Identification of Novel β1 Integrin Binding Sites in the Type 1 and Type 2 Repeats of Thrombospondin-1

Name: Work Video:
Duration: 3 min 30 s
Marı́a J. Calzada; Douglas S. Annis; Bixi Zeng; Cezary Marcinkiewicz; Bernhard Banas; Jack Lawler; Deane F. Mosher; David D. Roberts
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3528, 3545, 3585, 3846, 3880, 3964, 3981, 4083, 4191, 4200, 4212, 4445, 4460, 4588, 4608], 'integrin': [7, 41, 56, 148, 248, 258, 292, 307, 399, 499, 564, 920, 960, 1272, 1293, 1416, 1590, 1611, 1668, 2085, 2306, 2371, 2652, 3212, 3285, 3459, 3485, 3546, 3586, 3965, 3989, 4213, 4234, 4360, 4446, 4609], 'recognition': [8, 45, 259, 296, 1294], 'sites': [9, 260, 566, 751, 962, 1200, 1228, 1241, 1264, 2654, 2777, 4226], 'in': [10, 43, 167, 191, 261, 294, 418, 442, 570, 575, 665, 752, 963, 1150, 1201, 1209, 1229, 1242, 1249, 1274, 1298, 1335, 1797, 1864, 1923, 1960, 1976, 2025, 2029, 2101, 2133, 2168, 2326, 2414, 2431, 2537, 2561, 2589, 2621, 2655, 2754, 3001, 3103, 3294, 3356, 3766, 3786, 3966, 3983, 3992, 4027, 4216, 4237, 4590, 4619], 'N-module': [12, 263, 769, 804, 1184, 2657], 'of': [13, 36, 49, 67, 72, 227, 239, 244, 264, 287, 300, 318, 323, 478, 490, 495, 556, 562, 581, 662, 757, 767, 872, 884, 978, 1093, 1104, 1123, 1133, 1142, 1153, 1178, 1189, 1206, 1215, 1232, 1254, 1262, 1268, 1295, 1330, 1434, 1573, 1986, 2171, 2174, 2200, 2321, 2332, 2385, 2411, 2453, 2515, 2639, 2658, 2745, 2752, 2759, 2805, 2839, 2857, 2952, 2970, 2997, 3010, 3256, 3314, 3333, 3342, 3382, 3421, 3428, 3519, 3582, 3648, 3732, 3734, 3743, 3864, 3869, 3961, 4082, 4176, 4223, 4240, 4244, 4301, 4318, 4320, 4329, 4333, 4359, 4367, 4375, 4469, 4480, 4502, 4532, 4575, 4604, 4635], 'thrombospondin-1': [14, 265], '(TSP1),': [15, 266], 'we': [16, 267, 1217, 1257, 4462, 4594], 'found': [17, 268], 'that': [18, 44, 51, 68, 74, 235, 269, 295, 302, 319, 325, 486, 540, 980, 1016, 1088, 1194, 1221, 1259, 1275, 1282, 2382, 2492, 2765, 2887, 2983, 3048, 3140, 3413, 3526, 3700, 3985, 4184, 4336, 4412, 4425, 4596, 4622], 'integrins': [20, 78, 94, 165, 271, 329, 345, 416, 590, 748, 2365, 2389, 2807, 2985, 3004, 3144, 3152, 3179, 3250, 3315, 3415, 3450, 3529, 3702, 3801, 3873, 3930, 3982, 4522, 4589], 'mediate': [21, 272], 'cell': [22, 118, 153, 273, 369, 404, 542, 1512, 1810, 1938, 1951, 2253, 2416, 2746, 2782, 2898, 2938, 2989, 3157, 3358, 3372, 3469, 3472, 3534, 3597, 3614, 3643, 3662, 3713, 3857, 3890, 3935, 3950, 3968, 4260, 4381, 4384, 4428], 'adhesion': [23, 71, 141, 154, 202, 212, 274, 322, 392, 405, 453, 463, 1132, 2747, 2776, 2821, 2836, 2940, 2971, 2990, 3100, 3158, 3240, 3373, 3387, 3420, 3462, 3473, 3503, 3514, 3535, 3598, 3688, 3714, 3784, 3936, 4175, 4261, 4309, 4319, 4362, 4371, 4468, 4531], 'type': [26, 29, 33, 59, 101, 106, 123, 144, 157, 160, 174, 194, 205, 217, 277, 280, 284, 310, 352, 357, 374, 395, 408, 411, 425, 445, 456, 468, 512, 578, 1027, 1107, 1251, 1402, 1980, 2767, 2770, 2797, 2843, 2921, 3012, 3050, 3379, 3390, 3465, 3476, 3506, 3601, 3665, 3696, 3861, 4409, 4433], '1': [27, 34, 60, 102, 107, 158, 175, 218, 278, 285, 311, 353, 358, 409, 426, 469, 513, 1028, 2096, 2187, 2190, 2194, 2217, 2263, 2333, 2480, 2546, 2602, 2619, 2768, 3051, 3432, 3466, 3477, 3507, 3862, 4434], 'and': [28, 86, 99, 104, 112, 137, 163, 208, 279, 337, 350, 355, 363, 388, 414, 459, 547, 588, 812, 1102, 1196, 1224, 1245, 1248, 1301, 1413, 1420, 1503, 1600, 1720, 1777, 1823, 1880, 1887, 1933, 2004, 2027, 2035, 2046, 2114, 2193, 2248, 2260, 2349, 2379, 2438, 2469, 2476, 2487, 2511, 2540, 2554, 2568, 2596, 2599, 2769, 2788, 2796, 2825, 2900, 2927, 2929, 3025, 3142, 3208, 3258, 3301, 3305, 3366, 3442, 3490, 3623, 3678, 3723, 3778, 3795, 3852, 3871, 3887, 3901, 3918, 3928, 4023, 4025, 4092, 4170, 4195, 4247, 4266, 4313, 4372, 4383, 4389, 4472, 4494, 4517, 4578, 4601], '2': [30, 124, 145, 161, 195, 206, 281, 375, 396, 412, 446, 457, 1108, 1252, 1804, 1934, 2022, 2242, 2559, 2771, 2798, 2844, 2922, 3380, 3391, 3602], 'repeats.': [31, 146, 219, 282, 397, 470], 'The': [32, 179, 283, 430, 572, 1474, 1523, 1588, 1609, 1666, 1715, 1948, 2000, 2223, 2252, 2273, 2336, 2361, 2457, 2482, 2531, 2842, 3033, 3406, 3497, 4316, 4365], 'repeats': [35, 61, 125, 207, 286, 312, 376, 458, 1029, 1109, 1253, 1297, 2772, 2845, 2923, 3052, 3381, 3392, 3427, 3467, 3478, 3508, 3603, 3863, 4435], 'TSP1': [37, 182, 216, 288, 433, 467, 549, 582, 667, 885, 964, 979, 1018, 1060, 1094, 1143, 1286, 1331, 1561, 1578, 1974, 2075, 2640, 2659, 2753, 2858, 2895, 3164, 3383, 3430, 3464, 3520, 3791, 3939, 4605, 4627], 'differ': [38, 289], 'from': [39, 242, 290, 493, 1266, 1305, 1406, 1510, 1515, 1583, 1605, 1662, 1784, 1973, 2283, 2301, 2309, 2584, 4455], 'typical': [40, 291, 4358], 'ligands': [42, 293, 1273, 4189, 4628], 'is': [46, 62, 79, 126, 150, 223, 297, 313, 330, 377, 401, 474, 535, 583, 921, 2889, 2902, 3541, 3739, 4436, 4448], 'pan-β1-specific.': [47, 298, 1278], 'Adhesion': [48, 120, 299, 371, 1968, 2951, 3009, 3970, 4347, 4479, 4501], 'cells': [50, 73, 301, 324, 552, 1135, 1781, 1794, 1829, 1886, 2058, 2129, 2162, 2397, 2786, 2869, 2874, 2907, 2954, 2999, 3014, 3070, 3296, 3327, 3345, 3423, 3551, 3770, 3788, 3805, 3836, 3984, 3994, 4029, 4077, 4178, 4304, 4322, 4471, 4475, 4483, 4504, 4535, 4540], 'express': [52, 75, 303, 326, 3330, 3986, 4078], 'one': [53, 304], 'dominant': [54, 305], 'on': [57, 308, 1059, 2427, 2919, 2955, 2972, 3068, 3159, 3269, 3424, 3463, 3474, 3504, 3515, 3536, 3599, 3616, 3664, 3689, 3693, 3754, 3774, 3859, 3937, 4262, 4345, 4386, 4392, 4408, 4430, 4536, 4572], 'immobilized': [58, 