Publication Information

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4094, 4281, 4308, 4389, 4401, 4438, 4452, 4474], 'Orai1': [3, 108, 146, 156, 232, 302, 407, 445, 455, 531, 876, 917, 936, 1136, 1235, 1345, 1434, 1662, 1753, 1814, 1927, 1957, 1970, 2002, 2086, 2250, 3169, 3379, 3419, 3424, 3521, 3581, 3626, 3637, 3735, 3743, 4102, 4114, 4292, 4317, 4493], 'bearing': [4, 303, 877, 2289], 'the': [5, 10, 16, 67, 89, 96, 128, 131, 135, 154, 186, 192, 196, 202, 209, 213, 217, 235, 240, 254, 263, 269, 286, 296, 304, 309, 315, 366, 388, 395, 427, 430, 434, 453, 485, 491, 495, 501, 508, 512, 516, 534, 539, 553, 562, 568, 585, 595, 602, 635, 638, 646, 656, 662, 667, 866, 915, 998, 1118, 1132, 1138, 1143, 1250, 1284, 1301, 1307, 1335, 1412, 1415, 1418, 1431, 1439, 1445, 1660, 1667, 1671, 1740, 1751, 1922, 1926, 1931, 1946, 1961, 1975, 1979, 1989, 2083, 2119, 2126, 2130, 2142, 2145, 2151, 2160, 2171, 2178, 2188, 2207, 2220, 2256, 2290, 2302, 2307, 2310, 2323, 2340, 2347, 2461, 2528, 2550, 2556, 2581, 2778, 2789, 2994, 3172, 3327, 3369, 3388, 3413, 3416, 3484, 3488, 3493, 3509, 3574, 3586, 3606, 3609, 3614, 3634, 3646, 3669, 3690, 3707, 3741, 3757, 3762, 3769, 3777, 3782, 3802, 3860, 3912, 3938, 3942, 3954, 3964, 4015, 4030, 4044, 4048, 4067, 4092, 4100, 4112, 4133, 4279, 4296, 4306, 4316, 4327, 4335, 4339, 4346, 4360, 4367, 4374, 4392, 4423, 4436, 4439, 4447, 4457, 4466, 4472, 4475, 4483, 4491, 4502], 'R91W': [6, 155, 230, 305, 454, 529, 1432, 1661, 1752, 2152, 2291, 3376, 3587, 3610, 3742, 3881, 3920, 4016, 4095, 4311, 4467], 'mutation': [7, 68, 306, 367, 881, 1663, 1754, 2292, 3588, 4119, 4468], 'results': [8, 170, 307, 469, 1983], 'in': [9, 24, 78, 134, 171, 175, 195, 234, 295, 308, 323, 377, 433, 470, 474, 494, 533, 594, 634, 655, 719, 919, 941, 978, 1113, 1125, 1127, 1233, 1311, 1338, 1414, 1438, 1717, 1739, 1819, 2026, 2159, 2174, 2187, 2309, 2339, 2451, 2527, 2563, 2593, 2761, 2765, 2808, 2882, 2891, 2993, 3087, 3162, 3171, 3331, 3336, 3341, 3387, 3427, 3486, 3582, 3591, 3613, 3645, 3761, 3793, 3854, 3900, 3961, 3988, 4019, 4024, 4029, 4066, 4099, 4132, 4288, 4315, 4334, 4352, 4373, 4391, 4396], 'complete': [11, 310, 2635], 'abrogation': [12, 311], 'currents': [14, 178, 313, 477, 1547, 2158, 2465, 2768, 2890, 3086, 3181, 3343, 3386, 3852, 3885, 3960, 4032, 4078, 4325, 4400], 'through': [15, 314, 4326], 'store-operated': [17, 75, 316, 374, 603, 927, 992, 1309, 1714, 2767], 'Ca2+': [18, 20, 76, 292, 317, 319, 375, 591, 600, 604, 606, 928, 993, 1715, 1732, 1761, 2845, 4130], 'release-activated': [19, 318, 605, 614], '(CRAC)': [21, 320, 607], 'channels,': [22, 321, 1292], 'resulting': [23, 322, 654, 1980, 2186, 3426, 4297, 4440, 4496], 'a': [25, 85, 104, 140, 172, 324, 384, 403, 439, 471, 631, 845, 854, 870, 878, 1241, 1294, 1757, 1938, 1964, 1998, 2027, 2034, 2261, 2397, 2633, 2684, 2746, 2773, 2805, 2832, 2873, 3064, 3076, 3350, 3374, 3392, 3517, 3594, 3619, 3652, 3676, 3790, 3844, 3981, 4010, 4021, 4126, 4283, 4289, 4353, 4412], 'form': [26, 325, 856, 1288, 1420], 'hereditary': [28, 327, 855, 1419], 'severe': [29, 328, 617, 706], 'combined': [30, 329, 618, 707], 'immune': [31, 330, 619, 708], 'deficiency': [32, 331, 709], '(SCID)': [33, 332, 710, 3377], 'syndrome': [34, 333, 859], '(Feske,': [35, 334], 'S.,': [36, 42, 53, 335, 341, 352], 'Gwack,': [37, 336], 'Y.,': [38, 337], 'Prakriya,': [39, 338], 'M.,': [40, 55, 339, 354], 'Srikanth,': [41, 340], 'Puppel,': [43, 342], 'S.': [44, 343, 683, 775, 804, 824, 884, 890, 946, 952, 1012, 1018, 1063, 1086, 1176, 1209, 1213, 1271, 1461, 1549, 1555, 1580, 1582, 1683, 1689, 1767, 1773, 1831, 1864, 1866, 2066, 3011, 3136, 3205, 3218, 3222, 3564, 3807, 3809, 4166, 4199, 4201, 4235, 4507, 4513], 'H.,': [45, 344], 'Tanasa,': [46, 345], 'B.,': [47, 346], 'Hogan,': [48, 347], 'P.': [49, 348, 1620, 1898, 2044, 3448, 3542, 4546], 'G.,': [50, 349], 'Lewis,': [51, 350], 'R.': [52, 351, 783, 808, 1092, 1190, 1397, 1622, 1628, 1845, 2505, 2970, 3142, 3253, 3450, 3456, 4180, 4241, 4548], 'Daly,': [54, 353], 'and': [56, 115, 151, 179, 246, 355, 414, 450, 478, 545, 661, 664, 930, 1122, 1129, 1334, 1346, 1959, 1977, 2198, 2200, 2259, 2301, 2304, 2383, 2591, 2645, 2681, 2723, 2946, 3497, 3579, 3631, 3673, 3689, 3745, 3839, 3916, 3932, 4036, 4060, 4082, 4494], 'Rao,': [57, 356], 'A.': [58, 357, 731, 766, 812, 828, 902, 964, 1030, 1051, 1064, 1078, 1090, 1170, 1174, 1186, 1215, 1272, 1387, 1393, 1395, 1567, 1592, 1701, 1785, 1825, 1829, 1841, 1876, 2067, 2096, 2098, 2507, 2960, 2966, 2968, 3130, 3134, 3140, 3193, 3206, 3224, 3243, 3249, 3251, 3565, 3819, 4160, 4164, 4176, 4211, 4229, 4233, 4239, 4525], '(2006)': [59, 358], 'Nature': [60, 359], '441,': [61, 360], '179–185).': [62, 361], 'Although': [63, 362], 'heterozygous': [64, 136, 297, 363, 435, 596, 1657, 1741, 1764, 3583, 3615], 'carriers': [65, 364, 1658, 3584], 'show': [69, 161, 368, 460], 'no': [70, 369, 1676, 1801], 'clinical': [71, 370, 1678], 'symptoms': [72, 371, 1679], 'immunodeficiency,': [74, 373], 'entry': [77, 293, 376, 592, 929, 1010, 1716, 1735, 1762], 'their': [79, 378, 3746], 'T': [80, 379, 643, 1718], 'cells': [81, 380, 668, 920, 1313, 1341, 2331, 2343, 2585, 2764, 2893, 3173, 3704, 3856, 3962, 4394], 'is': [82, 101, 183, 250, 282, 381, 400, 482, 549, 581, 627, 1236, 1296, 1995, 2876, 3514, 3870, 4444, 4462], 'impaired,': [83, 382], 'suggesting': [84, 