Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2029950981', 'doi': 'https://doi.org/10.1210/mend.12.9.0172', 'title': 'Inhibition by Insulin of Glucocorticoid-Induced Gene Transcription: Involvement of the Ligand-Binding Domain of the Glucocorticoid Receptor and Independence from the Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Pathways', 'display_name': 'Inhibition by Insulin of Glucocorticoid-Induced Gene Transcription: Involvement of the Ligand-Binding Domain of the Glucocorticoid Receptor and Independence from the Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Pathways', 'publication_year': 1998, 'publication_date': '1998-09-01', 'ids': {'openalex': 'https://openalex.org/W2029950981', 'doi': 'https://doi.org/10.1210/mend.12.9.0172', 'mag': '2029950981', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9731703'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/mend.12.9.0172', 'pdf_url': 'https://academic.oup.com/mend/article-pdf/12/9/1343/10713852/mend1343.pdf', 'source': {'id': 'https://openalex.org/S57449756', 'display_name': 'Molecular Endocrinology', 'issn_l': '0888-8809', 'issn': ['0888-8809', '1944-9917'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/mend/article-pdf/12/9/1343/10713852/mend1343.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054437186', 'display_name': 'Christophe E. Pierreux', 'orcid': 'https://orcid.org/0000-0002-9647-2816'}, 'institutions': [{'id': 'https://openalex.org/I4210114657', 'display_name': 'de Duve Institute', 'ror': 'https://ror.org/022em3k58', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114657']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Christophe E. Pierreux', 'raw_affiliation_strings': ['Hormone and Metabolic Research Unit (C.E.P., G.G.R., F.P.L.) Louvain University Medical School Christian de Duve Institute of Cellular Pathology (ICP) B-1200 Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Hormone and Metabolic Research Unit (C.E.P., G.G.R., F.P.L.) Louvain University Medical School Christian de Duve Institute of Cellular Pathology (ICP) B-1200 Brussels, Belgium', 'institution_ids': ['https://openalex.org/I4210114657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041942475', 'display_name': 'Birgitte Ursø', 'orcid': None}, 'institutions': [], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Birgitte Ursø', 'raw_affiliation_strings': ['Department of Molecular Signaling (B.U., P.D.M.) Hagedorn Research Institute DK-2820 Gentofte, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Signaling (B.U., P.D.M.) Hagedorn Research Institute DK-2820 Gentofte, Denmark', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015494879', 'display_name': 'Pierre De Meyts', 'orcid': 'https://orcid.org/0000-0001-6214-0824'}, 'institutions': [], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Pierre De Meyts', 'raw_affiliation_strings': ['Department of Molecular Signaling (B.U., P.D.M.) Hagedorn Research Institute DK-2820 Gentofte, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Signaling (B.U., P.D.M.) Hagedorn Research Institute DK-2820 Gentofte, Denmark', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083771400', 'display_name': 'Guy Rousseau', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114657', 'display_name': 'de Duve Institute', 'ror': 'https://ror.org/022em3k58', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114657']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Guy G. Rousseau', 'raw_affiliation_strings': ['Hormone and Metabolic Research Unit (C.E.P., G.G.R., F.P.L.) Louvain University Medical School Christian de Duve Institute of Cellular Pathology (ICP) B-1200 Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Hormone and Metabolic Research Unit (C.E.P., G.G.R., F.P.L.) Louvain University Medical School Christian de Duve Institute of Cellular Pathology (ICP) B-1200 Brussels, Belgium', 'institution_ids': ['https://openalex.org/I4210114657']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040884856', 'display_name': 'Frédéric P. Lemaigre', 'orcid': 'https://orcid.org/0000-0002-3609-434X'}, 'institutions': [{'id': 'https://openalex.org/I4210114657', 'display_name': 'de Duve Institute', 'ror': 'https://ror.org/022em3k58', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114657']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Frédéric P. Lemaigre', 'raw_affiliation_strings': ['Hormone and Metabolic Research Unit (C.E.P., G.G.R., F.P.L.) Louvain University Medical School Christian de Duve Institute of Cellular Pathology (ICP) B-1200 Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Hormone and Metabolic Research Unit (C.E.P., G.G.R., F.P.L.) Louvain University Medical School Christian de Duve Institute of Cellular Pathology (ICP) B-1200 Brussels, Belgium', 'institution_ids': ['https://openalex.org/I4210114657']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.793, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.73103, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '12', 'issue': '9', 'first_page': '1343', 