Type I Interferon Receptors: Biochemistry and Biological Functions

Name: Work Video:
Duration: 3 min 30 s
Nicole A. de Weerd; Shamith A. Samarajiwa; Paul J. Hertzog
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5633, 5645, 5667], 'transcription.': [59], 'receptor': [60, 155, 523, 1122, 1345, 1493, 1499, 2053, 2117, 3124, 3287, 3303, 3492, 4170, 4215, 4270, 4278, 4282, 4608, 5452, 5466, 5635, 5650], '(IFNAR)': [61], 'is': [62, 80, 444, 506, 853, 1081, 1340, 1625, 1659, 2495, 2500, 2690, 2889, 3107, 3118, 3130, 3342, 3495, 3866, 4344, 4353, 4451, 4556, 4629, 5121, 5476, 5499, 5526, 5553, 5586], 'comprised,': [63], 'as': [64, 158, 865, 1584, 2368, 3189, 3410, 3487, 3816, 4114, 4246, 4261, 4436, 4636, 4638, 4722, 5293, 5295, 5453], 'other': [65, 2439, 3081, 3872, 3875, 4580, 5378], 'receptors,': [67], 'multiple': [69, 512, 935, 3829, 4634, 4900], 'components,': [70], 'in': [71, 85, 101, 152, 182, 204, 249, 382, 388, 404, 410, 432, 614, 668, 731, 859, 921, 991, 1147, 1156, 1161, 1291, 1436, 1452, 1575, 1599, 2099, 2211, 2351, 2372, 2598, 2939, 2978, 3006, 3076, 3110, 3121, 3179, 3221, 3225, 3256, 3308, 3424, 3618, 3824, 4385, 4439, 4447, 4548, 4622, 4736, 4749, 4760, 4789, 4793, 4797, 4800, 4849, 4861, 5134, 5167, 5177, 5338, 5403, 5418, 5503, 5558, 5577, 5592, 5629, 5649], 'this': [72, 2201, 3114, 4152, 4343, 4627, 5135, 5168], 'case': [73, 4335], 'designated': [74, 192], 'IFNAR1': [75, 610, 822, 1448, 2104, 2163, 2209, 2234, 2255, 2373, 2494, 3494, 3523, 3641, 4065, 4399, 4474, 4561, 4565, 5117, 5512], 'IFNAR2.': [77], 'However': [78, 5597], 'it': [79, 180, 464, 4453, 5410, 5415, 5505], 'unique': [81, 1037, 1125], 'among': [82, 5555], 'receptors': [84, 108, 176, 355, 1275, 1827, 2975, 3003, 3481, 4244, 4857, 5557], 'the': [86, 115, 172, 185, 210, 285, 293, 348, 351, 399, 466, 491, 494, 517, 521, 721, 756, 829, 900, 910, 1016, 1024, 1028, 1093, 1101, 1187, 1292, 1354, 1375, 1437, 1453, 1488, 1498, 1528, 1546, 1576, 1620, 1663, 1755, 1763, 2041, 2058, 2093, 2111, 2158, 2168, 2206, 2230, 2238, 2241, 2340, 2357, 2369, 2444, 2504, 2508, 2593, 2684, 2776, 2779, 2854, 2931, 3011, 3122, 3127, 3170, 3285, 3301, 3335, 3343, 3415, 3421, 3553, 3726, 3731, 3809, 3869, 3939, 4057, 4158, 4169, 4209, 4214, 4268, 4281, 4334, 4339, 4345, 4359, 4448, 4586, 4594, 4603, 4606, 4703, 4737, 4801, 5116, 5130, 5398, 5423, 5427, 5458, 5531, 5543, 5578, 5581, 5593, 5631, 5634, 5646, 5663, 5675], 'number': [87, 1293, 2437, 3970, 4863], 'cognate': [89], 'ligands,': [90], 'including': [91, 3874, 3975], '13': [92], 'IFNα': [93, 1208, 3234, 3686, 4391, 4635, 5128], 'subtypes,': [94], 'β,': [95, 938], 'ω,': [96], '∊,': [97, 939], 'κ,': [98], 'others': [100, 2491], 'some': [102, 1157, 4557], 'species.': [103], 'are': [109, 146, 723, 753, 1004, 1137, 2354, 2784, 2840, 2976, 3004, 3288, 4154, 5104, 5124, 5607, 5658], 'distinct': [110, 4759], 'from': [111, 712, 755, 1083, 1154, 1384, 1754, 2259, 2487, 2894, 2905, 3228], 'those': [112], 'required': [113], 'for': [114, 446, 903, 1500, 1627, 1823, 2051, 2110, 2497, 2503, 3113, 3169, 4157, 4458, 4473, 4631, 4707, 5478, 5588], '(IFNGR1': [119], 'IFNGR2)': [121], 'III': [124], 'IFNs': [125, 165, 422, 907, 1428, 2046, 2937, 3079, 5473, 5541, 5619, 5670], '(IFNLR': [126], 'IL10Rβ).': [128], 'Nevertheless,': [129, 3116], 'genes': [130, 510, 945, 4852, 5120, 5590], 'encoding': [131, 750, 998, 1035, 4853], 'a': [132, 153, 244, 299, 305, 307, 312, 501, 805, 809, 815, 866, 926, 1033, 1084, 1107, 1110, 1115, 1120, 1212, 1343, 1347, 1361, 1541, 1949, 2107, 2165, 2376, 3061, 3119, 3166, 3407, 3425, 3561, 3637, 3739, 3969, 4067, 4110, 4194, 4258, 4275, 4396, 4455, 4599, 4723, 4733, 4742, 4862, 5383, 5445, 5454, 5463, 5517, 5527, 5535], 'component': [133, 4628], 'each': [135, 1586, 2052, 2944, 3826], 'receptor,': [139, 190, 3461], 'namely': [140], 'IFNAR1,': [141, 193], 'IFNAR2,': [142, 2106, 4207, 4563], 'IFNGR2,': [143], 'IL10Rβ,': [145], 'located': [147], 'on': [148, 1027, 1141, 2040, 2054, 2090, 2102, 2254, 2356, 2853, 3474, 3552, 4355, 4609, 5522], 'human': [149, 200, 217, 245, 821, 933, 2113, 5404], 'chromosome': [150], '21q22.1': [151], 'gene': [156, 201, 256, 758, 4739], 'cluster,': [157], 'typical': [159, 3462], 'functionally': [161], 'related': [162, 5567], 'genes.': [163], 'Although': [164, 3165, 4441, 5397], 'were': [166, 4758, 4791], 'identified': [167, 613, 715, 990, 1197, 2367, 3737], '50': [168], 'years': [169, 178], 'ago': [170], 'existence': [173], '10': [177, 1459, 3141], 'later,': [179], 'was': [181, 194, 197, 239, 281, 3250, 3736, 4201], '1990': [183], 'when': [184, 3616, 4267], 'first': [186, 241], 'now': [191], 'cloned.': [195], 'This': [196, 393, 852, 1096, 1336, 2151, 4105, 5498, 5572, 5612], 'achieved': [198, 240, 3867], 'utilizing': [199], 'libraries': [202], 'expressed': [203, 669, 4354], 'murine': [205, 1148, 1577], 'cells': [206, 471, 714, 3620, 4552, 5123, 5433], 'rescue': [208], 'definitive,': [211], 'species': [212, 5544], 'specific': [213], 'antiviral': [214, 830, 3254, 5532, 5595], 'activity': [215, 248, 2984, 3255, 3423, 3470, 5343, 5351, 5533], 'IFNα8': [218], '(1Uze': [219], 'G.': [220, 222, 316, 543, 682, 771, 1466, 1642, 1693, 1695, 1730, 2019, 2322, 2385, 2516, 2543, 2562, 2577, 2612, 2654, 2669, 2705, 2811, 2826, 2867, 2916, 2956, 4653, 4923, 4972, 5012, 5189], 'Lutfalla': [221, 1694], 'Gresser': [223], 'I.': [224, 587, 955, 1058, 1173, 1225, 1636, 1780, 1966, 2537, 2734, 3028, 3203, 3703, 4409, 4492, 4655, 4657, 5145], 'Cell.': [225, 268, 530, 842, 3510, 3577, 3606, 3795, 3991, 5486], '1990;': [226, 1400, 1518, 1559, 1680, 1837], '60:': [227, 4996], '225-234Abstract': [228], 'Full': [229, 272, 534, 596, 598, 651, 653, 1067, 1069, 1328, 1738, 1740, 2027, 2029, 2620, 2622, 2713, 2715, 2875, 2877, 3666, 3668, 3712, 3714, 3766, 3768, 3851, 3853, 4095, 4097, 4183, 4185, 4933, 4935, 5490], 'Text': [230, 273, 535, 597, 599, 652, 654, 1068, 1070, 1329, 1739, 1741, 2028, 2030, 2621, 2623, 2714, 2716, 2876, 2878, 3667, 3669, 3713, 3715, 3767, 3769, 3852, 3854, 4096, 4098, 4184, 4186, 4934, 4936, 5491], 'PDF': [231, 274, 536, 600, 655, 1071, 1330, 1742, 2031, 2624, 2717, 2879, 3670, 3716, 3770, 3855, 4099, 4187, 4937, 5492], 'PubMed': [232, 275, 340, 458, 485, 537, 567, 601, 630, 656, 706, 795, 847, 962, 980, 1072, 1180, 1232, 1250, 1266, 1331, 1403, 1477, 1521, 1562, 1651, 1683, 1705, 1743, 1791, 1816, 1840, 1879, 1908, 1937, 1977, 2000, 2032, 2084, 2146, 2195, 2286, 2305, 2431, 2479, 2527, 2552, 2569, 