Epigallocatechin-3-gallate Inhibits Epidermal Growth Factor Receptor Signaling Pathway

Name: Work Video:
Duration: 3 min 30 s
Jerome F. Sah; Sivaprakasam Balasubramanian; Richard L. Eckert; Ellen A. Rorke
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'https://openalex.org/W2469555320', 'https://openalex.org/W2335356391', 'https://openalex.org/W2325450529', 'https://openalex.org/W2140242228', 'https://openalex.org/W2069915122', 'https://openalex.org/W1898984969', 'https://openalex.org/W146556653'], 'abstract_inverted_index': {'Epidermal': [0, 195], 'growth': [1, 48, 196, 243, 411, 469, 624, 1247, 1769, 2318, 2950, 3011, 4807], 'factor': [2, 197, 625], 'receptor': [3, 198, 626], '(EGFR)': [4, 199], 'activation': [5, 50, 55, 176, 200, 245, 250, 371, 2404, 2474, 2602, 2651, 2658, 2703, 3737, 4516], 'is': [6, 76, 167, 201, 271, 362, 392, 518, 908, 977, 987, 1030, 2315, 2422, 2436, 2461, 2550, 2605, 2891, 3199, 3676, 3733, 3749, 3890, 3952, 3998, 4007, 4031, 4057, 4062, 4389, 4507, 4519, 4546, 4555, 4562, 4575, 4763, 4811, 4846, 4864, 4875, 5009, 5028, 5034, 5040, 5056, 5068, 5116, 5156, 5162, 5178, 5188, 5276, 5305, 5323], 'absolutely': [7, 202], 'required': [8, 203, 2316, 4629, 4767, 5004], 'for': [9, 204, 981, 1291, 1554, 1578, 1628, 1708, 1719, 1790, 1817, 1839, 1904, 1912, 1958, 2129, 2276, 2317, 2384, 2392, 3043, 3063, 3173, 3184, 3220, 3310, 3346, 3370, 3567, 4521, 4630, 4716, 4728, 4768], 'cervical': [10, 43, 205, 238, 545, 737, 863, 963, 999, 1292, 1300, 1304, 3100, 3627, 3759, 5314, 5319, 5413], 'cell': [11, 134, 193, 206, 329, 388, 559, 565, 809, 864, 1157, 1250, 1664, 1997, 2556, 2612, 2896, 2949, 2953, 2967, 3010, 3024, 3057, 3101, 3129, 3137, 3141, 3152, 3761, 3874, 4503, 4522, 4525, 4694, 4769, 4887, 5225], 'proliferation.': [12, 194, 207, 389, 3058, 4664], 'This': [13, 208, 1242, 3194, 3731, 3888, 4060, 4869, 5059, 5170, 5330], 'suggests': [14, 209, 5060, 5403], 'that': [15, 144, 152, 182, 210, 339, 347, 377, 557, 993, 1219, 1258, 1283, 1853, 2874, 2969, 3031, 3170, 3324, 3634, 3655, 3674, 3725, 3861, 4165, 4177, 4352, 4366, 4543, 4654, 4671, 4739, 4803, 4855, 5061, 5084, 5106, 5131, 5173, 5190, 5217, 5274, 5280, 5371, 5392, 5404], 'EGFR-inhibitory': [16, 211], 'agents': [17, 212, 976], 'may': [18, 213, 1260, 1285, 3872, 4658, 4870, 4884, 5134, 5215, 5406], 'be': [19, 214, 1286, 3096, 3132, 4065, 4677, 4766, 4871, 5003, 5102, 5135, 5216, 5407], 'of': [20, 31, 51, 56, 81, 177, 215, 226, 246, 251, 276, 372, 527, 551, 859, 911, 973, 983, 1205, 1276, 1328, 1563, 1574, 1659, 1682, 1953, 2018, 2108, 2118, 2197, 2223, 2229, 2237, 2241, 2289, 2295, 2297, 2319, 2372, 2405, 2448, 2475, 2545, 2603, 2643, 2652, 2659, 2701, 2751, 2762, 2793, 2832, 2848, 2859, 2879, 2941, 2979, 2985, 3021, 3039, 3056, 3135, 3151, 3178, 3191, 3196, 3204, 3226, 3270, 3333, 3339, 3356, 3367, 3396, 3422, 3431, 3565, 3587, 3590, 3611, 3657, 3738, 3744, 3949, 3964, 4019, 4050, 4082, 4486, 4498, 4517, 4551, 4570, 4627, 4663, 4674, 4698, 4733, 4818, 4827, 5021, 5026, 5065, 5071, 5075, 5111, 5114, 5140, 5168, 5176, 5195, 5229, 5233, 5240, 5261, 5270, 5282, 5293, 5313, 5317, 5335, 5379, 5385], 'therapeutic': [21, 216], 'value.': [22, 217], 'In': [23, 136, 218, 331, 940, 1142, 1197, 2523, 2781, 2823, 3236, 3411, 3419, 3530, 4004, 4016, 5365], 'the': [24, 29, 57, 164, 174, 219, 224, 252, 359, 369, 525, 549, 597, 971, 995, 1031, 1198, 1203, 1273, 1318, 1412, 1835, 1862, 1943, 2019, 2195, 2208, 2235, 2272, 2293, 2302, 2370, 2455, 2640, 2656, 2749, 2796, 2801, 2833, 2850, 2857, 2860, 2983, 2986, 3002, 3019, 3133, 3149, 3289, 3353, 3357, 3517, 3524, 3575, 3598, 3609, 3646, 3885, 3953, 4026, 4046, 4077, 4130, 4169, 4230, 4382, 4512, 4549, 4583, 4661, 4672, 4804, 4819, 4860, 4940, 5062, 5069, 5088, 5092, 5107, 5120, 5132, 5174, 5196, 5199, 5205, 5224, 5231, 5253, 5268, 5283, 5299, 5311, 5324, 5333, 5336, 5376, 5383, 5390, 5400], 'present': [25, 220, 1035, 1199, 1661, 3722], 'study,': [26, 221, 1200], 'we': [27, 222, 1201, 3103, 3154, 4652, 4801], 'investigated': [28, 223], 'effects': [30, 225, 2361, 3094, 4673, 4949, 5076, 5228, 5378, 5384], 'epigallocatechin-3-gallate': [32, 227], '(EGCG),': [33, 228], 'a': [34, 229, 393, 521, 588, 638, 909, 1323, 1424, 1593, 1608, 1715, 1981, 2025, 2041, 2049, 2100, 2402, 2415, 2471, 2536, 2767, 2962, 2999, 3027, 3053, 3084, 3247, 3389, 3393, 3640, 3755, 4480, 4717, 4745, 4814, 5072, 5287, 5306], 'bioactive': [35, 230, 1033], 'green': [36, 231, 1021, 1037, 1277], 'tea': [37, 232, 1022, 1278], 'polyphenol,': [38, 233], 'on': [39, 234, 921, 1407, 1705, 1999, 4649, 5077, 5097], 'EGFR': [40, 235, 731, 860, 906, 918, 943, 1210, 1222, 1463, 2312, 2362, 2406, 2434, 2459, 2653, 3680, 3684, 3729, 3965, 4027, 4387, 4487, 5115, 5123], 'signaling': [41, 236, 1211, 3681, 3886, 4762, 4823, 5094], 'in': [42, 71, 237, 266, 524, 641, 736, 1036, 1240, 1253, 1313, 1322, 1366, 1383, 1389, 1399, 1557, 1601, 1607, 1662, 1768, 1788, 1802, 1889, 1940, 1947, 1974, 1989, 2048, 2213, 2258, 2369, 2398, 2408, 2414, 2418, 2426, 2458, 2539, 2611, 2655, 2661, 2743, 2744, 2748, 2757, 2770, 2810, 2957, 2965, 3016, 3033, 3078, 3087, 3114, 3180, 3246, 3250, 3259, 3276, 3285, 3288, 3428, 3441, 3456, 3468, 3511, 3547, 3594, 3633, 3758, 3884, 3895, 4002, 4025, 4047, 4053, 4482, 4511, 4565, 4692, 4744, 4880, 5013, 5091, 5109, 5122, 5126, 5149, 5165, 5191, 5198, 5201, 5207, 5223, 5252, 5286, 5291, 5310, 5327, 5412], 'cells.': [44, 239, 2410, 3193, 3342, 3364, 5263], 'EGCG': [45, 62, 130, 145, 153, 165, 170, 183, 240, 257, 325, 340, 348, 360, 365, 378, 1206, 1220, 1259, 1284, 1363, 1564, 1787, 1911, 2310, 2360, 2383, 2411, 2440, 2444, 2509, 2525, 2534, 2637, 2697, 2706, 2763, 2776, 2788, 2816, 2843, 2868, 2875, 2882, 2946, 2960, 3022, 3067, 3081, 3122, 3124, 3159, 3171, 3227, 3244, 3309, 3403, 3426, 3450, 3459, 3514, 3566, 3726, 3862, 3871, 4001, 4035, 4166, 4367, 4484, 4579, 4665, 4675, 4721, 4741, 5012, 5066, 5085, 5146, 5151, 5251, 5259, 5297, 5380, 5393, 5405], 'inhibits': [46, 64, 147, 241, 259, 342, 862, 1221, 2877, 3540, 3727, 4724, 5086, 5147], 'epidermal': [47, 242, 410, 468, 623], 'factor-dependent': [49, 244], 'EGFR,': [52, 140, 247, 335, 413, 471, 3637, 3745, 4040, 5087], 'and': [53, 73, 87, 97, 104, 115, 149, 248, 268, 282, 292, 299, 310, 344, 555, 564, 596, 602, 633, 733, 857, 947, 967, 1117, 1155, 1212, 1249, 1281, 1296, 1303, 1309, 1361, 1372, 1402, 1421, 1436, 1445, 1452, 1483, 1517, 1531, 1542, 1565, 1605, 1626, 1710, 1714, 1781, 1800, 1823, 1834, 1893, 1907, 1927, 1964, 1978, 1993, 2012, 2030, 2083, 2092, 2105, 2140, 2226, 2248, 2253, 2286, 2292, 2450, 2479, 2516, 2533, 2547, 2558, 2670, 2710, 2729, 2772, 2806, 2820, 2888, 3009, 3068, 3107, 3160, 3182, 3186, 3241, 3252, 3266, 3278, 3313, 3319, 3327, 3349, 3445, 3479, 3495, 3533, 3550, 3574, 3580, 3592, 3602, 3643, 3673, 3740, 3747, 3867, 3958, 3995, 4010, 4022, 4028, 4043, 4069, 4079, 4084, 4128, 4359, 4372, 4376, 4493, 4500, 4502, 4524, 4587, 4666, 4700, 4707, 4710, 4736, 4738, 4760, 4821, 4883, 5048, 5211, 5219, 5237, 5298, 5344, 5387], 'EGFR-dependent': [54, 65, 175, 249, 260, 370, 2446], 'mitogen-activated': [58, 253, 442, 500], 'protein': [59, 254, 438, 443, 447, 