Publication Information

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203, 214, 228, 253, 330, 354, 397, 415, 488, 502, 529, 620, 794, 936, 1208, 1294, 1301, 1321, 1354, 1502, 1513, 1549, 1552, 1569, 1921, 2008, 2291, 2394, 2406, 2607, 2690, 2743, 3010, 3193, 3296, 3565, 3635, 3681, 3790, 3830, 3966, 3996, 4240, 4411, 4530, 4553, 4633, 5025, 5246, 5277], '(nucleophosmin)': [3, 215], 'are': [4, 129, 161, 216, 341, 373, 1503, 1518, 2726, 2819, 2829, 3131, 3154, 3350, 3377, 3801, 3934, 4215, 4247, 4783], 'the': [5, 20, 26, 32, 50, 59, 62, 86, 92, 95, 105, 114, 126, 138, 179, 192, 199, 217, 232, 238, 244, 262, 271, 274, 298, 304, 307, 317, 326, 338, 350, 391, 404, 411, 490, 518, 527, 536, 624, 627, 967, 971, 1217, 1290, 1491, 1497, 1510, 1543, 1574, 1588, 1700, 1707, 1718, 1737, 1892, 1907, 1944, 2006, 2053, 2084, 2114, 2117, 2120, 2132, 2135, 2139, 2157, 2162, 2171, 2205, 2275, 2303, 2325, 2335, 2399, 2470, 2541, 2546, 2598, 2606, 2612, 2619, 2646, 2657, 2667, 2711, 2747, 2813, 2827, 2832, 2846, 2931, 2948, 3039, 3051, 3069, 3102, 3120, 3143, 3170, 3173, 3214, 3240, 3247, 3288, 3292, 3295, 3301, 3304, 3308, 3312, 3315, 3321, 3328, 3333, 3347, 3352, 3365, 3369, 3372, 3391, 3432, 3493, 3500, 3504, 3511, 3518, 3521, 3567, 3645, 3672, 3693, 3696, 3699, 3787, 3792, 3804, 3829, 3880, 3884, 3900, 3913, 3944, 3947, 3954, 3965, 3969, 3982, 4010, 4023, 4105, 4109, 4132, 4146, 4150, 4156, 4163, 4166, 4173, 4182, 4194, 4208, 4219, 4231, 4236, 4272, 4298, 4303, 4334, 4337, 4363, 4366, 4371, 4405, 4409, 4416, 4430, 4435, 4446, 4464, 4481, 4503, 4511, 4551, 4557, 4562, 4577, 4580, 4602, 4609, 4629, 4666, 4677, 4681, 4702, 4755, 5028, 5225, 5241, 5253, 5261, 5264, 5273], 'most': [6, 21, 218, 233, 491, 2970, 3241, 3316, 4558], 'common': [7, 219, 492, 3317, 3335], 'genetic': [8, 220, 493], 'lesions': [9, 221, 494], 'found': [10, 24, 222, 236, 3513, 4119, 4193, 4549], 'in': [11, 25, 43, 113, 148, 223, 237, 255, 325, 360, 431, 498, 526, 939, 1210, 1303, 1606, 1629, 1715, 1974, 1995, 2065, 2156, 2302, 2411, 2427, 2455, 2484, 2513, 2527, 2545, 2564, 2570, 2695, 2821, 2969, 2976, 2983, 3002, 3119, 3311, 3332, 3415, 3514, 3640, 3680, 3698, 3899, 4224, 4230, 4368, 4422, 4561, 4601, 4706, 4718, 4771, 4787, 4791, 4990, 5022, 5232, 5247, 5287], 'acute': [12, 224, 437, 1148, 1176], 'myeloid': [13, 225, 438, 445, 468, 1149, 1177], 'leukemia': [14, 226, 439, 1150, 1178, 5288], '(AML).': [15, 227], 'is': [17, 45, 58, 135, 144, 229, 257, 270, 347, 356, 429, 510, 530, 795, 937, 964, 1080, 1212, 1341, 1528, 1714, 2664, 2677, 3022, 3059, 3071, 3105, 3139, 3145, 3325, 3339, 3487, 3547, 3552, 3623, 4005, 4019, 4284, 4499, 4541, 4548, 4554, 4568, 4582, 4599, 4606, 4616, 4675, 4704, 4711, 4726, 4766, 5033], 'one': [18, 69, 230, 281, 4555], 'of': [19, 40, 52, 61, 64, 88, 94, 107, 117, 141, 181, 194, 202, 231, 252, 264, 273, 276, 300, 306, 319, 329, 353, 393, 406, 414, 433, 521, 596, 942, 1084, 1207, 1219, 1285, 1293, 1299, 1308, 1320, 1343, 1501, 1522, 1533, 1576, 1706, 1717, 1736, 1879, 1888, 1901, 1920, 1958, 1999, 2028, 2055, 2097, 2108, 2126, 2150, 2255, 2290, 2356, 2376, 2447, 2605, 2611, 2614, 2689, 2710, 2728, 2737, 2742, 2758, 2799, 2840, 2852, 2855, 2973, 2980, 2986, 3009, 3024, 3054, 3061, 3068, 3096, 3172, 3287, 3294, 3303, 3307, 3346, 3368, 3406, 3423, 3426, 3435, 3445, 3454, 3464, 3489, 3503, 3520, 3525, 3648, 3674, 3689, 3695, 3789, 3803, 3807, 3826, 3871, 3883, 3887, 3946, 3984, 4022, 4112, 4135, 4165, 4184, 4205, 4210, 4234, 4239, 4336, 4347, 4355, 4365, 4375, 4408, 4485, 4502, 4506, 4520, 4556, 4632, 4670, 4701, 4732, 5214, 5236, 5245, 5255, 5263, 5266, 5276], 'abundant': [22, 234, 4559, 4600], 'proteins': [23, 235, 720, 1302, 1618, 1734, 3098, 3124, 3212, 4560, 4789], 'nucleolus': [27, 239, 4011, 4147, 4581], 'and': [28, 91, 122, 143, 186, 209, 240, 303, 334, 355, 398, 421, 626, 719, 823, 910, 1079, 1347, 1516, 1551, 1559, 1562, 1611, 1627, 1636, 1676, 1682, 1709, 1721, 1726, 1740, 1758, 1807, 1837, 1848, 1864, 1881, 1903, 1909, 1972, 1989, 2025, 2101, 2119, 2138, 2154, 2165, 2266, 2284, 2296, 2314, 2330, 2380, 2482, 2572, 2693, 2701, 2718, 2746, 2760, 2809, 2843, 2917, 2925, 3031, 3056, 3081, 3092, 3111, 3113, 3128, 3137, 3160, 3166, 3187, 3357, 3360, 3362, 3383, 3410, 3437, 3440, 3468, 3533, 3569, 3676, 3692, 3799, 3813, 3835, 3854, 3924, 3929, 3949, 3958, 4007, 4095, 4118, 4128, 4192, 4207, 4245, 4250, 4271, 4277, 4305, 4327, 4330, 4341, 4353, 4415, 4432, 4434, 4488, 4509, 4515, 4564, 4604, 4654, 4714, 4721, 4978, 5032, 5260], 'has': [29, 241, 3196, 3535, 3575, 3682, 3778, 4030, 4531, 4623], 'links': [30, 242], 'to': [31, 49, 177, 190, 204, 243, 261, 389, 402, 416, 496, 517, 825, 966, 1216, 1591, 1732, 1741, 1873, 2093, 2324, 2333, 2350, 2362, 2500, 2679, 2686, 2740, 3027, 3048, 3064, 3134, 3178, 3201, 3364, 3388, 3473, 3497, 3517, 3563, 3566, 3678, 3685, 3687, 3786, 3791, 3823, 3838, 3895, 3907, 3920, 3926, 4101, 4104, 4121, 4155, 4160, 4181, 4197, 4217, 4269, 4288, 4309, 4318, 4429, 4543, 4579, 4591, 4612, 4626, 4628, 4657, 4689, 4776, 4985, 5019, 5027, 5224], 'MDM2/p53': [33, 245], 'tumor': [34, 246, 972, 4756, 5030], 'suppressor': [35, 247, 973, 4757, 5031], 'pathway.': [36, 248], 'A': [37, 249, 1204, 1561, 1662, 2440, 3409, 3439, 3460, 3583, 3626, 4099, 4115, 4137, 4179], 'distinctive': [38, 250, 1205], 'feature': [39, 251, 1206], 'mutants': [42, 254, 1209, 1323, 1560, 3408, 3438, 4412], 'AML': [44, 149, 182, 256, 361, 394, 1211, 3515, 5249], 'their': [46, 258, 1213, 1743, 3819, 4256], 'aberrant': [47, 259, 1214, 1296, 4220, 5242], 'localization': [48, 260, 1215, 1298, 1356, 3651, 3691, 3876, 3989, 4018, 4222, 4279, 4407, 4474, 4492, 4694], 'cytoplasm': [51, 263, 628, 1218, 5226], 'leukemic': [53, 265, 1220, 1322], 'cells.': [54, 266, 4000], 'This': [55, 133, 170, 267, 345, 382, 2661, 3557, 3866, 4200, 4477], 'mutant': [56, 268, 1300, 1577, 3319, 3336, 3459, 3542, 3558, 3582, 4002, 4098, 4114, 4136, 4178, 4418, 4437, 4457], 'phenotype': [57, 269], 'result': [60, 272, 1705, 4479], 'substitution': [63, 275], 'several': [65, 277, 3236], 'C-terminal': [66, 200, 278, 412, 1570, 1663, 1691, 1922, 2009, 2608, 2853, 3007, 3194, 3297, 3522, 3628, 3831, 3885, 3901, 4024, 4186, 4232, 4237, 4456, 4566, 4630, 5268, 5274], 'residues,': [67, 74, 279, 286], 'including': [68, 280, 830], 'or': [70, 282, 508, 1811, 1883, 3204, 4358, 4360, 4594, 4790, 5216], 'two': [71, 283, 1696, 4682], 'conserved': [72, 127, 156, 284, 339, 368, 3146, 3153, 4249], 'tryptophan': [73, 285, 1344], 'with': [75, 150, 183, 287, 362, 395, 1573, 1949, 2161, 2170, 2204, 2258, 2346, 2413, 2435, 2480, 2493, 2505, 2519, 2535, 2551, 2616, 2793, 3029, 3083, 3108, 3183, 3341, 3418, 3833, 3960, 4188, 4295, 4370, 4665, 5279], 'a': [76, 288, 511, 533, 713, 940, 1081, 1538, 1582, 1592, 1630, 1644, 1668, 1704, 1751, 1899, 1916, 1996, 2020, 2026, 2196, 2307, 2315, 2354, 2363, 2444, 2452, 2592, 2707, 2729, 2788, 2794, 3003, 3012, 3180, 3207, 3413, 3424, 3443, 3449, 3455, 3470, 3490, 3576, 3808, 3824, 3858, 4020, 4027, 4189, 4203, 4211, 4290, 4345, 4444, 4500, 4592, 4715, 4730, 5229, 5256], 'leucine-rich': [77, 289, 1311], 'nuclear': [78, 290, 522, 1151, 1154, 