143, 309, 394], 'specifically': [63, 314, 3260], 'inhibited': [64, 81, 88, 315, 332, 339, 1055, 1116, 1127, 2962, 3395, 3481, 3502, 3513, 3594, 3620, 3641, 3669, 3711, 3855, 3883, 3888, 3975, 4404, 4421, 4489, 4510], 'by': [65, 82, 89, 214, 316, 333, 340, 465, 926, 984, 1117, 1128, 1145, 1427, 1529, 1566, 1673, 1994, 2142, 2203, 2312, 2340, 2358, 2393, 2643, 2943, 2963, 3023, 3030, 3039, 3055, 3059, 3262, 3320, 3396, 3482, 3509, 3521, 3548, 3621, 3629, 3764, 3803, 3892, 3905, 3913, 3955, 3976, 4199, 4208, 4220, 4397, 4405, 4422, 4491, 4496, 4512, 4519, 4583], 'antagonists': [66, 317, 2086, 3443, 3590, 3868, 4173], 'integrin,': [69, 320], 'whereas': [70, 321, 2853, 3511], 'several': [76, 327, 559, 2781, 3845], 'partially': [80, 331, 924, 3480, 3854, 3876, 4403, 4511], 'each': [83, 105, 334, 356, 2137, 2499, 2628, 3967, 4228, 4451, 4456], 'α-subunit-specific': [84, 335], 'antagonist': [85, 226, 336, 477, 1612, 1669, 3500, 3632, 3737, 3749], 'completely': [87, 338, 1115, 2961, 3037, 3394, 3640, 3882, 4420, 4518], 'combining': [90, 341, 3914], 'antagonists.': [92, 343], 'recognize': [95, 346, 749, 1025, 1198, 1226, 3147, 3451, 3703, 4541], 'both': [96, 347, 1296, 2793, 3701, 4263, 4387, 4521, 4576], 'second': [98, 349, 1244, 2974, 4246, 4265, 4600], 'third': [100, 193, 351, 444, 1246, 2833, 2957, 3839, 4248, 4267, 4271, 4602], 'repeats,': [103, 162, 354, 413, 2799], 'repeat': [108, 176, 359, 427, 580, 4452], 'shows': [109, 360], 'pan-β1': [110, 361, 3435], 'specificity': [111, 362, 1261, 3402, 3460, 4447], 'divalent': [113, 169, 364, 420, 3264, 4355, 4437], 'cation': [114, 365, 4356], 'dependence': [115, 366, 4357], 'for': [116, 152, 367, 403, 586, 1238, 2015, 2095, 2116, 2136, 2209, 2262, 2376, 2444, 2479, 2498, 2545, 2601, 2896, 2935, 2988, 3155, 3403, 3419, 3461, 3687, 3789, 3947, 4190, 4227, 4252, 4530], 'promoting': [117, 368], 'adhesion.': [119, 370], 'less': [127, 378, 2820, 2891, 2904, 4285], 'sensitive': [128, 379], 'α-subunit': [130, 381], 'antagonists,': [131, 382], 'but': [132, 383, 800, 877, 2912, 2968, 3057, 3487, 3627, 3691, 3780, 4399], 'a': [133, 168, 173, 189, 384, 419, 424, 440, 554, 584, 761, 801, 1017, 1089, 1118, 1137, 1283, 1421, 2151, 2374, 2403, 2428, 2743, 2760, 2964, 2994, 3027, 3287, 3347, 3657, 3671, 3683, 3838, 3987, 4079, 4209, 4288, 4591], 'blocking': [135, 184, 386, 435, 1288, 3042, 3440, 3587, 3977, 4492, 4497, 4513, 4520], 'antibody': [136, 185, 221, 387, 436, 472, 1019, 1418, 1423, 1477, 1506, 1525, 1562, 1579, 2405, 2763, 2810, 2946, 2966, 3043, 3273, 3350, 3399, 3659, 3881, 3917], 'two': [138, 389, 971, 3177, 4281, 4350], 'disintegrins': [139, 390, 1716], 'inhibit': [140, 391], 'expression': [149, 400, 3959], 'necessary': [151, 402, 3154, 3418], 'or': [159, 410, 1185, 1332, 1979, 2038, 2069, 2078, 2084, 2268, 2508, 2525, 2757, 2830, 3061, 3589, 3695, 4219, 4295, 4340, 4453, 4486, 4507, 4515, 4629], 'bind': [166, 417], 'cation-dependent': [170, 421], 'manner': [171, 422], 'affinity': [177, 428, 2146, 3254], 'column.': [178, 429], 'widely': [180, 431, 1284], 'used': [181, 432, 506, 1285], 'function': [183, 434, 1287], 'A4.1': [186, 197, 222, 240, 437, 448, 473, 491, 1563, 2077, 2488, 2517, 2536], 'binds': [187, 438], 'site': [190, 441, 664, 807, 4215], 'repeat.': [196, 447], 'proximally': [198, 449], 'inhibits': [199, 210, 450, 461, 1291], 'integrin-dependent': [201, 211, 452, 462, 976, 2775, 3239], 'indirectly': [209, 460], 'mediated': [213, 464, 925, 2392, 3319, 4361], 'Although': [220, 471, 957, 3941], 'also': [224, 475, 1031, 2367, 2400, 2908, 3066, 3417, 3750, 3875, 4305, 4395], 'an': [225, 476, 536, 927, 3253, 3483, 4327], 'CD36': [228, 479, 3321], 'binding': [229, 249, 480, 500, 565, 809, 880, 961, 2653, 4214, 4225, 4235, 4610], 'TSP1,': [231, 482, 1207, 1216, 2824, 4241], 'these': [232, 245, 483, 496, 985, 1179, 1263, 2873, 3280, 3775, 3948, 4177, 4280, 4636], 'data': [233, 484, 3946], 'suggest': [234, 485], 'some': [236, 487, 4426], 'biological': [237, 488], 'activities': [238, 489, 977, 4465], 'result': [241, 492, 3900], 'antagonism': [243, 494], 'novel': [246, 497], 'sites.': [250, 501, 987, 4611], 'Thrombospondin-1': [502], '(TSP1)': [503], '1The': [504], 'abbreviations': [505], 'are:': [507], 'TSP,': [508], 'thrombospondin;': [509], 'TSR,': [510], 'thrombospondin': [511], 'repeat;': [514], 'BSA,': [515, 2011], 'bovine': [516, 1802, 1875, 1931, 1966], 'serum': [517, 1932], 'albumin;': [518], 'EGF,': [519], 'epidermal': [520], 'growth': [521], 'factor;': [522], 'phLDVP,': [523], '(4-((2-methylphenyl)aminocarbonyl)-aminophenyl)acetyl-LDVP;': [524], 'PMA,': [525, 2068], 'phorbol': [526, 3031], '12-myristate': [527], '13-acetate;': [528], 'mAb,': [529], 'monoclonal': [530], 'antibody;': [531], 'TBS,': [532, 2622], 'Tris-buffered': [533, 2432], 'saline.': [534, 2124], 'extracellular': [537], 'matrix': [538, 2155], 'glycoprotein': [539], 'modulates': [541], 'adhesion,': [543], 'growth,': [544], 'motility,': [545], 'differentiation,': [546], 'survival.': [548], 'interacts': [550], 'with': [551, 1148, 1870, 1928, 1945, 2009, 2021, 2061, 2110, 2119, 2127, 2228, 2277, 2289, 2294, 2329, 2351, 2369, 2387, 2402, 2450, 2462, 2471, 2575, 2604, 2611, 3170, 3174, 3209, 3271, 3286, 3299, 3316, 3727, 3898, 4624], 'via': [553, 4543], 'number': [555], 'receptors,': [557], 'including': [558, 3848, 4085], 'integrins.': [560, 3405, 4192], 'Locations': [561], 'four': [563], 'have': [567, 965, 973, 1218, 4606, 4616], 'been': [568, 967, 4617], 'mapped': [569], 'TSP1.': [571, 758, 1190, 1233, 1255, 1299, 3429, 3865, 4297, 