Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2031351595', 'doi': 'https://doi.org/10.1002/(sici)1097-0142(19981115)83:10<2185::aid-cncr18>3.0.co;2-4', 'title': 'Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas', 'display_name': 'Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas', 'publication_year': 1998, 'publication_date': '1998-11-15', 'ids': {'openalex': 'https://openalex.org/W2031351595', 'doi': 'https://doi.org/10.1002/(sici)1097-0142(19981115)83:10<2185::aid-cncr18>3.0.co;2-4', 'mag': '2031351595', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9827724'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-0142(19981115)83:10<2185::aid-cncr18>3.0.co;2-4', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819981115%2983%3A10%3C2185%3A%3AAID-CNCR18%3E3.0.CO%3B2-4', 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819981115%2983%3A10%3C2185%3A%3AAID-CNCR18%3E3.0.CO%3B2-4', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027117186', 'display_name': 'Rossella Elisei', 'orcid': 'https://orcid.org/0000-0002-5333-9257'}, 'institutions': [{'id': 'https://openalex.org/I92156820', 'display_name': 'University of Cincinnati Medical Center', 'ror': 'https://ror.org/02p72h367', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I92156820']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rossella Elisei', 'raw_affiliation_strings': ['Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Ohio 45267, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Ohio 45267, USA.', 'institution_ids': ['https://openalex.org/I92156820']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109945740', 'display_name': 'Masaaki Shiohara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1282927834', 'display_name': 'Cedars-Sinai Medical Center', 'ror': 'https://ror.org/02pammg90', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1282927834']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Masaaki Shiohara', 'raw_affiliation_strings': ['Hematology/Oncology Division, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California'], 'affiliations': [{'raw_affiliation_string': 'Hematology/Oncology Division, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California', 'institution_ids': ['https://openalex.org/I1282927834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082903377', 'display_name': 'H. Phillip Koeffler', 'orcid': 'https://orcid.org/0000-0001-5839-9913'}, 'institutions': [{'id': 'https://openalex.org/I1282927834', 'display_name': 'Cedars-Sinai Medical Center', 'ror': 'https://ror.org/02pammg90', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1282927834']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'H. Phillip Koeffler', 'raw_affiliation_strings': ['Hematology/Oncology Division, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California'], 'affiliations': [{'raw_affiliation_string': 'Hematology/Oncology Division, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California', 'institution_ids': ['https://openalex.org/I1282927834']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080716045', 'display_name': 'James A. Fagin', 'orcid': 'https://orcid.org/0000-0002-2365-2517'}, 'institutions': [{'id': 'https://openalex.org/I92156820', 'display_name': 'University of Cincinnati Medical Center', 'ror': 'https://ror.org/02p72h367', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I92156820']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James A. Fagin', 'raw_affiliation_strings': ['Division of Endocrinology and Metabolism, University of Cincinnati, College of Medicine, Cincinnati, Ohio'], 'affiliations': [{'raw_affiliation_string': 'Division of Endocrinology and Metabolism, University of Cincinnati, College of Medicine, Cincinnati, Ohio', 'institution_ids': ['https://openalex.org/I92156820']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4740, 'currency': 'USD', 'value_usd': 4740, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.305, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 72, 'citation_normalized_percentile': {'value': 0.948121, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '83', 'issue': '10', 'first_page': '2185', 'last_page': '2193'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10329', 'display_name': 'Thyroid Cancer Diagnosis and Treatment', 'score': 0.9861, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.916, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.7199135}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.52232045}, {'id': 'https://openalex.org/C2993294228', 'wikidata': 'https://www.wikidata.org/wiki/Q13632630', 