496, 501, 505, 948, 2096, 2109, 2189, 2201, 2224, 2290, 3470, 3588, 3600, 4132, 4591], 'kinases': [60, 190, 255, 385, 1237, 2554, 2717, 2732, 2739, 3577, 3753, 3880, 4021, 4836, 5112, 5183, 5245], 'ERK1/2.': [61, 256], 'also': [63, 258, 628, 952, 2606, 3274, 3439, 3490, 3505, 4175, 4228, 4508, 5157], 'AKT': [66, 74, 261, 269, 2480, 2517, 2548, 2647, 2711, 2771, 3866, 4178, 4227, 4354], 'activity.': [67, 108, 262, 303, 1241, 2420, 2467, 2541, 2774, 3508, 3542, 3869, 5080, 5124], 'The': [68, 263, 622, 1581, 1657, 1690, 1700, 1844, 1898, 1915, 1969, 2003, 2148, 2203, 2375, 2395, 2542, 2601, 2737, 3466, 3486, 3604, 3742], 'EGCG-dependent': [69, 125, 264, 320, 2456, 2987, 3268, 4816], 'reduction': [70, 265, 2417, 2457, 2769, 2964, 5108, 5121], 'ERK': [72, 267, 2660, 2702, 2861], 'activity': [75, 270, 734, 861, 926, 1119, 2191, 2314, 2460, 2513, 2518, 2549, 2666, 2784, 2858, 2890, 3520, 3535, 3997, 4012, 4049, 4355, 4545, 4550, 4561, 4569, 4657, 4845, 4851, 5033, 5039, 5050, 5055, 5110, 5148, 5155, 5161, 5177], 'associated': [77, 92, 272, 287, 2462, 2893, 3200, 3473, 3734, 4380], 'with': [78, 93, 110, 273, 288, 305, 807, 905, 1335, 1404, 1419, 1586, 1596, 1619, 1623, 1630, 1784, 1796, 1814, 1910, 1920, 1924, 1929, 1966, 1980, 2014, 2154, 2161, 2217, 2282, 2380, 2429, 2463, 2506, 2664, 2815, 2894, 2992, 3066, 3071, 3110, 3158, 3201, 3224, 3239, 3306, 3315, 3425, 3474, 3562, 3597, 3735, 3879, 3892, 4381, 4621, 5145], 'reduced': [79, 100, 105, 274, 295, 300, 1239, 2423, 2464, 2510, 2818, 2895, 3516, 3736, 4490, 4577, 4655], 'phosphorylation': [80, 275, 2296, 2826, 2878, 4018, 5020], 'downstream': [82, 277, 635, 942, 1213, 1230, 1235, 1264, 2716, 2731, 2836, 4023, 4553, 5025, 5113, 5295], 'substrates,': [83, 278], 'including': [84, 279, 945], 'p90RSK,': [85, 280, 2863, 4574], 'FKHR,': [86, 281, 456, 514, 2800, 4042, 4492], 'BAD.': [88, 283, 4044], 'These': [89, 179, 284, 374, 1266, 2871, 4037, 4162, 4349, 4618, 4713, 5264], 'changes': [90, 285], 'are': [91, 286, 957, 1024, 1238, 2211, 2718, 3212, 3325, 3337, 3361, 3625, 3960, 4379, 4837, 4944, 5051, 5184, 5221, 5248], 'increased': [94, 289, 593, 808, 3140, 3202, 3476, 4370, 4496, 4696, 4704, 4708, 4731, 4752], 'p53,': [95, 290, 4737], 'p21WAF-1,': [96, 291], 'p27KIP-1': [98, 293, 1150], 'levels,': [99, 294, 1151], 'cyclin': [101, 296, 1153, 3481, 3496, 5348], 'E': [102, 297, 1481, 3482, 5349], 'level,': [103, 298, 5343], 'CDK2': [106, 301, 3518, 3541], 'kinase': [107, 302, 439, 497, 949, 2114, 2162, 2190, 2205, 2214, 2260, 2466, 2746, 3519, 3595, 4052, 5079, 5090, 5285], 'Consistent': [109, 304], 'these': [111, 306, 2553, 3093, 3658, 3752, 4477, 4650, 5241], 'findings,': [112, 307], 'flow': [113, 308, 1850, 3165], 'cytometry': [114, 309], 'TUNEL': [116, 311, 1870, 1872, 3390, 4705, 4753], '(terminal': [117, 312], 'deoxynucleotidyl-transferase-mediated': [118, 313], 'dUTP': [119, 314, 427, 485], 'nick': [120, 315, 428, 486], 'end': [121, 316, 429, 487], 'labeling)': [122, 317], 'staining': [123, 318, 1856], 'revealed': [124, 319, 3405], 'G1': [126, 321, 3181, 4383], 'arrest.': [127, 322, 4505], 'Moreover,': [128, 323, 1252, 5016], 'sustained': [129, 324, 4815], 'treatment': [131, 326, 982, 2412, 2441, 2638, 3082, 3172, 3183, 3238, 3404, 3421, 3515, 4167, 4368, 4686, 4742, 5067, 5260, 5394], 'caused': [132, 327, 2766, 2817], 'apoptotic': [133, 328, 1675, 3341, 4747], 'death.': [135, 330, 2954, 3142], 'addition': [137, 332, 2236, 3610], 'to': [138, 159, 185, 191, 333, 354, 380, 386, 599, 630, 916, 954, 1148, 1207, 1227, 1246, 1568, 1778, 1826, 1895, 1902, 2008, 2123, 2207, 2250, 2943, 3006, 3026, 3030, 3074, 3098, 3147, 3526, 3552, 3648, 4064, 4076, 4171, 4489, 4624, 4660, 4688, 4765, 4809, 4813, 4877, 4886, 4946, 5005, 5104, 5119, 5267, 5278, 5382], 'inhibiting': [139, 334, 4353], 'cell-free': [141, 336, 1255, 5128, 5200, 5254], 'studies': [142, 337, 991, 1217, 1256, 1267, 3723, 4541, 5001], 'demonstrated': [143, 338], 'directly': [146, 341, 1261, 2719, 3864], 'ERK1/2': [148, 343, 946, 2512, 2546, 2709, 2773, 2851, 3739, 3748, 3868, 3994, 4513, 4518, 4544, 4552, 4572, 4759, 4820, 5027, 5142, 5218], 'AKT,': [150, 345, 3746], 'suggesting': [151, 346, 992, 4854, 5273], 'acts': [154, 184, 349, 379], 'simultaneously': [155, 350], 'at': [156, 351, 1369, 1374, 1386, 1771, 1820, 1884, 1961, 1995, 2132, 2144, 2279, 2667, 2841, 3556, 3639, 3881], 'multiple': [157, 188, 352, 383, 969, 3882], 'levels': [158, 353, 732, 3296, 3430, 3498, 3883, 4378, 4497, 4732, 5398], 'inhibit': [160, 187, 192, 355, 382, 387, 917, 1152, 1156, 1208, 1262, 2778, 3865, 3873], 'EGF-dependent': [161, 189, 356, 384, 1209, 2473, 2511, 2650], 'signaling.': [162, 357], 'Importantly,': [163, 358], 'inhibition': [166, 361, 1243, 2544, 3732, 3743, 4485, 4808, 4817, 5175, 5239], 'selective,': [168, 363], 'as': [169, 364, 520, 631, 955, 1232, 1633, 1672, 1674, 1721, 1859, 1868, 2972, 2974, 3052, 3375, 3392, 3521, 3751, 4067, 4726, 4749, 4873, 5017, 5180], 'does': [171, 366, 2526, 3231, 4013, 4857], 'not': [172, 367, 2437, 2527, 2786, 2828, 3232, 3417, 3463, 3500, 3537, 4014, 4058, 4563, 4834, 4858, 5035, 5057, 5163, 5181, 5257], 'effect': [173, 368, 5064], 'JNK.': [178, 373], 'results': [180, 375, 2413, 2654, 3245, 3369, 4163, 4364, 4669, 4743, 5082], 'suggest': [181, 376, 1257, 1282, 4164, 4479, 5130], 'selectively': [186, 381, 2876, 4509], 'Cervical': [390], 'cancer': [391, 395, 738, 913, 1000, 3760], 'common': [394], 'among': [396, 5044], 'women': [397], 'worldwide.': [398], 'Human': [399, 5300], 'papillomavirus': [400, 5304], '(HPV)': [401], '1The': [402, 460], 'abbreviations': [403, 461], 'used': [404, 462, 2112, 3388, 3593], 'are:': [405, 463], 'HPV,': [406, 464], 'human': [407, 465, 3631], 'papillomavirus;': [408, 466], 'EGF,': [409, 467, 1360], 'factor;': [412, 470], 'EGF': [414, 472, 2373, 2391, 2635, 3661, 5093], 'receptor;': [415, 473], 'DM,': [416, 474], 'defined': [417, 475, 1324, 1400, 1558, 1569], 'medium;': [418, 476], 'EGCG,': [419, 477, 5230], 'epigallocatechin-3-gallate;': [420, 478], 'FITC,': [421, 479], 'fluorescein': [422, 480], 'isothiocyanate;': [423, 481], 'TUNEL,': [424, 482], 'terminal': [425, 483], 'deoxynucleotidyltransferase-mediated': [426, 484], 'labeling;': [430, 488], 'PARP,': [431, 489], 'poly(ADP-ribose)polymerase;': [432, 490], 'ERK,': [433, 491, 2476, 2644], 'extracellular': [434, 492], 'signal-regulated': [435, 493], 'kinase;': [436, 444, 448, 452, 455, 494, 502, 506, 510, 513], 'PKB,': [437, 495], 'B;': [440, 498], 'MAPK,': [441, 499], 'SAPK,': [445, 503], 'stress-activated': [446, 504], 'JNK,': [449, 507, 2477], 'c-Jun': [450, 508], 'NH2-terminal': [451, 509], 'CDK,': [453, 511], 'cyclin-dependent': [454, 512], 'forkhead': [457, 515, 2797], 'transcription': [458, 516, 2798], 'factor.': [459, 517], 'implicated': [519], 'causative': [522], 'agent': [523, 1290, 5309, 5411], 'genesis': [526, 5312], 'this': [528, 642, 902, 984, 1225, 2419, 3234, 3950, 4054, 5098, 5166, 5271, 5328], 'disease': [529, 964, 3632], '(1Zur': [530], 'H.H.': [531], 'Biochim.': [532, 1084], 'Biophys.': [533, 1085, 1186], 'Acta.': [534, 1086], '1996;': [535], '1288:': [536], 'F55-F78PubMed': [537], 