4315], 'RGD': [573, 1187], 'sequence': [574, 762, 929, 1188], 'last': [577], 'ligand': [585, 3213, 3758], 'αvβ3': [587], 'α5β1': [589, 4498], '(1Lawler': [591], 'J.': [592, 597, 613, 616, 648, 677, 735, 784, 830, 855, 900, 946, 1039, 1044, 1311, 1314, 1350, 1377, 1393, 1446, 1495, 1649, 1704, 1852, 1900, 2676, 2697, 2727, 3078, 3117, 3192, 3227, 3559, 3825, 4002, 4049, 4116, 4552, 4555], 'Weinstein': [593], 'R.': [594, 3817, 4041], 'Hynes': [595], 'R.O.': [596], 'Cell': [598, 649, 678, 831, 947, 1045, 1394, 1447, 1463, 2677, 3228, 4134], 'Biol.': [599, 617, 650, 679, 718, 785, 832, 856, 901, 948, 1046, 1351, 1448, 1911, 2678, 2698, 2728, 3089, 3128, 3193, 3229, 3570, 4013, 4556], '1988;': [600], '107:': [601], '2351-2361Crossref': [602], 'PubMed': [603, 627, 654, 683, 700, 723, 739, 795, 836, 866, 911, 952, 1010, 1050, 1080, 1171, 1361, 1452, 1469, 1500, 1558, 1655, 1710, 1768, 1859, 1916, 2682, 2708, 2738, 3094, 3133, 3203, 3233, 3575, 3830, 4018, 4054, 4123, 4140, 4165, 4566], 'Scopus': [604, 628, 655, 684, 701, 724, 740, 796, 837, 867, 912, 953, 1011, 1051, 1081, 1172, 1321, 1362, 1453, 1470, 1656, 1711, 1769, 1917, 2683, 2709, 2739, 3095, 3134, 3204, 3234, 3576, 3831, 4019, 4055, 4141, 4166, 4567], '(337)': [605], 'Google': [606, 630, 657, 686, 703, 726, 742, 798, 839, 869, 914, 955, 1013, 1053, 1083, 1174, 1323, 1364, 1383, 1399, 1455, 1472, 1501, 1559, 1658, 1713, 1747, 1771, 1860, 1919, 2685, 2711, 2741, 3097, 3136, 3206, 3236, 3578, 3833, 4021, 4057, 4074, 4124, 4143, 4168, 4569], 'Scholar,': [607, 631, 687, 704, 727, 840, 1365, 1384, 1456, 1748, 2686, 2712, 4058, 4125, 4144], '2Sipes': [608], 'J.M.': [609, 637, 779, 819, 844, 889, 935, 1697, 2665, 2692, 2716, 3216], 'Krutzsch': [610, 640, 711, 822, 845, 890, 938, 2668, 2717, 3223, 4065], 'H.C.': [611, 641, 712, 775, 823, 846, 891, 939, 2669, 2688, 2718, 3224, 4066], 'Lawler': [612, 1372, 1376], 'Roberts': [614, 646, 715, 782, 828, 853, 898, 944, 2674, 2695, 2725, 3225, 4067, 4553], 'D.D.': [615, 647, 716, 783, 829, 854, 899, 945, 1309, 2675, 2696, 2726, 3226, 4068, 4554], 'Chem.': [618, 786, 857, 902, 1352, 1651, 1706, 2699, 2729, 3194, 4557], '1999;': [619, 787, 1652, 1856, 2700, 4120, 4157, 4558], '274:': [620, 788, 2701, 4559], '22755-22762Abstract': [621], 'Full': [622, 624, 790, 792, 861, 863, 906, 908, 1007, 1077, 1356, 1358, 2703, 2705, 2733, 2735, 3198, 3200, 4160, 4162, 4561, 4563], 'Text': [623, 625, 791, 793, 862, 864, 907, 909, 1008, 1078, 1357, 1359, 2704, 2706, 2734, 2736, 3199, 3201, 4161, 4163, 4562, 4564], 'PDF': [626, 794, 865, 910, 1009, 1079, 1360, 2707, 2737, 3202, 4164, 4565], '(55)': [629, 3235], '3Li': [632], 'Z.': [633, 815, 931, 2661], 'Calzada': [634, 816, 932, 2662], 'M.J.': [635, 817, 842, 887, 933, 2663, 2714], 'Sipes': [636, 778, 818, 843, 888, 934, 2664, 2691, 2715], 'Cashel': [638, 820, 936, 1310, 2666], 'J.A.': [639, 821, 937, 2667], 'Annis': [642, 824, 849, 894, 940, 1346, 1387, 2670, 2721], 'D.': [643, 825, 941, 1041, 1761, 1845, 1851, 2671, 4109, 4115], 'Mosher': [644, 675, 826, 851, 896, 942, 1348, 1389, 2672, 2723], 'D.F.': [645, 676, 827, 852, 897, 943, 1349, 1390, 2673, 2724], '2002;': [651, 833, 949, 1168, 1396, 2679, 4071], '157:': [652, 834, 950, 2680], '509-519Crossref': [653, 835, 951, 2681], '(121)': [656, 838, 954, 2684], 'Scholar),': [658, 799, 1054, 2742, 3137, 3207, 3237, 4169], 'although': [659, 2872, 3539, 4269], 'exposure': [661], 'this': [663, 806, 882, 1124, 1230, 2377, 2412, 2840, 2851, 2979, 3334, 3354, 3652, 3899, 4334], 'native': [666], 'may': [668, 3530, 4325], 'be': [669, 982, 3245, 3323, 3953, 4205, 4326, 4338, 4581], 'limited': [670, 1146, 2881, 3988, 4331], '(4Sun': [671], 'X.': [672], 'Skorstengaard': [673], 'K.': [674, 1616], '1992;': [680], '118:': [681], '693-701Crossref': [682], '(93)': [685], '5Hotchkiss': [688], 'K.A.': [689], 'Matthias': [690], 'L.J.': [691], 'Hogg': [692], 'P.J.': [693, 1839, 1904, 3082, 3121, 3563, 4006, 4103], 'Biochim.': [694], 'Biophys.': [695, 1165], 'Acta.': [696], '1998;': [697, 1913, 3091, 3130, 3572, 4015, 4137], '1388:': [698], '478-488Crossref': [699], '(68)': [702, 4167], '6Chandrasekaran': [705], 'L.': [706, 1549, 4062], 'He': [707], 'C.-Z.': [708], 'Al-Barazi': [709], 'H.O.': [710, 4060], 'Iruela-Arispe': [713], 'M.L.': [714], 'Mol.': [717, 1910, 3088, 3127, 3569, 4012], 'Cell.': [719, 1912, 3090, 3129, 3571, 4014], '2000;': [720, 1353, 3195, 3827, 4051], '11:': [721], '2885-2900Crossref': [722], '(141)': [725], '7Kvansakul': [728], 'M.': [729, 1371, 1835, 1843, 3807, 3809, 4031, 4033, 4099, 4107], 'Adams': [730, 1391, 1647], 'J.C.': [731, 1392], 'Hohenester': [732], 'E.': [733, 1841, 1902, 3080, 3119, 3220, 3561, 4004, 4105], 'EMBO': [734], '2004;': [736, 1765], '23:': [737], '1223-1233Crossref': [738], '(127)': [741], 'Scholar).': [743, 870, 915, 956, 1084, 1175, 1324, 1400, 1473, 1560, 1714, 1772, 3098, 3579, 3834, 4075, 4570], 'At': [744, 2814], 'least': [745, 923, 970, 3176, 4585, 4598], 'distinct': [750, 4224], 'N-terminal': [754, 3517], 'pentraxin-like': [755], 'domain': [756], 'α3β1': [759, 1197, 1225, 3624, 3636, 3765, 3796, 4026, 4516, 4544], 'recognizes': [760], 'near': [763], 'carboxyl': [765], 'end': [766], 'containing': [770, 1095, 1327, 1799, 1963, 2176, 2231, 2363, 2828, 3017, 3376, 4290], 'motif': [772], 'NVR': [773], '(8Krutzsch': [774], 'Choe': [776, 2689], 'B.': [777, 1755, 1831, 1833, 1849, 2690, 4095, 4097, 4113], 'Guo': [780, 1312, 2693, 3217, 4547], 'N.': [781, 1313, 1386, 2694, 3218, 3811, 4035, 4548], '24080-24086Abstract': [789, 2702], '(71)': [797, 2710], 