383], 'gene-dosage': [86, 385, 1758], 'effect': [87, 129, 182, 249, 271, 386, 428, 481, 548, 570, 1759, 2143, 3607, 4090, 4362], 'mutation.': [90, 389], 'We': [91, 225, 390, 524, 4356, 4381, 4433], 'have': [92, 391, 711, 2124, 2986, 4260, 4480], 'recently': [93, 392, 2080, 2948], 'demonstrated': [94, 288, 393, 587, 712, 1424, 2823, 2987, 3161], 'that': [95, 147, 162, 180, 227, 247, 268, 394, 446, 461, 479, 526, 546, 567, 713, 861, 935, 1107, 1135, 1283, 1726, 1750, 1813, 1929, 1988, 2082, 2332, 2824, 2875, 2880, 3068, 3110, 3508, 3627, 3711, 3986, 4087, 4109, 4305, 4414, 4420, 4435, 4482, 4495], 'functional': [97, 396, 1932, 1990, 2084, 3510], 'CRAC': [98, 176, 236, 397, 475, 535, 720, 931, 942, 1144, 1545, 1992, 2156, 2370, 2542, 2853, 2888, 2997, 3084, 3179, 3384, 3429, 3504, 3511, 3749, 3850, 3958, 4134, 4298, 4328, 4398, 4441, 4476], 'channel': [99, 177, 237, 265, 398, 476, 536, 564, 626, 721, 932, 943, 1145, 1251, 1546, 1933, 1993, 2087, 2157, 2192, 2371, 2854, 2889, 2998, 3085, 3180, 3385, 3430, 3512, 3750, 3851, 3959, 4103, 4135, 4299, 4329, 4399, 4442, 4458], 'pore': [100, 238, 399, 537, 1252, 1934, 1994, 3513, 4104, 4115], 'composed': [102, 401, 1996], 'tetrameric': [105, 264, 404, 563, 1999, 2085, 2137, 2297, 2349, 2583, 3518, 3647, 3718, 3771, 3783, 3863, 3966, 4068, 4101, 4291, 4318, 4376, 4386], 'assembly': [106, 281, 405, 580, 1928, 1976, 2000, 3519], 'subunits': [109, 169, 194, 233, 258, 277, 408, 468, 493, 532, 557, 576, 1958, 2003, 2180, 2308, 3420, 3522, 3640, 3683, 3687, 3744, 3926, 3930, 3935, 4065, 4098, 4314, 4342, 4370, 4455, 4485], '(Mignen,': [110, 409], 'O.,': [111, 410], 'Thompson,': [112, 411], 'J.': [113, 118, 120, 412, 417, 419, 736, 793, 806, 831, 1053, 1182, 1261, 1318, 1354, 1370, 1451, 1474, 1490, 1511, 1593, 1618, 1632, 1639, 1837, 1877, 1896, 1905, 2010, 2048, 2239, 2278, 2472, 2487, 2508, 2898, 2920, 2936, 3001, 3024, 3040, 3119, 3195, 3268, 3279, 3310, 3446, 3460, 3467, 3529, 3546, 3820, 3998, 4172, 4212, 4269, 4544], 'L.,': [114, 413], 'Shuttleworth,': [116, 415], 'T.': [117, 416, 1524, 1904, 2058, 3274, 3556], '(2008)': [119, 418], 'Physiol.': [121, 420, 1355, 1371, 2011, 2240, 2279, 2474, 2489, 2509, 2921, 2937, 3120, 3530, 3999, 4270], '586,': [122, 421], '419–425).': [123, 422], 'Therefore,': [124, 423, 3602], 'to': [125, 253, 424, 552, 629, 637, 986, 1238, 1298, 1541, 1796, 1972, 2139, 2169, 2224, 2380, 2459, 2660, 2675, 2725, 2820, 2879, 3073, 3109, 3348, 3391, 3603, 3768, 3985, 4051, 4071, 4123, 4322, 4330, 4349, 4470, 4488, 4499, 4501], 'directly': [126, 425], 'quantify': [127, 426], 'SCID': [132, 275, 431, 574, 858, 1673, 2153, 3611, 4096, 4312], 'mutant': [133, 168, 193, 210, 231, 257, 276, 432, 467, 492, 509, 530, 556, 575, 1433, 1969, 2154, 2179, 3378, 3418, 3580, 3612, 3636, 3678, 3682, 3686, 3692, 3882, 3921, 3925, 3929, 3934, 4017, 4041, 4064, 4097, 4286, 4313, 4341, 4369, 4454, 4484], 'situation,': [137, 436, 3616], 'we': [138, 437, 1941, 2123, 2166, 3617, 4259, 4303], 'generated': [139, 438, 2218, 3618], 'series': [141, 440, 3620], 'concatenated': [143, 442, 1951, 2136, 3623, 3734], 'tetramers': [144, 443, 3624, 3674, 3709, 3736, 3759, 3917], 'included': [148, 447, 3628], 'different': [149, 448, 1954, 2148, 2195, 3597, 3629, 3663, 3862, 3939, 4418], 'numbers': [150, 166, 449, 465, 1955, 2149, 3630, 3739], 'arrangements': [152, 451, 2199, 3632], 'subunits.': [157, 456, 3601, 3638, 4380], 'The': [158, 457, 1982, 2020, 2403, 2428, 3765, 3787, 3865], 'data': [159, 458, 2730, 3904], 'obtained': [160, 459, 921, 2374, 3700, 3910, 3987], 'inclusion': [163, 207, 462, 506, 2557, 4061, 4280, 4307], 'increasing': [165, 464], 'graded': [173, 270, 472, 569, 4089], 'reduction': [174, 473, 3410, 4028], 'this': [181, 248, 480, 547, 714, 862, 1807, 1943, 1985, 2164, 2452, 2564, 2825, 2859, 3334, 4088, 4390], 'independent': [184, 483, 979], 'spatial': [187, 486, 4450], 'arrangement': [188, 487, 4451], 'or': [189, 488, 1437, 1804, 2387, 4449], 'order': [190, 489], 'tetramer.': [197, 496], 'Macroscopic': [198, 497], 'biophysical': [199, 498], 'properties': [200, 499], 'channels': [203, 502, 1246, 1310, 2543, 3505, 3592, 4497], 'were': [204, 503, 2167, 2252, 2293, 2313, 2344, 2373, 2535, 2544, 2568, 2586, 2643, 2658, 2693, 2716, 2769, 3094, 3641, 3665, 3837, 3886, 4343, 4371], 'unchanged': [205, 504], 'by': [206, 505, 642, 1342, 2254, 2315, 2521, 2547, 2705, 2718, 2771, 2949, 3649, 4378, 4446], 'subunits,': [211, 510, 3425], 'although': [212, 511, 1921, 2076], 'rate': [214, 513], 'at': [215, 514, 2322, 2531, 2571, 2647, 2654, 2795, 2870, 3102, 3345, 3361, 3404, 3721, 3775, 3888, 3976, 4057, 4409], 'which': [216, 515, 995, 1234, 2766], 'current': [218, 517, 2372, 2530, 2794, 2800, 2826, 2861, 3943, 4050, 4443], 'activates': [219, 518], 'on': [220, 262, 291, 519, 561, 590, 1744, 1760, 2155, 2683, 2844, 3748], 'store': [221, 520, 2846], 'depletion': [222, 521], 'was': [223, 522, 937, 975, 1736, 1748, 1815, 2023, 2217, 2320, 2457, 2519, 2739, 2827, 4320, 4415], 'slowed.': [224, 523], 'conclude': [226, 525, 4434], 'incorporation': [228, 273, 527, 572, 2146, 4093], 'affects': [239, 538], 'overall': [241, 540], 'magnitude': [242, 541, 3955, 4437], 'its': [244, 543, 2839], 'conductance': [245, 544, 4131], 'related': [251, 550], 'solely': [252, 551], 'number': [255, 554, 2305], 'incorporated.': [259, 558], 'Predictions': [260, 