2584, 2625, 2644, 2661, 2676, 2718, 2745, 2768, 2818, 2833, 2880, 2923, 2967, 2996, 3035, 3051, 3100, 3160, 3210, 3276, 3368, 3397, 3448, 3515, 3543, 3582, 3611, 3629, 3671, 3717, 3771, 3800, 3856, 3889, 3921, 3996, 4020, 4050, 4100, 4145, 4188, 4237, 4299, 4328, 4377, 4416, 4499, 4517, 4533, 4668, 4691, 4831, 4893, 4938, 4965, 4998, 5050, 5099, 5154, 5227, 5254, 5279, 5324, 5372, 5493], 'Scopus': [233, 276, 341, 459, 486, 538, 568, 602, 631, 657, 707, 796, 848, 963, 981, 1073, 1181, 1233, 1251, 1332, 1404, 1478, 1522, 1563, 1652, 1684, 1706, 1744, 1792, 1817, 1841, 1880, 1909, 1938, 1978, 2001, 2033, 2085, 2147, 2196, 2287, 2306, 2432, 2480, 2528, 2553, 2570, 2585, 2626, 2645, 2662, 2677, 2719, 2746, 2769, 2819, 2834, 2881, 2924, 2968, 2997, 3036, 3052, 3101, 3161, 3211, 3277, 3369, 3398, 3449, 3516, 3544, 3583, 3612, 3630, 3672, 3718, 3772, 3801, 3857, 3890, 3922, 4021, 4051, 4101, 4146, 4189, 4238, 4300, 4329, 4378, 4417, 4500, 4518, 4669, 4692, 4832, 4894, 4939, 4966, 4999, 5051, 5100, 5155, 5228, 5255, 5280, 5325, 5373, 5494], '(513)': [234], 'Google': [235, 278, 343, 461, 488, 540, 570, 604, 633, 659, 709, 798, 850, 892, 965, 983, 1075, 1183, 1235, 1253, 1267, 1334, 1406, 1480, 1524, 1565, 1614, 1654, 1686, 1708, 1746, 1794, 1819, 1843, 1882, 1911, 1940, 1980, 2003, 2035, 2087, 2149, 2198, 2226, 2289, 2308, 2335, 2398, 2434, 2482, 2530, 2555, 2572, 2587, 2628, 2647, 2664, 2679, 2721, 2748, 2771, 2821, 2836, 2883, 2926, 2970, 2999, 3038, 3054, 3103, 3163, 3213, 3279, 3371, 3400, 3451, 3518, 3546, 3585, 3614, 3632, 3674, 3720, 3774, 3803, 3859, 3892, 3924, 3997, 4023, 4053, 4103, 4148, 4191, 4240, 4302, 4331, 4380, 4419, 4502, 4520, 4534, 4671, 4694, 4834, 4896, 4941, 4968, 5001, 5053, 5102, 5157, 5230, 5257, 5282, 5327, 5375, 5496], 'Scholar).': [236, 279, 489, 605, 660, 851, 984, 1076, 1184, 1268, 1335, 1407, 1481, 1525, 1566, 1615, 1655, 1709, 1820, 1941, 2150, 2199, 2435, 2588, 2837, 2884, 2927, 2971, 3000, 3055, 3164, 3214, 3280, 3401, 3452, 3547, 3586, 3633, 3721, 3775, 3804, 3860, 3893, 3925, 4104, 4149, 4192, 4241, 4332, 4381, 4420, 4695, 4835, 5158, 5283, 5328, 5376, 5497], 'IFNAR2': [237, 294, 748, 1018, 1431, 1485, 2596, 2780, 2857, 2897, 3002, 3063, 3072, 3172, 3249, 3785, 4482, 4570, 5119, 5290, 5402, 5514], 'cloning': [238, 1279], 'by': [242, 255, 759, 1006, 1099, 1207, 2375, 2842, 3068, 3073, 3133, 3137, 3139, 3334, 3349, 3868, 4108, 4257, 4579, 5106, 5300, 5561, 5609, 5674], 'identifying': [243], 'binding': [247, 1295, 1299, 1304, 1310, 1339, 1350, 1358, 1371, 1600, 1622, 2101, 2212, 2250, 2353, 2406, 2454, 2686, 2782, 2805, 2941, 3550, 3735, 4109], 'urine,': [250, 3008], 'peptide': [251], 'sequencing,': [252], 'then': [254], 'library': [257], 'screening': [258], 'with': [259, 359, 855, 934, 1123, 1288, 1342, 1381, 1432, 1449, 1540, 1666, 1721, 1852, 2313, 2601, 2902, 2943, 3497, 3640, 3677, 3784, 3968, 4206, 4274, 4564, 4582, 4619, 4732, 5140, 5336], 'derived': [260], 'oligonucleotides': [261], '(2Novick': [262, 524], 'D.': [263, 322, 525, 549, 688, 777, 836, 3041, 3090, 4034, 4129, 4815, 4885], 'Cohen': [264, 526, 3042], 'B.': [265, 527, 583, 834, 1054, 3043, 3699, 4770, 4913], 'Rubinstein': [266, 528, 839, 3044], 'M.': [267, 529, 581, 624, 840, 1052, 1464, 1634, 1889, 1891, 1895, 2065, 2067, 2071, 2296, 2514, 2535, 2558, 2635, 2650, 2807, 2954, 3045, 3313, 3316, 3376, 3697, 3749, 3985, 4307, 4686, 4773, 4775, 4907, 4921, 4988, 5040, 5074, 5076, 5080, 5217, 5270, 5315, 5363], '1994;': [269, 531, 627, 1611, 1788, 1974, 2223, 2742, 4688], '77:': [270, 532], '391-400Abstract': [271, 533], '(585)': [277, 539], 'It': [280, 2928], 'subsequently': [282], 'discovered': [283, 375], 'that': [284, 303, 374, 427, 514, 720, 861, 1113, 1201, 1282, 1366, 1424, 2043, 2154, 2229, 2493, 2930, 3060, 3184, 3297, 3808, 4387, 4429, 4554, 4584, 4626, 4740, 5468, 5504, 5601, 5653], 'original': [286], 'cDNA': [287, 679], 'encoded': [288, 298], 'only': [289, 716, 730, 5430], 'one': [290, 717, 1588], 'isoform': [291, 302, 314, 1097, 3173], 'gene,': [295], 'which': [296, 916, 1496, 1748, 1947, 3341, 3520, 3825, 4075, 5475, 5585, 5654], 'also': [297, 2448, 2802, 3065, 3405, 3521, 3588, 3781, 3966, 4155, 4729], 'long': [300, 806], 'transmembrane': [301, 309, 811, 1132, 3071, 4277, 4360, 4479], 'transduced': [304], 'signal,': [306], 'truncated': [308], 'isoform,': [310, 718], 'soluble/secreted': [313], '(3Lutfalla': [315, 681, 770], 'Holland': [317, 544, 576, 683, 772, 1047, 3692, 4644], 'S.J.': [318, 545, 684, 773], 'Cinato': [319, 546, 685, 774], 'E.': [320, 547, 620, 622, 686, 775, 881, 1462, 2512, 2952, 3655, 3745, 4909, 5018, 5195, 5260, 5268, 5305, 5313, 5353, 5361], 'Monneron': [321, 548, 687, 776], 'Reboul': [323, 550, 689, 778], 'J.': [324, 336, 479, 551, 563, 590, 645, 690, 702, 741, 779, 791, 887, 1061, 1262, 1468, 1470, 1471, 1604, 1609, 1640, 1644, 1645, 1698, 1732, 1922, 2021, 2131, 2180, 2216, 2221, 2271, 2298, 2299, 2326, 2389, 2416, 2464, 2518, 2520, 2521, 2541, 2545, 2546, 2563, 2575, 2578, 2614, 2637, 2638, 2655, 2667, 2670, 2707, 2812, 2824, 2827, 2869, 2914, 2917, 2958, 2960, 2961, 2992, 3150, 3153, 3320, 3358, 3361, 3386, 3441, 3531, 3539, 3660, 3706, 3755, 3760, 3842, 3845, 4016, 4089, 4177, 4233, 4289, 4292, 4317, 4529, 4682, 4768, 4777, 4782, 4879, 4928, 4949, 4955], 'Rogers': [325, 552, 691, 780], 'N.C.': [326, 553, 585, 692, 781, 1056, 3701], 'Smith': [327, 554, 693, 782, 5484], 'J.M.': [328, 555, 694, 783], 'Stark': [329, 556, 695, 784, 3603, 3792], 'G.R.': [330, 557, 696, 785, 3604, 3793], 'Gardiner': [331, 558, 697, 786], 'K.': [332, 559, 698, 787, 1770, 1956, 2724, 3432, 3502, 3569, 4012, 4038, 4133, 4229, 4819, 5016, 5024, 5030, 5034, 5038, 5193, 5201, 5207, 5211, 5215, 5264, 5274, 5309, 5319, 5357, 5367], 'Mogensen': [333, 560, 699, 788, 1696, 2559, 2651, 2808], 'K.E.': [334, 561, 700, 789, 1697, 2560, 2652, 2809], 'EMBO': [335, 562, 701, 790, 4015, 4232], '1995;': [337, 564, 703, 792, 844, 1702, 1813, 1876, 1997, 2765, 4665, 5487], '14:': [338, 565, 704, 793, 978, 1248, 4515], '5100-5108Crossref': [339, 566, 705, 794], '(227)': [342, 569, 708, 797, 4052, 4147, 4833], 'Scholar)': [344, 799, 893, 1687, 1795, 2036, 2088, 2227, 2309, 2336, 2399, 2483, 2680, 2772, 3615, 4535, 5103], '(Fig.': [345, 800, 894, 1129, 1592, 2037, 2337, 2484, 2681, 2773, 2858, 2911, 3242, 4263], '1A).': [346, 1130], 'Subsequently,': [347], 'functions': [349], 'have': [356, 384, 611, 1280, 1421, 1848, 2047, 2365, 2447, 2591, 3182, 3406, 4383, 