'truncated': [802], 'recombinant': [803, 1213, 1970, 2483, 2750, 4242], 'lacking': [805, 3108], 'retains': [808], 'α6β1': [811, 876], 'α4β1': [813, 879, 1195, 1223, 1610, 3484, 3540, 3631, 3757, 3870, 3991, 4493], '(3Li': [814, 930, 2660], '9Calzada': [841, 2713], 'Yurchenco': [847, 892, 2719], 'P.D.': [848, 893, 2720], 'D.S.': [850, 895, 1347, 1388, 2722], '2003;': [858, 903, 1744, 2730], '278:': [859, 904, 2731], '40679-40687Abstract': [860, 905, 2732], '(86)': [868, 913, 2740], 'Mutation': [871], 'Glu': [873], '(90)': [874], 'abolishes': [875], 'not': [878, 2391, 2876, 2914, 2931, 2949, 3058, 3146, 3329, 3352, 3361, 3628, 3654, 3692, 3781, 3895, 4528], 'region': [883, 1205, 1231, 3518], '(9Calzada': [886], 'Binding': [916], 'latter': [919, 3034], 'at': [922, 969, 1942, 1997, 2051, 2087, 2098, 2205, 2265, 2270, 2447, 2618, 2634, 2837, 2850, 2916, 3175, 4584, 4597], 'LDVP': [928], 'now': [966, 1219], 'described,': [968], 'publications': [972, 1192], 'noted': [974, 1087, 2934], 'cannot': [981], 'explained': [983, 4206], 'DeFreitas': [988], 'et': [989], 'al.': [990], '(11DeFreitas': [991, 1061], 'M.F.': [992, 1062], 'Yoshida': [993, 1063], 'C.K.': [994, 1064, 1701], 'Frazier': [995, 1042, 1065, 1569], 'W.A.': [996, 1043, 1066], 'Mendrick': [997, 1067], 'D.L.': [998, 1068], 'Kypta': [999, 1069], 'R.M.': [1000, 1070, 1679], 'Reichardt': [1001, 1071], 'L.F.': [1002, 1072], 'Neuron.': [1003, 1073], '1995;': [1004, 1074, 1466], '15:': [1005, 1075], '333-343Abstract': [1006, 1076], '(149)': [1012, 1082], 'Scholar)': [1014, 1502, 1659, 1861, 1920, 4022], 'report': [1015, 1235], '(A4.1),': [1020], 'which': [1021, 1113, 2800, 3064, 3172, 3293, 3448, 3710, 3760, 4538], 'was': [1022, 1114, 1126, 1155, 1303, 1405, 1527, 1564, 1581, 1660, 1671, 1958, 1983, 2148, 2214, 2225, 2255, 2275, 2307, 2390, 2422, 2501, 2518, 2586, 2625, 2632, 2801, 2941, 2960, 2976, 3005, 3021, 3036, 3101, 3337, 3393, 3410, 3468, 3479, 3619, 3653, 3668, 3721, 3761, 3974, 4273, 4394, 4401, 4413, 4419, 4488, 4509, 4527], 'believed': [1023], '(TSR,': [1030], 'as': [1033, 1340, 1726], 'properdin': [1034], 'repeats)': [1035], '(10Prater': [1036], 'C.A.': [1037], 'Plotkin': [1038], 'Jaye': [1040], '1991;': [1047], '112:': [1048], '1031-1040Crossref': [1049], '(188)': [1052], 'α3β1-dependent': [1056], 'neurite': [1057, 1111], 'outgrowth': [1058], 'They': [1085], 'further': [1086, 1280, 3138, 4231], '50/70-kDa': [1090], 'chymotryptic': [1091], 'fragment': [1092, 1141, 4335], 'procollagen': [1097], 'domain,': [1098], 'TSRs,': [1101, 2993, 3538, 4268], 'part': [1103], 'EGF-like': [1106, 3426], 'supported': [1110, 2818, 2835], 'outgrowth,': [1112], 'antibody.': [1120, 2372, 2980, 3730], 'Approximately': [1121], '80%': [1122], 'response': [1125, 3035], 'α3β1-specific': [1129], 'antibodies.': [1130], 'Furthermore,': [1131], 'osteosarcoma': [1134], 'similar': [1138, 2864], '70-kDa': [1139], 'core': [1140], 'produced': [1144, 1509, 3682], 'proteolysis': [1147], 'chymotrypsin': [1149], 'absence': [1152, 2756, 3742, 4300, 4317], 'calcium': [1154], 'α4β1-dependent': [1156], '(12Decker': [1157], 'S.': [1158, 1460, 1547, 1632, 1751, 3815, 4039, 4546], 'van': [1159], 'Valen': [1160], 'F.': [1161, 1482, 3813, 4037, 4150], 'Vischer': [1162], 'P.': [1163, 1373], 'Biochem.': [1164], 'Res.': [1166, 1379, 1743, 4070], 'Commun.': [1167, 1465, 4136], '293:': [1169], '86-92Crossref': [1170], '(21)': [1173], 'Notably,': [1176, 3580, 3793], 'none': [1177, 3581], 'proteolytic': [1180], 'fragments': [1181, 2485], 'contain': [1182, 2773], 'These': [1191], 'suggested': [1193], 'additional': [1199, 3527], 'central': [1203], 'stalk': [1204], 'possibly': [1208], 'TSRs.': [1211, 3149, 3161, 3705, 3792, 3940, 4181], 'Using': [1212], 'regions': [1214, 2751, 2856], 'verified': [1220], 'activated': [1222], 'secondary': [1227], 'We': [1234, 1279], 'here': [1236], 'evidence': [1237], 'such': [1240], 'TSRs': [1247, 2386, 2911, 3020, 3165, 3243, 3318, 3453, 3618, 3973, 4186, 4218, 4239, 4249, 4282, 4293, 4352, 4603, 4621], 'However,': [1256, 3247, 3706, 3878, 4279], 'find': [1258], 'differs': [1265], 'those': [1267], 'most': [1269, 2790, 3543, 3799, 3979, 4171], 'previously': [1270, 2226], 'described': [1271, 1341, 1727], 'they': [1276], 'are': [1277, 2986, 3053, 3065, 3153, 3166, 3416, 3783, 3797, 4187], 'show': [1281], 'antibody,': [1289, 2065, 3651], 'A4.1,': [1290], 'Proteins': [1300], 'Peptides—TSP1': [1302], 'purified': [1304], 'human': [1306, 1778, 2047], 'platelets': [1307], '(13Roberts': [1308], 'Tissue': [1315], 'Cult.': [1316], 'Methods.': [1317], '1994;': [1318, 1555], '16:': [1319], '217-222Crossref': [1320], '(44)': [1322], 'Recombinant': [1325], 'proteins': [1326, 1971, 3277], 'various': [1328, 3963], 'domains': [1329], 'TSP2': [1333], '(summarized': [1334, 1975], 'Fig.': [1336, 1977], '1A)': [1337], 'were': [1338, 1425, 1508, 1603, 1724, 1782, 1795, 1862, 1921, 1940, 2002, 2007, 2019, 2059, 2091, 2106, 2130, 2166, 2324, 2338, 2356, 2366, 2399, 2442, 2459, 2489, 2533, 2543, 2566, 2571, 2847, 2859, 2862, 3259, 3444, 3493, 3874, 3911, 4250, 4284], 'prepared': [1339, 1725, 2149], '(14Misenheimer': [1342], 'T.M.': [1343], 'Huwiler': [1344], 'K.G.': [1345], '275:': [1354, 3196], '40938-40945Abstract': [1355], '(40)': [1363, 1918, 3096, 3135, 3577, 4020], '15Miao': [1366], 'W.M.': [1367, 1642], 'Seng': [1368], 'W.L.': [1369], 'Duquette': [1370], 'Laus': [1374], 'C.': [1375, 1683, 1729, 1763, 1837, 4101], 'Cancer': [1378, 1742, 4069], '2001;': [1380], '61:': [1381], '7830-7839PubMed': [1382], '16Anilkumar': [1385], 