1179, 1182, 1312, 1318, 2888, 2997, 3578, 4006, 4151, 4174, 4212, 4350, 5257], 'export': [79, 291, 447, 470, 1152, 1180, 1313, 1319, 3579, 4152, 4157, 4175, 4213, 5258], 'signal.': [80, 292], 'The': [81, 293, 424, 1855, 2191, 2320, 2566, 2603, 2682, 2734, 2824, 3006, 3066, 3192, 3401, 4001, 4455, 4619, 5234], 'exact': [82, 294], 'molecular': [83, 295, 828, 1493, 4507], 'mechanism': [84, 296], 'underlying': [85, 297, 1545], 'loss': [87, 299, 1342, 3425, 3688, 3825, 4204], 'nucleolar': [89, 139, 168, 301, 351, 380, 1355, 1531, 3690, 3875, 4017, 4169, 4278, 4406, 4473, 4491, 4572, 4693], 'retention,': [90, 302], 'role': [93, 305, 4164, 5231], 'tryptophans,': [96, 308], 'remains': [97, 309], 'unknown.': [98, 310, 1504], 'In': [99, 311, 1505, 3314, 3371, 3669, 4523], 'this': [100, 312, 1506, 2000, 3384, 3395, 3570, 3670, 3891, 3916, 4113, 4524, 4544, 4565, 4671, 4699, 5237, 5280], 'study': [101, 171, 313, 383, 4525, 5238], 'we': [102, 123, 154, 314, 335, 366, 1508, 3397, 3893, 3918, 4171, 4526, 4686], 'have': [103, 315, 1693, 3795, 4527, 4687, 4987, 5284], 'determined': [104, 316, 1748, 2169, 2751], 'structure': [106, 318, 1967, 2158, 2621, 2749, 2792, 2828, 2950, 3844, 3910, 3976, 4206, 5265], 'an': [108, 320, 1309, 1523, 1694, 2414, 2584, 2672, 3035, 3477, 3483, 3637, 4532], 'independently': [109, 321, 1524], 'folded': [110, 322, 1525, 2730, 3456, 3501, 3809, 4534], 'globular': [111, 323, 3523], 'domain': [112, 134, 201, 324, 346, 413, 1526, 1571, 1599, 1664, 1923, 2010, 2663, 2670, 2854, 3008, 3195, 3244, 3524, 3810, 3832, 3886, 3902, 3967, 4025, 4187, 4238, 4275, 4304, 4338, 4367, 4466, 4514, 4535, 4567, 4631, 4703, 5275], 'C': [115, 327, 1291, 2956, 3305, 4110, 4133, 4538], 'terminus': [116, 328, 1292, 1702, 3306, 4111, 4134], 'using': [119, 331, 1566, 1613, 1667, 1750, 1898, 1915, 2019, 2195, 2306, 2464, 2574, 2583, 2597, 2752, 3213], 'NMR': [120, 332, 1828, 1945, 2014, 2061, 2717, 2735, 2757, 3399, 3404], 'spectroscopy,': [121, 333], 'report': [124, 336], 'that': [125, 160, 197, 337, 372, 409, 515, 1352, 1495, 1512, 1527, 1887, 2676, 2725, 3142, 3474, 3510, 3797, 3818, 3869, 3903, 3941, 4016, 4092, 4202, 4529, 4588, 4598, 4608, 4662, 4685, 4698, 4769, 4980, 5039, 5212, 5221, 5240, 5271], 'tryptophans': [128, 340, 1514], 'critical': [130, 342, 1519], 'for': [131, 137, 167, 175, 343, 349, 379, 387, 535, 715, 797, 1530, 1541, 1763, 1814, 1862, 1867, 1877, 1886, 1966, 2282, 2337, 2487, 2502, 2529, 2548, 2648, 2802, 2812, 2826, 2845, 2876, 2891, 2897, 3209, 3632, 3644, 4490, 4570, 4692, 4752, 4781], 'structure.': [132, 344, 3313, 3428, 3540, 3827], 'necessary': [136, 348, 4216, 4569], 'targeting': [140, 352, 1532], 'disrupted': [145, 357, 5021], 'by': [146, 358, 1556, 1564, 1621, 1639, 1684, 2653, 2671, 2699, 3074, 3327, 3379, 3847, 3878, 3990, 4033, 4126, 4344, 4729, 4759, 4785, 5036], 'mutations': [147, 359, 489, 3299, 3512, 3898, 3971, 3986, 4786, 4979], 'cytoplasmic': [151, 184, 363, 396, 1297, 4221, 5243], 'NPM1.': [152, 364, 1534, 3526, 3888], 'Furthermore,': [153, 365], 'identify': [155, 367], 'surface-exposed': [157, 369, 4251], 'lysine': [158, 370, 4241, 4450, 4683], 'residues': [159, 371, 1345, 1698, 2687, 2738, 3025, 3062, 3076, 3087, 3151, 3349, 3376, 3784, 3873, 3933, 3940, 4242, 4266, 4486, 4684], 'functionally': [162, 374, 4259, 4617], 'rather': [163, 375], 'than': [164, 376, 2263, 2271, 3581, 4463], 'structurally': [165, 377, 3190, 3210, 4314, 4403], 'important': [166, 378, 4260, 4315, 4478, 4691], 'localization.': [169, 381, 4573], 'provides': [172, 384], 'new': [173, 385, 3004], 'focus': [174, 386], 'efforts': [176, 388], 'understand': [178, 390], 'pathogenesis': [180, 392], 'may': [187, 399, 3188, 3559, 5227], 'be': [188, 400, 2680, 3189, 3386, 3816, 3905, 4122, 4198, 4690, 5020], 'used': [189, 401, 443, 466, 531, 1731, 1965, 3398], 'aid': [191, 403], 'design': [193, 405], 'small': [195, 407], 'molecules': [196, 408], 'target': [198, 410, 1083, 5272], 'act': [205, 417], 'as': [206, 418, 506, 532, 712, 1703, 2367, 2468, 3163, 3442, 3636, 3931, 4026, 4124, 4258, 4306, 4313, 4316, 4342, 4401, 4680], 'novel': [207, 419], 'anti-proliferative': [208, 420], 'anti-leukemia': [210, 422], 'therapeutics.': [211, 423], 'gene': [425], 'encoding': [426], 'nucleophosmin': [427], '(NPM1)': [428], 'mutated': [430, 3837, 4268], '50-60%': [432], 'normal': [434, 4143], 'karotype': [435], 'adult': [436], '(AML),': [440], '2The': [441, 464], 'abbreviations': [442, 465], 'are:AMLacute': [444, 467], 'leukemiaNESnuclear': [446, 469], 'signalNOESYnuclear': [448, 471], 'Overhauser': [449, 472, 1155, 1183, 2889, 2998, 4351], 'effect': [450, 473, 1156, 1184, 4471], 'spectroscopyeGFPenhanced': [451, 474], 'green': [452, 475, 1159, 1187, 2417, 3993], 'fluorescent': [453, 476, 1160, 1188, 2418, 3994], 'proteinMES4-morpholineethanesulfonic': [454, 477], 'acidPBSphosphate-buffered': [455, 478], 'salineTOCSYtotal': [456, 479], 'correlation': [457, 461, 480, 484, 1167, 1172, 1195, 1200], 'spectroscopyHSQCheteronuclear': [458, 481], 'single': [459, 482, 1170, 1198, 3243], 'quantum': [460, 483, 1171, 1199], 'spectroscopyMOPS4-morpholinepropanesulfonic': [462, 485], 'acid.': [463, 486, 1175, 1203], 'making': [487, 4149], 'identified': [495, 2706], 'date': [497, 3776], 'de': [499], 'novo': [500], 'AML.': [501, 1305, 1547, 4226, 5024, 5233], '(nucleophosmin,': [503], 'also': [504, 3935, 4453, 5017, 5034], 'known': [505], 'B23': [507], 'numatrin)': [509], 'ubiquitously': [512], 'expressed': [513, 1605, 2410], 'protein': [514, 1161, 1189, 1589, 1720, 2419, 2709, 2731, 3070, 3203, 3245, 3252, 3494, 3697, 4578, 4593, 4614, 4983], 'belongs': [516], 'nucleoplasmin': [519, 4504, 4547], 'family': [520, 4505], 'chaperones.': [523], 'Found': [524], 'predominantly': [525], 'nucleolus,': [528, 3568, 4563, 4603], 'marker': [534], 'granular': [537], 'component': [538], '(1Michalik': [539], 'J.': [540, 669, 695, 697, 700, 727, 782, 1111, 1132, 1273, 1332, 1406, 1421, 2040, 2180, 2223, 3658, 3706, 4042, 4642, 4798, 4802, 4832, 4856, 4858, 4916, 4932, 5172, 5193], 'Yeoman': [541], 'L.C.': [542], 'Busch': [543, 559], 'H.': [544, 560, 601, 896, 1478, 1931, 3763, 4800, 4834], 'Life': [545], 'Sci.': [546, 765, 1792, 3223, 3277], '1981;': [547], '28:': [548, 1936, 4808], '1371-1379Crossref': [549], 'PubMed': [550, 566, 589, 615, 644, 675, 706, 738, 755, 769, 791, 818, 847, 864, 879, 905, 931, 959, 989, 1007, 1024, 1045, 1074, 1115, 1143, 1278, 1411, 1466, 1485, 1776, 1796, 1938, 2186, 2245, 2640, 3230, 3281, 3616, 3664, 3751, 3770, 4087, 4394, 4649, 4744, 4810, 4848, 4879, 4943, 4973, 5010, 5057, 5075, 5092, 5113, 5142, 5176, 5204], 'Scopus': [551, 567, 590, 616, 645, 676, 707, 739, 756, 770, 819, 848, 865, 880, 906, 932, 960, 1008, 1025, 1046, 1075, 1116, 1144, 1279, 1412, 1467, 1486, 1777, 1797, 1939, 2046, 2187, 2246, 2641, 2781, 3231, 3282, 3617, 3665, 3752, 3771, 4088, 4395, 4650, 4745, 4811, 4849, 4880, 4944, 4974, 5011, 5076, 5093, 5114, 5143, 5177, 5205], '(36)': [552], 'Google': [553, 569, 592, 618, 647, 678, 709, 741, 758, 772, 792, 821, 850, 867, 882, 908, 934, 962, 990, 1010, 1027, 1048, 1077, 1118, 1146, 1281, 1337, 1414, 