4624, 4728, 4858, 5163, 5174, 5380, 5443], 'been': [357, 385, 612, 899, 989, 1712, 2120, 2257, 2366, 2449, 3177, 3558, 4859, 5138, 5165, 5175, 5412, 5575, 5626], 'elucidated': [358], 'respect': [360], 'to': [361, 417, 516, 909, 932, 1106, 1159, 1277, 1387, 1418, 1430, 1442, 1447, 1458, 1487, 1545, 1583, 1618, 1662, 1714, 1751, 2204, 2403, 2451, 2844, 2891, 3078, 3252, 3291, 3479, 3560, 3738, 3957, 4055, 4116, 4203, 4541, 4576, 4597, 4633, 4745, 4752, 4845, 4899, 5127, 5394, 5511, 5660], 'ligand': [362, 1370, 1380, 1621, 2059, 2100, 2156, 2170, 2246, 2352, 2599, 2685, 2781, 4272], 'interaction,': [363], 'mechanisms': [364, 379], 'transduction,': [367], 'biological': [369, 425, 504, 2949, 4255, 5622, 5665], 'responses.': [370, 5623], 'pioneering': [372], 'studies': [373, 905, 1410, 2590, 3058, 4574, 5379, 5425, 5642], 'IFNARs': [376, 403, 3936, 3965], 'their': [378, 1278, 4750, 4761, 4794], 'actions': [381, 3327], 'vitro': [383, 3057, 3180, 3257, 4386], 'largely': [386, 2692, 2849], 'validated': [387, 4578], 'vivo': [389, 3111], 'using': [390, 1193, 1411, 4424], 'genetargeted': [391], 'mice.': [392], 'body': [394, 2979], 'work': [396], 'has': [397, 898, 925, 988, 1367, 1711, 1749, 2006, 2119, 2256, 3174, 3557, 3828, 4701, 5137, 5411, 5506, 5516, 5574, 5625], 'highlighted': [398], 'important': [400], 'roles': [401], 'mediating': [405, 5559], 'responses': [409, 872, 4632, 4720], 'hemopoiesis': [411, 4798], 'innate': [413], 'acquired': [415], 'immunity': [416], 'infection': [418, 3942], 'cancer.': [420], 'However,': [421, 661, 1942, 2200, 5638], 'elicit': [423, 5656], 'many': [424, 447, 5178, 5602], 'effects': [426, 4256], 'can': [428, 917, 3064, 3186, 3217, 3232, 3304, 3937, 3955, 4252, 4389, 5671], 'even': [429, 3962], 'be': [430, 2343, 2892, 3066, 3332, 3782, 4577, 4846, 5407, 5672], 'opposite': [431], 'different': [433, 2893, 2940, 4549, 4610, 5565, 5664], 'cell': [434, 448, 615, 734, 1284, 3524, 4469, 4595, 4611, 4765], 'types.': [435], 'For': [436], 'example,': [437], 'inhibits': [441], 'proliferation': [442], 'proapoptotic': [445], 'types': [449, 1285, 1308, 4612], '(4Platanias': [450, 3621, 3881, 3913], 'L.C.': [451, 3622, 3751, 3882, 3914], 'Nat.': [452, 3623, 3883, 3915, 4045, 4140, 4826], 'Rev.': [453, 481, 3624, 3884, 3916], 'Immunol.': [454, 480, 1323, 1610, 2222, 3625, 3885, 3917, 4046, 4141, 4827], '2005;': [455, 889, 1648, 2549, 3157, 3365, 3626, 3886, 3918, 4296, 4930], '5:': [456, 2994, 3627, 3887, 3919], '375-386Crossref': [457, 3628, 3888, 3920], '(2372)': [460, 3631, 3891, 3923], 'Scholar),': [462, 1747, 1844, 2004, 3104, 3519, 3675, 4054, 4897, 4942, 4969, 5002], 'yet': [463, 3176], 'prolongs': [465], 'survival': [467, 4708], 'memory': [469], 'T': [470, 4717, 4764], '(5Tough': [472], 'D.F.': [473], 'Sun': [474], 'S.': [475, 644, 838, 878, 951, 1169, 1221, 1322, 1398, 1516, 1557, 1678, 1835, 1899, 2075, 2294, 2633, 3024, 3152, 3199, 3271, 3360, 3392, 3537, 3600, 3789, 4291, 4323, 4370, 4405, 4488, 4663, 4680, 4779, 4945, 4957, 5042, 5064, 5070, 5072, 5094, 5219, 5243, 5262, 5266, 5307, 5311, 5355, 5359], 'Zhang': [476, 4013, 4031, 4126, 4230, 4812, 4882, 5057], 'X.': [477, 953, 1171, 1223, 1920, 2129, 2178, 2269, 2414, 2462, 3026, 3201, 3598, 3787, 4407, 4490], 'Sprent': [478, 3385, 4316], '1999;': [482, 2581, 2673, 2830, 2920, 3993, 5276, 5321, 5369], '170:': [483], '39-47Crossref': [484], '(93)': [487], 'Understanding': [490], 'function': [492, 3168], 'IFNAR': [495, 509, 1413, 1482, 2945, 3864, 4589, 4607, 5107, 5435, 5551, 5610], 'complex': [496, 1629, 2118, 4283, 5552, 5621], 'will': [497, 5406], 'elucidate': [498, 5661], 'how': [499, 5618, 5662], 'such': [500, 3486, 3815, 4113, 4245], 'diversity': [502, 3862, 3931, 5613], 'outcomes': [505], 'generated.': [507], 'encode': [511, 804, 5462], 'isoforms': [513, 752, 1000, 4480], 'contribute': [515], 'potential': [518, 5647], 'complexity': [519], 'functional': [522], 'Scholar,': [541, 571, 634, 966, 1236, 1254, 1883, 1912, 1981, 2290, 2531, 2556, 2573, 2629, 2648, 2665, 2722, 2749, 2822, 3039, 3372, 3998, 4024, 4303, 4503, 4521, 4672, 5054, 5231, 5258], '3Lutfalla': [542], '6Owczarek': [572], 'C.M.': [573, 638, 949, 974, 1044, 1167, 1219, 1244, 1260, 3022, 3197, 3689, 4403, 4486, 4511, 4527], 'Hwang': [574, 1045, 3690], 'S.Y.': [575, 1046, 3535, 3691, 4010, 4088, 4176, 4227, 4641], 'K.A.': [577, 1048, 3693, 4645], 'Gulluyan': [578, 1049, 3694], 'L.M.': [579, 1050, 3659, 3695], 'Tavaria': [580, 1051, 3696], 'Weaver': [582, 1053, 3698], 'Reich': [584, 1055, 3700], 'Kola': [586, 954, 1057, 1172, 1224, 3027, 3202, 3702, 4408, 4491, 4656], 'Hertzog': [588, 956, 971, 1059, 1174, 1226, 1241, 1257, 3029, 3204, 3704, 4043, 4138, 4410, 4493, 4508, 4524, 4642, 4824, 5146], 'P.J.': [589, 957, 972, 1060, 1175, 1227, 1242, 1258, 1809, 1872, 1993, 2761, 3030, 3148, 3205, 3356, 3705, 4044, 4139, 4287, 4411, 4494, 4509, 4525, 4643, 4825, 5147], 'Biol.': [591, 646, 843, 1062, 1473, 1647, 2301, 2523, 2548, 2565, 2580, 2640, 2657, 2672, 2814, 2829, 2919, 2963, 3511, 3578, 3607, 3661, 3707, 3761, 3796, 3846, 3992, 4090, 4178], 'Chem.': [592, 647, 1063, 3662, 3708, 3762, 3847, 4091, 4179], '1997;': [593, 1064, 3608, 3709, 3763, 3797, 5151], '272:': [594, 1065, 3710, 3764], '23865-23870Abstract': [595, 1066, 3711], '(52)': [603, 1074, 3719], 'Two': [606], 'splice': [607, 666, 1025], 'variants': [608, 667], 'lines': [616, 4470], '(7Abramovich': [617], 'C.': [618, 874, 1887, 1893, 1914, 2063, 2069, 2123, 2172, 2263, 2408, 2456, 3315, 4772, 4873, 4919, 4953, 4978], 'Ratovitski': [619], 'Lundgren': [621], 'Revel': [623], 'FEBS': [625, 3046], 'Lett.': [626, 3047], '338:': [628], '295-300Crossref': [629], '(29)': [632, 3278], '8Cook': [635], 'J.R.': [636], 'Cleary': [637], 'Mariano': [639], 'T.M.': [640], 'Izotova': [641], 'L.': [642, 1885, 2061, 3647, 3653, 4883, 4903, 5058], 'Pestka': [643, 1321], '1996;': [648, 3512, 3579, 3663], '271:': [649, 3664], '13448-13453Abstract': [650], '(56)': [658], 'subsequent': [662], 'bioinformatic': [663], 'analyses': [664, 711, 1144, 1302], 'sequence': [670, 1690, 2932], 'tag': [671], '(EST)': [672], 'data': [673, 3806, 5599], 'bases': [674], 'rapid': [676], 'amplification': [677], 'ends': [680], 'Scholar′-RACE)': [710], 'normal': [713, 3222], 'suggesting': [719, 3296], 'former': [722], 'either': [724, 3188], 'artifacts': [725], 'or': [726, 1356, 1363, 2244, 3192, 3235, 3325, 3952, 4392, 4867, 5420, 5513], 'aberrant': [727, 5131, 5141], 'transcripts': [728, 749, 