Title: Histochemistry of the 3β-hydroxysteroid, 17β-hydroxysteroid and 3α-hydroxysteroid dehydrogenases in human salivary glands
Abstract: Human parotid and submandibular glands showed no 3α-hydroxysteroid dehydro-genase (3α-HSD) activity. The 3β-hydroxysteroid dehydrogenase (3β-HSD) and the 17β-hydroxysteroid dehydrogenase (17β-HSD) appeared intensely reactive in the duct epithelia of the male and female glands and weakly reactive in the acinar cells of the female ones. The failure to demonstrate 3α-HSD activity indicates that in-vivo androgen activation, if present at all, is not so marked as in target organs. The different distribution of the 3β-HSD and 17β-HSD in the two sexes can be related not only to the oxidation of androgens but also to the metabolism of the female hormones. Glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) do not seem to be specifically influenced by the sex hormones as their pattern of distribution showed no sex differences.
Publication Year: 1982
Publication Date: 1982-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 14
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