Publication Information

{'id': 'https://openalex.org/W2030145184', 'doi': 'https://doi.org/10.1038/sj.bjc.6603463', 'title': 'Cancer biology: mechanism of antitumour action of vorinostat (suberoylanilide hydroxamic acid), a novel histone deacetylase inhibitor', 'display_name': 'Cancer biology: mechanism of antitumour action of vorinostat (suberoylanilide hydroxamic acid), a novel histone deacetylase inhibitor', 'publication_year': 2006, 'publication_date': '2006-12-01', 'ids': {'openalex': 'https://openalex.org/W2030145184', 'doi': 'https://doi.org/10.1038/sj.bjc.6603463', 'mag': '2030145184', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2360770'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.bjc.6603463', 'pdf_url': 'https://www.nature.com/articles/6603463.pdf', 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.nature.com/articles/6603463.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027363771', 'display_name': 'Victoria M. Richon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'V M Richon', 'raw_affiliation_strings': ['Department of Cancer Biology and Therapeutics, Merck Research Laboratories, Boston, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology and Therapeutics, Merck Research Laboratories, Boston, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5027363771'], 'corresponding_institution_ids': ['https://openalex.org/I1285764155'], 'apc_list': {'value': 3790, 'currency': 'EUR', 'value_usd': 4690, 'provenance': 'doaj'}, 'apc_paid': {'value': 3790, 'currency': 'EUR', 'value_usd': 4690, 'provenance': 'doaj'}, 'fwci': 3.222, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 214, 'citation_normalized_percentile': {'value': 0.927411, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '95', 'issue': 'S1', 'first_page': 'S2', 'last_page': 'S6'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9827, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9347, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vorinostat', 'display_name': 'Vorinostat', 'score': 0.98162746}, {'id': 'https://openalex.org/keywords/hydroxamic-acid', 'display_name': 'Hydroxamic acid', 'score': 0.6225494}, {'id': 'https://openalex.org/keywords/histone-deacetylase-inhibitor', 'display_name': 'Histone deacetylase inhibitor', 'score': 0.60750943}, {'id': 'https://openalex.org/keywords/romidepsin', 'display_name': 'Romidepsin', 'score': 0.5364284}, {'id': 'https://openalex.org/keywords/depsipeptide', 'display_name': 'Depsipeptide', 'score': 0.5141914}, {'id': 'https://openalex.org/keywords/histone-deacetylase-5', 'display_name': 'Histone deacetylase 5', 'score': 0.44089216}], 'concepts': [{'id': 'https://openalex.org/C2776262904', 'wikidata': 'https://www.wikidata.org/wiki/Q905901', 'display_name': 'Vorinostat', 'level': 5, 'score': 0.98162746}, {'id': 'https://openalex.org/C2778305200', 'wikidata': 'https://www.wikidata.org/wiki/Q174378', 'display_name': 'Histone deacetylase', 'level': 4, 'score': 0.73110414}, {'id': 'https://openalex.org/C119157956', 'wikidata': 'https://www.wikidata.org/wiki/Q796604', 'display_name': 'Acetylation', 'level': 3, 'score': 0.63153327}, {'id': 'https://openalex.org/C2776281265', 'wikidata': 'https://www.wikidata.org/wiki/Q420327', 'display_name': 'Hydroxamic acid', 'level': 2, 'score': 0.6225494}, {'id': 'https://openalex.org/C2776202225', 'wikidata': 'https://www.wikidata.org/wiki/Q3569101', 'display_name': 'Histone deacetylase inhibitor', 'level': 5, 'score': 0.60750943}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.58602387}, {'id': 'https://openalex.org/C2781462825', 'wikidata': 'https://www.wikidata.org/wiki/Q7363205', 'display_name': 'Romidepsin', 'level': 5, 'score': 0.5364284}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.51640826}, {'id': 'https://openalex.org/C168831097', 'wikidata': 'https://www.wikidata.org/wiki/Q413248', 'display_name': 'Depsipeptide', 'level': 2, 'score': 0.5141914}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5046216}, {'id': 'https://openalex.org/C27253355', 'wikidata': 'https://www.wikidata.org/wiki/Q18034954', 'display_name': 'Histone deacetylase 5', 'level': 5, 'score': 0.44089216}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3671327}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34374025}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.33356196}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.06498182}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.bjc.6603463', 'pdf_url': 'https://www.nature.com/articles/6603463.pdf', 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360770', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.bjc.6603463', 'pdf_url': 'https://www.nature.com/articles/6603463.pdf', 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.67, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1486948598', 'https://openalex.org/W1511815964', 'https://openalex.org/W1812576394', 'https://openalex.org/W1898424879', 