803, 995, 1136, 4472], 'found': [729, 2355, 5382], 'particular': [732], 'tumor': [733, 3427], 'lines.': [735], '3S.': [736], 'A.': [737, 883, 1399, 1517, 1558, 1679, 1782, 1836, 1903, 1968, 2079, 2736, 3093, 3272, 3311, 3393, 3649, 4324, 4664, 4881, 4915, 4925, 4959, 4980, 4986, 5066, 5095, 5247, 5483], 'Samarajiwa': [738], 'P.': [740, 1632, 1926, 1932, 2135, 2141, 2184, 2190, 2275, 2281, 2292, 2318, 2381, 2420, 2426, 2468, 2474, 2533, 2631, 3319, 3743, 3757], 'Hertzog,': [742, 3321, 4769], 'unpublished': [743, 3322, 4784], 'data.': [744, 3323, 4785], 'In': [745, 3056, 3244, 4333, 5109], 'contrast,': [746], 'four': [747, 1580], 'three': [751, 1198, 1846, 2358, 2785], 'generated': [754, 1005, 1082, 3067, 3131, 3934, 4730], 'same': [757], 'exon': [760, 1029, 1103], 'skipping,': [761], 'alternative': [762, 3134, 4460, 5605], 'splicing,': [763], 'differential': [765, 1007, 2505, 4558, 4842], 'usage': [766], 'polyadenylation': [768], 'sites': [769, 1296, 1311], '1A)': [801], 'These': [802, 2838, 3805, 3894, 4573], 'trans-membrane': [807], 'IFNAR2c,': [808, 824], 'short': [810], 'IFNAR2b': [812, 862, 986], 'chain,': [813, 4342], 'soluble': [816, 999, 1121, 1134, 3062, 3128, 3171, 3248, 3286, 3329, 4269, 4477, 5401, 5448, 5464], 'sIFNAR2a': [817, 3185, 3231, 3302, 3413, 4388, 4427, 4433, 5162, 5173, 5296, 5334, 5387], 'chain.': [818], 'Transfection': [819], 'but': [825, 993, 3105, 4358, 4757, 5440, 5515, 5566], 'not': [826, 3175, 5164, 5381], 'IFNAR2b,': [827], 'reconstituted': [828], 'response': [832, 3077, 5133, 5393], '(9Cohen': [833], 'Novick': [835], 'Barak': [837], 'Mol.': [841, 1472, 1646, 2300, 2522, 2547, 2564, 2579, 2639, 2656, 2671, 2813, 2828, 2918, 2962, 3509, 3576, 3605, 3794, 3990, 5149], '15:': [845, 1703], '4208-4214Crossref': [846], '(152)': [849], 'consistent': [854, 1341, 3676], 'data,': [856], 'at': [857, 4593], 'least': [858], 'sarcomas,': [860], 'may': [863, 2235, 2342, 3331, 3780, 3818, 4106, 4434, 5616], 'act': [864, 3187, 4435], 'dominant': [867], 'negative': [868, 1213, 3972, 4111], 'regulator': [869, 4112], '(10Gazziola': [873], 'Cordani': [875], 'N.': [876], 'Carta': [877], 'De': [879], 'Lorenzo': [880], 'Colombatti': [882], 'Perris': [884], 'R.': [885, 1728, 2017, 2324, 2387, 2610, 2703, 2865, 2990, 3438, 4028, 4123, 4809], 'Int.': [886], 'Oncol.': [888], '26:': [890], '129-140PubMed': [891], '1B).': [895, 3243, 4264], 'mouse': [897, 924], 'primary': [901, 1357, 3226], 'model': [902, 1715, 2109, 2152, 3428], 'pathophysiological': [904], 'due': [908], 'capability': [911], 'generating': [913], 'knockout': [914], 'mice,': [915, 3230], 'demonstrate': [918, 3059], 'cause-and-effect': [919], 'associations': [920], 'vivo.': [922, 3309], 'comparable': [927], 'system': [931, 3125, 4450, 5573], 'ligands': [936, 2510], '(α,': [937], 'etc.)': [940], 'Ifnar1': [942, 4623, 4706, 4746], 'Ifnar2': [944, 1094, 1135, 1192, 4738], '(11Hardy': [946, 1164, 1216, 3019, 3194, 4400, 4483], 'M.P.': [947, 968, 1165, 1217, 1238, 1256, 3020, 3195, 3374, 4305, 4401, 4484, 4505, 4523], 'Owczarek': [948, 973, 1166, 1218, 1243, 1259, 3021, 3196, 4402, 4485, 4510, 4526], 'Trajanovska': [950, 1168, 1220, 3023, 3198, 4404, 4487], 'Liu': [952, 1170, 1222, 3025, 3200, 4406, 4489], 'Blood.': [958, 1176, 1228, 3031, 3206, 4412, 4495], '2001;': [959, 1177, 1229, 3032, 3207, 3273, 4413, 4496], '97:': [960, 1178, 1230, 3033, 3208, 4414, 4497], '473-482Crossref': [961, 1179, 1231, 3034, 3209, 4415, 4498], '(91)': [964, 1182, 1234, 3037, 3212, 4418, 4501], '12Hardy': [967, 1237, 4504], 'Sanij': [969, 1239, 4506], 'E.P.': [970, 1240, 4507], 'Mamm.': [975, 1245, 4512], 'Genome.': [976, 1246, 4513], '2003;': [977, 1247, 1735, 2024, 2617, 2710, 2872, 4514, 4890, 5251], '105-118Crossref': [979, 1249, 4516], '(15)': [982, 1252, 4519], 'No': [985], 'chain': [987, 1351, 1365, 1383, 2946, 4279], 'mouse,': [992], 'two': [994, 1307, 1760, 1849, 1857], 'capable': [996, 1117], '(sIfnar2a': [1001], 'sIfnar2a′)': [1003], 'splicing.': [1008], 'more': [1010, 3289, 4442, 4567, 4571, 5125, 5301, 5562, 5603, 5639], 'abundant': [1011], '1.5-kb': [1012], 'sIfnar2a': [1013], 'transcript': [1014, 1034, 1080, 1085, 1116, 5291], 'encodes': [1015], 'complete': [1017], 'domain': [1020, 1549, 1591, 2161, 2783, 3728], 'reads': [1022], 'through': [1023, 3935, 4398], 'site': [1026, 2251, 2687, 3551, 3732], '7–7′': [1030], 'boundary': [1031], 'producing': [1032, 1119], '12': [1036], 'mostly': [1039, 1435, 1451, 5417], 'hydrophobic': [1040, 2695, 2851], 'C-terminal': [1041, 1126], 'residues': [1042, 1597, 2207, 2371, 2442, 2594, 2788, 2839, 2898, 3564], '(6Owczarek': [1043, 3688], 'sIfnar2a′': [1078], 'minor': [1079, 2903], 'missing': [1086], '128': [1087], 'nucleotides': [1088], 'after': [1089, 2245, 3490, 3685], 'codon': [1090, 1112], '236': [1091], 'cDNA.': [1095], 'originates': [1098], 'skipping': [1100], 'transmembrane-encoding': [1102], '8,': [1104], 'leading': [1105], 'frameshift': [1108], 'forming': [1109], 'stop': [1111], 'generates': [1114], '11': [1124], 'acids': [1128, 2097, 2697], 'differentially': [1138], 'regulated': [1139, 5673], 'based': [1140, 5521], 'Northern': [1142], 'blot': [1143], 'expression': [1146, 1206, 3526, 4366, 4547, 4559], 'tissues.': [1149], 'Ratios': [1150], 'tmIfnar2c:sIfnar2a': [1152], 'range': [1153, 1439, 1455, 5537], '>10:1': [1155], 'tissues': [1158, 1163, 4464, 4550], '∼1:1': [1160], 'hemopoietic': [1162], 'Analysis': [1185], '5′': [1188], 'flanking': [1189], 'region': [1190, 1215, 2446, 3556, 3562, 3741, 4070, 4153], 'promoter': [1194], 'reporter': [1195], 'constructs': [1196], 'regulatory': [1199, 1214, 3973], 'regions': [1200], 'confer': [1202], 'basal': [1203], 'expression,': [1204], 'inducible': [1205], '+': [1209], 'IFNγ,': [1210], '13Hardy': [1255, 4522], 'Biochem.': [1261, 3538, 4528, 5043, 5220], '2002;': [1263, 3848, 4374, 4530], '365:': [1264, 4531], '355-367Crossref': [1265, 4532], 'Structure-Function': [1269], 'Relationships—Studies': [1270], 'prior': [1276], 'indicated': [1281], 'most': [1283, 4356, 4468, 4710], 'bind': [1286, 1429, 1446, 3233, 4390, 4538], 'IFNs,': [1287], 'large': [1289], 'variation': [1290], '(200–10,000/cell)': [1297], 'affinities.': [1300], 'Scatchard': [1301], 'usually': [1305], 'identify': [1306], 'low': [1313, 1368, 5507], '(μm)': [1314], 'high': [1316, 1348, 1388, 3298, 4430], 'affinity': [1317, 1349, 1372, 1376, 1389], '(nm–pm)': [1318], '(14Langer': [1319], 'J.A.': [1320, 2320, 2383, 4651, 5481], 