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'https://openalex.org/W2036868678', 'https://openalex.org/W2055203083', 'https://openalex.org/W2083838472', 'https://openalex.org/W2112580075', 'https://openalex.org/W2136248567', 'https://openalex.org/W2142587628', 'https://openalex.org/W2163052225'], 'related_works': ['https://openalex.org/W4237618140', 'https://openalex.org/W4221064061', 'https://openalex.org/W2795629650', 'https://openalex.org/W2339552918', 'https://openalex.org/W2091401210', 'https://openalex.org/W2031035248', 'https://openalex.org/W2005266194', 'https://openalex.org/W1982637620', 'https://openalex.org/W1908365115', 'https://openalex.org/W1554981735'], 'abstract_inverted_index': {'BackgroundIL-5': [0], 'is': [1, 199], 'a': [2, 31, 54, 127, 188, 214], 'cytokine': [3], 'critically': [4], 'involved': [5, 24], 'in': [6, 25, 62, 76, 133, 149, 187, 191, 202, 211], 'regulating': [7], 'several': [8, 65], 'aspects': [9], 'of': [10, 28, 33, 53, 67, 74, 106, 122, 164, 173, 216], 'eosinophils': [11], 'including': [12], 'their': [13], 'production,': [14], 'activation,': [15], 'and': [16, 51, 120, 136, 171, 206], 'tissue': [17, 44, 102, 181, 192], 'recruitment.': [18], 'As': [19, 219], 'such,': [20, 220], 'IL-5': [21, 60], 'may': [22, 222], 'be': [23], 'the': [26, 49, 161], 'pathogenesis': [27], 'hypereosinophilic': [29, 95, 228], 'syndromes,': [30], 'group': [32], 'poorly': [34], 'treated': [35], 'diverse': [36], 'disorders': [37], 'characterized': [38], 'by': [39, 98], 'sustained': [40, 154], 'peripheral': [41, 99, 113, 138], 'blood': [42, 100, 114, 139], 'and/or': [43, 101, 115], 'eosinophilia.ObjectiveWe': [45], 'aimed': [46], 'to': [47, 91], 'assess': [48], 'safety': [50], 'efficacy': [52], 'humanized': [55], 'blocking': [56], 'monoclonal': [57], 'antibody': [58], 'against': [59], '(mepolizumab)': [61], 'patients': [63, 93, 135, 212], 'with': [64, 94, 179, 213], 'forms': [66], 'hyper-eosinophilic': [68, 217], 'syndromes.MethodsWe': [69], 'performed': [70], 'an': [71], 'open-label': [72], 'trial': [73], 'anti–IL-5': [75, 168, 185, 198, 221], 'which': [77], '3': [78], 'intravenous': [79], 'doses': [80], '(10': [81], 'mg/kg,': [82], 'maximum': [83], '750': [84], 'mg)': [85], 'were': [86, 124], 'administered': [87], 'at': [88, 156], '4-week': [89], 'intervals': [90], '4': [92], 'syndromes': [96], '(defined': [97], 'eosinophilia).': [103], 'The': [104, 147], 'effects': [105, 210], 'treatment': [107], 'on': [108], 'safety,': [109], 'eosinophil': [110, 140, 151, 193, 204], 'levels': [111], '(in': [112], 'diseased': [116], 'tissue),': [117], 'pulmonary': [118], 'function,': [119], 'quality': [121, 172], 'life': [123, 174], 'measured': [125], 'over': [126], '28-week': [128], 'period.ResultsAnti–IL-5': [129], 'was': [130, 153], 'well': [131], 'tolerated': [132], 'all': [134], 'lowered': [137], 'counts': [141, 152], 'despite': [142], 'ongoing': [143], 'systemic': [144], 'glucocorticoid': [145], 'therapy.': [146], 'decline': [148], 'circulating': [150], 'for': [155, 227], 'least': [157], '12': [158], 'weeks': [159], 'after': [160], 'last': [162], 'dose': [163], 'anti–IL-5.': [165], 'In': [166, 176], 'addition,': [167], 'improved': [169], 'clinical': [170], 'measurements.': [175], 'one': [177], 'patient': [178], 'striking': [180], 'eosinophilia': [182], '(eosinophilic': [183], 'esophagitis),': [184], 'resulted': [186], '10-fold': [189], 'reduction': [190], 'levels.ConclusionsThese': [194], 'results': [195], 'suggest': [196], 'that': [197], 'safe,': [200], 'effective': [201], 'lowering': [203], 'levels,': [205], 'has': [207], 'potential': [208, 226], 'glucocorticoid-sparing': [209], 'variety': [215], 'syndromes.': [218, 229], 'have': [223], 'significant': [224], 'therapeutic': [225]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031035248', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 20}], 'updated_date': '2024-09-01T03:03:55.885715', 'created_date': '2016-06-24'}