'Google': [538, 585, 620, 661, 681, 703, 729, 759, 778, 804, 836, 855, 888, 899, 938, 1016, 1052, 1069, 1093, 1115, 1140, 1177, 1195, 1655, 1743, 1762, 2344, 2355, 2503, 2572, 2585, 2599, 2632, 2695, 2908, 2936, 3671, 3708, 3719, 3783, 3805, 3834, 3856, 3915, 3929, 3944, 3976, 3990, 4122, 4160, 4204, 4224, 4255, 4289, 4323, 4347, 4417, 4449, 4473, 4538, 4616, 4646, 4783, 4799, 4915, 4937, 4976, 4998, 5363], 'Scholar).': [539, 586, 621, 730, 900, 939, 1017, 1141, 1196, 1656, 1763, 2356, 2504, 2600, 2633, 2696, 2937, 3720, 3857, 3945, 3991, 4161, 4225, 4348, 4474, 4539, 4617, 4647, 4938, 5364], 'High': [540], 'risk': [541, 1001], 'HPV': [542, 5322, 5337], 'subtypes': [543], 'immortalize': [544], 'epithelial': [546], 'cells': [547, 591, 1301, 1306, 1319, 1380, 1396, 1413, 1582, 1615, 1660, 1811, 1836, 1846, 1865, 1899, 1916, 1944, 1970, 1985, 2321, 2365, 2376, 2427, 2469, 2663, 2728, 2814, 2989, 3003, 3045, 3060, 3109, 3157, 3179, 3198, 3211, 3280, 3401, 3408, 3415, 3424, 3437, 3447, 3544, 3624, 3659, 4170, 5209, 5320, 5373], 'via': [548], 'action': [550, 1280, 5334], 'two': [552, 2159], 'oncogenes,': [553], 'E6': [554, 5386], 'E7,': [556, 5345], 'enhance': [558, 4878], 'proliferation': [560, 810, 865, 1378, 2557, 3025, 3138, 3656, 3675, 3762, 3875, 4526], 'by': [561, 989, 1592, 1679, 1849, 2127, 2158, 2194, 2234, 2246, 2307, 2388, 2424, 2439, 2514, 2519, 2721, 2735, 2867, 3121, 3164, 3299, 3523, 3608, 3678, 3876, 4000, 4034, 4182, 4578, 4730, 4751, 4830, 4839, 4848, 5011, 5030, 5226, 5250, 5258, 5321], 'abrogating': [562], 'apoptosis': [563, 603, 3262, 4810], 'cycle': [566, 1158, 1665, 4504], 'checkpoint': [567], 'function': [568, 907], '(2Howley': [569], 'P.M.': [570], 'Munger': [571], 'K.': [572, 785, 3792, 4268, 4528], 'Romanczuk': [573], 'H.': [574, 670, 1184, 4137, 4143, 4394, 4400], 'Scheffner': [575], 'M.': [576, 781, 783, 1058, 1079, 1129, 3788, 3918, 3920, 4314, 4326, 4599, 4634, 4790], 'Huibregtse': [577], 'J.M.': [578, 3820, 4280], 'Princess': [579], 'Takamatsu': [580], 'Symp.': [581], '1991;': [582], '22:': [583, 698, 754, 3778, 4533], '239-248PubMed': [584], 'As': [587, 2755, 2808, 2955, 3014, 3076, 3112, 3143, 3509, 4758, 4939], 'result,': [589], 'HPV-immortalized': [590, 5372], 'acquire': [592], 'mitogenic': [594], 'potential': [595], 'ability': [598, 1204, 3525, 3647], 'resist': [600], 'differentiation': [601, 2613, 4879], '(3Hanahan': [604], 'D.': [605, 1081, 1639, 1727, 4302, 4420, 4462, 4792], 'Weinberg': [606], 'R.A.': [607, 871, 2327, 2486, 2678, 3691], 'Cell.': [608, 1169, 2564, 2900, 3907, 3968, 4110, 4148, 4405, 4638, 4775], '2000;': [609, 1010, 1189, 1649, 1737, 2621, 3802, 3828, 4438, 4532], '100:': [610], '57-70Abstract': [611], 'Full': [612, 614, 655, 880, 882, 1107, 1109, 2336, 2338, 2495, 2497, 2624, 2626, 2687, 2689, 2928, 2930, 3700, 3702, 4114, 4116, 4152, 4154, 4216, 4218, 4409, 4411, 4441, 4443, 4608, 4610, 4907, 4909, 4929, 4931, 4968, 4970, 4990, 4992], 'Text': [613, 615, 656, 881, 883, 1108, 1110, 2337, 2339, 2496, 2498, 2625, 2627, 2688, 2690, 2929, 2931, 3701, 3703, 4115, 4117, 4153, 4155, 4217, 4219, 4410, 4412, 4442, 4444, 4609, 4611, 4908, 4910, 4930, 4932, 4969, 4971, 4991, 4993], 'PDF': [616, 657, 884, 1111, 2340, 2499, 2628, 2691, 2932, 3704, 4118, 4156, 4220, 4413, 4445, 4612, 4911, 4933, 4972, 4994], 'PubMed': [617, 658, 678, 700, 756, 852, 885, 935, 1013, 1066, 1090, 1112, 1137, 1174, 1192, 1652, 1740, 1759, 2341, 2500, 2569, 2582, 2596, 2629, 2692, 2905, 2933, 3705, 3780, 3831, 3853, 3912, 3973, 3987, 4119, 4157, 4201, 4221, 4252, 4286, 4320, 4344, 4414, 4446, 4470, 4535, 4613, 4643, 4780, 4912, 4934, 4973, 4995, 5362], 'Scopus': [618, 659, 679, 701, 757, 853, 886, 936, 1014, 1067, 1091, 1113, 1138, 1175, 1193, 1653, 1741, 1760, 2342, 2501, 2570, 2583, 2597, 2630, 2693, 2906, 2934, 3706, 3781, 3832, 3854, 3913, 3974, 3988, 4120, 4158, 4202, 4222, 4253, 4287, 4321, 4345, 4415, 4447, 4471, 4536, 4614, 4644, 4781, 4913, 4935, 4974, 4996], '(22075)': [619], '(EGFR),': [627], 'referred': [629, 953], 'ErbB1,': [632], 'its': [634, 923, 2609], 'effectors': [636], 'play': [637, 3754], 'key': [639, 3756], 'role': [640, 2610, 3757], 'process': [643], '(4Prigent': [644], 'S.A.': [645], 'Lemoine': [646], 'N.R.': [647], 'Prog.': [648], 'Growth': [649, 3982], 'Factor': [650], 'Res.': [651, 673, 725, 774, 832, 848, 895, 1062, 1187, 1648, 1736, 1755, 2351, 3667, 3715, 3925, 3940], '1992;': [652, 801], '4:': [653], '1-24Abstract': [654], '(317)': [660], 'Scholar,': [662, 682, 704, 760, 779, 837, 889, 1094, 1178, 1744, 2345, 2573, 2586, 2909, 3709, 3784, 3806, 3835, 3916, 3930, 3977, 4205, 4256, 4290, 4324, 4418, 4450, 4784, 4916, 4977], '5Earp': [663], 'H.S.': [664, 2917], 'Dawson': [665], 'T.L.': [666], 'Li': [667, 4457], 'X.': [668, 3790, 4139, 4396], 'Yu': [669], 'Breast': [671], 'Cancer': [672, 724, 773, 831, 894, 1008, 2350, 3666, 3714, 3924, 3939, 4465, 4794], 'Treat.': [674], '1995;': [675, 932, 1756, 2593], '35:': [676], '115-132Crossref': [677], '(353)': [680], '6Ngan': [683], 'H.Y.': [684, 740, 3764], 'Cheung': [685, 741, 3765], 'A.N.': [686, 742, 3766], 'Liu': [687, 743, 3767, 3819, 4453], 'S.S.': [688, 744, 3768], 'Cheng': [689, 745, 1181, 3769, 3846, 4789], 'D.K.': [690, 746, 3770], 'Ng': [691, 747, 3771], 'T.Y.': [692, 748, 3772], 'Wong': [693, 749, 3773], 'L.C.': [694, 750, 3774], 'Tumour': [695, 751, 3775], 'Biol.': [696, 752, 875, 1102, 2331, 2490, 2682, 2923, 3695, 3776, 4436, 4603, 4795, 4924, 4985], '2001;': [697, 753, 833, 1049, 1104, 2902, 3777, 3926, 3970, 4198, 4467], '176-183Crossref': [699, 755, 3779], '(44)': [702, 758, 3782], '7Kersemaekers': [705], 'A.M.': [706, 4920, 4981], 'Fleuren': [707], 'G.J.': [708, 4330], 'Kenter': [709], 'G.G.': [710], 'Van': [711, 719], 'den': [712], 'Broek': [713], 'L.J.': [714], 'Uljee': [715], 'S.M.': [716, 4332], 'Hermans': [717], 'J.': [718, 874, 1007, 1047, 1101, 1168, 2330, 2489, 2592, 2681, 2922, 3694, 3794, 3798, 3800, 3818, 3906, 4107, 4244, 4258, 4260, 4339, 4435, 4602, 4901, 4923, 4962, 4984, 5357], 'de': [720], 'Vijver': [721], 'M.J.': [722, 4095, 4103], 'Clin.': [723, 3923], '1999;': [726, 1171, 4111, 4640], '5:': [727, 4797], '577-586PubMed': [728], 'increase': [735, 1149, 2538, 2952, 3249, 3258, 3284, 3467, 4357, 4691], '(6Ngan': [739, 3763], '8Gullick': [761], 'W.J.': [762], 'Marsden': [763], 'J.J.': [764], 'Whittle': [765], 'N.': [766, 839, 891, 1077, 1180, 1748, 2347, 3663, 3711], 'Ward': [767], 'B.': [768, 1073, 4597], 'Bobrow': [769], 'L.': [770, 830, 2913], 'Waterfield': [771], 'M.D.': [772], '1986;': [775], '46:': [776], '285-292PubMed': [777], '9Ueda': [780], 'Ueki': [782], 'Kitsuki': [784], 'Misaki': [786], 'O.': [787], 'Seiki': [788], 'Y.': [789, 795, 1127, 1131, 4145, 4402], 'Iwai': [790], 'E.': [791, 820, 4278], 'Tsurunaga': [792], 'T.': [793, 1121, 1123, 1125, 4262, 4892, 4918, 4953, 4979], 'Okamoto': [794], 'Nippon': [796], 'Sanka': [797], 'Fujinka': [798], 'Gakkai': [799], 'Zasshi.': [800], '44:': [802], '1165-1172PubMed': [803], 'Scholar),': [805, 856, 1053, 1070, 1116, 4800, 4999], 'along': [806], '(10Akerman': [811], 'G.S.': [812], 'Tolleson': [813], 'W.H.': [814], 'Brown': [815], 