'last_page': '1354'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Mechanisms of Estrogen Receptor Signaling', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Mechanisms of Estrogen Receptor Signaling', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11503', 'display_name': 'Role of STAT3 in Cancer Inflammation and Immunity', 'score': 0.9831, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9827, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hormone-response-element', 'display_name': 'Hormone response element', 'score': 0.53512454}, {'id': 'https://openalex.org/keywords/glucocorticoids', 'display_name': 'Glucocorticoids', 'score': 0.518424}, {'id': 'https://openalex.org/keywords/transcriptional-control', 'display_name': 'transcriptional control', 'score': 0.511935}, {'id': 'https://openalex.org/keywords/grb10', 'display_name': 'GRB10', 'score': 0.42794085}, {'id': 'https://openalex.org/keywords/insulin-receptor-substrate', 'display_name': 'Insulin receptor substrate', 'score': 0.4268502}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6905699}, {'id': 'https://openalex.org/C59493245', 'wikidata': 'https://www.wikidata.org/wiki/Q14877410', 'display_name': 'Glucocorticoid receptor', 'level': 3, 'score': 0.60447073}, {'id': 'https://openalex.org/C112446052', 'wikidata': 'https://www.wikidata.org/wiki/Q422579', 'display_name': 'Insulin receptor', 'level': 4, 'score': 0.5523855}, {'id': 'https://openalex.org/C51445715', 'wikidata': 'https://www.wikidata.org/wiki/Q410477', 'display_name': 'Hormone response element', 'level': 5, 'score': 0.53512454}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.48947728}, {'id': 'https://openalex.org/C2780841215', 'wikidata': 'https://www.wikidata.org/wiki/Q422549', 'display_name': 'Glucocorticoid', 'level': 2, 'score': 0.4733874}, {'id': 'https://openalex.org/C82183700', 'wikidata': 'https://www.wikidata.org/wiki/Q14914347', 'display_name': 'GRB10', 'level': 5, 'score': 0.42794085}, {'id': 'https://openalex.org/C185967709', 'wikidata': 'https://www.wikidata.org/wiki/Q101433828', 'display_name': 'Insulin receptor substrate', 'level': 5, 'score': 0.4268502}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3288914}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.30413815}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.2333965}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19692498}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.1124551}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.108143866}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.1022926}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.082837164}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D022762', 'descriptor_name': 'CCAAT-Enhancer-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017871', 'descriptor_name': 'Calcium-Calmodulin-Dependent Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011965', 'descriptor_name': 'Receptors, Glucocorticoid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017871', 'descriptor_name': 'Calcium-Calmodulin-Dependent Protein Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D017871', 'descriptor_name': 'Calcium-Calmodulin-Dependent Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051541', 'descriptor_name': 'Hepatocyte Nuclear Factor 3-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051542', 'descriptor_name': 'Hepatocyte Nuclear Factor 3-beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051543', 'descriptor_name': 'Hepatocyte Nuclear Factor 3-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051559', 'descriptor_name': 'Hepatocyte Nuclear Factor 6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051839', 'descriptor_name': 'NFI Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025481', 'descriptor_name': 'Phosphofructokinase-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011965', 'descriptor_name': 'Receptors, Glucocorticoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051840', 'descriptor_name': 'Y-Box-Binding Protein 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/mend.12.9.0172', 'pdf_url': 'https://academic.oup.com/mend/article-pdf/12/9/1343/10713852/mend1343.pdf', 'source': {'id': 'https://openalex.org/S57449756', 'display_name': 'Molecular Endocrinology', 'issn_l': '0888-8809', 'issn': ['0888-8809', '1944-9917'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9731703', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/mend.12.9.0172', 'pdf_url': 'https://academic.oup.com/mend/article-pdf/12/9/1343/10713852/mend1343.pdf', 'source': {'id': 'https://openalex.org/S57449756', 'display_name': 'Molecular Endocrinology', 'issn_l': '0888-8809', 'issn': ['0888-8809', '1944-9917'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1529396499', 'https://openalex.org/W1586323548', 'https://openalex.org/W1590900604', 'https://openalex.org/W1602103287', 'https://openalex.org/W1613040252', 'https://openalex.org/W1650110890', 'https://openalex.org/W1710576323', 'https://openalex.org/W1784060230', 'https://openalex.org/W1803816860', 