'Sci.': [1395], '115:': [1397], '2357-2366PubMed': [1398], 'Vitrogen': [1401], 'I': [1403, 1981, 3666, 3697, 4410], 'collagen': [1404, 1982, 3667, 4411], 'Cohesion': [1407], 'Technologies': [1408], '(Palo': [1409], 'Alto,': [1410], 'CA).': [1411, 1608, 1665], 'Antibodies': [1412, 3843], 'Antagonists—A': [1414], 'function-blocking': [1417, 1589, 3625], '(mAb13)': [1419], 'fibronectin': [1422, 2404, 3214, 3338, 3349], '(13G12)': [1424, 2406], 'provided': [1426, 1528, 1565, 1672], 'Dr.': [1428, 1530, 1567, 1674], 'Ken': [1429], 'Yamada': [1430, 1440, 1444, 1461], '(NIDCR,': [1431], 'National': [1432], 'Institutes': [1433], 'Health,': [1435], 'Bethesda,': [1436], 'MD)': [1437], '(17Akiyama': [1438], 'S.K.': [1439, 1458], 'S.S.': [1441], 'Chen': [1442, 1633], 'W.T.': [1443], 'K.M.': [1445, 1462, 1538], '1989;': [1449], '109:': [1450], '863-875Crossref': [1451], '(511)': [1454], '18Akiyama': [1457], 'Aota': [1459], 'Adhes.': [1464, 4135], '3:': [1467], '13-25Crossref': [1468], '(58)': [1471], 'integrin-activating': [1476, 2762], 'TS2/16': [1478, 2064, 2811, 2947, 3024, 3367, 4257], '(19Hemler': [1479], 'M.E.': [1480], 'Sanchez-Madrid': [1481], 'Flotte': [1483], 'T.J.': [1484], 'Krensky': [1485], 'A.M.': [1486], 'Burakoff': [1487], 'S.J.': [1488], 'Bhan': [1489], 'A.K.': [1490], 'Springer': [1491], 'T.A.': [1492], 'Strominger': [1493], 'J.L.': [1494], 'Immunol.': [1496], '1984;': [1497], '132:': [1498], '3011-3018Crossref': [1499], 'anti-TSP1': [1505], 'HB8432': [1507], 'hybridoma': [1511], 'lines': [1513, 3951], 'obtained': [1514, 1582, 1604, 1661, 1783], 'American': [1517], 'Type': [1518, 1955, 3431], 'Culture': [1519, 1956], 'Collection': [1520], '(Manassas,': [1521], 'VA).': [1522], 'anti-α2': [1524], '6D7': [1526], 'Harvey': [1531], 'Gralnick': [1532, 1550], '(20Saelman': [1533], 'E.U.': [1534], 'Nieuwenhuis': [1535], 'H.K.': [1536], 'Hese': [1537], 'de': [1539], 'Groot': [1540], 'P.G.': [1541, 3187, 3821, 4045], 'Heijnen': [1542], 'H.F.': [1543], 'Sage': [1544], 'E.H.': [1545], 'Williams': [1546], 'McKeown': [1548], 'H.R.': [1551], 'Sixma': [1552], 'J.J.': [1553, 1733, 1759], 'Blood.': [1554], '83:': [1556], '1244-1250Crossref': [1557], 'Bill': [1568], '(Washington': [1570], 'University': [1571], 'School': [1572], 'Medicine,': [1574], 'St.': [1575], 'Louis,': [1576], 'MO).': [1577], '5G11': [1580], 'Biodesign': [1584], 'International': [1585], '(Saco,': [1586], 'ME).': [1587], 'antibodies': [1591, 2076, 3441, 3588, 3626, 3639], 'FB12': [1592], '(anti-α1),': [1593], 'P1B5': [1594], '(anti-α3),': [1595], 'P4C2': [1596], '(anti-α4),': [1597], 'P1D6': [1598], '(anti-α5),': [1599], 'GoH3': [1601], '(anti-α6)': [1602], 'Chemicon': [1606], '(Temecula,': [1607], '(4-((2-methylphenyl)aminocarbonyl)aminophenyl)acetyl-LDVP': [1613], '(phLDVP)': [1614], '(21Lin': [1615], 'Ateeq': [1617], 'H.S.': [1618], 'Hsiung': [1619], 'S.H.': [1620], 'Chong': [1621], 'L.T.': [1622], 'Zimmerman': [1623], 'C.N.': [1624], 'Castro': [1625], 'A.': [1626, 1644, 3823, 4047, 4146], 'Lee': [1627], 'W.C.': [1628], 'Hammond': [1629], 'C.E.': [1630, 1695], 'Kalkunte': [1631], 'L.L.': [1634], 'Pepinsky': [1635], 'R.B.': [1636, 4154], 'Leone': [1637], 'D.R.': [1638, 3185], 'Sprague': [1639], 'A.G.': [1640], 'Abraham': [1641], 'Gill': [1643], 'Lobb': [1645, 1740], 'R.R.': [1646, 1689, 1741], 'S.P.': [1648], 'Med.': [1650, 1705], '42:': [1653], '920-934Crossref': [1654], '(208)': [1657], 'Bachem': [1663], '(Torrance,': [1664], 'αv': [1667, 3491, 3872, 3920], 'SB223245': [1670], 'William': [1675], 'Miller': [1676, 1680], '(GlaxoSmithKline)': [1677], '(22Keenan': [1678], 'W.H.': [1681], 'Kwon': [1682], 'Ali': [1684], 'F.E.': [1685], 'Callahan': [1686], 'J.F.': [1687, 3183], 'Calvo': [1688], 'Hwang': [1690], 'S.M.': [1691], 'Kopple': [1692], 'K.D.': [1693], 'Peishoff': [1694], 'Samanen': [1696], 'Wong': [1698], 'A.S.': [1699], 'Yuan': [1700], 'Huffman': [1702], 'W.F.': [1703], '1997;': [1707], '40:': [1708], '2289-2292Crossref': [1709], '(129)': [1712], 'VLO-5': [1717], '(α4/α9': [1718], 'integrin-specific)': [1719, 1723], 'obtustatin': [1721], 'α1β1': [1722], '(23Marcinkiewicz': [1728], 'Weinreb': [1730], 'P.H.': [1731], 'Calvete': [1732, 1758], 'Kisiel': [1734, 1752], 'D.G.': [1735, 1753], 'Mousa': [1736], 'S.A.': [1737], 'Tuszynski': [1738], 'G.P.': [1739], '63:': [1745], '2020-2023PubMed': [1746], '24Bazan': [1749], 'Socha': [1750], 'Young': [1754], 'Theakston': [1756], 'R.D.': [1757], 'Sheppard': [1760], 'Marcinkiewicz': [1762], 'Biochemistry.': [1764], '43:': [1766], '1639-1647Crossref': [1767], '(47)': [1770], 'Cells—Human': [1773], 'umbilical': [1774, 1791, 2043], 'vein': [1775, 1792, 2044], 'endothelial': [1776, 1793, 1809, 2045, 2953], 'dermal': [1779, 2048], 'microvascular': [1780, 2049], 'Clonetics': [1785], 'BioWhittaker': [1786], 'Inc.': [1787], '(Walkersville,': [1788], 'MD).': [1789], 'Human': [1790, 1827], 'maintained': [1796, 1863, 1922, 1959], 'M199': [1798], '20%': [1800], 'fetal': [1801, 1874, 1930, 1965], 'serum,': [1803, 1876], 'mm': [1805, 1935, 2023, 2071, 2180, 2185, 2188, 2191, 2195, 2235, 2240, 2243, 2246, 2250, 2296, 2318, 4369, 4377], 'glutamine,': [1806], '80': [1807], 'μg/ml': [1808, 1818, 1825, 1882, 2063, 2520], 'mitogen': [1811], '(Biomedical': [1812], 'Technologies,': [1813], 'Inc.,': [1814], 'Stoughton,': [1815], 'MA),': [1816], '10': [1817, 2221, 4376], 'heparin,': [1819], '50': [1820, 1824, 1877, 1881, 2179, 2234, 2451], 'units/ml': [1821, 1878], 'penicillin,': [1822, 1879], 'streptomycin.': [1826, 1883], 'mesangial': [1828, 2785, 3856, 3934, 4259, 4303, 