1469, 1488, 1779, 1799, 1941, 2048, 2189, 2248, 2643, 2770, 2783, 3233, 3284, 3619, 3667, 3754, 3773, 4090, 4397, 4652, 4747, 4813, 4851, 4882, 4946, 4976, 5013, 5058, 5078, 5095, 5116, 5145, 5179, 5207], 'Scholar,': [554, 570, 648, 679, 742, 759, 773, 851, 868, 883, 991, 1011, 1028, 1049, 1119, 1415, 1470, 1780, 2771, 3755, 4814, 4852, 4883, 4947, 5059, 5079, 5096, 5117, 5146, 5180], '2Spector': [555], 'D.L.': [556], 'Ochs': [557], 'R.L.': [558, 4961], 'Chromosoma': [561], '(Berl.).': [562], '1984;': [563], '90:': [564, 673], '139-148Crossref': [565], '(237)': [568], '3Andersen': [571], 'J.S.': [572, 2221], 'Lam': [573, 688], 'Y.W.': [574, 689], 'Leung': [575], 'A.K.': [576, 681], 'Ong': [577], 'S.E.': [578, 4901], 'Lyon': [579, 686], 'C.E.': [580], 'Lamond': [581, 698], 'A.I.': [582, 699], 'Mann': [583], 'M.': [584, 744, 746, 805, 918, 1015, 1107, 1231, 1254, 1325, 1364, 1387, 2225, 2632, 3653, 4387, 4822, 4963, 5083, 5168], 'Nature.': [585, 814, 927, 4875], '2005;': [586, 815, 928, 986, 1275, 1334, 1408, 5054], '433:': [587], '77-83Crossref': [588], '(927)': [591], 'Scholar)': [593, 710, 822, 909, 2049, 3234, 4091, 4653], '(the': [594], 'site': [595], 'pre-ribosomal': [597], 'subunit': [598], 'assembly': [599, 4793], '(4Tschochner': [600], 'Hurt': [602], 'E.': [603, 1030, 1229, 1242, 1362, 1375, 1443, 2696, 3728, 4064, 4870, 4891, 4899, 4905, 5098], 'Trends': [604, 3221], 'Cell': [605, 670, 701, 984, 1002, 1040, 3659, 5052, 5070, 5108], 'Biol.': [606, 702, 728, 750, 783, 901, 1003, 1020, 1041, 1133, 2240, 2777, 3660, 5006, 5071, 5088, 5109, 5194], '2003;': [607, 672, 1066, 4741, 5134], '13:': [608, 753, 2184], '255-263Abstract': [609], 'Full': [610, 612, 641, 733, 735, 788, 1069, 1071, 1138, 1140, 3227, 4938, 4940, 5137, 5139, 5199, 5201], 'Text': [611, 613, 642, 734, 736, 789, 1070, 1072, 1139, 1141, 3228, 4939, 4941, 5138, 5140, 5200, 5202], 'PDF': [614, 643, 737, 790, 1073, 1142, 3229, 4942, 5141, 5203], '(390)': [617], 'Scholar)).': [619], 'rapidly': [621], 'shuttles': [622], 'between': [623, 2116, 2134, 2294, 3354], 'nucleoplasm': [625], '(5Borer': [629], 'R.A.': [630], 'Lehner': [631], 'C.F.': [632], 'Eppenberger': [633], 'H.M.': [634], 'Nigg': [635], 'E.A.': [636], 'Cell.': [637, 751, 900, 1019, 1065, 5005, 5087, 5133], '1989;': [638, 1773, 1935], '56:': [639], '379-390Abstract': [640], '(904)': [646], '6Yun': [649], 'J.P.': [650], 'Chew': [651], 'E.C.': [652], 'Liew': [653], 'C.T.': [654], 'Chan': [655], 'J.Y.': [656], 'Jin': [657, 1054, 4995, 5122], 'M.L.': [658, 979, 5047], 'Ding': [659], 'M.X.': [660], 'Fai': [661], 'Y.H.': [662], 'Li': [663], 'H.K.': [664], 'Liang': [665], 'X.M.': [666], 'Wu': [667], 'Q.L.': [668], 'Biochem.': [671, 1481, 1772, 3222, 3766], '1140-1148Crossref': [674], '(61)': [677], '7Leung': [680], 'Gerlich': [682], 'D.': [683, 691, 775, 1013, 1034, 1059, 1240, 1373, 1439, 1925, 3724, 4060, 4735, 4804, 4836, 5081, 5102, 5127], 'Miller': [684], 'G.': [685, 1262, 1395, 1441, 1445, 1788, 1929, 2175, 3726, 3730, 4062, 4066, 4830, 4910, 4918, 5001], 'C.': [687, 948, 1227, 1360, 1459, 2034, 3220, 3602, 3744, 4080, 4912, 4924, 4965, 4998], 'Lleres': [690], 'Daigle': [692], 'N.': [693, 1258, 1271, 1330, 1391, 1404, 1419, 3585, 3704, 4040, 4816, 4838, 4842, 4864, 4953], 'Zomerdijk': [694], 'Ellenberg': [696], '2004;': [703, 1004, 1021, 5072, 5089], '166:': [704], '787-800Crossref': [705], '(127)': [708], 'serving': [711], 'chaperone': [714], 'both': [716, 3407, 3531, 5252], 'nucleic': [717, 4595], 'acids': [718], '(8Hingorani': [721], 'K.': [722, 748, 807, 811, 920, 924, 1051, 1087, 1854, 1933, 2756, 4922, 5119, 5148], 'Szebeni': [723, 778], 'A.': [724, 761, 777, 779, 1055, 1244, 1250, 1252, 1377, 1383, 1385, 1425, 1427, 1447, 2179, 2773, 3257, 3265, 3594, 3600, 3710, 3712, 3732, 4046, 4048, 4068, 4383, 4866, 4887, 4897, 4996, 5123], 'Olson': [725, 762, 780, 856, 871, 3656], 'M.O.': [726, 763, 781, 834, 836, 857, 872, 2036, 3657], 'Chem.': [729, 784, 1134, 4644, 5195], '2000;': [730, 3661], '275:': [731], '24451-24457Abstract': [732], '(211)': [740], '9Okuwaki': [743], 'Tsujimoto': [745], 'Nagata': [747], 'Mol.': [749, 899, 1001, 1018, 1064, 5004, 5069, 5086, 5132], '2002;': [752, 1042, 1482, 3767, 5110], '2016-2030Crossref': [754], '(147)': [757], '10Szebeni': [760], 'Protein': [764, 1745, 1791, 2378, 2833, 3276], '1999;': [766, 2183, 4845], '8:': [767], '905-912Crossref': [768], '(205)': [771, 3666], '11Wang': [774], 'Baumann': [776], '1994;': [785, 2778], '269:': [786], '30994-30998Abstract': [787], 'Scholar).': [793, 935, 1147, 1282, 1338, 1489, 1800, 1942, 1962, 2190, 2249, 2392, 2784, 3285, 3668, 3774, 4398, 4748, 5014, 5208], 'essential': [796, 1529], 'embryonic': [798], 'development': [799], '(12Grisendi': [800, 913], 'S.': [801, 914, 946, 1449, 2032, 3734, 4070, 4828], 'Bernardi': [802, 915], 'R.': [803, 855, 916, 1061, 1092, 1109, 1233, 1238, 1248, 1329, 1366, 1371, 1381, 1433, 1435, 3596, 3718, 3720, 4054, 4056, 4639, 4796, 5129, 5153, 5170], 'Rossi': [804, 917], 'Cheng': [806, 919], 'Khandker': [808, 921], 'L.': [809, 840, 922, 1094, 1235, 1368, 1431, 1786, 3218, 3716, 4052, 4381, 4908, 5155], 'Manova': [810, 923], 'Pandolfi': [812, 925, 951, 4736], 'P.P.': [813, 926, 952, 4737], '437:': [816, 929], '147-153Crossref': [817, 930], '(456)': [820, 933], 'appears': [824, 3177, 3496, 4287], 'modulate': [826], 'diverse': [827], 'functions,': [829], 'ribosome': [831, 4792], 'biogenesis': [832, 4710], '(13Olson': [833], 'Wallace': [835], 'Herrera': [837], 'A.H.': [838, 4928], 'Marshall-Carlson': [839], 'Hunt': [841], 'R.C.': [842], 'Biochemistry.': [843, 1934, 4390], '1986;': [844], '25:': [845], '484-491Crossref': [846], '(54)': [849], '14Herrera': [852], 'J.E.': [853, 4637], 'Savkur': [854], 'Nucleic': [858, 873, 2761], 'Acids': [859, 874], 'Res.': [860, 875, 3612], '1995;': [861, 1793, 2043, 3224], '23:': [862], '3974-3979Crossref': [863], '(133)': [866], '15Savkur': [869], 'R.S.': [870], '1998;': [876, 2242, 2637], '26:': [877, 903], '4508-4515Crossref': [878], '(189)': [881, 2782], '16Yu': [884], 'Y.': [885, 995, 1057, 1063, 1327, 1472, 1476, 3757, 3761, 5003, 5063, 5125, 5131], 'Maggi': [886, 996, 5064], 'Jr.,': [887, 997, 5065], 'L.B.': [888, 998, 4889, 5066], 'Brady': [889], 'S.N.': [890, 993, 5061], 'Apicelli': [891], 'A.J.': [892, 4967], 'Dai': [893], 'M.S.': [894, 4994], 'Lu': [895], 'Weber': [897, 999, 5067], 'J.D.': [898, 1000, 5068], '2006;': [902, 956, 1463, 3748, 4084, 4935], '3798-3809Crossref': [904], '(159)': [907], 'genomic': [911], 'stability': [912, 4276, 4364], 'overexpressed': [938, 2694], 'number': [941], 'solid': [943], 'tumors': [944], '(17Grisendi': [945], 'Mecucci': [947, 1226, 1359, 1458, 3601, 3743, 4079], 'Falini': [949, 1035, 3609, 4034, 5103], 'B.': [950, 1036, 1225, 1246, 1358, 1379, 1417, 1429, 3255, 3592, 3610, 3702, 3714, 4038, 4050, 4385, 4820, 4840, 4920, 4951, 5104], 'Nat.': [953, 1039, 4738, 4843, 4968, 5107], 'Rev.': [954, 4739], 'Cancer.': [955, 4740], '6:': [957], '493-505Crossref': [958], '(651)': [961], 'Scholar),': [963, 1078, 2644, 3620, 4977], 'linked': [965], 'p53/MDM2': [968], 'pathway': [969], 'via': [970, 4634], 