'display_name': 'Thyroid carcinoma', 'level': 3, 'score': 0.4826944}, {'id': 'https://openalex.org/C124320809', 'wikidata': 'https://www.wikidata.org/wiki/Q46292', 'display_name': 'Cyclin-dependent kinase', 'level': 4, 'score': 0.4677579}, {'id': 'https://openalex.org/C2778264664', 'wikidata': 'https://www.wikidata.org/wiki/Q422445', 'display_name': 'Tumor suppressor gene', 'level': 4, 'score': 0.4673396}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.37049985}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.33978677}, {'id': 'https://openalex.org/C526584372', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Thyroid', 'level': 2, 'score': 0.28891382}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.24566776}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.17085075}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16167024}], 'mesh': [{'descriptor_ui': 'D000236', 'descriptor_name': 'Adenoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002291', 'descriptor_name': 'Carcinoma, Papillary', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019941', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p16', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D016147', 'descriptor_name': 'Genes, Tumor Suppressor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017354', 'descriptor_name': 'Point Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000236', 'descriptor_name': 'Adenoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015139', 'descriptor_name': 'Blotting, Southern', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002291', 'descriptor_name': 'Carcinoma, Papillary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050762', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p15', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019941', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p16', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016147', 'descriptor_name': 'Genes, Tumor Suppressor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-0142(19981115)83:10<2185::aid-cncr18>3.0.co;2-4', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819981115%2983%3A10%3C2185%3A%3AAID-CNCR18%3E3.0.CO%3B2-4', 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9827724', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-0142(19981115)83:10<2185::aid-cncr18>3.0.co;2-4', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819981115%2983%3A10%3C2185%3A%3AAID-CNCR18%3E3.0.CO%3B2-4', 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.55, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1497143324', 'https://openalex.org/W1501631032', 'https://openalex.org/W1560647015', 'https://openalex.org/W1579542618', 'https://openalex.org/W1590316048', 'https://openalex.org/W17178929', 'https://openalex.org/W1757681454', 'https://openalex.org/W1971512164', 'https://openalex.org/W1974513412', 'https://openalex.org/W1974764716', 'https://openalex.org/W1977706798', 'https://openalex.org/W1982745900', 'https://openalex.org/W1983348452', 'https://openalex.org/W1987817896', 'https://openalex.org/W1990677813', 'https://openalex.org/W1994082723', 'https://openalex.org/W1997073961', 'https://openalex.org/W1998838388', 'https://openalex.org/W2003907692', 'https://openalex.org/W2010493387', 'https://openalex.org/W2024342549', 'https://openalex.org/W2030916051', 'https://openalex.org/W2035882662', 'https://openalex.org/W2037799987', 'https://openalex.org/W2042078307', 'https://openalex.org/W2046577405', 'https://openalex.org/W2046986524', 'https://openalex.org/W2064850972', 'https://openalex.org/W2066848701', 'https://openalex.org/W2067795112', 'https://openalex.org/W2081282586', 'https://openalex.org/W2086773265', 'https://openalex.org/W2089921110', 'https://openalex.org/W2092200570', 'https://openalex.org/W2093094352', 'https://openalex.org/W2112925965', 'https://openalex.org/W2116327026', 'https://openalex.org/W2122580718', 'https://openalex.org/W2123944316', 'https://openalex.org/W2130198345', 'https://openalex.org/W2138544437', 'https://openalex.org/W2167355591', 'https://openalex.org/W2168261275', 'https://openalex.org/W2273677386', 'https://openalex.org/W2279481864', 'https://openalex.org/W2300127060', 'https://openalex.org/W2301048882', 'https://openalex.org/W2417219239', 'https://openalex.org/W2470517880', 'https://openalex.org/W4236193966', 'https://openalex.org/W4243098077'], 'related_works': ['https://openalex.org/W3024406102', 'https://openalex.org/W2379132232', 'https://openalex.org/W2326310410', 'https://openalex.org/W2171132469', 'https://openalex.org/W2114604954', 