'K.L.': [816], 'Zyzak': [817], 'L.L.': [818], 'Mourateva': [819], 'Engin': [821], 'T.S.': [822], 'Basaraba': [823], 'A.': [824, 928, 930, 1005, 2617, 4091, 4093, 4197, 4300, 4310, 4312], 'Coker': [825], 'A.L.': [826, 3847], 'Creek': [827], 'K.E.': [828], 'Pirisi': [829], '61:': [834], '3837-3843PubMed': [835], '11Sizemore': [838], 'Choo': [840, 1640, 1728], 'C.K.': [841, 1641, 1729, 3845], 'Eckert': [842, 868, 1642, 1730, 2324, 2483, 2675, 3688, 4921, 4982], 'R.L.': [843, 869, 1643, 1731, 2325, 2484, 2676, 3689, 4890, 4922, 4951, 4983], 'Rorke': [844, 872, 892, 1751, 2328, 2348, 2487, 2679, 3664, 3692, 3712], 'E.A.': [845, 873, 893, 1637, 1725, 1752, 2329, 2349, 2488, 2680, 3665, 3693, 3713], 'Exp.': [846, 1646, 1734, 1753], 'Cell': [847, 1294, 1297, 1523, 1612, 1647, 1735, 1754, 2266, 2885, 3127, 3452, 3570, 4667], '1998;': [849, 1063, 1134, 5359], '244:': [850], '349-356Crossref': [851], '(45)': [854], 'attenuation': [858], '(12Sah': [866, 2322, 2481, 2673, 3686], 'J.F.': [867, 1056, 2323, 2482, 2674, 3687, 4896, 4957], 'Chandraratna': [870, 2326, 2485, 2677, 3690], 'Chem.': [876, 1103, 2332, 2491, 2683, 2924, 3696, 4437, 4604, 4925, 4986], '2002;': [877, 1087, 2333, 2492, 2566, 2579, 2684, 2925, 3697, 3850, 3941, 3984, 4213, 4249, 4283, 4317, 4341, 4777], '277:': [878, 2334, 2493, 2685, 2926, 3698], '9728-9735Abstract': [879, 2335, 2494, 2686, 3699], '(69)': [887, 1139, 2343, 2502, 2694, 3707, 4615], '13Sizemore': [890, 2346, 3710], '1993;': [896, 2352, 3668, 3716], '53:': [897, 2353, 3669, 3717], '4511-4517PubMed': [898, 2354, 3670, 3718], 'For': [901, 1316, 1377, 1410, 4558], 'reason,': [903], 'interfering': [904], 'focus': [910], 'anti-cervical': [912], 'therapy.': [914], 'Efforts': [915], 'have': [919, 3644, 3652, 4947], 'focused': [920], 'decreasing': [922], 'level': [924, 2435, 2530, 2642, 3287, 3478, 3483, 3488, 3685, 4181, 4232], 'and/or': [925], '(14Levitzki': [927], 'Gazit': [929], 'Science.': [931, 2578], '267:': [933], '1782-1788Crossref': [934], '(1616)': [937], 'addition,': [941, 1143, 3420], 'targets,': [944, 5046], 'B': [950], '(PKB,': [951], 'AKT),': [956], 'considered': [958], 'viable': [959], 'drug': [960], 'targets.': [961], 'Because': [962], 'develops': [965], 'slowly': [966], 'requires': [968, 3660, 5332], 'events,': [970], 'use': [972], 'dietary': [974], 'chemopreventive': [975, 1026, 1289], 'an': [978, 1287, 1840, 2238, 3144, 3257, 3475, 4689, 5150, 5408], 'important': [979, 2607], 'option': [980], 'disease,': [985], 'which': [986, 3557, 3629, 4483, 5007, 5340, 5346], 'supported': [988], 'epidemiologic': [990], 'modifying': [994], 'diet': [996], 'can': [997, 3095, 3863, 4676], 'reduce': [998, 2528], '(15Murthy': [1002], 'N.S.': [1003], 'Mathew': [1004], 'Eur.': [1006], 'Prev.': [1009], '9:': [1011, 2594], '5-14Crossref': [1012], '(50)': [1015], 'Polyphenols': [1018], 'derived': [1019], 'from': [1020, 1416, 1442, 1448, 1456, 1468, 1487, 1522, 1534, 1546, 1695, 2265, 2271, 2726, 4806], 'solids': [1023], 'effective': [1025, 1288, 5409], 'agents.': [1027], '(-)Epigallocatechin-3-gallate': [1028], '(EGCG)': [1029], 'major': [1032, 5307], 'polyphenol': [1034, 1279], 'tea.': [1038], 'It': [1039, 2938], 'possesses': [1040], 'anti-oxidant': [1041], '(16Katiyar': [1042], 'S.K.': [1043], 'Elmets': [1044], 'C.A.': [1045], 'Int.': [1046, 3799], 'Oncol.': [1048, 3801], '18:': [1050], '1307-1313PubMed': [1051], 'anti-mutagenic': [1054], '(17Hernaez': [1055], 'Xu': [1057, 2914], 'Dashwood': [1059], 'R.H.': [1060, 4338], 'Mutat.': [1061], '402:': [1064], '299-306Crossref': [1065], '(52)': [1068], 'anti-proteolytic': [1071], '(18Annabi': [1072], 'Lachambre': [1074], 'M.P.': [1075], 'Bousquet-Gagnon': [1076], 'Page': [1078], 'Gingras': [1080], 'Beliveau': [1082], 'R.': [1083, 2577, 2588, 2919, 4264, 4276], '1542:': [1088], '209-220Crossref': [1089], '(150)': [1092], '19Nam': [1095], 'S.': [1096, 3932, 3934, 4141, 4196, 4272, 4398, 4636, 4894, 4900, 4955, 4961], 'Smith': [1097], 'D.M.': [1098, 3822], 'Dou': [1099], 'Q.P.': [1100], '276:': [1105], '13322-13330Abstract': [1106], '(475)': [1114], 'anti-proliferative': [1118], '(20Otsuka': [1120], 'Ogo': [1122], 'Eto': [1124], 'Asano': [1126], 'Suganuma': [1128], 'Niho': [1130], 'Life': [1132, 1548], 'Sci.': [1133, 2620, 4194, 4212], '63:': [1135, 3851], '1397-1403Crossref': [1136], 'it': [1144, 4856, 5100, 5187, 5214, 5275, 5367], 'has': [1145], 'been': [1146], 'shown': [1147, 2756, 2956, 3015, 3113, 3455, 3510, 3654], 'activity,': [1154, 4495], 'progression': [1159, 4632, 4719], '(21Liang': [1160], 'Y.C.': [1161, 3812, 3843, 3899], 'Lin-Shiau': [1162, 3900], 'S.Y.': [1163, 3901], 'Chen': [1164, 3902], 'C.F.': [1165, 3903], 'Lin': [1166, 3797, 3811, 3904, 4096], 'J.K.': [1167, 3905], 'Biochem.': [1170, 1185, 2619, 3848, 3908, 4211], '75:': [1172], '1-12Crossref': [1173], '(212)': [1176], '22Ahmad': [1179], 'P.': [1182, 4099, 4296, 4308], 'Mukhtar': [1183], 'Commun.': [1188], '275:': [1190, 4439], '328-334Crossref': [1191], '(215)': [1194], 'examined': [1202, 1979, 2714], 'MAPK': [1214, 2252, 2835, 2887], 'activation.': [1215, 3730], 'Our': [1216, 3721, 4540, 5081], 'show': [1218, 3724, 4542, 4670], 'function.': [1223], 'Remarkably,': [1224], 'leads': [1226, 1245, 4488, 4687], 'highly': [1228], 'specific': [1229, 2880], 'effects,': [1231], 'only': [1233, 3993, 5022], 'selected': [1234, 1263, 5023], 'EGFR-responsive': [1236], 'ultimately': [1244], 'cessation': [1248, 4662], 'apoptosis.': [1251, 3398, 4072, 4172], 'vitro': [1254, 2745, 5127, 5202], 'kinases.': [1265, 5242], 'provide': [1268], 'novel': [1269], 'new': [1270], 'insights': [1271], 'into': [1272, 1955, 2200], 'intracellular': [1274, 5078], 'mechanism': [1275, 3150], 'cancer.': [1293, 5315, 5414], 'Culture': [1295], 'Proliferation': [1298], 'Assay—Immortalized': [1299], '(ECE16-1)': [1302], 'tumor': [1305], '(HeLa,': [1307], 'Caski,': [1308], 'SiHa)': [1310], 'were': [1311, 1320, 1381, 1397, 1414, 1440, 1447, 1486, 1520, 1533, 1544, 1552, 1583, 1616, 1703, 1766, 1794, 1812, 1837, 1847, 1857, 1866, 1882, 1900, 1917, 1945, 1971, 1987, 2006, 2046, 2138, 2142, 2150, 2232, 2256, 2274, 2366, 2377, 2724, 2733, 2740, 2990, 3004, 3061, 3119, 3297, 3416, 3438, 3536, 3545, 3560, 3572, 3582, 3606], 'maintained': [1312], 'complete': [1314, 1390], 'medium.': [1315, 1391, 1806], 'experiments,': [1317, 1379], 'treated': [1321, 1403, 1622, 1783, 1909, 2379, 2428, 2991, 3062, 3104, 3155, 3305, 3561], 'medium': [1325, 1401, 1406, 1434, 1559, 1570, 1770], '(DM)': [1326], 'composed': [1327], "Dulbecco's": [1329, 1803], 'modified': [1330, 1428, 1804, 2101, 5010], "Eagle's": [1331, 1429, 1805], 'medium:F12': [1332], '(3:1)': [1333], 'supplemented': [1334, 2216], '1': [1336, 1348, 1572, 1772, 1959, 2063, 2066, 2069, 2075, 2185, 2221, 2287, 2400], 'mg/ml': [1337], 'bovine': [1338, 1438], 'serum': [1339, 1439], 'albumin,': [1340], 'non-essential': [1341], 'amino': [1342], 'acids,': [1343], 'l-glutamine,': [1344], '5': [1345, 2178, 2227, 2389], 'μg/ml': [1346, 1355, 2085], 'transferrin,': [1347], 'nm': [1349, 1352], 'triiodothyronine,': [1350], '0.18': [1351], 'adenine,': [1353], '50': [1354, 1370, 2052, 2072, 