Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2029117904', 'doi': 'https://doi.org/10.1007/s004320000119', 'title': 'Cytotoxicity of millimolar concentrations of ethanol on HepG2 human tumor cell line compared to normal rat hepatocytes in vitro', 'display_name': 'Cytotoxicity of millimolar concentrations of ethanol on HepG2 human tumor cell line compared to normal rat hepatocytes in vitro', 'publication_year': 2000, 'publication_date': '2000-08-10', 'ids': {'openalex': 'https://openalex.org/W2029117904', 'doi': 'https://doi.org/10.1007/s004320000119', 'mag': '2029117904', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11003562'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s004320000119', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10075937', 'display_name': 'Journal of Cancer Research and Clinical Oncology', 'issn_l': '0171-5216', 'issn': ['0171-5216', '1432-1335'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051395895', 'display_name': 'Francisco Castañeda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210130622', 'display_name': 'Max Planck Institute of Molecular Physiology', 'ror': 'https://ror.org/03vpj4s62', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210130622']}, {'id': 'https://openalex.org/I149899117', 'display_name': 'Max Planck Society', 'ror': 'https://ror.org/01hhn8329', 'country_code': 'DE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I149899117']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'F. Castañeda', 'raw_affiliation_strings': ['Max Planck Institute of Molecular Physiology, Max Planck Society'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute of Molecular Physiology, Max Planck Society', 'institution_ids': ['https://openalex.org/I4210130622', 'https://openalex.org/I149899117']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017423382', 'display_name': 'Rolf K. H. Kinne', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210130622', 'display_name': 'Max Planck Institute of Molecular Physiology', 'ror': 'https://ror.org/03vpj4s62', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210130622']}, {'id': 'https://openalex.org/I149899117', 'display_name': 'Max Planck Society', 'ror': 'https://ror.org/01hhn8329', 'country_code': 'DE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I149899117']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'R. K. H. Kinne', 'raw_affiliation_strings': ['Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society'], 'affiliations': [{'raw_affiliation_string': 'Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society', 'institution_ids': ['https://openalex.org/I4210130622', 'https://openalex.org/I149899117']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3190, 'currency': 'EUR', 'value_usd': 4190, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.51, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.742571, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '126', 'issue': '9', 'first_page': '503', 'last_page': '510'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12910', 'display_name': 'Metabolism and Function of Arachidonic Acid Derivatives', 'score': 0.5427, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12910', 'display_name': 'Metabolism and Function of Arachidonic Acid Derivatives', 'score': 0.5427, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Methods in Drug Discovery', 'score': 0.472, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fragmentation', 'display_name': 'Fragmentation (computing)', 'score': 0.495746}, {'id': 'https://openalex.org/keywords/metabolism', 'display_name': 'Metabolism', 'score': 0.458929}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.71986985}, {'id': 'https://openalex.org/C43759708', 'wikidata': 'https://www.wikidata.org/wiki/Q3749256', 'display_name': 'DNA fragmentation', 'level': 4, 'score': 0.6096651}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.57112294}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5574905}, {'id': 'https://openalex.org/C2776200302', 'wikidata': 'https://www.wikidata.org/wiki/Q827450', 'display_name': 'Hepatocyte', 'level': 3, 'score': 0.55419976}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.55365777}, {'id': 'https://openalex.org/C503630168', 'wikidata': 'https://www.wikidata.org/wiki/Q178069', 'display_name': 'Necrosis', 'level': 2, 'score': 0.520075}, {'id': 'https://openalex.org/C2780161600', 'wikidata': 'https://www.wikidata.org/wiki/Q153', 'display_name': 'Ethanol', 'level': 2, 'score': 0.51216197}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.50295633}, {'id': 'https://openalex.org/C191015642', 'wikidata': 'https://www.wikidata.org/wiki/Q1132459', 'display_name': 'Fragmentation (computing)', 'level': 2, 'score': 0.495746}, {'id': 'https://openalex.org/C2777318727', 'wikidata': 'https://www.wikidata.org/wiki/Q409464', 'display_name': 'Lactate dehydrogenase', 'level': 3, 'score': 0.49570692}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.4574546}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.42717594}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.42503113}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.4163106}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.40208554}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3577577}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.21918944}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.09376791}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000431', 'descriptor_name': 'Ethanol', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000426', 'descriptor_name': 'Alcohol Dehydrogenase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D000426', 'descriptor_name': 'Alcohol Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053938', 'descriptor_name': 'DNA Fragmentation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D053938', 'descriptor_name': 'DNA Fragmentation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000431', 'descriptor_name': 'Ethanol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077604', 'descriptor_name': 'Fomepizole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007770', 'descriptor_name': 'L-Lactate Dehydrogenase', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D007770', 'descriptor_name': 'L-Lactate Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009336', 'descriptor_name': 'Necrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s004320000119', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10075937', 'display_name': 'Journal of Cancer Research and Clinical Oncology', 'issn_l': '0171-5216', 'issn': ['0171-5216', '1432-1335'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11003562', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.56, 'id': 'https://metadata.un.org/sdg/2', 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W923632057', 'https://openalex.org/W3193503205', 'https://openalex.org/W3032184365', 'https://openalex.org/W2395877311', 'https://openalex.org/W2381433196', 'https://openalex.org/W2079630091', 'https://openalex.org/W2003827594', 'https://openalex.org/W1997209091', 'https://openalex.org/W1989087147', 'https://openalex.org/W1970929176'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2029117904', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-15T06:13:51.588907', 'created_date': '2016-06-24'}