Cytotoxic Clerodane Diterpenoids from <i>Casearia obliqua</i>

Name: Work Video:
Duration: 3 min 30 s
Gerardo Magela Vieira Júnior; Tiago de Oliveira Gonçalves; Luís Octávio Regasini; Paulo Michel Pinheiro Ferreira; Cláudia Pessoa; Letícia V. Costa‐Lotufo; Roseli Buzanelli Torres; Nivaldo Boralle; Vanderlan da Silva Bolzani; Alberto José Cavalheiro
{'id': 'https://openalex.org/W2030513592', 'doi': 'https://doi.org/10.1021/np9004079', 'title': 'Cytotoxic Clerodane Diterpenoids from <i>Casearia obliqua</i>', 'display_name': 'Cytotoxic Clerodane Diterpenoids from <i>Casearia obliqua</i>', 'publication_year': 2009, 'publication_date': '2009-09-29', 'ids': {'openalex': 'https://openalex.org/W2030513592', 'doi': 'https://doi.org/10.1021/np9004079', 'mag': '2030513592', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19788290'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/np9004079', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S166799026', 'display_name': 'Journal of Natural Products', 'issn_l': '0163-3864', 'issn': ['0163-3864', '1520-6025'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081733589', 'display_name': 'Gerardo Magela Vieira Júnior', 'orcid': 'https://orcid.org/0000-0001-8113-8957'}, 'institutions': [{'id': 'https://openalex.org/I4210125957', 'display_name': 'Agronomical Institute of Campinas', 'ror': 'https://ror.org/02ms7ap07', 'country_code': 'BR', 'type': 'government', 'lineage': ['https://openalex.org/I4210096253', 'https://openalex.org/I4210125957']}, {'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}, {'id': 'https://openalex.org/I243754102', 'display_name': 'Universidade Federal do Ceará', 'ror': 'https://ror.org/03srtnf24', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I243754102']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Gerardo Magela Vieira Júnior', 'raw_affiliation_strings': ['Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902', 'institution_ids': ['https://openalex.org/I4210125957', 'https://openalex.org/I879563668', 'https://openalex.org/I243754102']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029021717', 'display_name': 'Tiago de Oliveira Gonçalves', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I243754102', 'display_name': 'Universidade Federal do Ceará', 'ror': 'https://ror.org/03srtnf24', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I243754102']}, {'id': 'https://openalex.org/I4210125957', 'display_name': 'Agronomical Institute of Campinas', 'ror': 'https://ror.org/02ms7ap07', 'country_code': 'BR', 'type': 'government', 'lineage': ['https://openalex.org/I4210096253', 'https://openalex.org/I4210125957']}, {'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Tiago de Oliveira Gonçalves', 'raw_affiliation_strings': ['Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902', 'institution_ids': ['https://openalex.org/I243754102', 'https://openalex.org/I4210125957', 'https://openalex.org/I879563668']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048423669', 'display_name': 'Luís Octávio Regasini', 'orcid': 'https://orcid.org/0000-0002-3705-0971'}, 'institutions': [{'id': 'https://openalex.org/I4210125957', 'display_name': 'Agronomical Institute of Campinas', 'ror': 'https://ror.org/02ms7ap07', 'country_code': 'BR', 'type': 'government', 'lineage': ['https://openalex.org/I4210096253', 'https://openalex.org/I4210125957']}, {'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}, {'id': 'https://openalex.org/I243754102', 'display_name': 'Universidade Federal do Ceará', 'ror': 'https://ror.org/03srtnf24', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I243754102']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Luis O. Regasini', 'raw_affiliation_strings': ['Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902', 'institution_ids': ['https://openalex.org/I4210125957', 'https://openalex.org/I879563668', 'https://openalex.org/I243754102']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100619388', 'display_name': 'Paulo Michel Pinheiro Ferreira', 'orcid': 'https://orcid.org/0000-0001-6862-6497'}, 'institutions': [{'id': 'https://openalex.org/I243754102', 'display_name': 