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[1023, 1474], 'Clark': [1024], 'Cramer': [1026], 'RD,': [1027], 'Vanopdenbosch': [1028], '1989.': [1030], 'Validation': [1031], 'general-purpose': [1034], 'Tripos': [1035], '5.2': [1036], 'force-field.': [1037], 'Comput': [1039], 'Chem': [1040, 1163, 1385, 2096], '10:': [1041, 1672, 1872, 1924], '982–': [1042], '1012.': [1043], 'M.': [1047, 1170, 1992], '1993.': [1048, 1365, 1513], 'mutation.': [1051], 'Oxford:': [1052], 'BIOS': [1053], 'Scientific': [1054], 'Publishers.': [1055], 'De': [1056], 'Filippis': [1057], 'Sander': [1059], 'Vriend': [1061, 1965], 'G.': [1062, 1966], '1994.': [1063, 1224, 1705], 'structural': [1066, 1115, 1131, 1326, 1664, 1833, 1914], 'result': [1069], 'point': [1071], 'mutations.': [1072, 1343, 1668], 'Eng': [1074, 1345, 1923], '7:': [1075, 1274], '1203–': [1076], '1208.': [1077], 'Denton': [1078], 'Marshall': [1080], 'C.': [1081, 1600, 1633], 'Laws': [1083], 'form': [1085], 'revisited.': [1086], 'Nature': [1087], '410:': [1088], '417.': [1089], 'Erlandsen': [1090, 1125, 1143], 'Fusetti': [1092, 1141], 'F,': [1093, 1142], 'Martinez': [1094], 'Hough': [1096], 'E,': [1097, 1396, 1990], 'Flatmark': [1098, 1145], 'T,': [1099, 1146, 1392, 1538, 1577, 1821, 1827], 'Stevens': [1100, 1127, 1147], 'RC.': [1101, 1128, 1148], 'Crystal': [1103, 1547], 'structure': [1104, 1369, 1548, 1595, 1779], 'catalytic': [1107], 'domain': [1108, 2005], 'reveals': [1113], 'phenylketonuria.': [1118, 1134, 1160, 1438], 'Nat': [1119], '4:': [1122], '995–': [1123], '1000.': [1124], 'Metab': [1137, 1308, 2061], '68:': [1138], '103–': [1139], '125.': [1140], '1998.': [1149, 1452, 1546, 1769], 'Structure': [1150], 'tetrameric': [1152], 'its': [1157], 'implications': [1158], '273:': [1164], '16962–': [1165], '16967.': [1166], 'Gilis': [1167], 'Rooman': [1169], 'stability': [1174, 1335, 1735, 1907], 'upon': [1176], 'using': [1178], 'database-derived': [1179], 'potentials:': [1180], 'determines': [1183], 'versus': [1188], 'non-local': [1189], 'interactions': [1190], 'along': [1191], 'sequence.': [1193], '272:': [1197], '276–': [1198], '290.': [1199], 'Grantham': [1200], 'R.': [1201], '1974.': [1202], 'Amino': [1203], 'formula': [1206], 'help': [1208], 'evolution.': [1211], 'Science': [1212], '185:': [1213], '862–': [1214], '864.': [1215], 'Greengard': [1216], 'JS,': [1217], 'Fisher': [1218], 'CL,': [1219], 'Villoutreix': [1220], 'B,': [1221, 1694], 'Griffin': [1222], 'JH.': [1223], 'Structural': [1225, 1424], 'I': [1229], 'II': [1232], 'deficiencies': [1233], 'antithrombotic': [1235], 'plasma': [1236], 'C:': [1238], 'patterns': [1239], 'revealed': [1240], 'three-dimensional': [1242], 'modelling': [1244, 1262], 'protease': [1249], 'domain.': [1250], 'Proteins': [1251, 1273], 'Funct': [1253], '18:': [1255], '367–': [1256], '380.': [1257], 'Greer': [1258], 'J.': [1259, 