Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2029645694', 'doi': 'https://doi.org/10.7326/0003-4819-158-2-201301150-00019', 'title': 'Escitalopram for the Prevention of Peginterferon-α2a–Associated Depression', 'display_name': 'Escitalopram for the Prevention of Peginterferon-α2a–Associated Depression', 'publication_year': 2013, 'publication_date': '2013-01-15', 'ids': {'openalex': 'https://openalex.org/W2029645694', 'doi': 'https://doi.org/10.7326/0003-4819-158-2-201301150-00019', 'mag': '2029645694', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23318323'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-158-2-201301150-00019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080824682', 'display_name': 'Gijs W.D. Landman', 'orcid': 'https://orcid.org/0000-0002-6852-6450'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Gijs W.D. Landman', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5080824682'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.243902, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 72, 'max': 76}, 'biblio': {'volume': '158', 'issue': '2', 'first_page': '139', 'last_page': '139'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13283', 'display_name': 'Network Analysis of Psychopathology and Mental Disorders', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/3205', 'display_name': 'Experimental and Cognitive Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13283', 'display_name': 'Network Analysis of Psychopathology and Mental Disorders', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/3205', 'display_name': 'Experimental and Cognitive Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}, {'id': 'https://openalex.org/T11337', 'display_name': 'Neuroimmune Interaction in Psychiatric Disorders', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11071', 'display_name': 'Molecular Mechanisms of Depression Treatment Strategies', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/escitalopram', 'display_name': 'Escitalopram', 'score': 0.9166603}, {'id': 'https://openalex.org/keywords/antidepressant-treatment', 'display_name': 'Antidepressant Treatment', 'score': 0.564827}, {'id': 'https://openalex.org/keywords/depression', 'display_name': 'Depression', 'score': 0.517707}, {'id': 'https://openalex.org/keywords/antidepressants', 'display_name': 'Antidepressants', 'score': 0.504852}, {'id': 'https://openalex.org/keywords/depression-symptoms', 'display_name': 'Depression Symptoms', 'score': 0.502146}, {'id': 'https://openalex.org/keywords/treatment-resistant-depression', 'display_name': 'Treatment-Resistant Depression', 'score': 0.502004}], 'concepts': [{'id': 'https://openalex.org/C2779583969', 'wikidata': 'https://www.wikidata.org/wiki/Q423757', 'display_name': 'Escitalopram', 'level': 4, 'score': 0.9166603}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.76769614}, {'id': 'https://openalex.org/C2776867660', 'wikidata': 'https://www.wikidata.org/wiki/Q1814941', 'display_name': 'Depression (economics)', 'level': 2, 'score': 0.7040332}, {'id': 'https://openalex.org/C2775972397', 'wikidata': 'https://www.wikidata.org/wiki/Q3577449', 'display_name': 'Montgomery–Åsberg Depression Rating Scale', 'level': 4, 'score': 0.6872146}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6327239}, {'id': 'https://openalex.org/C61511704', 'wikidata': 'https://www.wikidata.org/wiki/Q1671857', 'display_name': 'Incidence (geometry)', 'level': 2, 'score': 0.4825634}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.46954948}, {'id': 'https://openalex.org/C2780051608', 'wikidata': 'https://www.wikidata.org/wiki/Q42844', 'display_name': 'Major depressive disorder', 'level': 3, 'score': 0.4133421}, {'id': 'https://openalex.org/C558461103', 'wikidata': 'https://www.wikidata.org/wiki/Q154430', 'display_name': 'Anxiety', 'level': 2, 'score': 0.27016422}, {'id': 'https://openalex.org/C2779177272', 'wikidata': 'https://www.wikidata.org/wiki/Q76560', 'display_name': 'Antidepressant', 'level': 3, 'score': 0.1425223}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2779144063', 'wikidata': 'https://www.wikidata.org/wiki/Q338924', 'display_name': 'Amygdala', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C139719470', 'wikidata': 'https://www.wikidata.org/wiki/Q39680', 'display_name': 