'Universidade Federal do Ceará', 'ror': 'https://ror.org/03srtnf24', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I243754102']}, {'id': 'https://openalex.org/I4210125957', 'display_name': 'Agronomical Institute of Campinas', 'ror': 'https://ror.org/02ms7ap07', 'country_code': 'BR', 'type': 'government', 'lineage': ['https://openalex.org/I4210096253', 'https://openalex.org/I4210125957']}, {'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Paulo M. Pinheiro Ferreira', 'raw_affiliation_strings': ['Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902', 'institution_ids': ['https://openalex.org/I243754102', 'https://openalex.org/I4210125957', 'https://openalex.org/I879563668']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087731343', 'display_name': 'Cláudia Pessoa', 'orcid': 'https://orcid.org/0000-0002-4344-4336'}, 'institutions': [{'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}, {'id': 'https://openalex.org/I243754102', 'display_name': 'Universidade Federal do Ceará', 'ror': 'https://ror.org/03srtnf24', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I243754102']}, {'id': 'https://openalex.org/I4210125957', 'display_name': 'Agronomical Institute of Campinas', 'ror': 'https://ror.org/02ms7ap07', 'country_code': 'BR', 'type': 'government', 'lineage': ['https://openalex.org/I4210096253', 'https://openalex.org/I4210125957']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Cláudia do Ó Pessoa', 'raw_affiliation_strings': ['Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902', 'institution_ids': ['https://openalex.org/I879563668', 'https://openalex.org/I243754102', 'https://openalex.org/I4210125957']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088398854', 'display_name': 'Letícia V. Costa‐Lotufo', 'orcid': 'https://orcid.org/0000-0003-1861-5153'}, 'institutions': [{'id': 'https://openalex.org/I4210125957', 'display_name': 'Agronomical Institute of Campinas', 'ror': 'https://ror.org/02ms7ap07', 'country_code': 'BR', 'type': 'government', 'lineage': ['https://openalex.org/I4210096253', 'https://openalex.org/I4210125957']}, {'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}, {'id': 'https://openalex.org/I243754102', 'display_name': 'Universidade Federal do Ceará', 'ror': 'https://ror.org/03srtnf24', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I243754102']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Letícia V. Costa Lotufo', 'raw_affiliation_strings': ['Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902', 'institution_ids': ['https://openalex.org/I4210125957', 'https://openalex.org/I879563668', 'https://openalex.org/I243754102']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018360579', 'display_name': 'Roseli Buzanelli Torres', 'orcid': 'https://orcid.org/0000-0001-5299-9168'}, 'institutions': [{'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}, {'id': 'https://openalex.org/I243754102', 'display_name': 'Universidade Federal do Ceará', 'ror': 'https://ror.org/03srtnf24', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I243754102']}, {'id': 'https://openalex.org/I4210125957', 'display_name': 'Agronomical Institute of Campinas', 'ror': 'https://ror.org/02ms7ap07', 'country_code': 'BR', 'type': 'government', 'lineage': ['https://openalex.org/I4210096253', 'https://openalex.org/I4210125957']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Roseli Buzanelli Torres', 'raw_affiliation_strings': ['Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902', 'institution_ids': ['https://openalex.org/I879563668', 'https://openalex.org/I243754102', 'https://openalex.org/I4210125957']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007095794', 'display_name': 'Nivaldo Boralle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210125957', 'display_name': 'Agronomical Institute of Campinas', 'ror': 'https://ror.org/02ms7ap07', 'country_code': 'BR', 'type': 'government', 'lineage': ['https://openalex.org/I4210096253', 'https://openalex.org/I4210125957']}, {'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}, {'id': 'https://openalex.org/I243754102', 'display_name': 'Universidade Federal do Ceará', 'ror': 