'ARF': [974], '(18den': [975, 5043], 'Besten': [976, 5044], 'W.': [977, 1453, 1457, 3269, 3738, 3742, 4074, 4078, 5045], 'Kuo': [978, 5046], 'Williams': [980, 5048], 'R.T.': [981, 5049], 'Sherr': [982, 1016, 5050, 5084], 'C.J.': [983, 1017, 5051, 5085], 'Cycle.': [985, 5053], '4:': [987, 1043, 1794, 2779, 5055, 5111], '1593-1598Crossref': [988, 5056], '19Brady': [992, 5060], 'Yu': [994, 5062], '24:': [1005, 1022, 5073, 5090], '9327-9338Crossref': [1006, 5074], '(137)': [1009, 5077], '20Bertwistle': [1012, 5080], 'Sugimoto': [1014, 5082], '985-996Crossref': [1023, 5091], '(324)': [1026, 5094], '21Colombo': [1029, 5097], 'Marine': [1031, 5099], 'J.C.': [1032, 5100], 'Danovi': [1033, 5101], 'Pelicci': [1037, 1267, 1400, 5105], 'P.G.': [1038, 1268, 1401, 5106], '529-533Crossref': [1044, 5112], '(431)': [1047, 5115], '22Itahana': [1050, 5118], 'Bhat': [1052, 5120], 'K.P.': [1053, 5121], 'Itahana': [1056, 5124], 'Hawke': [1058, 5126], 'Kobayashi': [1060, 5128], 'Zhang': [1062, 5002, 5130], '12:': [1067, 5135], '1151-1164Abstract': [1068, 5136], '(386)': [1076, 5144], 'transcriptional': [1082], 'Myc': [1085], '(23Boon': [1086], 'Caron': [1088, 5149], 'H.N.': [1089, 5150], 'van': [1090, 1097, 2037, 5151, 5158], 'Asperen': [1091, 5152], 'Valentijn': [1093, 5154], 'Hermus': [1095, 5156], 'M.C.': [1096, 5157], 'Sluis': [1098, 5159], 'P.': [1099, 1256, 1389, 1437, 2217, 3722, 4058, 4818, 4862, 5160], 'Roobeek': [1100, 5161], 'I.': [1101, 1103, 1461, 3587, 3746, 4082, 4826, 5162, 5164], 'Weis': [1102, 5163], 'Voute': [1104, 5165], 'P.A.': [1105, 5166], 'Schwab': [1106, 5167], 'Versteeg': [1108, 5169], 'EMBO': [1110, 5171], '2001;': [1112, 1135, 5173, 5196], '20:': [1113, 3225, 5174], '1383-1393Crossref': [1114, 5175], '(334)': [1117, 5178], '24Zeller': [1120, 5181], 'K.I.': [1121, 5182], 'Haggerty': [1122, 5183], 'T.J.': [1123, 5184], 'Barrett': [1124, 5185], 'J.F.': [1125, 5186], 'Guo': [1126, 5187], 'Q.': [1127, 5188], 'Wonsey': [1128, 5189], 'D.R.': [1129, 5190], 'Dang': [1130, 5191], 'C.V.': [1131, 5192], '276:': [1136, 5197], '48285-48291Abstract': [1137, 5198], '(101)': [1145, 5206], 'signal': [1153, 1181, 3580, 4153, 4176, 4214, 5259], 'spectroscopy': [1157, 1168, 1173, 1185, 1196, 1201], 'enhanced': [1158, 1186, 2416], '4-morpholineethanesulfonic': [1162, 1190], 'acid': [1163, 1191, 4596], 'phosphate-buffered': [1164, 1192], 'saline': [1165, 1193], 'total': [1166, 1194], 'heteronuclear': [1169, 1197], '4-morpholinepropanesulfonic': [1174, 1202], 'cells': [1221, 2448, 2542, 3642, 4656], '(NPMc+': [1222], 'AML)': [1223], '(25Falini': [1224, 1357], 'Tiacci': [1228, 1361, 1442, 3727, 4063], 'Alcalay': [1230, 1363], 'Rosati': [1232, 1365, 1434, 3719, 4055], 'Pasqualucci': [1234, 1367, 1430, 3715, 4051], 'La': [1236, 1369], 'Starza': [1237, 1370], 'Diverio': [1239, 1372, 1438, 3723, 4059], 'Colombo': [1241, 1374], 'Santucci': [1243, 1376], 'Bigerna': [1245, 1378, 1428, 3591, 3713, 4049], 'Pacini': [1247, 1380], 'Pucciarini': [1249, 1382, 1426, 3593, 3711, 4047], 'Liso': [1251, 1384, 1424, 3599, 3709, 4045], 'Vignetti': [1253, 1386], 'Fazi': [1255, 1388], 'Meani': [1257, 1390], 'Pettirossi': [1259, 1392], 'V.': [1260, 1393], 'Saglio': [1261, 1394], 'Mandelli': [1263, 1396], 'F.': [1264, 1266, 1397, 1399, 1784, 2177, 3604], 'Lo-Coco': [1265, 1398], 'Martelli': [1269, 1402, 1422, 1454, 3597, 3605, 3707, 3739, 4043, 4075], 'M.F.': [1270, 1403, 1455, 3590, 3606, 3740, 4076], 'Engl.': [1272, 1331, 1405], 'Med.': [1274, 1333, 1407], '352:': [1276, 1335, 1409], '254-266Crossref': [1277, 1410], '(1386)': [1280, 1413], 'Two': [1283], 'consequences': [1284], 'mutation-related': [1286], 'sequence': [1287, 2613, 2684, 3199, 3302, 3323, 3329], 'changes': [1288], 'at': [1289, 1699, 1852, 2299, 2343, 2353, 2385, 2451, 2525, 2562, 3351, 3943, 4536], 'promote': [1295], 'NPMc+': [1304, 1546, 3373, 4225, 5023, 5248], 'First,': [1306], 'generation': [1307], 'additional': [1310, 1695, 2977, 4533], 'motif': [1314], 'reinforces': [1315], 'Crm1': [1316], '(XpoI)-dependent': [1317], '(26Nakagawa': [1324], 'Kameoka': [1326], 'Suzuki': [1328], '1819-1820PubMed': [1336], 'Second,': [1339], 'there': [1340, 3486], 'Trp288': [1346, 1515, 3532, 3546, 3675, 3798, 3834, 4094], 'Trp290': [1348, 1350, 1517, 3677, 3800, 3836, 4096], '(or': [1349], 'alone)': [1351], 'determine': [1353], '27Falini': [1416], 'Bolli': [1418, 3703, 4039], 'Shan': [1420, 3705, 4041], 'M.P.': [1423, 3598, 3708, 4044], 'Mannucci': [1432, 3595, 3717, 4053], 'Gorello': [1436, 3721, 4057], 'Roti': [1440, 3725, 4061], 'Cazzaniga': [1444, 3729, 4065], 'Biondi': [1446, 3731, 4067], 'Schnittger': [1448, 3733, 4069], 'Haferlach': [1450, 3735, 4071], 'T.': [1451, 1474, 1790, 1927, 2233, 3655, 3736, 3759, 4072], 'Hiddemann': [1452, 3737, 4073], 'Gu': [1456, 3741, 4077], 'Nicoletti': [1460, 3586, 3745, 4081], 'Blood.': [1462, 3747, 4083], '107:': [1464, 3749, 4085], '4514-4523Crossref': [1465, 3750, 4086], '(207)': [1468, 3753, 4089], '28Nishimura': [1471, 3756], 'Ohkubo': [1473, 3758], 'Furuichi': [1475, 3760], 'Umekawa': [1477, 3762], 'Biosci.': [1479, 3764], 'Biotechnol.': [1480, 3765], '66:': [1483, 3768], '2239-2242Crossref': [1484, 3769], '(66)': [1487, 3772], 'However,': [1490], 'precise': [1492], 'mechanisms': [1494, 1544], 'regulate': [1496], 'steady': [1498], 'state': [1499, 3502], 'distribution': [1500], 'study,': [1507], 'tested': [1509], 'hypothesis': [1511], 'structural': [1520, 1539, 2810, 4610], 'components': [1521], 'These': [1535, 3507, 5015], 'studies': [1536], 'provide': [1537], 'basis': [1540], 'understanding': [1542], 'Reagents—Mutants': [1548], 'W288A/W290A': [1550], 'F268A/F276A': [1553, 3970, 3997, 4004], 'were': [1554, 1579, 1604, 1619, 1730, 1735, 1761, 1803, 1808, 1819, 1830, 1850, 1859, 1870, 1895, 1912, 1947, 1969, 1994, 2050, 2063, 2087, 2111, 2145, 2193, 2252, 2280, 2292, 2360, 2396, 2408, 2425, 2477, 2491, 2517, 2543, 2568, 2581, 2744, 4267, 4280, 4438], 'made': [1555, 1666], 'site-directed': [1557], 'mutagenesis': [1558], 'E': [1563, 3337, 3411, 3441, 3481, 3543], 'PCR': [1565], 'appropriate': [1567], 'primers.': [1568], 'variants,': [1572], 'exception': [1575], 'A,': [1578, 3320, 3528], 'cloned': [1580, 2397, 2692], 'into': [1581, 2013, 2089, 2398, 3038, 3998, 4097], 'modified': [1583, 2429], 'pRSETA': [1584], 'vector': [1585, 2402], '(Invitrogen)': [1586, 2433, 2467], 'expressing': [1587], 'fused': [1590], 'tobacco': [1593, 1622], 'etch': [1594, 1623], 'virus': [1595, 1624], 'protease-cleavable': [1596], 'His6-tagged': [1597], 'lipoyl': [1598], 'from': [1600, 1805, 1821, 2083, 2147, 2348, 2618, 2666, 2831, 2930, 2947, 3046, 3086, 3125, 3476, 4009, 4168, 4177, 5251], 'Bacillus': [1601], 'stearothermophilus.': [1602], 'Proteins': [1603, 2759], 'Escherichia': [1607], 'coli': [1608], 'strain': [1609], 'C41': [1610], 'purified': [1612, 1683], 'Ni2+-chelating': [1614], 'affinity': [1615, 1632], 'chromatography.': [1616, 1689], 'Fusion': [1617], 'cleaved': [1620], 'protease': [1625], 'digestion': [1626], 'removed': [1628], 'second': [1631, 3052], 'step': [1633, 4717], 'before': [1634, 2442], 'concentration': [1635, 1746], 'final': [1637], 