'Macroeconomics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018687', 'descriptor_name': 'Antidepressive Agents, Second-Generation', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D015283', 'descriptor_name': 'Citalopram', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D003863', 'descriptor_name': 'Depression', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D019698', 'descriptor_name': 'Hepatitis C, Chronic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D018687', 'descriptor_name': 'Antidepressive Agents, Second-Generation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015283', 'descriptor_name': 'Citalopram', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003863', 'descriptor_name': 'Depression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019698', 'descriptor_name': 'Hepatitis C, Chronic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-158-2-201301150-00019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23318323', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.45}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 4, 'referenced_works': ['https://openalex.org/W1979534890', 'https://openalex.org/W1986838837', 'https://openalex.org/W2015677071', 'https://openalex.org/W2065975770'], 'related_works': ['https://openalex.org/W3000424508', 'https://openalex.org/W2982571585', 'https://openalex.org/W2279122780', 'https://openalex.org/W2263559144', 'https://openalex.org/W2124182596', 'https://openalex.org/W2049340604', 'https://openalex.org/W2025139876', 'https://openalex.org/W2020052606', 'https://openalex.org/W2017552008', 'https://openalex.org/W1964794208'], 'abstract_inverted_index': {'Letters15': [0], 'January': [1, 447, 460, 465], '2013Escitalopram': [2], 'for': [3, 22, 121, 154, 282, 365, 403], 'the': [4, 20, 58, 99, 110, 128, 135, 155, 222, 274, 283, 366, 407, 437], 'Prevention': [5, 284, 367], 'of': [6, 60, 75, 104, 119, 130, 157, 187, 241, 285, 368, 395, 401, 413, 417, 453, 475], 'Peginterferon-α2a–Associated': [7, 286, 369], 'DepressionGijs': [8], 'W.D.': [9, 12, 265], 'Landman,': [10, 13, 266], 'MDGijs': [11], 'MDFrom': [14], 'Diabetes': [15, 269], 'Centre,': [16, 270], 'Isala': [17, 271], 'Clinics,': [18, 272], 'Zwolle,': [19, 273], 'Netherlands.Search': [21], 'more': [23], 'papers': [24], 'by': [25, 406, 472], 'this': [26], 'authorAuthor,': [27], 'Article,': [28, 260], 'and': [29, 43, 95, 218, 261, 361, 380, 389, 410, 415, 433, 442], 'Disclosure': [30, 262], 'Informationhttps://doi.org/10.7326/0003-4819-158-2-201301150-00019': [31], 'SectionsAboutFull': [32], 'TextPDF': [33], 'ToolsAdd': [34], 'to': [35, 62, 195, 436], 'favoritesDownload': [36], 'CitationsTrack': [37], 'CitationsPermissions': [38], 'ShareFacebookTwitterLinkedInRedditEmail': [39], 'TO': [40], 'THE': [41], 'EDITOR:Schaefer': [42], 'colleagues': [44], '(1)': [45], 'performed': [46], 'an': [47], 'industry-sponsored': [48], 'trial': [49], 'investigating': [50], 'whether': [51], 'preemptive': [52], 'antidepressive': [53], 'medication': [54], 'could': [55], 'potentially': [56], 'decrease': [57], 'incidence': [59, 103], 'moderate': [61, 94, 122, 217], 'severe': [63, 96, 219], 'depression': [64, 97, 159, 220, 224], 'in': [65, 92, 98, 160, 243, 248, 288, 386, 425], 'patients': [66, 164], 'with': [67, 81, 116], 'hepatitis': [68, 161], 'C': [69, 162, 290, 456], 'virus': [70], 'infection': [71], 'without': [72, 165], 'a': [73, 82, 89, 117, 131, 169], 'history': [74], 'depressive': [76, 105, 132, 246], 'symptoms': [77], 'who': [78], 'are': [79], 'treated': [80], 'regimen': [83], 'containing': [84], 'pegylated': [85], 'interferon-α.': [86], 'They': [87], 'found': [88], 'significant': [90], 'reduction': [91], 'both': [93], 'escitalopram': [100, 242], 'group.': [101], 'The': [102], 'disorders': [106], 'was': [107], 'measured': [108], 'using': [109, 188, 221], 'Montgomery–Asberg': [111], 'Depression': [112, 287, 370], 'Rating': [113], 'Scale': [114], '(MADRS)': [115], 'cutoff': [118], '13': [120], 'depression.I': [123], 'have': [124], '2': [125], 'concerns': [126], 'about': [127], 'definition': [129], 'disorder.': [133], 'First,': [134], 'original': [136], 'study': [137], '...References1.': [138], 'Schaefer': [139, 298, 372], 'M,': [140, 181], 'Sarkar': [141, 301, 378], 'R,': [142], 'Knop': [143, 304], 'V,': [144], 