Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2031406915', 'doi': 'https://doi.org/10.1038/jcbfm.2010.33', 'title': 'Human Recombinant Tissue-Plasminogen Activator (Alteplase): Why Not Use the ‘Human’ Dose for Stroke Studies in Rats?', 'display_name': 'Human Recombinant Tissue-Plasminogen Activator (Alteplase): Why Not Use the ‘Human’ Dose for Stroke Studies in Rats?', 'publication_year': 2010, 'publication_date': '2010-03-10', 'ids': {'openalex': 'https://openalex.org/W2031406915', 'doi': 'https://doi.org/10.1038/jcbfm.2010.33', 'mag': '2031406915', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20216551', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2949192'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/jcbfm.2010.33', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2010.33', 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2010.33', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079483091', 'display_name': 'Benoît Haelewyn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154143', 'display_name': 'Cyceron', 'ror': 'https://ror.org/04zeq1c51', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210154143']}, {'id': 'https://openalex.org/I2738703131', 'display_name': "Commissariat à l'Énergie Atomique et aux Énergies Alternatives", 'ror': 'https://ror.org/00jjx8s55', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2738703131']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Benoît Haelewyn', 'raw_affiliation_strings': ['ERT 1083 ‘Pharmacologie et Formulation de Gaz-Médicaments’, Université de Caen, CNRS, CEA, Centre CYCERON, Boulevard Becquerel, Caen, France', 'NNOXe Pharmaceuticals, Quebec City, Quebec, Canada'], 'affiliations': [{'raw_affiliation_string': 'NNOXe Pharmaceuticals, Quebec City, Quebec, Canada', 'institution_ids': []}, {'raw_affiliation_string': 'ERT 1083 ‘Pharmacologie et Formulation de Gaz-Médicaments’, Université de Caen, CNRS, CEA, Centre CYCERON, Boulevard Becquerel, Caen, France', 'institution_ids': ['https://openalex.org/I4210154143', 'https://openalex.org/I2738703131', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089164885', 'display_name': 'Jean‐Jacques Risso', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I143002897', 'display_name': 'Université de Toulon', 'ror': 'https://ror.org/02m9kbe37', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I143002897']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-Jacques Risso', 'raw_affiliation_strings': ['IRBA, Antenne Toulon, France'], 'affiliations': [{'raw_affiliation_string': 'IRBA, Antenne Toulon, France', 'institution_ids': ['https://openalex.org/I143002897']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5075968525', 'display_name': 'Jacques H. Abraini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154143', 'display_name': 'Cyceron', 'ror': 'https://ror.org/04zeq1c51', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210154143']}, {'id': 'https://openalex.org/I2738703131', 'display_name': "Commissariat à l'Énergie Atomique et aux Énergies Alternatives", 'ror': 'https://ror.org/00jjx8s55', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2738703131']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Jacques H Abraini', 'raw_affiliation_strings': ['ERT 1083 ‘Pharmacologie et Formulation de Gaz-Médicaments’, Université de Caen, CNRS, CEA, Centre CYCERON, Boulevard Becquerel, Caen, France'], 'affiliations': [{'raw_affiliation_string': 'ERT 1083 ‘Pharmacologie et Formulation de Gaz-Médicaments’, Université de Caen, CNRS, CEA, Centre CYCERON, Boulevard Becquerel, Caen, France', 'institution_ids': ['https://openalex.org/I4210154143', 'https://openalex.org/I2738703131', 'https://openalex.org/I1294671590']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5075968525'], 'corresponding_institution_ids': ['https://openalex.org/I4210154143', 'https://openalex.org/I2738703131', 'https://openalex.org/I1294671590'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.265, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.947309, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '30', 'issue': '5', 'first_page': '900', 'last_page': '903'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10227', 'display_name': 'Epidemiology and Management of Stroke', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10227', 'display_name': 'Epidemiology and Management of Stroke', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12030', 'display_name': 'S100 Proteins: Structure, Function, and Pathology', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 0.9934, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stroke', 'display_name': 'Stroke (engine)', 'score': 0.6833262}, {'id': 'https://openalex.org/keywords/t-plasminogen-activator', 'display_name': 'T-plasminogen activator', 'score': 0.58336145}, {'id': 'https://openalex.org/keywords/infarction-treatment', 'display_name': 'Infarction Treatment', 'score': 0.509047}, {'id': 'https://openalex.org/keywords/fibrinolytic-agent', 'display_name': 'Fibrinolytic agent', 'score': 0.47294664}], 'concepts': [{'id': 'https://openalex.org/C2911092318', 'wikidata': 'https://www.wikidata.org/wiki/Q416351', 'display_name': 'Recombinant tissue plasminogen activator', 'level': 5, 'score': 0.77096915}, {'id': 'https://openalex.org/C2776572282', 'wikidata': 'https://www.wikidata.org/wiki/Q416351', 'display_name': 'Tissue plasminogen activator', 'level': 2, 'score': 0.7448291}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.68593276}, {'id': 'https://openalex.org/C2780645631', 'wikidata': 'https://www.wikidata.org/wiki/Q671554', 'display_name': 'Stroke (engine)', 'level': 2, 'score': 0.6833262}, {'id': 