'purification': [1638, 1710, 2705], 'size': [1640], 'exclusion': [1641], 'chromatography': [1642], 'on': [1643, 1832, 2113, 2131, 2591, 3169, 3291, 3987, 4141, 4274, 4333, 4472, 4676], 'GF30': [1645], 'column': [1646, 2022], '(Amersham': [1647, 2023], 'Biosciences).': [1648, 2405], 'For': [1649, 2002], 'isotopic': [1650], 'labeling,': [1651], 'K-MOPS': [1652], 'minimal': [1653], 'media': [1654], 'containing': [1655, 2016, 2458, 3968], '15NH4Cl': [1656], 'and/or': [1657], '[13C]glucose': [1658], 'was': [1659, 1665, 1747, 2011, 2129, 2328, 2341, 2449, 2462, 2691, 2750, 3246, 4420, 4426, 4452], 'used.': [1660], 'Mutant': [1661, 3480, 3527, 4424], 'Liberty': [1669], 'CEM': [1670], 'microwave': [1671], 'peptide': [1672], 'synthesizer': [1673], '(Matthews,': [1674], 'NC)': [1675], 'standard': [1677, 2197, 2364, 2753], 'Fmoc': [1678], '(N-(9-fluorenyl)methoxycarbonyl)': [1679], '/t-butyl': [1680], 'chemistry': [1681], 'reverse-phase': [1685], 'high': [1686], 'pressure': [1687], 'liquid': [1688, 1884], 'All': [1690, 1801, 1906, 1943, 1963, 2058], 'constructs': [1692], 'glycine': [1697], 'N': [1701], 'cloning': [1708], 'strategy;': [1711], 'residue': [1712, 2151], 'numbering': [1713], 'context': [1716], 'full-length': [1719, 3992, 4195, 4410], 'omits': [1722], 'these': [1723, 2274, 3148, 3375, 3783, 3872, 3932, 3985, 4265, 4521, 4772], 'glycines.': [1724], 'SDS-PAGE': [1725, 2700], 'electrospray': [1727], 'mass': [1728, 1739], 'spectrometry': [1729, 2703], 'confirm': [1733], 'expected': [1738, 2712, 3475, 3817, 3906, 3964], 'assess': [1742], 'purity.': [1744], 'spectroscopically': [1749], 'Varian': [1752], 'Cary': [1753], '500': [1754], 'spectrometer': [1755], '(Varian,': [1756], 'NC),': [1757], 'extinction': [1759], 'coefficients': [1760], 'calculated': [1762, 2194], '280': [1764], 'nm': [1765, 2298, 2345], '(29Gill': [1766], 'S.C.': [1767], 'von': [1768], 'Hippel': [1769], 'P.H.': [1770], 'Anal.': [1771], '182:': [1774], '319-326Crossref': [1775], '(5010)': [1778], '30Pace': [1781], 'C.N.': [1782], 'Vajdos': [1783], 'Fee': [1785], 'Grimsley': [1787], 'Gray': [1789], '2411-2423Crossref': [1795], '(3373)': [1798], 'reagents': [1802], 'purchased': [1804, 1820], 'Sigma': [1806], 'Anal-R': [1809], 'grade': [1810], 'higher,': [1812], 'except': [1813], 'isotopically': [1815], 'enriched': [1816], 'reagents,': [1817], 'which': [1818, 3156, 3239, 3529, 3545, 3621, 4540], 'Cambridge': [1822], 'Isotopes': [1823], '(Cambridge,': [1824], 'UK).': [1825], 'Spectroscopic': [1826], 'Measurements—The': [1827], 'spectra': [1829, 1946, 2030, 2086, 2289, 2724, 2736, 3405, 3434], 'recorded': [1831, 1851, 2051, 2293, 2329], 'Bruker': [1833], 'Advance-800,': [1834], 'Advance-II+': [1835], '700,': [1836], 'Advance-600': [1838], 'spectrometers.': [1839], 'Two-dimensional': [1840], 'NOESY,': [1841], 'TOCSY,': [1842], 'DQF-COSY,': [1843], '15N-HSQC,': [1844], 'constant': [1845], 'time': [1846], '13C-HSQC': [1847], '13C-TOCSY': [1849], '298': [1853], 'mixing': [1856], 'times': [1857], 'chosen': [1858], '80': [1860], 'ms': [1861, 1866], 'TOCSY': [1863], '120': [1865], 'NOESY.': [1868], 'Spectra': [1869], 'referenced': [1871], 'relative': [1872], 'external': [1874], 'sodium': [1875, 1987], '2,2-dimethyl-2-silapentane-5-sulfonate': [1876], 'signals': [1878], 'proton': [1880], 'carbon,': [1882], 'ammonium': [1885], 'nitrogen.': [1889], 'Approximately': [1890], 'half': [1891], 'Hb': [1893], 'resonances': [1894, 1911], 'assigned': [1896, 1913], 'stereospecifically': [1897, 1914], 'combination': [1900], 'HNHB': [1902], 'DQF-COSY': [1904], 'spectra.': [1905], 'Val(Hγ)': [1908], 'Leu(Hδ)': [1910], '10%': [1917, 2436], '13C-labeled': [1918], 'sample': [1919], '(31Neri': [1924], 'Szyperski': [1926], 'Otting': [1928], 'Senn': [1930], 'Wuthrich': [1932], '7510-7516Crossref': [1937], '(563)': [1940], 'analyzed': [1948], 'Sparky': [1950], '(32Goddard': [1951], 'T.D.': [1952], 'Kneller': [1953], 'D.G.': [1954, 4926], 'SPARKY': [1955], '3.': [1956], 'University': [1957, 2387], 'California,': [1959], 'San': [1960], 'Francisco2007Google': [1961], 'samples': [1964, 1993], 'determination': [1968], '1.2': [1970], 'mm': [1971, 1976, 1981, 1984, 2069, 2074], 'prepared': [1973], '10': [1975], 'MES,': [1977], 'pH': [1978, 2071], '6.5,': [1979, 2072], '150': [1980, 2073, 2250], 'NaCl,': [1982, 2075], '5': [1983], 'dithiothreitol,': [1985], '0.02%': [1986], 'azide,': [1988], '5%': [1990, 2076], 'D2O': [1991, 2018], '(homonuclear': [1992], 'deuterated': [1997], 'version': [1998], 'buffer).': [2001], 'hydrogen': [2003, 2118, 2918], 'exchange': [2004], 'experiments,': [2005], '15N-labeled': [2007], 'exchanged': [2012], 'buffer': [2015, 2067, 2305, 2326], '100%': [2017], 'NAP-10': [2021], 'Biosciences),': [2024], 'series': [2027], '1H-15N-FHSQC': [2029], '(33Mori': [2031], 'Abeygunawardana': [2033], 'Johnson': [2035], 'Zijl': [2038], 'P.C.': [2039], 'Magn.': [2041], 'Reson.': [2042], '108:': [2044], '94-98Crossref': [2045], '(564)': [2047], 'over': [2052, 4493], 'course': [2054], '6': [2056], 'h.': [2057, 2531], 'one-dimensional': [2059, 2715, 3402, 3848], '1H': [2060, 2716, 3403, 3849], 'experiments': [2062, 2720], 'conducted': [2064], 'biophysics': [2066, 2304], '(10': [2068], 'KPi,': [2070], 'D2O).': [2077], 'Structure': [2078, 2604, 3293], 'Determination—The': [2079], 'distance': [2080, 2095, 2115, 2133, 2260, 2892], 'constraints': [2081, 2096, 2107, 2144, 2168, 2842], 'derived': [2082], 'NOESY': [2085], 'classified': [2088, 4312], 'four': [2090], 'categories': [2091], 'corresponding': [2092, 2685], 'inter-proton': [2094], '1.8-2.8,': [2098], '1.8-3.5,': [2099], '1.8-4.75,': [2100], '1.8-6.0': [2102], 'Å,': [2103, 2265], 'respectively.': [2104], 'Hydrogen': [2105], 'bond': [2106, 2874, 2919], '1.8-2.1': [2109], 'Å': [2110, 2128, 2801], 'imposed': [2112, 2130], 'acceptor': [2121, 2140], 'oxygen,': [2122], 'whereas': [2123, 3175, 3331, 3458], 'another': [2124, 5217], 'constraint': [2125], '2.7-3.1': [2127], 'donor': [2136], 'nitrogen': [2137], 'oxygen.': [2141], 'Torsion': [2142], 'angle': [2143, 2167, 2199, 2268, 2871], 'obtained': [2146], 'stereospecific': [2148], 'assignment': [2149], 'side': [2152, 4348], 'chains': [2153], 'incorporated': [2155], 'calculation,': [2159], 'along': [2160], 'backbone': [2163, 2803], 'φ': [2164], 'ψ': [2166], 'program': [2172, 2206, 3215], 'TALOS': [2173, 2926], '(34Cornilescu': [2174], 'Delaglio': [2176], 'Bax': [2178], 'Biomol.': [2181], 'NMR.': [2182, 4129], '289-302Crossref': [2185], '(2727)': [2188], 'structures': [2192, 2251, 2279, 2818, 2851], 'torsion': [2198], 'dynamics': [2200], 'simulated': [2201], 'annealing': [2202], 'protocol': [2203], 'CNS': [2207, 2902], '(35Brunger': [2208], 'A.T.': [2209], 'Adams': [2210], 'P.D.': [2211], 'Clore': [2212], 'G.M.': [2213], 'DeLano': [2214], 'W.L.': [2215], 'Gros': [2216], 'Grosse-Kunstleve': [2218], 'R.W.': [2219], 'Jiang': [2220], 'Kuszewski': [2222], 'Nilges': [2224], 'Pannu': [2226], 'N.S.': [2227], 'Read': [2228], 'R.J.': [2229], 'Rice': [2230], 'L.M.': [2231, 4957], 'Simonson': [2232], 'Warren': [2234, 4966], 'G.L.': [2235], 'Acta': [2236], 'Crystallogr.': [2237, 2241], 'Sect.': [2238], 