4380, 4427], '(25Banas': [1830, 4094], 'Luckow': [1832, 4096], 'Moller': [1834, 4098], 'Klier': [1836, 4100], 'Nelson': [1838, 4102], 'Schadde': [1840, 4104], 'Brigl': [1842, 4106], 'Halevy': [1844, 4108], 'Holthofer': [1846, 4110], 'H.': [1847, 4111, 4148], 'Reinhart': [1848, 4112], 'Schlondorff': [1850, 4114], 'Am.': [1853, 4117], 'Soc.': [1854, 4118], 'Nephrol.': [1855, 4119], '10:': [1857, 4121], '2314-2322Crossref': [1858, 4122], "Dulbecco's": [1865, 2012, 2111, 2122], 'modified': [1866], "Eagle's": [1867], 'medium': [1868, 1926], 'supplemented': [1869, 1927], 'Glutamax': [1871], '(Invitrogen),': [1872], '10%': [1873, 1929, 1964], 'Jurkat': [1884, 2161, 2396, 2867, 2998, 3013, 3069, 3295, 3326, 3344, 3370, 3407, 3471, 3549, 3596, 3993, 4481], 'T': [1885, 2868, 3156, 3371, 3422, 3533, 3550, 3609, 3712, 4470, 4482], 'integrin-deficient': [1890], 'mutant': [1891, 2996, 3107, 3409], 'A1': [1892, 3105, 3408], '(26Romzek': [1893, 3071, 3110, 3552, 3995], 'N.C.': [1894, 3072, 3111, 3553, 3996], 'Harris': [1895, 3073, 3112, 3554, 3997], 'E.S.': [1896, 3074, 3113, 3555, 3998], 'Dell': [1897, 3075, 3114, 3556, 3999], 'C.L.': [1898, 3076, 3115, 3557, 4000], 'Skronek': [1899, 3077, 3116, 3558, 4001], 'Hasse': [1901, 3079, 3118, 3560, 4003], 'Reynolds': [1903, 3081, 3120, 3562, 4005], 'Hunt': [1905, 3083, 3122, 3564, 4007], 'III,': [1906, 3084, 3123, 3565, 4008], 'S.W.': [1907, 3085, 3124, 3566, 4009], 'Shimizu': [1908, 3086, 3125, 3567, 4010], 'Y.': [1909, 3087, 3126, 3568, 4011, 4131], '9:': [1914, 3092, 3131, 3573, 4016], '2715-2727Crossref': [1915, 3093, 3132, 3574, 4017], 'RPMI': [1924, 1961], '1640': [1925, 1962], 'glutamine.': [1936], 'All': [1937], 'cultures': [1939], 'grown': [1941], '37': [1943, 2099], '°C': [1944, 2100, 2449], '5%': [1946, 2102, 2472], 'CO2.': [1947], 'breast': [1949, 3612, 3768, 4473], 'carcinoma': [1950, 3613, 3769, 4474], 'line': [1952], 'MDA-MB-231': [1953, 2034, 3611, 3642, 3787, 3804, 4028, 4503, 4539], '(American': [1954], 'Collection)': [1957], 'serum.': [1967], 'Assays—TSP1,': [1969], 'derived': [1972], '1A),': [1978], 'adsorbed': [1984], '(triplicates': [1985], '8-μl': [1987], 'drops)': [1988], 'onto': [1989], 'polystyrene': [1990], 'dishes': [1991, 2006, 2105], '(Falcon': [1992], '1008)': [1993], 'incubating': [1995], 'overnight': [1996, 2269], '4': [1998, 2271, 2448, 2573, 2609], '°C.': [1999, 2272], 'drops': [2001], 'removed,': [2003, 2567], 'blocked': [2008, 2470, 2553, 3038], '1%': [2010, 2120, 2477], 'phosphate-buffered': [2013, 2112, 2123], 'saline': [2014, 2113, 2433], '30': [2016, 2117], 'min.': [2017], 'Cells': [2018], 'dissociated': [2020], 'EDTA': [2024, 4378], 'PBS': [2026], 'resuspended': [2028], 'RPMI,': [2030], '0.1%': [2031, 2040, 2592], 'BSA': [2032, 2041, 2478, 2598], '(Jurkat,': [2033], 'messangial': [2036], 'cells)': [2037, 2050], 'M199,': [2039], '(human': [2042], '5': [2052], '×': [2053, 2164, 2207], '106': [2054], 'cells/ml.': [2055], 'For': [2056, 2073], 'activation': [2057, 2804], 'treated': [2060], '5–10': [2062, 2172], '20': [2066, 2210, 2467], 'ng/ml': [2067], '0.1': [2070, 2245], 'MnCl2.': [2072, 2251], 'inhibition': [2074, 3904], 'HB8432,': [2079], 'specific': [2080, 3348, 3584, 3684], 'α': [2081], 'integrin-blocking': [2082], 'antibodies,': [2083, 3680], 'indicated': [2089], 'concentrations': [2090, 2497], 'used.': [2092], 'After': [2093, 2125, 2198, 2558, 2607], 'incubation': [2094], 'h': [2097, 2264, 2446, 2547, 2560, 2603], 'CO2,': [2103], 'washed': [2107, 2227, 2276, 2287, 2460, 2555, 2572], '3': [2108], 'times': [2109, 2574, 2610], 'fixed': [2115], 'min': [2118], 'glutaraldehyde,': [2121], 'staining': [2126], 'Diff-Quik,': [2128], 'counted': [2131], 'microscopically': [2132], '0.25-mm2': [2134], 'fields': [2135], 'triplicate': [2138], 'analysis.': [2139], 'Integrin': [2140, 3436], 'Purification': [2141], 'TSR': [2143, 2834, 2958, 2975, 4272, 4457], 'Affinity—A': [2144], 'TSR123': [2145, 3016, 3257, 3690, 4393, 4418], 'column': [2147, 2224, 2259, 2274, 2311, 3255], 'using': [2150, 2219, 2808, 2865, 3346], 'CNBr-activated': [2152], 'agarose': [2153], 'bead': [2154], '(following': [2156], "manufacturer's": [2158], 'protocol).': [2159], 'Surface-biotinylated': [2160], '(2–5': [2163], '108)': [2165], 'lysed': [2167], 'presence': [2170, 2410, 2758, 4222], 'ml': [2173, 2218], 'buffer': [2175, 2230, 2279, 2291, 2293, 2315], '100': [2177], 'mmn-octylglucoside,': [2178, 2233], 'Tris-HCl,': [2181, 2236], 'pH': [2182, 2237, 2623], '7.4,': [2183, 2238], '150': [2184, 2239], 'NaCl,': [2186, 2241], 'MgCl2,': [2189, 2244], 'CaCl2,': [2192, 2247], 'phenylmethylsulfonyl': [2196], 'fluoride.': [2197], 'removal': [2199], 'insoluble': [2201], 'material': [2202], 'centrifugation': [2204], '3000': [2206], 'g': [2208], 'min,': [2211], 'extract': [2213, 2254], 'concentrated': [2215], 'Centripep': [2220], '(Millipore).': [2222], 'equilibration': [2229, 2278], '25': [2232], '0.5': [2249], 'applied': [2256], 'incubated': [2261, 2350, 2544, 2600], 'room': [2266], 'temperature': [2267], 'until': [2280, 2298], 'protein': [2281, 2299, 2413, 3355, 3718], 'disappeared': [2282, 2300], 'eluate,': [2285], 'then': [2286], 'again': [2288], 'washing': [2290, 2314, 2608], '(equilibration': [2292], '300': [2295], 'NaCl)': [2297], 'eluate.': [2303], 'Finally,': [2304], 'eluted': [2308, 3261, 3278], 'adding': [2313], 'plus': [2316, 2435, 2464, 2591], '15': [2317], 'EDTA.': [2319, 4406], 'Fractions': [2320], '200–300': [2322], 'μl': [2323, 2331], 'collected': [2325], '1.5-ml': [2327], 'tubes': [2328], '6': [2330], 'm': [2334], 