'https://ror.org/03srtnf24', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I243754102']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Nivaldo Boralle', 'raw_affiliation_strings': ['Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902', 'institution_ids': ['https://openalex.org/I4210125957', 'https://openalex.org/I879563668', 'https://openalex.org/I243754102']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090119048', 'display_name': 'Vanderlan da Silva Bolzani', 'orcid': 'https://orcid.org/0000-0003-0615-8776'}, 'institutions': [{'id': 'https://openalex.org/I4210125957', 'display_name': 'Agronomical Institute of Campinas', 'ror': 'https://ror.org/02ms7ap07', 'country_code': 'BR', 'type': 'government', 'lineage': ['https://openalex.org/I4210096253', 'https://openalex.org/I4210125957']}, {'id': 'https://openalex.org/I243754102', 'display_name': 'Universidade Federal do Ceará', 'ror': 'https://ror.org/03srtnf24', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I243754102']}, {'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Vanderlan da Silva Bolzani', 'raw_affiliation_strings': ['Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902', 'institution_ids': ['https://openalex.org/I4210125957', 'https://openalex.org/I243754102', 'https://openalex.org/I879563668']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054832959', 'display_name': 'Alberto José Cavalheiro', 'orcid': 'https://orcid.org/0000-0001-8214-9957'}, 'institutions': [{'id': 'https://openalex.org/I4210125957', 'display_name': 'Agronomical Institute of Campinas', 'ror': 'https://ror.org/02ms7ap07', 'country_code': 'BR', 'type': 'government', 'lineage': ['https://openalex.org/I4210096253', 'https://openalex.org/I4210125957']}, {'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}, {'id': 'https://openalex.org/I243754102', 'display_name': 'Universidade Federal do Ceará', 'ror': 'https://ror.org/03srtnf24', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I243754102']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Alberto José Cavalheiro', 'raw_affiliation_strings': ['Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97, Laboratório de Oncologia Experimental (LOE), Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil, CP 12.200, CEP 60430-270, and Núcleo do Jardim Botânico, Instituto Agronômico de Campinas, Campinas, SP, Brazil, CP 28, CEP 13020-902', 'institution_ids': ['https://openalex.org/I4210125957', 'https://openalex.org/I879563668', 'https://openalex.org/I243754102']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.813, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.78578, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '72', 'issue': '10', 'first_page': '1847', 'last_page': '1850'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T14297', 'display_name': 'Plant-Derived Bioactive Compounds', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T14297', 'display_name': 'Plant-Derived Bioactive Compounds', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C206103511', 'wikidata': 'https://www.wikidata.org/wiki/Q426694', 'display_name': 'Terpenoid', 'level': 2, 'score': 0.5969945}, {'id': 'https://openalex.org/C2776710815', 'wikidata': 'https://www.wikidata.org/wiki/Q59447', 'display_name': 'Diterpene', 'level': 2, 'score': 0.5804231}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.49495167}, {'id': 'https://openalex.org/C160492267', 'wikidata': 'https://www.wikidata.org/wiki/Q319616', 'display_name': 'Pharmacognosy', 'level': 4, 'score': 0.41555533}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40641928}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3590279}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.35870662}, {'id': 'https://openalex.org/C116073593', 'wikidata': 'https://www.wikidata.org/wiki/Q864491', 'display_name': 'Biological activity', 'level': 3, 'score': 0.12951553}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08051023}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.056144804}], 'mesh': [{'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D045785', 'descriptor_name': 