2430, 2507, 2995, 3242], 'ascorbic': [1356], 'acid,': [1357, 1599], '20': [1358, 1818, 2218, 2283], 'ng/ml': [1359, 2390], 'antibiotics.': [1362], 'was': [1364, 1454, 1466, 1677, 1693, 1832, 1874, 2022, 2038, 2097, 2111, 2121, 2192, 2299, 2785, 2827, 2839, 2853, 2864, 2939, 2970, 3012, 3041, 3050, 3273, 3472, 3489], 'dissolved': [1365, 1600], 'sterile': [1367], 'water': [1368], 'mm': [1371, 2053, 2058, 2064, 2067, 2070, 2073, 2076, 2080, 2165, 2170, 2173, 2176, 2179, 2182, 2186], 'stored': [1373], '4': [1375, 2133, 2145], '°C.': [1376, 2134], 'plated': [1382, 3546], '24-well': [1384], 'plates': [1385], '10,000': [1387, 1686, 1996], 'cells/well': [1388, 1888], 'Twenty-four': [1392], 'hours': [1393], 'after': [1394, 2977, 4679], 'plating,': [1395], 'equilibrated': [1398], 'EGCG-containing': [1405], 'alternate': [1408], 'days.': [1409], 'counting,': [1411], 'harvested': [1415, 1795], 'triplicate': [1417], 'wells': [1418], 'trypsin': [1420], 'counted': [1422, 1606], 'using': [1423, 1876, 2024, 2040, 2099, 2262, 2301], 'Coulter': [1425], 'counter.': [1426, 1611], "Reagents—Dulbecco's": [1427], 'medium,': [1430, 1433, 3008], "Ham's": [1431], 'F-12': [1432], 'supplements,': [1435], 'fetal': [1437], 'purchased': [1441, 1455, 1521, 1545, 2264], 'Invitrogen.': [1443], 'Epigallocatechin-3-gallate': [1444], 'anti-β-actin': [1446], 'Sigma.': [1449], 'Histone': [1450], 'H1': [1451, 3528], 'pRB': [1453, 3464], 'Upstate': [1457], 'Biotechnology': [1458, 1490], '(Lake': [1459], 'Placid,': [1460], 'NY).': [1461, 1880], 'Anti-activated': [1462], 'antibody': [1464, 2021, 2029, 2120, 2305], '(E12120)': [1465], 'obtained': [1467], 'Translab,': [1469], 'anti-phosho-ERK1/2': [1470], '(K-23),': [1471], 'anti-ERK1/2': [1472], '(E-4),': [1473], 'anti-CDK2': [1474], '(M-2),': [1475], 'anti-CDK4': [1476], '(H-22),': [1477], 'anti-CDK6': [1478], '(H-230),': [1479], 'anti-cyclin': [1480], '(M-20),': [1482], 'anti-EGFR': [1484], '(1005)': [1485], 'Santa': [1488], 'Cruz': [1489], '(Santa': [1491], 'Cruz,': [1492], 'CA).': [1493, 1538], 'Anti-AKT': [1494], '(9272),': [1495], 'anti-p38': [1496], '(9212),': [1497], 'anti-SAPK/JNK': [1498], '(9252),': [1499], 'anti-phospho-AKT': [1500], '(9271),': [1501], 'anti-phospho-p38': [1502], '(9211),': [1503], 'anti-phospho-ATF-2': [1504], '(9225),': [1505], 'anti-phospho-ELK-1': [1506], '(9181),': [1507], 'anti-phospho-GSK3': [1508], 'α/β': [1509], '(9331),': [1510], 'anti-phospho-BAD': [1511], '(9291),': [1512], 'anti-phospho-FKHR': [1513], '(9461),': [1514], 'anti-phospho-p90RSK': [1515], '(9344),': [1516], 'anti-phospho-SAPK/JNK': [1518], '(9251)': [1519], 'Signaling': [1524, 2267], 'Technologies': [1525], '(Beverley,': [1526], 'MA).': [1527], 'Anti-cyclin': [1528], 'D1,': [1529], 'anti-p53,': [1530], 'anti-pRB': [1532], 'Pharmingen': [1535], '(San': [1536], 'Diego,': [1537], 'Anti-PARP,': [1539], 'anti-p21WAF-1,': [1540], 'anti-p27KIP-1,': [1541], '[γ-32P]ATP': [1543], 'PerkinElmer': [1547], 'Sciences.': [1549], 'Thymidine': [1550], 'Incorporation—Cells': [1551], 'grown': [1553], '24': [1555, 1905, 2671, 3064, 3174, 3568], 'h': [1556, 1906, 1960, 2131, 2672, 2976, 3065, 3175, 3188, 3312], 'containing': [1560, 1571, 2051], 'various': [1561, 2730, 3563], 'concentrations': [1562, 2761, 2777, 2844, 3225, 3564], 'then': [1566, 1782, 1824, 1908, 1918, 1972, 2378, 2741, 3069, 3161], 'shifted': [1567], 'μCi': [1573, 2228], '[3H]thymidine': [1575, 3072, 3088], '(61': [1576], 'Ci/mmol)/ml': [1577], '2': [1579, 1602, 2079, 2130], 'h.': [1580, 1792, 1914, 3569], 'thoroughly': [1584], 'washed': [1585, 1798, 1825, 1923, 1965, 2151], "Hanks'": [1587], 'balanced': [1588], 'salt': [1589], 'solution': [1590, 1950], 'followed': [1591, 2126, 2157, 2245, 2306, 2387], 'single': [1594, 1716], 'wash': [1595], '5%': [1597], 'trichloroacetic': [1598], 'n': [1603], 'NaOH,': [1604], 'liquid': [1609], 'scintillation': [1610], 'Cycle': [1613, 3453], 'Analysis—EGCG-treated': [1614], 'harvested,': [1617], 'fixed': [1618, 1919], 'methanol,': [1620], 'washed,': [1621], 'RNase': [1624], 'A,': [1625, 2090], 'stained': [1627, 1864, 3314], 'DNA': [1629, 1683, 1948, 3048], 'propidium': [1631, 3213, 3253, 3320, 3328, 3350, 4701], 'iodide': [1632, 1831, 3321, 3351], 'described': [1634, 1722], 'previously': [1635, 1723, 3653], '(23Rorke': [1636, 1724], 'Zhang': [1638, 1726, 4596], 'Jacobberger': [1644, 1732], 'J.W.': [1645, 1733, 1746], '259:': [1650, 1738], '149-157Crossref': [1651, 1739], '(36)': [1654, 1742], 'fraction': [1658], 'each': [1663, 2086, 2124], 'phase': [1666], '(G0/G1,': [1667], 'S,': [1668], 'G2': [1669, 1711], '+': [1670, 1712], 'M),': [1671], 'well': [1673], 'cells,': [1676, 3255, 3304, 3628, 4567, 4703], 'determined': [1678, 2300], 'mathematical': [1680], 'modeling': [1681, 1691], 'histograms': [1684], 'representing': [1685], 'events': [1687], 'or': [1688, 2646, 2951, 2993, 3139, 3218, 3682, 5143], 'more.': [1689], 'software': [1692], 'Modfit': [1694], 'Verity': [1696], 'House': [1697], '(Topsham,': [1698], 'ME).': [1699], 'model': [1701], 'components': [1702], 'based': [1704], 'normal': [1706, 5318], 'distributions': [1707], 'Go/G1': [1709], 'M': [1713], 'broadened': [1717], 'trapezoid': [1718], 'S-phase': [1720, 4631], '24Jacobberger': [1745], 'Sizemore': [1747], 'Gorodeski': [1749], 'G.': [1750, 4292, 4306], '220:': [1757], '390-396Crossref': [1758], '(14)': [1761], 'Apoptosis': [1764], 'Assay—Cells': [1765], 'seeded': [1767, 1883], '×': [1773, 1886], '105': [1774], 'cells/35-mm': [1775], 'dish,': [1776], 'allowed': [1777, 1894, 3551], 'attach': [1779, 1896], 'overnight,': [1780], '5–50': [1785], 'μm': [1786, 2382, 2431, 2508, 2753, 2996, 3230, 3243, 3308], 'DM': [1789, 1903], '0–48': [1791, 1913], 'Cells': [1793, 1852, 1881, 3323, 3343], 'trypsin,': [1797], 'once,': [1799], 'resuspended': [1801], 'To': [1807, 2357, 2981, 3090], 'detect': [1808], 'annexin': [1809, 1815, 3206, 3271, 3300, 3317, 3348], 'V,': [1810], 'incubated': [1813, 1838, 1946, 2013, 2212, 2275, 2742], 'V-FITC': [1816, 3301], 'min': [1819, 2278, 2386, 2669], '37': [1821, 1962], '°C': [1822, 1963, 2146, 2281], 'remove': [1827], 'unbound': [1828], 'annexin.': [1829], 'Propidium': [1830], 'added,': [1833, 2139], 'additional': [1841, 5000], '30': [1842, 2277, 2280, 2385, 3240], 'min.': [1843, 2394], 'labeled': [1845], 'analyzed': [1848, 3162], 'cytometry.': [1851, 3166], 'showed': [1854], 'FITC': [1855], 'designated': [1858, 1867], 'apoptotic,': [1860], 'whereas': [1861, 4124, 5037], 'double': [1863], 'post-apoptotic.': [1869], 'Assay—A': [1871], 'assay': [1873, 3391, 5203], 'performed': [1875, 2039], 'ApopTag': [1877], '(Intergen,': [1878], 'Purchase,': [1879], '1–4': [1885], '104': [1887], '12-well': [1890], 'cluster': [1891], 'dishes': [1892, 3549], 'overnight.': [1897, 2147], 'switched': [1901], '1%': [1921, 2060], 'paraformaldehyde,': [1922], 'phosphate-buffered': [1925, 1941], 'saline,': [1926, 1942], 'permeabilized': [1928], 'pre-chilled': [1930], '(-20': [1931], '°C)': [1932], 'ethanol:acetic': [1933], 'acid': [1934], '(2:1': [1935], 'v/v).': [1936], 'After': [1937, 2998], 'further': [1938], 'washing': [1939], 'labeling': [1949], '(enzymatic': [1951], 