'https://openalex.org/W1920958927', 'https://openalex.org/W1935102817', 'https://openalex.org/W1969323007', 'https://openalex.org/W1973899902', 'https://openalex.org/W1978567987', 'https://openalex.org/W1978664410', 'https://openalex.org/W1982342754', 'https://openalex.org/W1990801507', 'https://openalex.org/W2003837981', 'https://openalex.org/W2003907016', 'https://openalex.org/W2004440602', 'https://openalex.org/W2008054969', 'https://openalex.org/W2017340736', 'https://openalex.org/W2021577923', 'https://openalex.org/W2022285476', 'https://openalex.org/W2023437193', 'https://openalex.org/W2045077330', 'https://openalex.org/W2087545262', 'https://openalex.org/W2090906911', 'https://openalex.org/W2094979409', 'https://openalex.org/W2103721535', 'https://openalex.org/W2106066245', 'https://openalex.org/W2121296685', 'https://openalex.org/W2123245958', 'https://openalex.org/W2135619784', 'https://openalex.org/W2135830745', 'https://openalex.org/W2140204965', 'https://openalex.org/W2150118183', 'https://openalex.org/W2151445954', 'https://openalex.org/W2158463669', 'https://openalex.org/W2162438863', 'https://openalex.org/W2167118090', 'https://openalex.org/W2286822649', 'https://openalex.org/W2319045291', 'https://openalex.org/W2331221462', 'https://openalex.org/W2345727187', 'https://openalex.org/W2408879707', 'https://openalex.org/W2462959074', 'https://openalex.org/W3148685323', 'https://openalex.org/W4211075966', 'https://openalex.org/W4242138200', 'https://openalex.org/W92697522'], 'related_works': ['https://openalex.org/W4361954153', 'https://openalex.org/W4361947815', 'https://openalex.org/W3036806196', 'https://openalex.org/W2324880737', 'https://openalex.org/W2098436600', 'https://openalex.org/W2075351620', 'https://openalex.org/W2067249550', 'https://openalex.org/W2066201695', 'https://openalex.org/W2060012433', 'https://openalex.org/W1968356004'], 'abstract_inverted_index': {'Histone': [0], 'deacetylase': [1], '(HDAC)': [2, 190], 'inhibitors': [3], 'represent': [4], 'a': [5, 19, 101, 133], 'potential': [6], 'new': [7], 'class': [8], 'of': [9, 22, 45, 53, 69, 103, 107, 135, 141, 151, 179], 'antitumor': [10], 'agents.': [11], 'Vorinostat': [12, 125], '(suberoylanilide': [13], 'hydroxamic': [14], 'acid': [15], 'or': [16, 98, 109, 119, 130], 'SAHA)': [17], 'is': [18], 'potent': [20], 'inhibitor': [21], 'HDAC': [23, 77], 'activity': [24, 78, 87, 205], 'and': [25, 34, 76, 159, 165, 169, 181, 195, 214], 'has': [26, 88, 206], 'undergone': [27], 'initial': [28], 'evaluation': [29], 'in': [30, 73, 84, 100, 132, 191, 209], 'several': [31], 'Phase': [32, 167], 'I': [33, 168], 'II': [35, 170], 'clinical': [36], 'trials.': [37], 'HDACs': [38, 65, 112], 'are': [39, 143, 201], 'enzymes': [40], 'that': [41, 184, 200], 'catalyse': [42], 'the': [43, 46, 50, 56, 67, 155, 176], 'removal': [44], 'acetyl': [47], 'moiety': [48], 'from': [49], 'lysine': [51], 'residues': [52], 'proteins,': [54, 153], 'including': [55, 105, 154], 'core': [57, 156], 'nucleosomal': [58, 157], 'histones.': [59], 'Together': [60], 'with': [61, 121, 211], 'histone': [62], 'acetyltransferases': [63], '(HATs),': [64], 'regulate': [66], 'level': [68], 'protein': [70], 'acetylation.': [71], 'Alterations': [72], 'both': [74, 212], 'HAT': [75, 86], 'have': [79, 113, 172], 'been': [80, 89, 114, 173, 207], 'reported': [81], 'to': [82, 91, 116, 145, 148], 'occur': [83], 'cancer.': [85], 'found': [90, 115], 'be': [92, 117, 146], 'disrupted': [93], 'by': [94], 'translocation,': [95], 'amplification,': [96], 'overexpression': [97], 'mutation': [99], 'variety': [102, 134], 'cancers,': [104], 'those': [106], 'haematological': [108, 213], 'epithelial': [110], 'origin.': [111], 'overexpressed': [118], 'associated': [120], 'oncogenic': [122], 'transcription': [123], 'factors.': [124], 'induces': [126], 'growth': [127], 'arrest,': [128], 'differentiation': [129], 'apoptosis': [131], 'transformed': [136], 'cells.': [137], 'The': [138], 'antiproliferative': [139], 'effects': [140], 'vorinostat': [142, 185], 'believed': [144], 'due': [147], 'drug-induced': [149], 'accumulation': [150], 'acetylated': [152], 'histones': [158], 'other': [160], 'proteins': [161], '(e.g.,': [162], 'BCL6,': [163], 'p53': [164], 'Hsp90).': [166], 'trials': [171], 'conducted': [174], 'for': [175], 'oral': [177], 'formulations': [178], 'vorinostat,': [180], 'results': [182], 'show': [183], 'inhibits': [186], 'its': [187], 'target': [188], 'enzyme': [189], 'peripheral': [192], 'mononuclear': [193], 'cells': [194], 'tumour': [196], 'tissue': [197], 'at': [198], 'doses': [199], 'well': [202], 'tolerated.': [203], 'Antitumour': [204], 'seen': [208], 'patients': [210], 'solid': [215], 'tumours.': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2030145184', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 18}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 18}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-07T16:26:10.054834', 'created_date': '2016-06-24'}