559], 'based': [261, 560], 'structure': [266, 565, 2088], 'indicate': [267, 566], 'into': [278, 577, 1974, 2295, 4043, 4345], 'such': [279, 578, 651, 1009, 1293, 1734, 2539, 4020], 'an': [280, 579, 938, 1005, 1442, 2030, 2226, 2357, 2792, 2988, 3337, 3722, 4025, 4039, 4384], 'quantitatively': [283, 582, 2140, 3604], 'consistent': [284, 583, 3077], 'with': [285, 584, 696, 703, 1300, 1411, 2093, 2194, 2346, 2356, 2555, 2580, 2588, 2695, 2745, 2831, 2838, 3421, 3706, 3841, 4014, 4111, 4422, 4490], 'previously': [287, 586, 2231, 2270, 3112, 3435, 4261], 'impaired': [289, 588, 1738, 3428], 'effects': [290, 589, 2208, 3747], 'recorded': [294, 593, 2881, 3111, 4031, 4049, 4421], 'carriers.': [298, 597, 1742], 'Entry': [598], 'via': [601], '3The': [608], 'abbreviations': [609], 'used': [610, 2125, 3063, 3330], 'are:': [611], 'CRAC,': [612], 'calcium': [613], 'Ca2+;': [615], 'SCID,': [616, 1422], 'deficiency;': [620], 'pF,': [621], 'picofarads;': [622], 'WT,': [623], 'wild': [624], 'type.': [625], 'known': [628], 'play': [630], 'key': [632, 1139], 'role': [633], 'response': [636], 'presentation': [639], 'antigen': [641], 'lymphocytes,': [644], 'inducing': [645], 'activation': [647, 2462], 'transcription': [649], 'factors,': [650], 'as': [652, 1004, 1240, 2184, 2230, 2269, 2299, 2390, 2733, 2753, 3091, 3432, 3667, 3715, 3843, 4125, 4258], 'NFAT,': [653], 'production': [657], 'various': [659, 3163, 3738, 3770], 'cytokines': [660], 'differentiation': [663], 'proliferation': [665], '(1Lewis': [669], 'R.S.': [670, 830, 898, 960, 1026, 1563, 1697, 1781, 2486, 4521], 'Annu.': [671], 'Rev.': [672, 685], 'Immunol.': [673, 686, 794, 814], '2001;': [674, 815], '19:': [675], '497-521Crossref': [676], 'PubMed': [677, 690, 745, 771, 798, 818, 837, 907, 969, 1035, 1068, 1099, 1162, 1201, 1222, 1276, 1329, 1359, 1375, 1406, 1480, 1505, 1535, 1572, 1604, 1650, 1706, 1790, 1856, 1888, 1916, 2015, 2071, 2113, 2244, 2283, 2478, 2493, 2513, 2909, 2925, 2941, 2979, 3030, 3055, 3124, 3153, 3210, 3231, 3262, 3290, 3321, 3478, 3534, 3569, 3831, 4003, 4152, 4191, 4223, 4252, 4274, 4530], 'Scopus': [678, 691, 799, 819, 838, 908, 970, 1036, 1069, 1100, 1163, 1202, 1223, 1277, 1330, 1360, 1376, 1407, 1481, 1506, 1536, 1573, 1605, 1651, 1707, 1791, 1857, 1889, 1917, 2016, 2072, 2114, 2245, 2284, 2479, 2494, 2514, 2910, 2926, 2942, 2980, 3031, 3056, 3125, 3154, 3211, 3232, 3263, 3291, 3322, 3479, 3535, 3570, 3832, 4004, 4153, 4192, 4224, 4253, 4275, 4531], '(698)': [679], 'Google': [680, 693, 746, 772, 801, 821, 840, 910, 972, 1038, 1071, 1102, 1165, 1204, 1225, 1279, 1332, 1362, 1378, 1409, 1483, 1508, 1538, 1575, 1607, 1653, 1709, 1793, 1859, 1891, 1919, 2018, 2074, 2116, 2247, 2286, 2481, 2496, 2516, 2912, 2928, 2944, 2982, 3033, 3058, 3127, 3156, 3213, 3234, 3265, 3293, 3324, 3481, 3537, 3572, 3834, 4006, 4155, 4194, 4226, 4255, 4277, 4533], 'Scholar,': [681, 747, 773, 802, 822, 1039, 1072, 1166, 1205, 1363, 1379, 1484, 1509, 1576, 1608, 1860, 1892, 2482, 2497, 2913, 2929, 3034, 3128, 3214, 3235, 3266, 3294, 3538, 4156, 4195, 4227, 4534], '2Feske': [682], 'Nat.': [684, 813, 1400, 2973, 3256], '2007;': [687, 1273, 1356, 1596, 1880, 1908, 2241, 2922, 3121, 3145, 3823, 4215, 4244], '7:': [688], '690-702Crossref': [689], '(771)': [692], 'Scholar).': [694, 841, 911, 973, 1103, 1226, 1280, 1654, 1710, 1794, 2019, 2117, 2248, 2287, 2517, 3157, 3325, 3482, 3835, 4007], 'Consistent': [695], 'this,': [697, 1656], 'studies': [698, 843, 1105, 1423, 1810, 2885, 2985, 4479], 'three': [700, 3685, 3928], 'distinct': [701], 'families': [702], 'members': [704, 1665], 'displaying': [705, 853, 1417, 3593], 'condition': [715, 863], 'resulted': [716, 864, 1124, 3335, 4023, 4395], 'from': [717, 865, 922, 1721, 2396, 2818, 3701, 3911, 4108, 4419], 'defects': [718], 'function': [722], '(3Partiseti': [723], 'M.': [724, 754, 760, 791, 826, 888, 900, 950, 962, 1016, 1028, 1074, 1084, 1168, 1207, 1383, 1391, 1459, 1553, 1565, 1586, 1610, 1616, 1687, 1699, 1771, 1783, 1823, 1870, 2484, 2956, 2964, 3009, 3138, 3216, 3239, 3247, 3438, 3444, 3813, 4158, 4205, 4237, 4511, 4523, 4536, 4542], 'Le': [725], 'Deist': [726, 749], 'F.': [727, 750, 1584, 1868, 3811, 4203], 'Hivroz': [728, 751], 'C.': [729, 752, 756, 785, 1076, 1178, 1257, 1381, 1624, 1638, 1833, 2954, 3132, 3237, 3452, 3466, 4168, 4231], 'Fischer': [730, 765], 'Korn': [732], 'H.': [733, 1088, 1630, 1634, 3458, 3462], 'Choquet': [734, 763], 'D.': [735, 764, 779, 1082], 'Biol.': [737, 1192, 1319, 1402, 1476, 1526, 1594, 1640, 1847, 1878, 1906, 2899, 2975, 3026, 3144, 3258, 3280, 3311, 3468, 3821, 4182, 4213, 4243], 'Chem.': [738, 1320, 1595, 1641, 1879, 1907, 2900, 3281, 3312, 3469, 3822, 4214], '1994;': [739], '269:': [740], '32327-32335Abstract': [741], 'Full': [742, 1196, 1198, 1324, 1326, 1530, 1532, 1599, 1601, 1645, 1647, 1851, 1853, 1883, 1885, 1911, 1913, 2904, 2906, 3148, 3150, 3285, 3287, 3316, 3318, 3473, 3475, 3826, 3828, 4186, 4188, 4218, 4220, 4247, 4249], 'Text': [743, 1197, 1199, 1325, 1327, 1531, 1533, 1600, 1602, 1646, 1648, 1852, 1854, 1884, 1886, 1912, 1914, 2905, 2907, 3149, 3151, 3286, 3288, 3317, 3319, 3474, 3476, 3827, 3829, 4187, 4189, 4219, 4221, 4248, 4250], 'PDF': [744, 1200, 1328, 1534, 1603, 1649, 1855, 1887, 1915, 2908, 3152, 3289, 3320, 3477, 3830, 4190, 4222, 4251], '4Le': [748], 'Partiseti': [753], 'Thomas': [755], 