'MgCl2.': [2335], 'fractions': [2337, 2362], 'resolved': [2339], 'SDS-polyacrylamide': [2341], 'gel': [2342], 'electrophoresis,': [2343], 'transferred': [2344], 'into': [2345], 'polyvinylidene': [2346], 'difluoride': [2347], 'membrane,': [2348], 'streptavidin-horseradish': [2352], 'peroxidase.': [2353], 'Protein': [2354], 'bands': [2355], 'detected': [2357], 'chemiluminescence': [2359], '(Pierce).': [2360], 'immunoprecipitated': [2368, 2401], 'anti-β1': [2370], 'As': [2373, 2933], 'control': [2375], 'experiment': [2378], 'assure': [2381], 'interaction': [2384, 3313], 'fibronectin,': [2394], 'surface-biotinylated': [2395], 'lysates': [2398], 'determine': [2408, 3447, 4440, 4632], 'lysates.': [2417], 'Competition': [2418], 'Enzyme-linked': [2419], 'Immunosorbent': [2420], 'Assay—TSP1': [2421], 'diluted': [2423, 2455, 2490, 2587], '0.005': [2425], 'μm': [2426, 2522, 2527], 'subunit': [2429], 'basis': [2430], '(TBS)': [2434], '2mm': [2436], 'calcium,': [2437], 'Probind': [2439], '96-wellmicrotiter': [2440], 'plates': [2441, 2458], 'coated': [2443], '16': [2445], 'μl/well': [2452], 'solution.': [2456], 'once': [2461], 'TBS': [2463], '0.05%': [2465], 'Tween': [2466], '(TBST)': [2468], 'nonfat': [2473, 2593], 'dried': [2474, 2594], 'milk': [2475, 2595], 'h.': [2481], 'TSP': [2484], '(competitors)': [2486], 'so': [2491], 'when': [2493], 'combined': [2494], 'final': [2496, 2513], 'competitor': [2500], '3.0,': [2502], '1.0,': [2503], '0.3,': [2504], '0.1,': [2505], '0.03,': [2506], '0.01,': [2507], '0': [2509], 'μm,': [2510], 'concentration': [2514, 3660, 4332], '3.0': [2519], '(∼0.003': [2521], 'IgM': [2523, 2528, 2581], 'pentamer': [2524], '0.03': [2526], 'Fab': [2529], 'segment).': [2530], 'competitors': [2532], 'added': [2534, 2550, 2626], 'microcentrifuge': [2538], 'tubes,': [2539], 'mixtures': [2542, 2565], 'before': [2548], 'being': [2549], 'TSP1-coated': [2556], 'plates.': [2557], 'wells,': [2563], 'wells': [2570], 'TBST.': [2576], 'Alkaline': [2577], 'phosphatase-conjugated': [2578], 'goat': [2579], 'anti-mouse': [2580], '(μ': [2582], 'chain-specific)': [2583], 'Sigma': [2585, 2613], '1:3000': [2588], 'TBST': [2590], '0.02%': [2597], 'plate.': [2606], 'TBST,': [2612], '104': [2614], 'alkaline': [2615], 'phosphatase': [2616], 'substrate': [2617], 'mg/ml': [2620], '9.0,': [2624], 'well.': [2629], 'Color': [2630], 'development': [2631], 'monitored': [2633], '405': [2635], 'nm.': [2636], 'Three': [2637], 'Domains': [2638], 'Are': [2641, 3434, 4197], 'Recognized': [2642, 4198], 'Integrins—In': [2645], '8Krutzsch': [2687], 'survey': [2744], 'other': [2749, 2937, 4625], 'revealed': [2764], '(Fig.': [2778, 2812, 2870, 2924, 3007, 3045, 3266, 3384, 3454, 3495, 3604, 3633, 3719, 3771, 3841, 3885, 4255, 4277, 4363, 4476, 4499, 4523], '1).': [2779], 'Of': [2780], 'types': [2783], 'examined,': [2784], 'attached': [2787], 'spread': [2789, 2877], 'avidly': [2791], 'type1': [2795], 'enhanced': [2802], 'after': [2803], '1B).': [2813], 'equimolar': [2815], 'concentrations,': [2816], 'NoC1': [2817, 2888, 3694], 'slightly': [2819], 'than': [2822, 2893, 3523, 4287, 4416], 'intact': [2823, 2894, 4296, 4314], 'constructs': [2827], 'all': [2829, 3002, 3018, 3931, 4291], 'only': [2831, 4402], '∼50%': [2838, 3893], 'level.': [2841], 'alone': [2846, 4283], 'weakly': [2848, 4495], 'active': [2849, 2892, 4276, 4286], 'concentration,': [2852], 'C-terminal': [2855], 'inactive.': [2860], 'Results': [2861], 'qualitatively': [2863], 'TS2/16-activated': [2866], '1C),': [2871], 'do': [2875, 3145, 3328], 'due': [2878, 3655, 3740], 'their': [2880, 4464], 'cytoplasmic': [2882], 'volume.': [2883], 'Dose-response': [2884], 'curves': [2885], 'showed': [2886, 3724, 4306], '∼3-fold': [2890], 'mediating': [2897], 'attachment,': [2899], 'CTSR123': [2901], '13-fold': [2903], 'active.': [2905], 'Endothelial': [2906], 'recognized': [2909, 3054, 3762, 4582], 'did': [2913, 3351], 'adhere': [2915], 'significant': [2917, 4307], 'levels': [2918, 3332, 3960], '1,': [2925], 'D': [2926], 'E,': [2928], 'results': [2930, 4203, 4454], 'shown).': [2932, 2950, 3362, 3896], 'types,': [2939], 'stimulated': [2942, 3022, 4258], '(results': [2948, 3894], '(TSR3)': [2959], 'β1-blocking': [2965], '(mAb13),': [2967], '30–50%': [2969], 'resistant': [2977], 'To': [2981, 4230, 4439, 4631], 'verify': [2982], 'required': [2987], 'somatic': [2995, 3106], 'deficient': [3000], 'examined': [3006], '2).': [3008], 'wild': [3011], 'lesser': [3028], 'extent': [3029], 'ester.': [3032], 'β1-specific': [3041], 'mAb13': [3044, 3592], '2A),': [3046], 'indicating': [3047, 3139, 3401], 'β2': [3060, 3141], 'β7': [3062, 3143], 'integrins,': [3063, 3847, 3908, 4084, 4461], 'expressed': [3067, 3547, 3802], 'Activation-dependent': [3099], 'absent': [3102], 'Therefore,': [3150, 3922], 'Because': [3162], 'interact': [3169, 4623], 'CD36,': [3171], 'associates': [3173, 3297], '(27Thorne': [3180], 'R.F.': [3181], 'Marshall': [3182], 'Shafren': [3184], 'Gibson': [3186], 'Hart': [3188], 'I.R.': [3189], 'Burns': [3190], 'G.F.': [3191], '35264-35275Abstract': [3197], '(79)': [3205], '(28Sipes': [3215], 'Negre': [3219], 'Vogel': [3221], 'T.': [3222], '1993;': [3230], '121:': [3231], '469-477Crossref': [3232], 'could': [3244, 4204, 4337], 'indirect.': [3246], 'detergent-solubilized': [3248], 'bound': [3251], 'chelating': [3263], 'cations': [3265], '2B).': [3267], 'Based': [3268, 3773, 4571], 'immunoprecipitation': [3270, 3341], 'TS2/16,': [3274], 'major': [3276], 'under': [3279, 3309], 'conditions': [3281], 'corresponded': [3282], 'molecular': [3288], 