'incorporation': [1952, 2196], 'FITC-UTP': [1954], 'stand': [1956], 'breaks)': [1957], 'stop/wash': [1967], 'buffer.': [1968], 'mounted': [1973], 'Anti-Fade®': [1975], '(Molecular': [1976], 'Probes)': [1977], 'fluorescence': [1982], 'microscope.': [1983], 'Immunoblot—Total': [1984], 'extracts': [1986], 'prepared': [1988, 2725], 'Laemmli': [1990, 2243], 'sample': [1991, 2125, 3613], 'buffer': [1992, 2050, 2156, 2163, 2215, 2244], 'electrophoresed': [1994], 'equivalents/lane': [1998], 'denaturing': [2000], 'acrylamide': [2001], 'gels.': [2002], 'separated': [2004], 'proteins': [2005], 'transferred': [2007, 3005], 'polyvinylidene': [2009], 'difluoride': [2010], 'membranes': [2011], 'primary': [2015, 2020, 2119], 'antibody.': [2016], 'Binding': [2017], 'detected': [2023, 2971, 3298], 'horseradish': [2026], 'peroxidase-conjugated': [2027], 'secondary': [2028], 'chemiluminescent': [2031, 2308], 'substrate': [2032, 2298, 3601], '(West': [2033], 'Pico,': [2034], 'Pierce).': [2035], 'Densitometric': [2036], 'analysis': [2037], 'Bio-Rad': [2042], 'FluorS.': [2043], 'Kinase': [2044, 4828], 'Immunoprecipitation—Cells': [2045], 'lysed': [2047], 'Tris,': [2054], 'pH': [2055, 2167], '7.5,': [2056, 2168], '150': [2057], 'NaCl,': [2059], 'Nonidet': [2061], 'P-40,': [2062], 'EDTA,': [2065], 'EGTA,': [2068, 2174], 'β-glycerophosphate,': [2071, 2180], 'NaF,': [2074], 'sodium': [2077, 2183], 'orthovanadate,': [2078, 2184], 'phenylmethylsulfonyl': [2081], 'fluoride,': [2082], '10': [2084, 2169, 2393, 2668, 3229], 'aprotinin,': [2087], 'bestatin,': [2088], 'pepstatin': [2089], 'leupeptin,': [2091], 'E64.': [2093], 'Following': [2094], 'lysis,': [2095], 'estimated': [2098], 'Folin-Lowry': [2102], 'protocol': [2103], '(Bio-Rad),': [2104], '250': [2106], 'μg': [2107, 2222, 2288, 3586], 'lysate': [2110], 'per': [2113], 'reaction.': [2115], 'One': [2116], 'microgram': [2117], 'added': [2122], 'incubation': [2128, 5139], 'Protein': [2135, 2790], 'A/G': [2136, 2209], 'beads': [2137, 2149, 2210, 2270], 'samples': [2141], 'rotated': [2143], 'four': [2152, 4941], 'times': [2153], 'lysis': [2155], 'washes': [2160], '(50': [2164], 'Hepes,': [2166], 'MgCI2,': [2171], '2.5': [2172], 'I': [2175], 'dithiothreitol,': [2177], '0.1': [2181], 'NaF).': [2187], 'Cyclin-dependent': [2188], 'measured': [2193, 2257, 3506, 3522], '[32': [2198], 'P]ATP': [2199], 'substrate.': [2202], 'immunoprecipitated': [2204, 3583], 'bound': [2206], 'pm': [2219, 2284], 'ATP,': [2220], 'substrate,': [2225, 2291], '[γ-32P]ATP.': [2230], 'Reactions': [2231], 'stopped': [2233, 3607], 'equal': [2239], 'volume': [2240], '2×': [2242], 'SDS-PAGE': [2247, 3612], 'exposure': [2249], 'film.': [2251], 'ATK': [2254], 'activities': [2255], 'nonradioactive': [2259], 'assays': [2261, 3596, 5129], 'kits': [2263], 'Technologies.': [2268], 'Washed': [2269], 'immunoprecipitation': [2273], 'ATP': [2285], 'extent': [2294], 'appropriate': [2303, 3599], 'phospho-specific': [2304], 'detection.': [2309], 'Inhibits': [2311, 2708, 2789, 2884], 'Activation—EGFR': [2313], 'ECE16-1': [2320, 2364, 2468, 2662, 2966, 3059, 3156, 3210, 3303, 3400, 3414, 3423, 3543, 3623], 'determine': [2358, 2944, 3091], 'whether': [2359, 2454, 2715, 2945, 3092], 'function,': [2363], 'cultured': [2367], 'overnight': [2368], 'absence': [2371], 'stimulation.': [2374], '0–50': [2381, 2752, 3307], 'upper': [2396, 3358], 'panel': [2397], 'Fig.': [2399, 2758, 2811, 2958, 3017, 3115, 3167, 3457, 3512], 'shows': [2401, 3169], 'marked': [2403, 3248], '(P-EGFR)': [2407], 'EGF-treated': [2409], 'concentration-dependent': [2416, 2963, 3085, 5152], 'Activity': [2421, 4506, 4829], '65%': [2425], 'EGCG.': [2432, 2722, 2754, 2997, 3111, 4840, 4849, 5031], 'Total': [2433], 'affected': [2438], '(Fig.': [2442, 2521, 2648, 2845, 2869, 3207, 3263, 3281, 3409, 3448, 3484, 3502], '1).': [2443], 'Suppresses': [2445], 'Activation': [2447], 'ERK1/2,': [2449, 3955], 'AKT—We': [2451], 'next': [2452, 2713], 'evaluated': [2453], 'down-stream': [2465], 'display': [2470], 'characteristic': [2472], 'p38,': [2478, 2645, 3956], 'Treatment': [2505, 2883, 3125, 3223], '83%': [2515], '50%': [2520], '2).': [2522, 2649], 'contrast,': [2524, 2782, 2824, 3237, 3412, 3531, 4005], 'P-JNK1/2': [2529], '(not': [2531, 2704, 3046], 'shown),': [2532], 'produces': [2535, 3083, 4369], 'slight': [2537], 'p38': [2540, 2604, 2779, 2834, 4006, 4844, 4863, 4874, 4942, 5154], 'selective': [2543], 'noteworthy': [2551, 5189], 'because': [2552], 'regulate': [2555, 4071], 'survival': [2559, 4523, 4770], '(25Nicholson': [2560, 4771], 'K.M.': [2561, 4772], 'Anderson': [2562, 4102, 4773], 'N.G.': [2563, 4774], 'Signal.': [2565, 2901, 3969, 4776], '14:': [2567, 4778], '381-395Crossref': [2568, 4779], '(1373)': [2571, 4782], '26Johnson': [2574], 'G.L.': [2575], 'Lapadat': [2576], '298:': [2580], '1911-1912Crossref': [2581], '(3467)': [2584], '27Seger': [2587], 'Krebs': [2589], 'E.G.': [2590], 'FASEB': [2591], '726-735Crossref': [2595], '(3192)': [2598], 'given': [2608], '(28Nebreda': [2614], 'A.R.': [2615], 'Porras': [2616], 'Trends': [2618, 4210], '25:': [2622], '257-260Abstract': [2623], '(496)': [2631], 'Neither': [2634, 4841], 'nor': [2636, 4843], 'altered': [2639, 4510], 'absolute': [2641], 'biphasic': [2657], 'peak': [2665], 'inhibited': [2698, 2866, 3120, 3677, 3999, 4390, 4838, 4847, 5249], 'both': [2699, 3221, 3347], 'peaks': [2700], 'shown).': [2705, 3047], 'Directly': [2707], 'Activity—We': [2712], 'effected': [2720], 'Extracts': [2723], 'EGF-stimulated': [2727], 'collected': [2734], 'immunoprecipitation.': [2736], 'precipitated': [2738], 'reactions': [2747, 3605], 'presence': [2750], '3,': [2759], 'low': [2760], '(5': [2764], 'μm)': [2765], 'substantial': [2768], 'Higher': [2775], 'MAPK.': [2780], 'JNK1/2': [2783, 4011, 4842, 4850, 5160], 'altered.': [2787, 2830], 'Phosphorylation': [2791, 2831, 2847], 'Downstream': [2792], 'AKT—AKT': [2794], 'targets': [2795, 3963, 4024, 4038, 4554, 5024], 'factor,': [2799], 'BCL-2': [2802], 'family': [2803], 'member': [2804], 'BAD,': [2805], 'GSK3α/β.': [2807], 'seen': [2809, 3077], '4A,': [2812], 'treating': [2813], 'FKHR': [2819, 4068, 4074, 5047], 'BAD': [2821, 4070, 4126, 4494, 5049], 'phosphorylation.': [2822], 'GSK3α/β': [2825, 5054], 'significantly': [2829], 'target,': [2837, 2852, 2862, 4573], 'ATF-2,': [2838], 'enhanced': [2840, 3429, 4866], 'intermediate': [2842], '4B).': [2846], 'ELK,': [2849], 'slightly': [2854, 4008], 'reduced.': [2855, 4547], 'However,': [2856, 3992, 4045, 4548, 4683, 5125, 5243, 5389], 'markedly': [2865, 4576, 5041], '4C).': [2870], 'findings': [2872, 4350, 4478, 4714, 5265], 'indicate': [2873, 4365, 5083], 'substrates.': [2881], 'Proliferation—Reduced': [2886], 'PKB/Akt': [2889], 'frequently': [2892], 'numbers': [2897, 3130, 4697], '(29Liebmann': [2898, 3966], 'C.': [2899, 3786, 3967, 4274], '13:': [2903, 3971], '777-785Crossref': [2904, 3972], '(249)': [2907, 3975], '30Golubovskaya': [2910], 'V.': [2911], 'Beviglia': [2912], 'L.H.': [2915], 'Earp': [2916], 'Craven': [2918], 'Cance': [2920], 'W.': [2921], '38978-38987Abstract': [2927], '(131)': [2935], 'therefore': [2940], 