'Buc': [757], 'H.A.': [758], 'Oleastro': [759], 'Belohradsky': [761], 'B.': [762, 894, 956, 1022, 1559, 1626, 1693, 1777, 2056, 3302, 3454, 3554, 4517], 'Blood.': [767], '1995;': [768], '85:': [769], '1053-1062Crossref': [770], '5Feske': [774], 'Muller': [776], 'J.M.': [777, 1172, 1827, 4162], 'Graf': [778], 'Kroczek': [780], 'R.A.': [781], 'Drager': [782], 'Niemeyer': [784], 'Baeuerle': [786], 'P.A.': [787], 'Peter': [788], 'H.H.': [789, 2469], 'Schlesier': [790], 'Eur.': [792], '1996;': [795], '26:': [796], '2119-2126Crossref': [797], '(101)': [800], '6Feske': [803], 'Giltnane': [805], 'Dolmetsch': [807], 'Staudt': [809], 'L.M.': [810], 'Rao': [811, 827, 901, 963, 1029, 1214, 1566, 1591, 1700, 1784, 1875, 3223, 3818, 4210, 4524], '2:': [816], '316-324Crossref': [817], '(495)': [820], '7Feske': [823], 'Prakriya': [825, 887, 949, 1015, 1552, 1686, 1770, 4510], 'Lewis': [829, 897, 959, 1025, 1562, 1696, 1780, 2485, 4520], 'Exp.': [832], 'Med.': [833], '2005;': [834, 1477, 1502, 1527, 3027, 3052], '202:': [835], '651-662Crossref': [836], '(197)': [839], 'Subsequent': [842], 'involving': [844, 2033, 2129], 'modified': [846], 'genetic': [847], 'linkage': [848], 'analysis': [849, 2205, 2815], 'two': [851, 1672, 3681, 3924, 4310, 4340, 4368], 'siblings': [852], 'revealed': [860, 1725, 1987, 2788], 'homozygous': [867], 'novel': [871], 'plasma': [872, 4503], 'membrane': [873, 4504], 'protein': [874, 918, 1119, 1448, 2361, 3784], 'named': [875], 'single': [879, 3677, 4011, 4284], 'point': [880], '(R91W)': [882, 3635], '(8Feske': [883, 945, 1011, 1548, 1682, 1766, 4506], 'Gwack': [885, 947, 1013, 1210, 1550, 1684, 1768, 3219, 4508], 'Y.': [886, 948, 1014, 1047, 1153, 1211, 1255, 1488, 1551, 1578, 1685, 1769, 1862, 2052, 2054, 3038, 3189, 3220, 3550, 3552, 3805, 4143, 4197, 4509], 'Srikanth': [889, 951, 1017, 1212, 1554, 1579, 1688, 1772, 1863, 3221, 3806, 4198, 4512], 'Puppel': [891, 953, 1019, 1556, 1690, 1774, 4514], 'S.H.': [892, 954, 1020, 1557, 1691, 1775, 4515], 'Tanasa': [893, 955, 1021, 1558, 1692, 1776, 4516], 'Hogan': [895, 957, 1023, 1216, 1560, 1589, 1694, 1778, 1873, 3225, 3816, 4208, 4518], 'P.G.': [896, 958, 1024, 1217, 1561, 1590, 1695, 1779, 1874, 3226, 3817, 4209, 4519], 'Daly': [899, 961, 1027, 1564, 1698, 1782, 4522], 'Nature.': [903, 965, 1031, 1158, 1218, 1501, 1568, 1702, 1786, 2109, 3051, 3227, 4148, 4526], '2006;': [904, 966, 1032, 1065, 1096, 1159, 1193, 1219, 1403, 1569, 1703, 1787, 1848, 2976, 3207, 3228, 3259, 3282, 3313, 4149, 4183, 4527], '441:': [905, 967, 1033, 1570, 1704, 1788, 4528], '179-185Crossref': [906, 968, 1034, 1571, 1705, 1789, 4529], '(1821)': [909, 971, 1037, 1574, 1708, 1792, 4532], 'Critically,': [912], 'wild-type': [916, 1427, 3168, 3423, 3578, 3670, 3877, 3913, 3965, 4012, 4379, 4492], 'these': [923, 1339, 1722, 1745, 2296, 2848, 2892, 3088, 3600, 4075, 4453], 'patients': [924, 1416, 1674], 'reconstituted': [925], 'normal': [926, 991, 3494], 'currents,': [933], 'demonstrating': [934], 'essential': [939, 1006, 1446, 2989], 'component': [940], 'activity': [944, 2999], 'This': [974, 2518, 2799, 3409, 4117], 'further': [976, 4046, 4072], 'confirmed': [977, 2314, 2520], 'genome-wide': [980], 'Drosophila': [981, 999], 'RNA': [982], 'interference': [983], 'screens': [984], 'designed': [985, 2134, 2458, 4383], 'identify': [987], 'components': [988], 'critical': [989], 'for': [990, 1008, 2337, 2523, 2651, 2678, 2991, 3902, 3941, 4129], 'entry,': [994], 'identified': [996], 'dOrai,': [997], 'homolog': [1000], 'mammalian': [1002, 1991], 'Orai1,': [1003, 1428], 'factor': [1007], '9Zhang': [1040], 'S.L.': [1041, 1149, 1467, 1486, 2102, 3017, 3036, 3183, 4139], 'Yeromin': [1042, 1454, 2099, 3004, 3184], 'A.V.': [1043, 1147, 1455, 2100, 3005, 3185, 4137], 'Zhang': [1044, 1148, 1460, 2101, 3010, 3186, 4138], 'X.H.': [1045, 3187], 'Yu': [1046, 1152, 1487, 3037, 3188, 4142], 'Safrina': [1048, 1154, 1462, 2103, 3012, 3190, 4144], 'O.': [1049, 1155, 1315, 1349, 1365, 1463, 2005, 2104, 2234, 2273, 2895, 2915, 2931, 3013, 3114, 3191, 3524, 3993, 4145, 4264], 'Penna': [1050, 3192], 'Roos': [1052, 1489, 3039, 3194], 'Stauderman': [1054, 1472, 1497, 3022, 3047, 3196], 'K.A.': [1055, 1473, 1498, 3023, 3048, 3197], 'Cahalan': [1056, 1156, 1468, 1499, 2107, 2470, 3018, 3049, 3198, 4146], 'M.D.': [1057, 1157, 1469, 1500, 2108, 2471, 3019, 3050, 3199, 4147], 'Proc.': [1058, 1266, 2061, 3200, 3559], 'Natl.': [1059, 1267, 2062, 3201, 3560], 'Acad.': [1060, 1268, 2063, 3202, 3561], 'Sci.': [1061, 1269, 2064, 3203, 3562], 'U.': [1062, 1270, 2065, 3204, 3563], '103:': [1066, 3208], '9357-9362Crossref': [1067, 3209], '(736)': [1070, 3212], '10Vig': [1073], 'Peinelt': [1075, 1177, 1832, 2950, 3131, 4167, 4230], 'Beck': [1077, 1169, 1386, 1824, 2959, 3133, 3242, 4159, 4232], 'Koomoa': [1079, 1179, 1384, 1834, 2957, 3240, 4169], 'D.L.': [1080, 1180, 1184, 1263, 1385, 1835, 1839, 2958, 3241, 3278, 4170, 4174], 'Rabah': [1081], 'Koblan-Huberson': [1083, 1390, 2963, 3246], 'Kraft': [1085], 'Turner': [1087], 'Fleig': [1089, 1185, 1394, 1840, 2506, 2967, 3139, 3250, 4175, 4238], 'Penner': [1091, 1189, 1396, 1844, 2504, 2969, 3141, 3252, 4179, 4240], 'Kinet': [1093, 1187, 1398, 1842, 2971, 3254, 4177], 'J.P.': [1094, 1188, 1399, 1843, 2972, 3255, 4178], 'Science.': [1095], '312:': [1097], '1220-1223Crossref': [1098], '(1137)': [1101], 'Finally,': [1104], 