'D': [2239], '54:': [2243], '905-921Crossref': [2244], '(16918)': [2247], 'accepted': [2253, 2815, 2850, 2877], 'out': [2254], '150,': [2256], 'produced': [2257, 2721], 'no': [2259, 2267, 3197, 3462, 3536, 4469], 'violations': [2261, 2269], 'greater': [2262, 2270], '0.25': [2264], '5°.': [2272], 'Of': [2273], '20': [2276, 2488, 2512, 2814, 2847], 'lowest': [2277, 2816, 2848], 'energy': [2278, 2817, 2849, 2903], 'selected': [2281], 'presentation': [2283], 'statistical': [2285], 'representation.': [2286], 'Circular': [2287], 'Dichroism—CD': [2288], '260': [2295], '190': [2297], '30-60': [2300], 'μm': [2301], 'Jasco-J815': [2308], 'spectropolarimeter': [2309], '(Jasco': [2310], 'Inc.,': [2311, 2767], 'Easton,': [2312], 'MD)': [2313], '1-mm': [2316], 'path': [2317], 'length': [2318], 'cuvette.': [2319], 'base': [2321], 'line': [2322, 4369], 'due': [2323], 'only': [2327], 'subtracted': [2331], 'prior': [2332, 2499], 'normalizing': [2334], 'data': [2336], 'concentration.': [2338], 'Thermal': [2339], 'denaturation': [2340, 2366], 'followed': [2342], '222': [2344], 'heating': [2347], '277': [2349], '371': [2351], 'K': [2352], 'rate': [2355], '1': [2357, 2530, 2549, 3021, 3361], 'K·min-1.': [2358], 'Data': [2359, 2834], 'fit': [2361], 'two-state': [2365], 'described': [2368, 4373], 'elsewhere': [2369], '(36Schmid': [2370], 'F.X.': [2371], 'Creighton': [2372], 'T.E.': [2373], 'Spectral': [2374], 'Methods': [2375], 'Characterizing': [2377], 'Conformation': [2379], 'Conformational': [2381], 'Changes.': [2382], 'IRL': [2383], 'Press': [2384], 'Oxford': [2386], 'Press,': [2388], 'Oxford,': [2389], 'UK1989:': [2390], '251-285Google': [2391], 'Immunofluorescence—Full-length': [2393], 'variants': [2395, 2407], 'mammalian': [2400, 3641], 'expression': [2401], 'pEGFP-C1': [2403], '(BD': [2404], 'thus': [2409, 4014, 4254], 'vivo': [2412], 'N-terminal': [2415, 2668, 4512], '(eGFP)': [2420], 'tag.': [2421], 'NIH-3T3': [2422, 3999], 'murine': [2423], 'fibroblasts': [2424], 'grown': [2426], "Dulbecco's": [2428], "Eagle's": [2430], 'medium': [2431], 'GlutaMAX™': [2432], 'supplemented': [2434], 'fetal': [2437, 2507], 'calf': [2438, 2508], 'serum.': [2439], 'day': [2441], 'transfection': [2443], 'confluent': [2445], 'flask': [2446], 'subcultured': [2450], '1:8': [2453], 'dilution': [2454], '6-well': [2456], 'plates': [2457], 'glass': [2459], 'coverslips.': [2460], 'Transfection': [2461], 'performed': [2463], 'Lipofectamine': [2465], '2000': [2466], 'per': [2469], "manufacturer's": [2471], 'instructions.': [2472], 'After': [2473, 2532], '24': [2474], 'h': [2475, 2550], 'coverslips': [2476, 2567], 'removed,': [2478], 'washed': [2479], 'PBS,': [2481], 'fixed': [2483], '4%': [2485], 'paraformaldehyde': [2486], 'min.': [2489], 'Cells': [2490, 2516], 'permeabilized': [2492], 'PBS': [2494, 2514, 2536], '+': [2495, 2537], '0.1%': [2496, 2538], 'Triton': [2497, 2539], 'X-100': [2498], 'blocking': [2501], '30': [2503], 'min': [2504], '20%': [2506], 'serum,': [2509], '0.5%': [2510], 'Tween': [2511], '(FATS).': [2515], 'stained': [2518], 'mouse': [2520], 'anti-fibrillarin': [2521], '(ab4566,': [2522], 'AbCam,': [2523], 'UK)': [2524], '1:500': [2526], 'FATS': [2528], 'three': [2533, 2649, 3161], 'washes': [2534], 'X-100,': [2540], 'incubated': [2544], 'dark': [2547], 'Alexa': [2552], 'Fluor™': [2553], '594-conjugated': [2554], 'goat': [2555], 'anti-mouse': [2556], 'antibody': [2557], '(Molecular': [2558], 'Probes,': [2559], 'Leiden,': [2560], 'Netherlands)': [2561], '1:200': [2563], 'FATS.': [2565], 'dried': [2569], 'air': [2571], 'mounted': [2573, 2590], 'Fluoromount-G™': [2575], '(Southern': [2576], 'Biotech,': [2577], 'Birmingham,': [2578], 'AL).': [2579], 'Images': [2580], 'collected': [2582], 'MRC-2000': [2585], 'plus': [2586], 'confocal': [2587], 'apparatus': [2588], '(Bio-Rad)': [2589], 'Nikon': [2593], 'eclipse': [2594], 'E800': [2595], 'microscope': [2596], '×60': [2599], 'oil': [2600], 'objective': [2601], 'lens.': [2602], 'Domain—Manual': [2609], 'inspection': [2610], 'NPM1,': [2615, 5223], 'assistance': [2617], 'secondary': [2620, 3539], 'prediction': [2622], 'tool': [2623], 'Jpred': [2624], '(37Cuff': [2625], 'J.A.': [2626], 'Clamp': [2627], 'M.E.': [2628], 'Siddiqui': [2629], 'A.S.': [2630], 'Finlay': [2631], 'Barton': [2633], 'G.J.': [2634], 'Bioinformatics': [2635], '(Oxf.).': [2636], '14:': [2638], '892-893Crossref': [2639], '(909)': [2642], 'indicated': [2645], 'potential': [2647, 2662, 4257, 5285], 'short': [2650, 2654], 'helices': [2651, 3358, 3948], 'separated': [2652, 2665], 'loops': [2655], 'within': [2656, 3953, 4145], 'last': [2658], '50': [2659], 'residues.': [2660, 4261], 'oligomerization': [2669], '∼120-residue': [2673], 'acid-rich': [2674], 'region': [2675, 2972, 2979, 2985, 4518, 4700], 'predicted': [2678, 3387], 'disordered.': [2681], 'DNA': [2683], '243-294': [2688], 'coli.': [2697], 'Inspection': [2698], 'electrospray-mass': [2702], 'following': [2704], 'pure': [2708], 'mass.': [2713], 'Both': [2714], '15N-HSQC': [2719], 'well': [2722, 2789, 3013], 'dispersed': [2723], 'characteristic': [2727, 4519], '(Fig.': [2732, 2805, 3018, 3099, 3185, 3343, 3420, 3811, 3864, 3956, 3977, 4012, 4252, 4339, 4441, 4475, 4695], '3A).': [2733, 3978], 'Ser243': [2739], 'Leu294': [2741], 'assigned,': [2745], 'solution': [2748], 'techniques': [2754], '(38Wüthrich': [2755], 'Acid.': [2762], 'John': [2763], 'Wiley': [2764], '&': [2765], 'Sons,': [2766], 'New': [2768], 'York1986Crossref': [2769], '39Bax': [2772], 'Curr.': [2774], 'Opin.': [2775], 'Struct.': [2776], '738-744Crossref': [2780], 'Residues': [2785, 4229], '244-294': [2786], 'adopt': [2787], 'defined': [2790, 3014], 'tertiary': [2791, 3427, 3843, 3975], 'root': [2795, 2882, 2991], 'mean': [2796, 2883, 2949, 2992], 'square': [2797, 2884, 2993], 'deviation': [2798], '0.4': [2800], 'atoms': [2804], '1A).': [2806], 'Experimental': [2807], 'restraints': [2808], 'statistics': [2811, 2844], 'summarized': [2820], 'Table': [2822], '1.': [2823], 'coordinates': [2825], 'available': [2830], 'Bank': [2835], '(entry': [2836], 'code': [2837], '2vxd).TABLE': [2838], '1Summary': [2839], 'conformational': [2841], 'nucleophosminStructural': [2856], 'constraintsIntra-residue823Sequential196Medium': [2857], 'range': [2858, 2865, 4292], '(2': [2859], '≥|i': [2860], '-': [2861, 2867], 'j|': [2862, 2868], '≥': [2863], '4)219Long': [2864], '(|i': [2866], '>': [2869], '4)118X1': [2870], 'constraints15ALOS': [2872], 'constraints77Hydrogen': [2873], 'constraints50Total1498Statistics': [2875], 'structuresStatistics': [2878], 'parameter': [2879], '(±S.D.)r.m.s.d.ar.m.s.d.': [2880], 'means': [2881, 2887, 2990, 2996], 'deviation;': [2885, 2994], 'NOE': [2886, 2995], 'effect.': [2890, 2999], 'constraints0.0084': [2893], '±': [2894, 2900, 2906, 2909, 2914, 2921, 2928, 2936, 2940, 2943, 2958, 2965], '0.0003': [2895], 'År.m.s.d.': [2896], 'dihedral': [2898, 2924], 'constraints0.345': [2899], '0.029°Mean': [2901], 'term': [2904], '(kcal·mol−1': [2905], 'S.D.)E': [2907], '(overall)50.3': [2908], '4.2E': [2910], '(van': [2911], 'der': [2912], 'Waals)15.8': [2913], '2.9E': [2915], '(NOE': [2916], 