Title: II. The pharmacology of pseudaconitine and japaconitine considered relation to that of aconitine
Abstract:In a previous paper on the Pharmacology of Aconitine and some of its principal derivatives (‘Phil. Trans.,’ B, 1898, vol. 190, p. 239), we have given an account of the physiological action of this, th...In a previous paper on the Pharmacology of Aconitine and some of its principal derivatives (‘Phil. Trans.,’ B, 1898, vol. 190, p. 239), we have given an account of the physiological action of this, the highly toxic alkaloid of Monkshood (Napellus), and of its principal derivatives, and we have also discussed the ascertained physiological effects of these substances in relation to their chemical constitution. The results of this investigation have proved to he of much practical importance in connection with the pharmaceutical and medical employment of aconite, especially in demonstrating the partial antagonism of aconitine to benzaconine, and in a greater degree of aconine, both of which derivatives accompany the parent alkaloid in the plant, and in the pharmaceutical preparations made from it. Although it seems likely that these separate alkaloids, and especially aconine, may be useful as therapeutic agents, it is now clear that for the purpose for which aconite is employed, the pure alkaloid, aconitine, should be used in the place of the indefinite mixture of physiologically antagonistic alkaloids contained in pharmaceutical preparations made from the plant. In a series of papers communicated to the Chemical Society and published in the ‘Journal of the Chemical Society’ (1891-1900), one of us, in conjunction with his pupils, has described the chemical properties of the toxic alkaloid contained in two other species of the plant, viz., Aconitum ferox or Indian or Nepal aconite, and Aconitum Fischeror Japanese aconite. The medicinal employment of these potent drugs has been very restricted in the absence of any definite knowledge as to the nature of their constituents and the physiological action to which they give rise.Read More
Publication Year: 1903
Publication Date: 1903-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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