1933, 2016], '1990.': [1260, 1967], 'Comparative': [1261], 'methods:': [1263], 'applications': [1264], 'family': [1267], 'mammalian': [1270], 'serine': [1271], 'proteases.': [1272], '317–': [1275], '334.': [1276], 'Pedersen': [1283, 1879], 'CB,': [1284], 'L.': [1288, 1364, 1657], 'role': [1291], 'chaperone-assisted': [1293], 'folding': [1294, 1304, 1884], 'quality': [1296, 1521], 'control': [1297], 'inborn': [1299], 'errors': [1300], 'metabolism:': [1302], 'disorders.': [1305], 'Inher': [1307], 'Dis': [1309], '24:': [1310], '189–': [1311], '212.': [1312], 'Gromiha': [1313], 'Oobatake': [1315], 'Kono': [1317], 'Uedaira': [1319], 'Sarai': [1321], 'Role': [1324], 'information': [1329, 1496], 'prediction': [1332], 'changes:': [1336], 'comparison': [1337], 'buried': [1339, 1342], 'partially': [1341], '12:': [1346], '549–': [1347], '555.': [1348], 'Hamilton': [1349], 'JA,': [1350, 1762], 'Steinrauf': [1351], 'LK,': [1352], 'Braden': [1353], 'BC,': [1354], 'Liepnieks': [1355], 'Benson': [1357], 'MD,': [1358], 'Holmgren': [1359], 'Sandgren': [1361], 'O,': [1362], 'Steen': [1363], 'X-ray': [1367, 1742], 'crystal': [1368, 1594], 'refinements': [1370], 'normal': [1372], 'amyloidogenic': [1377, 1408], 'Val-30-Met': [1378], 'variant': [1379], '1.7-Å': [1381], 'resolution.': [1382, 1746], '268:': [1386], '2416–': [1387], '2424.': [1388], 'Hornberg': [1389], 'Eneqvist': [1391], 'Olofsson': [1393], 'Lundgren': [1395], 'Sauer-Eriksson': [1397], 'AE.': [1398], 'comparative': [1401], '23': [1404], 'transthyretin.': [1410], '302:': [1414], '649–': [1415], '669.': [1416], 'Jennings': [1417], 'IG,': [1418], 'Cotton': [1419], 'RGH,': [1420], 'Kobe': [1421], 'B.': [1422], 'interpretation': [1425], 'aids': [1432], 'identifying': [1434], 'genotype–phenotype': [1435], 'correlations': [1436], 'Eur': [1439], '8:': [1443, 1980], '696.': [1445], 'Ball': [1448, 1477], 'EV,': [1449, 1478], 'DN.': [1451, 1488], 'Neighboring': [1453], 'effects': [1455, 1997], 'rates': [1458], 'germline': [1460], 'genes.': [1467], '63:': [1472], '474–': [1473], 'Fenton': [1479], 'I,': [1480, 1856], 'Stenson': [1481], 'PD,': [1482], 'Abeysinghe': [1483], 'database:': [1493], 'biomedical': [1495], 'research': [1498], 'resource.': [1499], '45–': [1503], '51.': [1504], 'Laskowski': [1505], 'RA,': [1506], 'Macarthur': [1507], 'MW,': [1508], 'Moss': [1509], 'DS,': [1510], 'Thornton': [1511], 'JM.': [1512], 'PROCHECK:': [1514], 'program': [1516], 'stereochemical': [1520], 'structures.': [1524], 'Appl': [1526], 'Crystallogr': [1527], '26:': [1528], '283–': [1529], '291.': [1530], 'Lukatela': [1531], 'Krauss': [1533], 'Theis': [1535], 'Selmer': [1537], 'Gieselmann': [1539, 1930], 'von': [1541, 1649, 1927], 'Figura': [1542, 1928], 'Saenger': [1544], 'W.': [1545, 1589], 'arylsulfatase': [1551], 'A:': [1552], 'aldehyde': [1554], 'metal': [1558], 'ion': [1559], 'site': [1563], 