'Today.': [1324], '1988;': [1325], '9:': [1326], '393-400Abstract': [1327], '(191)': [1333], 'pattern': [1337], 'multicomponent': [1344], 'containing': [1346, 5115], '(often': [1352], 'called': [1353], 'α': [1355, 1382], 'chain)': [1359], 'β': [1362], 'signal-transducing': [1364, 3813], 'intrinsic': [1369, 3468], 'converts': [1374], 'interaction': [1378, 1720, 2049, 2886, 3639, 4210], 'moderate': [1385], '(nm)': [1386], '(pm)': [1390], '(15Bazan': [1391, 1509, 1550, 1671, 1828], 'J.F.': [1392, 1510, 1551, 1672, 1829, 3378, 4309, 4992], 'Proc.': [1393, 1511, 1552, 1673, 1830, 3266, 3387, 4318, 4658, 5089], 'Natl.': [1394, 1512, 1553, 1674, 1831, 3267, 3388, 4319, 4659, 5090], 'Acad.': [1395, 1513, 1554, 1675, 1832, 3268, 3389, 4320, 4660, 5091], 'Sci.': [1396, 1514, 1555, 1676, 1833, 3269, 3390, 4321, 4661, 5092], 'U.': [1397, 1515, 1556, 1677, 1834, 3270, 3391, 4322, 4662, 4674, 4676, 5060, 5093], '87:': [1401, 1519, 1560, 1681, 1838], '6934-6938Crossref': [1402, 1520, 1561, 1682, 1839], '(1881)': [1405, 1523, 1564, 1685, 1842], 'Recently,': [1408, 4193], 'elegant': [1409], 'recombinant': [1412], 'domains': [1415, 1539, 1851, 3811], '(ECDs)': [1416], 'tethered': [1417], 'lipid': [1419], 'membranes': [1420], 'clearly': [1422], 'demonstrated': [1423, 2450, 3183, 4384, 4625, 4702], 'various': [1425], 'Kd': [1433, 1450], 'values': [1434], 'nm': [1438], '(from': [1440, 1456], '0.1': [1441], '1000': [1443], 'nm)': [1444], 'μm': [1454], '0.05': [1457], 'μm)': [1460], '(16Jaks': [1461, 2511, 2951], 'Gavutis': [1463, 1633, 2295, 2513, 2534, 2634, 2953], 'Uze': [1465, 1641, 2515, 2542, 2561, 2653, 2810, 2955], 'Martal': [1467, 2517, 2957], 'Piehler': [1469, 1643, 2297, 2519, 2544, 2636, 2959], '2007;': [1474, 2524, 2964], '366:': [1475, 2525, 2965], '525-539Crossref': [1476, 2526, 2966], '(166)': [1479, 2529, 2969], 'Structures—IFNAR1': [1483], 'belong': [1486], 'class': [1489, 1529, 1764, 1824, 3464], '(hCR)': [1494], 'family,': [1495], 'includes': [1497], 'factor': [1505], '(TF),': [1506], 'IL10Rβ': [1508], 'Members': [1526], 'hCR': [1531, 1766, 1826], 'family': [1532], 'contain': [1533], 'tandem': [1534], '∼100': [1535], 'acid': [1537, 5509], '(aa)': [1538], 'predicted': [1542, 1822, 2258, 2841, 2890], 'topology': [1543, 1855], 'analogous': [1544], 'Ig': [1547], 'constant': [1548], 'ECD': [1568], 'huIFNAR1,': [1570], 'comprising': [1571], '409': [1572], 'aa': [1573], '(403': [1574], 'form)': [1578], 'contains': [1579, 1595, 4066], 'subdomains,': [1581], 'referred': [1582], 'SD1–SD4,': [1585], 'housing': [1587], 'fibronectin': [1589], '(FBN-III-like)': [1590], '2).': [1593, 2038, 2485, 2682, 2774], 'SD1': [1594], 'conserved': [1596, 1858, 1950, 2787, 4069], 'implicated': [1598, 2098, 2210, 4860], 'membrane': [1601, 2213], 'glycosphingolipids': [1602, 2214], '(17Ghislain': [1603, 2215], 'Lingwood': [1605, 2217], 'C.A.': [1606, 1807, 1870, 1991, 2218, 2759], 'Fish': [1607, 2219, 3744], 'E.N.': [1608, 2220], '153:': [1612, 2224], '3655-3663PubMed': [1613, 2225], 'SD1–SD3': [1616], 'appears': [1617, 2929], 'house': [1619], 'SD4': [1624], 'essential': [1626, 4156, 4630, 5477], 'ternary': [1628], 'formation': [1630, 3684], '(18Lamken': [1631], 'Peters': [1635, 2536], 'Van': [1637, 2538], 'der': [1638, 2539], 'Heyden': [1639, 2540], '350:': [1649, 2550], '476-488Crossref': [1650, 2551], '(48)': [1653, 2554], 'SD1-SD2': [1657], 'pair': [1658, 1665], 'structurally': [1660], 'similar': [1661, 4744], 'SD3-SD4': [1664], 'characteristic': [1667, 5594], 'disulfide-bonding': [1668], 'cysteine': [1669, 4198], 'pairs': [1670], '50%': [1689], 'homology': [1691, 5510], '(19Uze': [1692], 'Interferon': [1699, 3154, 3362, 3442, 4293], 'Cytokine': [1700, 2330, 2393, 3155, 3363, 3443, 4294], 'Res.': [1701, 3156, 3364, 3444, 4295, 5045, 5222], '3-26Crossref': [1704], '(232)': [1707], 'NMR': [1710, 2843], 'huIFNAR2': [1716, 2005, 2689], 'structure': [1717, 5632], 'its': [1719], 'huIFNα2': [1722], '(20Chill': [1723, 2012, 2605, 2698, 2860], 'J.H.': [1724, 2013, 2606, 2699, 2861, 3380, 4311], 'Quadt': [1725, 2014, 2607, 2700, 2862], 'S.R.': [1726, 2015, 2608, 2701, 2863], 'Levy': [1727, 2016, 2609, 2702, 2864], 'Schreiber': [1729, 2018, 2576, 2611, 2668, 2704, 2825, 2866, 2915, 4035, 4130, 4816], 'Anglister': [1731, 2020, 2613, 2706, 2868], 'Structure': [1733, 2022, 2615, 2708, 2870], '(Lond.).': [1734, 2023, 2616, 2709, 2871], '11:': [1736, 2025, 2333, 2396, 2618, 2711, 2873], '791-802Abstract': [1737, 2026, 2619, 2712, 2874], '(81)': [1745, 2034, 2627, 2720, 2882, 4895], 'similarities': [1750], 'differences': [1753, 2933, 4788], 'resolved': [1756], 'crystal': [1757], 'structures': [1758], 'members': [1761], 'group,': [1767], 'TF': [1768, 1944], '(21Harlos': [1769, 1955], 'Martin': [1771, 1957, 2725], 'D.M.': [1772, 1958, 2726], "O'Brien": [1773, 1959, 2727], 'D.P.': [1774, 1960, 2728], 'Jones': [1775, 1961, 2729], 'E.Y.': [1776, 1962, 2730], 'Stuart': [1777, 1963, 2731], 'D.I.': [1778, 1964, 2732], 'Polikarpov': [1779, 1965, 2733], 'Miller': [1781, 1898, 1967, 2074, 2735], 'Tuddenham': [1783, 1969, 2737], 'E.G.': [1784, 1970, 2738], 'Boys': [1785, 1971, 2739], 'C.W.': [1786, 1972, 2740], 'Nature.': [1787, 1812, 1875, 1973, 1996, 2741, 2764], '370:': [1789, 1975, 2743], '662-666Crossref': [1790, 1976, 2744], '(215)': [1793, 1979, 2747], 'IFNGR': [1797], '(22Walter': [1798, 1861], 'M.R.': [1799, 1862, 1983, 2751, 5086], 'Windsor': [1800, 1863, 1984, 2752], 'W.T.': [1801, 1864, 1985, 2753], 'Nagabhushan': [1802, 1865, 1986, 2754], 'T.L.': [1803, 1866, 1987, 2755], 'Lundell': [1804, 1867, 1988, 2756], 'D.J.': [1805, 1868, 1989, 2757, 4040, 4135, 4821], 'Lunn': [1806, 1869, 1990, 2758], 'Zauodny': [1808, 1871, 1992, 2760], 'Narula': [1810, 1873, 1994, 2762], 'S.K.': [1811, 1874, 1995, 2763], '376:': [1814, 1877, 1998, 2766], '230-235Crossref': [1815, 1878, 1999, 2767], '(360)': [1818, 1881, 2002, 2770], 'As': [1821], 'all': [1845, 5470], 'proteins': [1847, 3877, 3880, 5436], 'FBN-III': [1850, 2160, 2360], 'Ig-like': [1853], 'folding': [1854], 'disulfide': [1859], 'bonds': [1860], '23Runkel': [1884], 'deDios': [1886, 2062], 'Karpusas': [1888, 2064], 'Betzenhauser': [1890, 2066], 'Muldowney': [1892, 2068], 'Zafari': [1894, 2070], 'Benjamin': [1896, 2072], 'C.D.': [1897, 2073, 3384, 4315], 'Hochman': [1900, 2076], 'P.S.': [1901, 2077], 'Whitty': [1902, 2078, 4652], 'Biochemistry.': [1904, 1933, 2080, 2142, 2191, 2282, 2427, 2475], '2000;': [1905, 2081, 2332, 2395], '39:': [1906, 