2354, 2361, 2513, 2518, 2521, 2660, 2665, 2668], 'HEPES,': [1867], 'pH': [1868, 2086, 2287, 2356, 2515, 2662], '7.0,': [1869], '5': [1870, 2078], 'CaCl2,': [1872, 2093, 2362, 2669], 'μm': [1875, 2506], 'ZnCl2,': [1876], 'followed': [1877, 2450, 2694], 'incubation': [1880, 2351], '12': [1882], '1': [1885, 2100, 2277, 2413, 2430], 'h.': [1886, 2431], 'immediately': [1892], 'activity': [1894, 2028, 3026], 'assays.': [1895], 'determined': [1902, 1966, 2494, 2579, 2688, 2759, 3180, 3565, 3852], 'site': [1905, 1908, 2487, 3232, 4556], 'titration.': [1906], 'Active': [1907], 'titration': [1909], 'hydroxomate': [1916], 'AG3340': [1918, 1938], '(K': [1919], 'i': [1920, 2005, 2012], '=': [1921, 1997, 2776], '×': [1923, 2067, 2910], '10−10m)': [1924], 'metalloproteinase-2.': [1929], 'titrations': [1931], 'equivalent;': [1936], 'thus': [1937], 'titrate': [1942], 'study.': [1947], 'pre-incubation,': [1949], 'steady-state': [1951, 1981, 2020], 'rate': [1952, 1982, 2021, 3829], 'fluorogenic': [1957], 'Mca-PLGL-Dnp-AR-NH2': [1959], '(Bachem,': [1960], 'King': [1961], 'Prussia,': [1963], 'PA)': [1964], 'ambient': [1968], 'temperature': [1969, 2281], 'fMax': [1972], 'fluorescence': [1973], 'microplate': [1974], 'reader': [1975], '(Molecular': [1976], 'Devices,': [1977], 'Sunnyvale,': [1978], 'CA).': [1979, 2163], 'plotted': [1984], 'fitted': [1992], 'equation': [1995, 2772], 'V': [1996, 2017], 'SA(E0': [1998], '−': [1999, 2007, 2014], '0.5{(E0': [2000], '+': [2001, 2003, 2009], 'I': [2002, 2010, 2037, 3216, 3480, 4423], ')': [2006, 3847], '[(E0': [2008], '+K': [2011], ')2': [2013], '4E0I]0.5}),': [2015], 'hydrolysis,': [2024, 2340, 2459, 2466, 2530], 'SA': [2025], '(rate': [2029], 'per': [2030], 'unit': [2031], 'concentration),E0': [2033], 'concentration.': [2036], 'concentration,': [2040], 'KI': [2042], 'dissociation': [2045], 'constant': [2046, 3843, 4559], 'enzyme-inhibitor': [2049], '(29Knight': [2051], 'Barrett': [2053], 'A.J.': [2054], 'Methods': [2055], 'Enzymology.': [2057], 'Academic': [2058], 'Press,': [2059], 'San': [2060, 2161], 'Diego1995:': [2061], '248Google': [2062], 'An': [2064, 4194], 'aliquot': [2065], '(2': [2066], '1010': [2068], 'phage)': [2069], 'incubated': [2076, 2138, 2316, 2425, 2503, 2646, 3685, 3749, 3880], 'Tris,': [2085, 2286, 2355, 2514], '7.4,': [2087, 2357, 2516], 'NaCl,': [2090, 2291, 2519, 2666], '10': [2091, 2296, 2360, 2520, 2667], '0.05%': [2094, 2097, 2363, 2365], 'Brij-35,': [2095], 'BSA': [2098], '37': [2103, 2371, 2527], '°C.': [2104, 2146, 2271, 2372, 2528], 'control': [2106], 'protease.': [2111, 2376, 2748], 'cleaved': [2113, 2165, 2984, 3251], 'separated': [2116], 'non-cleaved': [2119], 'immunodepletion.': [2122], 'M1': [2124], 'anti-FLAG': [2125, 2405, 2434], 'monoclonal': [2126], 'antibody': [2127, 2260, 2407, 2435, 2448], '(100': [2128], 'μg)': [2129], 