'showed': [1106, 3710], 'mutations': [1108], 'conserved': [1110], 'acidic': [1111], 'residues': [1112], 'predicted': [1114], 'transmembrane': [1115], 'regions': [1116], '(specifically': [1120], 'Glu106': [1121], 'Glu190)': [1123], 'changes': [1126, 2526, 2540], 'permeation': [1128], 'selectivity': [1130], 'conductance,': [1133], 'confirming': [1134], 'constitutes': [1137], 'pore-forming': [1140], 'subunit': [1141, 1243, 2196, 3679, 3922, 4013, 4018, 4042, 4287], '(11Yeromin': [1146, 4136], 'Jiang': [1150, 4140], 'W.': [1151, 2042, 3276, 3540, 4141], '443:': [1160, 1220, 3229, 4150], '226-229Crossref': [1161, 4151], '(686)': [1164, 4154], '12Vig': [1167, 4157], 'Billingsley': [1171, 1826, 4161], 'Lis': [1173, 1392, 1828, 2965, 3248, 4163], 'Parvez': [1175, 1830, 3135, 4165, 4234], 'Soboloff': [1181, 1836, 4171], 'Gill': [1183, 1838, 3277, 4173], 'Curr.': [1191, 1525, 1846, 3143, 4181, 4242], '16:': [1194, 1849, 4184], '2073-2079Abstract': [1195, 1850, 4185], '(482)': [1203, 1858, 4193], '13Prakriya': [1206, 3215], 'Feske': [1208, 1581, 1865, 3217, 3808, 4200], '230-233Crossref': [1221, 3230], '(1091)': [1224, 3233], 'An': [1227], 'alternative': [1228], 'view': [1229], 'has': [1230, 1799, 2079, 3159, 3433, 4120], 'been': [1231, 1800, 2334, 3070, 3160, 3434, 4121], 'proposed': [1232], 'believed': [1237], 'act': [1239, 4124], 'regulatory': [1242, 1447], 'TRPC': [1245, 1285], 'rather': [1247], 'than': [1248], 'forming': [1249], 'itself': [1253], '(14Liao': [1254], 'Erxleben': [1256], 'Yildirim': [1258], 'E.': [1259], 'Abramowitz': [1260], 'Armstrong': [1262], 'Birnbaumer': [1264], 'L.': [1265, 1902, 2050, 2060, 3548, 3558], '104:': [1274], '4682-4687Crossref': [1275], '(259)': [1278], 'However,': [1281, 1795, 4333], 'given': [1282], 'proteins': [1286, 3719], 'typically': [1287], 'essentially': [1289, 4052], 'nonselective': [1290], 'cation': [1291], 'proposal': [1295], 'difficult': [1297], 'reconcile': [1299], 'highly': [1302], 'calcium-selective': [1303], 'nature': [1304], 'both': [1306, 3577], 'endogenous': [1308, 2887, 3422], 'HEK293': [1312, 2211, 2763, 3065], '(15Mignen': [1314, 2894], 'Shuttleworth': [1316, 1352, 1368, 2008, 2237, 2276, 2896, 2918, 2934, 3117, 3527, 3996, 4267], 'T.J.': [1317, 1353, 1369, 1494, 2009, 2238, 2277, 2897, 2919, 2935, 3044, 3118, 3528, 3997, 4268], '2000;': [1321, 2901], '275:': [1322, 2902], '9114-9119Abstract': [1323, 2903], '(175)': [1331, 2911], 'Scholar)': [1333, 1539, 2945], 'conductances': [1336], 'induced': [1337], 'same': [1340, 2021, 3370], 'co-expression': [1343], 'STIM1': [1347, 1449, 2094, 2216, 2992, 3080, 3176], '(16Mignen': [1348, 2233, 3113], 'Thompson': [1350, 1366, 2006, 2235, 2274, 2916, 2932, 3115, 3525, 3994, 4265], 'J.L.': [1351, 1367, 2007, 2236, 2275, 2917, 2933, 3116, 3526, 3995, 4266], '579:': [1357, 2242, 2923, 3122], '703-715Crossref': [1358, 2243, 2924, 3123], '(154)': [1361, 2246, 2927, 3126], '17Mignen': [1364, 2930], '2008;': [1372, 1642, 2012, 2068, 2110, 2280, 2938, 3470, 3531, 3566, 4000, 4271], '586:': [1373, 2013, 2281, 2939, 3532, 4001, 4272], '185-195Crossref': [1374, 2940], '(131)': [1377, 2943], '18Peinelt': [1380, 3236], 'Vig': [1382, 2955, 3238], 'Nadler': [1388, 2961, 3244], 'M.J.': [1389, 2962, 3245], 'Cell': [1401, 1475, 2974, 3025, 3257], '8:': [1404, 2977, 3260], '771-773Crossref': [1405, 2978, 3261], '(509)': [1408, 2981, 3264], 'Scholar).Consistent': [1410], 'findings': [1413], 'that,': [1425], 'unlike': [1426], 'either': [1435, 2384], 'alone': [1436], 'presence': [1440, 3788], 'excess': [1443], '(19Roos': [1450, 3000], 'DiGregorio': [1452, 3002], 'P.J.': [1453, 3003], 'Ohlsen': [1456, 3006], 'K.': [1457, 1636, 3007, 3464], 'Lioudyno': [1458, 3008], 'Kozak': [1464, 1491, 3014, 3041], 'J.A.': [1465, 1492, 2467, 3015, 3042], 'Wagner': [1466, 3016], 'Velicelebi': [1470, 3020], 'G.': [1471, 3021], '169:': [1478, 3028], '435-445Crossref': [1479, 3029], '(1494)': [1482, 3032], '20Zhang': [1485, 3035], 'Deerinck': [1493, 3043], 'Ellisman': [1495, 3045], 'M.H.': [1496, 3046], '437:': [1503, 3053], '902-905Crossref': [1504, 3054], '(1117)': [1507, 3057], '21Liou': [1510], 'Kim': [1512], 'M.L.': [1513], 'Heo': [1514], 'W.D.': [1515], 'Jones': [1516], 'J.T.': [1517, 3300], 'Myers': [1518], 'J.W.': [1519, 3309], 'Ferrell': [1520], 'Jr.,': [1521, 3308], 'J.E.': [1522], 'Meyer': [1523], '15:': [1528], '1235-1241Abstract': [1529], '(1724)': [1537], 'fails': [1540], 'generate': [1542], 'any': [1543, 2175, 2524, 2538], 'detectable': [1544], '22Gwack': [1577, 1861, 4196], 'Cruz-Guilloty': [1583, 1867, 3810, 4202], 'Oh-Hora': [1585, 1869, 3812, 4204], 'Neems': [1587, 1871, 3814, 4206], 'D.S.': [1588, 1872, 3815, 4207], '282:': [1597, 1881, 1909, 3824, 4216], '16232-16243Abstract': [1598, 1882, 3825, 4217], '(321)': [1606, 1890, 3833, 4225], '23Muik': [1609, 4535], 'Frischauf': [1611, 3439, 4537], 'I.': [1612, 1614, 2106, 3440, 3442, 4538, 4540], 'Derler': [1613, 3441, 4539], 'Fahrner': [1615, 3443, 4541], 'Bergsmann': [1617, 3445, 4543], 'Eder': [1619, 3447, 4545], 'Schindl': [1621, 3449, 4547], 'Hesch': [1623, 3451], 'Polzinger': [1625, 3453], 'Fritsch': [1627, 3455], 'Kahr': [1629, 3457], 'Madl': [1631, 3459], 'Gruber': [1633, 3461], 'Groschner': [1635, 3463], 'Romanin': [1637, 3465], '283:': [1643, 3471], '8014-8022Abstract': [1644, 3472], '(344)': [1652, 3480], 'Despite': [1655, 