'suggest': [1564], 'novel': [1566], 'mechanism': [1567, 2053], 'sulphate': [1569], 'ester': [1570], 'hydrolysis.': [1571], 'Biochemistry': [1572], '37:': [1573], '3654–': [1574], '3664.': [1575], 'Mather': [1576], 'Oganessyan': [1578], 'Hof': [1580], 'Huber': [1582], 'Foundling': [1584], 'Esmon': [1586], 'Bode': [1588], '1996.': [1590], '2.8': [1592], 'Å': [1593, 1778], 'Gla-domainless': [1597], 'activated': [1598], 'EMBO': [1601], '6822–': [1604], '6831.': [1605], 'Melsa': [1606], 'JL,': [1607], 'Cohn': [1608], 'DL.': [1609], '1978.': [1610], 'Decision': [1611], 'theory.': [1614], 'New': [1615, 1959], 'York:': [1616, 1960], 'McGraw-Hill.': [1617, 1961], 'p': [1618, 1962], '231–': [1619], '237.': [1620], 'Press': [1621], 'WH,': [1622], 'Flannery': [1623], 'BP,': [1624], 'Teukolsky': [1625], 'SA,': [1626], 'Vetterling': [1627], 'WT.': [1628], '1988.': [1629], 'Numerical': [1630], 'recipes': [1631], 'art': [1635], 'scientific': [1637], 'computing.': [1638], 'Cambridge:': [1639], 'Cambridge': [1640], 'Press.': [1642], 'Saarela': [1643], 'Laine': [1645], 'Oinonen': [1647], 'Schantz': [1650], 'Jalanko': [1652], 'Rouvinen': [1654], 'Peltonen': [1656], 'pathogenesis': [1660], 'disease:': [1663], 'aspartylglucosaminuria': [1667], '983–': [1673], '995.': [1674], 'Saraiva': [1675, 1729], 'MJ.': [1676], 'Transthyretin': [1678, 1734], 'hyperthyroxinemia': [1681], 'amyloid': [1683], '17:': [1687, 2025], '493–': [1688], '503.': [1689], 'Schreuder': [1690], 'HA,': [1691], 'de': [1692], 'Boer': [1693], 'Dijkema': [1695], 'Mulders': [1697], 'Theunissen': [1699], 'HJM,': [1700], 'Grootenhuis': [1701], 'PDJ,': [1702], 'Hol': [1703], 'WGJ.': [1704], 'intact': [1707], 'cleaved': [1709], 'complex': [1713], 'model': [1716], 'serpin-proteinase': [1718], 'interactions.': [1719], '1:': [1722], '48–': [1723], '54.': [1724], 'Sebastiao': [1725], 'MP,': [1726], 'Lamzin': [1727], 'MJ,': [1730], 'Damas': [1731], 'AM.': [1732], 'key': [1738], 'factor': [1739], 'amyloidogenesis:': [1741], 'atomic': [1745], '306:': [1750], '733–': [1751], '744.': [1752], 'Skinner': [1753], 'Chang': [1755], 'WS,': [1756], 'Jin': [1757], 'Pei': [1759], 'X,': [1760], 'Huntington': [1761], 'Abrahams': [1763], 'Carrell': [1765, 1791], 'RW,': [1766], 'Lomas': [1767], 'Implications': [1770], 'therapy': [1774], '2.9': [1777], 'binary-complexed': [1781], 'antithrombin.': [1782], '283:': [1786], '9–': [1787], '14.': [1788], 'Stein': [1789], 'PE,': [1790], 'RW.': [1792], '1995.': [1793, 1881], 'What': [1794], 'do': [1795], 'dysfunctional': [1796], 'serpins': [1797], 'tell': [1798], 'us': [1799], 'about': [1800], 'mobility': [1802], 'disease?': [1804], '2:': [1807], '96–': [1808], '113.': [1809], 'Sukegawa': [1810], 'Nakamura': [1812], 'Kato': [1814], 'Tomatsu': [1816], 'Montaño': [1818], 'AM,': [1819], 'Fukao': [1820], 'Toietta': [1822], 'Tortora': [1824], 'Orii': [1826], 