'interest': [2942], 'would': [2947, 5101, 5368], 'suppress': [2948], '5A,': [2959], 'produced': [2961], 'number': [2968], 'early': [2973, 3340], '36': [2975], 'initiation': [2978], 'treatment.': [2980, 3123, 4036, 4580, 4682, 4868], 'assess': [2982], 'reversibility': [2984], 'response,': [2988], 'without': [2994], '48-h': [3000], 'treatment,': [3001], 'EGCG-free': [3007], 'continued.': [3013], '5B,': [3018], 'removal': [3020], 'restores': [3023], 'rate': [3028], 'similar': [3029, 3037], 'observed': [3032, 3042, 3275, 3440, 4385], 'untreated': [3034, 3413], 'cultures.': [3035], 'A': [3036], 'pattern': [3038], 'recovery': [3040], 'HeLa': [3044, 3277], 'synthesis': [3049], 'monitored': [3051], 'second': [3054], 'index': [3055], 'pulsed': [3070], 'prior': [3073], 'harvest.': [3075], 'Fig': [3079], '5C,': [3080], 'decrease': [3086], 'incorporation.': [3089], 'generalized': [3097], 'other': [3099, 3896], 'lines,': [3102], 'HeLa,': [3105, 3444], 'CaSki,': [3106, 3443], 'SiHa': [3108, 3279, 3446], '5D,': [3116], 'all': [3117, 3961, 4835, 5182, 5294], 'lines': [3118], 'Increases': [3126], 'Death—Reduced': [3128], 'could': [3131], 'result': [3134, 5290], 'diminished': [3136, 3480], 'initial': [3145, 5089, 5284, 5325], 'approach': [3146], 'identifying': [3148], 'death,': [3153], 'them': [3163], '6': [3168], 'causes': [3176, 3189], 'accumulation': [3177, 3190, 3195, 3203], '48': [3185, 3311], '72': [3187], 'sub-G1': [3192, 3197, 4693], 'surface': [3205, 4881], '7).': [3208], 'Untreated': [3209], 'iodide-positive': [3214, 3254, 4702], '(4–8%),': [3215], 'annexin-positive': [3216, 3326, 3377], '(1–3%),': [3217], 'positive': [3219, 3345], '(4–10%).': [3222], '≤': [3228], 'alter': [3233], 'distribution.': [3235], 'annexin-': [3251, 4699], 'indicating': [3256], 'advanced': [3260], 'stage': [3261], '7,': [3264], 'C': [3265], 'D).': [3267], 'induction': [3269], 'binding': [3272], '7E).Fig.': [3282], '7EGCG-dependent': [3283], 'phosphatidylserine': [3286, 3295], 'outer': [3290], 'plasma': [3291], 'membrane': [3292], 'leaflet.': [3293], 'A–D,': [3294], 'binding.': [3302], 'FITC-conjugated': [3316], 'V': [3318], '(PI).': [3322], 'iodide-negative': [3329], '(upper': [3330], 'left': [3331], 'corner': [3332], 'lower': [3334], 'right': [3335, 3359], 'quadrant)': [3336, 3360], 'representative': [3338], 'strongly': [3344, 4032], '(above': [3352], 'diagonal': [3354], 'axis': [3355], 'late': [3362], 'apoptotic/necrotic': [3363], 'E,': [3365], 'summary': [3366], 'dot-plot': [3368], 'five': [3371], 'independent': [3372], 'experiments': [3373, 3859], 'expressed': [3374], 'percent': [3376], 'cells.View': [3378], 'Large': [3379, 3615], 'Image': [3380, 3616], 'Figure': [3381, 3617], 'ViewerDownload': [3382, 3618], 'Hi-res': [3383, 3619], 'image': [3384, 3620], 'Download': [3385, 3621], '(PPT)': [3386, 3622], 'We': [3387, 3504, 3651], 'third': [3394], 'method': [3395], 'evaluating': [3397], 'Staining': [3399], 'following': [3402, 4867], 'numerous': [3406], 'TUNEL-positive': [3407, 3436], '8A).': [3410], 'stained.': [3418], 'resulted': [3427], 'cleaved': [3432], '(89': [3433], 'kDa)': [3434], 'PARP.': [3435], 'EGCG-treated': [3442, 4566], '8B).': [3449], 'Perturbs': [3451], 'Regulators—As': [3454], '9B,': [3458], 'increases': [3460, 4080, 5347, 5395], 'p53': [3461, 3469, 4180, 4358, 4371, 4375, 4499, 5342], 'but': [3462, 3492, 4568, 5053, 5159, 5256], 'level.': [3465], 'expression': [3471, 4081, 4186, 4388, 4626, 5350], 'p21WAF-1': [3477], '9A).': [3485, 3503], 'p27': [3487, 4231, 4360, 4377], 'increased,': [3491], 'CDK2,': [3493], 'CDK4,': [3494, 3579], 'D1': [3497], 'did': [3499], 'change': [3501], 'CDK': [3507, 5396], '10,': [3513], 'phosphorylate': [3527], 'histone.': [3529], 'CDK4': [3532], 'CDK6': [3534], 'changed.Fig.': [3538], '10EGCG': [3539], '100-mm': [3548], 'reach': [3553], '60–70%': [3554], 'confluence,': [3555], 'time': [3558], 'they': [3559, 3635], 'lysates': [3571], 'prepared,': [3573], 'indicated': [3576], '(CDK2,': [3578], 'CDK6)': [3581], '(IP)': [3584], '(500': [3585], 'equivalents': [3589], 'lysate/reaction)': [3591], 'ATP.': [3603], 'buffer.View': [3614], 'immortalized': [3626], 'mimic': [3630], 'over-express': [3636], 'grow': [3638], 'fast': [3641], 'rate,': [3642], 'lost': [3645], 'terminally': [3649], 'differentiate.': [3650], '(13Sizemore': [3662], 'Scholar)': [3672], 'blocking': [3679], 'reducing': [3683], 'EGF-mediated': [3728], 'AKT.': [3741], 'significant,': [3750], '31Page': [3785], 'Huang': [3787], 'Jin': [3789], 'Cho': [3791], 'Lilja': [3793], 'Reynolds': [3795], 'R.K.': [3796, 4530], '17:': [3803], '23-28PubMed': [3804], '32Ma': [3807], 'Y.Y.': [3808], 'Wei': [3809], 'S.J.': [3810], 'Lung': [3813], 'J.C.': [3814], 'Chang': [3815], 'T.C.': [3816], 'Whang-Peng': [3817], 'Yang': [3821, 3823, 4461], 'W.K.': [3824], 'Shen': [3825], 'C.Y.': [3826], 'Oncogene.': [3827], '19:': [3829], '2739-2744Crossref': [3830], '(391)': [3833], '33Yeh': [3836], 'P.Y.': [3837], 'Chuang': [3838], 'S.E.': [3839], 'Yeh': [3840], 'K.H.': [3841], 'Song': [3842], 'Ea': [3844], 'Pharmacol.': [3849], '1423-1430Crossref': [3852], '(128)': [3855], 'Cell-free': [3858], 'demonstrate': [3860, 4176], 'Thus,': [3870, 5213], 'direct': [3877, 5238], 'interaction': [3878], 'cascade.': [3887, 4514, 5095], 'suggestion': [3889], 'consistent': [3891], 'recent': [3893], 'reports': [3894, 4174], 'systems': [3897], '(34Liang': [3898], '1997;': [3909, 4149, 4406], '67:': [3910], '55-65Crossref': [3911], '(290)': [3914], '35Masuda': [3917], 'Suzui': [3919], 'Weinstein': [3921], 'I.B.': [3922], '7:': [3927], '4220-4229PubMed': [3928], '36Pianetti': [3931], 'Guo': [3933], 'Kavanagh': [3935], 'K.T.': [3936], 'Sonenshein': [3937], 'G.E.': [3938], '62:': [3942], '652-655PubMed': [3943], 'An': [3946], 'interesting': [3947], 'feature': [3948], 'regulation': [3951, 5133], 'selectivity.': [3954], 'JNK1/2,': [3957], 'AKT/PKB': [3959, 3996, 4029, 4761, 4822, 5045, 5144, 5220], 'known': [3962, 4876, 4945], '37Danielsen': [3978], 'A.J.': [3979], 'Maihle': [3980], 'N.J.': [3981], 'Factors.': [3983], '20:': [3985], '1-15Crossref': [3986], '(91)': [3989], 'vivo.': [4003], 'activated,': [4009], 'change.': [4015], 'particular,': [4017], 'several': [4020], 'pathways': [4030], 'suppressed': [4033, 5029], 'include': [4039], 'AKT/PKB,': [4041, 4491], 'vivo': [4048], 'another': [4051, 4571], 'cascade,': [4055], 'GSK3α/β,': [4056], 'affected.': [4059], 'selectivity': [4061], 'likely': [4063], 'important,': [4066, 4872], 'Dephosphorylated': [4073], 'translocates': [4075], 'nucleus': [4078], 'BIM': [4083], 'FAS': [4085], 'ligand': [4086], '(both': [4087], 'proapoptotic': [4088], 'regulators': [4089, 4623], '(38Brunet': [4090], 'Bonni': [4092], 'Zigmond': [4094], 'M.Z.': [4097], 'Juo': [4098], 'Hu': [4100], 'L.S.': [4101], 'Arden': [4104], 'K.C.': [4105], 'Blenis': [4106], 'Greenberg': [4108, 4146, 4403], 'M.E.': [4109, 4147, 4404], '96:': [4112], '857-868Abstract': [4113], '(5381)': [4121], 'Scholar)),': [4123], 'dephosphorylated': [4125], 'sequesters': [4127], 'inactivates': [4129], 'anti-apoptotic': [4131], 'BCL-XL': [4133], '(39Datta': [4134, 4391], 'S.R.': [4135, 4392], 'Dudek': [4136, 