3483], 'among': [1664], 'extended': [1668], 'family': [1669], 'displayed': [1675, 3492], 'obvious': [1677], 'immunodeficiency': [1681], 'Further': [1711], 'examination': [1712], 'lymphocytes': [1719], 'taken': [1720, 2752], 'individuals,': [1723], 'however,': [1724], 'under': [1727, 1763, 3368], 'conditions': [1728, 1765, 3329], 'limiting': [1730], 'external': [1731], 'concentrations,': [1733], 'significantly': [1737, 4073, 4417], 'Based': [1743], 'findings,': [1746], 'it': [1747, 4461], 'suggested': [1749, 1808], 'probably': [1755, 3796], 'exerts': [1756], 'date,': [1797], 'there': [1798], 'direct': [1802], 'demonstration': [1803], 'quantification': [1805], 'effect.Previous': [1809], 'had': [1811, 2333, 3069], 'indicated': [1812, 3899, 4481], 'capable': [1816], 'assembling': [1818], 'multimeric': [1820], 'complexes': [1821], '(12Vig': [1822], '24Li': [1893], 'Z.': [1894, 2046, 3544], 'Lu': [1895, 2047, 3545], 'Xu': [1897, 1903, 2043, 2057, 3275, 3541, 3555], 'Xie': [1899], 'X.': [1900], 'Chen': [1901, 2053, 2059, 3551, 3557], '29448-29456Abstract': [1910], '(214)': [1918], 'Scholar),': [1920, 2075, 3059, 3573, 4256, 4278], 'precise': [1923], 'stoichiometry': [1924], 'forms': [1930, 2090, 3800], 'remained': [1935], 'unclear.': [1936], 'In': [1937, 2118, 2163, 3366], 'recent': [1939], 'study,': [1940], 'addressed': [1942], 'question': [1944], 'using': [1945, 2029, 2219, 2375, 2741, 2772, 2816], 'approach': [1947, 2032, 2128], 'expressing': [1949, 2215, 3175, 3857, 3963], 'preassembled': [1950, 2135, 4290], 'constructs': [1952, 2138, 2251, 2298, 2312, 3664, 3713, 3772, 4069, 4319], 'comprising': [1953], 'examining': [1960], 'ability': [1962], 'co-expressed': [1965], 'dominant': [1966, 4127], 'negative': [1967, 2796, 4128], '(E106Q)': [1968], 'monomer': [1971], 'incorporate': [1973], 'inhibit': [1978, 2460], 'current.': [1981], 'study': [1986, 2028, 2078, 2120, 3991], '(25Mignen': [2004, 2272, 3523, 3992, 4263], '419-425Crossref': [2014, 2282, 3533, 4002, 4273], '(178)': [2017, 2285, 3536, 4005, 4276], 'conclusion': [2022], 'subsequently': [2024], 'reached': [2025], 'optical': [2031], 'single-molecule': [2035], 'fluorescence': [2036], 'bleaching': [2037], 'TIRF': [2039], 'images': [2040], '(26Ji': [2041], 'Li': [2045, 3543], 'Liu': [2049, 3547], 'Zhan': [2051, 3549], 'Hille': [2055, 3553], '105:': [2069, 3567], '13668-13673Crossref': [2070, 3568], '(218)': [2073, 3571], 'another': [2077], 'claimed': [2081], 'only': [2089, 3396, 4282, 4309], 'upon': [2091], 'interaction': [2092], '(27Penna': [2095], 'Demuro': [2097], 'Parker': [2105], '456:': [2111], '116-120Crossref': [2112], '(319)': [2115], 'reported': [2121, 3436, 4122, 4262], 'here,': [2122], 'above': [2127], 'generation': [2131], 'specifically': [2133], 'examine': [2141, 3605], 'heterozygote': [2161], 'situation.': [2162], 'way,': [2165], 'able': [2168, 4487], 'overcome': [2170], 'problem': [2172], 'inherent': [2173], 'experiment': [2176], 'where': [2177], 'are': [2181, 2731, 2850, 3892, 3898, 4486], 'simply': [2182], 'expressed': [2183, 3417, 3714, 3760], 'monomers,': [2185], 'formation': [2189], 'multiple': [2191], 'subtypes': [2193], 'composition': [2197, 3866], 'thereby': [2201], 'rendering': [2202], 'detailed': [2203], 'quantitative': [2204], 'impossible.EXPERIMENTAL': [2209], 'PROCEDURESConstructs-A': [2210], 'cell': [2212, 2366, 2757, 3066, 3164, 3698], 'line': [2213, 3067], 'stably': [2214, 3074, 3174], 'Flp-In™-293': [2221], 'system': [2222], '(Invitrogen),': [2223], 'produce': [2225], 'isogenic': [2227], 'STIM1-stable': [2228, 3389, 3763, 3855, 4393], 'line,': [2229], 'described': [2232, 2271, 3092, 4337], 'Tetrameric': [2249], 'prepared': [2253], 'deleting': [2255], 'stop': [2257], 'codon': [2258], 'inserting': [2260], '6-amino': [2262, 3654], 'acid': [2263, 3655], 'linker': [2264, 3656], '(QLNQLE)': [2265], 'between': [2266, 3658], 'each': [2267, 3642, 3659, 3773, 3794, 3858, 3868, 3873, 3903, 4350], 'subunit,': [2268], 'Subunits': [2288], 'incorporated': [2294, 4344], 'appropriate,': [2300], 'orientation': [2303], 'final': [2311], 'restriction': [2316], 'analysis.': [2317], 'Each': [2318], 'construct': [2319, 2350, 2362, 3380, 3648, 3869, 3967, 4293, 4425], 'FLAG-tagged': [2321, 3622, 3708, 3758], 'C-terminal': [2324], 'end.': [2325], 'To': [2326], 'enable': [2327], 'identification': [2328], 'individual': [2330], 'successfully': [2335], 'transfected': [2336, 2345, 3705], 'use': [2338, 2548], 'electrophysiological': [2341], 'experiments,': [2342], 'relevant': [2348], '(0.75': [2351], 'μg': [2352, 2697], 'DNA)': [2354], 'along': [2355], 'enhanced': [2358], 'yellow': [2359], 'fluorescent': [2360], '(0.25': [2363], 'μg).Electrophysiogical': [2364], 'Recording-Whole': [2365], 'recordings': [2367], 'macroscopic': [2369, 3848, 3957], 'sequential': [2376], '250-ms': [2377], 'voltage': [2378], 'pulses': [2379], '+60': [2381, 2532, 2821], 'mV,': [2382, 2389, 2872, 4411], '–40': [2385], 'mV': [2386, 2822, 3104, 3347, 3363, 3406, 3978], '–80': [2388, 2871, 3103, 3346, 3362, 3405, 3889, 3977, 4058, 4410], 'indicated,': [2391], 'delivered': [2392], 'every': [2393], '2': [2394], 's': [2395, 2810], 'holding': [2398], 'potential': [2399, 2834, 3501], '0': [2401], 'mV.': [2402, 2533, 2836, 3890], 'extracellular': [2404], '(bath)': [2405], 'solution': [2406, 2431, 2454, 2553, 2776], 'contained': [2407, 