'Kondo': [1828], 'Biochemical': [1831], 'missense': [1836, 2040], 'N-acetylgalactosamine-6-sulfate': [1839], 'sulfatase': [1840], 'causing': [1841], 'mucopolysaccharidosis': [1842], 'IVA': [1843], 'phenotypes.': [1844], '1283–': [1849], '1290.': [1850], 'Sunyaev': [1851], 'Ramensky': [1853], 'Koch': [1855], 'Lathe': [1857], 'W,': [1858], 'Kondrashov': [1859], 'AS,': [1860], 'Bork': [1861], 'P.': [1862, 2080], 'Prediction': [1864, 1904], 'deleterious': [1866], 'alleles.': [1868], '591–': [1873], '597.': [1874], 'PJ,': [1876, 2029], 'Qu': [1877], 'BH,': [1878], 'PL.': [1880], 'Defective': [1882], 'Trends': [1891], 'Biochem': [1892], 'Sci': [1893], '20:': [1894], '456–': [1895], '459.': [1896], 'Topham': [1897], 'CM,': [1898], 'Srinivasan': [1899], 'Blundell': [1901], 'TL.': [1902], 'mutants': [1910], 'based': [1911], 'environment-dependent': [1915], 'propensity': [1920], 'tables.': [1921], '7–': [1925], '21.': [1926], 'Jaeken': [1932], 'Metachromatic': [1935], 'leukodystrophy.': [1936], 'Chapter': [1937], '148.': [1938], 'In:': [1939], 'CR': [1940], 'Scriver,': [1941], 'AL': [1942], 'Beaudet,': [1943], 'WS': [1944], 'Sly,': [1945], 'D': [1946], 'Valle,': [1947], 'editors.': [1948], 'metabolic': [1950], 'bases': [1953], 'disease,': [1956], '8th': [1957], 'ed.': [1958], '3695–': [1963], '3724.': [1964], 'WHAT': [1968], 'IF:': [1969], 'modeling': [1972], 'drug': [1974], 'design': [1975], 'program.': [1976], 'Graph': [1979], '52–': [1981], '56.': [1982], 'Wacey': [1983], 'AI,': [1984], 'Liney': [1987], 'Hovig': [1989], 'Disentangling': [1994], 'perturbational': [1996], 'DNA-binding': [2004], 'p53.': [2007], '104:': [2010], '15–': [2011], '22.': [2012], 'Wang': [2013], 'Moult': [2015], 'SNPs,': [2018], '263–': [2026], '270.': [2027], 'Waters': [2028], 'Parniak': [2030], 'MA,': [2031], 'Akerman': [2032], 'BR,': [2033], 'Scriver': [2034], 'CR.': [2035], 'Characterization': [2037], 'phenylketonuria': [2039], 'substitutions,': [2041], 'distant': [2042], 'site,': [2048], 'illustrates': [2049], 'paradigm': [2051], 'potential': [2055], 'modulation': [2056], 'phenotype.': [2058], '69:': [2062], '101–': [2063], '110.': [2064], 'Weiner': [2065, 2079], 'SJ,': [2066], 'Kollman': [2067], 'PA,': [2068], 'Case': [2069], 'DA,': [2070], 'Singh': [2071], 'UC,': [2072], 'Ghio': [2073], 'Alagona': [2075], 'Profeta': [2077], '1984.': [2081], 'new': [2083], 'force-field': [2084], 'mechanical': [2087], 'simulation': [2088], 'nucleic': [2090], 'acids': [2091], 'Soc': [2097], '106:': [2098], '765–': [2099], '784.': [2100], 'Citing': [2101], 'Literature': [2102], 'Volume20,': [2103], 'Issue2August': [2104], '2002Pages': [2105], 'ReferencesRelatedInformation': [2107]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2030140659', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-08-14T01:56:02.724400', 'created_date': '2016-06-24'}