4393], 'Tao': [4138, 4395], 'Masters': [4140, 4397], 'Fu': [4142, 4399], 'Gotoh': [4144, 4401], '91:': [4150, 4407], '231-241Abstract': [4151, 4408], '(4920)': [4159, 4416], 'predisposes': [4168], 'Recent': [4173], 'influences': [4179], 'altering': [4183], 'nuclear': [4184], 'mdm2': [4185], '(40Mayo': [4187], 'L.D.': [4188, 4207], 'Donner': [4189, 4208], 'D.B.': [4190, 4209], 'Proc.': [4191], 'Natl.': [4192], 'Acad.': [4193], 'U.': [4195], '98:': [4199], '11598-11603Crossref': [4200], '(946)': [4203], '41Mayo': [4206], '27:': [4214], '462-467Abstract': [4215], '(351)': [4223], 'Moreover': [4226], 'decreases': [4229], '(42Shin': [4233], 'I.': [4234], 'Yakes': [4235], 'F.M.': [4236], 'Rojo': [4237], 'F.': [4238, 4304, 4898, 4959], 'Shin': [4239], 'N.Y.': [4240], 'Bakin': [4241], 'A.V.': [4242], 'Baselga': [4243], 'Arteaga': [4245, 4433], 'C.L.': [4246, 4434], 'Nat.': [4247, 4281, 4315], 'Med.': [4248, 4282, 4316], '8:': [4250, 4284, 4318], '1145-1152Crossref': [4251], '(681)': [4254], '43Liang': [4257], 'Zubovitz': [4259], 'Petrocelli': [4261], 'Kotchetkov': [4263], 'Connor': [4265], 'M.K.': [4266], 'Han': [4267], 'Lee': [4269], 'J.H.': [4270], 'Ciarallo': [4271], 'Catzavelos': [4273], 'Beniston': [4275], 'Franssen': [4277], 'Slingerland': [4279], '1153-1160Crossref': [4285], '(803)': [4288], '44Viglietto': [4291], 'Motti': [4293], 'M.L.': [4294], 'Bruni': [4295], 'Melillo': [4297], 'R.M.': [4298], "D'Alessio": [4299], 'Califano': [4301], 'Vinci': [4303], 'Chiappetta': [4305], 'Tsichlis': [4307], 'Bellacosa': [4309], 'Fusco': [4311], 'Santoro': [4313], '1136-1144Crossref': [4319], '(603)': [4322], '45Stahl': [4325], 'Dijkers': [4327], 'P.F.': [4328], 'Kops': [4329], 'Lens': [4331], 'Coffer': [4333], 'P.J.': [4334], 'Burgering': [4335], 'B.M.': [4336], 'Medema': [4337], 'Immunol.': [4340], '168:': [4342], '5024-5031Crossref': [4343], '(518)': [4346], 'predict': [4351], 'should': [4356], 'levels.': [4361], 'Indeed,': [4362], 'our': [4363, 5014], 'p27.': [4373], 'Increased': [4374], 'arrest': [4384], 'when': [4386], '46Busse': [4419], 'Doughty': [4421], 'R.S.': [4422], 'Ramsey': [4423], 'T.T.': [4424], 'Russell': [4425], 'W.E.': [4426], 'Price': [4427], 'J.O.': [4428], 'Flanagan': [4429], 'W.M.': [4430], 'Shawver': [4431], 'L.K.': [4432], '6987-6995Abstract': [4440], '(196)': [4448], '47Zhu': [4451], 'X.F.': [4452], 'Z.C.': [4454], 'Xie': [4455], 'B.F.': [4456], 'Z.M.': [4458], 'Feng': [4459], 'G.K.': [4460], 'Zeng': [4463], 'Y.X.': [4464], 'Lett.': [4466], '169:': [4468], '27-32Crossref': [4469], '(96)': [4472], 'On': [4475], 'balance,': [4476], 'pathway': [4481], 'p27,': [4501, 4735], 'Sustained': [4515], 'necessary': [4520], '(48Roovers': [4527], 'Assoian': [4529], 'BioEssays.': [4531], '818-826Crossref': [4534], '(423)': [4537], 'differentially': [4556], 'regulated.': [4557, 5058], 'example,': [4559, 4729], 'ELK1': [4560, 5032], 'changed': [4564], 'p90RSK': [4581, 4656, 5038], 'phosphorylates': [4582], 'transcriptional': [4584, 4622], 'co-activators': [4585], 'p300': [4586], 'CBP': [4588], '(cAMP-response': [4589], 'element-binding': [4590], '(CREB)-binding': [4592], 'protein)': [4593], '(49Wang': [4594], 'Z.': [4595], 'Wang': [4598], 'Carr': [4600], 'B.I.': [4601], '2003;': [4605, 4904, 4926, 4965, 4987], '278:': [4606, 4927, 4988], '11138-11144Abstract': [4607], 'acetyltransferases': [4619], 'associate': [4620], 'promote': [4625], 'genes': [4628], '(50Frodin': [4633], 'Gammeltoft': [4635], 'Mol.': [4637], 'Endocrinol.': [4639], '151:': [4641], '65-77Crossref': [4642], '(615)': [4645], 'Based': [4648, 5096], 'functions,': [4651], 'propose': [4653], 'contribute': [4659, 4885], 'Proliferation/Apoptosis—Our': [4668], 'reversed': [4678], 'short': [4680], 'term': [4681, 4685], 'long': [4684], 'irreversible': [4690, 4746], 'numbers,': [4695], 'staining,': [4706, 4754], 'caspase': [4709], 'PARP': [4711, 4755], 'cleavage.': [4712], 'argue': [4715], 'temporal': [4718], 'wherein': [4720], 'initially': [4722], 'reversibly': [4723], 'proliferation,': [4725], 'manifested,': [4727], 'p21,': [4734], 'prolonged': [4740], 'commitment': [4748], 'evidenced': [4750], 'cleavage,': [4756], 'etc.': [4757], 'reported': [4764], '51Cobb': [4785], 'M.H.': [4786], 'Hepler': [4787], 'J.E.': [4788], 'Robbins': [4791], 'Semin.': [4793], '1994;': [4796], '261-268PubMed': [4798], 'hypothesized': [4802], 'transition': [4805], 'due': [4812, 5118, 5381], 'cascades.': [4824], 'Selective': [4825], 'Inhibition': [4826], 'EGCG—As': [4831], 'noted': [4832, 5018], 'above,': [4833, 5019], 'remains': [4852], 'unchanged,': [4853], 'mediate': [4859], 'EGCG-associated': [4861], 'responses.': [4862, 5296], 'somewhat': [4865], 'epithelia': [4882], 'death': [4888], '(52Eckert': [4889, 4950], 'Efimova': [4891, 4952], 'Balasubramanian': [4893, 4954], 'Crish': [4895, 4956], 'Bone': [4897, 4958], 'Dashti': [4899, 4960], 'Investig.': [4902, 4963], 'Dermatol.': [4903, 4964], '120:': [4905, 4966], '823-828Abstract': [4906, 4967], '(84)': [4914, 4975], '53Efimova': [4917, 4978], 'Broome': [4919, 4980], '34277-34285Abstract': [4928, 4989], '(127)': [4936, 4997], 'isoforms': [4943], 'differential': [4948], 'will': [5002, 5289], 'identify': [5006], 'form': [5008], 'system.': [5015], 'regulated,': [5036], 'suppressed.': [5042], 'Likewise,': [5043], 'suppressed,': [5052], 'net': [5063], 'integration': [5070], 'complex': [5073], 'set': [5074], 'finding,': [5099], 'logical': [5103], 'assume': [5105, 5279], 'solely': [5117], 'more': [5136], 'complex.': [5137], 'Direct': [5138], 'activated': [5141], 'manner.': [5153], 'reduced,': [5158], 'regulated': [5164], 'type': [5167], 'assay.': [5169], 'suggests,': [5171], 'first,': [5172], 'specific,': [5179], 'inhibited.': [5185], 'Second,': [5186], 'most': [5192], 'cases': [5193], 'suppression': [5194, 5232], 'enzymes': [5197], 'matches': [5204], 'response': [5206], 'intact': [5208, 5262], '(ERK1/2': [5210], 'AKT/PKB).': [5212], 'inactivated': [5222], 'dual': [5227], 'incoming': [5234], 'EGF-associated': [5235], 'stimulation': [5236], 'some': [5244], '(i.e.': [5246], 'p38)': [5247], 'system': [5255], 'point': [5266], 'complexity': [5269], 'regulation,': [5272], 'incorrect': [5277], 'inactivation': [5281, 5292], 'cascade': [5288], 'Papillomavirus': [5301], 'E6/E7': [5302], 'Oncoproteins—Human': [5303], 'etiological': [5308], 'Immortalization': [5316], 'step': [5326], 'process.': [5329], 'immortalization': [5331], 'oncoproteins,': [5338], 'E6,': [5339], 'reduces': [5341], '(54Martin': [5351], 'L.G.': [5352], 'Demers': [5353], 'G.W.': [5354], 'Galloway': [5355], 'D.A.': [5356], 'Virol.': [5358], '72:': [5360], '975-985Crossref': [5361], 'principle,': [5366], 'seem': [5369], 'possible': [5370], 'might': [5374], 'overcome': [5375], 'anti-survival': [5377], 'E7.': [5388], 'fact': [5391], 'inhibitor': [5397], 'despite': [5399], 'E6/E7-positive': [5401], 'background': [5402], 'therapeutic/preventive': [5410]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2029085730', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-14T07:40:36.174958', 'created_date': '2016-06-24'}
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