Title: Analgesic effects of enkephalin analogs in rats
Abstract: The analgesic effects of intracerebroventricular injections of Met-enkelphalin and five of its analogs in a dose of 10 μg each were quantified with a hot plate test in rats. Two analogs showed analgesic effect. ⦜D-Ala2, Met5⊥-enkephalinamide and short-lasting analgesic effect. ⦜D-Ala2, Met5⊥-enkelphalinamide had a weak (DALA) had a striking and long-lasting analgesic effect. However, sulfation of tyrosine residue totally abolished the analgesic action of DALA. The analgesic effect of DALA was not affected by preinjection of its sulfated analog.
Publication Year: 1984
Publication Date: 1984-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 2
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