'mass': [3289], 'around': [3290], '130': [3291], 'kDa,': [3292, 3307], 'primarily': [3298], 'α4': [3300, 3499, 3708, 3736, 3744, 3748], 'α5': [3302], 'subunits': [3303], '(140': [3304], '135': [3306], 'respectively,': [3308], 'reducing': [3310], 'conditions).': [3311], 'Indirect': [3312], 'can': [3322, 3952], 'excluded': [3324], 'because': [3325, 3340, 3661, 3746], 'detectable': [3331], 'receptor.': [3335], 'Neither': [3336, 3635], 'involved,': [3339], 'biotinylated': [3343], 'detect': [3353], 'lysate': [3359], '(data': [3360], 'Phorbol': [3363], 'ester': [3364], 'treatment': [3365], 'similarly': [3368], 'induced': [3369], 'E123,': [3375], '2C).': [3385], 'PMA-stimulated': [3386], 'mAb13,': [3400], 'inactive,': [3411], 'demonstrating': [3412], 'Repeats': [3433], 'Ligands—Several': [3437], 'αβ1': [3438], 'dimer-specific': [3439], 'tested': [3445, 4251, 4339], '3).': [3455], 'Remarkably,': [3456], 'type-specific.': [3470], 'antagonist,': [3486, 3709], 'α3,': [3488], 'α2,': [3489], 'inhibitors': [3492], 'inactive': [3494, 3722], '3A).': [3496, 3605], 'potent': [3498], 'phLDVP': [3501], '∼40%,': [3510], 'it': [3512], 'more': [3522, 4275], '80%,': [3524], 'suggesting': [3525, 3699, 4424], 'contribute': [3531, 3932, 4640], 'abundant': [3544, 3800, 3980], 'except': [3591], 'significantly': [3593], 'activation-dependent': [3595], 'contrast': [3607], 'cells,': [3610], 'attachment': [3615, 3663, 3891, 4385, 4400, 4429], 'α2β1': [3622, 3638, 3650, 3729, 3777, 3794, 3916, 4024, 4514], '3B).': [3634, 3772], 'nor': [3637], 'attachment.': [3644], 'case': [3647], 'limiting': [3658], 'much': [3672], 'greater': [3673], 'extent.': [3674], 'Combining': [3675], 'α2': [3677], 'α3': [3679], 'however,': [3681], 'additive': [3685, 3909], 'effect': [3686, 3753], 'collagen,': [3698], 'same': [3717, 4534], '3A),': [3720], 'no': [3725, 3752], 'additivity': [3726, 4526], 'Lack': [3731], 'activity': [3733, 4254], 'presumably': [3738], 'expression,': [3745], 'had': [3751], 'NoC1,': [3759, 4537], 'exclusively': [3763, 4542], 'results,': [3776], 'α3β1,': [3779, 3851, 3925, 4088], 'α4β1,': [3782, 3926], 'receptors': [3785], '(29Morini': [3806, 4030], 'Mottolese': [3808, 4032], 'Ferrari': [3810, 4034], 'Ghiorzo': [3812, 4036], 'Buglioni': [3814, 4038], 'Mortarini': [3816, 4040], 'Noonan': [3818, 4042], 'D.M.': [3819, 4043], 'Natali': [3820, 4044], 'Albini': [3822, 4046], 'Int.': [3824, 4048, 4156], 'Cancer.': [3826, 4050], '87:': [3828, 4052], '336-342Crossref': [3829, 4053], '(245)': [3832, 4056], 'Mesangial': [3835, 4076], 'exhibited': [3837, 4353], 'phenotype': [3840], '3C).': [3842], 'α1β1,': [3849, 3923, 4086], 'α2β1,': [3850, 3924, 4087], 'α6β1,': [3853, 3927, 4090], 'spreading': [3858, 3884, 4382], 'Small': [3866], 'molecule': [3867], 'inhibitory.': [3877], '3C)': [3886], 'overall': [3889], 'Consistent': [3897], 'partial': [3903], 'antagonizing': [3906], 'individual': [3907, 4351], 'effects': [3910], 'observed': [3912, 4529], 'antagonist.': [3921], 'αvβ1': [3929, 4093], 'apparently': [3942], 'contradictory,': [3943], 'disparate': [3945], 'rationalized': [3954], 'considering': [3956], 'relative': [3958], 'line.': [3969], 'repertoire,': [3990], '30Barazi': [4059], 'Zhou': [4061], 'Templeton': [4063], 'N.S.': [4064], '62:': [4072], '1541-1548PubMed': [4073], 'broader': [4080], 'range': [4081], 'α5β1,': [4089], 'α8β1,': [4091], '31Yi': [4126], 'X.Y.': [4127], 'Wayner': [4128], 'E.A.': [4129], 'Kim': [4130], 'Fish': [4132], 'A.J.': [4133], '5:': [4138], '237-248Crossref': [4139], '(25)': [4142], '32Hartner': [4145], 'Schocklmann': [4147], 'Prols': [4149], 'Muller': [4151], 'U.': [4152], 'Sterzel': [4153], 'Kidney': [4155], '56:': [4158], '1468-1480Abstract': [4159], 'α-specific': [4172], 'affected': [4174], 'This': [4182, 4525], 'suggests': [4183], 'pan-specific': [4188, 4607], 'Both': [4193], 'TSR2': [4194, 4388, 4485, 4506, 4577], 'TSR3': [4196, 4324, 4487, 4508, 4579], 'Integrins—The': [4201], 'above': [4202], 'either': [4207], 'single': [4210], 'promiscuous': [4211], 'integrin.': [4229], 'localize': [4232], 'site(s)': [4236], 'forms': [4243], 'adhesive': [4253], '4).': [4256], '∼2-fold': [4274], '4A).': [4278], 'construct': [4289], '(TSR123)': [4294], 'activation,': [4302], 'dose-dependent': [4308], 'TSR2,': [4311], 'TSR123,': [4312], 'unstimulated': [4321], 'artifact': [4328], 'its': [4341], 'relatively': [4342], 'inefficient': [4343], 'adsorption': [4344], 'polystyrene.': [4346], '4B).': [4364], '0.4': [4368], 'Mn2+-stimulated': [4370], 'abolished': [4379, 4396], 'TSR3.': [4390], 'Spreading': [4391], 'EDTA,': [4398, 4423], 'Attachment': [4407], 'even': [4414], 'stronger': [4415], 'full-length': [4432], 'cation-independent.': [4438], 'whether': [4441, 4633], 'apparent': [4443], 'pan': [4444], 'intrinsic': [4449], 'recognizing': [4458], 'different': [4459, 4587], 'compared': [4463], 'promote': [4467], '4,': [4477], 'C–D).': [4478], 'strongly': [4490], '4C).': [4500, 4524], '(33Chandrasekaran': [4545], 'Rodrigues': [4549], 'R.G.': [4550], 'Kaiser': [4551], '11408-11416Abstract': [4560], '(111)': [4568], 'ability': [4574], 'cell-specific': [4592], 'manner,': [4593], 'conclude': [4595], 'Several': [4612], 'functional': [4613, 4638], 'peptide': [4614], 'sequences': [4615, 4639], 'identified': [4618], 'receptors.': [4630], 'any': [4634], 'int': [4642]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031088831', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-21T12:15:55.534500', 'created_date': '2016-06-24'}
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