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'https://openalex.org/W1784997902'], 'abstract_inverted_index': {'<h3>Background/Aims</h3>': [0], 'The': [1], 'lack': [2], 'of': [3, 17, 67, 82, 98, 120, 124, 132, 141, 154, 165, 186, 195], 'small': [4], 'animal': [5], 'models': [6, 34], 'supporting': [7], 'chronic': [8, 173], 'hepatitis': [9], 'B': [10], 'virus': [11], '(HBV)': [12], 'infection': [13], 'impedes': [14], 'the': [15, 21, 46, 96, 107, 114, 121, 125, 142, 187], 'assessment': [16], 'anti-viral': [18], 'drugs': [19], 'in': [20, 51, 101, 106, 113, 129, 157, 176, 182], 'whole': [22], 'animal.': [23], 'Although': [24], 'transgenic': [25], 'mice': [26, 57, 78], 'have': [27], 'been': [28], 'used': [29], 'for': [30, 72, 86, 135], 'this': [31, 158], 'purpose,': [32], 'these': [33], 'are': [35], 'clearly': [36], 'different': [37], 'from': [38, 45], 'natural': [39, 102], 'infection,': [40, 103], 'because': [41, 118], 'HBV': [42, 48, 68, 73, 116, 133, 147, 156, 169, 188, 197], 'is': [43], 'produced': [44, 105], 'integrated': [47], 'sequence': [49], 'harbored': [50], 'all': [52], 'hepatocytes.': [53], '<h3>Methods</h3>': [54], 'Balb/cA': [55], 'nude': [56], 'were': [58], 'hydrodynamically': [59], 'injected': [60, 77], 'with': [61], 'a': [62, 166, 193], 'plasmid': [63, 167], 'having': [64], '1.5-fold': [65], 'over-length': [66], 'DNA': [69, 94, 127, 148, 170], 'and': [70, 84, 109], 'analyzed': [71], 'replication.': [74], '<h3>Results</h3>': [75], 'Hydrodynamically': [76], 'showed': [79], 'substantial': [80], 'levels': [81], 'antigenemia': [83], 'viremia': [85], 'more': [87], 'than': [88, 137], '1': [89], 'year.': [90], 'Covalently': [91], 'closed': [92], 'circular': [93], '(cccDNA),': [95], 'template': [97], 'viral': [99, 174], 'replication': [100, 175], 'was': [104, 110, 151], 'livers': [108], 'critically': [111], 'involved': [112], 'long-term': [115], 'production,': [117], 'disruption': [119], '<i>pol</i>': [122], 'gene': [123, 144, 163], 'inoculated': [126], 'resulted': [128], 'transient': [130], 'expression': [131], 'genes': [134], 'less': [136], '2': [138], 'months.': [139], 'Administration': [140], 'IFNα': [143], 'transiently': [145], 'suppressed': [146], 'replication,': [149], 'but': [150], 'not': [152], 'capable': [153], 'eliminating': [155], 'model.': [159], '<h3>Conclusions</h3>': [160], 'In': [161], 'vivo': [162], 'transfer': [164], 'encoding': [168], 'can': [171], 'establish': [172], 'mice,': [177], 'which': [178], 'involves,': [179], 'at': [180], 'least': [181], 'part,': [183], 'new': [184], 'synthesis': [185], 'cccDNA': [189], 'episome,': [190], 'thus': [191], 'recapitulating': [192], 'part': [194], 'human': [196], 'infection.': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2029974800', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}], 'updated_date': '2024-08-15T06:15:34.711191', 'created_date': '2016-06-24'}