'Effenberger': [145, 307], 'S,': [146], 'Friebe': [147, 310], 'A,': [148], 'Heinze': [149, 313], 'L,': [150], 'et': [151], 'al.': [152], 'Escitalopram': [153, 364], 'prevention': [156], 'peginterferon-α2a-associated': [158], 'virus-infected': [163], 'previous': [166], 'psychiatric': [167], 'disease:': [168], 'randomized': [170], 'trial.': [171], 'Ann': [172], 'Intern': [173], 'Med.': [174], '2012;157:94-103.': [175], '[PMID:': [176, 204, 232, 255], '22801672]': [177], 'LinkGoogle': [178], 'Scholar2.': [179], 'Zimmerman': [180], 'Posternak': [182], 'MA,': [183], 'Chelminski': [184], 'I.': [185], 'Implications': [186], 'different': [189], 'cut-offs': [190], 'on': [191], 'symptom': [192], 'severity': [193], 'scales': [194], 'define': [196], 'remission': [197], 'from': [198], 'depression.': [199], 'Int': [200, 251], 'Clin': [201, 252], 'Psychopharmacol.': [202, 253], '2004;19:215-20.': [203], '15201568]': [205], 'CrossrefMedlineGoogle': [206, 234, 257], 'Scholar3.': [207], 'Müller': [208], 'MJ,': [209], 'Himmerich': [210], 'H,': [211], 'Kienzle': [212], 'B,': [213], 'Szegedi': [214], 'A.': [215, 439], 'Differentiating': [216], 'Montgomery-Asberg': [223], 'rating': [225], 'scale': [226], '(MADRS).': [227], 'J': [228], 'Affect': [229], 'Disord.': [230], '2003;77:255-60.': [231], '14612225]': [233], 'Scholar4.': [235], 'Einarson': [236], 'TR.': [237], 'Evidence': [238], 'based': [239], 'review': [240], 'treating': [244], 'major': [245], 'disorder': [247], 'primary': [249, 387], 'care.': [250], '2004;19:305-10.': [254], '15289704]': [256], 'Scholar': [258], 'Author,': [259], 'InformationAuthors:': [263], 'Gijs': [264], 'MDAffiliations:': [267], 'From': [268], 'Netherlands.Disclosures:': [275], 'None': [276], 'disclosed.': [277], 'PreviousarticleNextarticle': [278], 'Advertisement': [279], 'FiguresReferencesRelatedDetailsSee': [280], 'AlsoEscitalopram': [281], 'Hepatitis': [289], 'Virus–Infected': [291], 'Patients': [292], 'Without': [293], 'Previous': [294], 'Psychiatric': [295], 'Disease': [296], 'Martin': [297, 371], ',': [299, 302, 305, 308, 311, 314, 317, 320, 323, 326, 329, 332, 335, 338, 341, 344, 348, 351, 354, 357, 360, 373, 376, 379], 'Rahul': [300], 'Viola': [303], 'Susanne': [306, 377], 'Astrid': [309], 'Loni': [312], 'Ulrich': [315], 'Spengler': [316], 'Thomas': [318, 345, 352, 362, 374], 'Schlaepfer': [319], 'Jens': [321], 'Reimer': [322], 'Peter': [324], 'Buggisch': [325], 'Johann': [327], 'Ockenga': [328], 'Ralph': [330], 'Link': [331], 'Michael': [333], 'Rentrop': [334], 'Hans': [336], 'Weidenbach': [337], 'Gwendolyn': [339], 'Fromm': [340], 'Klaus': [342], 'Lieb': [343], 'F.': [346], 'Baumert': [347], 'Andreas': [349], 'Heinz': [350], 'Discher': [353], 'Konrad': [355, 381], 'Neumann': [356, 382], 'Stefan': [358], 'Zeuzem': [359], 'Berg': [363, 375], 'Metrics': [383], 'Cited': [384], 'byChanges': [385], 'outcome': [388], 'sample': [390], 'size': [391], 'measures': [392], 'after': [393], 'initiation': [394], 'accrual': [396], 'among': [397, 420], 'trials': [398, 423], 'supporting': [399], 'approval': [400], 'drugs': [402], 'hematological': [404], 'malignancies': [405], 'US': [408], 'food': [409], 'drug': [411, 422], 'administrationAssessment': [412], 'frequency': [414], 'reporting': [416], 'design': [418], 'changes': [419], 'clinical': [421], 'published': [424], 'influential': [426], 'medical': [427], 'journalsTrust': [428], 'but': [429], 'Verify:': [430], 'Trial': [431], 'Registration': [432], 'Determining': [434], 'Fidelity': [435], 'ProtocolDeborah': [438], 'Zarin,': [440], 'MD': [441], 'Tony': [443], 'Tse,': [444], 'PhD': [445], '15': [446, 459, 464], '2013Volume': [448], '158,': [449], 'Issue': [450, 462], '2Page:': [451], '139-140KeywordsConflicts': [452], 'interestDepressionHepatitis': [454], 'AHepatitis': [455], 'virusInterferons': [457], 'ePublished:': [458], '2013': [461, 466, 471], 'Published:': [463], 'Copyright': [467], '&': [468], 'PermissionsCopyright': [469], '©': [470], 'American': [473], 'College': [474], 'Physicians.': [476], 'All': [477], 'Rights': [478], 'Reserved.PDF': [479], 'downloadLoading': [480], '...': [481]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2029645694', 'counts_by_year': [{'year': 2020, 'cited_by_count': 2}], 'updated_date': '2024-08-22T14:12:43.496149', 'created_date': '2016-06-24'}