'added': [2131, 2311, 2345, 2417], 'samples': [2135, 2482, 2533], 'then': [2137, 2231, 4522], '18': [2140], 'rocking': [2143], '4': [2145, 2270, 2321, 2427], 'phage-antibody': [2148], 'complexes': [2149, 2801], 'μl': [2157, 2302], 'Pansorbin': [2159], '(Calbiochem,': [2160], 'Diego,': [2162], 'remaining': [2167], 'supernatant': [2170, 2304], 'K91': [2174], '(30Ding': [2180], 'Coombs': [2182, 2209], 'G.S.': [2183, 2210], 'Strandberg': [2184], 'Corey': [2188, 2211], 'D.R.': [2189, 2212], 'Madison': [2190], 'E.L.': [2191, 2208], '92:': [2200], '7627-7631Crossref': [2201], '(89)': [2204], '31Madison': [2207], '7558-7562Abstract': [2218], '(73)': [2226], 'Scholar)': [2228], 'subsequent': [2234], 'rounds': [2235, 2897, 3089, 3136], 'selection.': [2238], 'Hydrolysis': [2239], 'individual': [2241, 2648, 3548], 'measured': [2245, 2440, 2610, 3114, 3161, 3889, 4084], 'ELISA.': [2249], 'Wells': [2250], '96-well': [2253], 'microtiter': [2254], 'plate': [2255], 'coated': [2257], 'anti-M13': [2259], '2.5': [2263], 'phosphate-buffered': [2266], 'saline': [2267], 'overnight': [2268, 2307], 'wells': [2273, 2349, 2374, 2384], 'blocked': [2275], 'room': [2280], 'TBST': [2283, 2411], '7.8,': [2288], '150': [2289, 2301], '0.2%': [2292], 'Tween': [2293], '20)': [2294], 'mg/ml': [2297, 2414], 'BSA.': [2298], 'blocking,': [2300], 'culture': [2309], 'each': [2313, 2419, 2508, 3176, 3207, 3820, 3910, 4070], 'capture.': [2327], 'Unbound': [2328], 'removed': [2331], 'three': [2333, 2895, 3050, 3088, 3107, 3135, 3154], 'washes': [2334], 'ice-cold': [2336, 2390], 'TBST.': [2337, 2391], 'assess': [2339], '(3.0': [2342], 'μg/ml)': [2343], 'appropriate': [2348], 'buffer': [2352], 'mmNaCl,': [2359], 'BSA,': [2364], 'Brij-35)': [2366], 'Control': [2373], 'lacked': [2375, 3635], 'solution': [2379], 'removed,': [2381], 'washed': [2386], 'times': [2388], 'determine': [2393, 2716, 3488, 4041, 4215], 'extent': [2395, 2457], 'peptides': [2400, 3193, 3544, 3611, 3650, 3712, 3776, 3850, 3939, 3978, 3987, 4052, 4525], 'proteinase,': [2404, 3687, 3751], 'polyclonal': [2406], '(1.8': [2408], 'BSA)': [2415], 'well,': [2420], 'plates': [2423], 'Binding': [2432], 'horseradish': [2443], 'peroxidase-conjugated': [2444], 'goat': [2445], 'anti-rabbit': [2446], 'IgG': [2447], '(Bio-Rad)': [2449], 'detection': [2452, 2696], '490': [2454, 2477], 'nm.': [2455, 2704], 'taken': [2460, 2823], 'measure': [2463, 4282], 'calculated': [2468], 'optical': [2474], 'density': [2475], 'nm': [2478, 2700], 'protease-treated': [2481], 'versus': [2483, 3918], 'controls.': [2484], 'within': [2490, 3819], 'MALDI-TOF': [2496, 2584, 3567], 'mass': [2497, 2573, 2585, 3568], 'spectrometry.': [2498], '(23': [2500], 'nm)': [2501], 'sample': [2510], 'CaCl2': [2522], 'Following': [2529, 3551], 'prepared': [2535], 'according': [2536, 3098, 3145], 'methods': [2538], '(32Landry': [2541], 