'Diterpenes, Clerodane', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D045785', 'descriptor_name': 'Diterpenes, Clerodane', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001938', 'descriptor_name': 'Brazil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045785', 'descriptor_name': 'Diterpenes, Clerodane', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D045785', 'descriptor_name': 'Diterpenes, Clerodane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004354', 'descriptor_name': 'Drug Screening Assays, Antitumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019906', 'descriptor_name': 'Nuclear Magnetic Resonance, Biomolecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018515', 'descriptor_name': 'Plant Leaves', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018515', 'descriptor_name': 'Plant Leaves', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/np9004079', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S166799026', 'display_name': 'Journal of Natural Products', 'issn_l': '0163-3864', 'issn': ['0163-3864', '1520-6025'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19788290', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15', 'score': 0.43}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1547933093', 'https://openalex.org/W1575942862', 'https://openalex.org/W1740391705', 'https://openalex.org/W1966176412', 'https://openalex.org/W1973115383', 'https://openalex.org/W1981292890', 'https://openalex.org/W1987630499', 'https://openalex.org/W2006081560', 'https://openalex.org/W2014235395', 'https://openalex.org/W2026584107', 'https://openalex.org/W2033568593', 'https://openalex.org/W2052738776', 'https://openalex.org/W2064982059', 'https://openalex.org/W2068328659', 'https://openalex.org/W2072407552', 'https://openalex.org/W2077488320', 'https://openalex.org/W2104545570', 'https://openalex.org/W2114918609', 'https://openalex.org/W2164146480', 'https://openalex.org/W2328605987', 'https://openalex.org/W2328722981', 'https://openalex.org/W2951631141'], 'related_works': ['https://openalex.org/W3208291434', 'https://openalex.org/W3110885250', 'https://openalex.org/W2809711747', 'https://openalex.org/W2742438557', 'https://openalex.org/W2401785410', 'https://openalex.org/W2053578768', 'https://openalex.org/W2053462896', 'https://openalex.org/W2040430308', 'https://openalex.org/W2028242265', 'https://openalex.org/W2014074068'], 'abstract_inverted_index': {'A': [0, 17], 'crude': [1], 'bioactive': [2, 27], 'EtOH': [3], 'extract': [4, 29], 'of': [5, 8, 30, 40, 59, 71, 100, 102, 112], 'the': [6, 31, 38, 41, 60, 69, 80, 85, 103], 'twigs': [7], 'Casearia': [9], 'obliqua': [10], 'afforded': [11], 'two': [12], 'new': [13, 61, 81], 'clerodane': [14, 43], 'diterpenes,': [15], 'caseobliquins': [16], '(1)': [18], 'and': [19, 46, 49, 54, 64, 74, 79, 84], 'B': [20], '(2).': [21], 'Additionally,': [22], 'bioactivity-directed': [23], 'fractionation': [24], 'on': [25, 68], 'a': [26, 52, 109], 'hexane': [28], 'leaves': [32], 'from': [33], 'this': [34], 'species': [35], 'led': [36], 'to': [37], 'isolation': [39], 'known': [42, 86], 'diterpenes': [44], 'rel-6β-hydroxyzuelanin-2β-benzoate': [45], 'rel-2α-hydroxyzuelanin-6β-benzoate': [47], '(3': [48], '4)': [50], 'as': [51], 'mixture': [53], '2β-hydroxyzuelanin-6β-cinnamate': [55], '(5).': [56], 'The': [57, 98], 'structures': [58], 'clerodanes': [62], '1': [63, 83], '2': [65], 'were': [66], 'established': [67], 'basis': [70], 'their': [72, 90], '1D': [73], '2D': [75], 'NMR': [76], 'spectroscopic': [77], 'data,': [78], 'compound': [82], 'substance': [87], '5': [88], 'had': [89], 'absolute': [91], 'configurations': [92], 'determined': [93], 'by': [94], 'circular': [95], 'dichroism': [96], 'spectroscopy.': [97], 'cytotoxicity': [99], 'several': [101], 'compounds': [104], 'isolated': [105], 'was': [106], 'evaluated': [107], 'against': [108], 'small': [110], 'panel': [111], 'human': [113], 'tumor': [114], 'cell': [115], 'lines.': [116]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2030513592', 'counts_by_year': [{'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T12:25:05.784460', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