'https://openalex.org/C2909373784', 'wikidata': 'https://www.wikidata.org/wiki/Q416351', 'display_name': 'T-plasminogen activator', 'level': 3, 'score': 0.58336145}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5396384}, {'id': 'https://openalex.org/C2779581417', 'wikidata': 'https://www.wikidata.org/wiki/Q1931577', 'display_name': 'Thrombolysis', 'level': 3, 'score': 0.5059442}, {'id': 'https://openalex.org/C2779679481', 'wikidata': 'https://www.wikidata.org/wiki/Q13581432', 'display_name': 'Plasminogen activator', 'level': 2, 'score': 0.48121026}, {'id': 'https://openalex.org/C2909817843', 'wikidata': 'https://www.wikidata.org/wiki/Q575222', 'display_name': 'Fibrinolytic agent', 'level': 3, 'score': 0.47294664}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.42067745}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.37189576}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.36014438}, {'id': 'https://openalex.org/C3020199598', 'wikidata': 'https://www.wikidata.org/wiki/Q12202', 'display_name': 'Ischemic stroke', 'level': 3, 'score': 0.31183195}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29042065}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.14296463}, {'id': 'https://openalex.org/C500558357', 'wikidata': 'https://www.wikidata.org/wiki/Q12152', 'display_name': 'Myocardial infarction', 'level': 2, 'score': 0.07007021}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.06548676}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2780931571', 'wikidata': 'https://www.wikidata.org/wiki/Q568775', 'display_name': 'Modified Rankin Scale', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005343', 'descriptor_name': 'Fibrinolytic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010959', 'descriptor_name': 'Tissue Plasminogen Activator', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002560', 'descriptor_name': 'Cerebrovascular Circulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002560', 'descriptor_name': 'Cerebrovascular Circulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005343', 'descriptor_name': 'Fibrinolytic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005343', 'descriptor_name': 'Fibrinolytic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012039', 'descriptor_name': 'Regional Blood Flow', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012039', 'descriptor_name': 'Regional Blood Flow', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010959', 'descriptor_name': 'Tissue Plasminogen Activator', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010959', 'descriptor_name': 'Tissue Plasminogen Activator', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010959', 'descriptor_name': 'Tissue Plasminogen Activator', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/jcbfm.2010.33', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2010.33', 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2949192', 'pdf_url': 'https://europepmc.org/articles/pmc2949192?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20216551', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/jcbfm.2010.33', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2010.33', 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.79, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 15, 'referenced_works': ['https://openalex.org/W1861164204', 'https://openalex.org/W1982830249', 'https://openalex.org/W2021938872', 'https://openalex.org/W2043163117', 'https://openalex.org/W2055611204', 'https://openalex.org/W2072926617', 'https://openalex.org/W2076751149', 'https://openalex.org/W2077842614', 'https://openalex.org/W2108523726', 'https://openalex.org/W2110895095', 'https://openalex.org/W2112646710', 'https://openalex.org/W2148957771', 'https://openalex.org/W2159196762', 'https://openalex.org/W233118278', 'https://openalex.org/W318008796'], 'related_works': ['https://openalex.org/W3012497495', 'https://openalex.org/W2419452379', 'https://openalex.org/W2379402413', 'https://openalex.org/W2342256744', 'https://openalex.org/W2087950998', 'https://openalex.org/W2081351125', 'https://openalex.org/W2041315352', 'https://openalex.org/W2031406915', 'https://openalex.org/W2005456024', 'https://openalex.org/W165533477'], 'abstract_inverted_index': {'Since': [0], 'a': [1, 68], 'pioneer': [2], 'work': [3], 'that': [4, 9, 78, 89], 'has': [5], 'shown': [6], 'in': [7, 42, 67, 97], 'vitro': [8], 'the': [10, 24, 50, 79], "rat's": [11], 'fibrinolytic': [12], 'system': [13], 'is': [14, 85], '10-fold': [15], 'less': [16], 'sensitive': [17], 'to': [18, 58], 'recombinant': [19], 'tissue-plasminogen': [20], 'activator': [21], '(rtPA)': [22], 'than': [23], 'human': [25], 'system,': [26], 'most': [27], 'preclinical': [28, 94], 'studies': [29, 96], 'are': [30], 'performed': [31], 'with': [32], '10': [33, 91], 'instead': [34], 'of': [35, 52, 71, 81, 90], '0.9': [36, 82], 'mg/kg': [37, 83, 92], 'rtPA': [38, 84], '(the': [39], 'clinical': [40], 'dose': [41, 80], 'stroke': [43, 95], 'patients).': [44], 'In': [45], 'this': [46], 'study,': [47], 'we': [48], 'compared': [49], 'effects': [51], 'these': [53], 'doses': [54], 'on': [55], 'mean': [56], 'time': [57], 'reperfusion,': [59], 'reperfusion': [60], 'slope,': [61], 'brain': [62], 'infarct': [63], 'volume': [64], 'and': [65], 'edema': [66], 'rat': [69], 'model': [70], 'thrombo-embolic': [72], 'stroke.': [73], 'Our': [74], 'data': [75], 'provide': [76], 'evidence': [77], 'as': [86, 88], 'appropriate': [87], 'for': [93], 'rodents.': [98]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031406915', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-08-14T02:56:10.564669', 'created_date': '2016-06-24'}