'F.': [2542], 'Lombardo': [2543], 'C.R.': [2544], '279:': [2550], '1-8Crossref': [2551], '(83)': [2554], '33Vorm': [2557], 'O.': [2558], 'Roepstorff': [2559], 'Mann': [2561], '66:': [2566], '3281-3287Crossref': [2567], '(644)': [2569], 'products': [2577, 3563, 3646], 'Voyager': [2582], 'DE-RP': [2583], 'spectrometer': [2586], '(PerSeptive': [2587], 'Biosystems,': [2588], 'Framingham,': [2589], 'MA).': [2590], 'all': [2592, 3049, 3217, 3222], 'cases,': [2593], 'observed': [2595], 'fragments': [2596], 'corresponded': [2597], 'single': [2600], 'site.': [2602], 'kinetic': [2604], 'parameters': [2605], 'fluorescamine': [2613, 3893], 'incorporation': [2614, 3891], '(34Fields': [2621, 2721], 'G.B.': [2622, 2722], 'Van': [2623, 2723, 2788], 'Wart': [2624, 2724, 2789], 'H.E.': [2625, 2725, 2790], '1987;': [2631, 2731], '262:': [2632, 2732], '6221-6226Abstract': [2633, 2733], 'Briefly,': [2640], 'MMP-2,': [2642, 3018, 3059, 3364], 'concentrations': [2652, 3883], 'ranging': [2653], '800': [2657], 'μmin': [2658], 'Tricine,': [2661], '7.5,': [2663], 'μmZnCl2.': [2671], 'At': [2672], 'time': [2674], 'points': [2675], 'reactions': [2677], 'stopped': [2679], '1,10-phenanthroline.': [2684], 'Peptide': [2685, 3886], 'fluorescamine,': [2693], 'λex': [2698], '355': [2699], 'λem': [2702], '460': [2703], 'data': [2706], 'double': [2710, 3913], 'reciprocal': [2711, 3914], 'plots': [2712, 3915], '(1/[S]': [2713], 'versus1/vi)': [2714], 'andk': [2719, 4079], 'cat': [2720, 2755], 'results': [2741], 'obtained': [2743], 'different': [2745], 'batches': [2746], 'For': [2749, 3985, 4238], 'some': [2750, 3974], 'substrates,K': [2751], 'k': [2754, 2773, 3902, 4108, 4263], 'could': [2756, 3036, 3437, 3509], 'not': [2757, 3571, 3736, 3800], 'individually,': [2760], 'constant,k': [2764], ',': [2767], 'derived': [2769, 3908], 'vi/(E0)(S0)': [2777], '(35Netzel-Arnett': [2778], 'Sang': [2780], 'Q.X.': [2781], 'Moore': [2782], 'W.G.': [2783], 'Biochemistry.': [2791], '32:': [2793], '6427-6432Crossref': [2794], '(161)': [2797], 'cognate': [2805], 'modeled': [2808], 'Sybyl': [2811], 'software': [2812], 'package': [2813], 'available': [2814], 'Tripos': [2816], '(www.tripos.com)': [2817], 'spatial': [2821], 'structure': [2822, 4491], 'PDB': [2825], 'file': [2826], '1bqq': [2827], '(36Fernandez-Catalan': [2828, 4492], 'Bode': [2830, 4494], 'Huber': [2832, 4496], 'Turk': [2834, 4498], 'Calvete': [2836, 4500], 'J.J.': [2837, 4501], 'Lichte': [2838, 4502], 'Tschesche': [2840, 4504], 'Maskos': [2842, 4506], 'EMBO': [2844, 4508], '5238-5248Crossref': [2848, 4512], '(307)': [2851, 4515], '37Humphrey': [2854], 'Dalke': [2856], 'Schulten': [2858], 'Mol.': [2861], 'Graph.': [2862], '14:': [2864], '33-38Crossref': [2865], '(37521)': [2868], '38Wallace': [2871], 'A.C.': [2872], 'Laskowski': [2873], 'R.A.': [2874], 'Thornton': [2875], 