2082], '2538-2551Crossref': [1907, 2083], '(74)': [1910, 2086], '24Cajean-Feroldi': [1913], 'Nosal': [1915, 2124, 2173, 2264, 2409, 2457], 'F.': [1916, 1924, 2125, 2133, 2174, 2182, 2265, 2273, 2410, 2418, 2458, 2466, 3840, 4927, 4990], 'Nardeux': [1917, 2126, 2175, 2266, 2411, 2459], 'P.C.': [1918, 2127, 2176, 2267, 2412, 2460], 'Gallet': [1919, 2128, 2177, 2268, 2413, 2461], 'Guymarho': [1921, 2130, 2179, 2270, 2325, 2388, 2415, 2463], 'Baychelier': [1923, 2132, 2181, 2272, 2417, 2465], 'Sempe': [1925, 2134, 2183, 2274, 2419, 2467], 'Tovey': [1927, 2136, 2185, 2276, 2327, 2390, 2421, 2469], 'M.G.': [1928, 2137, 2186, 2277, 2328, 2391, 2422, 2470], 'Escary': [1929, 2138, 2187, 2278, 2423, 2471], 'J.L.': [1930, 2139, 2188, 2279, 2424, 2472, 4984, 5234, 5239], 'Eid': [1931, 2140, 2189, 2280, 2425, 2473], '2004;': [1934, 2143, 2192, 2283, 2302, 2428, 2476, 2641, 3097, 3445, 4092, 4180, 5047, 5224], '43:': [1935, 2144, 2193, 2284, 2429, 2477], '12498-12512Crossref': [1936, 2145, 2194, 2285, 2430, 2478], '(33)': [1939, 2148, 2197, 2288, 2433, 2481], 'unlike': [1943], 'show': [1948], 'interdomain': [1951, 2008], 'angle': [1952, 2009], '∼120°': [1954], '22Walter': [1982, 2750], 'an': [2007, 2048, 2314, 2846, 3190, 3239, 5500], 'approximating': [2010], '90°': [2011], 'Based': [2039], 'prediction': [2042, 2202], 'surfaces': [2050], 'opposing': [2055], 'sides': [2056], '(23Runkel': [2060], 'information': [2091], 'regarding': [2092], 'locations': [2094], 'both': [2103, 3015, 3132, 4476], 'three-dimensional': [2108], 'ligand-bound': [2112], 'proposed': [2121, 2402], '(24Cajean-Feroldi': [2122, 2171, 2262, 2407, 2455], 'predicts': [2153], 'upon': [2155], 'binding,': [2157], 'N-terminal': [2159], 'forms': [2164], 'lid': [2166], 'over': [2167, 3283], 'bound': [2169, 3412, 3589, 4271], 'fails': [2203], 'consider': [2205], 'so': [2228], 'N': [2231], 'terminus': [2232, 4063], 'fold': [2236], 'toward': [2237], 'membrane,': [2239], 'stabilizing': [2240], 'molecule': [2242, 3827], 'before': [2243], 'binding.': [2247], 'IFNAR-Ligand': [2248], 'Interaction—The': [2249], 'IFNα2': [2253, 2405, 2453, 2602, 2804], 'site-directed': [2260], 'mutagenesis': [2261], '25Lamken': [2291, 2630], 'Lata': [2293, 2632], '341:': [2303, 2642], '303-318Crossref': [2304, 2643], '(108)': [2307, 2646], 'epitope': [2311], 'mapping': [2312], 'anti-IFNAR1-neutralizing': [2315], 'antibody': [2316, 2379], '(26Eid': [2317, 2380], 'Langer': [2319, 2382], 'Bailly': [2321, 2384], 'Lejealle': [2323, 2386], 'Eur.': [2329, 2392], 'Netw.': [2331, 2394], '560-573PubMed': [2334, 2397], '2),': [2338], 'albeit': [2339], 'latter': [2341], 'inaccurate': [2344], 'because': [2345, 4351], 'steric': [2347], 'hindrances.': [2348], 'Residues': [2349, 2363, 4150], 'involved': [2350, 2597, 5591], 'membrane-distal': [2359], 'SD': [2361], 'domains.': [2362], '69VY70': [2364], 'key': [2370], 'recognition': [2374, 2506], 'neutralizing': [2377], 'monoclonal': [2378], 'thus': [2401, 3472, 4537], 'influence': [2404], 'A': [2436], 'surface-exposed,': [2440], 'aromatic': [2441], 'within': [2443, 4151], 'surrounding': [2445], 'aid': [2452], 'Studies': [2486], 'our': [2488, 4422], 'laboratory': [2489], 'suggest': [2492, 3807, 4428], 'necessary': [2496, 5587, 5659], 'signaling': [2498, 3220, 3307, 3865, 3896, 3954, 4082, 4119, 4340, 4350, 5143, 5560, 5583, 5636], 'possibly': [2501], 'responsible': [2502], '18Lamken': [2532], '27Lewerenz': [2557, 2649], '1998;': [2566, 2658, 2815], '282:': [2567, 2659, 2816], '585-599Crossref': [2568, 2660, 2817], '(77)': [2571, 2663, 2820], '28Piehler': [2574, 2666, 2823], '294:': [2582, 2674, 2831, 2921], '223-237Crossref': [2583, 2675, 2832, 2922], '(85)': [2586, 2678, 2835, 2925], 'Numerous': [2589], 'investigated': [2592], 'interactions': [2600, 3830], 'IFNβ': [2604, 2888, 3411, 3418, 4639], 'Notably,': [2683], 'composed': [2691], 'aliphatic': [2694, 2850], '21Harlos': [2723], 'Forming': [2775], 'core': [2777], 'highly': [2786, 4068], 'Thr44,': [2789, 2906], 'Met46,': [2790, 2907], 'Lys48,': [2792], 'whereas': [2793, 3224, 3950], 'residues,': [2794], 'His76,': [2795], 'Glu77,': [2796], 'Tyr81,': [2797], 'Trp100,': [2798, 2901], 'Ile103,': [2799], 'Asp106': [2801], 'facilitate': [2803], '(27Lewerenz': [2806], 'form': [2845, 3819, 4361, 5446], 'extensive': [2847], 'patch': [2852], 'surface': [2855, 3525], '2)': [2859, 2912], 'IFNα,': [2895], 'involving': [2896], 'Ile45': [2899], 'contributions': [2904], 'Ser47,': [2908], 'Ile103': [2910], '(28Piehler': [2913], 'between': [2934, 4211, 5385], 'result': [2938], 'affinities': [2942], 'consequent': [2948], 'activities': [2950, 5666], 'Soluble': [2972, 3001, 3215, 3402], 'IFNAR—Soluble': [2973], 'present': [2977, 3005], 'fluids': [2980], 'modulate': [2982], 'during': [2985, 4613, 5437], 'homeostasis': [2986, 4614], 'disease': [2988, 5405], '(29Fernandez-Botran': [2989], 'FASEB': [2991], '1991;': [2993], '2567-2574Crossref': [2995], '(258)': [2998], 'serum,': [3007], 'saliva,': [3009], 'peritoneal': [3012], 'fluid': [3013], 'humans': [3016], 'mice': [3018, 3282, 4425, 4700, 4731, 4748], '30Novick': [3040], '1992;': [3048], '314:': [3049], '445-448Crossref': [3050], '(73)': [3053, 3545], 'cleavage': [3069, 3138], 'intramembrane': [3074], 'proteases': [3075, 3144], 'stimuli': [3082], '(31Saleh': [3083], 'A.Z.': [3084, 3834], 'Fang': [3085], 'A.T.': [3086], 'Arch': [3087, 3835], 'A.E.': [3088, 3836], 'Neupane': [3089], 'El': [3091], 'Fiky': [3092], 'Krolewski': [3094, 3507, 3574, 3754, 3843, 4085, 4173], 'J.J.': [3095, 3508, 3575, 3844, 4086, 4174], 'Oncogene.': [3096], '23:': [3098], '7076-7086Crossref': [3099], '(45)': [3102], 'there': [3106, 3117, 4555], 'no': [3108], 'definitive': [3109, 3167], 'evidence': [3112, 4444], 'effect.': [3115], 'precedent': [3120], 'IL6': [3123, 4349], 'where': [3126, 5112], 'IL6Rα': [3129, 4337, 4363], 'splicing': [3135], 'ADAM': [3140], '17': [3143], '(32Jones': [3145, 3353, 4284], 'S.A.': [3146, 3354, 4285, 4368], 'Richards': [3147, 3355, 4286], 'Scheller': [3149, 3357, 4288], 'Rose-John': [3151, 3359, 4290, 4369], '25:': [3158, 3366, 4018, 4235, 4297], '241-253Crossref': [3159, 3367, 4298], '(216)': [3162, 3370, 4301], 'resolved,': [3178], 'experiments': [3181, 4423], 'agonist': [3191, 3326, 5419], 'antagonist': [3193, 5421], 'IFNAR2a': [3216, 3330, 3403], 'inhibit': [3218, 4117], 'cells,': [3223, 4357], 'thymocytes': [3227], 'Ifnar2–/–': [3229], '-β': [3236, 4393], 'generate': [3238, 5620], 'antiproliferative': [3240], 