'constraints)3.1': [2920], '.2E': [2922], '(X-1': [2923], 'constraints)0.56': [2927], '0.1r.m.s.d.': [2929], 'ideal': [2932], 'geometry': [2933], '(±S.D.)Bond': [2934], 'lengths0.0015': [2935], '0.00009': [2937], 'ÅBond': [2938], 'angles0.32': [2939], '0.007°Improper': [2941], 'angles0.24': [2942], '0.013°Average': [2944], 'atomic': [2945], 'r.m.s.d.': [2946, 2989], '(±': [2951], 'S.D.)Residues': [2952], '3-54': [2953, 2961], '(N,': [2954], 'C-α,': [2955], 'atoms)0.40': [2957], '0.07': [2959], 'ÅResidues': [2960], '(all': [2962], 'heavy': [2963], 'atoms)0.94': [2964], '0.08': [2966], 'ÅStructural': [2967], 'qualityResidues': [2968], 'favored': [2971], 'Ramachandran': [2974, 2981, 2987], 'plot94.1%Residues': [2975], 'allowed': [2978], 'plot5.2%Residues': [2982], 'disallowed': [2984], 'plot0.3%a': [2988], 'Open': [3000], 'table': [3001], 'tab': [3005], 'forms': [3011], 'right-handed': [3015], '3-helix': [3016], 'bundle': [3017], '1B).': [3019], 'Helix': [3020, 3043], 'formed': [3023, 3072], 'Val244': [3026], 'Glu256,': [3028], 'Lys257': [3030], 'Gly258': [3032], 'then': [3033], 'forming': [3034], 'H-bonded': [3036], 'turn': [3037], 'first': [3040], 'loop': [3041, 3053, 3135, 3158], 'Gly259-Pro264.': [3042], '2': [3044, 3359], 'runs': [3045], 'Glu265': [3047], 'Phe276': [3049, 3114], 'until': [3050], 'Arg277-Asp280,': [3055], 'helix': [3057, 3310, 3355], '3': [3058, 3356], 'composed': [3060], 'Gln281': [3063], 'Lys292.': [3065], 'core': [3067, 3104, 3367, 3806, 3955], 'largely': [3073, 3106, 3550], 'aromatic': [3075], '(Tyr271,': [3077], 'Phe268,': [3078], 'Phe276,': [3079], 'Trp288,': [3080, 3109], 'Trp290)': [3082], 'further': [3084], 'contribution': [3085], 'Met251,': [3088], 'Ile255,': [3089], 'Leu261,': [3090], 'Val272,': [3091], 'Leu287.': [3093], 'Sequence': [3094], 'alignment': [3095], 'homologous': [3097], '2D)': [3100], 'reveals': [3101], 'hydrophobic': [3103, 3366, 3805, 3939], 'conserved,': [3107, 3937], 'Trp290,': [3110, 3534], 'Phe268': [3112], 'strictly': [3115, 3152, 3936, 4248], 'conserved.': [3116], 'Deletions,': [3117], 'seen': [3118], 'more': [3121, 4461], 'distantly': [3122], 'related': [3123], 'Lytechinus': [3126], 'pictus': [3127], 'Asterina': [3129], 'pectinifera,': [3130], 'confined': [3132], 'solely': [3133], '1,': [3136, 3159], 'it': [3138, 3338, 3574, 3777, 3814, 4120, 4139, 4286, 4575, 4589, 4605], 'highly': [3140], 'likely': [3141, 4587, 4661, 5211], 'fold': [3144], 'throughout': [3147, 4550], 'species.': [3149], 'Other': [3150], 'Pro262,': [3155], 'ends': [3157], 'lysines': [3162], 'follows:': [3164], 'Lys263': [3165, 4357, 4487], 'Lys267': [3167, 4489], 'cluster': [3168, 4329], 'surface': [3171, 4335, 4378, 4449], 'protein,': [3174, 3457], 'Lys248': [3176, 4283, 4310], 'form': [3179, 4289], 'salt': [3181, 4293], 'bridge': [3182, 4294], 'Asp286': [3184], '2C)': [3186], 'important.': [3191], 'significant': [3198, 3242, 4470], 'similarity': [3200, 4611], 'any': [3202, 3465, 3841, 3973, 4494], 'domain,': [3205], 'but': [3206, 3492], 'search': [3208], 'similar': [3211, 3472], 'DALI': [3216], '(40Holm': [3217], 'Sander': [3219], '478-480Abstract': [3226], '(1268)': [3232], 'returned': [3235], 'matches,': [3237], 'among': [3238], 'recently': [3248], 'published': [3249], 'archaeal': [3250], 'ribosomal': [3251, 4613, 4724, 4750, 4788, 4982], 'S17e': [3253, 4615], '(41Wu': [3254], 'Yee': [3256], 'Huang': [3258], 'Y.J.': [3259], 'Ramelot': [3260], 'T.A.': [3261], 'Cort': [3262], 'J.R.': [3263], 'Semesi': [3264], 'Jung': [3266], 'J.W.': [3267], 'Lee': [3268], 'Montelione': [3270], 'G.T.': [3271], 'Kennedy': [3272], 'M.A.': [3273], 'Arrowsmith': [3274], 'C.H.': [3275], '2008;': [3278, 4876], '17:': [3279], '583-588Crossref': [3280], '(3)': [3283], 'Effect': [3286], 'Leukemia': [3289], 'Domain—NPMc+': [3298], 'alter': [3300], 'third': [3309], 'mutation,': [3318], 'wild-type': [3322, 4185, 4465], 'WQWRKSL': [3324], 'replaced': [3326, 3340, 3378], 'CLAVEEVSLRK,': [3330], 'less': [3334], 'WQS-LAQVSLRK': [3342], '3C).': [3344], 'Several': [3345, 4778], 'altered': [3348], 'interface': [3353], 'contribute': [3363], 'domain.': [3370, 3392, 4672, 5269], 'mutants,': [3374], 'smaller': [3380], 'amino': [3381], 'acids,': [3382], 'would': [3385, 3815, 3821, 3867, 3904], 'greatly': [3389], 'destabilize': [3390], 'To': [3393, 3775, 3889, 3915, 4262], 'test': [3394, 3890], 'hypothesis,': [3396, 3892], 'spectroscopy.': [3400], 'show': [3412, 5239], 'decrease': [3414], 'dispersion': [3416], 'compared': [3417, 3959], 'NPM1wt': [3419, 3436, 3447], '3A),': [3421], 'indicative': [3422], 'Fig.': [3429, 3852, 3961], '3B': [3430], 'shows': [3431, 3461, 3482], 'CD': [3433, 4127], 'function': [3444, 4144], 'temperature.': [3446], 'describes': [3448], 'sigmoidal': [3450], 'unfolding': [3451, 3860], 'transition': [3452, 3467, 3861], 'typical': [3453], 'evidence': [3463, 3488, 4768], 'such': [3466, 4307], 'yields': [3469], 'trace': [3471], 'unstructured': [3478], 'protein.': [3479], 'intermediate': [3484], 'response;': [3485], 'transition,': [3491], 'never': [3495], 'fully': [3498], 'occupy': [3499], 'wild': [3505], 'type.': [3506], 'results': [3508, 5235, 5250], 'suggest': [3509, 3868], 'lead': [3516, 3686, 3822, 4775], 'destabilization': [3519], 'lacks': [3530, 3840, 3972], 'residual': [3537], 'regular': [3538], 'Interestingly,': [3541, 4673], '(in': [3544], 'retained),': [3548], 'although': [3549], 'destabilized,': [3551], 'clearly': [3553], 'not': [3554, 3779, 3856, 4323, 4402, 4583], 'completely': [3555, 3624, 4439], 'unstructured.': [3556], 'retain': [3560], 'some': [3561], 'ability': [3562], 'localize': [3564], 'could': [3571, 5282], 'explain': [3572], 'why': [3573], 'stronger': [3577], '(42Bolli': [3584], 'De': [3588], 'Marco': [3589], 'Fabbiano': [3603], 'Henderson': [3607], 'B.R.': [3608], 'Cancer': [3611], '2007;': [3613, 4646, 4807, 4970, 5007], '67:': [3614], '6230-6237Crossref': [3615], '(86)': [3618], 'itself': [3622], 'unfolded.': [3625], 'Folded': [3627], 'Domain': [3629, 4233], 'Is': [3630], 'Required': [3631], 'Nucleolar': [3633], 'Targeting—Expressing': [3634], 'eGFP': [3638], 'fusion': [3639], 'allows': [3643, 4138], 'direct': [3646], 'observation': [3647], 'its': [3649, 3909, 4142, 4537, 4571, 4761, 5267], 'subcellular': [3650, 3988], '(43Dundr': [3652], 'Misteli': [3654], '150:': [3662], '433-446Crossref': [3663], 'manner': [3671], 'mutation': [3673, 3820, 3870, 4299, 4354], 'alanine': [3679, 3839, 3927], 'been': [3683, 3780, 4031, 4624, 4988], 'shown': [3684, 3796, 4528, 4625, 4688], 'accumulation': [3694, 5244], 'nucleus': [3700], '(27Falini': [3701, 4037], 'clear': [3781], 'how': [3782], 'contributed': [3785], 'direction': [3788], 'nucleolus.': [3793, 4106], 'We': [3794, 3979, 4107], 'part': [3802], '2A),': [3812], 'Indeed,': [3828], 'distinct': [3842, 3974], '(as': [3845], 'judged': [3846, 4125, 4343], 'NMR;': [3850], 'see': [3851], '3A)': [3853], 'does': [3855], 'undergo': [3857], 'cooperative': [3859], 'when': [3862], 'heated': [3863], '3B).': [3865], 'prevents': [3874], 'simply': [3877], 'preventing': [3879], 'correct': [3881], 'folding': [3882], 'decided': [3894], 'make': [3896, 