'https://openalex.org/W1818313483', 'https://openalex.org/W1871945847', 'https://openalex.org/W1944329969', 'https://openalex.org/W1944789111', 'https://openalex.org/W1969442037', 'https://openalex.org/W1969468354', 'https://openalex.org/W1971915141', 'https://openalex.org/W1977176665', 'https://openalex.org/W1977487234', 'https://openalex.org/W1981067651', 'https://openalex.org/W1983114585', 'https://openalex.org/W2005270847', 'https://openalex.org/W2006171246', 'https://openalex.org/W2013922414', 'https://openalex.org/W2020970433', 'https://openalex.org/W2024918809', 'https://openalex.org/W2024942502', 'https://openalex.org/W2025457180', 'https://openalex.org/W2035936653', 'https://openalex.org/W2036871521', 'https://openalex.org/W2038072610', 'https://openalex.org/W2040495689', 'https://openalex.org/W2044951153', 'https://openalex.org/W2053083708', 'https://openalex.org/W2057486586', 'https://openalex.org/W2058390591', 'https://openalex.org/W2058899879', 'https://openalex.org/W2059911808', 'https://openalex.org/W2061463166', 'https://openalex.org/W2068733538', 'https://openalex.org/W2070669901', 'https://openalex.org/W2074049733', 'https://openalex.org/W2075339282', 'https://openalex.org/W2087750382', 'https://openalex.org/W2088583666', 'https://openalex.org/W2092281396', 'https://openalex.org/W2107749241', 'https://openalex.org/W2113006753', 'https://openalex.org/W2121666098', 'https://openalex.org/W2133208346', 'https://openalex.org/W2165218504', 'https://openalex.org/W2168006710', 'https://openalex.org/W2306751271', 'https://openalex.org/W2335447520', 'https://openalex.org/W2335683301', 'https://openalex.org/W2413332307', 'https://openalex.org/W4231854580', 'https://openalex.org/W4241396370'], 'related_works': ['https://openalex.org/W2169761708', 'https://openalex.org/W2160433188', 'https://openalex.org/W2116713371', 'https://openalex.org/W2046124930', 'https://openalex.org/W2044714476', 'https://openalex.org/W1992002046', 'https://openalex.org/W1982573599', 'https://openalex.org/W1981179996', 'https://openalex.org/W1969744026', 'https://openalex.org/W1967235396'], 'abstract_inverted_index': {'Insulin': [0], 'can': [1], 'inhibit': [2], 'the': [3, 10, 27, 31, 40, 49, 53, 68, 75, 82, 87, 115, 135, 149, 157, 162, 166, 170, 173, 180, 195, 204], 'stimulatory': [4], 'effect': [5, 137], 'of': [6, 12, 30, 42, 52, 114, 127, 138, 161, 169, 179], 'glucocorticoid': [7, 69, 88, 122, 163], 'hormones': [8], 'on': [9, 194], 'transcription': [11, 29, 109], 'genes': [13], 'coding': [14, 33], 'for': [15, 34], 'enzymes': [16], 'involved': [17, 133, 176], 'in': [18, 56, 74, 134, 148, 206], 'glucose': [19], 'metabolism.': [20], 'We': [21, 59, 140], 'reported': [22], 'earlier': [23], 'that': [24, 61, 81, 118, 125, 154, 191], 'insulin': [25, 65, 145, 155, 192], 'inhibits': [26], 'glucocorticoid-stimulated': [28], 'gene': [32, 55, 197], 'liver': [35], '6-phosphofructo-2-kinase': [36], '(PFK-2).': [37], 'To': [38], 'elucidate': [39], 'mechanism': [41], 'these': [43, 119, 188], 'hormonal': [44], 'effects,': [45], 'we': [46, 152], 'have': [47], 'studied': [48], 'regulatory': [50], 'regions': [51], 'PFK-2': [54, 196], 'transfection': [57], 'experiments.': [58], 'found': [60], 'both': [62], 'glucocorticoids': [63], 'and': [64, 98, 182, 201], 'act': [66], 'via': [67, 198], 'response': [70, 146], 'unit': [71], '(GRU)': [72], 'located': [73], 'first': [76], 'intron.': [77], 'Footprinting': [78], 'experiments': [79], 'showed': [80, 153], 'GRU': [83, 116], 'binds': [84], 'not': [85, 142], 'only': [86], 'receptor': [89], '(GR),': [90], 'but': [91, 124, 151], 'also': [92], 'ubiquitous': [93], '[nuclear': [94], 'factor': [95, 102], 'I': [96], '(NF-I)]': [97], 'liver-enriched': [99], '[hepatocyte': [100], 'nuclear': [101], '(HNF)-3,': [103], 'HNF-6,': [104], 'CAAT/enhancer': [105], 'binding': [106], 'protein': [107, 184], '(C/EBP)]': [108], 'factors.': [110], 'Site-directed': [111], 'mutational': [112], 'analysis': [113], 'revealed': [117], 'factors': [120], 'modulate': [121], 'action': [123], 'none': [126], 'them': [128], 'seems': [129], 'to': [130], 'be': [131], 'individually': [132], 'inhibitory': [136], 'insulin.': [139], 'did': [141], 'find': [143], 'an': [144], 'element': [147], 'GRU,': [150], 'targets': [156, 202], 'GR.': [158, 171], 'Insulin-induced': [159], 'inhibition': [160], 'stimulation': [164], 'required': [165], 'ligand-binding': [167, 208], 'domain': [168, 209], 'Finally,': [172], 'insulin-signaling': [174], 'cascade': [175], 'was': [177], 'independent': [178], 'phosphatidylinositol-3-kinase': [181], 'mitogen-activated': [183], 'kinase': [185], 'pathways.': [186], 'Together,': [187], 'results': [189], 'suggest': [190], 'acts': [193], 'another': [199], 'pathway': [200], 'either': [203], 'GR': [205], 'its': [207], 'or': [210], 'a': [211], 'cofactor': [212], 'interacting': [213], 'with': [214], 'this': [215], 'domain.': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2029950981', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-08-31T18:17:57.364185', 'created_date': '2016-06-24'}