'another': [3245], 'study,': [3246], 'ovine': [3247], 'able': [3251], 'mediate': [3253, 4253], '(33Han': [3258], 'C.S.': [3259], 'Chen': [3260], 'Y.': [3261, 4951, 5272, 5317, 5365], 'Ezashi': [3262], 'T.': [3263, 4974, 4982, 5010, 5020, 5022, 5036, 5187, 5197, 5199, 5213], 'Roberts': [3264], 'R.M.': [3265, 4684], '98:': [3274, 5252], '6138-6143Crossref': [3275], 'Transgenic': [3281], 'expressing': [3284], 'susceptible': [3290], 'LPS-induced,': [3292], 'IFNβ-mediated': [3293], 'septic': [3294], 'shock,': [3295], 'levels': [3299, 3527, 4431, 5160, 5171, 5292, 5332, 5389], 'potentiate': [3305], '4S.': [3310], 'Samarajiwa,': [3312], 'Hardy,': [3314, 4776], 'Owczarek,': [3317, 4774], 'Potentiation': [3324], 'mediated': [3333], 'process': [3336], 'trans-signaling': [3338, 4262, 4437, 4446], '(see': [3339], 'below),': [3340], 'major': [3344, 4346], 'method': [3345], 'transduction': [3348, 3822], 'sIL6R': [3350], 'sIL15R': [3352, 4251], '34Rubinstein': [3373, 4304], 'Kovar': [3375, 4306], 'Purton': [3377, 4308], 'Cho': [3379, 4310], 'Boyman': [3381, 4312], 'O.': [3382, 4313, 4905], 'Surh': [3383, 4314], '2006;': [3394, 3540, 4017, 4047, 4142, 4234, 4325, 4828, 4962, 4995, 5096], '103:': [3395, 4326, 5097], '9166-9171Crossref': [3396, 4327], '(327)': [3399, 4330], 'might': [3404], 'carrier': [3408], 'function,': [3409], 'increased': [3414, 5330, 5386], 'stability': [3416], 'enhanced': [3420], 'anti-tumor': [3422], 'xenograft': [3426], '(35McKenna': [3429], 'S.D.': [3430], 'Vergilis': [3431], 'Arulanandam': [3433], 'A.R.': [3434], 'Weiser': [3435], 'W.Y.': [3436], 'Nabioullin': [3437], 'Tepper': [3439], 'M.A.': [3440], '24:': [3446], '119-129Crossref': [3447], '(37)': [3450], 'Signal': [3453, 3929], 'Transduction': [3454], 'Domains': [3455], 'Pathways—The': [3457], 'lack': [3467, 5391], 'kinase': [3469], 'rely': [3473], 'associated': [3475, 5139], 'kinases': [3477], '(JAKs)': [3478], 'phosphorylate': [3480], 'transducing': [3484, 4459], 'molecules,': [3485, 3974], 'STAT': [3488, 3876], 'proteins,': [3489], 'ligand-induced': [3491], 'clustering.': [3493], 'preassociated': [3496, 3783], 'Tyk2': [3498, 3549], '(36Yan': [3499, 3566], 'H.': [3500, 3567, 3753, 3838, 4947, 4976, 5014, 5028, 5032, 5191, 5205, 5209], 'Krishnan': [3501, 3568], 'Lim': [3503, 3570], 'J.T.': [3504, 3571], 'Contillo': [3505, 3572], 'L.G.': [3506, 3573], '16:': [3513, 3580], '2074-2082Crossref': [3514, 3581], '(88)': [3517, 3584, 5101], 'stabilizes': [3522], '(37Marijanovic': [3528], 'Z.': [3529], 'Ragimbeau': [3530], 'Kumar': [3532, 4007, 4224], 'K.G.': [3533, 4008, 4084, 4172, 4225], 'Fuchs': [3534, 4009, 4087, 4175, 4226], 'Pellegrini': [3536], '397:': [3541], '31-38Crossref': [3542], 'huIFNAR1': [3554], 'cytoplasmic': [3555], 'localized': [3559], 'encompassing': [3563], '479–511': [3565], 'HuIFNAR1': [3587], 'STAT1': [3590, 3678], 'STAT2': [3592, 3779], 'via': [3593], 'phospho-Tyr466': [3594], 'phospho-Tyr481': [3596], '(38Li': [3597, 3786], 'Leung': [3599, 3788], 'Kerr': [3601, 3790], 'I.M.': [3602, 3791], '17:': [3609, 3798], '2048-2056Crossref': [3610, 3799], '(165)': [3613, 3802], 'overexpressed': [3617], 'heterologous': [3619], 'STAT3': [3634, 3680], 'reportedly': [3635], 'undergoes': [3636], 'phosphotyrosine-dependent': [3638], '(39Yang': [3642], 'C.H.': [3643], 'Shi': [3644], 'W.': [3645, 4006, 4223, 5236], 'Basu': [3646], 'Murti': [3648], 'Constantinescu': [3650], 'S.N.': [3651], 'Blatt': [3652], 'Croze': [3654], 'Mullersman': [3656], 'J.E.': [3657, 4026, 4121, 4807], 'Pfeffer': [3658], '8057-8061Abstract': [3665], '(123)': [3673], 'homo-': [3681], 'heterodimer': [3683], 'treatment': [3687], 'Using': [3722], 'truncation': [3723], 'mutants': [3724], 'intracellular': [3727, 3810], 'huIFNAR2,': [3730], 'Jak1': [3734, 4212], '47-aa': [3740], '(40Domanski': [3742], 'Nadeau': [3746], 'O.W.': [3747], 'Witte': [3748], 'Platanias': [3750], 'Yan': [3752, 3837], 'Pitha': [3756], 'Colamonici': [3758], 'O.R.': [3759], '26388-26393Abstract': [3765], '(70)': [3773], 'Jak1,': [3776], 'STAT1,': [3777], 'molecules': [3814, 4438], 'STATs': [3817], 'multimolecular': [3820], 'complexes': [3823], '(42Nguyen': [3831], 'V.P.': [3832], 'Saleh': [3833], 'Piazza': [3839], 'Kim': [3841, 4001, 4218], '277:': [3849], '9713-9721Abstract': [3850], '(36)': [3858], 'Further': [3861], 'activation': [3870], 'pathways': [3873, 3897, 5606], 'non-STAT': [3879], '"alternative"': [3895], 'include': [3898], 'CrkL,': [3899], 'Rap1,': [3900], 'MAP': [3901], 'kinases,': [3902], 'Vav,': [3903], 'RAC1,': [3904], 'PI': [3905], '3-kinase,': [3906], 'IRS1': [3907], '-2,': [3909], 'PMRT1,': [3910], 'Sin1': [3912], 'Negative': [3926], 'Regulation': [3927], 'Transduction—The': [3930], 'signals': [3933, 4805, 4843, 5615], 'protect': [3938], 'host': [3940, 5432], 'against': [3941, 4709, 4869], 'cancer': [3944], 'mount': [3946], 'controlled': [3947], 'immune': [3948, 4719, 5132, 5459], 'responses,': [3949], 'excessive': [3951], 'deregulated': [3953], 'lead': [3956], 'toxicity,': [3958], 'leucopenia,': [3959], 'autoimmunity,': [3960], 'death.': [3963], 'Thus,': [3964], 'interact': [3967, 4204], 'SOCS-1': [3976, 4115], '(suppressor': [3977], 'signaling),': [3980], 'UBP43,': [3981, 4200], 'SHP': [3983], '(43You': [3984], 'Yu': [3986], 'D.H.': [3987], 'Feng': [3988], 'G.S.': [3989], '19:': [3994], '2416-2424Crossref': [3995], '44Malakhova': [3999], 'O.A.': [4000, 4217], 'K.I.': [4002, 4219], 'Luo': [4003, 4220], 'J.K.': [4004, 4221], 'Zou': [4005, 4222], 'Shuai': [4011, 4228], 'D.E.': [4014, 4231, 5241], '2358-2367Crossref': [4019, 4236], '(325)': [4022, 4239], '45Fenner': [4025], 'Starr': [4027, 4122, 4808], 'Cornish': [4029, 4124, 4810], 'A.L.': [4030, 4125, 4811], 'J.G.': [4032, 4127, 4813], 'Metcalf': [4033, 4128, 4814], 'R.D.': [4036, 4131, 4817], 'Sheehan': [4037, 4132, 4818], 'Hilton': [4039, 4134, 4820], 'Alexander': [4041, 4136, 4822], 'W.S.': [4042, 4137, 4823], '7:': [4048, 4143, 4829, 4963], '33-39Crossref': [4049, 4144, 4830], 'limit': [4056], 'extent': [4058], 'signaling.': [4060], 'C': [4062, 5007, 5287], 'spanning': [4071], '14': [4072], 'acids,': [4074], 'mediates': [4076], 'inhibition': [4077], '(46Kumar': [4083, 4171], '279:': [4093, 4181], '46614-46620Abstract': [4094, 4182], '(117)': [4102, 4190], 'occur': [4107], 'JAK/STAT': [4118, 5582], '(45Fenner': [4120, 4806], 'recruitment': [4159], 'E3': [4161], 'ubiquitin': [4162], 'ligases': [4163], 'ubiquitination': [4165], 'degradation': [4167], 'IFN-inducible': [4197], 