Title: Intracellularly injected inositol hexakisphosphate induces a biphasic current in identified neurons of Aplysia
Abstract: Inositol hexakisphosphate (IP6) was pressure-injected into the somata of the identified neurons (R9-R12) in the abdominal ganglion of Aplysia. Intracellular injection of IP6 into a neuron voltage-clamped at −45 mV reproducibly induced a biphasic membrane current consisting of an inward current (Ii(IP6)) followed by a slow outward current (Io(IP6)). Conductance is increased at the peaks of these currents. The extrapolated reversal potential of Ii(IP6) was −34 mV, whereas Io(IP6) was increased by depolarization and decreased by hyperpolarization up to −75 mV, where it disappeared. Ion substitution and pharmacological experiments suggest that microinjection of IP6 into the Aplysia neurons activates two or more separate types of ion channels.
Publication Year: 1989
Publication Date: 1989-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 10
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