'https://openalex.org/W2054836553', 'https://openalex.org/W2027857309', 'https://openalex.org/W1991077994', 'https://openalex.org/W1985940796', 'https://openalex.org/W1516326873'], 'abstract_inverted_index': {'D-type': [0], 'cyclins,': [1], 'in': [2, 47, 113, 187, 201, 232, 245, 249, 270, 280, 282, 290, 302, 327, 349], 'association': [3], 'with': [4], 'the': [5, 14, 18, 48, 51, 57, 89, 114, 125, 150, 162, 169, 188, 202, 219, 271, 295, 328, 341, 354], 'cyclin-dependent': [6], 'kinases': [7], 'CDK4': [8, 43], 'and': [9, 30, 37, 42, 54, 71, 75, 85, 91, 102, 127, 173, 193, 267, 318], 'CDK6,': [10], 'promote': [11], 'progression': [12], 'through': [13], 'G1': [15], 'phase': [16], 'of': [17, 33, 35, 50, 59, 88, 109, 147, 179, 190, 213, 216, 234, 251, 261, 265, 277, 294, 316, 330, 340, 345, 356], 'cell': [19, 52, 61, 80, 116, 204, 272, 313], 'cycle.': [20], 'CDK': [21], 'activity': [22], 'is': [23, 347], 'modulated': [24], 'by': [25, 94], 'inhibitors': [26], 'such': [27], 'as': [28, 362], 'p15INK4b': [29, 36, 90, 317], 'p16INK4a.': [31, 180, 217], 'Loss': [32], 'function': [34, 355], 'p16INK4a': [38, 92, 319], '(multiple': [39], 'tumor': [40, 297], 'suppressor-I': [41], 'inhibitor)': [44], 'determines': [45], 'impairment': [46], 'control': [49], 'cycle': [53], 'contributes': [55], 'to': [56, 208, 323], 'transformation': [58], 'several': [60], 'types.The': [62], 'authors': [63], 'examined': [64], '20': [65, 252], 'thyroid': [66, 78, 221, 237], 'neoplasms': [67], '(12': [68], 'papillary': [69, 153, 236, 334], 'carcinomas': [70, 238], '8': [72], 'follicular': [73, 120, 246, 331], 'adenomas)': [74], '4': [76], 'human': [77], 'carcinoma': [79, 121, 134, 154], 'lines': [81, 117, 273], 'for': [82, 301], 'gene': [83, 358], 'mutations': [84, 242, 269, 306], 'epigenetic': [86, 364], 'modifications': [87], 'genes': [93, 129, 279], 'Southern': [95], 'blot': [96], 'analysis,': [97], 'single': [98], 'strand': [99], 'conformation': [100], 'polymorphism,': [101], 'a': [103, 138, 158, 209, 223, 291], 'polymerase': [104], 'chain': [105], 'reaction-based': [106], 'methylation': [107, 212, 339], 'assay.Abnormalities': [108], 'p16': [110, 128, 182, 197, 268, 285, 305, 346], 'were': [111, 130, 243, 299], 'found': [112, 231, 244], 'four': [115], 'studied.': [118], 'In': [119], '(WRO)': [122], 'cells,': [123], 'both': [124, 191], 'p15': [126, 266], 'homozygously': [131], 'deleted.': [132], 'Undifferentiated': [133], '(FRO)': [135], 'cells': [136], 'had': [137], 'nonsense': [139], 'point': [140, 159, 225], 'mutation': [141, 160, 226], 'at': [142, 161, 227, 258], 'codon': [143, 228], '72': [144], '(CGA-TGA,': [145], 'Arg-Stop)': [146], 'p16,': [148], 'whereas': [149], 'poorly': [151], 'differentiated': [152], '(NPA)': [155], 'line': [156], 'harbored': [157], 'exon': [163, 214, 259], '1-intron': [164], '1': [165, 215, 233, 260], 'boundary': [166], 'that': [167, 298, 353], 'altered': [168], 'donor': [170], 'splicing': [171], 'site': [172], 'caused': [174], 'an': [175, 363], 'aberrantly': [176], 'spliced': [177], 'form': [178], 'Furthermore,': [181], 'allelic': [183], 'loss': [184], 'was': [185, 199, 230, 256], 'evident': [186], 'DNA': [189], 'FRO': [192], 'NPA': [194], 'cells.': [195], 'Finally,': [196], 'expression': [198], 'absent': [200], 'ARO': [203], 'line,': [205], 'likely': [206], 'due': [207], 'de': [210, 310, 337], 'novo': [211, 311, 338], 'Regarding': [218], 'primary': [220, 253, 296, 350], 'tumors,': [222, 351], 'missense': [224], '91': [229], '12': [235], '(GCC-GTC,': [239], 'Ala-Val).': [240], 'No': [241], 'adenomas.': [247], 'However,': [248, 336], '6': [250], 'tumors': [254], 'there': [255], 'hypermethylation': [257], 'p16.The': [262], 'high': [263], 'prevalence': [264], 'described': [274], 'suggests': [275], 'involvement': [276], 'these': [278], 'immortalization': [281], 'vitro.': [283, 303], 'The': [284], 'defects': [286], 'may': [287, 307, 359], 'have': [288, 308], 'preexisted': [289], 'small': [292], 'subclone': [293], 'selected': [300], 'Alternatively,': [304], 'arisen': [309], 'during': [312, 366], 'culture.': [314], 'Mutations': [315], 'do': [320], 'not': [321], 'appear': [322], 'be': [324, 360], 'critical': [325], 'events': [326], 'development': [329], 'adenomas': [332], 'or': [333], 'carcinomas.': [335], "5'": [342], 'CpG': [343], 'island': [344], 'common': [348], 'indicating': [352], 'this': [357], 'lost': [361], 'event': [365], 'disease': [367], 'progression.': [368]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031351595', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-14T01:44:40.322500', 'created_date': '2016-06-24'}