'protease,': [4199], 'shown': [4202], 'directly': [4205], 'blocking': [4208], '(44Malakhova': [4216], 'Trans-signaling—Soluble': [4242], 'sIL6R,': [4247], 'sCNTFR,': [4248], 'sIL11R,': [4249], 'mechanism': [4259, 4347, 4457, 4837], 'known': [4260], 'Trans-signaling': [4265], 'occurs': [4266], 'interacts': [4273], 'complementary': [4276], 'gp130': [4341, 4352], 'shows': [4364], 'restricted': [4365], '(47Jones': [4367], 'Biochim.': [4371], 'Biophys.': [4372, 5044, 5221], 'Acta.': [4373], '1592:': [4375], '251-263Crossref': [4376], '(224)': [4379], 'We': [4382, 4727], 'transduce': [4395], 'Furthermore,': [4421], 'overexpressing': [4426], 'vivo.4': [4440], 'direct': [4443], 'required,': [4452], 'provides': [4454], 'compelling': [4456], 'signals.': [4461], 'Expression': [4462], 'Patterns—All': [4463], 'organs': [4466], 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[4876, 5067], 'B.J.': [4877, 5068], 'Fitness': [4878], 'Frodsham': [4880], 'Kwiatkowski': [4884], 'Hill': [4886, 5087], 'A.V.': [4887, 5088], 'Genes': [4888, 4960], 'Immun.': [4889, 4961], '4:': [4891], '275-282Crossref': [4892], 'sclerosis': [4901], '(51Leyva': [4902], 'Fernandez': [4904, 4910], 'Fedetz': [4906], 'Blanco': [4908], 'V.E.': [4911], 'Oliver': [4912], 'Leon': [4914], 'Pinto-Medel': [4916], 'Mayorga': [4918], 'Guerrero': [4920], 'Luque': [4922], 'Alcina': [4924], 'Matesanz': [4926], 'Neuroimmunol.': [4929], '163:': [4931], '165-171Abstract': [4932], '(79)': [4940], 'trypanosomaiasis': [4943], '(52Kierstein': [4944], 'Noyes': [4946], 'Naessens': [4948], 'Nakamura': [4950], 'Pritchard': [4952], 'Gibson': [4954], 'Kemp': [4956], 'Brass': [4958], '667-679Crossref': [4964], '(16)': [4967], 'HIV': [4970], '(53Diop': [4971], 'Hirtzig': [4973], 'Do': [4975], 'Coulonges': [4977], 'Vasilescu': [4979], 'Labib': [4981], 'Spadoni': [4983], 'Therwath': [4985], 'Lathrop': [4987], 'Matsuda': [4989], 'Zagury': [4991], 'Biomed.': [4993], 'Pharmacother.': [4994], '569-577Crossref': [4997], '(25)': [5000], 'hepatitis': [5004, 5286], 'virus': [5008], '(54Saito': [5009, 5186], 'Ji': [5011, 5188], 'Shinzawa': [5013, 5190], 'Okumoto': [5015, 5192], 'Hattori': [5017, 5194], 'Adachi': [5019, 5196], 'Takeda': [5021, 5198], 'Sugahara': [5023, 5200], 'Ito': [5025, 5202], 'J.I.': [5026, 5078, 5203], 'Watanabe': [5027, 5204], 'Saito': [5029, 5206], 'Togashi': [5031, 5208], 'Ishii': [5033, 5210], 'Matsuura': [5035, 5212], 'Inageda': [5037, 5214], 'Muramatsu': [5039, 5216], 'Kawata': [5041, 5218], 'Commun.': [5046, 5223], '317:': [5048, 5225], '335-341Crossref': [5049, 5226], '(46)': [5052, 5229], '55Frodsham': [5055], 'Dumpis': [5059], 'Taib': [5061], 'N.A.': [5062], 'Best': [5063], 'Durham': [5065], 'Hellier': [5069], 'Knapp': [5071], 'Wright': [5073], 'Chiaramonte': [5075], 'Bell': [5077], 'Graves': [5079], 'Whittle': [5081], 'H.C.': [5082, 5084], 'Thomas': [5083], 'Thursz': [5085], '9148-9153Crossref': [5098], 'influenced': [5105], 'polymorphisms.': [5108], 'Down': [5110], 'syndrome,': [5111], 'HSA': [5113], '21': [5114], 'trisomic,': [5122], 'sensitive': [5126], 'treatment;': [5129], 'condition': [5136], '(56Kola': [5144], 'Hum.': [5148], 'Genet.': [5150], '6:': [5152], '1713-1727Crossref': [5153], '(59)': [5156], 'assessed': [5166], 'condition.': [5169], 'Increased': [5170], 'reported': [5176], 'chronic': [5179, 5285], 'cancers,': [5182], 'urological': [5184], 'diseases': [5185], '57Ambrus': [5232], 'Sr.,': [5233], 'Dembinski': [5235], 'Ambrus': [5237], 'Jr.,': [5238], 'Sykes': [5240], 'Akhter': [5242], 'Kulaylat': [5244], 'M.N.': [5245], 'Islam': [5246], 'Chadha': [5248], 'K.C.': [5249], 'Cancer.': [5250], '2730-2733Crossref': [5253], '(34)': [5256], '58Mizukoshi': [5259], 'Kaneko': [5261, 5306, 5354], 'Kaji': [5263, 5308, 5356], 'Terasaki': [5265, 5310, 5358], 'Matsushita': [5267, 5312, 5360], 'Muraguchi': [5269, 5314, 5362], 'Ohmoto': [5271, 5316, 5364], 'Kobayashi': [5273, 5318, 5366], 'Hepatology.': [5275, 5320, 5368], '30:': [5277, 5322, 5370], '1325-1331Crossref': [5278, 5323, 5371], '(42)': [5281, 5326, 5374], 'During': [5284], 'infection,': [5288], 'total': [5289], 'serum': [5297, 5331, 5339, 5388], 'increase': [5299], 'than': [5302, 5563], '10-fold': [5303], '(58Mizukoshi': [5304, 5352], 'correlated': [5335], 'increases': [5337], '2–5': [5340], 'oligoadenylate': [5341], 'synthetase': [5342], '(p': [5344], '<': [5345], '0.001)': [5346], 'suggestive': [5347], 'potentiated': [5349], 'Interestingly,': [5377], 'correlation': [5384], 'therapy.': [5396], 'importance': [5399], 'once': [5409], 'ascertained': [5413], 'whether': [5414], 'participates': [5416], 'activities,': [5422], 'above': [5424], 'support': [5426], 'former.': [5428], 'Not': [5429], 'do': [5431], 'produce': [5434], 'certain': [5441], 'viruses': [5442], 'evolved': [5444], 'means': [5455], 'evading': [5457], 'response.': [5460, 5596], 'Poxvirus': [5461], 'homologue': [5467], 'neutralizes': [5469], 'tested,': [5474], 'virulence': [5479], '(41Symons': [5480], 'Alcami': [5482], 'G.L.': [5485], '81:': [5488], '551-560Abstract': [5489], '(425)': [5495], 'unusual': [5501], 'tertiary': [5518], 'structural': [5519, 5641], 'similarity,': [5520], 'modeling': [5523], 'studies,': [5524], 'inhibitor': [5529], 'broad': [5536], 'without': [5542], 'specificity': [5545], 'mammalian': [5547], 'IFN-IFNAR': [5548], 'interactions.': [5549], 'novel': [5554], '15': [5564], 'ligands.': [5571], 'instrumental': [5576], 'discovery': [5579], 'pathway,': [5584], 'regulating': [5589], 'emerging': [5598], 'so-called': [5604], 'activated': [5608], 'activation.': [5611], 'explain': [5617], 'There': [5624], 'considerable': [5627], 'advance': [5628], 'understanding': [5630], 'complex.': [5637], 'detailed': [5640], 'confirmation': [5644], 'difference': [5648], 'configurations,': [5651], 'like': [5652], 'would': [5655], 'trans-signaling,': [5657], 'receptor.': [5676]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031423498', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 21}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 23}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 29}, {'year': 2017, 'cited_by_count': 27}, {'year': 2016, 'cited_by_count': 28}, {'year': 2015, 'cited_by_count': 30}, {'year': 2014, 'cited_by_count': 26}, {'year': 2013, 'cited_by_count': 31}, {'year': 2012, 'cited_by_count': 26}], 'updated_date': '2024-12-15T18:17:11.978926', 'created_date': '2016-06-24'}
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