Title: Effect of monoamine oxidase inhibitors on the disposition of intracisternally administered metaraminol-3H
Abstract: The effect of several monoamine oxidase inhibitors on the disappearance of intracisternally injected metaraminol-3H, a synthetic monoamine which is resistant to the action of monoamine oxidase, was studied in the rat. Pretreatment with phenelzine, pheniprazine or nialamide markedly accelerated the disappearance of metaraminol-3H from brain, while pargyline pretreatment substantially retarded its escape. In contrast, both pheniprazine and pargyline were found to significantly hasten the disappearance of the labeled amine from heart. Phenelzine or pheniprazine failed to alter the uptake of intracisternally injected metaraminol-3H into brain, and neither pargyline nor pheniprazine affected the disappearance of intracisternally administered urea-14C or a-aminoisobutyric acid-14C. These findings are consistent with the view that pargyline interferes with monoamine transport from brain, while pheniprazine, nialamide, and phenelzine act to displace metaraminol by promoting the accumulation of endogenous amines.
Publication Year: 1970
Publication Date: 1970-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 5
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