'Eng.': [2878], '127-134Crossref': [2881], '(4297)': [2884], 'successive': [2896], 'isolate': [2901], 'optimum': [2902], '2.4': [2909], '108': [2911], 'independent': [2912], 'clones.': [2913, 3550], 'Two-hundred': [2914], 'clones': [2915, 2982], 'screened': [2917], 'ability': [2920, 3101, 3148], 'hydrolyzed': [2923, 3104, 3151], 'ELISA': [2930, 3118, 3165, 3809], 'reported': [2932], 'Forty': [2978], 'two-hundred': [2981], 'efficiently': [2985], 'carried': [2990], 'forward': [2991], 'analysis.': [2994, 4066], 'second': [2997], 'round': [2998], 'analysis,': [3000, 3031], 'ELISAs': [3003], 'compare': [3007], 'relative': [3008, 3109, 3156], 'rates': [3009], 'domains.': [3022], 'Based': [3023], 'profiles': [3027], 'follows:': [3044], '(i)': [3045], 'those': [3046, 3053, 3061, 3070], 'MMPS,': [3051], '(ii)': [3052], 'equally': [3055, 3063, 4308], '(iii)': [3060], 'MMP-9,': [3067, 3427, 4280], '(iv)': [3069], '(TableI).Table': [3074], 'IPeptide': [3075], 'sequence': [3076, 3174, 3377], 'grouping': [3078], 'MT1-MMPIndividual': [3083], 'analyzed': [3086, 3133], 'after': [3087, 3134], 'grouped': [3097, 3144], 'proteinases,': [3108, 3155], 'non-treated': [3111, 3158], 'controls,': [3112, 3159], 'expressed': [3120, 3167, 3228], '%': [3122, 3169], 'hydrolysis.': [3123, 3170], 'Open': [3124, 3740], 'table': [3125, 3741], 'new': [3128, 3744], 'tab': [3129, 3745], 'Individual': [3130], 'amino': [3172, 3579, 3594], 'acid': [3173, 3595, 3707, 3771], 'inserts': [3186], 'phage,': [3190], 'presented': [3195], 'Table': [3197], 'reveal': [3201], 'features': [3204], 'common': [3205], 'residues.': [3220], 'Interestingly,': [3221], 'residues': [3226, 3518], 'same': [3231, 4103], 'peptides.': [3236, 3537, 3984], 'Upon': [3237], 'first': [3238], 'inspection,': [3239], 'appear': [3242], 'similar': [3243, 3374, 3871, 4020, 4314], 'Pro-X-X-↓-Hy': [3246], 'commonly': [3250], 'many': [3253], 'represents': [3342], 'canonical': [3344], '(9-Google': [3349], 'II,': [3355], 'which': [3356, 3419, 3661, 3991, 4011, 4323], 'susceptible': [3358, 3421], 'appeared': [3371, 3453], 'primary': [3376], 'recently': [3385], '(39Chen': [3386], 'Kridel': [3388], 'E.W.,': [3391], 'Li,': [3392], 'Godzik': [3394], '2002;': [3401], '4485-4491Abstract': [3403], '(97)': [3411], 'III,': [3418], 'relatively': [3429], 'small': [3430], 'however.': [3433, 3471], 'no': [3435], 'consensus': [3436], 'defined.': [3439], 'IV': [3451, 3610, 3633, 3838, 4036, 4192, 4228, 4445], 'give': [3455], 'little': [3456], 'initial': [3457], 'indication': [3458], 'consensus.': [3460], 'It': [3461], 'noteworthy': [3463], 'absent': [3467], 'peptides,': [3470, 3922, 4016, 4424, 4446], 'Given': [3472], 'contrast': [3474], 'IV,': [3482], 'focused': [3484], 'trying': [3486], 'reactivity': [3495], 'Although': [3498], 'scissile': [3503, 3615], 'bond': [3504], 