2432], '140': [2408, 2433], 'mm': [2409, 2412, 2415, 2418, 2421, 2424, 2434, 2438, 2441, 2444, 2601, 2606, 2610, 2613, 2619, 2623, 2626, 2672], 'NaCl,': [2410], '1.2': [2411], 'MgCl2,': [2413, 2439], '10': [2414, 2423, 2440, 2443, 2652, 2679], 'CaCl2,': [2416], '5': [2417], 'CsCl,': [2419], '30': [2420], 'd-glucose,': [2422], 'HEPES': [2425, 2445], '(pH': [2426, 2446], '7.4).': [2427], 'internal': [2429, 2797], '(pipette)': [2430], 'Cs+': [2435], 'acetate,': [2436], '4.17': [2437], 'EGTA,': [2442, 2614], '7.2).': [2447], 'Calculated': [2448], 'free': [2449], '[Mg2+]': [2450], 'latter': [2453, 4118], '(3': [2455], 'mm)': [2456], 'MIC/MagNum': [2464], '(28Kozak': [2466], 'Kerschbaum': [2468], 'Gen.': [2473, 2488], '2002;': [2475, 2490, 2510], '120:': [2476], '221-235Crossref': [2477], '(169)': [2480], '29Prakriya': [2483], '119:': [2491], '487-507Crossref': [2492], '(265)': [2495], '30Hermosura': [2498], 'M.C.': [2499], 'Monteilh-Zoller': [2500, 3137, 4236], 'M.K.': [2501], 'Scharenberg': [2502], 'A.M.': [2503], '539:': [2511], '445-458Crossref': [2512], '(165)': [2515], 'checking': [2522], 'significant': [2525], 'outward': [2529], 'Experiments': [2534], 'discarded': [2536], 'if': [2537, 4366], 'occurred.': [2541], 'maximally': [2545], 'activated': [2546, 2770], 'Ca2+-free': [2551, 2774], 'pipette': [2552, 2775], 'together': [2554, 3644], 'adenophostin': [2559, 2784], 'A': [2560, 2785], '(2': [2561, 2786], 'μm)': [2562, 2787], 'solution.': [2565], 'All': [2566], 'experiments': [2567, 3062, 4336], 'carried': [2569], 'out': [2570], 'room': [2572], 'temperature': [2573], '(20–22': [2574], '°C).Western': [2575], 'Blotting-48': [2576], 'h': [2577], 'after': [2578], 'transfection': [2579, 3328], 'appropriate': [2582, 3723], 'construct,': [2584], 'washed': [2587], 'phosphate-buffered': [2589], 'saline': [2590], 'lysed': [2592], '500': [2594], 'μl': [2595], 'lysis': [2597], 'buffer': [2598], 'containing': [2599, 2777, 3675, 3918], '20': [2600], 'Tris-HCl,': [2602], 'pH': [2603], '7.5,': [2604], '150': [2605], 'sodium': [2607, 2620, 2627], 'chloride,': [2608], '1': [2609, 2612, 2622, 2625, 2629, 2696], 'EDTA,': [2611], '1%': [2615], 'Triton': [2616], 'X-100,': [2617], '2.5': [2618], 'pyrophosphate,': [2621], 'β-glycerophosphate,': [2624], 'orthovanadate,': [2628], 'μg/ml': [2630], 'leupeptin': [2631], 'plus': [2632, 2670], 'mini': [2634], 'protease': [2636], 'inhibitor': [2637], 'tablet': [2638], '(Roche': [2639], 'Applied': [2640], 'Science).': [2641], 'Cells': [2642], 'sonicated': [2644], 'spun': [2646], '16,000': [2648], '×': [2649], 'g': [2650], 'min': [2653], '4': [2655], '°C.': [2656], 'Supernatants': [2657], 'added': [2659], '4×': [2661], 'lithium': [2662], 'dodecyl': [2663], 'sulfate': [2664], 'gel': [2665], 'loading': [2666, 3845], 'dye': [2667], '(NuPage;': [2668], 'Invitrogen)': [2669], '50': [2671], 'dithiothreitol,': [2673], 'heated': [2674], '70': [2676], '°C': [2677], 'min,': [2680], 'run': [2682, 3774], '7%': [2685], 'SDS-polyacrylamide': [2686], 'gel,': [2687], 'before': [2688], 'transfer': [2689], 'onto': [2690], 'nitrocellulose.': [2691], 'Blots': [2692], 'probed': [2694], 'ml–1': [2698], 'anti-FLAG': [2699], 'M2': [2700], 'monoclonal': [2701], 'antibody': [2702, 2712], '(Sigma),': [2703], 'followed': [2704], '1:2000': [2706], 'goat': [2707], 'anti-mouse': [2708], 'IgG-horseradish': [2709], 'peroxidase': [2710], 'secondary': [2711], '(Bio-Rad).': [2713], 'Labeled': [2714], 'bands': [2715, 3766], 'visualized': [2717], 'chemiluminescence': [2719], '(Western': [2720], 'Lightning;': [2721], 'Pierce)': [2722], 'exposure': [2724], 'Biomax': [2726], 'XAR': [2727], 'film.Data': [2728], 'Analysis-All': [2729], 'presented': [2732], 'mean': [2734, 3351, 3393, 3893], '±': [2735, 2864, 3096, 3355, 3398, 3894, 3970, 4403, 4427], 'S.E.': [2736], 'Statistical': [2737], 'significance': [2738], 'determined': [2740], "Student's": [2742], 't': [2743], 'test,': [2744], 'value': [2747, 2807, 2874, 3352, 3394, 3874, 3982, 4413], 'p': [2749], '<': [2750], '0.05': [2751], 'significant.RESULTS': [2754], 'AND': [2755], 'DISCUSSIONWhole': [2756], 'patch': [2758], 'clamp': [2759], 'determinations': [2760], 'untransfected': [2762], 'potent': [2779], 'inositol': [2780], '1,4,5-trisphosphate': [2781], 'receptor': [2782], 'agonist': [2783], 'development': [2790], 'inward': [2793, 2860, 3342, 3383, 3495, 3849, 4397], 'potentials.': [2798], 'developed': [2801], 'relatively': [2802], 'slowly,': [2803], 'reaching': [2804], 'maximum': [2806], '∼60–100': [2809], '(data': [2811], 'not': [2812, 4416], 'shown).': [2813], 'Current/voltage': [2814], 'ramps': [2817], '–100': [2819], 'markedly': [2828, 4107], 'inwardly': [2829], 'rectifying,': [2830], 'reversal': [2833, 3500], '>+60': [2835], 'Along': [2837], 'appearance': [2840], 'being': [2841], 'strictly': [2842], 'dependent': [2843], 'depletion,': [2847], 'features': [2849], 'characteristic': [2851, 3502], 'activity.': [2855], 'Maximum': [2856], 'values': [2857, 3897, 4054], 'averaged': [2862, 3968], '0.42': [2863], '0.03': [2865], 'pA/pF': [2866, 3098, 3357, 3400, 3972, 4056, 4405], '(n': [2867, 3099, 3358, 3401, 3973, 4406], '=': [2868, 3100, 3359, 3402, 3974, 4407, 4431], '5)': [2869, 3101], 'very': [2877, 3498, 3983, 4076], 'similar': [2878, 3108, 3984], 'our': [2883, 3332, 3989], 'previous': [2884], '16Mignen': [2914], 