3950], 'other': [3897, 5037], 'disrupt': [3908], 'while': [3911, 4148], 'retaining': [3912], 'tryptophans.': [3914], 'end': [3917, 4183], 'chose': [3919], 'mutate': [3921], 'phenylalanines': [3922], '268': [3923], '276': [3925], '(F268A': [3928], 'F276A)': [3930], 'large': [3938], 'pack': [3942], 'interfaces': [3945], 'many': [3951], 'contacts': [3952], '2B,': [3957], '2A).': [3962], 'As': [3963, 4443], 'next': [3980], 'examined': [3981], 'effects': [3983, 4273, 4374], 'transfecting': [3991], 'protein-tagged': [3995], 'eGFP-NPM1': [4003], 'excluded': [4008], '4),': [4013], 'proving': [4015], 'property': [4021], 'whole.': [4028], 'It': [4029, 4585, 4659, 5209], 'reported': [4032, 4989], 'et': [4035], 'al.': [4036], 're-inserting': [4093], 'leads': [4100, 4308], 'complete': [4102], 'relocalization': [4103], 'investigated': [4108], 'C288W/A290W': [4116], 'construct': [4117, 4196], 'folded,': [4123], 'Presumably,': [4130], 'refolding': [4131], 'carry': [4140], 'unavailable': [4154], 'machinery.': [4158], 'Hence,': [4159], 'better': [4161], 'distinguish': [4162], 'NES': [4167], 'targeting,': [4170], 'added': [4172], '(LAVEEVSLRK)': [4180], 'GGS': [4190], 'linker': [4191], 'nucleolar.': [4199], 'indicates': [4201], 'addition': [4209], 'cause': [4218], 'observed': [4223], 'Functionally': [4227], 'Important': [4228], 'NPM1—Within': [4235], '248,': [4243], '263,': [4244], '267': [4246, 4328], '5),': [4253], 'indicating': [4255], 'examine': [4263], 'this,': [4264], 'alanine,': [4270], 'monitored.': [4281], 'Although': [4282, 4546], 'surface-exposed,': [4285], 'long': [4291], 'Asp286.': [4296], 'Indeed': [4297], 'K248A': [4300], 'significantly': [4301], 'destabilizes': [4302], 'being': [4311, 4319], 'opposed': [4317], 'directly': [4320], 'functional': [4321, 4483], '(data': [4322], 'shown).': [4324], 'Lysines': [4325], '263': [4326], 'orientate': [4331], 'freely': [4332, 4447], '5,': [4340], 'lack': [4346], 'chain': [4349], 'effects),': [4352], 'either': [4356], 'Lys267,': [4359], 'both,': [4361], 'increases': [4362], 'previously': [4372], 'removing': [4376], 'unpaired': [4377], 'charges': [4379], '(44Serrano': [4380], 'Horovitz': [4382], 'Avron': [4384], 'Bycroft': [4386], 'Fersht': [4388], 'A.R.': [4389], '1990;': [4391], '29:': [4392], '9343-9352Crossref': [4393], '(357)': [4396], 'Once': [4399], 'established': [4400], 'detrimental,': [4404], 'K263A,': [4413], 'K267A,': [4414], 'double': [4417, 4436], 'K263A/K267A': [4419], 'studied': [4421], 'vivo.': [4423], 'K263A': [4425], 'partially': [4427], 'delocalized': [4428, 4440], 'nucleoplasm,': [4431], 'K267A': [4433], '6).': [4442, 4476], 'control,': [4445], 'orienting': [4448], 'Lys250': [4451], 'mutated.': [4454], 'K250A': [4458], 'was,': [4459], 'predictably,': [4460], 'stable': [4462], 'yet': [4467], 'had': [4468], 'emphasizes': [4480], 'specific': [4482], 'requirement': [4484], 'nonspecific': [4495], 'charge': [4496], 'effects.': [4497], 'Nucleophosmin': [4498], 'member': [4501], 'chaperones': [4508], 'shares': [4510], 'pentamerization': [4513], 'central': [4516], 'acidic': [4517], 'proteins.': [4522], 'terminus,': [4539], 'unique': [4542], 'subfamily.': [4545], 'nucleus,': [4552], 'How': [4574], 'directs': [4576], 'clear.': [4584], 'seems': [4586, 4660, 5210], 'binds': [4590, 5026, 5222], 'ligand': [4597, 4707], 'possible': [4607], 'significant.': [4618], 'natural': [4620, 4667], 'product': [4621], 'avrainvillamide': [4622, 4663], 'bind': [4627], 'Cys275': [4635, 4674], '(45Wulff': [4636], 'Siegrist': [4638], 'Myers': [4640], 'A.G.': [4641], 'Am.': [4643, 4931], 'Soc.': [4645], '129:': [4647], '14444-14451Crossref': [4648], '(65)': [4651], 'sensitizes': [4655], 'apoptosis.': [4658], 'competes': [4664], 'binding': [4668, 4984], 'partner': [4669], 'same': [4678], 'face': [4679], '5)': [4696], 'suggesting': [4697], 'involved': [4705], 'binding.': [4708], 'Ribosome': [4709], 'metabolically': [4712], 'expensive': [4713], 'rate-limiting': [4716], 'cell': [4719, 5041], 'division': [4720], 'growth.': [4722], 'Consequently,': [4723], 'integrity': [4725], 'closely': [4727], 'monitored': [4728], 'variety': [4731], 'pathways': [4733, 4773, 5016, 5038], '(46Ruggero': [4734], '3:': [4742], '179-192Crossref': [4743], '(764)': [4746], 'Free': [4749], 'proteins,': [4751], 'example,': [4753, 4782], 'activate': [4754], 'p53': [4758], 'inhibiting': [4760], 'negative': [4762], 'regulator': [4763], 'MDM2.': [4764], 'There': [4765], 'growing': [4767], 'defects': [4770], 'can': [4774], 'disease.': [4777], 'blood': [4779], 'disorders,': [4780], 'caused': [4784], 'factors': [4794], '(47Cmejla': [4795], 'Cmejlova': [4797], 'Handrkova': [4799], 'Petrak': [4801], 'Pospisilova': [4803], 'Hum.': [4805, 4933], 'Mutat.': [4806], '1178-1182Crossref': [4809], '(186)': [4812], '48Draptchinskaia': [4815], 'Gustavsson': [4817], 'Andersson': [4819], 'Pettersson': [4821], 'Willig': [4823], 'T.N.': [4824], 'Dianzani': [4825], 'Ball': [4827, 4900], 'Tchernia': [4829, 4909], 'Klar': [4831], 'Matsson': [4833], 'Tentler': [4835], 'Mohandas': [4837], 'Carlsson': [4839], 'Dahl': [4841], 'Genet.': [4844, 4934, 4969], '21:': [4846], '169-175Crossref': [4847], '(661)': [4850], '49Ebert': [4853], 'B.L.': [4854], 'Pretz': [4855], 'Bosco': [4857], 'Chang': [4859], 'C.Y.': [4860], 'Tamayo': [4861], 'Galili': [4863], 'Raza': [4865], 'Root': [4867], 'D.E.': [4868], 'Attar': [4869], 'Ellis': [4871], 'S.R.': [4872], 'Golub': [4873], 'T.R.': [4874], '451:': [4877], '335-339Crossref': [4878], '(726)': [4881], '50Gazda': [4884], 'H.T.': [4885], 'Grabowska': [4886], 'Merida-Long': [4888], 'Latawiec': [4890], 'Schneider': [4892], 'H.E.': [4893], 'Lipton': [4894], 'J.M.': [4895], 'Vlachos': [4896], 'Atsidaftos': [4898], 'Orfali': [4902], 'K.A.': [4903], 'Niewiadomska': [4904], 'Da': [4906], 'Costa': [4907], 'Niemeyer': [4911], 'Meerpohl': [4913], 'J.J.': [4914], 'Stahl': [4915], 'Schratt': [4917], 'Glader': [4919], 'Backer': [4921], 'Wong': [4923, 4954], 'Nathan': [4925], 'Beggs': [4927], 'Sieff': [4929], 'C.A.': [4930], '79:': [4936], '1110-1118Abstract': [4937], '(225)': [4945], '51Menne': [4948], 'T.F.': [4949], 'Goyenechea': [4950], 'Sanchez-Puig': [4952], 'C.C.': [4955], 'Tonkin': [4956], 'Ancliff': [4958], 'P.J.': [4959], 'Brost': [4960], 'Costanzo': [4962], 'Boone': [4964], '39:': [4971], '486-495Crossref': [4972], '(236)': [4975], 'prevent': [4981], 'MDM2': [4986], 'human': [4991], 'cancers': [4992], '(52Lindstrom': [4993], 'Deisenroth': [4997], 'White': [4999], 'Wolf': [5000], '27:': [5008], '1056-1068Crossref': [5009], '(113)': [5012], 'seem': [5018], 'p19/ARF': [5029], 'regulated': [5035], 'control': [5040], 'growth': [5042], '23Boon': [5147], 'misdirection': [5213], 'p19ARF,': [5215], 'key': [5218, 5230], 'regulatory': [5219], 'molecule': [5220], 'play': [5228], 'gain': [5254], 'disruption': [5262], 'Molecules': [5270], 'interfere': [5278], 'mislocalization': [5281], 'therefore': [5283], 'applications': [5286], 'therapy.': [5289]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2030173743', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-16T16:37:53.607801', 'created_date': '2016-06-24'}