'surmised': [3512], 'hydrophobic': [3517, 3578, 3673, 4021], '(Leu/Ile)': [3519], 'normally': [3521], 'occupy': [3522, 4012], 'deep': [3524], 'S1′': [3525, 4541], 'pocket,': [3526], 'confirmed': [3528, 3576], 'placements': [3530], 'analyzing': [3532], 'synthetic': [3536, 4071], 'Peptides': [3538], 'synthesized': [3540], 'mimic': [3542], 'displayed': [3545], 'exposure': [3552], 'domain,': [3557], 'masses': [3559, 3643], 'spectrometry': [3569], '(data': [3570], 'shown).': [3572], 'MALDI': [3574], 'analysis': [3575, 3678], 'acids': [3580], 'occupied': [3581], 'P1′': [3583, 4431, 4454], '(TableII).': [3589], 'addition,': [3591], 'polar': [3593], 'appears': [3596, 4447], 'preferred': [3599], 'P2′': [3602], 'Furthermore,': [3604], 'alignment': [3606], 'bonds': [3616, 3718, 3782], 'demonstrates': [3617], 'preference': [3619, 3818], 'Two': [3626, 4565], 'A20': [3628], 'A167,': [3630], 'examined.': [3641], 'indicate': [3651, 3812], 'Phe': [3657, 4008], 'Lys,': [3659, 4010], 'respectively,': [3660], 'long': [3664], 'side': [3665], 'chains': [3666], 'participate': [3671, 4018], 'interactions': [3674, 4534, 4553], '(see': [3675], 'below).Table': [3676], 'IIKinetic': [3677], 'substratesEach': [3682], 'detected': [3691, 3755], 'under': [3694, 3758], '"Experimental': [3695, 3759], 'Procedures."': [3696, 3760], 'names': [3699, 3763], 'correspond': [3700, 3764], 'clone': [3704, 3768], 'designation.': [3705, 3769], 'Amino': [3706, 3770], 'changes': [3708, 3772], 'variant': [3711, 3775], 'indicated': [3714, 3720, 3778, 3784], 'bold.': [3716, 3780], 'Scissile': [3717, 3781], '↓.': [3722, 3786], 'experiment': [3724, 3788], 'triplicate,': [3728, 3792], '15%': [3732, 3796], 'below.': [3734, 3798], 'NA,': [3735, 3799], 'able': [3737, 3801], 'detect.': [3739, 3803], 'Results': [3804], '(Table': [3810, 3853, 4085], 'I)': [3811], 'rank': [3814], 'order': [3815], 'quantify': [3826], 'precisely': [3827], '(k': [3844], 'II).': [3854, 4086], 'studies': [3857, 4470], 'only': [3858, 4271], 'comparisons': [3863], 'because': [3866], 'share': [3870], 'efficiency.': [3876], 'proteinase': [3878], 'increasing': [3882], 'peptide.': [3885, 4350], 'onto': [3894], 'newly': [3895], 'formed': [3896], 'termini.': [3898], 'From': [3899], 'measurements,': [3901], 'catand': [3903], 'values': [3906, 3926, 4001, 4082], '1/[S]': [3917], '1/vi.': [3919], 'Among': [3920], 'ranged': [3927, 3940], '8,200': [3929], 'M−1s−1': [3930, 4097, 4113], '777,200': [3932], 'M−1s−1,': [3933], '2.2-': [3942], '83-fold': [3944], 'when': [3945, 4352], 'compared': [3946, 4346], 'MMP-9.': [3950, 4403], 'Because': [3951, 4023, 4533], 'nearly': [3952], 'one-half': [3953], 'MT1-MMP-selective': [3956], 'P4,': [3961, 3995], 'there': [3962], 'may': [3963], 'recognition.': [3969], 'Nevertheless,': [3970], 'suspect': [3972, 4134], 'related': [3980], 'Arg-containing': [3983], 