'more': [2947], 'et': [2951], 'al.': [2952], '(18Peinelt': [2953], 'Scholar).Because': [2983], 'several': [2984], 'requirement': [2990], 'regulation': [2995], 'all': [3060, 3491, 3712], 'subsequent': [3061], 'isogenically': [3071], 'engineered': [3072], 'express': [3075], 'level': [3078], '(STIM1-stable': [3081], 'cells).': [3082], 'Mean': [3083], 'cells,': [3089, 3390], 'measured': [3090, 3344, 3853, 3887], 'above,': [3093, 4302, 4338], '0.77': [3095], '0.09': [3097], '(Fig.': [3105, 3364, 3407, 3506, 3730, 3979, 4033, 4079], '1A),': [3106], 'again': [3107], '31Lis': [3129, 4228], '17:': [3146, 4245], '794-800Abstract': [3147, 4246], '(317)': [3155, 4254], 'As': [3158], 'types,': [3165], 'monomers': [3170], 'profoundly': [3177], 'increased': [3178], '(9Zhang': [3182], '32Soboloff': [3267], 'Spassova': [3269], 'M.A.': [3270], 'Tang': [3271], 'X.D.': [3272], 'Hewavitharana': [3273], '281:': [3283, 3314], '20661-20665Abstract': [3284], '(481)': [3292], '33Mercer': [3295], 'J.C.': [3296], 'Dehaven': [3297], 'W.I.': [3298], 'Smyth': [3299], 'Wedel': [3301], 'Boyles': [3303], 'R.R.': [3304], 'Bird': [3305], 'G.S.': [3306], 'Putney': [3307], '24979-24990Abstract': [3315], '(470)': [3323], 'Under': [3326], 'studies,': [3333], 'approximately': [3338, 3776, 4026], '4.8-fold': [3339], 'increase': [3340], 'reach': [3349], '3.68': [3354], '0.68': [3356], '14)': [3360], '1A).': [3365, 3408], 'contrast,': [3367], 'conditions,': [3371], 'monomeric': [3375], 'actually': [3381], 'reduced': [3382, 4047], '0.41': [3397], '0.06': [3399], '13)': [3403], 'presumably': [3411], 'reflects': [3412, 3797], 'association': [3414], 'activity,': [3431], '(23Muik': [3437], 'differences': [3485], 'magnitude,': [3487], 'current-voltage': [3489, 3908], 'relationships': [3490, 3909], 'rectification': [3496], 'positive': [3499], '1B).Given': [3507], 'comprised': [3515], '26Ji': [3539], 'can': [3589], 'result': [3590], 'variety': [3595], 'combinations': [3598], 'These': [3639], 'linked': [3643], 'insertion': [3650], 'short,': [3653], 'sequence': [3657, 4377], 'subunit.': [3660], 'Initially,': [3661], 'five': [3662, 3861], 'assembled,': [3666], 'follows:': [3668], 'tetramer': [3671, 3693, 3803, 3914, 4022, 4045, 4347], '(WT-WT-WT-WT)': [3672], '(WT-WT-WT-R91W),': [3680], '(R91W-R91W-WT-WT),': [3684], '(R91W-R91W-WT-R91W),': [3688], 'fully': [3691], '(R91W-R91W-R91W-R91W).': [3694], 'Western': [3695, 3754], 'blots': [3696], 'lysates': [3699], 'populations': [3702], 'intact': [3716], 'full-length': [3717], 'running': [3720], 'apparent': [3724], 'molecular': [3725, 3779], 'mass': [3726, 3780], '∼130–140': [3728], 'kDa': [3729], '2A).FIGURE': [3731], '2Expression': [3732], 'incorporating': [3737], 'currents.': [3751], 'A,': [3752], 'representative': [3753, 3907], 'blot': [3755], 'cells.': [3764], 'corresponding': [3767], 'anticipated': [3778], '(∼130–140': [3785], 'kDa).': [3786], 'double': [3791], 'band': [3792], 'case': [3795], 'differentially': [3798], 'glycosylated': [3799], '(22Gwack': [3804], 'Gels': [3836], 'stripped': [3838], 'reprobed': [3840], 'β-actin': [3842], 'control.': [3846], 'B,': [3847], 'constructs.': [3864], 'represented': [3871], 'below': [3872], '(open': [3875], 'circles,': [3876, 3880], 'subunit;': [3878], 'filled': [3879], 'subunits).': [3883], 'Inward': [3884], 'Values': [3891], 'S.E.;': [3895], 'n': [3896, 4430], 'brackets': [3901], 'set.': [3905], 'C,': [3906], '(i)': [3915], 'one': [3919], '(ii),': [3923], '(iii),': [3927], '(iv),': [3931], 'four': [3933], '(v).': [3936], 'Note': [3937], 'scales': [3940], 'densities.View': [3944], 'Large': [3945], 'Image': [3946], 'Figure': [3947], 'ViewerDownload': [3948], 'Hi-res': [3949], 'image': [3950], 'Download': [3951], '(PPT)Analysis': [3952], '4.23': [3969], '0.79': [3971], '7)': [3975, 4408], '2B),': [3980], 'earlier': [3990], 'Substitution': [4008], '50%': [4027], '2,': [4034, 4080], 'B': [4035, 4081], 'C).': [4037], 'Incorporating': [4038], 'additional': [4040, 4063], 'negligible': [4053, 4331], '(<0.4': [4055], 'mV),': [4059], 'failed': [4070], 'affect': [4074, 4471], 'small': [4077], 'C).It': [4083], 'should': [4084], 'be': [4085, 4364], 'noted': [4086, 4301], 'assemblies': [4105], 'differs': [4106], 'seen': [4110], 'E106Q': [4113, 4285], 'mutant.': [4116], 'and,': [4257], 'effectively': [4294, 4323], 'eliminates': [4295], 'currents.As': [4300], 'found': [4304], 'sufficient': [4321], 'reduce': [4324], 'values.': [4332], 'adjacent': [4348], 'other': [4351], 'tandem': [4354], 'pairing.': [4355], 'therefore': [4357, 4382], 'wondered': [4358], 'whether': [4359], 'observed': [4361], 'may': [4363], 'altered': [4365], 'separated': [4372], 'linear': [4375], 'R91W-WT-R91W-WT': [4385], 'construct.': [4387], 'Expression': [4388], '0.34': [4402], '0.04': [4404], 'R91W-R91W-WT-WT': [4424], '(0.36': [4426], '0.07': [4428], 'pA/pF,': [4429], '13).': [4432], 'unaffected': [4445], 'placement': [4448], 'around': [4456], 'pore.As': [4459], 'yet,': [4460], 'unclear': [4463], 'exactly': [4464], 'how': [4465], 'acts': [4469], 'behavior': [4473], 'channel.': [4477], 'Previous': [4478], 'co-assemble': [4489], 'appear': [4498], 'traffic': [4500], 'normally': [4505], 'H': [4549]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2029370006', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-04T16:02:12.369378', 'created_date': '2016-06-24'}