'example,': [3986], 'A167': [3988], 'A20,': [3990], 'lowestk': [3998], 'lowest': [4004], 'ratios.': [4006], 'Yet,': [4007, 4351], 'interactions.': [4022], 'preponderance': [4026], 'among': [4033], 'sought': [4039, 4213], 'requirement': [4043], 'Three': [4051], 'Arg,': [4057], 'A42,': [4058], 'B175,': [4059], 'A176,': [4061], 'mutational': [4065, 4175], 'P4position': [4068], 'changed': [4074, 4331], 'Ala,': [4078], 'substitution': [4088, 4104, 4121, 4160, 4289, 4315, 4335, 4381, 4387, 4396], 'decreasedk': [4089], 'A176': [4094, 4257, 4329, 4526], '49,100': [4096], '5,900': [4099], 'M−1s−1.': [4100, 4116], 'Similarly': [4101], 'B175': [4106], 'reduced': [4107, 4269], '63,600': [4112], '10,400': [4115], 'Ala': [4120, 4380], 'had': [4122], 'less': [4124, 4167], 'significant': [4125], 'effect': [4126, 4170, 4375], 'A42': [4129], '(3-fold': [4131], 'reduction).': [4132], 'very': [4137], 'highk': [4138], '(777,200': [4144], 'M−1s−1)': [4145], 'contacts': [4152], 'favor': [4154, 4402], 'A42.': [4172], 'Altogether,': [4173], 'analyses': [4176], 'support': [4177, 4406], 'hypothesis': [4179], 'contact': [4187, 4435], 'obvious': [4195], 'distinction': [4196], 'whether': [4216], 'sufficient': [4232], 'override': [4234], 'docking.': [4237], 'purpose,': [4240], 'chose': [4242], 'highest': [4247], '(A176).': [4251], 'When': [4252], 'Ser': [4255], 'replaced': [4259], 'Pro,': [4261], '32%.': [4272], 'Conversely,': [4273], 'selectivity,': [4284], 'increased': [4286, 4369], '58-fold.': [4287], 'Hence,': [4288], 'converted': [4296], 'A176A': [4320], 'peptide,': [4321], 'Ala.': [4333], 'caused': [4336], '9-fold': [4338], 'reduction': [4339], 'ink': [4340], 'parent': [4349], 'substituted': [4355], 'thek': [4363], '∼6-fold.': [4371], 'deleterious': [4374], 'rescued': [4385], 'P3.': [4391], 'Equally': [4392], 'significant,': [4394], 'reversed': [4397], 'idea': [4408], 'recognizes': [4411], 'One': [4417], 'mode,': [4418, 4439], 'demonstrated': [4419, 4440], 'makes': [4425], 'use': [4426, 4449], 'positions': [4432], 'dominant': [4434], 'points.': [4436], 'subsites': [4455], 'contacts.': [4458], 'visualize': [4460], 'differences': [4462], 'modes,': [4467], 'molecular': [4468], 'conducted.': [4472], 'three-dimensional': [4474], 'model': [4475], 'coordinates': [4486], 'crystal': [4490], 'docked': [4523], '(Ac-SGRSEN↓IRTA-NH2)': [4527], 'A176P': [4529], '(Ac-SGRPEN↓IRTA-NH2)': [4530], 'Sybyl.': [4532], 'subsite': [4542], 'make': [4546], 'major': [4548], 'contribution': [4549], 'binding,': [4552], 'around': [4554], 'kept': [4558], 'constrain': [4561], 'procedure.': [4564], 'restrictions': [4566], 'applied.': [4568], 'First,': [4569], 'hydrogen': [4571]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031495896', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-09T11:00:47.906169', 'created_date': '2016-06-24'}